1997

Study confirms that protease inhibitor cocktail can delay HIV disease progression and death. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: NIAID AIDS Agenda. 1997 Mar;:1-2. Unique Identifier : AIDSLINE AIDS/97702455; Randall P; A study funded by the National Institute of Allergy and Infectious Diseases (NIAID) has shown that combination protease inhibitor therapy plus two nucleoside analogues is significantly more effective than using two nucleoside analogs alone in reducing the occurrence of AIDS-defining illnesses and death. Since prelimin
Panel affirms importance of prenatal AZT use. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: NIAID AIDS Agenda. 1997 Mar;:3, 10. Unique Identifier : AIDSLINE AIDS/97702456; Bowersox J; ACTG 076 showed that AZT dramatically reduced the rate of mother-to-child transmission of HIV when administered during pregnancy and childbirth. Researchers concluded that the benefits far outweighed possible increased cancer risks, and emphasized the
NIAID researchers present new findings at retrovirus meeting. National Institute of Allergy and Infectious Diseases. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: NIAID AIDS Agenda. 1997 Mar;:4, 11. Unique Identifier : AIDSLINE AIDS/97702457; Doepel L; Folkers G; Research presented at the Third Conference on Retroviruses and Opportunistic Infections included reports on partial restoration of immune function and prolonged survival in people with HIV. Findings from several studies are highlighted. ACTG 315 suggests that potent new drug cocktails may partially restore immune syst
New vaccine advisory committee endorses innovative grant program. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: NIAID AIDS Agenda. 1997 Mar;:5. Unique Identifier : AIDSLINE AIDS/97702458; Bowersox J; A new grant program from the National Institute of Allergy and Infectious Diseases (NIAID), called the INNOVATION Grant Program for Approaches in HIV Vaccine Research, is designed to speed the pace of work on developing an AIDS vaccine. The first phase of this pilot program encourages three areas of research: understa
1996--a very good year for pathogenesis research. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: NIAID AIDS Agenda. 1997 Mar;:8-9. Unique Identifier : AIDSLINE AIDS/97702459; Bowersox J; 1996 was a watershed year for AIDS research, largely due to the introduction of protease inhibitors . Researchers also gained crucial new knowledge about the mechanism by which HIV infects CD4 cells, creating an opportunity for deciphering the disease process. Import
NIAID funds pediatric AIDS clinical trials group. National Institute of Allergy and Infectious Diseases. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: NIAID AIDS Agenda. 1997 Mar;:12. Unique Identifier : AIDSLINE AIDS/97702460; Doepel L; The National Institute of Allergy and Infectious Diseases (NIAID) has awarded 23 4-year grant programs to the Pediatric AIDS Clinical Trials Group, a national network that coordinates research projects. The money will support 21 trials, a data management center, and a new Coordinating and Operating Center. The restruc
Trends in HIV/AIDS among women of color. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: Update/Natl Minor COUNC. 1997 Mar;:1-4. Unique Identifier : AIDSLINE AIDS/97702461; Maldonado M; The incidence rates of HIV and AIDS among African American and Hispanic women is growing dramatically, and is now the third leading cause of death among women 25 to 44 years old. In developing countries, most women contract HIV from unprotected heterosexual sex; in the U.S., the majority of cases can be traced to inje
ACTG 076 and reduction of perinatal transmission. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: Update/Natl Minor COUNC. 1997 Mar;:4-7, 9. Unique Identifier : AIDSLINE AIDS/97702462; ACTG 076 findings demonstrated that a regimen of zidovudine (ZDV) reduced perinatal HIV transmission by two-thirds in infants whose mothers met specific eligibility criteria, including no previous antiretroviral treatment. The study is being hailed as one of the most significant breakthroughs in prevention of HIV, alt
The influence of hormones and HIV genital transmission in women. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: Update/Natl Minor COUNC. 1997 Mar;:9-11. Unique Identifier : AIDSLINE AIDS/97702463; An animal study with rhesus macaque monkeys showed that those who received subcutaneous progesterone implants were 7.7 times more likely to become infected with SIV. The findings raised strong concerns about two contraceptives on the market that contain progesterone, Depo-Provera and Norplant. The findings are not nec
The drugs we've got...the drugs we're getting...beyond blood. A three-part look at the Fourth Conference on Retroviruses and Opportunistic Infections. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: J Int Assoc Physicians AIDS Care. 1997 Apr;3(4):9-13, 16-8, 21-40. Unique Identifier : AIDSLINE AIDS/97702490; Mascolini M; Some of the most compelling presentations at the Fourth Conference on Retroviruses and Opportunistic Infections were those involving the presence of HIV outside of the blood stream. Other topics discussed included drug-versus-drug studies, antiretroviral therapy for children, and studies showing
Opportunistic infections: stemming the tide. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: J Int Assoc Physicians AIDS Care. 1997 Apr;3(4):42-7. Unique Identifier : AIDSLINE AIDS/97702491; MacDougall DS; Reports from the 1997 Fourth Conference on Retroviruses and Opportunistic Infections reveal encouraging responses to the latest antiretroviral regimens, including using protease inhibitors for treating opportunistic infections. Unfortunately, there appears to be les
A French lesson. French experience shows full funding of treatment advances saves money. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: J Int Assoc Physicians AIDS Care. 1997 Apr;3(4):49. Unique Identifier : AIDSLINE AIDS/97702492; Alcorn K; France s HIV treatment expenditures, the highest in Europe and second only to the United States , have created evidence of the real-life cost-effectiveness of triple combination antiretroviral therapy. The French have demonstrated that savings in treatment costs can be obtained with ear
Themes: the IVth Conference on Human Retroviruses and Opportunistic Infections. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: PI Perspect. 1997 Mar;(No 21):1-4. Unique Identifier : AIDSLINE AIDS/97702493; Presentations at the Fourth Conference on Human Retroviruses and Opportunistic Infections revealed a growing consensus on AIDS research and treatment. The most encouraging aspects of treatment included consistent reductions in viral load, viral load reductions resulting from first-line use of two or more highly active
Viral load and progression. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: PI Perspect. 1997 Mar;(No 21):6-7. Unique Identifier : AIDSLINE AIDS/97702494; Several studies are currently investigating the best ways to use new AIDS drug therapies and handle drug resistance. One study shows that HIV RNA levels in semen strongly correlate with RNA levels in plasma. Other studies report correlations in viral load changes in plasma and lymphoid tissue following combination dru
ACTG 320: last of the body count trials? Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: PI Perspect. 1997 Mar;(No 21):7. Unique Identifier : AIDSLINE AIDS/97702495; ACTG 320, to no one s surprise, was halted early when results clearly showed two-drug therapy was inferior to a three-drug regimen. Many thought the study was unnecessary because previous studies already concluded that triple combinations were more effective. So-called body count trials, as ACTG 320 was viewed, will n
Antiviral update. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: PI Perspect. 1997 Mar;(No 21):8-10. Unique Identifier : AIDSLINE AIDS/97702496; Reports from the 1997 Fourth Conference on Human Retroviruses and Opportunistic Infections continued to present the success of three-drug combinations for the treatment of HIV, and some studies indicate enough restoration of the immune system to sufficiently overcome some opportunistic infections. Updates are provided
AZT during pregnancy. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: PI Perspect. 1997 Mar;(No 21):10. Unique Identifier : AIDSLINE AIDS/97702497; A National Institutes of Health (NIH) independent panel determined that the benefits of HIV-infected pregnant women taking AZT outweigh any risks of AZT leading to cancer in the child. However, the need to counsel HIV-infected pregnant women on the be
Nelfinavir at six months. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: PI Perspect. 1997 Mar;(No 21):11-2. Unique Identifier : AIDSLINE AIDS/97702498; Nelfinavir, the newest protease inhibitor to be approved by the Food and Drug Administration ( FDA ), showed promising preliminary data when it was combined with AZT and
Pediatric update. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: PI Perspect. 1997 Mar;(No 21):12-3. Unique Identifier : AIDSLINE AIDS/97702499; Data is just beginning to emerge concerning protease inhibitor use in children. Studies still require children to take single drugs for long periods, despite the evidence from adult studies showing that prolonged use of these drugs is improper; many children have developed resistance to these drugs. Children, like adu
Glaxo 1592: a call for access, a call for caution. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: PI Perspect. 1997 Mar;(No 21):13-4. Unique Identifier : AIDSLINE AIDS/97702500; Glaxo Wellcome is initiating an expanded access program for its new nucleoside drug, GW1592. It is suggested that, due to Glaxo s problematic drug production, the company make the liquid pediatric formulation for use by adults, make parallel small-scale production lines, o
Protease inhibitors and beyond. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: PI Perspect. 1997 Mar;(No 21):15-6. Unique Identifier : AIDSLINE AIDS/97702501; A new generation of protease inhibitors is entering studies. Abbott Lab s ABT-378 and Pharmacia/Upjohn s PNU-140690 are beginning clinical studies and both are designed to overcome resistance problems. Several companies are developing new compounds to inhibit revers
HIV-related weight loss. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: PI Perspect. 1997 Mar;(No 21):16. Unique Identifier : AIDSLINE AIDS/97702502; Data from a recent study of the testosterone patch do not support its use for treating HIV-related weight loss. Testosterone as a therapy may require higher doses than the body normally produces. Currently, the only approved therapies are megestrol (Megace), dronabinol (Marinol), and recombinant human growth hormone (
IL-2 update. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: PI Perspect. 1997 Mar;(No 21):17. Unique Identifier : AIDSLINE AIDS/97702503; Interleukin-2 has long been researched for treating HIV and has shown the ability to initiate large increases in CD4+ cells in HIV-infected patients; people with more advanced disease have smaller responses. Side effects have been predictable and are sometimes severe. Data suggest the new cells function properly, howe
Medicaid: the system and how to use it. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: PI Perspect. 1997 Mar;(No 21):18-20. Unique Identifier : AIDSLINE AIDS/97702504; Medicaid is a lifeline to HIV care for roughly half of the adults living with AIDS and ninety percent of the children living with AIDS, but it harbors challenges for those who seek to use it. Applying for Medicaid, preparing for the application process, reducing bureaucratic delays, accessing quality care within the c
PHS draft guidelines recommend triple drugs as initial therapy. Public Health Service. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Alert. 1997 May;12(5):49-52. Unique Identifier : AIDSLINE AIDS/97702507; The first government-sanctioned HIV treatment guidelines are being finalized by the National Institutes of Health (NIH) Office of AIDS Research and the National Institute of Allergy and Infectious Diseases (NIAID). The guidelines will replace those developed by the Public Health Service in 1993, before any of the
Disability Act umbrella covers asymptomatic HIV. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Alert. 1997 May;12(5):52-4. Unique Identifier : AIDSLINE AIDS/97702508; A landmark discrimination case was won by an asymptomatic HIV-infected woman whose dentist refused to treat her in his office. He offered to treat her at a hospital, which would have involved much higher costs to her. The decision is controversial; some have criticized it as a civil rights victory that has subverted g
HIV Prevention Act would require HIV reporting. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Alert. 1997 May;12(5):54-5. Unique Identifier : AIDSLINE AIDS/97702509; The HIV Prevention Act of 1997 proposes mandatory, confidential reporting of HIV infection, mandatory partner notification, and a provision that would allow providers to refuse to perform invasive treatment to patients who refuse an HIV test. The bill has been endorsed by the America
Minorities miss out on AIDS survival increase. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Alert. 1997 May;12(5):55-7. Unique Identifier : AIDSLINE AIDS/97702510; AIDS and HIV infection rates are dropping dramatically among white Americans, but African Americans and Hispanics are not benefiting proportionately from treatment advances. Jocelyn Elders, the former U.S. Surgeon General, said that until these communities become more educated about the disease and its prevention, the
After long delays, Hopkins offers AIDS managed care. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Alert. 1997 May;12(5):57-9. Unique Identifier : AIDSLINE AIDS/97702511; Johns Hopkins University s AIDS program is about to offer a capitated rate structure for the State s Medicaid population. Some experts believe that putting Medicaid patients under managed care could be disastrous if rates are capitated. AIDS care, which has recently been seen as part of primary care, is moving back to
Fourth protease inhibitor hits the market. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Alert. 1997 May;12(5):59-60. Unique Identifier : AIDSLINE AIDS/97702512; Nelfinavir ( Viracept ) became the fourth protease inhibitor to gain marketing clearance from the Food and Drug Administration ( FDA ). Approved in mid-March, Viracept will make a contribution to the efforts to treat the
Know these facts about HIV in the `90s. National Minority AIDS Council. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Alert. 1997 May;12(5):suppl 1-2. Unique Identifier : AIDSLINE AIDS/97702513; Recent studies show that HIV is active in an infected person s body from the moment of infection, and it reproduces and spreads very rapidly. Disease mechanisms, viral load, and T-cell counts, are described in laymen s terms. Patients are cautioned about possible problems that will result from noncompliance with the p
Stay healthier longer by fighting infections. National Institutes of Health. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Alert. 1997 May;12(5):suppl 2. Unique Identifier : AIDSLINE AIDS/97702514; HIV infection leaves many patients vulnerable to serious opportunistic infections. Common infections are listed, as well as guidelines for maintaining health. Patients are advised to maintain a healthy lifestyle, obtain regular medical care, and begin prophylactic treatment if so advised by their health care provider.
Time limit applies even if patient is unaware of infection. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Apr 18;12(7):1, 9. Unique Identifier : AIDSLINE AIDS/97702515; No exception will be made for AIDS in Florida s strict four-year limit for filing medical malpractice claims arising from transfusions and contaminated blood. The State Supreme Court ruled that Francine Damiano, who contracted HIV from a blood transfusion in June 1986 but remained unaware of the contamination until Ap
President selects Thurman to oversee national AIDS policy. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Apr 18;12(7):1, 10. Unique Identifier : AIDSLINE AIDS/97702516; President Bill Clinton appointed Sandra L. Thurman as the nation s new AIDS policy director. This will be the Clinton administration s third such director in 45 months. Thurman was the executive director of AID Atlanta, and the director of advocacy programs at the Task Force for Child Survival and Development at the C
College aide may be liable for forcing out student with HIV. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Apr 18;12(7):2. Unique Identifier : AIDSLINE AIDS/97702517; An applicant to Louisiana s Cameron College alleges that the financial aid counselor obstructed her attempt to enter the medical assistant program because she is HIV-positive. Applicant Pansy Griffin claims that counselor Pam Corona insisted that all books and uniforms be paid for in advance, a requirement not imposed
Houston authorizes presentation of HIV videos in city jails. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Apr 18;12(7):2. Unique Identifier : AIDSLINE AIDS/97702518; The Houston City Council voted to begin showing HIV prevention videos in city jails. The city s Health and Human Services Department determined that inmates need the information but the plan was challenged by critics within the City Council and some citizens of the Houston area. A study found six percent of inmates in
Diner's claim of blood-tainted food is set for appeal. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Apr 18;12(7):3. Unique Identifier : AIDSLINE AIDS/97702519; Maureen Davis filed suit contending she ate most of a biscuit and gravy from a Hardee s restaurant before realizing it was contaminated with human blood. Davis claims she suffered mental anguish over the possibility of contracting HIV; tests show she is not infected. The Alabama Department of Forensic Science determin
U.S. Supreme Court refuses appeal on union seniority issue. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Apr 18;12(7):3. Unique Identifier : AIDSLINE AIDS/97702520; The U.S. Supreme Court refused to review an appeal made by a worker who was denied an accommodation for his disability because the union contract awarded jobs based on seniority. The 7th U.S. Circuit Court of Appeals ruling regarding the railroad employee with epilepsy who was warned against working from heights or at
Suit alleges Chicago schools denied job based on HIV. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Apr 18;12(7):4-5. Unique Identifier : AIDSLINE AIDS/97702521; In 1996, the Lambda Legal Defense and Education Fund persuaded the Chicago Board of Education to revoke a policy that demands applicants to disclose their HIV status. The Board promised to revise the policy, but on March 27, 1997 Lambda filed suit in U.S. District Court against the school board on behalf of an applica
Lack of access to records did not mar fairness of trial. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Apr 18;12(7):5. Unique Identifier : AIDSLINE AIDS/97702522; The estate of Timothy B. Baker will receive a $75,000 emotional distress award in addition to $104,109 in emotional damages from Dr. Woodruff J. English, II, an infectious disease specialist. Baker suffered an allergic reaction to Cotrim, a sulfa-based medicine prescribed by Dr. English. The reaction resulted in Baker
Police must pay $60,000 for revealing waiter's HIV status. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Apr 18;12(7):6-7. Unique Identifier : AIDSLINE AIDS/97702523; In Kokomo, IN, an out-of-court settlement of $60,000 was reached in an HIV privacy lawsuit. The case stemmed from a city police officer s demand that a restaurant assign him a new waiter because he did not want to be served by a full-blown AIDS-infested person. The waiter, known in the case as John Doe, lost his job
Court affirms conviction of HIV-positive prostitute. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Apr 18;12(7):7. Unique Identifier : AIDSLINE AIDS/97702524; The Indiana Court of Appeals ruled that a defendant who was involved in a melee with police can be found guilty of battery by body waste as well as resisting arrest. The appeals court determined that these two charges do not constitute double jeopardy. The case involves Constance Newman, an HIV-positive prostitute who
Tips for starting a peer education program for inmates. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Apr 18;12(7):8-9. Unique Identifier : AIDSLINE AIDS/97702525; Peer education programs have met with some success in changing HIV risk behaviors in the prison setting. Peer educators effectively communicate with other inmates about how the virus is spread and what can be done to reduce the risk of infection. Properly trained, peer educators may be more credible and relevant with
Center not liable for defamation from false-positive hepatitis test. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Policy Law. 1997 Apr 18;12(7):11. Unique Identifier : AIDSLINE AIDS/97702526; The Nebraska Court of Appeals ruled that Donald R. Helmstadter does not have a cause of action against the Lincoln Plasma Center in Lincoln, NE. The center blacklisted him as a carrier of hepatitis B virus; subsequent tests proved Helmstadter was uninfected. Helmstadter, a paid plasma donator, was placed on an ineligi
Fewer AIDS deaths and illnesses: new information. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Treat News. 1997 Feb 21;(No 265):1-3. Unique Identifier : AIDSLINE AIDS/97702527; James JS; AIDS death rates have fallen to about half of the previous levels among those who have access to new treatment options. Information on survival and hospitalization rates presented at the recent retroviruses conference is summarized. The 48 percent decline in New York City rates for AIDS deaths is attributed to more te
Nelfinavir - major trial results at retroviruses conference. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Treat News. 1997 Feb 21;(No 265):3-4. Unique Identifier : AIDSLINE AIDS/97702528; Nelfinavir ( Viracept ) is expected to be approved soon by the Food and Drug Administration ( FDA ). This fourth protease inhibitor appears to have fewer side effects, a different resistance profile, and offers new option
Danger: possibly fatal interactions between ritonavir and "ecstasy," some other psychoactive drugs. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Treat News. 1997 Feb 21;(No 265):5. Unique Identifier : AIDSLINE AIDS/97702529; Mirken B; Following the death of a British AIDS patient who was taking the protease inhibitor ritonavir when he died of an overdose of MDMA, or ecstasy, ritonavir producer Abbott Laboratories has acknowledged potentially da
Free viral load tests becoming available for uninsured patients. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Treat News. 1997 Feb 21;(No 265):5-6. Unique Identifier : AIDSLINE AIDS/97702530; Viral load test manufacturers have started two programs to make the tests available to those who cannot pay for them. To qualify, patients must be HIV-positive, have a doctor order the test, and not be able to have the costs covered through their insurance. Both PCR (polymerase chain reaction, by
ABT-378: Abbott "second generation" protease inhibitor. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Treat News. 1997 Feb 21;(No 265):6. Unique Identifier : AIDSLINE AIDS/97702531; James JS; Abbott Laboratories has released the first public data on ABT-378, a new generation protease inhibitor that is designed to be effective even against protease inhibitor-resistant HIV. ABT-378 is active against viruses that are resistant to
Drug-related neuropathy: low acetylcarnitine levels found. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Treat News. 1997 Feb 21;(No 265):6-7. Unique Identifier : AIDSLINE AIDS/97702532; James JS; Persons with peripheral neuropathy induced by ddI, ddC , or d4T were found to have low levels of acetylcarnitine in their blood. The
Stanford NAC study: glutathione level predicts survival. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Treat News. 1997 Mar 7;(No 266):1-5. Unique Identifier : AIDSLINE AIDS/97702533; James JS; CD4 cells with low levels of glutathione, a biochemical that protects cells from oxidative stress, have been found to be predictive of poor survival. A randomized study of N-acetyl-cysteine, a drug that helps replenish glutathione, began with in-depth analysis of glutathione levels in different lymphocyte subsets, and
AIDS survival: first drop in total deaths in U.S.; larger drop in France. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Treat News. 1997 Mar 7;(No 266):1, 6-7. Unique Identifier : AIDSLINE AIDS/97702534; James JS; In February 1997, the U.S. Centers for Disease Control and Prevention (CDC) reported a 12 percent decline in AIDS deaths over a 1-year period, the first drop in total deaths from AIDS in the United States . The decline was greatest in the West and Northeast, followed by the Midwest and
Protease inhibitors: major study stopped when 3-drug arm proves superior. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Treat News. 1997 Mar 7;(No 266):7-8. Unique Identifier : AIDSLINE AIDS/97702535; ACTG 320, a clinical trial comparing indinavir / AZT / 3TC to AZT/3TC was stopped early when it became clear that the 3
San Francisco: cattle grazing, reservoirs, and cryptosporidiosis. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Treat News. 1997 Mar 7;(No 266):8. Unique Identifier : AIDSLINE AIDS/97702536; Sabados R; The San Francisco Public Utilities Commission is considering no longer allowing cattle to graze in watershed areas. Since 40-60 percent of cattle in the area are infected with cryptosporidia, they are considered a source of the disease when their feces, containing the parasite, runs off into the water supply. A vote w
Nelfinavir (Viracept) approved: fourth protease inhibitor available. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Treat News. 1997 Mar 21;(No 267):1-2. Unique Identifier : AIDSLINE AIDS/97702537; James JS; The Food and Drug Administration ( FDA ) approved nelfinavir ( Viracept ) for both adult and pediatric use for treatment of HIV infection when antiretroviral therapy is warranted. The drug is the fourth protease inhibitor
It's time to approve more surrogate markers. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Treat News. 1997 Mar 21;(No 267):3-4. Unique Identifier : AIDSLINE AIDS/97702538; Scondras D; Advances in AIDS treatments have led to nationwide declines in AIDS-related deaths, but the development of new therapies must continue. Because accepted markers for improved immune function are lacking, the further development of new therapies is stalled. Neither of the markers that are currently accepted, CD4 T-cell
AIDS treatment activism: focus on service. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Treat News. 1997 Mar 21;(No 267):4-8. Unique Identifier : AIDSLINE AIDS/97702539; James JS; To coincide with the tenth anniversary of ACT UP, the effectiveness of the AIDS treatment movement is assessed. Activists have been instrumental in sensitizing the medical community to the needs of patients, pressuring drug companies to develop programs to make treatments financially accessible, and establishing stand
Delavirdine (Rescriptor) approved. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Treat News. 1997 Apr 18;(No 269):1-3. Unique Identifier : AIDSLINE AIDS/97702540; James JS; The Food and Drug Administration ( FDA ) approved delavirdine ( Rescriptor ) for HIV-1 treatment in March. Delavirdine becomes the second non-nucleoside
Nelfinavir combination therapy: ten-month report. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Treat News. 1997 Apr 18;(No 269):3. Unique Identifier : AIDSLINE AIDS/97702541; Results of studies of a triple combination of nelfinavir, AZT , and 3TC were reported at the Fourth Conference on Retroviruses and Opportunistic Infections and at the International Con
PMPA--first human results. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Treat News. 1997 Apr 18;(No 269):3, 6. Unique Identifier : AIDSLINE AIDS/97702542; James JS; Gilead Sciences new antiretroviral, PMPA, has shown exceptional activity in some animal tests. Results of the first human trial show viral load reductions of 1.1 log after one week, theoretically the most possible decline after one week of treatment. Animal trials with SIV have shown a two to three log viral reductio
Standard treatments for HIV, Spring 1997. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Treat News. 1997 Apr 18;(No 269):4-5. Unique Identifier : AIDSLINE AIDS/97702543; Smith D; Current treatment standards dictate combination anti-HIV therapy. A brief guide to antiretroviral drugs, including reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, and protease inhibitors that are approved by the Food and Drug Admin
Medical marijuana wins temporary restraining order. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: AIDS Treat News. 1997 Apr 18;(No 269):7. Unique Identifier : AIDSLINE AIDS/97702544; Tobias T; A Federal judge in San Francisco has issued a temporary restraining order barring Federal officials from prosecuting physicians who recommend marijuana for medicinal purposes. The restraining order is temporary, and a settlement conference is scheduled for April 17, 1997. In the meantime, physicians can discuss uses o
Psychoneuroimmunology: a basis for HIV treatment. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: Focus. 1997 Feb;12(3):1-4. Unique Identifier : AIDSLINE AIDS/97702545; Leiphart JM; Lesbian and Gay Men's Center of San Diego, Lesbian and Gay Men's; Community Center, San Diego, CA.; Psychoneuroimmunology (PNI), the study of the impact of psychological factors on immunological diseases, has been studied in relation to AIDS in a flurry of research over the past 10 years. PNI research has shown that some psychological states lead to AIDS progression, while others improve immunity and survival. Some
Clearinghouse: PNI and AIDS. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: Focus. 1997 Feb;12(3):4-5. Unique Identifier : AIDSLINE AIDS/97702546; A bibliography of materials on psychoneuroimmunology (PNI) and AIDS is provided. The names and addresses of leading PNI researchers in Los Angeles, Miami, San Diego, and Boston are listed.
The biological basis for psychoneuroimmunology. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: Focus. 1997 Feb;12(3):5-6. Unique Identifier : AIDSLINE AIDS/97702547; Cole SW; University of California Los Angeles, School of Medicine, Los; Angeles, CA.; The brain and the immune system are linked by two major physiologic systems: the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal system (HPA). The effect of these systems on the immune system is related to HIV disease and HIV-related care. The SNS and the HPA both play roles in normal body func
A STEP summary of the XIth International AIDS Conference. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: STEP Perspect. 1996 Summer;8(2):1-10. Unique Identifier : AIDSLINE AIDS/97702548; Schouten JT; Issues presented at the International AIDS Conference included basic science, treatments, and social service needs of people with HIV. Topics highlighted include global epidemiology issues, the impact of AIDS on women, viral dynamics, viral load and resistance, immunologic factors, therapy guidelines and approved medi
Nutrition power not an alternative. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: STEP Perspect. 1996 Summer;8(2):12-3. Unique Identifier : AIDSLINE AIDS/97702549; Jensen J; Health and Nutrition Awareness, Santa Monica, CA.; Some nutritional therapy is considered alternative or experimental, but basic good nutrition is essential to effectively combat HIV. The gastrointestinal tract is susceptible to a variety of opportunistic infections. Common medical problems of the gastrointestinal system are listed, and patients are advised to choose
Evaluating treatment options and health care providers: strategies for self-advocacy. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: STEP Perspect. 1996 Fall;8(3):1-4. Unique Identifier : AIDSLINE AIDS/97702550; Shouten J; Hubert J; Coppedge B; HIV treatment has become so effective that people are beginning to speak of eradicating the disease. However, patients need to become thoroughly informed about treatment options in order to ensure that they are getting the best care available. Patients generally do better if their physician is experienced in dealing w
Recent development in the treatment and prevention of disseminated Mycobacterium avium complex (MAC). Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: STEP Perspect. 1996 Fall;8(3):5-6. Unique Identifier : AIDSLINE AIDS/97702551; Schouten JT; Whittemore S; Disseminated Mycobacterium avium complex (DMAC) is the third most common opportunistic infection in people with AIDS, infecting up to 50 percent of them. Symptoms include high fever, weight loss, fatigue, diarrhea, poor appetite, night sweats, and anemia. Diagnosis is by blood culture. Results of two recent studies ar
New recommendations on health care worker exposure to HIV. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: STEP Perspect. 1996 Fall;8(3):8-10. Unique Identifier : AIDSLINE AIDS/97702552; Woodward J; University of Washington, Seattle, WA.; Health care workers who deal with HIV patients are trained and knowledgeable in universal precautions. However, they remain at risk of seroconversion from accidental exposure, and new treatment options are highlighted. Theories on viral dynamics and aggressive antiretroviral regimens suggest that health care workers r
Dietary consideration and protease inhibitors. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: STEP Perspect. 1996 Fall;8(3):11-4. Unique Identifier : AIDSLINE AIDS/97702553; Lichtenstein BS; Protease inhibitor therapy requires that the patient have adequate liver function in order to detoxify the substance before it reaches toxic levels in the bloodstream. Liver functioning is described, as well as the effects of several drugs. Ritonavir ,
ICAAC update. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: STEP Perspect. 1996 Fall;8(3):15-6. Unique Identifier : AIDSLINE AIDS/97702554; Coppedge B; Research topics presented at the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) are highlighted. Topics include the clinical benefits of 3TC (lamivudine), combination
Depression & HIV: assessment and treatment. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: STEP Perspect. 1997 Winter;9(1):1-5. Unique Identifier : AIDSLINE AIDS/97702555; Elliott A; University of Washington, Madison Clinic, Seattle, WA.; Although the advent of protease inhibitors has greatly extended the life expectancy of those living with HIV, they also have introduced the problems of emotionally dealing with a chronic illness. Depression appears to be the most common psychiatric disorder found am
Food, fitness and HIV: the connection. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: STEP Perspect. 1997 Winter;9(1):6, 8. Unique Identifier : AIDSLINE AIDS/97702556; Beesley S; Maurice J; Chicken Soup Brigade, Seattle, WA.; An HIV-positive diagnosis is often followed by wasting syndrome, in which chronic loss of muscle makes the patient feel progressively weaker and sicker. Exercise and eating can minimize muscle loss. Patients are advised to eat small frequent meals with high calorie and high protein foods. They should also eat at least
Immune modulation with IL-2 and IL-12. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: STEP Perspect. 1997 Winter;9(1):9-12. Unique Identifier : AIDSLINE AIDS/97702557; Boonprakong L; University of Washington, School of Medicine, AIDS Clinical; Trials Unit, Seattle, WA.; Scientists have identified a number of chemical messengers that play a fundamental role in directing the body s natural response to the invasion of organisms and pathogens in the human immune system. One group, cytokines, are an essential communications link between the cells of the immune system and the body. The dec
AIDS survival progress. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: STEP Perspect. 1997 Winter;9(1):15-6. Unique Identifier : AIDSLINE AIDS/97702558; Fowler K; Much of the good news in AIDS treatment is buried in medical literature that is technical and difficult to read. This overview of current research in progress describes the positive findings of several studies. One study shows that only 55 percent of those diagnosed in 1983 survived for a year, while 90 percent diagno
List of studies - Spring 1997. University of Washington AIDS Clinical Trials Unit. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: STEP Perspect. 1997 Winter;9(1):17-8. Unique Identifier : AIDSLINE AIDS/97702559; A chart listing current studies that are open for enrollment at the University of Washington in Spring 1997 is provided. The diseases being studied, the treatments involved, the length of the study, and a short description of each trial are given.
Opportunistic disease and other condition studies open for enrollment--August 1996. University of Washington AIDS Clinical Trials Unit. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: STEP Perspect. 1996 Summer;8(2):18-9. Unique Identifier : AIDSLINE AIDS/97702560; A chart listing the current studies that are open for enrollment at the University of Washington in August 1996 is provided. The diseases being studied, the treatments involved, the length of study, and a short description of each trial are given.
List of studies - October 1996. University of Washington AIDS Clinical Trials Unit. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: STEP Perspect. 1996 Fall;8(3):17-8. Unique Identifier : AIDSLINE AIDS/97702561; A chart listing current studies that are open for enrollment at the University of Washington in October 1996 is provided. The diseases being studied, the treatments involved, the length of study, and a short description of each trial are given.
Some relief from the epidemic. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: GMHC Treat Issues. 1997 Mar;11(3):1-3. Unique Identifier : AIDSLINE AIDS/97702562; Cadman JA; Death and hospitalization rates for people with AIDS dropped sharply in 1996, due to prevention of opportunistic infections, better medical care, and combination antiretroviral therapy. The Centers for Disease Control and Prevention (CDC) announced that this was the first decline since the epidemic was identified. Res
Spring cleaning in trial land. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: GMHC Treat Issues. 1997 Mar;11(3):4-7. Unique Identifier : AIDSLINE AIDS/97702563; Gilden D; Several clinical trials have been shut down earlier than planned, following the striking results shown in the trials. ACTG 320, studying whether an AZT / 3TC combination was more effect
A NAC for controversy. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: GMHC Treat Issues. 1997 Mar;11(3):7, 10-2. Unique Identifier : AIDSLINE AIDS/97702564; Gilden D; Cadman J; NAC (N-acetylcysteine) is a compound essential for the synthesis of glutathione, a cellular antioxidant. Administration of NAC is useful in prolonging survival, and people with HIV should avoid behaviors such as chronic use of alcohol or acetaminophen (Tylenol) that deplete glutathione. Glutathione is a key compound f
FDA approves nelfinavir. Food and Drug Administration. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: GMHC Treat Issues. 1997 Mar;11(3):8. Unique Identifier : AIDSLINE AIDS/97702565; The Food and Drug Administration ( FDA ) approved Agouron Pharmaceutical s new protease inhibitor, nelfinavir, in March. Nelfinavir received clearance for distribution through the agency s accelerated approval procedure, and is the first of its class
More pharmacies to carry Crixivan. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: GMHC Treat Issues. 1997 Mar;11(3):8-9. Unique Identifier : AIDSLINE AIDS/97702566; Access to indinavir ( Crixivan ) has been severely limited by production problems since it entered the market in March of 1996, and access has only been through the mail-order Stadtland
Viral load patient assistance programs. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: GMHC Treat Issues. 1997 Mar;11(3):9. Unique Identifier : AIDSLINE AIDS/97702567; Chiron and Roche have set up patient assistance programs to insure access to their viral load tests for patients who cannot pay for them. Roche s program involves sending an applicant s doctor a voucher for a free test, which is performed within two weeks at a participating lab. Eligible patients can receive a maximum
New ways to treat HIV. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: Treat Rev. 1996 Dec;(No 23):2-3. Unique Identifier : AIDSLINE AIDS/97702568; Recent scientific breakthroughs have completely changed the treatment of HIV. Reducing HIV levels seems to slow the progression of the disease and to give the immune system a chance to recover, and aggressive early treatment is the norm. Viral load testing is used to measure the effectiveness of treatment regimens, an
Combination treatment -- study results. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: Treat Rev. 1996 Dec;(No 23):4-11. Unique Identifier : AIDSLINE AIDS/97702569; Research studies show that combinations of anti-HIV drugs work considerably better than any of them given alone, and have even been shown to reduce the level of HIV in the blood to undetectable levels. This overview examines all the current pharmaceuticals on the market, in combinations frequently prescribed. Side eff
Zinc finger inhibitor for HIV. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: Treat Rev. 1996 Dec;(No 23):13. Unique Identifier : AIDSLINE AIDS/97702570; Zinc finger inhibitors are a class of anti-HIV drugs currently under development and entering clinical trials. The drugs block a part of HIV known as zinc fingers, which help assemble new viruses as they leave an infected cell. Blocking zinc fingers means that HIV makes copies of itself that do not work and cannot inf
Three drug combo halves AIDS deaths. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: Treat Rev. 1997 Apr;(No 24):2-4. Unique Identifier : AIDSLINE AIDS/97702571; Although a safety review board stopped ACTG 320 before its completion, the study showed that a three-drug combination could cut the mortality rate from AIDS in half. Study participants who were taking two nucleoside analog drugs were also given a protease inhibitor, and they developed half as many opportunistic infect
New drug approved to treat HIV. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: Treat Rev. 1997 Apr;(No 24):5. Unique Identifier : AIDSLINE AIDS/97702572; Nelfinavir ( Viracept ) was approved in March 1997 by the Food and Drug Administration ( FDA ) as the fourth commercially-available protease inhibitor. It, like the others, is most effective in combination with two nucleo
Saquinavir switch study stopped. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: Treat Rev. 1997 Apr;(No 24):6. Unique Identifier : AIDSLINE AIDS/97702573; ACTG 333 has been discontinued. Early test results showed that people who took the hard-gel version of saquinavir received no benefit from switching to a new saquinavir formulation, or to indinavir . This suggests that patients who take saquinavir as t
Hand and foot pain study. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: Treat Rev. 1997 Apr;(No 24):6. Unique Identifier : AIDSLINE AIDS/97702574; A new clinical trial is studying the drug nerve growth factor as a potential treatment for HIV-related neuropathy that results from HIV-induced damage to nerve endings. The nerve damage often causes pain in the feet and the hands. Nerve growth factor may be the first treatment to repair damage to nerves. Patients on c
Advanced AIDS treatment. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: Treat Rev. 1997 Apr;(No 24):7. Unique Identifier : AIDSLINE AIDS/97702575; A trial has been started to study granulocyte-macrophage colony-stimulating factor (GM-CSF) in people with AIDS. This drug may help people to produce additional infection-fighting white blood cells. Participants need to be on approved HIV drugs. The test will involve shots injected under the skin three times a week; h
Ecstasy and ritonavir. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: Treat Rev. 1997 Apr;(No 24):7. Unique Identifier : AIDSLINE AIDS/97702576; The combination of ritonavir and the illegal drug MDMA (street name ecstasy) may be fatal. People taking both drugs had a two to three fold increase in ecstasy levels in the blood. There may be similar problems with patients on methadone.
[New drugs, new obstacles in the fight against HIV] Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: Sidahora. 1996 Aug/Sep;:13-4. Unique Identifier : AIDSLINE AIDS/97702577; Fonseca MS; Panos Institute, Washington, DC. panos@cais.com.; Treatment with protease inhibitors , drugs that inhibit HIV protease, an essential enzyme for the survival of the HIV virus, decreases HIV to undetectable levels and has generated great optimism. Although far from finding a cure, these findings are steps toward under
[Surviving AIDS in prison: autonomy and self-empowerment] Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: Sidahora. 1996 Aug/Sep;:15-6. Unique Identifier : AIDSLINE AIDS/97702578; Vasquez D; Gomez E; Living with HIV in prison is not a pleasant experience, especially without the tools to survive. It is public knowledge that the Correctional Department is indifferent toward inmates with AIDS. Educational information for prisoners living with HIV to learn as much as possible about AIDS and their rights is provided. M
[Awilda Gonzalez, working in AIDS inside and outside of prison] Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: Sidahora. 1996 Aug/Sep;:17-8. Unique Identifier : AIDSLINE AIDS/97702579; Awilda Gonzalez discusses her experiences working with incarcerated people living with AIDS. Awilda has worked as a counselor for Housing Works, an organization that provides housing and other services for people with AIDS. Awilda also worked at the Bedford Hills correctional facility. As an inmate, she helped to star
[ABC of the antivirals] Project Inform. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: Sidahora. 1996 Aug/Sep;:19-32. Unique Identifier : AIDSLINE AIDS/97702580; Scientists have tried to inhibit or slow down the HIV virus ever since the virus was identified as the cause of AIDS. Although the efforts have not produced a long-term solution, significant progress has been made. There is a correlation between the increase in HIV levels and the advanced state of the disease. Antivir
[What is the correct way to use protease inhibitors?] Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: Sidahora. 1996 Aug/Sep;:33-5. Unique Identifier : AIDSLINE AIDS/97702581; Agosto M; National Minority AIDS Council, Washington, DC.; Anyone infected with the HIV virus who is considering treatment should have as much information as possible about the different options available. To treat the infection, doctors are using antiretrovirals to slow down the production of the virus inside the body. Some of the issues that have to be addressed include ava
[Anal cancer] Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: Sidahora. 1996 Aug/Sep;:36-7. Unique Identifier : AIDSLINE AIDS/97702582; Majchrowicz M; Gomez E; AIDS Project Los Angeles, Los Angeles, CA.; Kaposi s sarcoma and cervical cancer are the most common AIDS-related cancers. Anal cancer, affecting both men and women, has largely been ignored. Since many diseases can occur around the anal area, there are not definitive symptoms to diagnose any abnormal growths. Studies have shown that people living with HIV suff
[Bilingual education program on HIV/AIDS treatment] Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: Sidahora. 1996 Aug/Sep;:38. Unique Identifier : AIDSLINE AIDS/97702583; Latino Commission on AIDS, New York, NY.; The Bilingual Education Program on HIV/AIDS Treatment educates individuals who live, work, and are affected by HIV/AIDS to develop their abilities as leaders and promoters of information on the treatment of HIV/AIDS. The program includes an overview of HIV/AIDS, treatments, and ways to access information and programs.
[Fraud and opportunism in Honduras] Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714. A fee will apply.: Sidahora. 1996 Aug/Sep;:39-40. Unique Identifier : AIDSLINE AIDS/97702584; Santana C; Catherine Quinn, a nurse from Chicago, works with people living with AIDS in Honduras . Catherine discusses the people who take advantage of the sick and poor for economic reasons. She recalls how people in Honduras were taken advant
An autocrine growth mechanism in retroperitoneal fibromatosis, a model for AIDS related Kaposi's sarcoma.: Diss Abstr Int [B]; 56(8):4107 1995. Unique Identifier : AIDSLINE ICDB/97619959; Woon M; Saint Louis Univ.; The human acquired immune deficiency syndrome (AIDS) is a global epidemic disease first recognized in 1981. Affected individuals develop severe impairment of both cellular and humoral immune functions with a variety of opportunistic infections and are susceptible to neoplastic developments such as Kaposi s sarcoma (KS
Escape from transforming growth factor-beta-mediated growth regulation in Epstein-Barr virus-positive or AIDS-associated transformed B cells.: Diss Abstr Int [B]; 56(8):4225 1995. Unique Identifier : AIDSLINE ICDB/97619996; Arvanitakis L; Brown Univ.; Transforming growth factor-beta (TGF-beta) is a member of a family of multifunctional growth factors regulating cell proliferation and differentiation. Generally, TGF-beta inhibits proliferation and has been shown to be an important regulator of immune responses. Here we show that TGF-beta1 induces growth arrest, but
Evaluation of lithium gamma-linolenate (EF-13), a novel antiviral and anti-neoplastic compound (Meeting abstract).: Can J Infect; 6(Suppl C):298C 1995. Unique Identifier : AIDSLINE ICDB/97624598; Conway B; Mpanju O; Randall S; Winther M; Univ. of British Columbia, Vancouver, British Columbia, Canada; Conventional approaches to antiviral therapy are based on the development of compounds that inhibit viral replication directly. EF-13, the lithium salt of the polyunsaturated fatty acid gamma linolenic acid (GLA), appears to have an indirect action against viral replication. GLA is reported to have differential cytoto
Interaction of the MAIDS defective virus with its host (Meeting abstract).: Leukemia and Lymphoma, Pathogenesis and Treatment, Molecular Aspects, p. 28. 18th Symposium of the International Association for Competitive Research on Leukemia and Related Diseases, Kyoto, Japan, October 29-November 3, 1995.. Unique Identifier : AIDSLINE ICDB/97625254; Jolicoeur P; Clinical Research Institute of Montreal, Montreal, H2W 1R7,; Canada; The murine AIDS (MAIDS) is a severe immune disease induced by a defective murine leukemia virus which codes for a single gene product, Pr60gag. Mutational analysis has revealed th Pr60gag is necessary and sufficient to induce disease and that is must be myristylated at its N-terminus. Peripheral mature B cells are the
Models of HTLV-I-induced diseases: infectious transmission of HTLV-I in inbred rats and HTLV-I env-pX transgenic rats (Meeting abstract).: Leukemia and Lymphoma, Pathogenesis and Treatment, Molecular Aspects, p. 32. 18th Symposium of the International Association for Competitive Research on Leukemia and Related Diseases, Kyoto, Japan, October 29-November 3, 1995.. Unique Identifier : AIDSLINE ICDB/97625260; Yoshiki T; Department of Pathology, Hokkaido Univ. Sch. Med., Sapporo 060,; Japan; To examine the pathogenic roles of HTLV-I in HTLV-I-induced diseases, we developed two models: namely HTLV-I carrier rats and HTLV-I env-pX transgenic rats. Among life long HTLV-I carriers in seven rat strains, only WKAH rats with the RT1k haplotype developed chronic progressive myeloneuropathy, resembling HAM/TSP cli
Immunotherapy with tumor vaccines in renal cancer (Meeting abstract).: Ann Oncol; 7(Suppl 1):18 1996. Unique Identifier : AIDSLINE ICDB/97625860; Pardoll DM; John Hopkins University School of Medicine, Baltimore, MD; There is mounting evidence that many if not all tumors possess antigens capable of being recognized by T cells. Over the past few years, our group has been analyzing the immune response induced by immunization with tumors engineered to secrete cytokines locally. In a study comparing multiple different cytokine genes,
Seminars in medicine of the Beth Israel Hospital, Boston. Pathogenesis of diseases induced by human lymphotropic virus type I infection: N Engl J Med; 328(16):1173-82 1993. Unique Identifier : AIDSLINE ICDB/97627321; Hollsberg P; Hafler DA; Department of Medicine, Brigham and Women's Hospital, Boston, MA; Human lymphotropic virus type I (HTLV-I), which has been associated with human disease only since the early 1980s, is a typical retrovirus with gag, pol, and env regions in its gene, but also has a unique pX region at the 3 end. Its epidemiology came under intensive study when tropical spastic paraparesis, T-cell leu
Management of fever in patients with cancer and treatment-induced neutropenia: N Engl J Med; 328(18):1323-32 1993. Unique Identifier : AIDSLINE ICDB/97627338; Pizzo PA; Pediatric Branch, National Cancer Institute, Bethesda, MD 20892; It is more than 30 years since the major role of neutropenia in the risk serious infections in cancer patients receiving chemotherapy was first recognized; such risks extend to other immunosuppressed patients such as those with AIDS or undergoing transplantation. Successful management of fever and neutropenia has dras
HIV risk among low-income African American mothers of elementary school children.: J Health Soc Policy. 1997;8(3):27-39. Unique Identifier : AIDSLINE AHA/97278789; Cummings GL; Battle R; Barker J; Krasnovsky F; Department of Epidemiology and Biostatistics, University of; California, San Francisco, USA.; Data from 119 African American low-income mothers of school aged children in Oakland, California show that 38% engaged in behavior that might place them at risk of exposure to the human immunodeficiency virus (HIV). Risk behaviors that were investigated included having multiple partners and having a partner with an in
Correlates of child care providers' interpretation of pediatric AIDS: implications for education and training.: Health Educ Res. 1997 Mar;12(1):53-60. Unique Identifier : AIDSLINE HTA/97267373; Coleman M; University of Georgia, Athens 30602, USA.; A total of 212 child care providers residing in a southeastern state were surveyed about their knowledge and attitudes toward AIDS and child care policies. Providers feeling about caring for an HIV-infected child, rather than their perceived knowledge of AIDS, were most consistently correlated with their factual know
Practice brief. Issue: Managing health information relating to infection with the human immunodeficiency virus (HIV). American Health Information Management Association.: J AHIMA. 1997 Feb;68(2):1 p. following 44. Unique Identifier : AIDSLINE AHA/97299566
Where all care is home care: HIV/AIDS in Thailand.: Caring. 1997 Apr;16(4):42-5. Unique Identifier : AIDSLINE AHA/97305739; Sacks RG; Population and Community Development Association, Bangkok,; Thailand.; In Thailand the concept of professional home care services does not exist in either the language or the culture. Virtually all health care, including care of people with HIV/AIDS, is provided by family caregivers in the home.
Bringing calm to the storm.: Mich Health Hosp. 1997 May-Jun;33(3):39. Unique Identifier : AIDSLINE AHA/97320332; Majors MC
OSHA issues hepatitis B disinfectant policy.: Exec Housekeep Today. 1997 May;18(5):9-10. Unique Identifier : AIDSLINE AHA/97294270; Goodman G; Marketing Counselors International, Inc., Santa Fe, NM 87504,; USA.
Une mort africaine : le sida au quotidien.: Paris : Editions du seuil, c1995 230 p. : ill (L'histoire immediate) Unique Identifier : AIDSLINE CAT/9703402; Prolongeau H
La prigione malata : letture in tema di AIDS, carcere e salute.: Torino : L'Harmattan Italia, c1996 232 p (Diritto, devianza e societa) Unique Identifier : AIDSLINE CAT/9702399; Magliona B
AIDS-SprechStunde : ein medizinisch-therapeutischer Ratgeber.: Stuttgart : Urachhaus, c1996 336 p. : ill (SprechStunde) Unique Identifier : AIDSLINE CAT/9701919; Straube M
Des infirmieres face au SIDA : representations et conduites, permanence et changements.: Paris : Editions INSERM, c1994 265 p (Analyses et prospective) Unique Identifier : AIDSLINE CAT/9502648; Giami A
Psycho-social and cultural aspects of AIDS.: Bern : Swiss National Foundation for Scientific Research, 1994 48 p Unique Identifier : AIDSLINE CAT/9705241; Hausser D
Sida et infection par le VIH. 3. ed. rev. et augm.: Paris : Masson, c1996 xiv, 288 p. : ill (Abreges) Unique Identifier : AIDSLINE CAT/9703228; Cassuto J
Virus Load und AIDS : Bedeutung der Virusbelastung fur die Therapie der HIV-Erkrankung.: Stuttgart ; New York : Georg Thieme Verlag, 1997 ix, 165 p. : ill (HIV-Medizin. Standards of Care) Unique Identifier : AIDSLINE CAT/9702695; Jager H
AIDS in U.S. hospitals, 1986-1987 : a national perspective.: Rockville, Md. : U.S. Dept. of Health and Human Services, Public Health Service, Agency for Health Care Policy and Research, Center for General Health Services Intramural Research, [1991] 21 p. : ill (Research note / Hopsital Studies Program ; 15) Unique Identifier : AIDSLINE CAT/9708705; Ball JK; Ball JK; Turner BJ
State of Maine comprehensive HIV prevention plan. Rev. Sept. 1996.: Augusta, Maine (11 Parkwood Dr., Augusta 04330) : The Group, 1996 1 v. (various pagings) : ill Unique Identifier : AIDSLINE CAT/9707916; Mercadante DP; Patterson S; Joy JE
The white death.: Sydney, NSW : Angus & Robertson ; New York, NY : HarperCollins, c1996 266 p. : ill., ports Unique Identifier : AIDSLINE CAT/9705272; Cribb J
HIV and community mental healthcare.: Baltimore : Johns Hopkins University Press, c1998 Unique Identifier : AIDSLINE CAT/9709831; Knox MD; Sparks CH
Practicing desire : homosexual sex in the era of AIDS.: Stanford, Calif. : Stanford University Press, 1996 viii, 322 p Unique Identifier : AIDSLINE CAT/9704932; Dowsett GW
The source : news and information from the Texas Department of Health, Bureau of HIV and STD Prevention. -spring 1995.: Austin, TX : The Bureau, v Unique Identifier : AIDSLINE CAT/9700563
AIDS and the law. 3rd ed.: New York : Wiley, 1997 xxxvi, 624 p Unique Identifier : AIDSLINE CAT/9708519; Webber DW
AIDS in Africa and the Caribbean,.: Boulder, Colo. : Westview Press, 1997 xv, 234 p Unique Identifier : AIDSLINE CAT/9708249; Bond GC
HIV kansensho no shinryo : iryo kankeisha no tebiki.: Tokyo : Kokumin Kenko Hoken Chuokai, hatsubai, Shakai Hoken Shuppansha, 1993 159 p. : ill Unique Identifier : AIDSLINE CAT/9512484; Kitamura T
HIV/AIDS and sexually transmitted diseases : WHO policy and strategic orientations.: Geneva : World Health Organization, [1996] 1 v. (various pagings) Unique Identifier : AIDSLINE CAT/9703798
HIV/AIDS fact finder.: Denver : National Conference of State Legislatures, c1993 v, 101 p Unique Identifier : AIDSLINE CAT/9704076
Immunopathogenesis of HIV infection.: Berlin ; New York : Springer, 1997 (Springer seminars in immunopathology ; v. 18, no. 3) Unique Identifier : AIDSLINE CAT/9710141; Fauci AS; Pantaleo G
Mortality due to HIV infection in Hawai'i 1984-1993.: Honolulu, Hawaii : Office of Health Status Monitoring, [1996] 24 p. : ill (R & S report ; issue no. 64) Unique Identifier : AIDSLINE CAT/9707782; Kong VL
On the continuum of HIV/AIDS care : nursing research and practice initiatives.: Geneva : International Council of Nurses, c1995 iv, 142 p Unique Identifier : AIDSLINE CAT/9707958; Schorr TM
Texas HIV/STD update : the quarterly bulletin of the Texas Department of Health, Bureau of HIV & STD Prevention. Vol. 1, no. 1 (summer 1995)-: Austin, Tex. : The Dept., [1995- v Unique Identifier : AIDSLINE CAT/9617138
Management of diarrheal disorders in the HIV+ patient. [videorecording]: Charleston, S.C. : Health Communications Network, Medical University of South Carolina, c1992 1 videocassette (1 hr., 19 min., 57 sec.) : sd., col. ; 1/2 in Unique Identifier : AIDSLINE AV/9616023; Belitsos P
Living sober II. [videorecording]: [Wilmette, Ill.] : G.T. Rogers, c1997 6 videocassettes (125 min., 40 sec.) : sd., col. ; 1/2 in. + 1 manual (i, 44 p.) + 1 workbook (i, 27 p.) Unique Identifier : AIDSLINE AV/9706021; Daley DC; (Producer) Examines the importance of coping successfully with the many problems that confront individuals in early recovery. Stresses the importance of both abstinence from all chemicals and change, both intrapersonal and interpersonal.
[Histopathologic features of cytomegalovirus lymphadenitis in the "immunocompetent" patient. Report of 7 cases]: Ann Pathol. 1996 Sep;16(4):254-60. Unique Identifier : AIDSLINE MED/97182356; Joubert M; Morin C; Moreau A; Heymann MF; Laboisse C; Gaillard F; Laboratoire d'Anatomie Pathologique A, CHRU-Hotel-Dieu, Nantes.; The authors report seven cases of cytomegalovirus lymphadenitis in apparently immunocompetent patients. One patient presented with an infectious mononucleosis-like illness. The main presentation of the others was isolated cervical lymphadenopathies. The lymph node pathology showed
[Role of guided fine needle punction in the diagnosis of deep-seated Aids-related infections. Report of a case of hepato-nodal histoplasmosis]: Ann Pathol. 1996 Sep;16(4):266-70. Unique Identifier : AIDSLINE MED/97182358; Longchampt E; Fabre M; Service d'Anatomie et de Cytologie Pathologiques, Hopital; Bicetre, Le Kremlia Bicetre.; A case of disseminated histoplasmosis diagnosed by fine needle aspiration biopsy is reported. The patient suffering from acquired immune deficiency syndrome (AIDS) had enlarged liver, spleen and mesenteric lymph nodes. Cytological smears prepared from a CT scan guided fine needle aspiration biopsy of one of the lymph
FIV infection of the domestic cat: an animal model for AIDS.: Immunol Today. 1997 Apr;18(4):182-9. Unique Identifier : AIDSLINE MED/97282208; Willett BJ; Flynn JN; Hosie MJ; Dept of Veterinary Pathology, University of Glasgow Veterinary; School, UK. b.willett@vet.gla.ac.uk
Immunopathology of onchocerciasis: a role for eosinophils in onchocercal dermatitis and keratitis.: Chem Immunol. 1997;66:26-40. Unique Identifier : AIDSLINE MED/97256964; Pearlman E; Division of Geographic Medicine, CWRU School of Medicine,; Cleveland, Ohio, USA.; This review has sought to demonstrate that eosinophils have an important role in the immunopathology of onchocercal dermatitis and keratitis. The most compelling evidence is the consistent presence of eosinophils and eosinophil granule proteins at the site of tissue damage, either after parasite death or direct inject
Solution structure of the HIV protease inhibitor acetyl-pepstatin as determined by NMR and molecular modeling.: J Biomol Struct Dyn. 1997 Feb;14(4):421-8. Unique Identifier : AIDSLINE MED/97227320; van Boulanger Y; Senecal L; Sauve G; INRS-Sante, Universite du Quebec, Pointe-Claire, Quebec,; Canada. Yvan_Boulanger@INRS-Sante.UQuebec, CA; The structure of acetyl-pepstatin has been investigated in solution by two-dimensional NMR spectroscopy and molecular modeling. The analysis of DQFCOSY, TOCSY and NOESY spectra lead to a full assignment of the -NMR signals both in DMSO-d6 and in TFE-d3:H2O 1:1. Interproton distances, dihedral angles and exchanger regi
Breast cancer and HIV infection: two case reports [letter]: Eur J Cancer. 1997 Mar;33(3):507-8. Unique Identifier : AIDSLINE MED/97300521; Cuvier C; Espie M; Extra JM; Marty M
Measurement of condom use self-efficacy and outcome expectancies in a geographically diverse group of STD patients.: AIDS Educ Prev. 1997 Feb;9(1):1-13. Unique Identifier : AIDSLINE MED/97237109; DiIorio C; Maibach E; O'Leary A; Sanderson CA; Celentano D; Emory University Rollins School of Public Health, Atlanta, GA; 30322, USA.; The aim of this project was to conduct an initial evaluation among sexually transmitted disease (STD) patients of the psychometric properties of two instruments: the National Institute of Mental Health (NIMH) multisite condom use self-efficacy scale and the NIMH multisite condom use outcome expectancy scale. The condo
Attitudes about AIDS education and condom availability among parents of high school students in New York City: a focus group approach.: AIDS Educ Prev. 1997 Feb;9(1):14-30. Unique Identifier : AIDSLINE MED/97237110; Rafferty Y; Radosh A; Academy for Educational Development, New York, NY 10011, USA.; This paper describes parents views of the New York City Public High School s AIDS Education and Condom Availability Program. It presents findings from 12 focus groups with 81 parents of students at six representative high schools. Focus groups were conducted as part of an independent, comprehensive 3-year evaluation
Understanding the intention of gay and bisexual men to take the HIV antibody test.: AIDS Educ Prev. 1997 Feb;9(1):31-41. Unique Identifier : AIDSLINE MED/97237111; Godin G; Myers T; Lambert J; Calzavara L; Locker D; Ecole des sciences infirmieres, Universite Laval. Quebec,; Canada.; This study offers an explanation for the intention of 1,512 gay and bisexual men to be tested for the HIV antibody. Participants were recruited through 125 gay-identified venues (bars, bathhouses, community dances) across Canada . Self-administered questionnaires assessed respondent
Communication of HIV serostatus between potential sex partners in personal ads.: AIDS Educ Prev. 1997 Feb;9(1):42-8. Unique Identifier : AIDSLINE MED/97237112; Hamers FF; Bueller HA; Peterman TA; Epidemic Intelligence Service, National Center for Prevention; Services, Centers for Disease Control and Prevention, Atlanta, GA; 30333, USA.; We studied reference to HIV in personal ads from 1986 to 1993 to assess knowledge of HIV serostatus as a criterion for selecting sex partners. Personals increased exponentially during 1986 to 1993. Men seeking men (MSM) were more likely (8%) to mention HIV than persons seeking other situations (0% to 1.6%). The propor
Toward reducing the spread of HIV in northeastern Thai villages: evaluation of a village-based intervention.: AIDS Educ Prev. 1997 Feb;9(1):49-69. Unique Identifier : AIDSLINE MED/97237113; Elkins D; Maticka-Tyndale E; Kuyyakanond T; Miller P; Haswell-Elkins M; Queensland Institute of Medical Research, Ontario, Canada.; This paper presents results of the evaluation of an intervention designed for northeastern Thai villages and particularly for village women. The intervention was based on established principles of behavior change, social learning theory, and community health promotion, and it was grounded in elicitation research. A to
An evaluation of teaching methods utilized during an HIV miniresidency course for Thai physicians.: AIDS Educ Prev. 1997 Feb;9(1):70-82. Unique Identifier : AIDSLINE MED/97237114; Zell SC; Department of Internal Medicine, University of Nevada School of; Medicine, USA.; This study examines the efficacy of medical education methods in improving the knowledge base and clinical skills of participants attending a 2-day miniresidency course in HIV infection. Instructional methods included: a didactic lecture format, diagnostic algorithm presentation, color slide photographic demonstration
Migrant laborers and AIDS in the United States: a review of the literature.: AIDS Educ Prev. 1997 Feb;9(1):83-93. Unique Identifier : AIDSLINE MED/97237115; Organista KC; Organista PB; School of Social Welfare, University of California at Berkeley; 94720, USA.; This article reviews the literature on the threat of AIDS to migrant laborers and seasonal farmworkers in the United States . The review includes a sociodemographic profile of migrants in the United States, estimations of HIV prevalence, and a summary of AIDS- and condom-related knowled
A pre-intervention survey to determine understanding of HIV and AIDS in farm worker communities in Zimbabwe.: AIDS Educ Prev. 1997 Feb;9(1):94-110. Unique Identifier : AIDSLINE MED/97237116; Laver SM; van den Borne B; Kok G; Woelk G; Department of Community Medicine, Medical School, University of; Zimbabwe, Harare, Zimbabwe.; A cumulative total of 41,298 AIDS cases have been reported in Zimbabwe as of March 1995. Of concern is the growing evidence of high levels of seroprevalence among rural farm workers. A pre-intervention survey was conducted by interview in one district to examine behavioral factor
Molecular typing of Cryptococcus neoformans: taxonomic and epidemiological aspects.: Int J Syst Bacteriol. 1997 Apr;47(2):432-42. Unique Identifier : AIDSLINE MED/97256929; Boekhout T; van Belkum A; Leenders AC; Verbrugh HA; Mukamurangwa P; Swinne D; Scheffers WA; Yeast Division, Centraalbureau voor Schimmelcultures, Delft, The; Netherlands. T.Boekhout@STM.TuDelft.nl; Pulsed-field gel electrophoresis (PFGE), randomly amplified polymorphic DNA (RAPD) analysis, serotype, and killer toxin sensitivity patterns of a wide range of saprobic, clinical, and veterinary isolates of both varieties of Cryptococcus neoformans were examined. C. neoformans var. neoformans and C. neoformans var. ga
Kikuchi disease (histiocytic necrotizing lymphadenitis) in association with HTLV1.: Br J Dermatol. 1997 Apr;136(4):610-2. Unique Identifier : AIDSLINE MED/97300950; Bataille V; Harland CC; Behrens J; Cook MG; Holden CA; Dermatology Department, St. Helier Hospital, Carshalton, Surrey,; U.K.; We report a 25-year-old male with fever, generalized lymphadenopathy and an erythematosus maculo-papular eruption affecting face and upper body. A diagnosis of Kikuchi disease (necrotizing histiocytic lymphadenitis) was made on lymph node histology. The patient was found to be positive for the human T-cell leukaemia l
Isolated subcutaneous candidal abscess and HIV disease [letter]: Br J Dermatol. 1997 Apr;136(4):647-9. Unique Identifier : AIDSLINE MED/97300970; Manfredi R; Mazzoni A; Nanetti A; Mastroianni A; Coronado OV; Chiodo F
Linoleic and alpha-linolenic acids differently modify the effects of elaidic acid on polyunsaturated fatty acid metabolism and some immune indices in rats.: Br J Nutr. 1997 Apr;77(4):645-56. Unique Identifier : AIDSLINE MED/97300490; Koga T; Nonaka M; Gu JY; Sugano M; Department of Food and Nutrition, Nakamura Gauen College,; Fukuoka, Japan.; To explore whether the metabolic responses to trans, compared with cis, fatty acids depend on the source of dietary polyunsaturated fatty acids (PUFA), male Sprague-Dawley rats, 5 weeks old, were fed on diets containing 30 g oleic (cis) or elaidic (trans) acids/kg in combination with either 70 g perilla oil (alpha-lin
Identification of a loop outside the active site cavity of the human immunodeficiency virus proteases which confers inhibitor specificity.: Biochemistry. 1997 Apr 29;36(17):5128-33. Unique Identifier : AIDSLINE MED/97282564; Towler EM; Thompson SK; Tomaszek T; Debouck C; Department of Molecular Genetics, SmithKline Beecham; Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA.; We have investigated the inhibitor specificity for the proteases of the human immunodeficiency viruses, types 1 and 2. Using a series of related inhibitors, the P1 side chain was confirmed to play a significant role in determining both the absolute and relative affinity for the enzymes. To further define the residues
A leucine zipper-like sequence from the cytoplasmic tail of the HIV-1 envelope glycoprotein binds and perturbs lipid bilayers.: Biochemistry. 1997 Apr 29;36(17):5157-69. Unique Identifier : AIDSLINE MED/97282568; Kliger Y; Shai Y; Department of Membrane Research and Biophysics, Weizmann; Institute of Science, Rehovot, Israel.; HIV-1 transmembrane envelope glycoprotein (gp41) has an unusually long cytoplasmic domain that has secondary associations with the inner leaflet of the membrane. Two highly amphiphatic alpha-helices in the cytoplasmic domain of gp41 have previously been shown to interact with lipid bilayers. We have detected a highly
Cytotoxicity of graft-derived lymphocytes: specific for donor heart endothelial cells?: J Heart Lung Transplant. 1997 Feb;16(2):209-15. Unique Identifier : AIDSLINE MED/97213167; Jutte NH; Knoop CJ; Heijse P; Balk AH; Mochtar B; Claas FH; Weimar W; Department of Internal Medicine I, University Hospital; Rotterdam/Dijkzigt, Erasmus University Rotterdam, The; Netherlands.; BACKGROUND: Previously, we showed that lymphocytes cultured from cardiac allografts can lyse lymphoid cell lines from donor origin. Because endothelial cell form the first allogeneic barrier to be encountered in vivo, the reactivity of graft-infiltrating cells against donor heart-derived endothelial cells (DoHEC) may
Cytokine messenger RNA expression by donor-specific cytotoxic T-cell clones after allogeneic heart transplantation.: J Heart Lung Transplant. 1997 Feb;16(2):216-21. Unique Identifier : AIDSLINE MED/97213168; Van Hoffen E; Gmelig-Meyling FH; Bosboom-Kalsbeek KC; Hu H; De Jonge N; Tilanus MG; Lahpor JR; De Weger RA; Department of Pathology, University Hospital, Utrecht, The; Netherlands.; BACKGROUND: After heart transplantation, expression of various cytokines can be detected in endomyocardial biopsy specimens both in the presence and in the absence of rejection. In this study we have analyzed the contribution of donor-specific CD8+ cytotoxic T cells to intragraft cytokine expression. METHODS: T cells
[AIDS-associated illnesses in radiologic diagnosis: overview and differential diagnosis]: Aktuelle Radiol. 1997 Mar;7(2):69-73. Unique Identifier : AIDSLINE MED/97261417; Rademaker J; Frahm C; Department of Medicine, Beth Israel Medical Center, New York,; USA.
Living with HIV and AIDS. Vancouver Conference Review.: AIDS Care. 1997 Feb;9(1):103-6. Unique Identifier : AIDSLINE MED/97300907; du Plessis P; York Clinic, Lewisham and Guy's Mental Health NHS Trust, Guys; Hospital, London, UK.
Suicidal behaviours and euthanasia. Vancouver Conference Review.: AIDS Care. 1997 Feb;9(1):106-8. Unique Identifier : AIDSLINE MED/97300908; Starace F; Ogden RD; Department of Primary Care and Population Sciences, Royal Free; Hospital School of Medicine, London, UK.
HIV testing. Vancouver Conference Review.: AIDS Care. 1997 Feb;9(1):108-15. Unique Identifier : AIDSLINE MED/97300909; Miller R; Royal Free Hospital and School of Medicine, London, UK.
Migration and ethnicity issues. Vancouver Conference Review.: AIDS Care. 1997 Feb;9(1):115-9. Unique Identifier : AIDSLINE MED/97300910; Haour-Knipe M; University Institute of Social and Preventive Medicine, Lausanne,; Switzerland.
Social-cultural aspects. Vancouver Conference Review.: AIDS Care. 1997 Feb;9(1):119-23. Unique Identifier : AIDSLINE MED/97300911; Kippax S; National Centre in HIV Social Research Macquarie University, NSW,; Australia.
A dialogue between the sexes. Vancouver Conference Review.: AIDS Care. 1997 Feb;9(1):123-5. Unique Identifier : AIDSLINE MED/97300912; Ankrah EM; Family Health International/AIDSCAP, Arlington, VA 22201, USA.
Participatory evaluation of counselling, medical and social services of The AIDS Support Organization (TASO) in Uganda.: AIDS Care. 1997 Feb;9(1):13-26. Unique Identifier : AIDSLINE MED/97300890; Kaleeba N; Kalibala S; Kaseje M; Ssebbanja P; Anderson S; van Praag E; Tembo G; Katabira E; Joint United Nations Programme on HIV/AIDS, Geneva, Switzerland.; The AIDS Support Organization (TASO) is an indigenous non-governmental organization (NGO) of HIV-infected and affected people in Uganda . TASO provides counselling, social support, medical and nursing care for opportunistic infections at 7 centres affiliated to district hospitals in
Heterogeneity of home care assistance needs of people with AIDS.: AIDS Care. 1997 Feb;9(1):27-33. Unique Identifier : AIDSLINE MED/97300891; Milanese G; Abeni D; Cancelli A; Brancato G; Fabrizi E; Borgia P; Perucci CA; Rocchi G; Division of Infectious Diseases, School of Medicine, Tor Vergata; University, Rome, Italy.; A multidisciplinary home care service for people with AIDS (PWAs) was started in Rome in September 1990. This paper describes the features of the home care service offered by the Associated Health Care Workers Co-operative (OSA), an example of the integration of private and state systems. We detail the types and numb
Health education. Vancouver Conference Review.: AIDS Care. 1997 Feb;9(1):35-9. Unique Identifier : AIDSLINE MED/97300892; Aggleton P; Thomas Coram Research Unit, University of London, UK.
Grief. Vancouver Conference Review.: AIDS Care. 1997 Feb;9(1):39-43. Unique Identifier : AIDSLINE MED/97300893; Folkman S; Chesney M; Center for AIDS Prevention Studies, University of California at; San Francisco 94105, USA.
Asia. Vancouver Conference Review.: AIDS Care. 1997 Feb;9(1):43-9. Unique Identifier : AIDSLINE MED/97300894; Brown T; Program on Population, East-West Center, Honolulu, HI 96848-1601,; USA.
Disclosure. Vancouver Conference Review.: AIDS Care. 1997 Feb;9(1):49-53. Unique Identifier : AIDSLINE MED/97300895; Bor R; Department of Psychology, City University School of Social; Sciences, London, UK.
An epidemic of apprehension: questions about HIV/AIDS to an east African newspaper health advice column.: AIDS Care. 1997 Feb;9(1):5-12. Unique Identifier : AIDSLINE MED/97300889; Asera R; Bagarukayo H; Shuey D; Barton T; Charles A. Dana Center, University of Texas at Austin 78751, USA.; asera@mail.utexas.edu; While AIDS awareness is almost universal in Uganda , cultural values discourage open discussion of sexual behaviour. Thus many questions remain unasked, especially in public. This study managed to analyse some of these queries by examining 1252 letters written spontaneously to a new
Drug use. Vancouver Conference Review.: AIDS Care. 1997 Feb;9(1):53-7. Unique Identifier : AIDSLINE MED/97300896; Des Jarlais DC; Friedman SR; Hagan H; Paone D; Vlahov D; Beth Israel Medical Center, New York, NY 10003, USA.
Interventions--gay men. Vancouver Conference Review.: AIDS Care. 1997 Feb;9(1):57-62. Unique Identifier : AIDSLINE MED/97300897; Flowers P; MRC Medical Sociology Unit, Glasgow, UK.
Adolescence. Vancouver Conference Review.: AIDS Care. 1997 Feb;9(1):62-6. Unique Identifier : AIDSLINE MED/97300898; Elford J; Department of Primary Care and Population Sciences, Royal Free; Hospital School of Medicine, London, UK.
School-based sex education. Vancouver Conference Review.: AIDS Care. 1997 Feb;9(1):66-9. Unique Identifier : AIDSLINE MED/97300899; Wight D; MRC Medical Sociology Unit, Glasgow, UK.
Pregnancy and childbirth. Vancouver Conference Review.: AIDS Care. 1997 Feb;9(1):69-77. Unique Identifier : AIDSLINE MED/97300900; Sherr L; Department of Primary Care and Population Sciences, Royal Free; Hospital School of Medicine, London, UK.
Women's news. Vancouver Conference Review.: AIDS Care. 1997 Feb;9(1):77-82. Unique Identifier : AIDSLINE MED/97300901; Gorna R; Terrence Higgins Trust, London, UK.
Orphans. Vancouver Conference Review.: AIDS Care. 1997 Feb;9(1):82-7. Unique Identifier : AIDSLINE MED/97300902; Foster G; Department of Paediatrics, Mutare Provincial Hospital, Zimbabwe.
Children. Vancouver Conference Review.: AIDS Care. 1997 Feb;9(1):87-91. Unique Identifier : AIDSLINE MED/97300903; Thorne C; Department of Paediatric Epidemiology, Institute of Child Health,; London, UK.
Prisons. Vancouver Conference Review.: AIDS Care. 1997 Feb;9(1):92-5. Unique Identifier : AIDSLINE MED/97300904; Turnbull P; Centre for Research on Drugs and Health Behaviour, University of; London, UK.; Interesting and innovative programmes to tackle the problems associated with HIV/AIDS in prison have been and are being tried throughout the world. However, a number of political, legal and cultural barriers exist hindering the development of effective prevention and care and treatment approaches.
Volunteers. Vancouver Conference Review.: AIDS Care. 1997 Feb;9(1):95-8. Unique Identifier : AIDSLINE MED/97300905; Ross MW; Center for Health Promotion Research and Development, School of; Public Health, University of Texas, Houston 77225, USA.
Natural history. Vancouver Conference Review.: AIDS Care. 1997 Feb;9(1):98-103. Unique Identifier : AIDSLINE MED/97300906; Sabin C; Department of Primary Care and Population Sciences, Royal Free; Hospital School of Medicine, London, UK.
[The AIDS patient in anesthesia]: Anasthesiol Intensivmed Notfallmed Schmerzther. 1997 Feb;32(2):87-97. Unique Identifier : AIDSLINE MED/97245768; Jalowy A; Flesche CW; Lorenz C; Zentrum fur Anasthesiologie, Heinrich-Heine-Universitat,; Dusseldorf.; Treatment of a patient with Acquired Immune Deficiency Syndrome (AIDS) is very challenging, and makes great demands on the anaesthesiologist. Any of an AIDS patient s vital organ systems may be compromised, either by the human immunodeficiency virus (HIV) itself, opportunistic infections, by tumours, or as a result of
Immunity aging. I. The chronic perduration of the thymus acute involution at puberty? Or the participation of the lymphoid organs and cells in fatal physiologic decline? [editorial]: Biomed Pharmacother. 1997;51(2):49-57. Unique Identifier : AIDSLINE MED/97305201; Mathe G; Institut de Cancerologie et d'Immunologie & Hopital Suisse de; Paris, France.; The author has focused the subject on the perduration of puberty thymus involution as a cause of immunity aging, a term in which he does not include senescence. The decrease between immune reactions against HIV1 at 25 years of age and those at 35 is considerable; the decrease is also indirectly revealed by spontaneous
Complementary and alternative medicine and HIV/AIDS. Part I: Issues and context.: J Assoc Nurses AIDS Care. 1997 Jan-Feb;8(1):23-31. Unique Identifier : AIDSLINE MED/97239585; MacIntyre RC; Holzemer WL; Philippek M; Samuel Merritt College, Oakland, CA, USA.; This paper reviews the definitions of complementary and alternative medicine (CAM) and adopts the definition, Complementary and alternative medicine is defined through a social process as those practices that do not form part of the dominant system for managing health and disease (Jonas, 1996, p.1). The authors revi
Coordinating a large multicentered HIV research project.: J Assoc Nurses AIDS Care. 1997 Jan-Feb;8(1):41-50. Unique Identifier : AIDSLINE MED/97239586; Cohen HL; Davis L; Hunter J; Carp D; Geromanos K; Sunkle S; University of California, Los Angeles, USA.; Coordinating a large multicentered pediatric HIV clinical research study is particularly challenging for nurses. The cohort of patients and their families face multiple stressors, which make recruitment and compliance difficult. Additionally, when many departments within the institution are involved, coordination is o
Managing depression among people with HIV disease.: J Assoc Nurses AIDS Care. 1997 Jan-Feb;8(1):51-67. Unique Identifier : AIDSLINE MED/97239587; Valente SM; Saunders JM; University of Southern California, Los Angeles, USA.; Many people with HIV suffer from depression, which responds to antidepressants, counseling, education, and cognitive strategies. Untreated depression hinders treatment compliance and increases risk of suicide. Management and complications of major depression are described. The evaluation of rational suicide is examine
Postexposure prophylaxis after an occupational exposure to HIV.: J Assoc Nurses AIDS Care. 1997 Jan-Feb;8(1):83-7. Unique Identifier : AIDSLINE MED/97239588; Porche DJ
Social support for HIV-infected mothers: relation to HIV care seeking.: J Assoc Nurses AIDS Care. 1997 Jan-Feb;8(1):91-8. Unique Identifier : AIDSLINE MED/97239589; Williams AB; Shahryarinejad A; Andrews S; Alcabes P; Yale School of Nursing, New Haven, CT, USA.; A cross-sectional survey was conducted to identify sources of social support for 92 HIV-seropositive mothers and to examine the relationship between social support and initiation of health care after a positive test for HIV antibody. Main outcome measures were self-reported source and amount of social support and leng
Thymocyte Fas expression is dysregulated in myasthenia gravis patients with anti-acetylcholine receptor antibody.: Blood. 1997 May 1;89(9):3287-95. Unique Identifier : AIDSLINE MED/97275140; Moulian N; Bidault J; Truffault F; Yamamoto AM; Levasseur P; Berrih-Aknin S; CNRS URA 1159 and the Departement de Chirurgie Thoracique,; Hopital Marie-Lannelongue, Le Plessis Robinson, France.; Myasthenia gravis (MG) is a human autoimmune disease mediated by anti-acetylcholine receptor (AChR) antibodies. The thymus is probably the site where the autoimmune response is triggered and maintained. Recent reports have linked various autoimmune disease with defective Fas expression. We thus analyzed Fas expression
Variable immortalizing potential and frequent virus latency in blood-derived T-cell clones infected with human T-cell leukemia virus type I.: Blood. 1997 May 1;89(9):3303-14. Unique Identifier : AIDSLINE MED/97275142; Richardson JH; Hollsberg P; Windhagen A; Child LA; Hafler DA; Lever AM; Department of Medicine, University of Cambridge, United Kingdom.; Human T-cell leukemia virus type I (HTLV-I)-infected T cells expanded in vitro by single-cell cloning provide a unique system for investigating virus-cell interactions in nonimmortalized T cells. By analysis of clones generated randomly from the blood of virus carriers, we confirm that CD4 T cells are the major reserv
Cloning and characterization of exodus, a novel beta-chemokine.: Blood. 1997 May 1;89(9):3315-22. Unique Identifier : AIDSLINE GENBANK/U64197; Hromas R; Gray PW; Chantry D; Godiska R; Krathwohl M; Fife K; Bell GI; Takeda J; Aronica S; Gordon M; Cooper S; Broxmeyer HE; Klemsz MJ; Department of Hematology/Oncology and the Walther Oncology; Center, Indiana University Medical Center, Indianapolis 46202,; USA.; Chemokines are a family of related proteins that regulate leukocyte infiltration into inflamed tissue. Some chemokines such as MIP-1 alpha also inhibit hematopoietic progenitor cell proliferation. Recently, three chemokines, MIP-1 alpha, MIP-1 beta, and RANTES, have been found to significantly decrease human immunodef
Activation of the NF-kappaB pathway by inflammatory stimuli in human neutrophils.: Blood. 1997 May 1;89(9):3421-33. Unique Identifier : AIDSLINE MED/97275156; McDonald PP; Bald A; Cassatella MA; Department of General Pathology, University of Verona, Italy.; Activated neutrophils have the ability to upregulate the expression of many genes, in particular those encoding cytokines and chemokines, and to subsequently release the corresponding proteins. Although little is known to date concerning the regulation of gene transcription in neutrophils, it is noteworthy that many o
Differential effects of interleukin-13 on cytomegalovirus and human immunodeficiency virus infection in human alveolar macrophages.: Blood. 1997 May 1;89(9):3443-50. Unique Identifier : AIDSLINE MED/97275158; Hatch WC; Freedman AR; Boldt-Houle DM; Groopman JE; Terwilliger EF; Division of Experimental Medicine, Beth Israel Deaconess Medical; Center, Harvard Medical School, Boston, MA 02215, USA.; Alveolar macrophages, which form a principal line of defense against a variety of pulmonary pathogens, may themselves be infected by viruses like human immunodeficiency virus-1 (HIV-1), which impair their defensive functions. Interleukin-13 (IL-13), a multifunctional cytokine, has been considered for therapeutic use b
The role of B7 costimulation by murine acute myeloid leukemia in the generation and function of a CD8+ T-cell line with potent in vivo graft-versus-leukemia properties.: Blood. 1997 May 1;89(9):3477-85. Unique Identifier : AIDSLINE MED/97275162; Boyer MW; Vallera DA; Taylor PA; Gray GS; Katsanis E; Gorden K; Orchard PJ; Blazar BR; Department of Pediatrics, University of Minnesota Hospital and; Clinic, Minneapolis, USA.; Relapse is more frequent after autologous than allogeneic bone marrow transplantation (BMT), due in part to lack of T-lymphocyte mediated allogeneic graft-versus-leukemia (GVL) effects. Infusions of leukemia-reactive T cells to patients after autologous BMT may be a means for providing a GVL effect. Costimulation of T
[Prevalence of hepatitis C virus and human immunodeficiency virus infection among female prison inmates in Japan]: Nippon Koshu Eisei Zasshi. 1997 Jan;44(1):55-60. Unique Identifier : AIDSLINE MED/97248940; Nara K; Kawano M; Igarashi M; Department of Emergency and Critical Care Medicine, Jichi Medical; School, Tochigi, Japan.; To investigate the prevalence of hepatitis C virus and human immunodeficiency virus infection in female inmates, 504 out of 513 female inmates in a certain female prison in Japan were tested for anti-hepatitis C virus, anti-hepatitis B virus, anti-hepatitis A virus and anti-human im
Cost of medication therapy in ambulatory HIV-infected patients.: Ann Pharmacother. 1997 Mar;31(3):303-7. Unique Identifier : AIDSLINE MED/97219645; Nykamp D; Barnett CW; Lago M; Parham DL; Fernandez ES; Mercer University School of Pharmacy, Atlanta, GA 30341, USA.; OBJECTIVE: To examine the use and cost associated with prescribed medications as well as the use of over-the-counter medications and nontraditional therapies among ambulatory HIV-infected patients at Ryan White Title IIIb grantee centers. METHODS: Study participants (n = 223) were enrolled from eight centers across th
Prophylaxis of anaphylactoid reaction to antituberculous drugs [letter]: Ann Pharmacother. 1997 Mar;31(3):373-4. Unique Identifier : AIDSLINE MED/97219662; Kevorkian JP; Seroux C; Deharbe S; Salord JM; Bergmann JF
Pharmacotherapy of HIV dementia.: Ann Pharmacother. 1997 Apr;31(4):457-73. Unique Identifier : AIDSLINE MED/97255662; Melton ST; Kirkwood CK; Ghaemi SN; Department of Pharmacy and Pharmaceutics, School of Pharmacy,; Virginia Commonwealth University, Richmond 23298, USA.; OBJECTIVE: To review the clinical presentation and management of cognitive impairment associated with central nervous system HIV type 1 (HIV-1) infection. DATA SOURCES: A MEDLINE search pertaining to HIV-related dementia (HIV-D) and pharmacologic management was performed. Additiona
T cell subsets in immunologically-mediated glomerulonephritis.: Histol Histopathol. 1997 Jan;12(1):241-50. Unique Identifier : AIDSLINE MED/97197763; van Alderwegen IE; Bruijn JA; de Heer E; Leiden University, Department of Pathology, The Netherlands.; Until recently, research on the pathogenesis of glomerulonephritis has been mainly focused on the characterization of humoral immune responses in the initiation of glomerular injury. However, there is a growing recognition that both cellular and humoral immune responses, in varying proportions, are involved in the pat
Single-step purification of recombinant wild-type and mutant HIV-1 reverse transcriptase.: Protein Expr Purif. 1996 Feb;7(1):27-32. Unique Identifier : AIDSLINE MED/96209928; Fletcher RS; Holleschak G; Nagy E; Arion D; Borkow G; Gu Z; Wainberg MA; Parniak MA; Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-; Jewish General Hospital, Montreal, Canada.; We have devised a single-step method that enables purification of HIV-1 recombinant reverse transcriptase directly from bacterial lysates in less than 2 h. Clarified lysates are applied to commercial Q- and S-matrix cartridge columns connected in series. The columns are washed with low-salt buffer to remove unbound pr
Features of the cytokines secreted by adult T cell leukemia (ATL) cells.: Leuk Lymphoma. 1996 May;21(5-6):443-7. Unique Identifier : AIDSLINE MED/97013287; Yamada Y; Ohmoto Y; Hata T; Yamamura M; Murata K; Tsukasaki K; Kohno T; Chen Y; Kamihira S; Tomonaga M; Department of Hematology, Atomic Disease Institute, Nagasaki; University School of Medicine, Japan.; Adult T cell leukemia (ATL) cells show a mature helper-inducer T cell phenotype and are thought to secrete many kinds of cytokines in vivo, complicating the clinical features in these patients. In an attempt to specify the cytokines produced by ATL cells, we measured the cytokine concentration in the culture supernata
The impact of red cell substitutes on the blood service in Japan.: Artif Cells Blood Substit Immobil Biotechnol. 1997 Jan-Mar;25(1-2):53-60. Unique Identifier : AIDSLINE MED/97237148; Sekiguchi S; Hokkaido Red Cross Blood Center, Sapporo, Japan.; The total number of blood donors in 1994 was 6.6 millions, and 200 ml whole blood donation occupied 41.8% of all donations, whereas 400 ml and apheresis donations occupied 35.6%, 22.5% of all donations respectively. From the donated blood, about 8.35 million bags of blood components were prepared and were used for blo
[Surface-active substances in the arsenal of agents against AIDS]: Mikrobiol Z. 1997 Jan-Feb;59(1):87-97. Unique Identifier : AIDSLINE MED/97252110; Krivoshein IuS; Krivorutchenko IuL; Only nucleoside analogues such as zidovudine have been widely used to improve the clinical state of patients with AIDS till now. Their use has a number of eliminations. Nevertheless, the anti-HIV properties of many different substances have been shown. Some of them contain hydrophobic and polar parts of molecules and
HIV infection: the spectrum of symptoms and disease in male and female patients attending a London hospice.: Palliat Med. 1997 Mar;11(2):152-8. Unique Identifier : AIDSLINE MED/97301092; Kelleher P; Cox S; McKeogh M; Antigen Presentation Research Group, Imperial College School of; Medicine at Northwick Park, Harrow, UK.; To delineate the demographic features and clinical profile of male and female individuals utilizing a respite, rehabilitation and hospice centre in London, a retrospective study of patient notes was undertaken. The subjects were 59 male and 59 female HIV patients at first admission to the hospice. The study revealed c
Validity of a decision tree for predicting active pulmonary tuberculosis.: Am J Respir Crit Care Med. 1997 May;155(5):1711-6. Unique Identifier : AIDSLINE MED/97299732; El-Solh A; Mylotte J; Sherif S; Serghani J; Grant BJ; Department of Medicine, State University of New York at Buffalo,; 14215, USA.; The recent outbreaks of multidrug-resistant strains of M. tuberculosis in health care facilities has increased concern over its transmission in health care facilities. Isolation has been recommended for all patients suspected to have tuberculosis even though the feasibility and the cost of this recommendation can be s
Lack of clinical utility of bronchoalveolar lavage cultures for cytomegalovirus in HIV infection.: Am J Respir Crit Care Med. 1997 May;155(5):1723-8. Unique Identifier : AIDSLINE MED/97299734; Mann M; Shelhamer JH; Masur H; Gill VJ; Travis W; Solomon D; Manischewitz J; Stock F; Lane HC; Ognibene FP; Critical Care Medicine Department, Warren G. Magnuson Clinical; Center, National Cancer Institute, National Institutes of Health,; Bethesda, Maryland 20892-1662, USA.; This study assessed the presence of cytomegalovirus ( CMV ) in bronchoalveolar lavage (BAL) in three subpopulations of HIV-infected patients and correlated its presence with clinical status during 3 mo of follow-up. Nineteen as
Effects of neurokinin depletion on airway inflammation induced by chronic antigen exposure.: Am J Respir Crit Care Med. 1997 May;155(5):1739-47. Unique Identifier : AIDSLINE MED/97299737; Tiberio IF; Turco GM; Leick-Maldonado EA; Sakae RS; Paiva SO; do Patrocinio M; Warth TN; Lapa e Silva JR; Saldiva PH; Martins MA; Department of Medicine, Faculty of Medicine, University of Sao; Paulo, Brazil.; We assessed the effects of neurokinin (tachykinin) depletion by capsaicin (CAP) treatment on airway inflammation induced by repeated ovalbumin (OA) aerosol exposures (twice a week for 4 wk) in guinea pigs. The animals were then anesthetized, tracheostomized, mechanically ventilated and challenged with ovalbumin aeroso
Lack of association of induration size with HIV infection among drug users reacting to tuberculin [letter]: Am J Respir Crit Care Med. 1997 May;155(5):1816-7. Unique Identifier : AIDSLINE MED/97299749; Daniel TM
[Ultrasonography of changes in the retroperitoneal vessels and perivascular spaces during retroviral infection: preliminary results]: Sante. 1997 Jan-Feb;7(1):25-31. Unique Identifier : AIDSLINE MED/97241165; N'gbesso RD; N'goan AM; Tahirou K; Diabate K; Keita AK; Service de radiologie, CHU de Yopougon, Cote d'lvoire.; The abdomen in patients with acquired immunodeficiency syndrome (AIDS) is subject to various damage. In AIDS patients, manifestations in the retroperitoneal region, including apparent changes in the pancreas, kidney and lymph nodes, have been well described in the radiological literature. However, abnormalities of the
[Attendance at a health center by clandestine prostitutes in Djibouti]: Sante. 1997 Jan-Feb;7(1):5-10. Unique Identifier : AIDSLINE MED/97241162; Philippon M; Saada M; Kamil MA; Houmed HM; Centre de prophylaxie, Djibouti.; The extent of clandestine prostitution in Djibouti is difficult to evaluate. Due to the secrecy of the prostitutes and often their low level of education, the follow-up of these patients is also difficult. A sexually transmitted disease clinic specialized in the treatment of pros
Gastrointestinal manifestations in pediatric AIDS.: Pediatr Pathol Lab Med. 1997 Mar-Apr;17(2):171-208. Unique Identifier : AIDSLINE MED/97241147; Kahn E; Department of Pathology, North Shore University Hospital,; Manhasset, New York 11030, USA.; The pathologic changes in the gastrointestinal tract of children with AIDS are variable, clinically significant, and reflect multisystemic disease processes. Inflammation, changes in the lymphoid tissue, miscellaneous lesions, and tumors are documented in 58 patients in addition to cases reported in the literature. Cy
Not just another Fab: the crystal structure of a TcR-MHC-peptide complex.: Structure. 1997 Feb 15;5(2):159-63. Unique Identifier : AIDSLINE MED/97184682; Jardetzky T; Department of Biochemistry, Molecular Biology and Cell Biology,; Northwestern University, Evanston, IL 60208, USA.; jardetz@tochtli. biochem.nwu.edu; The structure of a ternary complex formed between a T-cell receptor, a major histocompatibility complex (MHC) protein and a viral peptide provides new insights into the cellular immune response. The results provide a molecular basis for understanding the development of T cells and the reactions leading to transplant r
State hospitals' responses to the sexual behavior of psychiatric inpatients.: Psychiatr Serv. 1997 Mar;48(3):398-9. Unique Identifier : AIDSLINE MED/97210072; Buckley PF; Hyde JL; Northcoast Behavioral Healthcare System, Northfield, OH 44067,; USA.; To determine state psychiatric hospitals responses to sexual behavior among inpatients, the authors sent a questionnaire to the directors of 86 state facilities. Eighty-eight percent of the 57 respondents considered sexual behavior to be a clinical problem. Most had a policy addressing sexual activities among patientb
Bilateral parotid sialolithiasis in a patient with acquired immunodeficiency syndrome and immunoglobulin G multiple myeloma.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997 May;83(5):552-4. Unique Identifier : AIDSLINE MED/97303490; Ottaviani F; Galli A; Lucia MB; Ventura G; Institute of Otolaryngology, Catholic University, Rome, Italy.; Bilateral multiple parotid calculi, which are uncommonly diagnosed in the normal population, have never been reported in patients infected with human immunodeficiency virus. Herein we report a case of bilateral parotid sialolithiasis in a patient who had acquired immunodeficiency syndrome and was affected by multiple b
Immunoregulatory effects of morphine on human lymphocytes.: Clin Diagn Lab Immunol. 1997 Mar;4(2):127-32. Unique Identifier : AIDSLINE MED/97220482; Nair MP; Schwartz SA; Polasani R; Hou J; Sweet A; Chadha KC; Department of Medicine, Buffalo General Hospital, State; University of New York at Buffalo 14203, USA.; It is now well established that parenteral drug abuse is a significant risk factor for contracting human immunodeficiency virus type 1 (HIV-1) infection and subsequently developing AIDS. Earlier studies have shown that morphine can modulate various immune responses and therefore support the premise that morphine is a b
Inter- and intrainstitutional evaluation of automated volumetric capillary cytometry for the quantitation of CD4- and CD8-positive T lymphocytes in the peripheral blood of persons infected with human immunodeficiency virus. Site Investigators and the NIAID New CD4 Technologies Focus Group.: Clin Diagn Lab Immunol. 1997 Mar;4(2):173-9. Unique Identifier : AIDSLINE MED/97220489; O'Gorman MR; Gelman R; Children's Memorial Hospital, Northwestern University Medical; School, Chicago, Illinois 60614, USA.; Volumetric capillary cytometry (VCC) is a new technology that involves the detection and enumeration of dually fluorochrome-labeled cells in a precise volume. We compared the accuracy and precision of VCC with the accuracy and precision of flow cytometry and hematology (F&H) for the measurement of the absolute numb
Lack of association of Borna disease virus and human T-cell leukemia virus type 1 infections with psychiatric disorders among Japanese patients.: Clin Diagn Lab Immunol. 1997 Mar;4(2):189-94. Unique Identifier : AIDSLINE GENBANK/D85768; Kubo K; Fujiyoshi T; Yokoyama MM; Kamei K; Richt JA; Kitze B; Herzog S; Takigawa M; Sonoda S; Department of Neuropsychiatry, Faculty of Medicine, Kagoshima; University, Japan.; Borna disease virus (BDV) infection has been suspected to be a possible etiological factor in human psychiatric disorders and recently in chronic fatigue syndrome. Evidence of the correlation of BDV infection with these disorders remained unclear. Kagoshima is known to be one of the major areas in which human T-cell l
CD69 expression reliably predicts the anti-CD3-induced proliferative response of lymphocytes from human immunodeficiency virus type 1-infected patients.: Clin Diagn Lab Immunol. 1997 Mar;4(2):217-22. Unique Identifier : AIDSLINE MED/97220497; Prince HE; Lape-Nixon M; MRL Reference Laboratory, Cypress, California 90630, USA.; Published studies suggest that mitogenic responses of lymphocytes can be reliably assessed by monitoring the expression of lymphocyte surface CD69 after 24 h of culture with the stimulant. We tested this hypothesis by determining the ability of lymphocyte CD69 expression to predict the outcome (normal or abnormal) of
Immune suppression in calves with bovine immunodeficiency virus.: Clin Diagn Lab Immunol. 1997 Mar;4(2):232-5. Unique Identifier : AIDSLINE MED/97220501; Zhang S; Wood C; Xue W; Krukenberg SM; Chen Q; Minocha HC; Department of Diagnostic Medicine/Pathobiology, College of; Veterinary Medicine, Kansas State University, Manhattan 66506,; USA.; The present study was designed to evaluate the effect of bovine immunodeficiency virus (BIV) infection on immune functions and possible interactions between BIV and other bovine viruses in calves. Ten calves were inoculated intravenously with BIV, and five served as controls. An increased lymphocyte proliferation to B
Effect of L-carnitine treatment in vivo on apoptosis and ceramide generation in peripheral blood lymphocytes from AIDS patients.: Proc Assoc Am Physicians. 1997 Mar;109(2):146-53. Unique Identifier : AIDSLINE MED/97222554; Cifone MG; Alesse E; Di Marzio L; Ruggeri B; Zazzeroni F; Moretti S; Famularo G; Steinberg SM; Vullo E; De Simone C; Department of Experimental Medicine, University of L'Aquila,; Italy.; Lymphocyte apoptosis in HIV-infected individuals may play a role in T-cell depletion and therefore favor progression to AIDS. In this study, we examined the effects of a short-term (5-day) intravenous treatment with L-carnitine (6 g/day) on apoptosis of CD4 and CD8 cells from 10 AIDS patients. L-carnitine administrati
Influence of L-carnitine on CD95 cross-lining-induced apoptosis and ceramide generation in human cell lines: correlation with its effects on purified acidic and neutral sphingomyelinases in vitro.: Proc Assoc Am Physicians. 1997 Mar;109(2):154-63. Unique Identifier : AIDSLINE MED/97222555; Di Marzio L; Alesse E; Roncaioli P; Muzi P; Moretti S; Marcellini S; Amicosante G; De Simone C; Cifone MG; Department of Experimental Medicine, University of L'Aquila,; Italy.; Recently, we examined the effects of a short-term (5-days) intravenous L-carnitine (6 g/die) treatment on apoptosis of CD4 and CD8 cells from 10 AIDS patients. Without inducing side effects, L-carnitine administration has been shown to induce a potent reduction in the percentage of cells undergoing apoptosis, parallel
Natural transmission of bovine leukemia virus in dairy and beef cattle.: Vet Clin North Am Food Anim Pract. 1997 Mar;13(1):107-28. Unique Identifier : AIDSLINE MED/97225376; Hopkins SG; DiGiacomo RF; Seattle-King County Department of Public Health, Washington, USA.; Many potential routes of bovine leukemia virus (BLV) transmission are reviewed in this article. Vertical transmission, in utero, or through colostrum and milk, accounts for a relatively small proportion of infections. Iatrogenic horizontal transmission, through procedures permitting the transfer of blood between cattl
Economics of bovine leukemia virus infection.: Vet Clin North Am Food Anim Pract. 1997 Mar;13(1):129-41. Unique Identifier : AIDSLINE MED/97225377; Pelzer KD; Department of Large Animal Clinical Sciences, Virginia-Maryland; Regional College of Veterinary Medicine, Virginia Polytechnic; Institute and State University, Blacksburg, USA.; A herd infected with bovine leukemia virus suffers a direct economic loss due to clinical lymphosarcoma. A major indirect cost associated with infection is restriction of the sale of animals and germplasma to foreign markets. Reports on the economic effects of infection on production have been variable and are reviewe
Experiences with the New York State Bovine Leukosis Virus Eradication and Certification Program.: Vet Clin North Am Food Anim Pract. 1997 Mar;13(1):143-50. Unique Identifier : AIDSLINE MED/97225378; Brunner MA; Lein DH; Dubovi EJ; Veterinary Diagnostic Laboratory of New York State, College of; Veterinary Medicine, Cornell University, Ithaca, USA.; The Diagnostic Laboratory at the Veterinary College at Cornell University has offered a bovine leukosis virus (BLV) eradication/ certification program since 1985. The program has been popular with purebred breeders since its inception. Recently, many commercial dairymen have also begun participating to reduce the high
Natural and experimental bovine immunodeficiency virus infection in cattle.: Vet Clin North Am Food Anim Pract. 1997 Mar;13(1):151-76. Unique Identifier : AIDSLINE MED/97225379; Snider TG; Hoyt PG; Jenny BF; Coats KS; Luther DG; Storts RW; Battles JK; Gonda MA; Department of Veterinary Pathology, School of Veterinary; Medicine, Louisiana State University, Baton Rouge, USA.; Since 1989, the LSU dairy herd, with its high seroprevalence of BIV, was recognized to have a high incidence of common diseases that reduced the economic viability of the dairy. The herd had a high percentage of cows with encephalitis associated with depression and stupor, alteration of the immune system associated wi
Liaison psychiatry and HIV infection (I): Avoidance coping responses associated with depressive symptoms accompanying somatic complaints.: Psychiatry Clin Neurosci. 1997 Feb;51(1):1-4. Unique Identifier : AIDSLINE MED/97231501; Fukunishi I; Hayashi M; Matsumoto T; Negishi M; Hosaka T; Moriya H; Tokyo Institute of Psychiatry, Japan.; We examined the relationship of somatic complaints to coping behaviors and mood states among 50 HIV-positive patients without AIDS. Although no patients fulfilled the DSM-III-R criteria for mood disorders including major depression, scores for depressive symptoms were significantly higher in the HIV-positive patients
Liaison psychiatry and HIV infection (II): Application of relaxation in HIV positive patients.: Psychiatry Clin Neurosci. 1997 Feb;51(1):5-8. Unique Identifier : AIDSLINE MED/97231502; Fukunishi I; Hosaka T; Matsumoto T; Hayashi M; Negishi M; Moriya H; Tokyo Institute of Psychiatry, Japan.; We examined the efficacy of relaxation techniques in a sample of HIV patients without AIDS in the early stages after infection, by comparing the three groups: relaxation group (progressive muscle relaxation and modified autogenic training); ordinary supportive psychotherapy group, and finally no psychiatric treatment
[Motor neuron disease and HIV]: Rev Neurol. 1997 Apr;25(140):552-4. Unique Identifier : AIDSLINE MED/97288001; Casado I; Gomez M; Carmona C; Garcia-Castanon I; Martin C; Sanchez JF; Seccion de Neurologia, Hospital San Pedro de Alcantara,; Caceres, Espana.; Motor-neuron disease, in particular its commonest form (lateral amyotrophic sclerosis) is a degenerative disease of unknown aetiology and inexorable course with an estimated incidence of 0.4-1.8 per 100,000 inhabitants. In recent years great efforts have been made to discover the aetiopathogenesis of this disorder, st
[HTLV-I myelopathy: presentation of a new case]: Rev Neurol. 1997 Apr;25(140):557-9. Unique Identifier : AIDSLINE MED/97288003; Diaz-Guzman J; Lopez-Valdes E; Varela JM; Ramos A; Benito-Leon J; Garcia-Saiz A; Rodriguez-Vallejo A; Servicio de Neurologia, Hospital Doce de Octubre, Madrid,; Espana.; INTRODUCTION: HTLV-I is a human retrovirus which has been implicated in the genesis of tropical spastic paraparesis (HTLV-I-associated myelopathy). So far five cases of this illness have been detected in Spain , five of them in immigrants. We present a new case in Spain, with a chara
Secondary structure of the nascent 7S L RNA mediates efficient transcription by RNA polymerase III.: RNA. 1997 May;3(5):538-49. Unique Identifier : AIDSLINE MED/97293181; Emde G; Frontzek A; Benecke BJ; Department of Biochemistry, Ruhr-University, Bochum, Germany.; A structural motif at the 5 end of human 7S L (srp) RNA that is recognized specifically by cellular proteins has been identified as an efficient activator of RNA polymerase (pol) III transcription in vivo and in vitro. Mutations affecting three double-stranded regions or a tetranucleotide bulge of this RNA motif resu
A rapid and efficient system for screening HIV-1 Pol mRNA-specific ribozymes.: Can J Microbiol. 1997 Jan;43(1):92-6. Unique Identifier : AIDSLINE MED/97210168; Ramezani A; Marhin W; Weerasinghe M; Joshi S; Department of Medical Genetics and Microbiology, University of; Toronto, ON, Canada.; Hammerhead ribozymes are potentially important tools for suppressing intracellular expression of unwanted RNAs. However, the reports that exist on their activity against different targets have described mixed success. As an initial step towards developing a rapid and effective system for in vivo testing of ribozymes,
Prison AIDS project focuses on peer education [news]: Can Med Assoc J. 1997 May 1;156(9):1261. Unique Identifier : AIDSLINE MED/97290387
Needle-stick concerns [letter]: Can Med Assoc J. 1997 May 1;156(9):1267-8. Unique Identifier : AIDSLINE MED/97290393; Sloan JR
Knowledge of and attitudes to infection control of tattooists at registered premises in Victoria, 1994.: Aust N Z J Public Health. 1997 Feb;21(1):17-22. Unique Identifier : AIDSLINE MED/97286576; Goudey RE; Thompson SC; Department of Human Services, Gippsland Region, Warragul, Vic.; rgoudey@hna.ffh.vic.gov.au; Historically, the relationship between health authorities and tattooists has been marked by suspicion and mutual distrust, with tattooists being stereotyped as having little concern for hygiene, and considered largely ineducable about infection control. In this study, a random sample of tattooists working at one-third
Interpersonal psychotherapy of a depressed, pregnant, HIV-positive woman [clinical conference]: J Psychother Pract Res. 1997 Spring;6(2):165-78. Unique Identifier : AIDSLINE MED/97225294; Swartz HA; Markowitz JC; Spinelli MG; Cornell University Medical College, Columbia University College; of Physicians and Surgeons, New York, USA.
Dermatologic manifestations of human immunodeficiency virus disease.: Lippincotts Prim Care Pract. 1997 Mar-Apr;1(1):50-61. Unique Identifier : AIDSLINE MED/97308590; Kosko DA; Johns Hopkins University, School of Nursing, Baltimore, MD 21205,; USA.; The skin may be the most commonly affected organ in patients with human immunodeficiency virus disease. As the body s natural immune mechanism deteriorates, susceptibility to bacterial, fungal, viral, and parasitic agents increases. This may be manifested in a variety of ways, ranging from pruritus and generalized xer
A 34-year-old woman with odynophagia and weight loss.: Cleve Clin J Med. 1997 May;64(5):245-8. Unique Identifier : AIDSLINE MED/97293509; Kolluri KR; Conwell DL; Cleveland Clinic, Department of Gastroenterology, Cleveland; Clinic Foundation, OH 44195, USA.
A live-virus "suicide" vaccine for human immunodeficiency virus.: Cleve Clin J Med. 1997 May;64(5):269-74. Unique Identifier : AIDSLINE MED/97293512; Kestler HW; Chakrabarti BK; Department of Molecular Biology, Cleveland Clinic, Cleveland; Clinic Foundation, OH 44195, USA.; A vaccine that uses a live, attenuated human immunodeficiency virus (HIV) may offer the best hope of a vaccine against acquired immunodeficiency syndrome (AIDS). A recent improvement should increase the safety of the live-virus approach: a suicide gene inserted into the viral RNA, which causes infected cells to die
Should antibody to hepatitis B core antigen be tested in routine screening of donor corneas for transplant? [see comments]: Cornea. 1997 Mar;16(2):138-45. Unique Identifier : AIDSLINE MED/97225152; Mattern RM; Cavanagh HD; Department of Ophthalmology, University of Texas Southwestern; Medical Center at Dallas 75235-9057, USA.; PURPOSE: A review of the literature on transfusion-transmitted infectious diseases shows that antibody to hepatitis B core antigen (anti-HBc) is not presently viewed as helpful for hepatitis C or hepatitis non-ABC screening of blood donors. Its utility as a screen for hepatitis B or human immunodeficiency virus-1 (HIV
Retreatment tuberculosis cases. Factors associated with drug resistance and adverse outcomes [see comments]: Chest. 1997 May;111(5):1162-7. Unique Identifier : AIDSLINE MED/97293670; Kritski AL; Rodrigues de Jesus LS; Andrade MK; Werneck-Barroso E; Vieira MA; Haffner A; Riley LW; Servico de Pneumologia, Hospital Clementino Fraga Filho, da; Universidade Federal do Rio de Janeiro, Brazil.; STUDY OBJECTIVE: Risk factors associated with treatment failure and multidrug-resistant tuberculosis (MDR-TB) were examined among HIV-seronegative patients who were previously treated for tuberculosis (TB). DESIGN: Prospective, cohort study of patients referred to the study hospital for retreatment of TB between March
The utility of a single sputum specimen in the diagnosis of tuberculosis. Comparison between HIV-infected and non-HIV-infected patients [see comments]: Chest. 1997 May;111(5):1174-9. Unique Identifier : AIDSLINE MED/97293672; Finch D; Beaty CD; Duke University Medical Center, Durham, NC.; STUDY OBJECTIVES: (1) To assess the utility of a single sputum specimen in the evaluation of HIV-infected patients who are suspected of having tuberculosis (TB). (2) To identify radiographic findings that discriminate between HIV-infected patients with TB and those with pneumonia of other causes. DESIGN: Retrospective
Empiric treatments impair the diagnostic yield of BAL in HIV-positive patients.: Chest. 1997 May;111(5):1180-6. Unique Identifier : AIDSLINE MED/97293673; Gracia JD; Miravitlles M; Mayordomo C; Ferrer A; Alvarez A; Bravo C; Vendrell M; Servei de Pneumologia, Hospital General Universitari Vall; d'Hebron, Barcelona, Spain.; OBJECTIVE: To investigate the influence of empiric treatments prior to fiberoptic bronchoscopy (FOB) on the diagnostic yield of BAL in HIV-positive patients with respiratory symptoms. METHOD: We studied 123 consecutive FOBs with BAL in HIV-positive patients; 101 of these patients (82%) had received previous antimicrob
Utility of lactate dehydrogenase vs radiographic severity in the differential diagnosis of Pneumocystis carinii pneumonia.: Chest. 1997 May;111(5):1187-92. Unique Identifier : AIDSLINE MED/97293674; Boldt MJ; Bai TR; Department of Medicine, University of British Columbia, St.; Paul's Hospital, Vancouver, Canada.; STUDY OBJECTIVES: In patients with HIV infection, serum lactate dehydrogenase (LDH) level is commonly stated to be more elevated in Pneumocystis carinii pneumonia (PCP) than in non-PCP. We hypothesized that LDH level reflects radiographic extent and severity of pneumonia rather than P carinii infection specifically an
Alveolar damage in AIDS-related Pneumocystis carinii pneumonia.: Chest. 1997 May;111(5):1193-9. Unique Identifier : AIDSLINE MED/97293675; Benfield TL; Prento P; Junge J; Vestbo J; Lundgren JD; Departments of Infectious Diseases and Pathology, EM Division,; University of Copenhagen, Hvidovre Hospital, Denmark.; OBJECTIVE: Pneumocystis carinii pneumonia is the most common and serious of the pulmonary complications of AIDS. Despite this, many basic aspects in the pathogenesis of HIV-associated P carinii pneumonia are unknown. We therefore undertook a light and electron microscopic study of transbronchial biopsy specimens to co
Intra-hemispheric alpha coherence decreases with increasing cognitive impairment in HIV patients.: Electroencephalogr Clin Neurophysiol. 1997 Apr;102(4):286-94. Unique Identifier : AIDSLINE MED/97291948; Fletcher DJ; Raz J; Fein G; Department of Medical Psychology, San Francisco Veterans Affairs; Medical Center, CA 94121, USA.; Inter-hemispheric and intra-hemispheric canonical coherences in the alpha range between EEG signals collected from frontal and posterior groups of electrodes were estimated for 38 HIV positive subjects and 23 uninfected controls. Neuropsychological testing was used to categorize the degree of cognitive impairment evid
AIDS related neoplasms in Genoa, Italy.: Eur J Epidemiol. 1995 Dec;11(6):609-14. Unique Identifier : AIDSLINE MED/97015009; Gabutti G; Vercelli M; De Rosa MG; Orengo MA; Casella C; Garrone E; Orlandini C; Piersantelli N; Torresin A; Rizzo F; et al; OERMI (Osservatorio Epidemiologico Regionale Malattie Infettive),; Istituto di Igiene e Medicina Preventiva dell'Universita, Genova,; Italy.; The study defines the epidemiological characteristics of HIV-infection in the population of Genoa and estimates the entity of AIDS-cancer association. The cohort includes 317 subjects resident in the Municipality of Genoa, aged above 14 years and notified prior to 31 December 1991 and/or dead from AIDS in the period 1
A seroepidemiologic survey of immunity against poliomyelitis in a group of HIV positive and HIV negative drug addicts.: Eur J Epidemiol. 1995 Dec;11(6):693-5. Unique Identifier : AIDSLINE MED/97015021; Pregliasco F; Minolfi V; Boschin A; Andreassi A; Profeta ML; Institute of Virology, University of Milan, Italy.; In a seroepidemiological study performed to investigate immunity against poliomyelitis in a population of drug addicts in a rehabilitative residential centre we demonstrated a widespread lack of poliovirus neutralizing antibodies. This was more evident in the HIV positive subjects, 27% of whom were seronegative for po
Absence of HIV-1 and HIV-2 infection in different populations from Alexandria, Egypt [letter]: Eur J Epidemiol. 1995 Dec;11(6):711-2. Unique Identifier : AIDSLINE MED/97015026; Renganathan E; Quinti I; El Ghazzawi E; Kader O; El Sherbini I; Gamil F; Rocchi G
Is there a place for intrinsic asthma as a distinct immunopathological entity? [editorial; comment]: Eur Respir J. 1997 Mar;10(3):513-5. Unique Identifier : AIDSLINE MED/97225706; Kroegel C; Jager L; Walker C
Radiology of pulmonary turberculosis and human immunodeficiency virus infection in Gulu, Uganda.: Eur Respir J. 1997 Mar;10(3):615-8. Unique Identifier : AIDSLINE MED/97225724; Awil PO; Bowlin SJ; Daniel TM; Dept of Epidemiology and Biostatistics and Center for; International Health, Case Western Reserve University School of; Medicine, Cleveland, Ohio 44106, USA.; Pulmonary tuberculosis is a major complication of human immunodeficiency virus (HIV) infection. The radiographic manifestations of pulmonary tuberculosis in HIV-infected patients are not typical of those seen in immunologically normal individuals. We sought to determine whether these manifestations provide clues to th
The increasing prevalence of HIV-1 and HIV-2 infections in a low risk antenatal population in south west Nigeria.: Int J Gynaecol Obstet. 1997 Mar;56(3):271-3. Unique Identifier : AIDSLINE MED/97272455; Obisesan KA; Olaleye OD; Adeyemo AA; Department of Obstetrics and Gynaecology, College of Medicine,; University of Ibadan, Nigeria.
T cell receptor-zeta and granzyme B expression in mononuclear cell infiltrates in normal colon mucosa and colon carcinoma [see comments]: Gut. 1997 Jan;40(1):113-9. Unique Identifier : AIDSLINE MED/97300566; Mulder WM; Bloemena E; Stukart MJ; Kummer JA; Wagstaff J; Scheper RJ; Department of Pathology, Free University Hospital, Amsterdam, The; Netherlands.; BACKGROUND: Whereas the presence of a lymphoid infiltrate has been associated with a favourable prognosis in colorectal carcinoma, the proliferative and cytotoxic responses of freshly isolated tumour infiltrating lymphocytes are frequently impaired. In mice, tumour induced immune suppression has been associated with a
Bone marrow T-cell subsets in patients with monoclonal gammopathies: correlation with clinical stage and disease status.: Haematologica. 1997 Jan-Feb;82(1):43-6. Unique Identifier : AIDSLINE MED/97261047; Corso A; Castelli G; Pagnucco G; Lazzarino M; Bellio L; Klersy C; Bernasconi C; Institute of Hematology, University of Pavia, Italy.; BACKGROUND AND OBJECTIVE: The existence of an imbalance in T-cell subpopulations in patients (pts) affected by monoclonal gammopathies (MG) has been well established. This imbalance might be correlated with different control of plasma cell growth and, particularly in MM, with the severity of the disease. The aim of th
[Human herpesvirus-6: a new member of the herpesvirus family, a threat to AIDS, organ-transplanted and other immune deficient patients]: Harefuah. 1997 Mar 2;132(5):346-50. Unique Identifier : AIDSLINE MED/97298431; Kenigsberg S; Bantov J; Rager-Zisman B
[Growth factor allows longer survival in HIV patients (news)]: Fortschr Med. 1997 Feb 28;115(6):14, 16. Unique Identifier : AIDSLINE MED/97246333; Aulehla S
[Mechanism of neuronal damage in AIDS]: Hokkaido Igaku Zasshi. 1997 Jan;72(1):37-41. Unique Identifier : AIDSLINE MED/97240925; Nagashima K; Department of Pathology, Hokkaido University School of Medicine,; Sapporo, Japan.; Neurologic problems in AIDS are usually caused by opportunistic infections or secondary malignancy of the central nervous system (CNS), but brain damage occurs primarily as the result of HIV infection in CNS. In one of the typical opportunistic virus infections of CNS, progressive multifocal leukoencephalopathy (PML),
Physiology and pathophysiology of dendritic cells.: Hum Pathol. 1997 May;28(5):563-79. Unique Identifier : AIDSLINE MED/97302344; Wright-Browne V; McClain KL; Talpaz M; Ordonez N; Estrov Z; Department of Bioimmunotherapy, University of Texas, M.D.; Anderson Cancer Center, Houston, USA.; Dendritic cells are antigen-presenting cells derived from the hematopoietic stem cell. The dendritic cell family includes Langerhans cells (CD1a-positive dendritic cells of the skin), and antigen-presenting cells that are found in the lymphoreticular system and throughout the organ parenchyme. Dendritic cells play a
Pathological and immunophenotypic features of adult non-Hodgkin's lymphomas by age group.: Hum Pathol. 1997 May;28(5):580-7. Unique Identifier : AIDSLINE MED/97302345; Carbone A; Franceschi S; Gloghini A; Russo A; Gaidano G; Monfardini S; Division of Pathology, Istituto Nazionale di Ricovero e Cura a; Carattere Scientifico, Aviano, Italy.; To elucidate age-related differences in non-Hodgkin s lymphoma (NHL), the authors evaluated 950 consecutive, human immunodeficiency virus-negative patients (age range, 15 to 96 years) observed between July 1988 and June 1995 in the same Italian cancer institute. Patients were group
In vivo molecular analysis of cytokines in a murine model of ocular onchocerciasis. I. Up-regulation of IL-4 and IL-5 mRNAs and not IL-2 and IFN gamma mRNAs in the cornea due to experimental interstitial keratitis.: Immunol Lett. 1996 Dec 1;54(1):59-64. Unique Identifier : AIDSLINE MED/97182844; Chakravarti B; Lagoo-Deenadayalan S; Parker JS; Whitfield DR; Lagoo A; Chakravarti DN; Department of Medicine, University of Alabama, Birmingham, USA.; Sclerosing keratitis is the major cause of blindness due to onchocerciasis which results from chronic infection with the filarial parasite Onchocerca volvulus. Using a murine model of onchocercal sclerosing keratitis, we have demonstrated previously that predominantly (> 85%) CD3 + /CD4+ T-cells as well as the
Acute intensive interval training and in vitro t-lymphocyte function.: Int J Sports Med. 1997 Feb;18(2):130-5. Unique Identifier : AIDSLINE MED/97236391; Hinton JR; Rowbottom DG; Keast D; Morton AR; Department of Biomedical Science, Anglia Polytechnic University,; Cambridge, United Kingdom.; Five male endurance-trained runners completed an interval running session of 15 x 1-min intervals at 95% VO2 max. Venous blood samples were collected pre-exercise and then immediately, 30- and 60-minutes post-exercise. The response of cultures of total lymphocytes to mitogen (phytohaemagglutinin) were significantly re
[Mollusca contagiosa in HIV infection. Clinical manifestation, relation to immune status and prognostic value in 39 patients]: Hautarzt. 1997 Feb;48(2):103-9. Unique Identifier : AIDSLINE MED/97245861; Husak R; Garbe C; Orfanos CE; Universitats-Hautklinik und Poliklinik, Klinikum Benjamin; Franklin, Freien Universitat, Berlin.; Mollusca contagiosa predominantly affect children; their occurrence in adults is rare. In recent years many descriptions of mollusca contagiosa in immunosuppressed patients, mostly in HIV-infected individuals, have appeared. We analysed the occurrence of mollusca contagiosa in a large group of HIV-patients and examine
[Generalized Mycobacterium avium-intracellulare infection due to immunosuppressive therapy of paraneoplastic dermatomyositis]: Hautarzt. 1997 Feb;48(2):118-21. Unique Identifier : AIDSLINE MED/97245864; Schaller M; Korting HC; Meurer M; Schirren CG; Dermatologische Klinik und Poliklinik,; Ludwig-Maximilians-Universitat, Munchen.; The ubiquitous Mycobacterium avium-intracellulare (MAI) is the most frequent cause of disseminated atypical mycobacteriosis in AIDS patients. MAI infections may develop in patients with other acquired immune defects, such as connective tissue disorders. In adults, the gastrointestinal and respiratory systems are most
Identification of direct repeat 4 as a positive regulatory element for the human TR4 orphan receptor. A modulator for the thyroid hormone target genes.: J Biol Chem. 1997 May 2;272(18):12215-20. Unique Identifier : AIDSLINE MED/97277374; Lee YF; Pan HJ; Burbach JP; Morkin E; Chang C; Comprehensive Cancer Center, University of Wisconsin, Madison,; Wisconsin 53792, USA.; While the TR4 orphan receptor (TR4) is able to repress the expression of its target genes via its interaction with the direct repeat 1-hormone response element (DR1-HRE) and DR2-HRE, we now report that TR4 can also induce the transcriptional activity of the reporter gene containing a DR4-HRE via chloramphenicol acetyl
Inhibition of human immunodeficiency virus type 1 replication by a cellular transcriptional factor MBP-1.: J Cell Biochem. 1997 Mar 15;64(4):565-72. Unique Identifier : AIDSLINE MED/97247782; Ray RB; Srinivas RV; Department of Internal Medicine, St. Louis University, Missouri; 63110-0250, USA. Rayrb@sluvca.slu.edu; A cellular transcriptional factor initially identified as the c-myc promoter binding protein (MBP-1) was subsequently characterized as a cell regulatory protein with multifunctional activities. In this study, the role of MBP-1 on human immunodeficiency virus type-1 (HIV-1) transcriptional activity was investigated. MB
HIV vaccines: problems and prospects.: Hosp Pract (Off Ed). 1997 May 15;32(5):125-8, 131-40. Unique Identifier : AIDSLINE MED/97297674; Johnston MI; International AIDS Vaccine Initiative, Washington, DC, USA.; Several lines of evidence now argue strongly that a successful HIV vaccine does not need to block infection completely. It has to mimic what already occurs in a minority of unvaccinated individuals--namely, rapid clearance of infection or reduction of viral load to a level that does not produce symptoms or permit tran
Evaluation of the recombinant 38-kilodalton antigen of Mycobacterium tuberculosis as a potential immunodiagnostic reagent.: J Clin Microbiol. 1997 Mar;35(3):553-7. Unique Identifier : AIDSLINE MED/97193802; Wilkinson RJ; Haslov K; Rappuoli R; Giovannoni F; Narayanan PR; Desai CR; Vordermeier HM; Paulsen J; Pasvol G; Ivanyi J; Singh M; MRC Tuberculosis and Related Infections Unit, Royal Postgraduate; Medical School, Hammersmith Hospital, London, United Kingdom.; The diagnosis of infection caused by Mycobacterium tuberculosis is of increased public health concern following increases in the number of cases in developed countries and major increases in developing countries associated with the spread of human immunodeficiency virus (HIV) infection. The specificity of purified pro
Deterioration of detectable human immunodeficiency virus serum p24 antigen in samples stored for batch testing.: J Clin Microbiol. 1997 Mar;35(3):631-5. Unique Identifier : AIDSLINE MED/97193817; Lathey JL; Marschner IC; Kabat B; Spector SA; Department of Pediatrics, University of California, San Diego, La; Jolla 92093-0672, USA. jlathey@ucsd.edu; Virologic measurements are becoming important surrogate markers for therapeutic efficacy in clinical trials with human immunodeficiency virus (HIV)-infected subjects. One such marker which is inexpensive and easily evaluated is the HIV p-24 antigen. To determine the storage stability of p24 antigen assayed by enzyme-l
Specific PCR assay for direct detection of intestinal microsporidia Enterocytozoon bieneusi and Encephalitozoon intestinalis in fecal specimens from human immunodeficiency virus-infected patients.: J Clin Microbiol. 1997 Mar;35(3):652-5. Unique Identifier : AIDSLINE GENBANK/U09929; Ombrouck C; Ciceron L; Biligui S; Brown S; Marechal P; van Gool T; Datry A; Danis M; Desportes-Livage I; Centre Hospitalo-Universitaire de la Pitie-Salpetriere, Unite; INSERM 313, Paris, France.; A routine assay based on the PCR was developed for the detection of Enterocytozoon bieneusi and Encephalitozoon intestinalis in fecal samples. Two oligonucleotide primer pairs from a conserved region in the small-subunit rRNA genes of E. bieneusi (primer pair V1 and EB450) and E. intestinalis (primer pair V1 and SI500
Identification of various medically important Candida species in clinical specimens by PCR-restriction enzyme analysis.: J Clin Microbiol. 1997 Mar;35(3):667-72. Unique Identifier : AIDSLINE GENBANK/X97681; Morace G; Sanguinetti M; Posteraro B; Lo Cascio G; Fadda G; Istituto di Microbiologia, Universita Cattolica Sacro Cuore,; Rome, Italy.; A single primer pair amplifying a cytochrome P-450 lanosterol-14 alpha-demethylase (L1A1) gene fragment that encodes a highly conserved region was used to detect yeast DNA in clinical specimens. Positive PCR products were obtained from genomic DNAs of Candida albicans, C. parapsilosis, C. tropicalis, C. guilliermondii
Simple diagnosis of Encephalitozoon sp. microsporidial infections by using a panspecific antiexospore monoclonal antibody.: J Clin Microbiol. 1997 Mar;35(3):724-9. Unique Identifier : AIDSLINE MED/97193835; Enriquez FJ; Ditrich O; Palting JD; Smith K; Department of Veterinary Science and Microbiology, University of; Arizona, Tucson 85721, USA.; Microsporidia (phylum Microsproa) have recently become recognized as common opportunistic protozoans in the United States and worldwide, particularly affecting immunodeficient patients. Microsporidian organisms within the genus Encephalitozoon are the cause of nephrologic, ophthalmic,
Uniform staining of Cyclospora oocysts in fecal smears by a modified safranin technique with microwave heating.: J Clin Microbiol. 1997 Mar;35(3):730-3. Unique Identifier : AIDSLINE MED/97193836; Visvesvara GS; Moura H; Kovacs-Nace E; Wallace S; Eberhard ML; Division of Parasitic Diseases, National Cancer for Infectious; Diseases, Centers for Disease Control and Prevention, Atlanta,; Georgia 30341-3724, USA. gsvl@ciddpd2.em.cdc.gov; Cyclospora, a coccidian protist, is increasingly being identified as an important, newly emerging parasite that causes diarrhea, flatulence, fatigue, and abdominal pain leading to weight loss in immunocompetent persons with or without a recent travel history as well as in patients with AIDS. Modified Kinyoun s acid-fa
Restriction enzyme analysis of the virulence plasmids of VapA-positive Rhodococcus equi strains isolated from humans and horses.: J Clin Microbiol. 1997 Mar;35(3):738-40. Unique Identifier : AIDSLINE MED/97193839; Nicholson VM; Prescott JF; Department of Pathobiology, University of Guelph, Ontario,; Canada.; Restriction enzyme digestion patterns of the large virulence plasmids of 8 human and 37 foal isolates of virulence-associated protein (VapA)-positive Rhodococcus equi strains from different sources were compared. Foal isolates came from five continents. Digestion with EcoRI divided these plasmids into three closely re
Genetic relatedness and diversity of Cryptococcus neoformans strains in the Maltese Islands.: J Clin Microbiol. 1997 Mar;35(3):751-5. Unique Identifier : AIDSLINE MED/97193842; Lo Passo C; Pernice I; Gallo M; Barbara C; Luck FT; Criseo G; Pernice A; Istituto di Microbiologia, Facolta di Scienze, Universita di; Messina, Italy.; The genetic relatedness of clinical and environmental Cryptococcus neoformans strains in the Maltese Islands was investigated by randomly amplified polymorphic DNA fingerprinting with four primers. The clinical strains isolate over the course of 1 year from AIDS patients showed identical fingerprints. The electrophore
Standardized peripheral blood mononuclear cell culture assay for zidovudine susceptibility testing of clinical human immunodeficiency virus type 1 isolates: effect of reducing the numbers of replicates and concentrations.: J Clin Microbiol. 1997 Mar;35(3):756-8. Unique Identifier : AIDSLINE MED/97193843; Marschner IC; Mayers DL; Erice A; Smeaton L; Johnson VA; Richman DD; Reichelderfer P; Japour AJ; Center for Biostatistics in AIDS Research, Harvard School of; Public Health, Boston, Massachusetts 02115, USA.; marsch@sdac.harvard.edu; Zidovudine susceptibility was assessed for 525 clinical human immunodeficiency virus type 1 isolates, before and after reducing the number of replicates and zidovudine concentrations in the standardized consensus peripheral blood mononuclear cell culture assay. We conclude that omitting the 0.001 microM concentration
Recurrent CDC group IVc-2 bacteremia in a human with AIDS.: J Clin Microbiol. 1997 Mar;35(3):780-2. Unique Identifier : AIDSLINE MED/97193850; Anderson RR; Warnick P; Schreckenberger PC; Department of Pathology, University of Illinois Medical Center,; Chicago 60612-7312, USA.; A 30-year-old man with AIDS developed separate episodes of bacteremia with multiple organisms including CDC group IVc-2, related to an indwelling central venous catheter. Recovery at each interval followed antibiotic therapy and replacement of the central venous access. This is the first reported case of infection wit
The Honduran human immunodeficiency virus type 1 (HIV-1) epidemic is dominated by HIV-1 subtype B as determined by V3 domain sero- and genotyping.: J Clin Microbiol. 1997 Mar;35(3):783-4. Unique Identifier : AIDSLINE MED/97193851; Lara C; Sallberg M; Johansson B; de Rivera IL; Sonnerborg A; Division of Clinical Virology, Karolinska Institute, Huddinge; University Hospital, Sweden.; The distribution of subtypes A through F of human immunodeficiency virus type 1 (HIV-1) in Honduras was analyzed in 120 HIV-1 positive serum samples by V3 peptide serotyping and HIV-1 cDNA sequencing. In the Honduran HIV-1 epidemic,
Detection of the soluble form of the Fas molecule in patients with multiple sclerosis and human T-lymphotropic virus type I-associated myelopathy.: J Neuroimmunol. 1997 May;75(1-2):141-6. Unique Identifier : AIDSLINE MED/97288269; Inoue A; Koh CS; Sakai T; Yamazaki M; Yanagisawa N; Usuku K; Osame M; Department of Medicine (Neurology), Shinshu University School of; Medicine, Matsumoto, Japan.; We evaluated the presence of soluble Fas molecule (sFas) in the cerebrospinal fluids (CSF) and the sera of patients with multiple sclerosis (MS) or human T-lymphotropic virus type I (HTLV-I) associated myelopathy (HAM) using an enzyme-linked immunosorbent assay (ELISA). Patients with multiple sclerosis in the active p
Protective care-receiving: the active role of care-recipients.: J Adv Nurs. 1997 Mar;25(3):532-40. Unique Identifier : AIDSLINE MED/97235132; Russell CK; Bunting SM; Gregory DM; University of Tennessee, Memphis, College of Nursing 38163, USA.; Historical and contemporary conceptualizations of caregiving have not addressed the active role of care recipients within caregiver-care-recipient relationships. Using an interpretive synthesis method, the authors developed the concept of protective care-receiving from three qualitative studies of different groups of
The politics of sex research and constructions of female sexuality: what relevance to sexual health work with young women?: J Adv Nurs. 1997 Mar;25(3):615-25. Unique Identifier : AIDSLINE MED/97235142; Few C; By examining the relationship between the cultural construction of female sexuality and the lack of potential for many young heterosexual women to be truly sexually healthy this paper submits that messages for women within HIV prevention programmes can be confused, confining and at times dangerous to women s health an
Serum interleukin 4 and interleukin 10 levels in patients with chronic hepatitis C virus infection.: J Hepatol. 1997 Mar;26(3):471-8. Unique Identifier : AIDSLINE MED/97230073; Reiser M; Marousis CG; Nelson DR; Lauer G; Gonzalez-Peralta RP; Davis GL; Lau JY; Department of Medicine, University of Florida, Gainesville 32610,; USA.; BACKGROUND/AIMS: Immune-mediated mechanisms are believed to play an important pathogenetic role in chronic hepatitis C virus infection. Interleukin 4 (IL-4) and IL-10 are secreted by T helper-2 type cells (Th2) which may downregulate cell-mediated immune effector mechanisms important in the host defense against intrac
Clinical presentation of GB-C virus infection in drug abusers with chronic hepatitis C.: J Hepatol. 1997 Mar;26(3):498-502. Unique Identifier : AIDSLINE MED/97230077; Goeser T; Seipp S; Wahl R; Muller HM; Stremmel W; Theilmann L; Department of Internal Medicine, University of Heidelberg,; Germany.; BACKGROUND/AIMS: Recently, the hepatitis GB-C virus (GBV-C) has been identified as another virus potentially causing chronic hepatitis. Although high rates of coinfection are emerging in drug addicts with chronic hepatitis C virus infection, no detailed data on clinical presentation are available. Therefore, co-infect
Class I- and class II-reactive TCRs coexpressed on CD4+ T cells both trigger CD4/CD8-shared and CD4-unique functions.: J Immunol. 1997 May 15;158(10):4533-42. Unique Identifier : AIDSLINE MED/97289559; Asnagli H; Schmitt-Verhulst AM; Guimezanes A; Center for Immunology, INSERM-CNRS of Marseille-Luminy, France.; CD4+ and CD8+ T cells emerge from thymic selection expressing a TCR restricted by MHC class II (TCRII) and MHC class I (TCRI), and upon Ag stimulation develop respectively into Th and CTL effector cells. The influence of thymic differentiation and antigenic stimulation on the determination of T cell functions was stud
Human peptide transporter deficiency: importance of HLA-B in the presentation of TAP-independent EBV antigens.: J Immunol. 1997 May 15;158(10):4555-63. Unique Identifier : AIDSLINE MED/97289562; de la Salle H; Houssaint E; Peyrat MA; Arnold D; Salamero J; Pinczon D; Stevanovic S; Bausinger H; Fricker D; Gomard E; Biddison W; Lehner P; UytdeHaag F; Sasportes M; Donato L; Rammensee HG; Cazenave JP; Hanau D; Tongio MM; Bonneville M; Histocompatibility Laboratory, Contract for Young Research Unit; INSERM 94-03 and INSERM Unit 311, Blood Transfusion; Establishment, Strasbourg, France.; Two siblings with a peptide TAP deficiency were recently described. Despite poor cell surface expression of HLA class I molecules, these patients were not unusually susceptible to viral infections. The majority of the cell surface-expressed class I molecules were HLA-B products as assessed by cytofluorometry and bioch
T cell deletion induced by chronic infection with mouse mammary tumor virus spares a CD25-positive, IL-10-producing T cell population with infectious capacity.: J Immunol. 1997 May 15;158(10):4642-53. Unique Identifier : AIDSLINE MED/97289571; Papiernik M; do Carmo Leite-de-MoraesM; Pontoux C; Joret AM; Rocha B; Penit C; Dy M; INSERM Unit 345, Necker Institute, Paris, France.; We found that T cells recognizing viral superantigen (vSAG) can be subdivided into two distinct functional subsets based on IL-2R alpha (CD25) expression. CD4+Vbeta6+CD25- and CD4+Vbeta6+CD25+ T cells were sensitive to vSAG activation. When obtained from BALB/c(SW) mice, both subsets were infected and capable to induc
CD16-expressing CD8alpha alpha+ T lymphocytes in the intestinal epithelium: possible precursors of Fc gammaR-CD8alpha alpha+ T cells.: J Immunol. 1997 May 15;158(10):4678-87. Unique Identifier : AIDSLINE MED/97289575; She J; Simpson SJ; Gupta A; Hollander G; Levelt C; Liu CP; Allen D; van Houten N; Wang B; Terhorst C; Division of Immunology, Beth Israel Hospital, Boston, MA 02115,; USA.; T lymphocytes normally express their Ag receptors in association with the CD3 proteins, which include CD3zeta. In CD3zeta eta(null) mice thymic and peripheral T lymphocytes do not express the TCR/CD3 complex on their surface due to retention in the endoplasmic reticulum of the remaining polypeptide chains. However, in
Impaired lymphokine secretion in anergic CD4+ T cells leads to defective help for B cell growth and differentiation.: J Immunol. 1997 May 15;158(10):4704-13. Unique Identifier : AIDSLINE MED/97289578; Telander DG; Mueller DL; The Department of Medicine and Center for Immunology, University; of Minnesota Medical School, Minneapolis 55455, USA.; The ability of anergic helper T cells to interact with resting B cells was examined in vitro. B cell growth and differentiation in cocultures were found to be dependent on the expression of CD40 ligand (CD40L) on the cloned T cells, and the expression of this molecule was only marginally blocked by the induction of an
Development of effector CD8+ T cells in contact hypersensitivity occurs independently of CD4+ T cells.: J Immunol. 1997 May 15;158(10):4721-8. Unique Identifier : AIDSLINE MED/97289580; Xu H; Banerjee A; Dilulio NA; Fairchild RL; Department of Immunology, Cleveland Clinic Foundation, OH 44195,; USA.; Contact hypersensitivity (CHS) is a T cell-mediated response to hapten sensitization of the epidermis. Recent results from this laboratory indicated that hapten sensitization induces two populations of hapten-reactive T cells: CD8+ T cells producing IFN-gamma, which mediate the response, and CD4+ T cells producing IL-
In infection with Schistosoma mansoni, B cells are required for T helper type 2 cell responses but not for granuloma formation.: J Immunol. 1997 May 15;158(10):4832-7. Unique Identifier : AIDSLINE MED/97289593; Hernandez HJ; Wang Y; Stadecker MJ; Department of Pathology, Tufts University School of Medicine,; Boston, MA 02111, USA.; The immune response and immunopathologic manifestations in schistosomiasis are largely dependent on Ag-specific CD4+ Th cells. In turn, the stimulatory/regulatory function of the Th cells is dependent on signals emanating from accessory cells. B cells are capable of functioning as accessory cells, and their role in ex
Crucial role of CD8-positive lymphocytes in glomerular expression of ICAM-1 and cytokines in crescentic glomerulonephritis of WKY rats.: J Immunol. 1997 May 15;158(10):4978-83. Unique Identifier : AIDSLINE MED/97289612; Fujinaka H; Yamamoto T; Feng L; Kawasaki K; Yaoita E; Hirose S; Goto S; Wilson CB; Uchiyama M; Kihara I; Department of Pathology, Institute of Nephrology, Niigata; University School of Medicine, Japan.; CD8-positive lymphocytes (CD8+ lym) and ICAM-1/LFA-1 interaction have been implicated in the glomerular accumulation of monocytes/macrophages (Mo/Mphi) and crescent formation in antiglomerular basement membrane (anti-GBM) glomerulonephritis of WKY rats. In the present study, the role of CD8+ lym in the expression of I
Vascular endothelial growth factor is a potent angiogenic factor in AIDS-associated Kaposi's sarcoma-derived spindle cells.: J Immunol. 1997 May 15;158(10):4992-5001. Unique Identifier : AIDSLINE MED/97289614; Nakamura S; Murakami-Mori K; Rao N; Weich HA; Rajeev B; Institute of Molecular Medicine, Huntington Memorial Hospital,; Pasadena, CA 91105, USA.; Angiogenesis is one of the most important features of AIDS-associated Kaposi s sarcoma (AIDS-KS). Our studies suggested that spindle-shaped AIDS-KS cells from various AIDS-KS lesions play important roles in the development of KS lesions. Basic fibroblast growth factor (bFGF) has been reported to be a predominant angio
Evidence of presentation of multiple HIV-1 cytotoxic T lymphocyte epitopes by HLA-B*3501 molecules that are associated with the accelerated progression of AIDS.: J Immunol. 1997 May 15;158(10):5026-34. Unique Identifier : AIDSLINE MED/97289618; Tomiyama H; Miwa K; Shiga H; Moore YI; Oka S; Iwamoto A; Kaneko Y; Takiguchi M; Department of Tumor Biology, Institute of Medical Science,; University of Tokyo, Minato-ku, Japan.; We recently showed HLA-B35-restricted CTL activity for 10 HIV-1 epitopes in PBL from two HIV-1-infected individuals. In the present study, we established CTL clones specific for nine of these HIV-1 epitopes to confirm these HLA-B35-restricted epitopes. The specific CTL clones effectively killed the HLA-B*3501-positive
Differential infection of CD34+ cell-derived dendritic cells and monocytes with lymphocyte-tropic and monocyte-tropic HIV-1 strains.: J Immunol. 1997 May 15;158(10):5035-42. Unique Identifier : AIDSLINE MED/97289619; Warren MK; Rose WL; Cone JL; Rice WG; Turpin JA; Poietic Technologies, Inc., Gaithersburg, MD 20878, USA.; Monocytes and dendritic cells are infected by HIV-1 and subsequently produce virions that initiate further rounds of infection. Current methods for the isolation and study of dendritic cells are hampered by the low frequency of these cells and contamination with other cell types. A two-step culture method was devised
The use of computer-assisted video image analysis for the quantification of CD8+ T lymphocytes producing tumor necrosis factor alpha spots in response to peptide antigens.: J Immunol Methods. 1997 Apr 25;203(2):141-52. Unique Identifier : AIDSLINE MED/97293913; Herr W; Linn B; Leister N; Wandel E; Meyer zum Buschenfelde KH; Wolfel T; Medizinische Klinik und Poliklinik, Johannes; Gutenberg-Universitat Mainz, Germany.; Enzyme-linked immunospot (ELISPOT) analysis is a sensitive technique for the detection and quantification of single T lymphocytes forming cytokine spots after antigen contact in vitro. Herein computer-assisted video image analysis (CVIA) was applied to automatically determine the number and size of tumor necrosis fact
The relationship between serum human immunodeficiency virus type 1 (HIV-1) RNA level, CD4 lymphocyte percent, and long-term mortality risk in HIV-1-infected children. National Institute of Child Health and Human Development Intravenous Immunoglobulin Clinical Trial Study Group.: J Infect Dis. 1997 May;175(5):1029-38. Unique Identifier : AIDSLINE MED/97275169; Mofenson LM; Korelitz J; Meyer WA 3rd; Bethel J; Rich K; Pahwa S; Moye J Jr; Nugent R; Read J; Pediatric, Adolescent and Maternal AIDS Branch, Center for; Research for Mothers and Children, National Institute of Child; Health and Human Development, National Institutes of Health,; Rockville, MD 20852, USA.; Association of human immunodeficiency virus type 1 (HIV-1) RNA level, CD4 cell percent, and mortality was examined in stored sera from 254 infected children in an intravenous immunoglobulin infection prophylaxis trial. Ninety-two children (36.2%) died (41 during the study, 51 during long-term follow-up). The geometric
Evaluation of pharmacokinetics, safety, tolerance, and activity of combination of zalcitabine and zidovudine in stable, zidovudine-treated pediatric patients with human immunodeficiency virus infection. AIDS Clinical Trials Group Protocol 190 Team.: J Infect Dis. 1997 May;175(5):1039-50. Unique Identifier : AIDSLINE MED/97275170; Bakshi SS; Britto P; Capparelli E; Mofenson L; Fowler MG; Rasheed S; Schoenfeld D; Zimmer B; Frank Y; Yogev R; Jimenez E; Salgo M; Boone G; Pahwa SG; North Shore University Hospital-Cornell University Medical; College, Manhasset, New York, USA.; A double-blind phase II trial compared zalcitabine (0.03 mg/kg/day) in combination with zidovudine (720 mg/m2/day) and zidovudine monotherapy in 250 clinically stable, previously zidovudine-treated, human immunodeficiency virus-infected children. The combination was well-tolerated except for an increased incidence of
Effects of a combination of zidovudine, didanosine, and lamivudine on primary human immunodeficiency virus type 1 infection.: J Infect Dis. 1997 May;175(5):1051-5. Unique Identifier : AIDSLINE MED/97275171; Lafeuillade A; Poggi C; Tamalet C; Profizi N; Tourres C; Costes O; Department of Infectious Diseases, General Hospital, Toulon,; France.; A combination of zidovudine, didanosine, and lamivudine was used to treat 10 patients with primary human immunodeficiency virus type 1 (HIV-1) infection 5-28 days after the onset of symptoms. When therapy began, the mean plasma HIV-1 RNA level was 5.31 +/- 0.33 log10 copies/mL and the mean CD4 T cell count was 630 +/-
Evaluation of monoclonal antibodies to human immunodeficiency virus type 1 primary isolates by neutralization assays: performance criteria for selecting candidate antibodies for clinical trials. AIDS Clinical Trials Group Antibody Selection Working Group.: J Infect Dis. 1997 May;175(5):1056-62. Unique Identifier : AIDSLINE MED/97275172; D'Souza MP; Livnat D; Bradac JA; Bridges SH; Division of AIDS, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, Maryland; 20852, USA.; A collaborative study was organized to identify monoclonal antibodies (MAbs) that may be broadly and potently neutralizing for a panel of human immunodeficiency virus type 1 (HIV-1) low-passaged adult and pediatric primary isolates in peripheral blood mononuclear cells. Five laboratories evaluated a coded panel of sev
In vitro effect of alpha1-acid glycoprotein on the anti-human immunodeficiency virus (HIV) activity of the protease inhibitor CGP 61755: a comparative study with other relevant HIV protease inhibitors.: J Infect Dis. 1997 May;175(5):1063-70. Unique Identifier : AIDSLINE MED/97275173; Lazdins JK; Mestan J; Goutte G; Walker MR; Bold G; Capraro HG; Klimkait T; CIBA-GEIGY Ltd., Pharmaceutical Research, Basel, Switzerland.; Protein binding can impair the potency of human immunodeficiency virus (HIV) protease inhibitors . Therefore, the activity of a novel compound, CGP 61755, was studied in the absence or presence of alpha1-acid glycoprotein (alpha1AGP). In MT-2 cells, the activity loss
Detection of serum antibodies to a Kaposi's sarcoma-associated herpesvirus-specific peptide.: J Infect Dis. 1997 May;175(5):1071-9. Unique Identifier : AIDSLINE MED/97275174; Davis DA; Humphrey RW; Newcomb FM; O'Brien TR; Goedert JJ; Straus SE; Yarchoan R; HIV and AIDS Malignancy Branch and Viral Epidemiology Branch,; National Cancer Institute, National Institutes of Health,; Bethesda, Maryland 20892, USA.; Kaposi s sarcoma (KS)-associated herpesvirus/human herpesvirus type 8 (KSHV/HHV-8) may play an etiologic role in the pathogenesis of KS. In an attempt to assess KSHV/HHV-8 infection, an ELISA was developed using an 18-amino acid peptide from a putative minor capsid protein of KSHV/HHV-8 conjugated to bovine serum albu
Antiviral susceptibilities and analysis of UL97 and DNA polymerase sequences of clinical cytomegalovirus isolates from immunocompromised patients.: J Infect Dis. 1997 May;175(5):1087-92. Unique Identifier : AIDSLINE MED/97275176; Erice A; Gil-Roda C; Perez JL; Balfour HH Jr; Sannerud KJ; Hanson MN; Boivin G; Chou S; Department of Laboratory Medicine and Pathology, University of; Minnesota Medical School, Minneapolis 55455, USA.; Antiviral susceptibilities to ganciclovir, foscarnet, and cidofovir and sequencing of UL97 and DNA polymerase were done on 23 cytomegalovirus ( CMV ) isolates from 10 immunocompromised persons with end-organ CMV disease who wer
Antibody to chlamydial hsp60 predicts an increased risk for chlamydial pelvic inflammatory disease.: J Infect Dis. 1997 May;175(5):1153-8. Unique Identifier : AIDSLINE MED/97275185; Peeling RW; Kimani J; Plummer F; Maclean I; Cheang M; Bwayo J; Brunham RC; Department of Medical Microbiology, University of Manitoba,; Winnipeg, Canada.; To determine whether serum antibody to Chlamydia trachomatis antigens alters the risk of C. trachomatis pelvic inflammatory disease (PID), 280 female sex workers were prospectively evaluated over a 33-month period for incident C. trachomatis and Neisseria gonorrhoeae cervical infection and for clinical PID. At enrollm
Interleukin (IL)-2, IL-4, and tumor necrosis factor-alpha responses during Entamoeba histolytica liver abscess development in gerbils.: J Infect Dis. 1997 May;175(5):1176-83. Unique Identifier : AIDSLINE MED/97275188; Campbell D; Chadee K; Institute of Parasitology of McGill University,; Ste-Anne-de-Bellevue, Quebec, Canada.; To determine cytokine production patterns during hepatic amebiasis, gerbils were infected with Entamoeba histolytica in the liver. Then spleen and hepatic lymph node cell proliferation and interleukin (IL)-2 (a Th1 marker), IL-4 (a Th2 marker), and tumor necrosis factor-alpha (TNF-alpha) production in response to conc
Analysis of human herpesvirus type 8 infection in AIDS-related and AIDS-unrelated primary central nervous system lymphoma.: J Infect Dis. 1997 May;175(5):1193-7. Unique Identifier : AIDSLINE MED/97275190; Gaidano G; Capello D; Pastore C; Antinori A; Gloghini A; Carbone A; Larocca LM; Saglio G; Dipartimento di Scienze Biomediche e Oncologia Umana, Universita; di Torino, Turin, Italy.; Human herpesvirus type 8 (HHV-8) has been proposed as a pathogenetic factor for immunosuppression-associated primary central nervous system lymphoma (PCNSL). To verify this hypothesis, HHV-8 infection was investigated in 31 persons with PCNSL (16 AIDS-related, 15 AIDS-unrelated) and in 30 persons with systemic B cell
Exacerbations of clinical symptoms in human immunodeficiency virus type 1-infected patients with multicentric Castleman's disease are associated with a high increase in Kaposi's sarcoma herpesvirus DNA load in peripheral blood mononuclear cells.: J Infect Dis. 1997 May;175(5):1198-201. Unique Identifier : AIDSLINE MED/97275191; Grandadam M; Dupin N; Calvez V; Gorin I; Blum L; Kernbaum S; Sicard D; Buisson Y; Agut H; Escande JP; Huraux JM; Laboratoire de Virologie, CNRS EP 57, Hopital Tarnier, Paris,; France.; The epidemiologic link between multicentric Castleman s disease (MCD) and Kaposi s sarcoma (KS) and the high frequency of KS herpesvirus (KSHV) detection in both diseases raise the question of a role of this new virus in the pathogenesis of MCD. To explore this hypothesis, the KSHV DNA load was investigated in periphe
Monitoring responses to antiretroviral treatment in human immunodeficiency virus type 1 (HIV-1)-infected patients by serial lymph node aspiration.: J Infect Dis. 1997 May;175(5):1202-5. Unique Identifier : AIDSLINE MED/97275192; Burgisser P; Spertini F; Weyrich-Suter C; Pagani JL; Meylan PR; Division of Immunology and Allergy, Centre Hospitalier; Universitaire Vaudois, Lausanne, Switzerland.; Fine-needle aspiration was used to collect lymph node cells (LNC) from 9 antiretroviral-naive patients entering a double-blind single- or combined-drug study of zidovudine, zalcitabine, and saquinavir. LNC were obtained twice before and 1 and 6 months after initiation of treatment. The effect of antiretroviral treatme
Influence of other maternal variables on the relationship between maternal virus load and mother-to-infant transmission of human immunodeficiency virus type 1.: J Infect Dis. 1997 May;175(5):1206-10. Unique Identifier : AIDSLINE MED/97275193; Burns DN; Landesman S; Wright DJ; Waters D; Mitchell RM; Rubinstein A; Willoughby A; Goedert JJ; Pediatric, Adolescent, and Maternal AIDS Branch, National; Institute of Child Health and Human Development, National; Institutes of Health, Bethesda, MD 20892-7510, USA.; To assess the relationship between maternal human immunodeficiency virus (HIV) type 1 RNA level, other important covariates, and mother-to-infant (vertical) transmission of HIV-1, third trimester repository specimens from 160 HIV-1-seropositive women enrolled in the Mothers and Infants Cohort Study between 1986 and 19
Pentoxifylline improves cell-mediated immunity and reduces human immunodeficiency virus (HIV) plasma viremia in asymptomatic HIV-seropositive persons.: J Infect Dis. 1997 May;175(5):1210-5. Unique Identifier : AIDSLINE MED/97275194; Clerici M; Piconi S; Balotta C; Trabattoni D; Capetti A; Fusi ML; Ruzzante S; Longhi R; Colombo MC; Moroni M; Milazzo F; Cattedra di Immunologia, Universita degli Studi di Milano,; Milan, Italy.; The effects of pentoxifylline on immunologic and virologic parameters were evaluated in 10 human immunodeficiency virus-infected patients not receiving antiretroviral treatment. Patients were asymptomatic, had 300-500 CD4 cells/microL, and received pentoxifylline (1200 mg/day orally) for 4 months. Peripheral blood mon
A role for apoptosis in the pathogenesis of AIDS-related idiopathic esophageal ulcers.: J Infect Dis. 1997 May;175(5):1216-9. Unique Identifier : AIDSLINE MED/97275195; Houghton JM; Korah RM; Kim KH; Small MB; Department of Medicine (Division of Gastroenterology), University; of Medicine and Dentistry of New Jersey-New Jersey Medical; School, Newark 07103, USA.; Lack of understanding of the mechanism of tissue destruction associated with idiopathic esophageal ulcers (IEUs) poses a diagnostic and therapeutic dilemma for the clinician. The possible role of apoptosis in IEUs, as suggested by endoscopic and histologic observations, was investigated by examination of archival tiss
Herpes simplex virus type 1 induces apoptosis in peripheral blood T lymphocytes.: J Infect Dis. 1997 May;175(5):1220-4. Unique Identifier : AIDSLINE MED/97275196; Ito M; Watanabe M; Kamiya H; Sakurai M; Department of Pediatrics, Mie University School of Medicine,; Japan.; Apoptosis in peripheral blood T lymphocytes induced by herpes simplex virus type 1 (HSV-1) was investigated by use of DNA content analysis and the terminal deoxytransferase-mediated dUTP nick end-labeling method. The hypodiploid fraction in the cell cycle and DNA fragmentation were both increased in HSV-1-infected T l
Bordetella pertussis respiratory infection in children is associated with preferential activation of type 1 T helper cells.: J Infect Dis. 1997 May;175(5):1246-50. Unique Identifier : AIDSLINE MED/97275203; Ryan M; Murphy G; Gothefors L; Nilsson L; Storsaeter J; Mills KH; Department of Biology, Maynooth University, Ireland.; The mechanism of protective immunity against Bordetella pertussis generated following recovery from whooping cough in childhood has not yet been elucidated. Studies with a murine respiratory infection model have indicated that cellular immunity, mediated by Th1 cells, plays a role in the clearance of a primary infecti
Eosinophilia in patients infected with human immunodeficiency virus [letter]: J Infect Dis. 1997 May;175(5):1283. Unique Identifier : AIDSLINE MED/97275212; Colebunders R; Van Den Eynde C; Tolo A; Fleerackers Y; Vanham G; Kestens L; Vervoort T; Depraetere K
Neuroscience nurses' intentions to care for persons with HIV/AIDS.: J Neurosci Nurs. 1997 Feb;29(1):50-5. Unique Identifier : AIDSLINE MED/97220692; DiIorio C; Rollins School of Public Health, Emory University, Atlanta,; Georgia 30322, USA.; The purpose of this study, which was based on Ajzen s theory of planned behavior, was to determine the extent to which personal attitudes, subjective norms and perceptions of behavioral control influence the intentions of nurses to care for persons with HIV/AIDS. Questionnaires measuring the concepts of attitudes, sub
AIDS orphans in Louisiana in the year 2000: the potential economic impact on the foster care system.: J La State Med Soc. 1996 Sep;148(9):391-8. Unique Identifier : AIDSLINE MED/97294995; Parsons S; Merrick-Roddy P; Dept of Public Administration, Southern University, Baton Rouge,; La., USA.; This study estimates the number of AIDS orphans in Louisiana and projects the fiscal demand on the state s foster care system in the year 2000. The Michaels and Levine model is used to estimate the number of orphans, and state foster care data are used to project the placement cost of those AIDS orphans. Between 1992
Human immunodeficiency virus in otolaryngology [editorial]: J Laryngol Otol. 1997 Mar;111(3):209-11. Unique Identifier : AIDSLINE MED/97301033; Youngs R
The management of instability and incompleteness: clinical ethics and abstract expressionism.: J Med Philos. 1997 Feb;22(1):1-10. Unique Identifier : AIDSLINE MED/97249572; McCullough LB; Center for Medical Ethics and Health Policy, Baylor College of; Medicine, Houston, TX 77030, USA.; Central concepts and consensus views in clinical ethics are marked by instability. The papers in this number of the Journal take up two such central concepts, quality of life and moral status, and two such consensus views, that germ-line gene transfer should not be undertaken for the purposes of enhancement of human t
HIV infection, risk taking, and the duty to treat.: J Med Philos. 1997 Feb;22(1):55-74. Unique Identifier : AIDSLINE MED/97249576; Smolkin D; Department of Philosophy, Kansas State University, KS, USA.; The paper advances a consequence-based argument in support of the American Medical Association s policy that a physician may not ethically refuse to treat a person with HIV solely because the patient is seropositive. A limited number of alternative arguments, both in support of and in opposition to this policy are als
Suppression of herpes simplex virus type 1 (HSV-1)-induced pneumonia in mice by inhibition of inducible nitric oxide synthase (iNOS, NOS2).: J Exp Med. 1997 May 5;185(9):1533-40. Unique Identifier : AIDSLINE MED/97296306; Adler H; Beland JL; Del-Pan NC; Kobzik L; Brewer JP; Martin TR; Rimm IJ; Dana-Farber Cancer Institute, Department of Pediatrics,; Children's Hospital, Harvard Medical School, Boston,; Massachusetts 02115, USA.; Intranasal Herpes simplex virus type 1 (HSV-1) infection of mice caused pneumonia. Manifestations of the disease included: histological pneumonitis, pulmonary influx of lymphocytes, decreased pulmonary compliance, and decreased survival. Immunohistochemical staining demonstrated iNOS induction and the nitrotyrosine an
Chronic tumor necrosis factor alters T cell responses by attenuating T cell receptor signaling.: J Exp Med. 1997 May 5;185(9):1573-84. Unique Identifier : AIDSLINE MED/97296311; Cope AP; Liblau RS; Yang XD; Congia M; Laudanna C; Schreiber RD; Probert L; Kollias G; McDevitt HO; Department of Microbiology and Immunology, Stanford University; School of Medicine, California 94305, USA.; Repeated injections of adult mice with recombinant murine TNF prolong the survival of NZB/W F1 mice, and suppress type I insulin-dependent diabetes mellitus (IDDM) in non-obese diabetic (NOD) mice. To determine whether repeated TNF injections suppress T cell function in adult mice, we studied the responses of influenz
Minimal bystander activation of CD8 T cells during the virus-induced polyclonal T cell response.: J Exp Med. 1997 May 5;185(9):1629-39. Unique Identifier : AIDSLINE MED/97296316; Zarozinski CC; Welsh RM; Department of Pathology, University of Massachusetts Medical; Center, Worcester 01655, USA.; Acute infections with viruses such as lymphocytic choriomeningitis virus (LCMV) are associated with a massive polyclonal T cell response, but the specificities of only a small percentage of these activated T cells are known. To determine if bystander stimulation of T cells not specific to the virus plays a role in thi
Costimulation through B7-2 (CD86) is required for the induction of a lung mucosal T helper cell 2 (TH2) immune response and altered airway responsiveness.: J Exp Med. 1997 May 5;185(9):1671-9. Unique Identifier : AIDSLINE MED/97296320; Tsuyuki S; Tsuyuki J; Einsle K; Kopf M; Coyle AJ; R&D Dept. Kissei Pharmaceutical Co. Ltd., Matsumoto, Japan.; The recruitment of eosinophils into the airways after allergen exposure is dependent on interleukin (IL) 5 secreted from antigen-specific CD4+ T cells of the T helper cell (Th) 2 subset. However, while it is established that costimulation through CD28 is required for TCR-mediated activation and
CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro.: J Exp Med. 1997 May 5;185(9):1681-91. Unique Identifier : AIDSLINE MED/97296321; Wu L; Paxton WA; Kassam N; Ruffing N; Rottman JB; Sullivan N; Choe H; Sodroski J; Newman W; Koup RA; Mackay CR; LeukoSite, Inc., Cambridge, Massachusetts 02142, USA.; Chemokine receptors serve as coreceptors for HIV entry into CD4+ cells. Their expression is thought to determine the tropism of viral strains for different cell types, and also to influence susceptibility to infection and rates of disease progression. Of the chemokine receptors, CCR5 is the most important for viral tr
Infection control knowledge, practice, and attitudes of Mississippi dental hygienists.: J Dent Hyg. 1996 Jan-Feb;70(1):22-34. Unique Identifier : AIDSLINE MED/97304939; Daniel SJ; Silberman SL; Bryant EM; Meydrech EF; Department of Dental Hygiene, School of Health Related; Professions, University of Mississippi Medical Center, Jackson,; USA.; PURPOSE: The purpose of this study was to assess Mississippi dental hygienists knowledge and use of infection control techniques, attitudes pertaining to universal precautions and the risk of clinician/patient cross-infection, and attitudes toward treatment of patients with infectious diseases. METHODS: A 41-item que
HIV risk screening in the primary care setting. Assessment of physicians skills [see comments]: J Gen Intern Med. 1997 Feb;12(2):107-13. Unique Identifier : AIDSLINE MED/97203988; Wenrich MD; Curtis JR; Carline JD; Paauw DS; Ramsey PG; Department of Medicine, University of Washington, Seattle; 98195-6420, USA.; OBJECTIVE: To assess the content and extent of HIV risk assessment by primary care physicians across a diverse panel of patients with unidentified HIV risk behaviors. DESIGN: Standardized patient examination to assess primary care physicians skills at identifying and managing HIV infection and overall clinical skills
So much to do, so little time [editorial; comment]: J Gen Intern Med. 1997 Feb;12(2):135-6. Unique Identifier : AIDSLINE MED/97203995; Liss D
SLE nephropathy in a patient with HIV infection: case report and review of the literature.: J Rheumatol. 1996 Oct;23(10):1811-5. Unique Identifier : AIDSLINE MED/97050437; Kudva YC; Peterson LS; Holley KE; Wright AJ; Hunder GG; Mayo Clinic, Rochester, Minnesota 55905, USA.; We describe a 39-year-old bisexual man with clinical category B2 human immunodeficiency virus (HIV) infection who subsequently developed systemic lupus erythematosus (SLE). SLE was diagnosed on the basis of a clinical presentation of malar rash, polyarthritis, membranous glomerulonephritis, and characteristic serology
Treatment of HIV associated psoriatic arthritis with oral gold.: J Rheumatol. 1996 Oct;23(10):1818-20. Unique Identifier : AIDSLINE MED/97050439; Shapiro DL; Masci JR; Department of Medicine, Elmhurst Hospital Center, NY, USA.; We report a patient with human immunodeficiency virus (HIV) infection and disabling psoriatic arthritis who was treated with auranofin. Her skin lesions and arthritis resolved after auranofin treatment and she has remained free of opportunistic infections during 24 mo followup. Her CD4 count during oral gold therapy s
Herpes zoster encephalomyelitis associated with low dose methotrexate for rheumatoid arthritis.: J Rheumatol. 1997 Mar;24(3):589-91. Unique Identifier : AIDSLINE MED/97211704; Lyon CC; Thompson D; Wharfedale General Hospital, Otley, UK.; We describe herpes zoster encephalomyelitis occurring 9 days after the onset of cutaneous zoster in an elderly patient taking low dose weekly methotrexate without concomitant prednisolone.
Osteonecrosis and human immunodeficiency virus infection.: J Rheumatol. 1997 Mar;24(3):601-4. Unique Identifier : AIDSLINE MED/97211707; Rademaker J; Dobro JS; Solomon G; Department of Medicine, Beth Israel Medical Center, New York; City, NY 10003, USA.; We reviewed the clinical records of 6 patients with osteonecrosis and human immunodeficiency virus (HIV) infection. We conducted a literature search for the putative mechanism by which this association may occur. None of these 6 patients had other known conditions associated with a predisposition to osteonecrosis. Ava
Carbocyclic oxetanocins lacking the C-3' methylene.: J Med Chem. 1997 Apr 25;40(9):1401-6. Unique Identifier : AIDSLINE MED/97280711; Wu J; Schneller SW; Seley KL; Department of Chemistry, University of South Florida, Tampa; 33620, USA.; Using the observation that the side effects of aristeromycin (carbocyclic adenosine) were reduced by removing the methylene at the center in aristeromycin where phosphorylation occurs, derivatives of carbocyclic oxetanocin A (4a), oxetanocin G (4b), and 2-aminooxetanocin A (16) lacking the 3 -methylene have been prepa
Three-dimensional structure of an Fab-peptide complex: structural basis of HIV-1 protease inhibition by a monoclonal antibody.: J Mol Biol. 1997 Apr 18;267(5):1207-22. Unique Identifier : AIDSLINE GENBANK/U62633; Lescar J; Stouracova R; Riottot MM; Chitarra V; Brynda J; Fabry M; Horejsi M; Sedlacek J; Bentley GA; Unite d'Immunologie Structurale (URA 1961 CNRS), Departement; d'Immunologie, Institut Pasteur, Paris, France.; F11.2.32, a monoclonal antibody raised against HIV-1 protease (Kd = 5 nM), which inhibits proteolytic activity of the enzyme (K(inh) = 35(+/-3)nM), has been studied by crystallographic methods. The three-dimensional structure of the complex between the Fab fragment and a synthetic peptide, spanning residues 36 to 46 o
[Neurotropic viruses--classification, structure and characteristics]: Nippon Rinsho. 1997 Apr;55(4):777-82. Unique Identifier : AIDSLINE MED/97257323; Hotta H; Department of Microbiology, Kobe University School of Medicine.; Classification, structure and characteristics of neurotropic viruses are briefly summarized. Neurotropic viruses causing acute infection include Japanese, Venezuelan equine, and California encephalitis viruses, polio, coxsackie, echo, mumps, measles, influenza, and rabies viruses as well as members of the family Herpe
[Slow virus infection]: Nippon Rinsho. 1997 Apr;55(4):795-9. Unique Identifier : AIDSLINE MED/97257326; Yamanouchi K; Nippon Institute for Biological Science.; Subacute sclerosing panencephalitis (SSPE) and progressive multifocal leukoencephalopathy (PML) are the major slow virus infections of humans. SSPE is caused by mutant measles virus after long persistence in the brain. Its pathogenesis is discussed, based on accumulating data on molecular properties on measles virus p
[Genetic diagnosis of viral diseases in nervous system]: Nippon Rinsho. 1997 Apr;55(4):833-8. Unique Identifier : AIDSLINE MED/97257333; Nakamura S; Nakayama T; Third Department of Internal Medicine, Hiroshima University; School of Medicine.; The rapid diagnosis of viral infection in nervous system is necessary for the effective treatment, since they progress so rapidly. The identification of infected virus can be achieved by amplifying DNA or RNA in virus, using polymerase chain reaction (PCR). Herpes simplex encephalitis is the most common and fruitful t
[Herpes viruses--herpes simplex virus, varicella-zoster virus, EB virus, cytomegalovirus]: Nippon Rinsho. 1997 Apr;55(4):855-60. Unique Identifier : AIDSLINE MED/97257336; Fujiki N; Tashiro K; Department of Neurology, Obihiro Kosei Hospital.; Herpes simplex encephalitis is the commonest viral encephalitis among individuals, and the mortality has been markedly decreased by the use of vidarabine and acyclovir. Early diagnoses and immediate treatment are essential for favorable prognoses. Neuro-imagings, such as MRI and SPECT, and PCR technique for detection
[Pathogenesis of HIV-1-associated-neurologic diseases]: Nippon Rinsho. 1997 Apr;55(4):897-903. Unique Identifier : AIDSLINE MED/97257344; Yoshioka M; Itoyama Y; Neurology Service, Mizusawa City Hospital.; The neurologic disease most frequently seen during acquired immunodeficiency syndrome (AIDS) is AIDS dementia complex (ADC) or HIV encephalopathy, which is a direct consequence of HIV-1 infection of the central nervous system (CNS). A limited expression of HIV-1 in CNS and peripher
[HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP)]: Nippon Rinsho. 1997 Apr;55(4):926-33. Unique Identifier : AIDSLINE MED/97257349; Ijichi S; Ijichi N; Osame M; Nagahama Municipal Clinic, Faculty of Medicine, Kagoshima; University.; Human T lymphotropic virus type I(HTLV-I) is associated with the nonfatal neurologic disease, HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Many clinical signs of involvement outside the central nervous system (CNS) have been described in some patients with HAM/TSP and have triggered the discove
[Virus-related neurological disorders complicating in compromised hosts]: Nippon Rinsho. 1997 Apr;55(4):949-53. Unique Identifier : AIDSLINE MED/97257353; Kimura S; Dept. of Infection Control and Prevention, Faculty of Med., Univ.; of Tokyo.; Chance of opportunistic infections in hospitals is increasing year by year, because of the steady increase in the number of compromised hosts. Opportunistic infections in the nervous system include fungal, protozoal, bacterial and viral infections. Cytomegalovirus and herpes virus (HSV1 and HSV2) cause encephalitis, m
[Progress of the therapy for virus related neurological disorders]: Nippon Rinsho. 1997 Apr;55(4):959-66. Unique Identifier : AIDSLINE MED/97257355; Harukawa H; Yuasa T; Department of neurology, National center of Neurology and; Psychiatry, Kohnodai Hospital.; In this review of the therapy of infectious diseases and immune mediated nervous system diseases, we summarized the latest reports of antiviral drugs, immunosuppressants, immuno-modulatory and anti-inflammatory agents. Those include, acyclovir , vidarabine for herpes simplex ence
Antibodies to human herpesvirus 8 in women and infants born in Haiti and the USA [letter]: Lancet. 1997 May 10;349(9062):1368. Unique Identifier : AIDSLINE MED/97293811; Goedert JJ; Kedes DH; Ganem D
Never say never to a cure for HIV-1 infection [news]: Lancet. 1997 May 10;349(9062):1371. Unique Identifier : AIDSLINE MED/97293815; Morris K
Patterns of AIDS-related malignancies discussed at US meeting [news]: Lancet. 1997 May 10;349(9062):1372. Unique Identifier : AIDSLINE MED/97293816; Rowe PM
South Africa revolutionises HIV prevention and education strategies [news]: Lancet. 1997 May 10;349(9062):1377. Unique Identifier : AIDSLINE MED/97293817; Crowe S
HIV-prevention strategies.: Lancet. 1997 May 10;349(9062):1394-5. Unique Identifier : AIDSLINE MED/97293827; Gostin L
HIV-prevention strategies [letter]: Lancet. 1997 May 10;349(9062):1395. Unique Identifier : AIDSLINE MED/97293828; Fernando D
Home-use HIV test kits in Turkey [letter]: Lancet. 1997 May 10;349(9062):1401. Unique Identifier : AIDSLINE MED/97293840; Doganci L
Reproductive counselling for HIV-discordant couples [letter]: Lancet. 1997 May 10;349(9062):1401-2. Unique Identifier : AIDSLINE MED/97293841; Semprini AE; Fiore S; Pardi G
HTLV-I and blood safety: let the community decide [editorial; comment]: Med J Aust. 1997 May 5;166(9):454-5. Unique Identifier : AIDSLINE MED/97296867; Kaldor JM
Is screening of Australian blood donors for HTLV-I necessary? [see comments]: Med J Aust. 1997 May 5;166(9):478-81. Unique Identifier : AIDSLINE MED/97296873; Whyte GS; Australian Red Cross, Blood Bank of Victoria, Southbank.; rcbb@peg.apc.org; OBJECTIVE: To re-examine the 1992 decision by Australian Red Cross for its blood banks to screen blood donors for antibody to human T-cell lymphotropic virus type I (HTLV-I) by determining the risk of its transmission by blood transfusion. METHODS: Data on patterns of return behaviour by repeat blood donors in Victori
Challenge and response: HIV in Asia and the Pacific [letter]: Med J Aust. 1997 May 5;166(9):509-10. Unique Identifier : AIDSLINE MED/97296881; Crofts N; Deany P; Wodak AD
NYC reports sharp decline in AIDS deaths [news]: Minn Med. 1997 Mar;80(3):55. Unique Identifier : AIDSLINE MED/97245551
Safely needles reduce hospital workers' HIV risk [news]: Minn Med. 1997 Mar;80(3):55. Unique Identifier : AIDSLINE MED/97245552
[Effect of reverse transcriptase inhibitors on telomerase function in immortal murine fibroblasts]: Mol Biol (Mosk). 1997 Jan-Feb;31(1):130-6. Unique Identifier : AIDSLINE MED/97235280; Egorov EE; Chernov DN; Akimov SS; Bol'sheva NL; Kraevskii AA; Zelenin AV
[Theoretical study of the spatial structure of the Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr segment of the HIV gp120 protein, responsible for binding of the virus with the T-cell T4 receptor]: Mol Biol (Mosk). 1997 Jan-Feb;31(1):180-8. Unique Identifier : AIDSLINE MED/97235287; Andrianov AM; Akhrem AA
[Sequences of human chromosome 19 with partial homology to the human immunodeficiency virus type 1 genome]: Mol Biol (Mosk). 1997 Jan-Feb;31(1):38-44. Unique Identifier : AIDSLINE MED/97235268; Khaidarova NV; Nesmeianova KhP; Tarantul VZ
Detection of Pneumocystis carinii in induced sputa from immunocompromised patients using a repetitive DNA probe.: Mol Cell Probes. 1997 Feb;11(1):1-9. Unique Identifier : AIDSLINE MED/97231314; Graves DC; Chary-Reddy S; Becker-Hapak M; Department of Microbiology and Immunology, University of Oklahoma; Health Sciences Center, Oklahoma City 73190, USA.; A hybridization assay for the detection of Pneumocystis carinii was developed using a repetitive DNA fragment of P.c. hominis. The assay was specific as different micro-organisms typically found in the respiratory tract, normal human lung DNA (A 549 cell line) and normal rat lung DNA did not react with the repetitive
Successful quantification of cytomegalovirus DNA by competitive PCR and detection with capillary electrophoresis.: Mol Cell Probes. 1997 Feb;11(1):11-23. Unique Identifier : AIDSLINE MED/97231315; Poirier-Toulemonde AS; Imbert-Marcille BM; Ferre-Aubineau V; Besse B; Le Roux MG; Cantarovich D; Billaudel S; Laboratoire de Virologie, Institut de Biologie, CHRU, Nantes,; France.; Human cytomegalovirus (HCMV) is responsible for severe infections in immunocompromised patients. Viral load has recently been identified as one of the major risk factors for subsequent development of HCMV disease. In this context, we developed a protocol allowing rapid, sensitive a
Increased prevalence of oral Candida albicans serotype B in homosexual men: a comparative and longitudinal study in HIV-infected and HIV-negative patients.: Mycoses. 1996 Sep-Oct;39(9-10):353-6. Unique Identifier : AIDSLINE MED/97162683; Torssander J; Chryssanthou E; Petrini B; Department of Dermatology, Stockholm Soder Hospital, Sweden.; Several investigators have shown a comparatively high prevalence of Candida albicans serotype B among HIV-infected individuals. We serotyped oral C. albicans strains from 50 HIV-infected homosexual men, 39 HIV-seronegative homosexual men and 40 clinical oral isolates of a control group. The prevalence of serotype B wa
Tracheobronchial aspergillosis in a patient with AIDS treated with aerosolized amphotericin B combined with itraconazole.: Mycoses. 1996 Sep-Oct;39(9-10):371-4. Unique Identifier : AIDSLINE MED/97162687; Dal Conte I; Riva G; Obert R; Lucchini A; Bechis G; De Rosa G; Gioannini P; Department of Infectious Diseases, University of Turin, Amedeo di; Savoia Hospital, Italy.; The clinical features of a tracheobronchial infection due to Aspergillus flavus in an AIDS patient with a normal neutrophil count is described. Diagnosis was made by culture and microscopic examination of biopsies obtained from bronchial vegetations seen at bronchoscopy. Radiographic examination of the neck revealed t
Low-dose compared with standard-dose m-BACOD chemotherapy for non-Hodgkin's lymphoma associated with human immunodeficiency virus infection. National Institute of Allergy and Infectious Diseases AIDS Clinical Trials Group.: N Engl J Med. 1997 Jun 5;336(23):1641-8. Unique Identifier : AIDSLINE MED/97301686; Kaplan LD; Straus DJ; Testa MA; Von Roenn J; Dezube BJ; Cooley TP; Herndier B; Northfelt DW; Huang J; Tulpule A; Levine AM; Department of Medicine, San Francisco General Hospital, CA 94110,; USA.; BACKGROUND: Reduced doses of cytotoxic chemotherapy or standard-dose therapy plus a myeloid colony-stimulating factor decreases hematologic toxicity and its complications in patients with non-Hodgkin s lymphoma associated with infection with the human immunodeficiency virus (HIV).
[Little HIV risk behavior in drug users during detention in Dutch penitentiaries]: Ned Tijdschr Geneeskd. 1997 Mar 1;141(9):429-33. Unique Identifier : AIDSLINE MED/97248901; van Haastrecht HJ; Bax JS; van den Hoek JA; Gemeentelijke Geneeskundige en Gezondheidsdienst. Divisie; Volksgezondheid en Milieu, Amsterdam.; OBJECTIVE: To assess levels of HIV risk behaviour in injecting drug users during and immediately following prison terms in the Netherlands . DESIGN: Descriptive. SETTING: Municipal Health Service, Amsterdam, the Netherlands. METHODS: Injecting drug users taking part in a follow
High-signal lesions in the midbrain on T1-weighted MRI in an HIV-infected patient.: Neuroradiology. 1997 Feb;39(2):136-8. Unique Identifier : AIDSLINE MED/97197680; Luttmann S; Husstedt IW; Schuierer G; Kuhlenbaumer G; Stodieck S; Riedasch M; Reichelt D; Zidek W; Department of Neurology, University of Munster, Germany.; In addition to opportunistic infections, neoplasms or cerebrovascular complications, metabolic encephalopathies are a classical cause of diffuse brain dysfunction in HIV infection and are frequent in the terminal stage. We report an HIV-infected patient with symmetrical, focally increased signal in the midbrain on pro
Progressive multifocal leukoencephalopathy in an HIV-infected child.: Neuroradiology. 1997 Feb;39(2):142-4. Unique Identifier : AIDSLINE MED/97197682; Morriss MC; Rutstein RM; Rudy B; Desrochers C; Hunter JV; Zimmerman RA; Department of Radiology, The Children's Hospital of Philadelphia,; PA 19104, USA.; A child with perinatally acquired HIV infection presented with acute neurologic deterioration. A cerebellar white matter lesion seen on CT and MRI later proved to be progressive multifocal leukoencephalopathy (PML) by histology. Although a recognized disease of HIV-infected adults, PML is certain to be seen with more
FDA clears new treatment for invasive aspergillosis.: Oncol Nurs Forum. 1997 Jan-Feb;24(1):107. Unique Identifier : AIDSLINE MED/97160412
Life stress and risk of precancerous cervical lesions: a pretest directed by the life stress model.: Oncol Nurs Forum. 1997 Jan-Feb;24(1):63-70. Unique Identifier : AIDSLINE MED/97160408; Lovejoy NC; Roche N; McLean D; University of Massachussetts, Boston.; PURPOSE/OBJECTIVES: To present the results of a pilot study to pretest instruments designed to measure selected variables named in the Life Stress Model, a model of health outcomes. Additional aims were to determine the effect of completing personal risk assessments for precancerous squamous-cell intraepithelial lesio
Haemophilia.: Postgrad Med J. 1997 Apr;73(858):201-6. Unique Identifier : AIDSLINE MED/97301101; Cahill MR; Colvin BT; Haemophilia Comprehensive Care Centre, Royal London Hospital,; Whitechapel, UK.; Although the nature of haemophilia has been understood for thousands of years, knowledge of its molecular genetics is recent. These X-linked bleeding disorders have diverse underlying DNA defects and, in 1992, DNA inversion within the X chromosome was found to explain half of the most serious cases of haemophilia A. T
Haemopoietic growth factors.: Postgrad Med J. 1997 Apr;73(858):215-21. Unique Identifier : AIDSLINE MED/97301103; Ketley NJ; Newland AC; Department of Haematology, London Hospital Medical College, UK.; Haemopoietic growth factors are involved in the production of the various blood cells from progenitors in the bone marrow, making them useful in a range of clinical situations. The genes for several of them have been cloned and their production engineered by recombinant technology, making them widely available. Myeloi
[Viral load]: Presse Med. 1997 Apr 12;26(12):560-2. Unique Identifier : AIDSLINE MED/97305167; Sicard D
Probing the structure of the HIV-1 Rev trans-activator protein by functional analysis.: Protein Eng. 1997 Feb;10(2):103-7. Unique Identifier : AIDSLINE MED/97245050; Thomas SL; Hauber J; Casari G; SANDOZ Research Insitute, Department of Immunodermatology,; Vienna, Austria.; Human immunodeficiency virus type 1 (HIV-1) encodes a trans-acting regulatory protein, termed Rev, which is critically required for virus replication. Rev is a sequence-specific RNA binding protein which mediates the nuclear export of unspliced and incompletely spliced viral mRNAs encoding the viral structural protein
Molecular uncoupling of C-C chemokine receptor 5-induced chemotaxis and signal transduction from HIV-1 coreceptor activity.: Proc Natl Acad Sci U S A. 1997 May 13;94(10):5061-6. Unique Identifier : AIDSLINE MED/97289719; Gosling J; Monteclaro FS; Atchison RE; Arai H; Tsou CL; Goldsmith MA; Charo IF; Gladstone Institute of Cardiovascular Disease, University of; California, San Francisco, CA 94110, USA.; The C-C chemokine receptor 5 (CCR5) plays a crucial role in facilitating the entry of macrophage-tropic strains of the HIV-1 into cells, but the mechanism of this phenomenon is completely unknown. To explore the role of CCR5-derived signal transduction in viral entry, we introduced mutations into two cytoplasmic domai
A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity.: Proc Natl Acad Sci U S A. 1997 May 13;94(10):5267-72. Unique Identifier : AIDSLINE MED/97289755; Yamamoto S; Kiyono H; Yamamoto M; Imaoka K; Fujihashi K; Van Ginkel FW; Noda M; Takeda Y; McGhee JR; Department of Microbiology, The Immunobiology Vaccine Center,; University of Alabama, Medical Center, Birmingham, AL 35294-2170,; USA.; We have characterized a nontoxic mutant of cholera toxin (CT) as a mucosal adjuvant in mice. The mutant CT was made by substitution of serine with phenylalanine at position 61 of the A subunit (S61F), which resulted in loss of ADP ribosyltransferase activity and toxicity. Mice were intranasally immunized with ovalbumi
Molecular cloning, sequence, expression, and processing of the interleukin 16 precursor.: Proc Natl Acad Sci U S A. 1997 May 13;94(10):5273-7. Unique Identifier : AIDSLINE GENBANK/U82972; Baier M; Bannert N; Werner A; Lang K; Kurth R; Paul-Ehrlich-Institut, Paul-Ehrlich-Strasse 51-59, 63225 Langen,; Germany. M.Baier@em.uni-frankfurt.de; Interleukin 16 (IL-16) has been shown to function as chemoattractant factor, as a modulator of T-cell activation, and as an inhibitor of immunodeficiency virus replication. The recent identification of inconsistencies in published IL-16 cDNA nucleotide sequences led to the proposal that IL-16 is synthesized in the for
Cognitive and emotional deficits in early stages of HIV infection: an event-related potentials study.: Prog Neuropsychopharmacol Biol Psychiatry. 1996 Nov;20(8):1303-14. Unique Identifier : AIDSLINE MED/97158059; Bungener C; Le Houezec JL; Pierson A; Jouvent R; CNRS URA 1957, Hopital de la Salpetriere, Paris, France.; 1. In order to inventory different Event-Related Potentials (ERP) modifications in HIV-infection the authors have evaluated 23 HIV-positive subjects and 12 HIV-negative subjects. ERP were recorded during an auditory oddball task. 2. Electrophysiological results showed that the latency of the N100 component of the ERP
[Campylobacter jejuni septicemia with cutaneous sites in a patient with human immunodeficiency virus infection (letter)]: Rev Med Interne. 1997;18(3):257-8. Unique Identifier : AIDSLINE MED/97305316; Malbec D; Poiraud S; Dallot A; Boudon P
[Ocular manifestations of AIDS. Personal observations and literature review]: Rev Med Liege. 1997 Feb;52(2):98-100. Unique Identifier : AIDSLINE MED/97245614; Massoud H; Dumont P; Service d'Ophtalmologie, CHU de Liege.
Quality of life in HIV infection.: Scand J Gastroenterol Suppl. 1996;221:30-2. Unique Identifier : AIDSLINE MED/97264590; O'Keefe EA; Wood R; Somerset Hospital HIV Clinic, University of Cape Town,; Greenpoint, South Africa.; HIV infection gives rise to incurable, debilitating disease in young persons and treatments capable of prolonging survival are often associated with toxicity. Quality of Life (QOL) assessment is therefore important in the evaluation of clinical interventions in HIV-infected patients. It also has a role in determining
Ethics of AZT studies in poorer countries attacked [news]: Science. 1997 May 16;276(5315):1022. Unique Identifier : AIDSLINE MED/97311239; Cohen J
Symptomatic HIV infection in infancy--clinical and laboratory markers of infection.: S Afr Med J. 1997 Feb;87(2):158-62. Unique Identifier : AIDSLINE MED/97261267; Meyer MP; Latief Z; Haworth C; Salie S; van Dyk A; Department of Paediatrics, Groote Schuur Hospital, Cape Town.; OBJECTIVE: To investigate the usefulness of immunological tests in the diagnosis of HIV infection in young symptomatic children (
HIV confirmation and counselling in the insurance industry [letter]: S Afr Med J. 1997 Feb;87(2):173-4. Unique Identifier : AIDSLINE MED/97261271; Barker EM
HIV confirmation and counselling in the insurance industry [letter]: S Afr Med J. 1997 Feb;87(2):174. Unique Identifier : AIDSLINE MED/97261272; Lockyer IK
Nebulizer therapy. Guidelines. British Thoracic Society Nebulizer Project Group.: Thorax. 1997 Apr;52 Suppl 2:S4-24. Unique Identifier : AIDSLINE MED/97300827
Nebulisers for patients with HIV infection and AIDS.: Thorax. 1997 Apr;52 Suppl 2:S60-3. Unique Identifier : AIDSLINE MED/97300834; Miller RF; O'Doherty MJ; Division of Pathology and Infectius Diseases, University College; London Medical School, Camden and Islington Community Health; Services NHS Trust, Middlesex Hospital, UK.
Elevated intracellular glutathione levels in CD4+ T cells of BB rats.: Transplant Proc. 1997 May;29(3):1679-80. Unique Identifier : AIDSLINE MED/97287138; Groen H; Pater JM; Nieuwenhuis P; Rozing J; Department of Histology & Cell Biology, University of Groningen,; Oostersingel, The Netherlands.
Induction of insulin-dependent diabetes mellitus in PVG.RT1u rats.: Transplant Proc. 1997 May;29(3):1684-5. Unique Identifier : AIDSLINE MED/97287140; Whalen BJ; Doukas J; Mordes JP; Rossini AA; Greiner DL; Diabetes Division, University of Massachusetts Medical School,; Worcester 01605, USA.
Screening of HIV-1 Env glycoproteins for the ability to raise neutralizing antibody using DNA immunization and recombinant vaccinia virus boosting.: Virology. 1997 Apr 14;230(2):265-74. Unique Identifier : AIDSLINE MED/97288304; Richmond JF; Mustafa F; Lu S; Santoro JC; Weng J; O'Connell M; Fenyo EM; Hurwitz JL; Montefiori DC; Robinson HL; Department of Pathology, University of Massachusetts Medical; School, Worcester 01655, USA.; HIV-1 envelopes from two series of primary isolates (from Swedish patients 5 and 6), from JR-FL and BaL (prototypic monocyte/macrophage tropic viruses) and from HXB-2 (a prototypic T-cell-line-adapted virus), have been screened for their ability to elicit neutralizing antibody to HIV-1. Rabbits were primed by gene gun
Human immunodeficiency virus type 1 (HIV-1) infection of herpesvirus saimiri-immortalized human CD4-positive T lymphoblastoid cells: evidence of enhanced HIV-1 replication and cytopathic effects caused by endogenous interferon-gamma.: Virology. 1997 Apr 28;231(1):1-9. Unique Identifier : AIDSLINE MED/97288318; Saha K; Caruso M; Volsky DJ; Molecular Virology Laboratory, St. Luke's-Roosevelt Hospital; Center, College of Physicians and Surgeons, Columbia University,; New York, New York 10019, USA.; Herpesvirus saimiri (HVS) is a nonhuman primate gamma herpesvirus which can immortalize human T lymphocytes similar to Epstein-Barr virus immortalization of B cells. The HVS-immortalized T cell lines can be cloned and they remain functional, including susceptibility of CD4 expressing T cells to infection with human im
Enhancement of HIV-1-induced syncytium formation in T cells by the tyrosyl kinase p56lck.: Virology. 1997 Apr 28;231(1):10-9. Unique Identifier : AIDSLINE MED/97288319; Briand G; Barbeau B; Corbeil J; Tremblay M; Centre de Recherche en Infectiologie, Centre Hospitalier; Universitaire de Quebec, Ste-Foy, Canada.; The CD4 glycoprotein is the primary cellular receptor for human immunodeficiency virus type 1 (HIV-1) and has also been reported to be physically associated with p56lck, a tyrosyl protein kinase p56lck is a member of the src family of nonreceptor protein-tyrosine kinases and is expressed predominantly in T lymphocytes
Role of the amino-terminal extracellular domain of CXCR-4 in human immunodeficiency virus type 1 entry.: Virology. 1997 Apr 28;231(1):105-11. Unique Identifier : AIDSLINE MED/97288330; Picard L; Wilkinson DA; McKnight A; Gray PW; Hoxie JA; Clapham PR; Weiss RA; Chester Beatly Laboratories, Institute of Cancer Research,; London, United Kingdom. laurent@icr.ac.uk; We have studied the role of the N-terminal extracellular domain of the human immunodeficiency virus type 1 (HIV-1) coreceptor, CXCR-4, in the entry and fusion of syncytium-inducing strains of HIV-1. Progressive deletions were introduced in the N-terminal extracellular domain of CXCR-4 and the effect on infection by di
In vitro selection for different mutational patterns in the HIV-1 reverse transcriptase using high and low selective pressure of the nonnucleoside reverse transcriptase inhibitor HBY 097.: Virology. 1997 Apr 28;231(1):112-8. Unique Identifier : AIDSLINE MED/97288331; Kleim JP; Winkler I; Rosner M; Kirsch R; Rubsamen-Waigmann H; Paessens A; Riess G; Hoechst AG, Frankfurt, Germany.; In vitro resistance of HIV-1 against high levels of HBY 097 ((S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3, 4-dihydro-quinoxaline-2(1H)-thione) and other quinoxaline nonnucleoside reverse transcriptase inhibitors (NNRTIs) is characterized by a specific amino acid substitution in the reverse transcriptase (
CD4-independent infection by HIV-2 (ROD/B): use of the 7-transmembrane receptors CXCR-4, CCR-3, and V28 for entry.: Virology. 1997 Apr 28;231(1):130-4. Unique Identifier : AIDSLINE MED/97288333; Reeves JD; McKnight A; Potempa S; Simmons G; Gray PW; Power CA; Wells T; Weiss RA; Talbot SJ; Institute of Cancer Research, Chester Beatty Laboratories,; London, United Kingdom.; We have assayed a variety of 7tm chemokine receptors (CCR-2b, CCR-3, CCR-4, CCR-5, CXCR-1, CXCR-4) and two orphan 7tm receptors (V28 and EBI.1) for their ability to allow infection of CD4-negative feline kidney CCC cells by the HIV-2 strains ROD/A and ROD/B. We found that ROD/B was able to use CXCR-4 transiently expre
Repression of bax gene expression by the HTLV-1 Tax protein: implications for suppression of apoptosis in virally infected cells.: Virology. 1997 Apr 28;231(1):135-40. Unique Identifier : AIDSLINE MED/97288334; Brauweiler A; Garrus JE; Reed JC; Nyborg JK; Department of Biochemistry and Molecular Biology, Colorado State; University, Fort Collins 80523-1870, USA.; The human T-cell leukemia virus-encoded oncoprotein Tax is a potent deregulator of cellular gene expression. Here we report that Tax represses transcription of the human bax gene, a gene whose protein product accelerates apoptosis. This repression is mediated through a 27-bp sequence in the bax promoter that contains
Immunosenescence in HIV pathogenesis.: Virology. 1997 Apr 28;231(1):148-54. Unique Identifier : AIDSLINE MED/97288336; Pommier JP; Gauthier L; Livartowski J; Galanaud P; Boue F; Dulioust A; Marce D; Ducray C; Sabatier L; Lebeau J; Boussin FD; Laboratoire de Radiobiologie et Oncologie, DRR, DSV, CEA,; Fontenay-aux- Roses, France.; Telomeres are complex protein-DNA structures located at the ends of eukaryotic chromosomes. In a normal cell, telomere DNA shortens with cell divisions. Such a telomere loss may act as a mitotic clock to eventually signal cell cycling exit and cellular senescence. In a transversal study, we found a marked decrease in
Sequence analysis of HIV-1 group O from Norwegian patients infected in the 1960s.: Virology. 1997 Apr 28;231(1):43-7. Unique Identifier : AIDSLINE GENBANK/L20571; Jonassen TO; Stene-Johansen K; Berg ES; Hungnes O; Lindboe CF; Froland SS; Grinde B; Department of Virology, National Institute of Public Health,; Oslo, Norway.; Three Norwegians, a couple and their daughter, died from AIDS in 1976 after up to 10 years of clinical manifestations of HIV infection (Lindboe et al., 1986, Acta Pathol. Microbiol, Immunol. Scand. 94, 117-123; Froland et al., 1988, Lancet i, 1344-1345). We here demonstrate the presence of HIV DNA in autopsy materials
Recombinant HIV envelope expressed in an alpha-glucosidase I-deficient CHO cell line and its parental cell line in the presence of 1-deoxynojirimycin is functional.: Virology. 1997 Apr 28;231(1):89-95. Unique Identifier : AIDSLINE MED/97288328; Fenouillet E; Papandreou MJ; Jones IM; CNRS UMR 6560, Faculte de Medecine Nord, Marseillo, France.; fenouillet.e@jean-roche.univ-mrs.fr; alpha-Glucosidase inhibitors-e.g., 1-deoxynojirimycin (DNM)-interfere with HIV infectivity in CD4+ cell cultures but have proven unsuccessful in clinical trials. In vitro, several HIV Env properties, including the cleavage of the Env precursor gp 160, the immunoreactivity of the third variable domain (V3) of Env, the
The tax gene sequences form two divergent monophyletic lineages corresponding to types I and II of simian and human T-cell leukemia/lymphotropic viruses.: Virology. 1997 Apr 28;231(1):96-104. Unique Identifier : AIDSLINE GENBANK/U59144; Giri A; Slattery JP; Heneine W; Gessain A; Rivadeneira E; Desrosiers RC; Rosen L; Anthony R; Pamungkas J; Iskandriati D; Richards AL; Herve V; McClure H; O'Brien SJ; Franchini G; Basic Research Laboratory, National Cancer Institute, Bethesda,; Maryland 20892, USA.; Evolutionary associations of human and simian T-cell leukemia/lymphotropic viruses I and II (HTLV-I/II and STLV-I/II) are inferred from phylogenetic analysis of tax gene sequences. Samples studied consisted of a geographically diverse assemblage of viral strains obtained from 10 human subjects and 20 individuals repre
[Statistics--lying, but properly]: Wien Med Wochenschr. 1997;147(3):72-4. Unique Identifier : AIDSLINE MED/97241232; Bias R
Gastrointestinal lymphomas in patients with AIDS.: Z Gastroenterol. 1997 Mar;35(3):179-85. Unique Identifier : AIDSLINE MED/97260873; Powitz F; Bogner JR; Sandor P; Zietz C; Goebel FD; Zoller WG; Med. Poliklinik der Universitat Munchen.; Non-Hodgkin-lymphoma (NHL)-most frequently high grade B-cell lymphoma-occurs in 5-10% of individuals with HIV-infection. The gastrointestinal tract (GIT) is the most frequent extranodal site of the disease. The optimal therapy for HIV-related lymphoma remains a matter of controversy. In a retrospective analysis we fou
The Third International Feline Retrovirus Research Symposium.: Vaccine. 1997 Feb;15(2):107-10. Unique Identifier : AIDSLINE MED/97314956; Burkhard MJ; Hoover EA; Department of Pathology, Colorado State University, Fort Collins; 80523, USA.
Microencephaly in children congenitally infected with human immunodeficiency virus--a gross-anatomical morphometric study.: Acta Neuropathol (Berl). 1997 Feb;93(2):136-45. Unique Identifier : AIDSLINE MED/97191502; Kozlowski PB; Brudkowska J; Kraszpulski M; Sersen EA; Wrzolek MA; Anzil AP; Rao C; Wisniewski HM; New York State Institute for Basic Research in Developmental; Disabilities, Staten Island 10314, USA.; A quantitative technique involving serial sectioning and semiautomatic morphometric analysis was used to assess the severity of the reduction in size of the major brain structures in cerebral hemispheres of children congenitally infected with HIV-1. Cerebral hemispheres from 12 children (18-48 months of age) who died
Cerebral white matter damage in HIV infection demonstrated using beta-amyloid precursor protein immunoreactivity.: Acta Neuropathol (Berl). 1997 Feb;93(2):184-9. Unique Identifier : AIDSLINE MED/97191509; Raja F; Sherriff FE; Morris CS; Bridges LR; Esiri MM; Department of Neurology, Radcliffe Infirmary, Oxford, UK.; We have examined brain sections from 55 autopsy cases of AIDS for the prevalence and severity of axonal damage, assessed using beta-amyloid precursor protein (beta APP) immunoreactivity as a marker of such damage. The cases were subdivided into cases with HIV encephalitis with multinucleated giant cells (MGC), cases w
A nasal septum perforation caused by a Varicella zoster infection in an AIDS patient.: Acta Otorhinolaryngol Belg. 1997;51(1):49-50. Unique Identifier : AIDSLINE MED/97259364; Colebunders R; De Roo A; Benimadho S; Mestdagh F; Van Damme P; Institute of Tropical Medicine, University Hospital, University; of Antwerp, Wilrijk, Belgium.; A nasal septum perforation caused by a Varicella Zoster Infection in an AIDS patient. A patient with an acquired immune deficiency syndrome is described who developed a nasal septum perforation. This perforation was probably caused by frequently scratching chronic zoster lesions inside the nose.
Perspectives in interferon and cytokine research, Memorial day in honor of Professor Giovanni Battista Rossi.: J Biol Regul Homeost Agents. 1996 Jan-Mar;10(1):1-7. Unique Identifier : AIDSLINE MED/97202247; Affabris E; Battistini A; Belardelli F; Coccia EM; Romeo G; Dept. of Biology, Universita di Roma 3, Italy.
Investigation of the potential role of membrane CD38 in protection against cell death induced by HIV-1.: J Biol Regul Homeost Agents. 1996 Jan-Mar;10(1):13-8. Unique Identifier : AIDSLINE MED/97202249; Savarino A; Pugliese A; Martini C; Pich PG; Pescarmona GP; Malavasi F; Department of Medical and Surgical Sciences, University of; Torino, Italy.; The aim of the present study was to assess the possibility that mCD38, a bifunctional ectoenzyme with NAD+ hydrolase and ADP ribose cyclase activities, exerts a protective role in the development of acute, non-syncytial cell death from HIV-1. This hypothesis was tested in a panel of human T-cell lines with defined mem
Effects of serotonin and melanin on in vitro HIV-1 infection.: J Biol Regul Homeost Agents. 1996 Jan-Mar;10(1):19-24. Unique Identifier : AIDSLINE MED/97202250; Sidibe S; Saal F; Rhodes-Feuillette A; Lagaye S; Pelicano L; Canivet M; Peries J; Dianoux L; CNRS/Institut d' Hematologie, Hopital Saint-Louis, Paris,; France.; In this article, we describe the effect of indoleamines: serotonin (5-HT) and synthetic soluble melanin, on the multiplication of HIV-1 in T4 lymphocytic cell lines. The results show that viral production is increased when infected CEM-11 cells are incubated with 5-HT (10(-7) M and 10(-8) M) for 72 hours, whereas at h
Mannoproteins from Candida albicans elicit a Th-type-1 cytokine profile in human Candida specific long-term T cell cultures.: J Biol Regul Homeost Agents. 1996 Jan-Mar;10(1):8-12. Unique Identifier : AIDSLINE MED/97202248; La Sala A; Urbani F; Torosantucci A; Cassone A; Ausiello CM; Department of Bacteriology, Istituto Superiore di Sanita, Roma,; Italy.; Since T lymphocytes are active producers of regulatory cytokines, long-term T cell cultures (LTTC) specific for a major mannoproteic antigen (MP) of Candida albicans from peripheral blood mononuclear cells (PBMC) of healthy donors were generated and their cytokine profile studied. LTTC consisted of an expanded CD3CD4
Absence of human herpesvirus 8 genomes in coronary atherosclerosis in immunocompetent patients.: Am J Cardiol. 1997 May 1;79(9):1245-7. Unique Identifier : AIDSLINE MED/97307553; Ye D; Nichols TC; Dehmer GJ; Tate DA; Wehbie RS; Quinlivan EB; Department of Medicine, Lineberger Comprehensive Cancer Center,; University of North Carolina, Chapel Hill, USA.; Human herpevirus 8 (HHV8) has been localized to the endothelial and spindle cells of KS, suggesting a role for HHV8 in atherosclerosis. None of the 38 coronary atherectomy specimens contained HHV8 with both sensitive nested PCR assays, making it unlikely that persistent viral infection with HHV8 plays a role in corona
A method for combined immunoaffinity purification and assay of HIV-1 reverse transcriptase activity useful for crude samples.: Anal Biochem. 1996 Mar 15;235(2):141-52. Unique Identifier : AIDSLINE MED/96430194; Lennerstrand J; Rytting AS; Orvell C; Gronowitz JS; Kallander CF; The Research Unit of Replication Enzymology, Department of; Medical Genetics, Uppsala University, Bromma, Sweden.; Detection of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) activity in crude specimens was greatly enhanced using a novel capture RT assay. Eighteen different monoclonal antibodies (Mabs) raised against purified HIV-1 RT were tested for their ability to bind to HIV-1 RT without affecting its a
A mutation in human immunodeficiency virus type 1 protease at position 88, located outside the active site, confers resistance to the hydroxyethylurea inhibitor SC-55389A.: Antimicrob Agents Chemother. 1997 Mar;41(3):515-22. Unique Identifier : AIDSLINE MED/97209043; Smidt ML; Potts KE; Tucker SP; Blystone L; Stiebel TR Jr; Stallings WC; McDonald JJ; Pillay D; Richman DD; Bryant ML; G.D. Searle, St. Louis, Missouri, USA. mlsmid@ccmail.monsanto.com; The hydroxyethylurea human immunodeficiency virus type 1 (HIV-1) protease inhibitors SC-55389A and SC-52151 were used to select drug-resistant variants in vitro. One clinical HIV-1 strain (89-959) and one laboratory HIV-1 strain (LAI) were passaged in peripheral blo
In vitro activities of voriconazole (UK-109,496) against fluconazole-susceptible and -resistant Candida albicans isolates from oral cavities of patients with human immunodeficiency virus infection.: Antimicrob Agents Chemother. 1997 Mar;41(3):575-7. Unique Identifier : AIDSLINE MED/97209053; Ruhnke M; Schmidt-Westhausen A; Trautmann M; Abteilung Innere Medizin und Poliklinik, Virchow-Klinikum der; Humboldt-Universitat, Berlin, Germany. mruhnke@ukrv.de; The susceptibility of Candida albicans to a new antifungal triazole, voriconazole (UK-109,496), was investigated in 105 isolates obtained from the oral cavities of patients with human immunodeficiency virus (HIV) infection to study this drug s activity against fluconazole-susceptible and -resistant isolates. MICs were
Activities of various compounds against murine and primate polyomaviruses.: Antimicrob Agents Chemother. 1997 Mar;41(3):587-93. Unique Identifier : AIDSLINE MED/97209056; Andrei G; Snoeck R; Vandeputte M; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.; Polyomavirus infections in humans are due to BK virus (BKV) and JC virus (JCV). Diseases associated with human polyomaviruses occur mostly in immunocompromised adults, e.g., progressive multifocal leukoencephalopathy (PML), caused by JCV, in AIDS patients and hemorrhagic cystitis and uretral stenosis, caused by BKV, i
Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newborn NMRI mice.: Antimicrob Agents Chemother. 1997 Mar;41(3):611-6. Unique Identifier : AIDSLINE MED/97209060; Balzarini J; Vahlenkamp T; Egberink H; Hartmann K; Witvrouw M; Pannecouque C; Casara P; Nave JF; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.; From a side-by-side comparative study, the acyclic nucleoside phosphonates (R)-9-(2-phosphonylmethoxypropyl)adenine [(R)-PMPA] and 9-(2-methylidene-3-phosphonomethoxypropyl)guanine (MDL 74,968) proved more selective in their inhibitory effect on human immunodeficiency virus types 1 and 2, feline immunodeficiency virus
Antifungal drug susceptibilities of oral Candida dubliniensis isolates from human immunodeficiency virus (HIV)-infected and non-HIV-infected subjects and generation of stable fluconazole-resistant derivatives in vitro.: Antimicrob Agents Chemother. 1997 Mar;41(3):617-23. Unique Identifier : AIDSLINE MED/97209061; Moran GP; Sullivan DJ; Henman MC; McCreary CE; Harrington BJ; Shanley DB; Coleman DC; Department of Oral Medicine and Pathology, School of Dental; Science, Trinity College, University of Dublin, Republic of; Ireland.; Candida dubliniensis is a recently described species of Candida associated with oral candidiasis in human immunodeficiency virus (HIV)-infected individuals. Nineteen oral isolates of C. dubliniensis recovered from 10 HIV-positive and 4 HIV-negative individuals and one vaginal isolate from an additional HIV-negative su
Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir.: Antimicrob Agents Chemother. 1997 Mar;41(3):654-60. Unique Identifier : AIDSLINE MED/97209067; Kempf DJ; Marsh KC; Kumar G; Rodrigues AD; Denissen JF; McDonald E; Kukulka MJ; Hsu A; Granneman GR; Baroldi PA; Sun E; Pizzuti D; Plattner JJ; Norbeck DW; Leonard JM; Department of Infectious Diseases Research, Abbott Laboratories,; Illinois 60064, USA. Dale.J.Kempf@abbott.com; Coadministration with the human immunodeficiency virus (HIV) protease inhibitor ritonavir was investigated as a method for enhancing the levels of other peptidomimetic HIV protease inhibitors in pla
Potency comparison of peptidomimetic inhibitors against HIV-1 and HIV-2 proteinases: design of equipotent lead compounds.: Arch Biochem Biophys. 1997 May 1;341(1):62-9. Unique Identifier : AIDSLINE MED/97288375; Weber J; Majer P; Litera J; Urban J; Soucek M; Vondrasek J; Konvalinka J; Novek P; Sedlacek J; Strop P; Krausslich HG; Pichova I; Department of Biochemistry, Institute of Organic Chemistry and; Biochemistry, Academy of Sciences of the Czech Republic, Prague; 6, Czech Republic.; HIV-1 and HIV-2 proteinases (PR) are responsible for the processing of viral polyproteins, a step that is crucial for the formation of infectious virus particles. PR represents one of the most important targets for antiviral chemotherapy. Inhibitors of HIV-1 PR usually exhibit a 10- to 100-fold weaker affinity for HIV
Retrograde transport of acidic fibroblast growth factor as a part of the growth factor signaling.: Arch Immunol Ther Exp (Warsz). 1996;44(4):201-7. Unique Identifier : AIDSLINE MED/97169611; Wiedlocha A; Department of Biochemistry, Norwegian Radium Hospital,; Montebello, Oslo, Norway.; The plasma membrane represents an impermeable barrier to proteins and other macromolecules. However, certain exogenous proteins are able to cross cellular membranes and gain access to the cytosol. The best examples are bacterial and plant protein toxins, acting on intracellular targets. During last few years the numbe
Interleukin 12 and direct cytotoxicity of spleen lymphocytes to Listeria innocua-phagocyting syngeneic macrophages in C57BL/6 and BALB/c mice.: Arch Immunol Ther Exp (Warsz). 1997;45(1):49-54. Unique Identifier : AIDSLINE MED/97245785; Szeliga J; Fiuk D; Walencka M; Goscicka T; Department of Immunology, University of Lodz, Poland.; Production of interleukin 12 (IL-12) during cytotoxic reaction of C57BL/6 and BALB/c spleen lymphocytes or their subpopulations: T+B, T, CD4+ and CD8+ cells to L. innocua-phagocyting syngeneic macrophages was examined. The effector cell donors were untreated or L. innocua-infected. The number of surviving bacteria in
Counter-regulation of T helper 1 cell proliferation by nitric oxide and interleukin-2.: Biochem Biophys Res Commun. 1997 Apr 7;233(1):14-9. Unique Identifier : AIDSLINE MED/97289482; Taylor-Robinson AW; Department of Biology, University of Leeds, United Kingdom.; bgyawtr@leeds.ac.uk; It was reported previously that cloned Th1 cells, but not Th2 cells, raised to malaria antigens, produce nitric oxide (NO) when activated with specific antigen or mitogen. Furthermore, NO inhibits the proliferation of, and production of interleukin-2 ( IL-2 ) and interfe
Generation of the replication-competent human immunodeficiency virus type 1 which expresses a jellyfish green fluorescent protein.: Biochem Biophys Res Commun. 1997 Apr 7;233(1):288-92. Unique Identifier : AIDSLINE MED/97289535; Lee AH; Han JM; Sung YC; Department of Life Science, Pohang University of Science and; Technology, Kyung-Puk, Korea.; The gene encoding a red-shifted green fluorescent protein variant (EGFP) was introduced into a human immunodeficiency virus type 1 (HIV-1) molecular clone by replacing the nef gene. The EGFP-expressing HIV-1 replicated efficiently in established human T cells. The expression of EGFP in the virus-infected cells was con
Screening of inhibitors of HIV-1 protease using an Escherichia coli cell assay.: Biochem Biophys Res Commun. 1997 Apr 7;233(1):36-8. Unique Identifier : AIDSLINE MED/97289486; Buttner J; Dornmair K; Schramm HJ; Max-Planck-Institut fur Biochemie, Martinsried, Germany.; To evaluate the available peptidic and pseudopeptidic inhibitors of HIV protease for their possible in vivo activity, a screening test using Escherichia coli was established. E. coli cells carrying the plasmid pET9c-PR containing the gene for HIV-1 protease under the control of a T7-promotor are grown in the absence a
AIDS-associated Kaposi's sarcoma cells secrete a neurotrophic growth factor(s).: Biochem Biophys Res Commun. 1997 Apr 17;233(2):408-12. Unique Identifier : AIDSLINE MED/97289643; Weeks BS; Cooney R; Department of Medicine, University of Pennsylvania, Philadelphia; 19104, USA.; Here we treat neuronal cells with AIDS-Kaposi s sarcoma cell conditioned medium (A-KSCM) in order to determine if AIDS-Kaposi s sarcoma (A-KS) cells secrete neurotrophic factors. PC12 and NG108-15 cells were differentiated and allowed to form neuronal processes. Under these conditions and in the presence of A-KSCM, PC
Undergraduate education on HIV/AIDS [letter]: Acad Med. 1997 May;72(5):319. Unique Identifier : AIDSLINE MED/97303246; Valenti WM; Stein GL
Detection of human herpesvirus 8 DNA in semen from HIV-infected individuals but not healthy semen donors [see comments]: AIDS. 1997 Feb;11(2):F15-9. Unique Identifier : AIDSLINE MED/97182318; Howard MR; Whitby D; Bahadur G; Suggett F; Boshoff C; Tenant-Flowers M; Schulz TF; Kirk S; Matthews S; Weller IV; Tedder RS; Weiss RA; Department of Virology, University College London Medical School,; UK.; OBJECTIVE: To ascertain the prevalence of Kaposi s sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus (HHV) type 8, and cytomegalovirus ( CMV ) DNA in semen was investigated. METHODS: Amplification by nested
HIV-1 Tat protein can transactivate a heterologous TATAA element independent of viral promoter sequences and the trans-activation response element.: AIDS. 1997 Feb;11(2):139-46. Unique Identifier : AIDSLINE MED/97182319; Roebuck KA; Rabbi MF; Kagnoff MF; Department of Immunology and Microbiology, Rush Presbyterian-St; Luke's Medical Center, Chicago, Illinois 60612, USA.; OBJECTIVE: To determine whether the HIV-1 transactivator protein Tat acts as a DNA sequence-specific transcription factor and activates transcription from a heterologous TATAA element in the absence of the trans-activation response (TAR) element and other sequences in the HIV-1 long terminal repeat (LTR). DESIGN: Acti
Perturbations of glucose metabolism associated with HIV infection in human intestinal epithelial cells: a multinuclear magnetic resonance spectroscopy study.: AIDS. 1997 Feb;11(2):147-55. Unique Identifier : AIDSLINE MED/97182320; Lutz NW; Yahi N; Fantini J; Cozzone PJ; Centre of Biological and Medical Magnetic Resonance, Faculty of; Medicine, CHU de la Timone, Marseille, France.; OBJECTIVE: To analyse the effect of HIV-1 infection on the glucose metabolism of human intestinal epithelial cells. METHODS: HT-29 cells were infected with HIV-1NDK and studied 3 weeks (acutely infected cells) or 9 months (chronically infected cells) post-infection. Perchloric acid extracts were analysed by high-resol
Prevention of simian immunodeficiency virus, SIVsm, or HIV-2 infection in cynomolgus monkeys by pre- and postexposure administration of BEA-005.: AIDS. 1997 Feb;11(2):157-62. Unique Identifier : AIDSLINE MED/97182321; Bottiger D; Johansson NG; Samuelsson B; Zhang H; Putkonen P; Vrang L; Oberg B; Microbiology and Tumour Biology Centre, Karolinska Institute,; Stockholm, Sweden.; OBJECTIVE: To study the possibilities and limitations of postexposure treatment to prevent the establishment of infection after accidental exposure to HIV. DESIGN AND METHODS: The effect of 2,3 -dideoxy-3 -hydroxymethyl cytidine (B1 A-005) was investigated on acute simian immunodeficiency virus (SIV) and HIV-2 infecti
Itraconazole cyclodextrin solution: the role of in vitro susceptibility testing in predicting successful treatment of HIV-related fluconazole-resistant and fluconazole-susceptible oral candidosis.: AIDS. 1997 Feb;11(2):163-8. Unique Identifier : AIDSLINE MED/97182322; Cartledge JD; Midgley J; Gazzard BG; Department of HIV & Genito-Urinary Medicine, St Stephen's Centre,; Chelsea & Westminster Healthcare NHS Trust, London, UK.; OBJECTIVES: This study assessed the ability of in vitro susceptibility testing of clinical Candida isolates to predict in vivo response to itraconazole cyclodextrin solution. METHODS: One hundred specimens were obtained from HIV-positive patients with oral thrush , of which 72 s
Correspondence between the effect of zidovudine plus lamivudine on plasma HIV level/CD4 lymphocyte count and the incidence of clinical disease in infected individuals. North American Lamivudine HIV Working Group.: AIDS. 1997 Feb;11(2):169-75. Unique Identifier : AIDSLINE MED/97182323; Phillips AN; Eron J; Bartlett J; Kuritzkes DR; Johnson VA; Gilbert C; Johnson J; Keller A; Hill AM; Department of Primary Care and Population Sciences, Royal Free; Hospital School of Medicine, London, UK.; OBJECTIVES: To investigate whether apparently beneficial changes in plasma HIV RNA level and CD4 lymphocyte count that are induced by antiretroviral therapy are associated with a corresponding clinical benefit. METHODS: For 620 patients in two randomized, double-blind trials of lamivudine (
A prospective study of criteria for the diagnosis of toxoplasmic encephalitis in 186 AIDS patients. The BIOTOXO Study Group.: AIDS. 1997 Feb;11(2):177-84. Unique Identifier : AIDSLINE MED/97182324; Raffi F; Aboulker JP; Michelet C; Reliquet V; Pelloux H; Huart A; Poizot-Martin I; Morlat P; Dupas B; Mussini JM; Leport C; Department of Infectious Diseases, University Hospital, Nantes,; France.; OBJECTIVE: To define the factors associated with diagnosis of toxoplasmic encephalitis (TE) in AIDS patients; and to establish a rational procedure for the clinician faced with a decision concerning empiric antitoxoplasma therapy. DESIGN: A 15-month prospective multicentre cohort study in
Acetyl-carnitine deficiency in AIDS patients with neurotoxicity on treatment with antiretroviral nucleoside analogues.: AIDS. 1997 Feb;11(2):185-90. Unique Identifier : AIDSLINE MED/97182325; Famularo G; Moretti S; Marcellini S; Trinchieri V; Tzantzoglou S; Santini G; Longo A; De Simone C; Department of Infectious Diseases, University of L'Aquila, Italy.; OBJECTIVE: A severe dose limiting axonal peripheral neuropathy may develop in subjects on treatment with the nucleoside analogues didanosine (ddl), zalcitabine ( ddC ), and
Sexual negotiation in the AIDS era: negotiated safety revisited.: AIDS. 1997 Feb;11(2):191-7. Unique Identifier : AIDSLINE MED/97182326; Kippax S; Noble J; Prestage G; Crawford JM; Campbell D; Baxter D; Cooper D; National Centre in HIV Social Research, Macquarie University,; Sydney, Australia.; OBJECTIVE: To test the safety of the negotiated safety strategy-the strategy of dispensing with condoms within HIV-seronegative concordant regular sexual relationships under certain conditions. METHOD: Data from recently recruited cohort of homosexually active men (Sydney Men and Sexual Health cohort, n = 1037) are
Most HIV-1 genetic subtypes have entered Sweden.: AIDS. 1997 Feb;11(2):199-202. Unique Identifier : AIDSLINE +; Alaeus A; Leitner T; Lidman K; Albert J; Division of Infectious Diseases, Karolinska Institute, Danderyds; Hospital, Stockholm, Sweden.; OBJECTIVE: The aim of this study was to document which genetic subtypes of HIV-1 have entered Sweden and to study transmission patterns of these virus variants. PATIENTS: All HIV-1 infected individuals at Danderyds Hospital, Stockholm, Sweden, who were suspected of carrying a virus
Impact of HIV/AIDS on life expectancy in the United States.: AIDS. 1997 Feb;11(2):203-7. Unique Identifier : AIDSLINE MED/97182328; Lai D; Tsai SP; Hardy RJ; School of Public Health, University of Texas, Houston 77030, USA.; OBJECTIVES: The potential gains in life expectancy of the US population by the partial and total elimination of deaths from HIV/AIDS were compared with that of deaths from heart disease and malignant neoplasms. METHODS: The data from the 1992 advanced mortality report and detailed information provided by the National
Long-term survival in patients with advanced immunodeficiency.: AIDS. 1997 Feb;11(2):209-16. Unique Identifier : AIDSLINE MED/97182329; Chene G; Easterbrook PJ; Juszczak E; Yu LM; Pocock SJ; Gazzard BG; Medical Statistics Unit, London School of Hygiene and Tropical; Medicine, Chelsea and Wistminster Hospital, London, UK.; OBJECTIVE: To identity prognostic factors associated with survival time in HIV-infected patients with advanced immunodeficiency. DESIGN: Prospective cohort study. PARTICIPANTS: A total of 1284 HIV-infected patients with serial CD4 count measurements and at least one CD4 cell count
Dependence of the hazard of AIDS on markers.: AIDS. 1997 Feb;11(2):217-28. Unique Identifier : AIDSLINE MED/97182330; Yong FH; Taylor JM; Bryant JL; Chmiel JS; Gange SJ; Hoover D; Center for Biostatistics in AIDS Research, Harvard School of; Public Health, Boston, Massachusetts 02115, USA.; OBJECTIVE: To investigate the dependence of the hazard of symptomatic AIDS on various markers using a non-parametric method. The markers we consider are measures of time (time since infection and calendar date), measures of immune function (numbers and percentage of CD4 T cells) and serological activation markers (neo
Sex, drugs and HIV counseling and testing: a prospective study of behavior-change among methadone-maintenance clients in New England.: AIDS. 1997 Feb;11(2):229-35. Unique Identifier : AIDSLINE MED/97182331; MacGowan RJ; Brackbill RM; Rugg DL; Swanson NM; Weinstein B; Couchon A; Scibak J; Molde S; McLaughlin P; Barker T; Voigt R; National Center for HIV/STD/TB Prevention, Centers for Disease; Control and Prevention, Atlanta, Georgia 30333, USA.; OBJECTIVES: To determine whether changes in injecting drug use and sexual behavior over a 12-month follow-up are associated with HIV counseling and testing (C and T) of injecting drug users in methadone maintenance treatment programs (MMTP) in Massachusetts and Connecticut. METHODS: Clients were invited to participate
Sexual behaviour patterns and other risk factors for HIV infection in rural Tanzania: a case-control study.: AIDS. 1997 Feb;11(2):237-48. Unique Identifier : AIDSLINE MED/97182332; Quigley M; Munguti K; Grosskurth H; Todd J; Mosha F; Senkoro K; Newell J; Mayaud P; ka-Gina G; Klokke A; Mabey D; Gavyole A; Hayes R; London School of Hygiene and Tropical Medicine, UK.; OBJECTIVE: To examine the association between HIV infection and patterns of sexual behaviour and other risk factors in a rural Tanzanian population in a case-control study, nested within a randomized trial of improved sexually transmitted disease treatment. METHODS: All HIV-positive patients from the baseline survey o
Human herpesvirus 8 in semen and prostate [editorial; comment]: AIDS. 1997 Feb;11(2):249-50. Unique Identifier : AIDSLINE MED/97182333; Blackbourn DJ; Levy JA
Significance of restricted HIV expression for HIV neuropathogenesis: still an unresolved issue [letter]: AIDS. 1997 Feb;11(2):251-2. Unique Identifier : AIDSLINE MED/97182334; Brack-Werner R; Erfle V; Ranki A
No evidence of significant abortive HIV infection of the brain [letter]: AIDS. 1997 Feb;11(2):252. Unique Identifier : AIDSLINE MED/97182335; Wiley CA; Achim CL
Rhodococcus or mycobacterium? An example of misdiagnosis in HIV infection [letter]: AIDS. 1997 Feb;11(2):253-4. Unique Identifier : AIDSLINE MED/97182336; Macias J; Pineda JA; Borderas F; Gallardo JA; Delgado J; Leal M; Sanchez-Quijano A; Lissen E
Topical foscarnet for aciclovir-resistant mucocutaneous herpes infections in AIDS [letter]: AIDS. 1997 Feb;11(2):254-5. Unique Identifier : AIDSLINE MED/97182337; Smith NA; Wood C; Asboe D; Bingham JS
Identification of Mycobacterium genavense in intestinal tissue from a parakeet using two polymerase chain reaction methods: are pets a reservoir of infection in AIDS patients? [letter]: AIDS. 1997 Feb;11(2):255-6. Unique Identifier : AIDSLINE MED/97182338; Boian M; Avaniss-Aghajani E; Walker R; Aronson T; Tran T; Glover N; Berlin OG; Woods L; Brunk C; Li JL; Froman S; Holtzman A
Macrophage inflammatory protein-1 alpha mRNA expression in mononuclear cells from different tissues during acute simian immunodeficiency virus strain mac251 infection of macaques [letter]: AIDS. 1997 Feb;11(2):257-8. Unique Identifier : AIDSLINE MED/97182339; Cheret A; Caufour P; Le Grand R; Theodoro F; Boussin F; Vaslin B; Dormont D
Convenient twice daily foscarnet in induction therapy of AIDS-associated cytomegalovirus retinitis. The Foscarnet Italian Study Group [letter]: AIDS. 1997 Feb;11(2):258-60. Unique Identifier : AIDSLINE MED/97182340; Carosi G; Castelli F; Lernestedt JO; Antoniazzi E; Gerna G
Solitary cutaneous cryptococcosis resembling chickenpox: a case report [letter]: AIDS. 1997 Feb;11(2):260-1. Unique Identifier : AIDSLINE MED/97182341; Martinelli C; Comin CE; Ambu S; Bartolozzi D; Leoncini F
Regression of AIDS-related Kaposi's sarcoma following treatment with an HIV-1 protease inhibitor [letter]: AIDS. 1997 Feb;11(2):261-2. Unique Identifier : AIDSLINE MED/97182342; Murphy M; Armstrong D; Sepkowitz KA; Ahkami RN; Myskowski PL
Renal involvement in the diffuse infiltrative CD8 lymphocytosis syndrome [letter]: AIDS. 1997 Feb;11(2):262-3. Unique Identifier : AIDSLINE MED/97182343; Lesprit P; Fornairon S; Michaut P; Nochy D; Idatte JM; Modai J
On returning for one's HIV test result: demographic, behavioral and psychological predictors [letter]: AIDS. 1997 Feb;11(2):263-4. Unique Identifier : AIDSLINE MED/97182344; Bell RA; Molitor F; Flynn N
Focusing on the second phase of plasma HIV-1 RNA clearance [letter]: AIDS. 1997 Feb;11(2):264-6. Unique Identifier : AIDSLINE MED/97182345; Lafeuillade A; Poggi C; Sayada C; Pellegrino P; Profizi N
Disseminated granulomatous disease in a simian immunodeficiency virus- and bacille Calmette-Guerin-infected rhesus monkey [letter]: AIDS. 1997 Feb;11(2):266-7. Unique Identifier : AIDSLINE MED/97182346; Chen ZW; Zhou D; Chalifoux L; Lee-Parritz D; Mansfield K; Lord CI; Letvin NL
Rapid fatal evolution in two cases of infection due to HIV-1 uncommon subtypes in France [letter]: AIDS. 1997 Feb;11(2):267-8. Unique Identifier : AIDSLINE MED/97182347; Lacassin F; Loussert-Ajaka L; Leport C; Brun-Vezinet F; Vilde JL; Simon F
Saquinavir interaction with midazolam: pharmacokinetic considerations when prescribing protease inhibitors for patients with HIV disease [letter]: AIDS. 1997 Feb;11(2):268-9. Unique Identifier : AIDSLINE MED/97182348; Merry C; Mulcahy F; Barry M; Gibbons S; Back D
Absence of human herpesvirus 8 sequences in prostate specimens [letter]: AIDS. 1997 Feb;11(2):270. Unique Identifier : AIDSLINE MED/97182349; Lebbe C; Pellet C; Tatoud R; Agbalika F; Dosquet P; Desgrez JP; Morel P; Calvo F
Visualization of human herpesvirus type 8 in Kaposi's sarcoma by light and transmission electron microscopy.: AIDS. 1997 Apr;11(5):F35-45. Unique Identifier : AIDSLINE MED/97262651; Orenstein JM; Alkan S; Blauvelt A; Jeang KT; Weinstein MD; Ganem D; Herndier B; Department of Pathology, George Washington University,; Washington, DC, USA.; BACKGROUND: Human herpesvirus type 8 (HHV-8) has been associated with Kaposi s sarcoma, body cavity-based lymphoma (BCBL), and multicentric Castleman s disease through DNA, in situ hybridization, and serologic studies. HHV-8 has been visualized only in HHV-8-positive/Epstein-Barr virus (EBV)-negative/
Candidiasis: the emergence of a novel species, Candida dubliniensis [editorial]: AIDS. 1997 Apr;11(5):557-67. Unique Identifier : AIDSLINE MED/97262652; Coleman DC; Sullivan DJ; Bennett DE; Moran GP; Barry HJ; Shanley DB
Leishmania infantum is clonal in AIDS patients too: epidemiological implications.: AIDS. 1997 Apr;11(5):569-73. Unique Identifier : AIDSLINE MED/97262653; Jimenez M; Alvar J; Tibayrenc M; Laboratory of Parasitology, Institute of Salud Carlos III,; Madrid, Spain.; OBJECTIVE: To test, in AIDS patients, a previously proposed hypothesis of clonal population structure in Leishmania infantum, the agent of visceral leishmaniasis. DESIGN: Forty-three stocks of L. infantum isolated from AIDS patients in Spain were analysed by multilocus enzyme electr
CD8+ T-cell-mediated suppression of HIV-1 long terminal repeat-driven gene expression is not modulated by the CC chemokines RANTES, macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta.: AIDS. 1997 Apr;11(5):575-80. Unique Identifier : AIDSLINE MED/97262654; Leith JG; Copeland KF; McKay PJ; Richards CD; Rosenthal KL; Department of Pathology, McMaster University Health Sciences; Centre, Hamilton, Ontario, Canada.; OBJECTIVE: To assess the role of RANTES, macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta in modulation of HIV-1 long terminal repeat (LTR)-mediated gene expression and determine whether these chemokines share identity with CD8+ T-lymphocyte-derived HIV-1 LTR-suppressive factors. DESIGN: HIV-1 LTR-directed
CD8+ T cell-mediated suppression of HIV long terminal repeat-driven gene expression is not associated with improved clinical status.: AIDS. 1997 Apr;11(5):581-6. Unique Identifier : AIDSLINE MED/97262655; Copeland KF; Leith JG; McKay PJ; Kelleher L; Smaill FM; Rosenthal KL; Molecular Virology and Immunology Programme, McMaster University,; Hamilton, Ontario, Canada.; OBJECTIVES: To determine the associations between the suppression of HIV-1 long terminal repeat (LTR)-mediated gene expression by CD8+ T-cell supernatants and clinical correlates of well-being, including CD4+ and CD8+ T-cell counts, beta-chemokine production and clinical stage of disease. METHODS: Culture supernatants
Enhancement or inhibition of HIV-1 replication by intracellular expression of sense or antisense RNA targeted at different intermediates of reverse transcription.: AIDS. 1997 Apr;11(5):587-95. Unique Identifier : AIDSLINE MED/97262656; Peng H; Callison DE; Li P; Burrell CJ; National Centre for HIV Virology Research, University of; Adelaide, South Australia.; OBJECTIVES: To construct retroviral vectors expressing sense or antisense RNA targeted at HIV reverse transcription intermediates, and to test the anti-HIV properties of these constructs in transduced T cells. DESIGN: Five double-copy retroviral vectors were constructed, in which the expression of the sense or antisen
Interactions between HIV and hepatitis B virus in homosexual men: effects on the natural history of infection.: AIDS. 1997 Apr;11(5):597-606. Unique Identifier : AIDSLINE MED/97262657; Gilson RJ; Hawkins AE; Beecham MR; Ross E; Waite J; Briggs M; McNally T; Kelly GE; Tedder RS; Weller IV; Department of Sexually transmitted Diseases, University College; London Medical School, UK.; OBJECTIVES: Hepatitis B virus (HBV) and HIV infections share risk-factors; therefore coinfection is common. Interactions have been reported but controlled studies have been limited. Our objective was to study the effect of HIV infection on the natural history of chronic HBV infection and the reverse effect of the HBV
Human herpesvirus type 8 DNA sequences in biological samples of HIV-positive and negative individuals in Sicily.: AIDS. 1997 Apr;11(5):607-12. Unique Identifier : AIDSLINE MED/97262658; Viviano E; Vitale F; Ajello F; Perna AM; Villafrate MR; Bonura F; Arico M; Mazzola G; Romano N; Dipartimento di Igiene e Microbiologia G. D'Alessandro,; Universita degli Studi, Palermo, Italy.; OBJECTIVE: To evaluate the circulation of a new human herpesvirus (HHV), HHV-8 or Kaposi s sarcoma (KS)-associated herpesvirus in a geographical area where a high incidence rate of classical KS was already present before the appearance of the AIDS epidemic. DESIGN AND METHODS: The study was carried out by analysing: (
Association between serum vitamin A and E levels and HIV-1 disease progression.: AIDS. 1997 Apr;11(5):613-20. Unique Identifier : AIDSLINE MED/97262659; Tang AM; Graham NM; Semba RD; Saah AJ; Department of Epidemiology, Johns Hopkins University School of; Medicine, Baltimore, Maryland, USA.; OBJECTIVE: To examine the associations between serum vitamin A and E levels and risk of progression to three key outcomes in HIV-1 infection: first AIDS diagnosis, CD4+ cell decline to
Comparison of progression and non-progression in injecting drug users and homosexual men with documented dates of HIV-1 seroconversion. European Seroconverter Study and the Tricontinental Seroconverter Study.: AIDS. 1997 Apr;11(5):621-31. Unique Identifier : AIDSLINE MED/97262660; Prins M; Veugelers PJ; Municipal Health Service, Division of Public Health and; Environment, Amsterdam, The Netherlands.; OBJECTIVE: To compare the progression and non-progression of HIV infection among 418 injecting drug users (IDU) and 422 homosexual men with documented dates of HIV seroconversion from 12 cohorts. METHODS: Seroconversion dates were calculated for each subject using a cohort-specific estimate of the cumulative HIV seroi
An HIV-1 natural history cohort and survival times in rural Uganda.: AIDS. 1997 Apr;11(5):633-40. Unique Identifier : AIDSLINE MED/97262661; Morgan D; Malamba SS; Maude GH; Okongo MJ; Wagner HU; Mulder DW; Whitworth JA; Medical Research Council Programme on AIDS, Uganda Virus Research; Institute, Entebbe, Uganda.; OBJECTIVE: To describe a population-based rural cohort of HIV-1-seropositive and seronegative individuals established in 1990 in south-west Uganda , and determine survival times in the cohort. DESIGN: Prospective cohort study. METHODS: Participants were recruited from a large popula
Concurrent partnerships and the spread of HIV [see comments]: AIDS. 1997 Apr;11(5):641-8. Unique Identifier : AIDSLINE MED/97262662; Morris M; Kretzschmar M; Department of Sociology, Pennsylvania State University,; University Park, USA.; OBJECTIVE: To examine how concurrent partnerships amplify the rate of HIV spread, using methods that can be supported by feasible data collection. METHODS: A fully stochastic simulation is used to represent a population of individuals, the sexual partnerships that they form and dissolve over time, and the spread of an
Reconstruction and prediction of the HIV/AIDS epidemic among adults in the European Union and in the low prevalence countries of central and eastern Europe.: AIDS. 1997 Apr;11(5):649-62. Unique Identifier : AIDSLINE MED/97262663; Downs AM; Heisterkamp SH; Brunet JB; Hamers FF; European Centre for the Epidemiological Monitoring of AIDS,; Saint-Maurice, France.; OBJECTIVES: To reconstruct the HIV epidemic and to provide forecasts of AIDS incidence among adults in the European Union (EU) and in a group of low prevalence (LP) countries of central and eastern Europe (including the Asian republics of the former Soviet Union). METHODS: An empirical Bayesian back-calculation method
Fertility and reproductive choice in women with HIV-1 infection.: AIDS. 1997 Apr;11(5):663-7. Unique Identifier : AIDSLINE MED/97262664; Thackway SV; Furner V; Mijch A; Cooper DA; Holland D; Martinez P; Shaw D; van Beek I; Wright E; Clezy K; Kaldor JM; National Centre in HIV Epidemiology and Clinical Research,; Sydney, Australia.; OBJECTIVE: To measure fertility and birth rates and to describe the reproductive histories of women diagnosed with HIV-1 infection in Australia . METHODS: The medical records of 294 women with HIV-1 infection in four states of Australia were reviewed. Expected fertility and birth
The risks and benefits of childhood bacille Calmette-Guerin immunization among adults with AIDS. International MAC study groups.: AIDS. 1997 Apr;11(5):669-72. Unique Identifier : AIDSLINE MED/97262665; Marsh BJ; von Reyn CF; Edwards J; Ristola MA; Bartholomew C; Brindle RJ; Gilks CF; Waddell R; Tosteson AN; Pelz R; Sox CH; Frothingham R; Arbeit RD; Infectious Disease Section, Dartmouth-Hitchcock Medical Center,; Lebanon, NH 03756, USA.; OBJECTIVE: To define the risks of disseminated bacille Calmette-Guerin (BCG) or disseminated Mycobacterium tuberculosis in adults with AIDS who were immunized with BCG in childhood. DESIGN: HIV-infected patients with CD4
Incidence and factors associated with extrapulmonary cryptococcosis among persons with HIV infection in Los Angeles County.: AIDS. 1997 Apr;11(5):673-9. Unique Identifier : AIDSLINE MED/97262666; Sorvillo F; Beall G; Turner PA; Beer VL; Kovacs AA; Kerndt PR; HIV Epidemiology Program, Los Angeles County Department of Health; Services, CA 90005, USA.; OBJECTIVE: To determine the incidence and factors associated with extrapulmonary cryptococcosis among a cohort of persons with HIV in Los Angeles County. DESIGN: Records-based cohort study. METHODS: Data were analysed from a cohort of 3836 persons aged > or = 13 years with HIV infection enrolled from four outpatient f
Coining a new term in epidemiology: concurrency and HIV [editorial; comment]: AIDS. 1997 Apr;11(5):681-3. Unique Identifier : AIDSLINE MED/97262667; Garnett GP; Johnson AM
HIV infection in female prostitutes from Benin: association with symptomatic but not asymptomatic gonococcal or chlamydial infections [letter]: AIDS. 1997 Apr;11(5):685-6. Unique Identifier : AIDSLINE MED/97262668; Baganizi E; Alary M; Guedeme A; Padonou F; Davo N; Adjovi C; van Dyck E; Germain M; Joly JR; Mahony JB
Prevalence and incidence rates of HIV-1 infection in Rwandan students [letter]: AIDS. 1997 Apr;11(5):686-7. Unique Identifier : AIDSLINE MED/97262669; Baganizi E; Saah A; Bulterys M; Hoover DR; Celentano D; Alary M
Kaposi's sarcoma and sex hormones [letter]: AIDS. 1997 Apr;11(5):687-8. Unique Identifier : AIDSLINE MED/97262670; Bouscarat F; Dazza MC; Melchior JC; Bouvet E
CC-chemokine receptor 5 genotypes and in vitro susceptibility to HIV-1 of a cohort of British HIV-exposed uninfected homosexual men [letter]: AIDS. 1997 Apr;11(5):688-9. Unique Identifier : AIDSLINE MED/97262671; Aarons E; Fernandez M; Rees A; McClure M; Weber J
Nutritional status and survival in HIV-1 disease [letter]: AIDS. 1997 Apr;11(5):689-90. Unique Identifier : AIDSLINE MED/97262672; Baum MK; Shor-Posner G
HIV encephalitis and HIV leukoencephalopathy are associated with distinct clinical and radiological subtypes of the AIDS dementia complex [letter]: AIDS. 1997 Apr;11(5):690-1. Unique Identifier : AIDSLINE MED/97262673; Grassi MP; Clerici F; Boldorini R; Perin C; Vago L; D'Arminio Monforte A; Borella M; Nebuloni M; Mangoni A
No relationship between age and HIV risk behaviour among Sydney gay men [letter]: AIDS. 1997 Apr;11(5):691-3. Unique Identifier : AIDSLINE MED/97262674; Van de Ven P; Kippax S; Crawford J; French J; Prestage G; Grulich A; Kinder P; Kaldor J
Potential role for granulocyte-macrophage colony-stimulating factor in the treatment of HIV-associated cryptococcal meningitis [letter]: AIDS. 1997 Apr;11(5):693-4. Unique Identifier : AIDSLINE MED/97262675; Price DA; Klein JL; Fisher M; Main J; Bingham JS; Coker RJ
Dual infection with different strains of the same HIV-1 subtype [letter]: AIDS. 1997 Apr;11(5):694-6. Unique Identifier : AIDSLINE MED/97262676; Butto S; Argentini C; Mazzella AM; Iannotti MP; Leone P; Leone P; Nicolosi A; Rezza G
Lack of emergence of genotypic resistance to stavudine after 2 years of monotherapy [letter]: AIDS. 1997 Apr;11(5):696-7. Unique Identifier : AIDSLINE MED/97262677; Soriano V; Dietrich U; Villalba N; Immelmann A; Gil-Aguado A; Echevarria S; Clotet B; Ocana I; Santamaria JM; Bouza E; Barona V; Gatell JM; Gonzalez-Lahoz J
Totally implantable venous access device infections in patients with AIDS [letter]: AIDS. 1997 Apr;11(5):697-8. Unique Identifier : AIDSLINE MED/97262678; Hellard M; Fuller A; Spelman D; Spicer WJ; Pickles R; Jenney A
In vivo evidence of HIV-1 productive infection in cerebrospinal fluid of patients with HIV-1 encephalopathy [letter]: AIDS. 1997 Apr;11(5):698-9. Unique Identifier : AIDSLINE MED/97262679; Di Stefano M; Monno L; Ramon Fiore J; Angarano G
Estimate of HIV incidence in childbearing women in the Paris area, France [letter]: AIDS. 1997 Apr;11(5):699-701. Unique Identifier : AIDSLINE MED/97262680; Goubar A; Costagliola D
Comparison of CD4+ T-cell counts in men and women recently diagnosed with HIV infection in Mexico City, Mexico [letter]: AIDS. 1997 Apr;11(5):701-2. Unique Identifier : AIDSLINE MED/97262681; Guarner J; Uribe-Zuniga P; Hernandez-Tepichin G; Teran-Toledo X; del Rio C
Zidovudine-resistant variants of HIV-1 in lung [letter]: AIDS. 1997 Apr;11(5):702-3. Unique Identifier : AIDSLINE MED/97262682; Gates A; Coker R; Miller R; Mitchell D; Williamson J; Clarke J
HIV and syphilis prevalence in chittagong, Bangladesh [letter]: AIDS. 1997 Apr;11(5):703-4. Unique Identifier : AIDSLINE MED/97262683; Rich JD; Nizam R; Das K; Islam S; Akhtar N; Dickinson BP; Flanigan TP; Mayer K; Carpenter CC
Potential role of dideoxyinosine and hydroxyurea combination in prophylaxis of HIV infection after accidental percutaneous exposure [letter]: AIDS Res Hum Retroviruses. 1997 Mar 20;13(5):367-9. Unique Identifier : AIDSLINE MED/97229913; Raharinivo B; Meylan PR
Human submandibular saliva specifically inhibits HIV type 1.: AIDS Res Hum Retroviruses. 1997 Mar 20;13(5):371-6. Unique Identifier : AIDSLINE MED/97229914; Nagashunmugam T; Friedman HM; Davis C; Kennedy S; Goldstein LT; Malamud D; Division of Infectious Diseases, School of Medicine, University; of Pennsylvania, Philadelphia 19104, USA.; Studies from a number of laboratories have shown the presence of factor(s) in whole, parotid, and submandibular human saliva capable of inhibiting HIV-1 infectivity in vitro. Data from our laboratory suggested that the level of anti-HIV-1 activity is higher in submandibular than parotid or whole saliva. Previous resul
Reactivation of HIV type 1 in chronically infected chimpanzees following xenostimulation with human cells or with pulses of corticosteroid.: AIDS Res Hum Retroviruses. 1997 Mar 20;13(5):377-81. Unique Identifier : AIDSLINE MED/97229915; Shibata R; Siemon C; Rizvi TA; Matano T; Satterfield WC; Lane HC; Martin MA; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA.; Following resolution of a primary HIV-1 infection initially induced by inoculating a mixture of three different virus strains, a chimpanzee was exposed to both immunostimulatory and immunosuppressive agents in an attempt to assess the contributions of different components of the immune system in suppressing circulatin
Recognition of a small number of diverse epitopes dominates the cytotoxic T lymphocytes response to HIV type 1 in an infected individual.: AIDS Res Hum Retroviruses. 1997 Mar 20;13(5):383-92. Unique Identifier : AIDSLINE MED/97229916; Lieberman J; Fabry JA; Fong DM; Parkerson GR 3rd; Center for Blood Research, Harvard Medical School, Boston,; Massachusetts 02111, USA.; Mitogen-activated T cell lines may be reproducibly used to identify relatively conserved HIV-1 epitopes that dominate CTL recognition of HIV-infected cells. Using a combination of nested truncations of HIV-vaccinia recombinants encoding HIV-1LAI Env and overlapping peptides that span the coding regions of the HIV-1 SF
Gag-specific immune responses after immunization with p17/p24:Ty virus-like particles in HIV type 1-seropositive individuals.: AIDS Res Hum Retroviruses. 1997 Mar 20;13(5):393-9. Unique Identifier : AIDSLINE MED/97229917; Klein MR; Veenstra J; Holwerda AM; Roos MT; Gow I; Patou G; Coutinho RA; De Wolf F; Miedema F; Department of Clinical Viro-Immunology, Central Laboratory of The; Netherlands Red Cross Blood Transfusion Service, Amsterdam, The; Netherlands.; Gag-specific immune responses and changes in HIV-1 RNA levels were evaluated in eight HIV-1-infected persons, in order to assess the immunotherapeutic potential HIV-1 p17/p24: Ty virus-like particles (p24-VLP). All treated subjects showed transient and dose-dependent proliferative responses to the Ty-VLP carrier (stim
Genetic variation in human immunodeficiency virus type 2: identification of a unique variant from human plasma.: AIDS Res Hum Retroviruses. 1997 Mar 20;13(5):401-4. Unique Identifier : AIDSLINE GENBANK/U67395; Brennan CA; Yamaguchi J; Vallari AS; Hickman RK; Devare SG; Abbott Laboratories, Viral Discovery, North Chicago, Illinois; 60064, USA.
Comparative efficiency of feline immunodeficiency virus infection by DNA inoculation.: AIDS Res Hum Retroviruses. 1997 Mar 20;13(5):405-12. Unique Identifier : AIDSLINE GENBANK/M25381; Rigby MA; Hosie MJ; Willett BJ; Mackay N; McDonald M; Cannon C; Dunsford T; Jarrett O; Neil JC; Department of Veterinary Pathology, University of Glasgow; Veterinary School, UK.; Direct inoculation of genetic material in DNA form is a novel approach to vaccination that has proved efficacious for a number of viral agents. We are interested in the potential of this approach for the delivery of vaccines based on attenuated or replication-defective retroviruses. Toward this goal, we tested the eff
Focal segmental glomerulosclerosis in primates infected with a simian immunodeficiency virus.: AIDS Res Hum Retroviruses. 1997 Mar 20;13(5):413-24. Unique Identifier : AIDSLINE MED/97229920; Alpers CE; Tsai CC; Hudkins KL; Cui Y; Kuller L; Benveniste RE; Ward JM; Morton WR; Department of Pathology, School of Medicine, University of; Washington, Seattle 98195, USA.; Focal and segmental glomerulosclerosis (FSG) with endothelial tubuloreticular inclusions (TRIs) is the typical lesion of human HIV-associated glomerulopathy. Autopsy studies showed the presence of FSG in 3 of 15 macaques dying 15-120 weeks after experimental infection with a simian immunodeficiency virus (SIVMne). Ult
Simian T cell leukemia virus type I from naturally infected feral monkeys from central and west Africa encodes a 91-amino acid p12 (ORF-I) protein as opposed to a 99-amino acid protein encoded by HTLV type I from humans.: AIDS Res Hum Retroviruses. 1997 Mar 20;13(5):425-32. Unique Identifier : AIDSLINE MED/97229921; Saksena NK; Srinivasan A; Ge YC; Xiang SH; Azad A; Bolton W; Herve V; Reddy S; Diop O; Miranda-Saksena M; Rawlinson WD; Vandamme AM; Barre-Sinoussi F; Retroviral Genetics Laboratory, Westmead Institute for Health; Research, Westmead Hospital, NSW, Sydney, Australia.; A single protein of 12 kDa, p12 is encoded by the HTLV-I genome from both the singly spliced mRNA pX-ORF-I and doubly spliced mRNA pX-rex-ORF-I. While many full-length sequences of HTLV-1 are known, data on the p12 regions of African STLV-I are unavailable. We have undertaken to sequence the p12 gene in STLV-I from Ce
Simultaneous detection of simian retrovirus type D serotypes 1, 2, and 3 by polymerase chain reaction.: AIDS Res Hum Retroviruses. 1997 Mar 20;13(5):433-7. Unique Identifier : AIDSLINE MED/97229922; Liska V; Lerche NW; Ruprecht RM; Laboratory of Viral Pathogenesis, Dana-Farber Cancer Institute,; Boston, Massachusetts 02115, USA.; Asymptomatic infection of macaques with macaques with simian retroviruses type D (SRV/D), the etiologic agents of one form of retrovirus-induced simian immunodeficiency disease, can confound experiments with the simian immunodeficiency virus (SIV), which also induces immunodeficiency disease in macaques. The SIV/macaq
Evidence of HIV-2 infection in Equatorial Guinea (central Africa): partial genetic analysis of a B subtype virus.: AIDS Res Hum Retroviruses. 1997 Mar 20;13(5):439-40. Unique Identifier : AIDSLINE GENBANK/U85261; Heredia A; Vallejo A; Soriano V; Gutierrez M; Puente S; Epstein JS; Hewlett IK; Laboratory of Molecular Virology, Food and Drug Administration,; Rockville, Maryland 20852, USA.
Nucleotide-induced stable complex formation by HIV-1 reverse transcriptase.: Biochemistry. 1997 May 13;36(19):5749-57. Unique Identifier : AIDSLINE MED/97297783; Tong W; Lu CD; Sharma SK; Matsuura S; So AG; Scott WA; Department of Biochemistry and Molecular Biology, University of; Miami School of Medicine, Florida 33101, USA.; Nondenaturing gel electrophoresis was used to study the nucleotide substrate-induced conformational change in reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1). Dead-end complex was formed between HIV-1 RT, dideoxynucleotide chain-terminated primer, and DNA template in the presence of deoxynucl
Mutating a conserved motif of the HIV-1 reverse transcriptase palm subdomain alters primer utilization.: Biochemistry. 1997 May 13;36(19):5758-68. Unique Identifier : AIDSLINE MED/97297784; Ghosh M; Williams J; Powell MD; Levin JG; Le Grice SF; Division of Infectious Diseases and Center for AIDS Research,; Case Western University School of Medicine, Cleveland, Ohio; 44106-4984, USA.; In order to investigate how primer grip residues of human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) contribute toward the architecture of its palm subdomain and neighboring structural elements, the DNA polymerase and ribonuclease H (RNase H) activities of enzymes bearing aromatic substitutions at
Escape mutants of HIV-1 proteinase: enzymic efficiency and susceptibility to inhibition.: Biochim Biophys Acta. 1997 Apr 25;1339(1):113-25. Unique Identifier : AIDSLINE MED/97307764; Wilson SI; Phylip LH; Mills JS; Gulnik SV; Erickson JW; Dunn BM; Kay J; School of Molecular and Medical Biosciences, University of Wales; College of Cardiff, UK.; Genes encoding a number of mutants of HIV-1 proteinase were sub-cloned and expressed in E. coli. The proteinases containing mutations of single residues (e.g., G48V, V82F, I84V and L90M) were purified and their catalytic efficiencies relative to that of wild-type proteinase were examined using a polyprotein (recombina
Peyronie's disease [editorial]: Int J STD AIDS. 1997 Mar;8(3):141-4. Unique Identifier : AIDSLINE MED/97244213; McCahy PJ; Tayal SC
The development of a gene therapy for HIV infection.: Int J STD AIDS. 1997 Mar;8(3):145-7; quiz 148-9. Unique Identifier : AIDSLINE MED/97244214; Poznansky MC; Adams GB; Department of Infectious Diseases Medicine, Harvard Medical; School, Boston, MA 02115, USA.
Satisfaction with care of patients attending a dedicated dental clinic: comparisons between 1989 and 1994.: Int J STD AIDS. 1997 Mar;8(3):150-3. Unique Identifier : AIDSLINE MED/97244215; Croucher R; Robinson P; Zakrzewska JM; Cooper H; Greenwood I; Department of Dental Public Health, St Bartholomew's School of; Medicine and Dentistry, London, UK.; This investigation aimed to audit patient satisfaction with care at a dedicated dental clinic, using previously developed standards and criteria. A self-complete questionnaire was administered to a group of 161 patients assessing the dimensions of care availability, affective behaviour and technical competence. Compar
Use of GUM services and information and views held by first time service users in a large UK city: implications for information provision.: Int J STD AIDS. 1997 Mar;8(3):154-8. Unique Identifier : AIDSLINE MED/97244216; McClean HL; Reid M; Department of Genitourinary Medicine, Royal Infirmary University; NHS Trust, Glasgow, UK.; The aim of this study was to examine the relationship between information and views held by service users before obtaining help from a genitourinary medicine (GUM) service and the accessibility and use of the service, and to determine potential intervention measures for change. A structured questionnaire was completed
Young women's sexual risk taking behaviour: re-visiting the influences of sexual self-efficacy and sexual self-esteem.: Int J STD AIDS. 1997 Mar;8(3):159-65. Unique Identifier : AIDSLINE MED/97244217; Seal A; Minichiello V; Omodei M; Department of Health Studies, University of New England, New; South Wales, Australia.; This study investigates the influences on young women s sexual risk taking of (a) attitudes such as sexual self-efficacy and sexual self-esteem and (b) personal and sexual characteristics, such as age, the age of first sexual experience, the number of sexual partners and reported overall amount of sex. Three hundred a
Anonymous HIV surveillance with risk-factor elicitation: at Perth (for men) and Cornton Vale (for women) prisons in Scotland.: Int J STD AIDS. 1997 Mar;8(3):166-75. Unique Identifier : AIDSLINE MED/97244218; Gore SM; Bird AG; Burns S; Ross AJ; Goldberg D; MRC Biostatistics Unit, Institute of Public Health, Cambridge,; UK.; 434 male and 145 female prisoners were available to participate in cross-sectional, voluntary anonymous HIV surveillance (using saliva samples) with linked self-completion questionnaire at HMP (Her Majesty s Prison) Perth on 17 May and at HMP Cornton Vale on 18 May 1995. Three hundred and four men (70%) and 136 women
Determinants of high-risk sexual behaviour and condom use among adults in the Arusha region, Tanzania.: Int J STD AIDS. 1997 Mar;8(3):176-83. Unique Identifier : AIDSLINE MED/97244219; Mnyika KS; Klepp KI; Kv~ale G; Ole-Kingori N; Department of Epidemiology & Biostatistics, Muhimbili University; College of Health Sciences, Dar es Salaam, Tanzania.; Determinants of multiple sexual partners and condom use among adults were assessed through a population-based survey in one urban, one semi-urban and one rural community in the Arusha region, northern Tanzania . The study samples were obtained by randomly selecting clusters of 10
Parvovirus B19 infection in AIDS patients.: Int J STD AIDS. 1997 Mar;8(3):184-6. Unique Identifier : AIDSLINE MED/97244220; Kerr JR; Kane D; Crowley B; Leonard N; O'Briain S; Coyle PV; Mulcahy F; Department of Bacteriology, Belfast City Hospital, Northern; Ireland.; Bone marrow of 61 HIV-1-infected patients and 23 control patients was examined to determine the incidence of B19 infection and its clinical impact in HIV-1-infected persons. Of the 61 HIV-infected patients studied, ages ranged from 22-47 years with a mean of 33.2 years. There was a man:woman ratio of 3.8:1. With regar
Demographic data on prostitutes from Bulgaria--a recruitment country for international (migratory) prostitutes.: Int J STD AIDS. 1997 Mar;8(3):187-91. Unique Identifier : AIDSLINE MED/97244221; Tchoudomirova K; Domeika M; M~ardh PA; Uppsala University Centre for STD Research, Institute of Clinical; Bacteriology, Uppsala University, Sweden.; The study was aimed at investigating the conditions and circumstances for the recruitment of prostitutes, as well as their reproductive history, working conditions, knowledge of and attitudes to sexually transmitted diseases (STDs), and use of prophylactic antibiotic therapy of these diseases. Two hundred prostitutes
An evaluation of the capillus HIV-1/HIV-2 latex agglutination test using serum and whole blood.: Int J STD AIDS. 1997 Mar;8(3):192-5. Unique Identifier : AIDSLINE MED/97244222; Windsor IM; Gomes dos Santos ML; de la Hunt LI; Wadee AA; Khumalo S; Radebe F; Dangor Y; Ballard RC; Department of Immunology, School of Pathology, South African; Institute for Medical Research, South Africa.; The capillus HIV-1/HIV-2 latex agglutination (LA) test was evaluated for its potential as an initial screening test in primary health care. For the serum study, panels totalling 289 HIV-positive sera and 323 known HIV-negative sera plus 50 individual seroconversion samples were tested by capillus. Paired blood specime
Sexual behaviour and sex education in Irish school-going teenagers.: Int J STD AIDS. 1997 Mar;8(3):196-200. Unique Identifier : AIDSLINE MED/97244223; MacHale E; Newell J; Clinical Science Institute, University College, Galway, UK.; The sexual behaviour and factors which affect such behaviour, source of knowledge and education about sex was assessed by means of an anonymous self-administered questionnaire among 2754 pupils (15-18 years) attending 40 (85%) second level schools in Galway City and County. The purpose of the study was to make recomme
Irreversible ototoxicity associated with zalcitabine.: Int J STD AIDS. 1997 Mar;8(3):201-2. Unique Identifier : AIDSLINE MED/97244224; Monte S; Fenwick JD; Monteiro EF; Department of Genitourinary Medicine, General Infirmary at Leeds,; UK.
Early detection of acute parvovirus B19 infection in HIV disease by DNA dot blot hybridization.: Int J STD AIDS. 1997 Mar;8(3):203-5. Unique Identifier : AIDSLINE MED/97244225; Rodgers CA; Watkins RP; Coker RJ; Department of Genitourinary Medicine, St Mary's NHS Trust; Hospital, London, UK.
Severe CMV sialadenitis in adults is not always an opportunistic infection of AIDS.: Int J STD AIDS. 1997 Mar;8(3):206-7. Unique Identifier : AIDSLINE MED/97244226; Guntinas-Lichius O; Wagner M; Krueger GF; Stennert E; Department of Otorhinolaryngology, University of Cologne,; Germany.
An audit of the problems in management of patients with gonorrhoea.: Int J STD AIDS. 1997 Mar;8(3):208-9. Unique Identifier : AIDSLINE MED/97244227; Singh G; Thomas PD; Blackwell AL; Department of Genitourinary Medicine, Singleton Hospital,; Swansea, UK.
Potential hazards of hydrogen peroxide within closed body cavities [letter]: Int J STD AIDS. 1997 Mar;8(3):210. Unique Identifier : AIDSLINE MED/97244228; Forrer JA; Woods W
Isolation and quantitation of human immunodeficiency virus type 1 (HIV-1) from peritoneal dialysate: implications for infection control [letter]: Perit Dial Int. 1995;15(3):179-80. Unique Identifier : AIDSLINE MED/97211948; Breyer JA; Harbison MA
Potent blood coagulant activity of human semen due to prostasome-bound tissue factor.: Biol Reprod. 1997 Mar;56(3):757-63. Unique Identifier : AIDSLINE MED/97199047; Fernandez JA; Heeb MJ; Radtke KP; Griffin JH; Department of Molecular and Experimental Medicine, Scripps; Research Institute, La Jolla, California 92037, USA.; Human semen contains very potent blood clotting activity; for example, seminal serum diluted up to 10,000-fold significantly decreased the recalcification clotting time of blood plasma. This seminal coagulant activity was dependent on factor X and calcium ions, suggesting the presence of a facto X activator. Immunoblo
Molecular simulation of the folding patterns of the omega-loop (Tyr181 to Tyr188) of HIV-1 reverse transcriptase.: Drug Des Discov. 1996 Dec;14(3):213-23. Unique Identifier : AIDSLINE MED/97169816; Mager PP; Research Group of Pharmacochemistry, Institute of Pharmacology; and Toxicology, The University, Saxony, Germany.; A large, highly hydrophilic and constrained omega-loop was dissected from the allosteric area of HIV-1 reverse transcriptase (segment Tyr181 to Tyr188). The loop contains two amino acids (Asp185, Asp186) of the catalytic aspartyl triad (Asp110, Asp185, Asp186) and two amino acids (Tyr181, Tyr188) of the nonnucleoside
A hydrophilic omega-loop (Tyr181 to Tyr188) in the nonsubstrate binding area of HIV-1 reverse transcriptase.: Drug Des Discov. 1996 Dec;14(3):225-39. Unique Identifier : AIDSLINE MED/97169817; Mager PP; Walther H; Research Group of Pharmacochemistry, Institute of Pharmacology; and Toxicology of The University, Saxony, Germany.; ppm@pharma.phto.uni-leipzig.de; Using the molecular cloud of the HIV-1 reverse transcriptase (RT) as starting point, the peptide backbone of the polymerase subunit was visualized by molecular modelling. Then, the two subregions 98-106 and 179-190 of the allosteric area were isolated . From the latter subregion, the Tyr181 to Tyr188 segment contai
Evidence of a butterfly-like configuration of structurally diverse allosteric inhibitors of the HIV-1 reverse transcriptase.: Drug Des Discov. 1996 Dec;14(3):241-57. Unique Identifier : AIDSLINE MED/97169818; Mager PP; Research Group of Pharmacochemistry, Institute of Pharmacology; and Toxicology, The University, Saxony, Germany.; ppm@pharma.phto.uni-leipzig.de; Although many physicochemical properties of chemically diverse nonnucleoside inhibitors of HIV-1 reverse transcriptase (NNRTIs) differ, there is a common three-dimensional feature. This shape is a rigid butterfly-like configuration which fits well into a sizable internal cavity of the allosteric area of the enzyme. Th
[Tuberculosis epidemiology in the Cervo (Lugo) health area]: An Med Interna. 1997 Apr;14(4):170-3. Unique Identifier : AIDSLINE MED/97280438; de Pablo Casas M; Pita Carretero J; Villabrille Arias JI; Gordo Perez M; Marino Callejo E; Servicio de Medicina Interna, Hospital Da Costa, Burela, Lugo.; From 1994 to 1995, 80 cases which belonged to 78 patients were diagnosed. The rate was 56.6 cases/100,000 inhabitants/year in 1994 and 51.2 in 1995. The ratio male/female was 2:1 for the two years. Diagnose in hospital was 73% and in health centre 27%. Acid-fast stain and/or positive culture of M. Tuberculosis (MT) an
[Neutropenia in HIV infection]: An Med Interna. 1997 Apr;14(4):199-208. Unique Identifier : AIDSLINE MED/97280446; Moreno Garcia M; Hospital General Penitenciario, Madrid.; The infection by human immunodeficiency virus (HIV) are commonly associated with haematologic abnormalities (anemia, leucopenia and thrombocytopenia). We review the neutropenia. In patients infected with HIV neutropenia is seen in the 8-50% of them, and also have abnormalities in the neutrophil function. Etiology: Dir
[A delay in the care for HIV patients in an area with a low rate of AIDS (letter)]: An Med Interna. 1997 Apr;14(4):214. Unique Identifier : AIDSLINE MED/97280454; Lopez-Gomez M; Mediavilla Garcia JD; Molina Molina F; Mateas Ruiz F
Home parenteral lipids in AIDS: a three-month study.: Nutrition. 1997 Feb;13(2):104-9. Unique Identifier : AIDSLINE MED/97260667; Singer P; Levine R; Rothkopf M; Askanazi J; General Intensive Care Unit, Beilinson Medical Center, Petah; Tiqva, Israel.; Parenteral nutrition is a part of the nutritional support regimen of patients with AIDS-associated wasting syndrome and gastrointestinal dysfunction. The cholesterol (CHOL) level in human immunodeficiency virus (HIV) membrane is very high, and recent lipid formulations with high phospholipid (PL) content have demonstr
Self-assembly of cyclic peptides on a dendrimer: multiple cyclic antigen peptides.: Pept Res. 1996 Nov-Dec;9(6):290-6. Unique Identifier : AIDSLINE MED/97200487; Spetzler JC; Tam JP; Vanderbilt University, Nashville, TN, USA.; Multiple cyclic antigen peptides (McAPs) are dendrimers that have branched, multiple closed-chain architectures. We describe an approach for their stepwise, solid-phase synthesis that permits a self-assembly of cyclization reactions of a McAP with four copies of cyclic peptides in solution after their cleavage from th
Effective use of free thiols as scavengers for HF cocktails to deprotect bromo- and chloroacetylated synthetic peptides.: Pept Res. 1996 Nov-Dec;9(6):305-7. Unique Identifier : AIDSLINE MED/97200489; Ivanov BB; Robey FA; National Institute of Dental Research, NIH, Bethesda, MD, USA.; A variety of thiol-containing compounds, in combination with m-cresol, were tested as scavengers in hydrogen fluoride (HF) cocktails that are used to deprotect haloacetylated peptidyl resins. Our results indicate that brome and chloroacetyl moieties on a synthetic peptide remain intact following HF treatment when the
HIV antibodies in seafarers, fishermen and in other population groups in the Gdansk Region (1993-1996).: Bull Inst Marit Trop Med Gdynia. 1996;47(1-4):67-72. Unique Identifier : AIDSLINE MED/97255719; Towianska A; Dabrowski J; Rozlucka E; Department of Microbiology, Institute of Maritime and Tropical; Medicine in Gdynia.; In 1993-1996, serological tests for HIV were performed comprising seamen, fishermen, people travelling abroad, drug addicts, patients of National Health Service Hospitals, health workers and other groups of people from the Gdansk Region. HIV-antibodies were determined by means of immunoezymatic method ELISA, using Abb
Brain cell lesions in Borna disease are mediated by T cells.: Arch Virol Suppl. 1993;7:153-8. Unique Identifier : AIDSLINE MED/97300877; Bilzer T; Stitz L; Department of Neuropathology, Heinrich-Heine-Universitat; Dusseldorf, Federal Republic of Germany.; Experimental Borna Disease (BD) in rats is characterized by severe lymphocytic encephalitis and by massive brain cell lesions finally leading to brain atrophy. Treatment of BDV-infected rats with monoclonal antibodies directed against CD4+ and CD8+ T cells could almost completely inhibit the immunopathological reactio
Serological and antigenical findings indicating pestivirus in man.: Arch Virol Suppl. 1993;7:53-62. Unique Identifier : AIDSLINE MED/97300870; Giangaspero M; Vacirca G; Buettner M; Wolf G; Vanopdenbosch E; Muyldermans G; Institute of Special Pathology, Faculty of Veterinary Medicine,; University of Milan, Italy.; An epidemiological survey for pestivirus was undertaken in Zambia and Europe, in view of the recent serological findings obtained by previous studies in Europe with humans. Collected sera were tested for anti-bovine viral diarrhea virus (BVDV) specific antibodies by IIF and Western
Is the clinical course of HIV-1 changing? Cohort study.: BMJ. 1997 Apr 26;314(7089):1232-7. Unique Identifier : AIDSLINE MED/97298610; Sinicco A; Fora R; Raiteri R; Sciandra M; Bechis G; Calvo MM; Gioannini P; Department of Medical and Surgical Sciences, University of Turin,; Amedeo di Savoia Hospital, Italy.; OBJECTIVE: To assess whether the clinical course of HIV infection has changed from 1985 to 1995. DESIGN: Cohort Study. SETTING: Infectious disease clinic. SUBJECTS: 285 patients recruited from September 1985 to January 1995 with
HIV transmitted by bone graft [news]: BMJ. 1997 May 3;314(7090):1300. Unique Identifier : AIDSLINE MED/97302102; Karcher HL
Socioeconomic determinants of health: community marginalisation and the diffusion of disease and disorder in the United States.: BMJ. 1997 May 3;314(7090):1341-5. Unique Identifier : AIDSLINE MED/97302113; Wallace R; Wallace D; New York Psychiatric Institute, New York 10032, USA.; rdwall@ix.netcom.com; This article describes the cascading diffusion of inner city problems of disease and disorder in the United States--from the huge marginalised inner city communities of the largest municipalities, first along national travel routes to smaller cities, and then from central cities into surrounding more affluent suburb
Antenatal HIV testing: what now? [editorial]: BMJ. 1997 May 17;314(7092):1429-30. Unique Identifier : AIDSLINE MED/97310386; Noone A; Goldberg D
Direct HIV testing of donated blood is inevitable [news]: BMJ. 1997 May 17;314(7092):1437. Unique Identifier : AIDSLINE MED/97310390; Legge A
Molecular investigation into outbreak of HIV in a Scottish prison.: BMJ. 1997 May 17;314(7092):1446-50. Unique Identifier : AIDSLINE MED/97310393; Yirrell DL; Robertson P; Goldberg DJ; McMenamin J; Cameron S; Leigh Brown AJ; Centre for HIV Research, Institute of Cell, Animal and Population; Biology, University of Edinburgh.; OBJECTIVES: To support already established epidemiological links between inmates of Glenochil prison positive for HIV infection by using molecular techniques and thus provide evidence of the extent of acquisition during a recent outbreak of the disease resulting from needle sharing. To identify possible sources of the
Gene therapy for hematopoietic and immune disorders.: Bone Marrow Transplant. 1996 Dec;18 Suppl 3:S55-8. Unique Identifier : AIDSLINE MED/97126495; Kohn DB; Division of Research Immunology/Bone Marrow Transplantation,; Childrens Hospital Los Angeles, CA 90027 USA.; Gene therapy is a novel approach under investigation for the treatment of genetic diseases, cancer and AIDS. Hematopoietic stem cells would be the target cell for correction of hemoglobinopathies, immune deficiencies and lysosomal storage diseases. Retroviral vectors derived from murine leukemia viruses have been used
In vitro cellular responses from sheep draining lymph node cells after subcutaneous inoculation with Salmonella abortusovis.: Vet Res. 1997;28(2):165-78. Unique Identifier : AIDSLINE MED/97267072; Doucet F; Bernard S; Equipe genetique et immunite, laboratoire de pathologie; infectieuse et immunologie, Institut national de la recherche; agronomique, Centre de Tours, Nouzilly, France.; Salmonella abortusovis infection leads to ovine abortion. The basis for immunity against this infection is unknown. Immune responses were studied from prescapular lymph node (PSLN) cells of sheep infected with either a subcutaneous inoculation of virulent (15/5) or a vaccine (Rv6) strain and compared with those of uni
Acute acalculous cholecystitis with a decrease in CD4/CD8 ratio.: J Gastroenterol. 1997 Apr;32(2):268-72. Unique Identifier : AIDSLINE MED/97239519; Ikeda S; Kimura W; Futakawa N; Komuro Y; Ono M; Zhao B; Muto T; First Department of Surgery, University of Tokyo, Japan.; Acute acalculous cholecystitis (AAC) usually occurs in the elderly and in those with severe pre-existing pathological conditions. However, there have recently been reports of AAC in relatively young immunosuppressed patients, such as those with acquired immunodeficiency syndrome (AIDS). We report here a 27-year-old wo
Determination of an in vivo metabolite of a human immunodeficiency virus protease-inhibitor in human plasma by high-performance liquid chromatography with tandem mass spectrometry.: J Chromatogr A. 1997 Feb 21;762(1-2):311-9. Unique Identifier : AIDSLINE MED/97253549; Woolf E; Haddix HM; Matuszewski B; Merck Research Laboratories, Department of Drug Metabolism, PA; 19486, USA.; A method for the determination of a metabolic of the human immunodeficiency virus protease inhibitor indinavir , in human plasma is described. Isolation of the analyte and the internal standard from plasma was achieved via liquid-liquid extraction with
Epstein-Barr virus-infected lymphocytes in non-neoplastic lymph nodes of patients infected with human immunodeficiency virus.: Pathol Int. 1997 Apr;47(4):217-21. Unique Identifier : AIDSLINE MED/97256371; Zheng H; Mori S; Department of Pathology, The Institute of Medical Science, The; University of Tokyo, Minato-ku, Japan.; Non-Hodgkin s lymphomas occurring in AIDS patients (AIDS-NHL) are known to be highly associated with Epstein-Barr virus (EBV). However, there have been no previous detailed studies of the distribution of EBV-infected non-neoplastic lymphoblasts, which may act as precursors of AIDS-NHL. In the present study, an attempt
Human immunodeficiency virus infection in patients older than 50 years. A survey of primary care physicians' beliefs, practices, and knowledge.: Arch Fam Med. 1997 May-Jun;6(3):289-94. Unique Identifier : AIDSLINE MED/97305083; Skiest DJ; Keiser P; Division of Infectious Diseases, University of Texas Southwestern; Medical Center, Dallas, USA. skiest@utsw.swmed.edu; To assess primary care physicians attitudes, knowledge, and practices with respect to the human immunodeficiency virus (HIV) in older patients, a prospective survey of a representative cohort of primary care physicians was conducted in Dallas County, Texas, a large metropolitan area. Three hundred thirty primary care
Intracerebral administration of Mycoplasma fermentans produces sickness behavior: role of prostaglandins.: Brain Res. 1997 Feb 21;749(1):71-81. Unique Identifier : AIDSLINE MED/97224048; Yirmiya R; Barak O; Avitsur R; Gallily R; Weidenfeld J; Department of Psychology, The Hebrew University of Jerusalem,; Mount Scopus, Israel.; Mycoplasmas are small microorganisms, which cause various diseases in animals and in humans, activate the immune system, and induce the release of various cytokines. Some of the effects of mycoplasmas are mediated by the CNS. Moreover, Mycoplasma fermentans (MF) has recently been found in the brain, as well as other t
Compliance with universal precautions among physicians.: J Occup Environ Med. 1997 Feb;39(2):130-7. Unique Identifier : AIDSLINE MED/97200384; Michalsen A; Delclos GL; Felknor SA; Davidson AL; Johnson PC; Vesley D; Murphy LR; Kelen GD; Gershon RR; Southwest Center for Occupational and Environmental Health,; University of Texas School of Public Health, Houston 77225-0186,; USA.; This study characterized and assessed self-reported levels of compliance with universal precautions (UP) among hospital-based physicians, and determined significant factors associated with both compliance and noncompliance. The physicians (n = 322) were a subgroup of a larger study population of hospital-based health
Blind T-cell homeostasis and the CD4/CD8 ratio in the thymus and peripheral blood.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 15;14(5):387-98. Unique Identifier : AIDSLINE MED/97314070; Mehr R; Perelson AS; Department of Molecular Biology, Princeton University, New; Jersey, USA.; We present a model of the dynamics of CD4 and CD8 T-cell subsets in the thymus and peripheral blood and use it to study the blind homeostasis hypothesis, which states that the total T-cell population in the periphery is subject to regulation rather than regulation of the CD4 or CD8 subsets individually. Our model reco
Zidovudine potentiates local and systemic inflammatory responses in the rat.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 15;14(5):399-407. Unique Identifier : AIDSLINE MED/97314071; Raymond P; Blais C Jr; Decarie A; Morais R; Adam A; Faculte de Pharmacie, Universite de Montreal, Quebec, Canada.; The effect of chronic treatment with zidovudine ( AZT ) on the inflammatory response was examined in the rat. AZT was administered orally for 36 days. On day 35, inflammation was induced by hindpaw injection of 1% carrageenan lambda. Paw edema over a 24
Correlation between plasma HIV-1 RNA levels and the rate of immunologic decline.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 15;14(5):408-14. Unique Identifier : AIDSLINE MED/97314072; Iuliano R; Forastieri G; Brizzi M; Mecocci L; Mazzotta F; Ceccherini-Nelli L; Department of Biomedicine, University of Pisa, Italy.; To determine the influence of HIV-1 replication on immunologic decline and clinical outcome, we quantified the HIV-1 plasma viral load in 20 patients at different times over a mean period of 10.8 months. Quantitation was performed by branched DNA signal amplification (bDNA) and p24 antigenemia. Immunologic status was
Anal cytology as a screening tool for anal squamous intraepithelial lesions.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 15;14(5):415-22. Unique Identifier : AIDSLINE MED/97314073; Palefsky JM; Holly EA; Hogeboom CJ; Berry JM; Jay N; Darragh TM; Department of Laboratory Medicine, University of California, San; Francisco, USA.; Anal squamous intraepithelial lesions (ASIL) are common in homosexual and bisexual men, and high-grade ASIL (HSIL) in particular may represent an anal cancer precursor. Cervical cytology is a useful screening tool for detection of cervical HSIL to prevent cervical cancer. To assess anal cytology as a screening tool fo
Definition and diagnosis of cytomegalovirus colitis in patients infected by human immunodeficiency virus.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 15;14(5):423-9. Unique Identifier : AIDSLINE MED/97314074; Beaugerie L; Cywiner-Golenzer C; Monfort L; Girard PM; Carbonnel F; Ngo Y; Cosnes J; Rozenbaum W; Nicolas JC; Chatelet FP; Gendre JP; Department of Gastroenterology, Hopital Rothschild, Paris,; France.; The definition and routine diagnosis of cytomegalovirus ( CMV ) colitis in patients infected by human immunodeficiency virus (HIV) are controversial. In 100 consecutive HIV-infected patients who underwent colonoscopy for the in
Induction of granulocyte colony-stimulating factor by acute febrile infection but not by neutropenia in HIV-seropositive individuals.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 15;14(5):430-4. Unique Identifier : AIDSLINE MED/97314075; Mauss S; Steinmetz HT; Willers R; Manegold C; Kochanek M; Haussinger D; Jablonowski H; Department of Gastroenterology, Hepatology, and Infectious; Diseases, Heinrich Heine University, Dusseldorf, Germany.; The objective of this study was to assess endogenous granulocyte colony-stimulating factor (G-CSF) serum levels in HIV-seropositive individuals with persistent neutropenia or acute febrile infection. Serum levels of G-CSF were measured by enzyme-linked immunoabsorbent assay. HIV-seropositive subjects (n = 28) with afe
Associations of age, immunosuppression, and AIDS among homosexual men in the Tricontinental Seroconverter Study.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 15;14(5):435-41. Unique Identifier : AIDSLINE MED/97314076; Veugelers PJ; Strathdee SA; Kaldor JM; Shafer KA; Moss AR; Schechter MT; Schellekens PT; Coutinho RA; van Griensven GJ; Municipal Health Service, Department of Public Health, Amsterdam,; The Netherlands.; To characterize the associations of age, immunosuppression, and AIDS outcomes, we evaluated serial measures of CD4+ lymphocytes from 376 homosexual men with documented dates of HIV-1 seroconversion registered in the Tricontinental Seroconverter Study. Using regression models and adjusting for variation within individu
Morbidity and mortality in European children vertically infected by HIV-1. The French Pediatric HIV Infection Study Group and European Collaborative Study.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 15;14(5):442-50. Unique Identifier : AIDSLINE MED/97314077; Blanche S; Newell ML; Mayaux MJ; Dunn DT; Teglas JP; Rouzioux C; Peckham CS; Unite d'Immunologie Hematologie Pediatriques, Hopital Necker,; Inserm U292, Paris, France.; Based on 392 infected children enrolled in two European prospective studies of infants born to HIV-infected women, with similar standard protocols, HIV disease progression in the first 6 years of life is described, using the 1994 CDC paediatric HIV classification. Most children had developed minor (A) or moderately se
Effect of smoking on the clinical progression of HIV-1 infection.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 15;14(5):451-8. Unique Identifier : AIDSLINE MED/97314078; Galai N; Park LP; Wesch J; Visscher B; Riddler S; Margolick JB; Department of Epidemiology, Johns Hopkins University School of; Public Health, Baltimore, MD 21205, USA.; Cigarette smoking as a risk factor in progression of HIV-1 disease was investigated in the Multicenter AIDS Cohort Study of homosexual men. Longitudinal data for T-cell subsets, HIV-related clinical symptoms, smoking behavior, and AIDS medication use were collected semiannually from 2,499 HIV-1-seropositive men for up
Survival after AIDS-defining events in patients with < 200 lymphocytes CD4+ x 10(6)/L who are toxoplasmosis antibody positive. ANRS 005/ACTG 154 Trial Group.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 15;14(5):459-64. Unique Identifier : AIDSLINE MED/97314079; Pueyo S; Salmi LR; Chene G; Leport C; Morlat P; Dequae L; Gregoire V; Hafner R; Vilde JL; Luft BJ; Aubertin J; Salamon R; Department d'Informatique Medicale, Universite Victor Segalen; Bordeaux 2, France.; The objective of this study was to assess whether patients with CD4+ cell counts
Trends in heterosexually acquired AIDS in the United States, 1988 through 1995.: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 15;14(5):465-74. Unique Identifier : AIDSLINE MED/97314080; Neal JJ; Fleming PL; Green TA; Ward JW; Council of State and Territorial Epidemiologists, Atlanta, GA; 30341, USA.; We used national AIDS surveillance data to characterize trends in the numbers and proportions of heterosexually acquired AIDS cases diagnosed from January 1988 through December 1995 among adults and adolescents. We adjusted for expansion of the 1993 AIDS surveillance case definition and for delays in reporting, and we
Oral sex and HIV transmission [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 15;14(5):475. Unique Identifier : AIDSLINE MED/97314081; Berrey MM; Shea T
Immune reactivity of HTLV-IIa-infected Kayapo Indians with HTLV-IIb extended Tax epitope [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 15;14(5):476-7. Unique Identifier : AIDSLINE MED/97314082; Lal RB; Pardi D; Switzer W; Segurado A; Black F
Kaposi's sarcoma: is the hunt for the culprit over now?: J Mol Med. 1997 Jan;75(1):28-34. Unique Identifier : AIDSLINE MED/97172297; Schatz O; Bogner JR; Goebel FD; MedizinischePoliklinik, Klinikum Innenstadt, Ludwig-Maximilians; Universitat Munchen, Munich, Germany.; Patients suffering from the acquired immune deficiency syndrome (AIDS) have a 20000-fold increased risk of developing a severe form of Kaposi s sarcoma (KS), a previously rare malignancy involving sharply defined nodular lesions of the skin and/or oral mucosa. Epidemiological evidence has long suggested that an infect
[Isolation, culture and characterization of astrocytes from adult monkey brains]: C R Seances Soc Biol Fil. 1996;190(5-6):595-601. Unique Identifier : AIDSLINE MED/97228679; Guillemin G; Boussin F; Dormont D; Service de Neurovirologie, CEA, DSV/DRMSSA/IPSC,; Fontenay-aux-Roses, France.; We have developed protocols for the isolation, the culture and the immunocytochemical characterization of astrocytes from simian adult brains. We have obtained pure astrocyte cultures without contamination with other cells present in brain. No microglial cells, oligodendrocytes, neurons or fibroblasts were detected by
HLA class II antigens and T lymphocytes in human nasal epithelial cells. Modulation of the HLA class II gene transcripts by gamma interferon.: Clin Exp Allergy. 1997 Mar;27(3):306-14. Unique Identifier : AIDSLINE MED/97243816; Wang D; Levasseur-Acker GM; Jankowski R; Kanny G; Moneret-Vautrin DA; Charron D; Lockhart A; Swierczewski E; Laboratoir de Physiologie Respiratoire Universites Paris V,; Nancy, France.; BACKGROUND: Nasal polyps are characterized by a proliferation of the epithelial layer of the mucosa, cellular infiltrates and other pathological changes; however the mechanisms involved in polyp pathogenesis remain largely unclear. OBJECTIVES: We have taken two different approaches to study the cellular events involve
Immune effector cells induced by complete Freund's adjuvant exert an inhibitory effect on antigen-specific type 2 T helper responses.: Clin Exp Allergy. 1997 Mar;27(3):315-24. Unique Identifier : AIDSLINE MED/97243817; Chuang YH; Chiang BL; Chou CC; Hsieh KH; Graduate Institute of Immunology, College of Medicine, National; Taiwan University, Taipei, Republic of China.; BACKGROUND: It has been well documented that environmental factors such as antigenpresenting cells and related cytokines could affect the development of T helper cells. OBJECTIVE: The purpose of this study is to investigate the effect of different adjuvants on T cell development. METHODS: Ovalbumin (OVA) combined with
Purified herpes simplex thymidine kinase Retrovector particles. I. In vitro characterization, in situ transduction efficiency, and histopathological analyses of gene therapy-treated brain tumors.: Cancer Gene Ther. 1997 Mar-Apr;4(2):118-28. Unique Identifier : AIDSLINE MED/97234931; Kruse CA; Roper MD; Kleinschmidt-DeMasters BK; Banuelos SJ; Smiley WR; Robbins JM; Burrows FJ; University of Colorado Health Services Center, Department of; Immunology, Denver 80262, USA.; Replication-defective, highly purified retroviral vectors (Retrovector), at titers of 10(8) colony forming units/mL, were prepared that conferred either beta-galactosidase or herpes simplex thymidine kinase (HSV-TK) activity. 9L gliosarcoma cells, transduced efficiently in vitro, were highly sensitive to ganciclovir (
Cellular immunity aspects in elderly subjects with Paget's disease of bone.: Calcif Tissue Int. 1997 May;60(5):410-4. Unique Identifier : AIDSLINE MED/97277276; Natale VM; Filho WJ; Duarte AJS; Laboratorio de Imunogenetica e Transplante Experimental (LIM; 56), Servico de Clinica Geral do Hospital das Clinicas da; Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP),; Av. Dr. Arnaldo, 455, CEP: 01246-903, Sao Paulo, Brazil.; The etiology and pathophysiology of Paget s disease of bone are not yet entirely defined. There is evidence suggesting the participation of the immune system in the pathophysiology of this disease. Hence, we examined T cell mitogenic proliferation, NK cell activity, T cell subsets, interleukin-1 (IL-1), and interleuki
Matrix metalloproteinases-1, -3 and -8 and myeloperoxidase in saliva of patients with human immunodeficiency virus infection.: Oral Dis. 1996 Dec;2(4):263-71. Unique Identifier : AIDSLINE MED/97315435; Mellanen L; Ingman T; Lahdevirta J; Lauhio A; Ainamo A; Konttinen YT; Sukura A; Salo T; Sorsa T; Department of Periodontology, University of Helsinki, Finland.; OBJECTIVE: Human immunodeficiency virus (HIV)-seropositive patients have frequently severe gingival inflammation and/or attachment loss. In addition many infectious diseases affect their periodontium with varying clinical manifestations. Matrix metalloproteinases seem to play a key role in physiological periodontal re
Apoptosis-associated proteins in oral hairy leukoplakia.: Oral Dis. 1996 Dec;2(4):279-84. Unique Identifier : AIDSLINE MED/97315437; Chrysomali E; Greenspan JS; Dekker N; Greenspan D; Regezi JA; Department of Stomatology, School of Dentistry, University of; California, San Francisco, USA.; OBJECTIVE: To test the hypothesis that the anti-apoptotic ability of Epstein-Barr virus (EBV) may result in altered expression of apoptosis-associated proteins in oral hairy leukoplakia (HL), we evaluated HL tissue and normal epithelium for these proteins by immunohistochemistry. MATERIALS AND METHODS: Twenty formalin
CDA approves HIV testing guidelines [news]: J Can Dent Assoc. 1997 May;63(5):332. Unique Identifier : AIDSLINE MED/97314486
U.S. court rules refusal to have children an HIV disability [news]: J Can Dent Assoc. 1997 May;63(5):333-4. Unique Identifier : AIDSLINE MED/97314488
Beta-human choriogonadotropin therapy and HIV-related Kaposi's sarcoma.: Eur J Med Res. 1997 Apr 21;2(4):155-8. Unique Identifier : AIDSLINE MED/97265493; Witzke O; Hense J; Reinhardt W; Reiner C; Hoermann R; Philipp T; Universitaetsklinikum Essen, Medizinische Klinik, Abteilung fuer; Nieren- und Hochdruckkrankheiten, Hufelandstr. 55, Essen D-45147,; Germany.; Recently, two clinical trials demonstrated an antitumour effect of systemic high-dose beta-hCG therapy and of different regimens of local beta-hCG injections in AIDS-related Kaposi s sarcoma. We report the efficacy and safety of subcutaneous beta-hCG treatment (low-dose (2500-25000 IU/day) or high dose (25000-100000 I
Cavitary cryptococcoma of the lungs and meningitis by Cryptococcus neoformans in a patient with AIDS.: Eur J Med Res. 1997 Apr 21;2(4):173-6. Unique Identifier : AIDSLINE MED/97265497; Schubert S; Lebeau A; Zell R; Goebel F; Max von Pettenkofer-Institut fuer Hygiene und Mikrobiologie,; Pettenkoferstr. 9a, Munich, D-80336, Germany.; schubert@m3401.mpk.med.uni-muenchen.de; We report on a 39-year-old AIDS patient who presented a generalized cryptococcal disease with involvement of the lungs and central nervous system. Although the initial symptoms were mild and uncharacteristic, the radiological finding of cavernous destructions of the lungs (cryptococcoma) was detectable. The patient re
International expenditure projections for pharmacotherapeutic advances in the treatment of HIV/AIDS.: Clin Ther. 1997 Jan-Feb;19(1):86-95; discussion 84-5. Unique Identifier : AIDSLINE MED/97237233; Sclar DA; Robison LM; Skaer TL; Terriff CM; Garrison MW; College of Pharmacy, Washington State University, Pullman, USA.
Protease inhibitors: a therapeutic breakthrough for the treatment of patients with human immunodeficiency virus.: Clin Ther. 1997 Mar-Apr;19(2):187-214. Unique Identifier : AIDSLINE MED/97297092; Lewis JS 2nd; Terriff CM; Coulston DR; Garrison MW; Washington State University, College of Pharmacy, Spokane, USA.; As one of the largest growing classes of antiretroviral drugs, protease inhibitors are promising agents for the management of patients infected with the human immunodeficiency virus (HIV). We reviewed the literature and compared efficacy, dosing, side effects, and d
An HIV/AIDS prevention project for Mexican homosexual men: an empowerment approach.: Health Educ Behav. 1997 Apr;24(2):177-90. Unique Identifier : AIDSLINE MED/97233466; Zimmerman MA; Ramirez-Valles J; Suarez E; de la Rosa G; Castro MA; University of Michigan School of Public Health, Ann Arbor; 48109-2029, USA. marcz@umich.edu; In this intervention, participants design and implement an HIV/AIDS prevention project for Mexican homosexual men. The intervention is consistent with, and contributes to, empowerment theory because it enhances collective action, provides opportunities to develop knowledge and skills, creates needed resources, and inc
The role of germs and viruses in children's theories of AIDS (or, AIDS are not Band-Aids).: Health Educ Behav. 1997 Apr;24(2):191-200. Unique Identifier : AIDSLINE MED/97233467; Sigelman CK; Alfeld-Liro C; Lewin CB; Derenowski EB; Woods T; George Washington University, Washington, DC 20052, USA.; carol@gwis2.circ.gwu.edu; The development of knowledge of germs and viruses in relation to AIDS and flu was examined in a predominantly Mexican American sample of children aged 8-9, 10-11, and 12-13. Children progressed with age from identifying the disease agent for these diseases as a nondescript germ or something other than a germ to implic
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells.: Cell. 1997 May 16;89(4):587-96. Unique Identifier : AIDSLINE MED/97304387; Zheng W; Flavell RA; Howard Hughes Medical Institute, Yale University School of; Medicine, New Haven, Connecticut 06520-8011, USA.; CD4 T cells potentiate the inflammatory or humoral immune response through the action of Th1 and Th2 cells, respectively. The molecular basis of the differentiation of these cells from naive T cell precursors is, however, unclear. We found that GATA-3 was selectively expressed in Th2 cells. GATA-3 is expressed at a hi
Adoptive immunotherapy as an in vivo model to explore antitumor mechanisms induced by a recombinant anticancer vaccine.: J Immunother. 1997 Jan;20(1):48-59. Unique Identifier : AIDSLINE MED/97256082; Abrams SI; Hodge JW; McLaughlin JP; Steinberg SM; Kantor JA; Schlom J; Laboratory of Tumor Immunology and Biology, National Cancer; Institute, National Institutes of Health, Bethesda, Maryland; 20892-1750, USA.; We have described previously the construction, generation, and in vivo biologic consequences of a recombinant vaccinia virus containing the human CEA gene (rV-CEA) in an experimental murine colon carcinoma model. Immunization of C57BL/6 mice with rV-CEA led to antigen-specific inhibition of tumor growth in both prophy
Expansion of restricted cellular immune responses to HIV-1 envelope by vaccination: IL-7 and IL-12 differentially augment cellular proliferative responses to HIV-1.: Clin Exp Immunol. 1997 May;108(2):243-50. Unique Identifier : AIDSLINE MED/97301714; Kim JH; Loveland JE; Sitz KV; Ratto Kim S; Mclinden RJ; Tencer K; Davis K; Burke DS; Boswell RN; Redfield RR; Birx DL; Division of Retrovirology, Walter Reed Army Institute of; Research, Rockville, MD, USA.; The failure of immune effector mechanisms to control HIV-1 infection has important consequences for the human host. In a randomized cohort of HIV-infected patients, there was striking in vitro restriction of the proliferative response to HIV-1 envelope protein (Env), gp160; only 34% of patients recognized Env. Therape
High serum level of soluble CD30 in acute primary HIV-1 infection.: Clin Exp Immunol. 1997 May;108(2):251-3. Unique Identifier : AIDSLINE MED/97301715; Pizzolo G; Vinante F; Nadali G; Krampera M; Morosato L; Chilosi M; Raiteri R; Sinicco A; Department of Haematology, Policlinico Borgo Roma, Verona; University School of Medicine, Italy.; CD30 has been suggested to play a role in HIV infection. In this study the serum concentration of soluble CD30 (sCD30) was determined by an ELISA essay on samples collected from patients with acute primary HIV-1 infection during the acute phase (n = 17) and after seroconversion (n = 13). sCD30 during acute infection w
Characterization of HIV-related periodontitis in AIDS patients: HIV-infected macrophage exudate in gingival crevicular fluid as a hallmark of distinctive etiology.: Clin Exp Immunol. 1997 May;108(2):254-9. Unique Identifier : AIDSLINE MED/97301716; Suzuki T; Tai H; Yoshie H; Jeannel D; Fournier S; Dupont B; De The G; Hara K; Department of Periodontology, Niigata University School of; Dentistry, Japan.; In an attempt to clarify the immunobiological events featuring periodontitis lesions of AIDS patients in the late stage of the disease, peripheral blood (PB) and gingival crevicular fluid (GCF) leucocytes from periodontitis lesions of 23 late-stage AIDS patients were analysed by three-colour flow cytometry for detecti
Specific activation of resting T cells against tumour cells by bispecific antibodies and CD28-mediated costimulation is accompanied by Th1 differentiation and recruitment of MHC-independent cytotoxicity.: Clin Exp Immunol. 1997 May;108(2):352-7. Unique Identifier : AIDSLINE MED/97301732; Hombach A; Tillmann T; Jensen M; Heuser C; Sircar R; Diehl V; Kruis W; Pohl C; Klinik I fur Innere Medizin der Universitat zu Koln, Germany.; Specific activation of resting lymphocytes for tumour targeting can be achieved by bispecific monoclonal antibodies (bi-MoAbs) with specificity for tumour antigens and T cell-activating antigens in combination with a costimulatory anti-CD28 antibody. In this study we focus on the immunomodulatory function of an anti-C
Preclinical primary central nervous system lymphoma.: Clin Neuropathol. 1997 Mar-Apr;16(2):85-9. Unique Identifier : AIDSLINE MED/97255779; Sawabe M; Esaki Y; Tsubokou Y; Takubo K; Yamada S; Mizutani T; Kanazawa A; Department of Pathology, Tokyo Metropolitan Geriatric Hospital,; Japan.; We report an autopsy case of preclinical primary central nervous system (CNS) lymphoma. The case was an 89-year-old female who died of rupture of a thoracic aortic aneurysm. No neurological abnormalities were found throughout our clinical observation. Serum anti-human T-cell leukemia virus type 1 and anti-human immuno
Perioperative collapse: prevalence of latex allergy in patients sensitive to anaesthetic agents.: Contact Dermatitis. 1997 Jan;36(1):47-50. Unique Identifier : AIDSLINE MED/97187235; Tan BB; Lear JT; Watts J; Jones P; English JS; Department of Dermatology, North Staffordshire Hospital, Keele,; UK.; The evidence in the literature suggests that the prevalence of latex allergy in the general population is approximately 1%. With increasing awareness of transmission of HIV and other infections such as hepatitis B, the use of latex gloves and condoms has escalated in recent years. As cheaper latex gloves of variable a
Buschke-Lowenstein tumor and immunity.: Cutis. 1997 Mar;59(3):119-22. Unique Identifier : AIDSLINE MED/97225176; Gonzalez-Lopez A; Esquivias JI; Miranda-Romero A; Massa CF; Tejerina JA; Blasco MJ; Department of Dermatology, University Hospital of Valladolid,; Spain.; We report the case of an alcoholic patient, 41 years old, with negative results of serologic tests for human immunodeficiency virus (HIV) with a perianal Buschke-Lowenstein tumor present for eight years and exceptionally large. The patient s cell-mediated immunity was evaluated by two functional tests: the Multitest I
Cutaneous aspergillosis.: Cutis. 1997 Mar;59(3):138-40. Unique Identifier : AIDSLINE MED/97225180; Smith WF; Wallace MR; Department of Dermatology, Naval Medical Center, San Diego,; California 92134-5000, USA.; The authors present a patient with advanced acquired immunodeficiency syndrome who developed a cutaneous lesion under the transparent dressing of a venous catheter. Histologic examination of the lesion revealed suppurative granulomatous inflammation in the dermis with numerous branching hyphae within the follicular in
Antitumor, immunomodulatory and anti-HIV effect of mangiferin, a naturally occurring glucosylxanthone.: Chemotherapy. 1996 Nov-Dec;42(6):443-51. Unique Identifier : AIDSLINE MED/97116491; Guha S; Ghosal S; Chattopadhyay U; Department of Tumor Immunobiology, Chittaranjan National Cancer; Institute, Calcutta, India.; Mangiferin, a C-glucosylxanthone (1,3,6,7-tetrahydroxyxanthone-C2-beta-D-glucoside) purified from plant sources was shown to have in vivo growth-inhibitory activity against ascitic fibrosarcoma in Swiss mice. Following in vivo or in vitro treatment, it also enhanced tumor cell cytotoxicity of the splenic cells and per
IDDM in an adolescent patient with common variable immunodeficiency [letter]: Diabetes Care. 1997 Apr;20(4):677-8. Unique Identifier : AIDSLINE MED/97251323; Metin A; Tezcan I; Ozyurek H
[Endocrine disorders and hormonal therapy in HIV infections]: Dtsch Med Wochenschr. 1997 May 9;122(19):621-6. Unique Identifier : AIDSLINE MED/97317536; Hofbauer LC; Heufelder AE; Division of Endocrinology, Mayo Clinic, Rochester, USA.
Circulating immune complexes in human tuberculosis sera: demonstration of specific antibodies against Mycobacterium tuberculosis glycolipid (DAT, PGLTb1, LOS) antigens in isolated circulating immune complexes.: Eur J Clin Invest. 1997 Feb;27(2):128-34. Unique Identifier : AIDSLINE MED/97214941; Simonney N; Molina JM; Molimard M; Oksenhendler E; Lagrange PH; Service de Microbiologie, Hopital Saint-Louis, Paris, France.; An enzyme-linked immunosorbent assay (ELISA) for IgG using three glycolipid antigens from Mycobacterium tuberculosis in 65 tuberculosis (TB) patients and 50 healthy control subjects was performed. The circulating immune complexes (CICs) were isolated by precipitation with polyethylene glycol 6000 (PEG). This method as
Endoscopic features of gastroduodenal cryptococcosis in AIDS.: Gastrointest Endosc. 1997 Mar;45(3):315-7. Unique Identifier : AIDSLINE MED/97242849; Chalasani N; Wilcox CM; Hunter HT; Schwartz DA; Department of Medicine, Emory University, School of Medicine,; Atlanta, Georgia, USA.
Endoscopic appearance of Mycobacterium genavense [letter]: Gastrointest Endosc. 1997 Mar;45(3):334. Unique Identifier : AIDSLINE MED/97242856; Dumonceau JM
The ethical foundations of a duty to treat HIV-positive patients.: Gen Dent. 1997 Jan-Feb;45(1):14-16, 18, 20 passim. Unique Identifier : AIDSLINE MED/97315400; Chiodo GT; Tolle SW; Center for Ethics in Health Care, Oregon Health Sciences; University, Portland 97201, USA.; Unfortunately, those who commit the most egregious acts of HIV-related discrimination may not be motivated to change either by fines and sanctions, or by educational programs. Perhaps the best solution to dealing with the small, but significant, number of health care providers who discriminate against HIV-positive pat
Confidentiality versus disclosure of a patient's infectious status.: Gen Dent. 1997 Jan-Feb;45(1):78-80. Unique Identifier : AIDSLINE MED/97315411; Nicol TE; Patients in health care settings have a legal and moral right to privacy, which includes confidentiality of all information related to the patient or gathered by the patient s health care team. Even so, the right to privacy is not total. Under certain circumstances, that right must yield to a state s fundamental right
Modulation of immune dysfunction during murine leukaemia retrovirus infection of old mice by dehydroepiandrosterone sulphate (DHEAS).: Immunology. 1997 Mar;90(3):344-9. Unique Identifier : AIDSLINE MED/97300619; Araghi-Niknam M; Liang B; Zhang Z; Ardestani SK; Watson RR; Arizona Prevention Center, University of Arizona, Tucson 85724,; USA. rwatson@ccit.arizona.edu; Ageing, leukaemia and acquired immune deficiency syndrome (AIDS) are conditions with dysregulated cytokine production. As dehydroepiandrosterone sulphate (DHEAS) restored normal cytokine production in old mice its effects on retrovirally infected old mice were investigated. Retrovirus infection and ageing-induced immu
Nitric oxide increased interleukin-4 expression in T lymphocytes.: Immunology. 1997 Mar;90(3):364-9. Unique Identifier : AIDSLINE MED/97300622; Chang RH; Feng MH; Liu WH; Lai MZ; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan,; China.; Nitric oxide (NO) is a regulator of many biological functions including T helper 1 (Th1)/T helper 2 cells balance. It has been demonstrated that NO inhibits the secretion of interleukin-2 ( IL-2 ) and interferon-gamma on Th1 cells. Here we showed that, in addition to the
Mouse hepatitis viral infection induces an extrathymic differentiation of the specific intrahepatic alpha beta-TCRintermediate LFA-1high T-cell population.: Immunology. 1997 Mar;90(3):402-11. Unique Identifier : AIDSLINE MED/97300628; Lamontagne L; Massicotte E; Page C; Departement des Sciences Biologiques, Universite du Quebec a; Montreal, Canada.; Mouse hepatitis virus type 3 (MHV3), a coronavirus, is an excellent model for the study of thymic and extrathymic T-cell subpopulation disorders induced during viral hepatitis. It was recently reported that, in addition to the intrathymic T-cell differentiation pathway, an extrathymic differentiation pathway of alpha
Suppression of murine thyroiditis via blockade of the CD40-CD40L interaction.: Immunology. 1997 Mar;90(3):421-6. Unique Identifier : AIDSLINE MED/97300630; Carayanniotis G; Masters SR; Noelle RJ; Faculty of Medicine, Memorial University of Newfoundland, St; John's, Canada.; The CD40 ligand (gp39) is transiently expressed on activated CD4+ T cells and mediates cognate helper function by interacting with CD40 on B cells. Increasing evidence suggests, however, critical involvement of gp39 not only in antibody-mediated responses but also in the development of effector T cells. Here, we have
Tandem peptide epitopes facilitate CD4-dependent activation of T cell clones.: Immunol Cell Biol. 1997 Apr;75(2):148-53. Unique Identifier : AIDSLINE MED/97261640; Hayball JD; Fidler SJ; Palliser D; Rees AD; Lamb JR; Lake RA; Department of Immunology, St. Mary's Hospital Medical School,; London United Kingdom.; Peptides that consist of two tandemly repeated epitopes joined by a flexible linker have an increased affinity for class II molecules and are more potent at inducing proliferation of T cell clones than monomeric epitopes. The increase in potency of peptides with two epitopes for individual T cell clones is proportiona
TCR beta-independent development of CD4+ CD8+ thymocytes observed in a strain of scid mice.: Immunol Cell Biol. 1997 Apr;75(2):154-60. Unique Identifier : AIDSLINE MED/97261641; Shibata S; Asano T; Ogura A; Hashimoto N; Hayakawa J; Naiki M; Doi K; Department of Veterinary Science, National Institute of Health,; Tokyo, Japan.; Mice homozygous for severe combined immunodeficiency (scid) mutation usually halt their thymocyte development at the CD4-CD8- double negative (DN) stage due to their inability of TCR gene rearrangement. In this study, we report that SCID-bg mice, which were originally generated by mating CB-17-scid mice with KSN-bg mi
Inhibition of IL-2 production by nitric oxide: a novel self-regulatory mechanism for Th1 cell proliferation.: Immunol Cell Biol. 1997 Apr;75(2):167-75. Unique Identifier : AIDSLINE MED/97261643; Taylor-Robinson AW; Department of Biology, University of Leeds, United Kingdom.; BGYAWTR@LEEDS.AC.UK; Cloned Th1 cells, but not Th2 cells, specific for malaria antigen, produce nitric oxide (NO) when activated with specific antigen or Con A. Furthermore, NO inhibits proliferation of, and production of IL-2 and IFN-gamma by, Th1 but not Th2 cells. Here, it is demonstrat
A possible role of pre-existing IgM/IgG antibodies in determining immune response type.: Immunol Cell Biol. 1997 Apr;75(2):176-80. Unique Identifier : AIDSLINE MED/97261644; Seledtsov VI; Seledtsova GV; Institute of Clinical Immunology, Novosibirsk, Russia.; On the basis of the data indicating the existence of two types of immuno-protection, namely macrophage-mediated and mast cell-basophil-mediated, it is argued that by reacting with potential pathogens, pre-existing IgM and IgG antibodies (both natural and induced by environmental microflora) might promote involvement o
Plant immunomodulators for termination of unwanted pregnancy and for contraception and reproductive health.: Immunol Cell Biol. 1997 Apr;75(2):190-2. Unique Identifier : AIDSLINE MED/97261647; Talwar GP; Raghuvanshi P; Misra R; Mukherjee S; Shah S; Reproductive Health and Vaccinology Division, International; Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali; Marg, New Delhi, India.; Neem (Azadirachta indica) seed and leaf extracts have spermicidal, anti-microbial, anti-fungal and anti-viral properties. They are also immunomodulators that induce primarily a TH1 type response. These properties are being exploited to develop two different useful methods of fertility control. Neem extracts given oral
SLAM and its role in T cell activation and Th cell responses.: Immunol Cell Biol. 1997 Apr;75(2):202-5. Unique Identifier : AIDSLINE MED/97261650; Aversa G; Carballido J; Punnonen J; Chang CC; Hauser T; Cocks BG; De Vries JE; Department of Human Immunology, DNAX Research Institute of; Molecular and Cellular Biology, Palo Alto, California 94304-1104,; USA.; Following the initial events of T cell activation, triggered by binding of specific peptide-MHC complex to the TCR for antigen and engagement of costimulatory molecules, a number of activation molecules are expressed on the cell surface. Many of these molecules regulate T cell function, T-T cell interactions and the i
Change in CD4+ cell enumeration following aerobic exercise training in HIV-1 disease: possible mechanisms and practical applications.: Int J Sports Med. 1997 Mar;18 Suppl 1:S56-61. Unique Identifier : AIDSLINE MED/97275386; LaPerriere A; Klimas N; Fletcher MA; Perry A; Ironson G; Perna F; Schneiderman N; Department of Psychiatry, University of Miami, Florida, USA.; Growing evidence suggests that routine physical activity, by individuals who are HIV-1 infected, may have significant impact on several important components of good health. Some of the physical benefits noted are: an increase in cardiopulmonary fitness, improved muscle function, and weight gain, while psychological be
Exercise immunology: practical applications.: Int J Sports Med. 1997 Mar;18 Suppl 1:S91-100. Unique Identifier : AIDSLINE MED/97275391; Nieman DC; Department of Health and Exercise Science, Appalachian State; University, USA.; During the last 95 years, 629 papers (60% in the 1990s) dealing specifically with exercise and immunology have been published. Major findings of practical importance in terms of public health and athletic endeavor include: (a) In response to acute exercise (the most frequently studied area of exercise immunology), a r
Immunodepression induced by carbamazepine administration is mediated by CD 8+ spleen T cells.: Int J Tissue React. 1996;18(2-3):81-5. Unique Identifier : AIDSLINE MED/97217809; Andrade-Mena CE; Department of Scientific Investigation, University Centre of; Health Sciences, University of Guadalajara, Mexico.; The values observed in this series of experiments showed that CD 8+ spleen T cells obtained from 15-mg/kg carbamazepine (CBZ)-treated donor mice were capable of diminishing both humoral and cellular immune responses of normal spleen cells when transferred into lethally irradiated recipient animals. Immune responses we
[Sexually transmitted diseases in HIV infection]: Hautarzt. 1997 Mar;48(3):206-13; quiz 213. Unique Identifier : AIDSLINE MED/97268254; Hartmann M; Petzoldt D; Universitats-Hautklinik Heidelberg.
Antiviral resistance: mechanisms, clinical significance, and future implications.: J Antimicrob Chemother. 1996 Mar;37(3):403-21. Unique Identifier : AIDSLINE MED/97012618; Kimberlin DW; Whitley RJ; Department of Pediatrics, The University of Alabama at; Birmingham, 35233, USA.; The increased awareness of antiviral resistance over the past decade has paralleled the development of new antiviral agents. While such resistant viral isolates are of clinical significance primarily in immunocompromised individuals, the development and transmission of such mutants have been reported in immunocompeten
Comparison of the activity of fluoroquinolones against Mycobacterium avium in cell-free systems and a human monocyte in-vitro infection model.: J Antimicrob Chemother. 1996 Mar;37(3):491-500. Unique Identifier : AIDSLINE MED/97012626; Shiratsuchi H; Jacobs MR; Pearson AJ; Venkataprasad N; Klopman G; Ellner JJ; Department of Medicine, Case Western Reserve University,; Cleveland, Ohio 44106, USA.; Mycobacterium avium frequently causes disseminated infection in advanced AIDS. Some quinolones including ciprofloxacin and sparfloxacin have anti-M. avium activity in cell-free systems in vitro. Acidic conditions within macrophages and variable intracellular drug penetration and compartmentalization may, however, alte
Activity of rifabutin, clarithromycin, ethambutol, sparfloxacin and amikacin, alone and in combination, against Mycobacterium avium complex in human macrophages.: J Antimicrob Chemother. 1996 Mar;37(3):501-10. Unique Identifier : AIDSLINE MED/97012627; Pellegrin I; Maugein J; Lapeyre C; Barbeau P; Leng B; Pellegrin JL; Laboratoire de Bacteriologie, Hopital Haut-Leveque (CHR; Bordeaux), Pessac, France.; Disseminated infection with Microbacterium avium complex (MAC) in patients with AIDS is currently treated with a combination of antimycobacterial agents in order to prevent the selection of resistant mutant strains. Although clinical and microbiological responses can generally be achieved within a few weeks, relapses
HIV-induced cytopathology and viral load in a pentamidine-treated lymphocytic cell line.: J Antimicrob Chemother. 1996 Mar;37(3):535-43. Unique Identifier : AIDSLINE MED/97012630; Arnott MA; Hay J; Peutherer JF; Department of Medical Microbiology, The University of Edinburgh; Medical School, UK.; Preincubation of CD4 lymphocytes with pentamidine isethionate at a concentration of 1.5 mg/L then removal from incubation medium prior to addition of HIV-1, or incubation of cells with the drug and virus simultaneously, increased HIV-1 DNA load but reduced p24 antigen release. The number of syncytia generated was not
Phase I dose-escalation pharmacokinetics of AZT-P-ddI (IVX-E-59) in patients with human immunodeficiency virus.: J Clin Pharmacol. 1997 Mar;37(3):201-13. Unique Identifier : AIDSLINE MED/97244646; Zhou XJ; Squires K; Pan-Zhou XR; Bernhard S; Agrofoglio L; Kirk M; Duchin KL; Sommadossi JP; Department of Pharmacology, University of Alabama at Birmingham; (UAB) 35294-0019, USA.; 3 -Azido-3 -deoxythymidilyl-(5 ,5 )-2 ,3 -dideoxy-5 -inosinic acid (AZT-P-ddI, IVX-E-59, Scriptene) is a heterodimer composed of one molecule of 3 -azido-3 -deoxythymidine (zidovudine or AZT) and one molecule of 2 ,3 -dideoxyinosine (didanosine or ddI) linked through their 5 positions by a phosphate bond. AZT-P-ddI e
The potential role of lycopene for human health.: J Am Coll Nutr. 1997 Apr;16(2):109-26. Unique Identifier : AIDSLINE MED/97254801; Gerster H; Vitamin Research Department, F. Hoffmann-La Roche Ltd, Basel,; Switzerland.; Lycopene is one of the major carotenoids in Western diets and is found almost exclusively in tomatoes and tomato products. It accounts for about 50% of carotenoids in human serum. Among the common dietary carotenoids lycopene has the highest singlet oxygen quenching capacity in vitro. Other outstanding features are it
Predominance of type 2 cytokine-producing CD4+ and CD8+ cells in patients with atopic dermatitis.: J Allergy Clin Immunol. 1997 May;99(5):673-82. Unique Identifier : AIDSLINE MED/97300815; Nakazawa M; Sugi N; Kawaguchi H; Ishii N; Nakajima H; Minami M; Department of Immunology and Parasitology, School of Medicine,; Yokohama City University, Japan.; BACKGROUND: Recently, increased IL-4 and decreased interferon-gamma (IFN-gamma) production in peripheral blood mononuclear cells (PBMCs) from patients with atopic dermatitis have been reported by several groups. They measured the total amount of each cytokine in culture supernatants in their studies. These studies sug
Routine preoperative screening for human immunodeficiency virus in a general hospital, Saudi Arabia [letter]: Infect Control Hosp Epidemiol. 1997 Mar;18(3):158-9. Unique Identifier : AIDSLINE MED/97245898; Zawawi TH; Abdelaal MA; Mohamed AY; Rowbottom DJ; Alyafi WA; Marzouki KH; Rashed AA
Triple combination antiretroviral prophylaxis for needlestick exposure to HIV [letter]: Infect Control Hosp Epidemiol. 1997 Mar;18(3):161. Unique Identifier : AIDSLINE MED/97245901; Rich JD; Ramratnam B; Flanigan TP
HIV transmission from surgeon to patient [news]: Infect Control Hosp Epidemiol. 1997 Mar;18(3):216. Unique Identifier : AIDSLINE MED/97245913
National tuberculosis control programme.: J Indian Med Assoc. 1996 Oct;94(10):372-5, 384. Unique Identifier : AIDSLINE MED/97286728; Khatri GR; Ministry of Health and Family Welfare, Government of India, New; Delhi.
Faulty prescription--an avoidable cause of multidrug resistance tuberculosis.: J Indian Med Assoc. 1996 Oct;94(10):385-8. Unique Identifier : AIDSLINE MED/97286732; Jain RF; Government GG Rathi TB Hospital, Amravati.
The problem of compliance to cholesterol altering therapy.: J Intern Med. 1997 Apr;241(4):317-25. Unique Identifier : AIDSLINE MED/97303278; Insull W; Lipid Research Clinic, Baylor College of Medicine, Houston,; Texas, USA.; This review s purpose is to describe for the practicing clinician the current knowledge about patient compliance to cholesterol-altering drugs and about procedures for compliance management applicable to clinical practice in the United States . Compliance is defined for four commonly me
Effectiveness of node-link mapping enhanced counseling for opiate addicts: a 12-month posttreatment follow-up.: J Nerv Ment Dis. 1997 May;185(5):306-13. Unique Identifier : AIDSLINE MED/97315802; Joe GW; Dansereau DF; Pitre U; Simpson DD; Institute of Behavioral Research Texas Christian University, Fort; Worth 76129, USA.; Drug abuse counseling was enhanced by node-link mapping, a visual representation technique, and evaluated in a posttreatment follow-up study. Clients randomly assigned to receive mapping counseling reported less criminal activity 12 months after treatment than did clients in the standard counseling condition. It was a
Spinonin, a novel glycoside from Ononis spinosa subsp. leiosperma.: J Nat Prod. 1997 Apr;60(4):378-81. Unique Identifier : AIDSLINE MED/97323893; Kirmizigul S; Goren N; Yang SW; Cordell GA; Bozok-Johansson C; Department of Organic Chemistry, Faculty of Science, Ege; University, Izmir, Turkey.; The roots of Ononis spinosa subsp. leiosperma (Leguminosae) afforded a new glycoside, spinonin (1), possessing a novel skeleton, in addition to the known isoflavonoid glycoside, ononin [7beta-(glucosyloxy)formononetin] (2) and the known pterocarpan, 7-demethoxy-7-D-(glucosyloxy)homopterocarpin (3). The structure of th
A case of Machado-Joseph disease presenting with spastic paraparesis [letter]: J Neurol Neurosurg Psychiatry. 1997 May;62(5):542-3. Unique Identifier : AIDSLINE MED/97297991; Kaneko A; Narabayashi Y; Itokawa K; Nakazato Y; Hosokawa T; Iwasaki S; Ohno R; Hamaguchi K; Ikeda M; Nomura M
Granulomatous myositis: pathologic re-evaluation by immunohistochemical analysis of infiltrating mononuclear cells.: J Neurol Sci. 1997 Jan;145(1):41-7. Unique Identifier : AIDSLINE MED/97225757; Takanashi T; Suzuki Y; Yoshino Y; Nonaka I; Department of Ultrastructural Research, National Center of; Neurology and Psychiatry (NCNP), Kodaira, Tokyo, Japan.; To characterize the non-caseating granuloma formation in granulomatous myositis, we analyzed infiltrating mononuclear cells in 7 patients including 2 sarcoid patients, using monoclonal antibodies with a modified immunoperoxidase method. All granulomas consisting of epithelioid, infiltrating mononuclear cells and multi
Raised serum nitrate and nitrite levels in patients with multiple sclerosis.: J Neurol Sci. 1997 Jan;145(1):77-81. Unique Identifier : AIDSLINE MED/97225762; Giovannoni G; Heales SJ; Silver NC; O'Riordan J; Miller RF; Land JM; Clark JB; Thompson EJ; Department of Neuroimmunology, The National Hospital for; Neurology and Neurosurgery, London, UK.; Nitric oxide and its highly reactive derivative peroxynitrite have been implicated as non-specific inflammatory mediators of neuronal and oligodendrocyte damage and death in multiple sclerosis. In a cross-sectional study we found levels of the nitric oxide metabolites nitrate and nitrite to be raised in the serum of p
Diagnostic criteria and clinical procedures in HIV-1 associated progressive multifocal leukoencephalopathy.: J Neurol Sci. 1997 Mar 20;147(1):63-72. Unique Identifier : AIDSLINE MED/97247939; von Giesen HJ; Neuen-Jacob E; Dorries K; Jablonowski H; Roick H; Arendt G; Department of Neurology, Heinrich-Heine-Universitat, Federal; Republic of Germany. arendt@neurologie.uni-duesseldorf.de; The diagnosis of definite progressive multifocal leukoencephalopathy (PML) has been a neuropathological domain. We reviewed all Human Immunodeficiency Virus Type 1 (HIV-1) seropositive patients in our institution between 01.01.1989 and 31.12.1994 and identified 20/823 cases with PML by clinical and imaging criteria. D
Clinic services for persons with AIDS. Experience in a high-prevalence state [see comments]: J Gen Intern Med. 1997 Mar;12(3):141-9. Unique Identifier : AIDSLINE MED/97254728; Markson LE; Turner BJ; Cocroft J; Houchens R; Fanning TR; Center for Research in Medical Education and Health Care,; Jefferson Medical College, Philadelphia, PA, USA.; OBJECTIVE: To profile characteristics of clinics caring for persons with advanced HIV infection. DESIGN AND SETTING: Survey of clinic directors in New York State. PARTICIPANTS: Newly diagnosed Medicaid-enrolled AIDS patients in New York state in federal fiscal years 1987-1992 (n = 6,184) managed by 62 HIV specialty, 5
Race, gender, drug use, and participation in AIDS clinical trials. Lessons from a municipal hospital cohort [see comments]: J Gen Intern Med. 1997 Mar;12(3):150-7. Unique Identifier : AIDSLINE MED/97254729; Stone VE; Mauch MY; Steger K; Janas SF; Craven DE; Section of General Internal Medicine, University School of; Medicine, Boston, MA, USA.; OBJECTIVES: To determine whether participation rates of women, persons of color, and injection drug users in AIDS clinical trials are similar to those of other HIV/AIDS patients, and to examine whether differences in patients knowledge of clinical trails or reasons for not participating explain differences in partici
Quality in HIV/AIDS care. Specialty-related or experience-related? [editorial; comment]: J Gen Intern Med. 1997 Mar;12(3):195-7. Unique Identifier : AIDSLINE MED/97254737; Holmes WC
AIDS clinical trials. Is there access for all? [editorial; comment]: J Gen Intern Med. 1997 Mar;12(3):198-9. Unique Identifier : AIDSLINE MED/97254738; Lynn LA
The hospital cost of congenital syphilis.: J Pediatr. 1997 May;130(5):752-8. Unique Identifier : AIDSLINE MED/97296816; Bateman DA; Phibbs CS; Joyce T; Heagarty MC; Department of Pediatrics, Harlem Hospital, New York, New York,; USA.; OBJECTIVE: To determine the hospital cost of caring for newborn infants with congenital syphilis. STUDY POPULATION: All live-born singleton neonates with birth weight greater than 500 gm at an inner-city municipal hospital in New York City in 1989. METHODS: We compared the characteristics of 114 infants with case-comp
Endoscopy of the upper gastrointestinal tract as a diagnostic tool for children with human immunodeficiency virus infection.: J Pediatr. 1997 May;130(5):766-73. Unique Identifier : AIDSLINE MED/97296818; Miller TL; McQuinn LB; Orav EJ; Combined Program in Pediatric Gastroenterology and Nutrition,; Children's Hospital, Boston, Massachusetts, USA.; OBJECTIVE: The purpose of this study was to determine the prevalence of upper gastrointestinal tract lesions in children with human immunodeficiency virus (HIV) infection who undergo endoscopy of the upper gastrointestinal tract and to identify important clinical predictors of abnormal endoscopic results. METHODS: All
Inhibition and interaction of cytochrome P450 of Candida krusei with azole antifungal drugs.: J Med Vet Mycol. 1997 Jan-Feb;35(1):19-25. Unique Identifier : AIDSLINE MED/97215216; Venkateswarlu K; Denning DW; Kelly SL; Krebs's Institute for Biomolecular Research, Department of; Molecular Biology and Biotechnology, University of Sheffield, UK.; Candida krusei has become an increasingly important invasive pathogen, particularly in AIDS patients and is highly resistant to fluconazole. In vitro growth inhibition studies revealed that fluconazole and ketoconazole were approximately 800- and 19-fold less inhibitory than itraconazole. The inhibition and interactio
Crytococcus neoformans var. gattii in an AIDS patient: first observation in Mexico.: J Med Vet Mycol. 1997 Jan-Feb;35(1):57-9. Unique Identifier : AIDSLINE MED/97215222; Castanon-Olivares LR; Lopez-Martinez R; Barriga-Angulo G; Rios-Rosas C; Departamento de Microbiologia y Parasitologia, Facultad de; Medicina, Universidad Nacional Autonoma de Mexico, Mexico, DF.; We report the first, as far as we know, Mexican case of meningitis caused by Cryptococcus neoformans var. gattii serotype B associated with AIDS in a female patient. The HIV was transmitted to the patient through a blood transfusion. This patient represents, worldwide, the ninth case of C. neoformans var. gattii in pa
Cell-mediated immunity in HIV seronegative patients recovered from Cryptococcus neoformans var. gattii meningitis.: J Med Vet Mycol. 1997 Jan-Feb;35(1):7-11. Unique Identifier : AIDSLINE MED/97215214; Seaton RA; Naraqi S; Wembri JP; Warrell DA; Department of Clinical Sciences, Medical Faculty, University of; Papua New Guinea, PNG.; Cell-mediated immunity was assessed in 37 HIV seronegative healthy patients cured of Cryptococcus neoformans var. gattii meningitis and compared with matched controls using a multitest device which simultaneously injects seven standardized common antigens intradermally. Responses in patients and controls were similar:
Inflammatory and immune mediators in crevicular fluid from HIV-infected injecting drug users.: J Periodontol. 1997 Mar;68(3):249-55. Unique Identifier : AIDSLINE MED/97254790; Grbic JT; Lamster IB; Mitchell-Lewis D; Division of Periodontics, School of Dental and Oral Surgery,; Columbia University, New York, NY, USA.; Gingival crevicular fluid (GCF) levels of the polymorphonuclear leukocyte (PMN) lysosomal enzyme beta-glucuronidase (beta G), the pro-inflammatory cytokine interleukin 1 beta (IL-1 beta), and immunoglobulins (IgA, IgG, and IgM) were examined in 16 HIV seropositive (HIV+) and 10 HIV seronegative (HIV-) injecting drug u
Dihydro(alkylthio)(naphthylmethyl)oxopyrimidines: novel non-nucleoside reverse transcriptase inhibitors of the S-DABO series.: J Med Chem. 1997 May 9;40(10):1447-54. Unique Identifier : AIDSLINE MED/97299818; Mai A; Artico M; Sbardella G; Quartarone S; Massa S; Loi AG; De Montis A; Scintu F; Putzolu M; La Colla P; Dipartimento di Studi Farmaceutici, Universita di Roma La; Sapienza, Rome, Italy.; Novel compounds related to 2-(cyclohexylthio)-3,4-dihydro-5-methyl-6-(3-methylbenzyl)-4-ox opyrimidine (3c, MC 639) have been synthesized and tested as inhibitors of human immunodeficiency virus type-1 (HIV-1). Reaction of thiourea with ethyl arylmethylacetoacetates furnished 5-alkyl-6-(arylmethyl)-3,4-dihydro-2-merca
Improved P1/P1' substituents for cyclic urea based HIV-1 protease inhibitors: synthesis, structure-activity relationship, and X-ray crystal structure analysis.: J Med Chem. 1997 May 9;40(10):1465-74. Unique Identifier : AIDSLINE MED/97299820; Nugiel DA; Jacobs K; Cornelius L; Chang CH; Jadhav PK; Holler ER; Klabe RM; Bacheler LT; Cordova B; Garber S; Reid C; Logue KA; Gorey-Feret LJ; Lam GN; Erickson-Viitanen S; Seitz SP; The DuPont Merck Pharmaceutical Company, Wilmington, Delaware; 19880-0500, USA.; We present several novel P1/P1 substituents that can replace the characteristic benzyl P1/P1 moiety of the cyclic urea based HIV protease inhibitor series. These substituents typically provide 5-10-fold improvements in binding affinity compared to the unsubstituted benzyl analogs. The best substituent was the 3,4-(e
Preparation and anti-HIV activity of N-3-substituted thymidine nucleoside analogs.: J Med Chem. 1997 May 9;40(10):1550-8. Unique Identifier : AIDSLINE MED/97299827; Adams DR; Perez C; Maillard M; Florent JC; Evers M; Henin Y; Litvak S; Litvak L; Monneret C; Grierson DS; Institut de Chimie des Substances Naturelles CNRS,; Gif-sur-Yvette, France.; A series of 22 derivatives of AZT substituted at the N-3 position of the thymine base were prepared and evaluated for anti-HIV activity in cell culture (Lai strain of HIV-1 in CEM-c113 cells). The AZT analogs bearing a N-3 amino group (7), a hydroxyal
Cell-homologous genes in the Kaposi's sarcoma-associated rhadinovirus human herpesvirus 8: determinants of its pathogenicity?: J Virol. 1997 Jun;71(6):4187-92. Unique Identifier : AIDSLINE GENBANK/U93872; Neipel F; Albrecht JC; Fleckenstein B; Institut fur Klinische und Molekulare Virologie, Universitat; Erlangen-Nurnberg, Erlangen, Germany.
The cyclin encoded by Kaposi's sarcoma-associated herpesvirus stimulates cdk6 to phosphorylate the retinoblastoma protein and histone H1.: J Virol. 1997 Jun;71(6):4193-8. Unique Identifier : AIDSLINE MED/97296221; Godden-Kent D; Talbot SJ; Boshoff C; Chang Y; Moore P; Weiss RA; Mittnacht S; Centre for Molecular and Cell Biology, The Institute of Cancer; Research, Chester Beatty Laboratories, London, United Kingdom.; Kaposi s sarcoma-associated herpesvirus (KSHV or human herpesvirus 8) is a novel gammaherpesvirus implicated in the cause of Kaposi s sarcoma and certain malignancies of lymphatic origin. One of the candidate genes possibly involved in promoting tumor development is an open reading frame (ORF) with sequence similarity
Characterization of molecularly cloned simian-human immunodeficiency viruses causing rapid CD4+ lymphocyte depletion in rhesus monkeys.: J Virol. 1997 Jun;71(6):4218-25. Unique Identifier : AIDSLINE GENBANK/U89134; Karlsson GB; Halloran M; Li J; Park IW; Gomila R; Reimann KA; Axthelm MK; Iliff SA; Letvin NL; Sodroski J; Division of Human Retrovirology, Dana-Farber Cancer Institute,; Boston, Massachusetts 02115, USA.; In vivo passage of a chimeric simian-human immunodeficiency virus (SHIV-89.6) expressing the human immunodeficiency virus type 1 (HIV-1) tat, rev, vpu, and env genes generated pathogenic viruses (SHIV-89.6P) inducing rapid CD4+ lymphocyte depletion and AIDS-like illness in rhesus monkeys (K. Reimann, J. T. Li, R. Veaz
Genetic drift can dominate short-term human immunodeficiency virus type 1 nef quasispecies evolution in vivo.: J Virol. 1997 Jun;71(6):4233-40. Unique Identifier : AIDSLINE +; Plikat U; Nieselt-Struwe K; Meyerhans A; Abteilung Virologie, Institut fur Medizinische Mikrobiologie und; Hygiene, Universitat Freiburg, Germany.; The evolution of human immunodeficiency virus (HIV) type 1 nef quasispecies in a patient clonally infected with a contaminated batch of blood clotting factor IX was monitored. nef sequences were derived at 11, 25, and 41 months postinfection from infected peripheral blood mononuclear cells after molecular cloning of P
Genetic diversity of feline immunodeficiency virus: dual infection, recombination, and distinct evolutionary rates among envelope sequence clades.: J Virol. 1997 Jun;71(6):4241-53. Unique Identifier : AIDSLINE GENBANK/U57023; Bachmann MH; Mathiason-Dubard C; Learn GH; Rodrigo AG; Sodora DL; Mazzetti P; Hoover EA; Mullins JI; Department of Cancer Biology, Harvard School of Public Health,; Boston, Massachusetts, USA.; For the rapid genetic analysis of feline immunodeficiency virus (FIV), we developed a heteroduplex mobility assay (HMA) that utilizes a PCR-amplified fragment of the FIV envelope gene spanning the third and fourth variable regions of the envelope surface protein coding sequence. Viral sequences were successfully ampli
The antiretrovirus drug 3'-azido-3'-deoxythymidine increases the retrovirus mutation rate.: J Virol. 1997 Jun;71(6):4254-63. Unique Identifier : AIDSLINE MED/97296228; Julias JG; Kim T; Arnold G; Pathak VK; Department of Biochemistry, Mary Babb Randolph Cancer Center,; West Virginia University, Morgantown 26506, USA.; It was previously observed that the nucleoside analog 5-azacytidine increased the spleen necrosis virus (SNV) mutation rate 13-fold in one cycle of retrovirus replication (V. K. Pathak and H. M. Temin, J. Virol. 66:3093-3100, 1992). Based on this observation, we hypothesized that nucleoside analogs used as antiviral d
Pathological changes in the spleens of gamma interferon receptor-deficient mice infected with murine gammaherpesvirus: a role for CD8 T cells.: J Virol. 1997 Jun;71(6):4278-83. Unique Identifier : AIDSLINE MED/97296231; Dutia BM; Clarke CJ; Allen DJ; Nash AA; Department of Veterinary Pathology, University of Edinburgh,; Summerhall, United Kingdom. B.M.Dutia@ed.ac.uk; Murine gammaherpesvirus is a natural rodent pathogen which causes a primary infection in the lungs and establishes a persistent infection in B lymphocytes. During the primary infection, large amounts of gamma interferon (IFN-gamma) are produced by spleen, mediastinal, and cervical lymph node cells. To investigate the
Divergent patterns of progression to AIDS after infection from the same source: human immunodeficiency virus type 1 evolution and antiviral responses.: J Virol. 1997 Jun;71(6):4284-95. Unique Identifier : AIDSLINE +; Liu SL; Schacker T; Musey L; Shriner D; McElrath MJ; Corey L; Mullins JI; Department of Microbiology, University of Washington, Seattle; 98105-7740, USA.; The rate of progression to AIDS in human immunodeficiency virus type 1 (HIV-1)-infected individuals is determined by a complex series of interactions between the host and virus. Here we evaluate virologic properties and host responses in two men near-simultaneously infected with HIV-1 from the same sexual partner--one
Antibodies with specificity to native gp120 and neutralization activity against primary human immunodeficiency virus type 1 isolates elicited by immunization with oligomeric gp160.: J Virol. 1997 Jun;71(6):4319-30. Unique Identifier : AIDSLINE MED/97296236; VanCott TC; Mascola JR; Kaminski RW; Kalyanaraman V; Hallberg PL; Burnett PR; Ulrich JT; Rechtman DJ; Birx DL; Henry M. Jackson Foundation, Rockville, Maryland 20850, USA.; tvancott@hiv.hjf.org; Current human immunodeficiency virus type 1 (HIV-1) envelope vaccine candidates elicit high antibody binding titers with neutralizing activity against T-cell line-adapted but not primary HIV-1 isolates. Serum antibodies from these human vaccine recipients were also found to be preferentially directed to linear epitope
Conservation and host specificity of Vpr-mediated cell cycle arrest suggest a fundamental role in primate lentivirus evolution and biology.: J Virol. 1997 Jun;71(6):4331-8. Unique Identifier : AIDSLINE GENBANK/U78792; Stivahtis GL; Soares MA; Vodicka MA; Hahn BH; Emerman M; Program in Molecular and Cellular Biology, University of; Washington, Seattle 98195, USA.; The human immunodeficiency virus type 1 (HIV-1) Vpr protein prevents infected cells from passing through mitosis by arresting them in the G2 phase of the cell cycle. Vpr is conserved among all primate lentiviruses, suggesting an important role in the virus life cycle. Moreover, in this study we show that the ability t
Retention of viral infectivity after extensive mutation of the highly conserved immunodominant domain of the feline immunodeficiency virus envelope.: J Virol. 1997 Jun;71(6):4339-46. Unique Identifier : AIDSLINE MED/97296238; Pancino G; Sonigo P; Genetique des Virus et Immunopharmacologie Moleculaire; (ICGM-CNRS UPR0415), Institut Cochin de Genetique Moleculaire,; Paris, France. pancino@cochin.inserm.fr; In lentiviruses, including human immunodeficiency virus and feline immunodeficiency virus (FIV), the principal immunodominant domain (PID) of the transmembrane glycoprotein elicits a strong humoral response in infected hosts. The PID is marked by the presence of two cysteines that delimit a sequence, composed of five
The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix.: J Virol. 1997 Jun;71(6):4372-7. Unique Identifier : AIDSLINE MED/97296242; Swingler S; Gallay P; Camaur D; Song J; Abo A; Trono D; Infectious Disease Laboratory, The Salk Institute for Biological; Studies, La Jolla, California 92037, USA.; The human immunodeficiency virus type 1 matrix (MA) protein is phosphorylated during virion maturation on its C-terminal tyrosine and on several serine residues. Whereas MA tyrosine phosphorylation facilitates viral nuclear import, the significance of MA serine phosphorylation remains unclear. Here, we report that MA
Effect of mutations in the nucleocapsid protein (NCp7) upon Pr160(gag-pol) and tRNA(Lys) incorporation into human immunodeficiency virus type 1.: J Virol. 1997 Jun;71(6):4378-84. Unique Identifier : AIDSLINE MED/97296243; Huang Y; Khorchid A; Wang J; Parniak MA; Darlix JL; Wainberg MA; Kleiman L; Jewish General Hospital, and Department of Microbiology and; Immunology, McGill University, Montreal, Quebec, Canada.; COS-7 cells were transfected with DNAs containing mutations in the NCp7 sequences of human immunodeficiency virus. Selective incorporation into the virus of tRNA(Lys) was measured by two-dimensional polyacrylamide gel electrophoresis, and Pr160(gag-pol) incorporation into the virus was detected in Western blots of vir
Characterization of human immunodeficiency virus type 1 matrix revertants: effects on virus assembly, Gag processing, and Env incorporation into virions.: J Virol. 1997 Jun;71(6):4409-18. Unique Identifier : AIDSLINE MED/97296247; Ono A; Huang M; Freed EO; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, Maryland 20892-0460, USA.; The matrix protein of human immunodeficiency virus type 1 (HIV-1) has been postulated to serve a variety of functions in the virus life cycle. Previously, we introduced a large number of mutations into the HIV-1 matrix and determined the effects on virus replication. These studies identified domains involved in virus
CD4-independent infection by human immunodeficiency virus type 2 strain ROD/B: the role of the N-terminal domain of CXCR-4 in fusion and entry.: J Virol. 1997 Jun;71(6):4419-24. Unique Identifier : AIDSLINE MED/97296248; Potempa S; Picard L; Reeves JD; Wilkinson D; Weiss RA; Talbot SJ; Chester Beatty Laboratories, Institute of Cancer Research,; London, United Kingdom.; The human immunodeficiency virus type 2 (HIV-2) strain ROD/B can efficiently use the 7tm chemokine receptor CXCR-4 as a primary receptor to enter CD4-negative cells. We have stably expressed CXCR-4 on mink lung Mv-1-lu and feline kidney CCC cells (normally restrictive to HIV entry) and have shown efficient fusion, ent
In vitro assembly of virus-like particles with Rous sarcoma virus Gag deletion mutants: identification of the p10 domain as a morphological determinant in the formation of spherical particles.: J Virol. 1997 Jun;71(6):4425-35. Unique Identifier : AIDSLINE MED/97296249; Campbell S; Vogt VM; Section of Biochemistry, Molecular and Cell Biology, Cornell; University, Ithaca, New York 14853, USA.; Retroviruses are unusual in that expression of a single protein, Gag, leads to budding of virus-like particles into the extracellular space. We have developed conditions under which virus-like particles are formed spontaneously in vitro from fragments of Rous sarcoma virus (RSV) Gag protein purified after expression i
Differential susceptibility of naive and memory CD4+ T cells to the cytopathic effects of infection with human immunodeficiency virus type 1 strain LAI.: J Virol. 1997 Jun;71(6):4436-44. Unique Identifier : AIDSLINE MED/97296250; Chun TW; Chadwick K; Margolick J; Siliciano RF; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, Maryland 21205, USA.; CD4+ T lymphocytes of individuals infected with human immunodeficiency virus type 1 (HIV-1) exhibit a qualitative defect in their ability to mount memory responses to previously encountered antigens although their responses to mitogens remain normal. T cells responsible for memory responses can be distinguished from n
Human T-cell leukemia virus type 1 Tax protein transforms rat fibroblasts via two distinct pathways.: J Virol. 1997 Jun;71(6):4445-51. Unique Identifier : AIDSLINE MED/97296251; Matsumoto K; Shibata H; Fujisawa JI; Inoue H; Hakura A; Tsukahara T; Fujii M; Osaka Red Cross Blood Center, Johtoh-ku, Japan.; The human T-cell leukemia virus type 1 (HTLV-1) Tax protein activates the transcription of several cellular genes. This function is thought to play a critical role in the Tax-dependent transformation step in HTLV-1 leukemogenesis. Tax activates transcription via three enhancers: the cyclic AMP response element (CRE)-l
Putative alpha-helical structures in the human immunodeficiency virus type 1 Vpu protein and CD4 are involved in binding and degradation of the CD4 molecule.: J Virol. 1997 Jun;71(6):4452-60. Unique Identifier : AIDSLINE MED/97296252; Tiganos E; Yao XJ; Friborg J; Daniel N; Cohen EA; Departement de Microbiologie et Immunologie, Faculte de; Medecine, Universite de Montreal, Quebec, Canada.; The human immunodeficiency virus type 1 (HIV-1) vpu gene encodes a 16-kDa class I integral membrane phosphoprotein with an N-terminal membrane-spanning region and a C-terminal cytoplasmic domain. In the cytoplasmic domain, two amphipathic alpha-helices joined by a flexible turn containing two phosphoacceptor sites hav
Incorporation of Pr160(gag-pol) into virus particles requires the presence of both the major homology region and adjacent C-terminal capsid sequences within the Gag-Pol polyprotein.: J Virol. 1997 Jun;71(6):4472-8. Unique Identifier : AIDSLINE MED/97296254; Huang M; Martin MA; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, Maryland 20892, USA.; The determinants critical for the incorporation of Pr160(gag-pol) into human immunodeficiency virus type 1 (HIV-1) particles were examined by cotransfecting cells with (i) a plasmid expressing wild-type Gag protein and (ii) a series of chimeric Gag-Pol expression plasmids in which individual murine leukemia virus (MLV
Broad spectrum of in vivo fitness of human immunodeficiency virus type 1 subpopulations differing at reverse transcriptase codons 41 and 215.: J Virol. 1997 Jun;71(6):4479-84. Unique Identifier : AIDSLINE GENBANK/K03455; Goudsmit J; de Ronde A; de Rooij E; de Boer R; Department of Human Retrovirology, Academic Medical Center,; University of Amsterdam, The Netherlands.; Viral populations in a human immunodeficiency virus type 1 (HIV-1)-infected individual behave as a quasispecies with a rated distribution of fitness variants. Fitness distributions in naturally occurring viral populations have been difficult to study due to the lack of markers for individual virus clones and complicat
cis-Acting inhibitory elements within the pol-env region of human T-cell leukemia virus type 1 possibly involved in viral persistence.: J Virol. 1997 Jun;71(6):4485-94. Unique Identifier : AIDSLINE MED/97296256; Saiga A; Orita S; Minoura-Tada N; Maeda M; Aono Y; Asakawa M; Nakahara K; Kubota R; Osame M; Igarashi H; Shionogi Institute for Medical Science, Settsu, Osaka, Japan.; Human T-cell leukemia virus type 1 (HTLV-1) remains latent throughout the life of the carrier, with cells containing the provirus and viral gene expression efficiently down-regulated. On a molecular level, exactly how viruses are down-regulated in vivo remains unresolved. We described here the possibility that down-re
Human T cells recovered from human/Balb radiation chimeras are hypersensitive to human immunodeficiency virus type 1 infection.: J Virol. 1997 Jun;71(6):4495-501. Unique Identifier : AIDSLINE MED/97296257; Shapira-Nahor O; Marcus H; Segall H; Lubin I; Slavin S; Panet A; Reisner Y; Department of Virology, The Hebrew University Hadassah Medical; School, Jerusalem, Israel.; Replication of human immunodeficiency virus type 1 (HIV-1) is regulated by virus-encoded regulatory proteins, as well as by a variety of cellular factors. Productive infection of human T lymphocytes by HIV-1 is dependent upon the activation status of the target cells. In general, short-term mitogenic stimulation of CD
Efficient encapsidation of human immunodeficiency virus type 1 vectors and further characterization of cis elements required for encapsidation.: J Virol. 1997 Jun;71(6):4544-54. Unique Identifier : AIDSLINE MED/97296264; McBride MS; Schwartz MD; Panganiban AT; McArdle Laboratory for Cancer Research, University of Wisconsin; Medical School, Madison 53706, USA.; To determine whether there is a cis-acting effect of translational expression of gag on RNA encapsidation, we compared the encapsidation of wild-type RNA with that of a mutant in which the translation of gag was ablated. This comparison indicated that there is not such a cis effect. To determine what is necessary and
Characterization of the antibody response specific for the human endogenous retrovirus HTDV/HERV-K.: J Virol. 1997 Jun;71(6):4581-8. Unique Identifier : AIDSLINE MED/97296268; Boller K; Janssen O; Schuldes H; Tonjes RR; Kurth R; Paul-Ehrlich-Institut, Langen, Germany.; Boller@em.uni-frankfurt.de; Differentiated human teratocarcinoma cell lines produce the human teratocarcinoma-derived virus (HTDV) particles encoded by the human endogenous retrovirus sequence HERV-K. We screened almost 2,000 human sera for antibodies against this endogenous human retrovirus, HTDV/HERV-K. Specificity of the immunofluorescence re
Evolution of human immunodeficiency virus type 1 in perinatally infected infants with rapid and slow progression to disease.: J Virol. 1997 Jun;71(6):4694-706. Unique Identifier : AIDSLINE +; Salvatori F; Masiero S; Giaquinto C; Wade CM; Brown AJ; Chieco-Bianchi L; De Rossi A; Department of Oncology and Surgical Sciences, AIDS Reference; Center, University of Padova, Italy.; We addressed the relationship between the origin and evolution of human immunodeficiency virus type 1 (HIV-1) variants and disease outcome in perinatally infected infants by studying the V3 regions of viral variants in samples obtained from five transmitting mothers at delivery and obtained sequentially over the first
RevM10-expressing T cells derived in vivo from transduced human hematopoietic stem-progenitor cells inhibit human immunodeficiency virus replication.: J Virol. 1997 Jun;71(6):4707-16. Unique Identifier : AIDSLINE MED/97296280; Bonyhadi ML; Moss K; Voytovich A; Auten J; Kalfoglou C; Plavec I; Forestell S; Su L; Bohnlein E; Kaneshima H; Progenesys Program, SyStemix, Inc., Palo Alto, California 94304,; USA. mbonyhad@stem.com; A key feature of the pathogenesis of human immunodeficiency virus type 1 (HIV-1) infection is the gradual loss of CD4-positive T cells. A number of gene therapy strategies have been designed with the intent of inhibiting HIV replication in mature T cells. As T cells are products of hematolymphoid differentiation, inse
Role of the first and third extracellular domains of CXCR-4 in human immunodeficiency virus coreceptor activity.: J Virol. 1997 Jun;71(6):4744-51. Unique Identifier : AIDSLINE MED/97296284; Brelot A; Heveker N; Pleskoff O; Sol N; Alizon M; INSERM U.332, Institute Cochin de Genetique Moleculaire,; Paris, France.; The CXCR-4 chemokine receptor and CD4 behave as coreceptors for cell line-adapted human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) and for dual-tropic HIV strains, which also use the CCR-5 coreceptor. The cell line-adapted HIV-1 strains LAI and NDK and the dual-tropic HIV-2 strain ROD were able to infect C
Tempo and mode of nucleotide substitutions in gag and env gene fragments in human immunodeficiency virus type 1 populations with a known transmission history.: J Virol. 1997 Jun;71(6):4761-70. Unique Identifier : AIDSLINE MED/97296286; Leitner T; Kumar S; Albert J; Theoretical Biology and Biophysics, Group T-10, Los Alamos; National Laboratory, New Mexico 87545, USA. tkl@t10.lanl.gov; The complex evolutionary process of human immunodeficiency virus type 1 (HIV-1) is marked by a high level of genetic variation. It has been shown that the HIV-1 genome is characterized by variable and more constant regions, unequal nucleotide frequencies, and preference for G-to-A substitutions. However, this knowledg
Open reading frame 26 of human herpesvirus 8 encodes a tetradecanoyl phorbol acetate- and butyrate-inducible 32-kilodalton protein expressed in a body cavity-based lymphoma cell line.: J Virol. 1997 Jun;71(6):4791-7. Unique Identifier : AIDSLINE MED/97296289; O'Neill E; Douglas JL; Chien ML; Garcia JV; Department of Virology and Molecular Biology, St. Jude Children's; Research Hospital, Memphis, Tennessee 38105, USA.; DNA sequences corresponding to a novel herpesvirus (human herpesvirus 8 [HHV8]) are associated with Kaposi s sarcoma (KS), Castleman s disease, and body cavity-based lymphomas (BCBL). Studies of a BCBL-derived cell line suggest a direct correlation between seropositivity against antigens specifically present in such l
Human immunodeficiency virus-associated vasculopathy in transgenic mice.: J Virol. 1997 Jun;71(6):4809-14. Unique Identifier : AIDSLINE MED/97296292; Tinkle BT; Ngo L; Luciw PA; Maciag T; Jay G; Department of Virology, Jerome H. Holland Laboratory, Rockville,; Maryland 20855, USA.; There is substantial clinical evidence for the development of vascular disorders in human immunodeficiency virus (HIV)-infected individuals, particularly in the form of vasculitis. Transgenic mice carrying a replication-defective HIV-1 provirus with selective deletion of the gag, pol, and env genes developed extensive
Efficient pseudotyping of murine leukemia virus particles with chimeric human foamy virus envelope proteins.: J Virol. 1997 Jun;71(6):4815-20. Unique Identifier : AIDSLINE MED/97296293; Lindemann D; Bock M; Schweizer M; Rethwilm A; Institut fur Virologie und Immunobiologie, Wurzburg, Germany.; viro066@rzbox.uni-wuerzburg.de; Incorporation of human foamy virus (HFV) envelope proteins into murine leukemia virus (MuLV) particles was studied in a transient transfection packaging cell system. We report here that wild-type HFV envelope protein can pseudotype MuLV particles, albeit at low efficiency. Complete or partial removal of the HFV cytopl
Association of ERK2 mitogen-activated protein kinase with human immunodeficiency virus particles.: J Virol. 1997 Jun;71(6):4832-7. Unique Identifier : AIDSLINE MED/97296297; Cartier C; Deckert M; Grangeasse C; Trauger R; Jensen F; Bernard A; Cozzone A; Desgranges C; Boyer V; INSERM U271, Lyon, France.; Here we report the presence of a protein kinase activity associated with human immunodeficiency virus type 1 (HIV-1) particles. We observed phosphorylation of five major proteins by the endogenous protein kinase activity. Phosphoamino acid analysis revealed phosphorylated serine and threonine residues. In addition, we
Uracil DNA glycosylase specifically interacts with Vpr of both human immunodeficiency virus type 1 and simian immunodeficiency virus of sooty mangabeys, but binding does not correlate with cell cycle arrest.: J Virol. 1997 Jun;71(6):4842-6. Unique Identifier : AIDSLINE MED/97296299; Selig L; Benichou S; Rogel ME; Wu LI; Vodicka MA; Sire J; Benarous R; Emerman M; Laboratoire de Genetique Moleculaire des Interactions; Proteiques, INSERM U332, ICGM, Universite Paris V, France.; The Vpr protein encoded by human immunodeficiency virus type 1 (HIV-1) is important for growth of virus in macrophages and prevents infected cells from passing into mitosis (G2 arrest). The cellular target for these functions is not known, but Vpr of HIV-1 and the related Vpr from simian immunodeficiency virus of soot
Contribution of virion ICAM-1 to human immunodeficiency virus infectivity and sensitivity to neutralization.: J Virol. 1997 Jun;71(6):4847-51. Unique Identifier : AIDSLINE MED/97296300; Rizzuto CD; Sodroski JG; Division of Human Retrovirology, Dana-Farber Cancer Institute,; Boston, Massachusetts 01225, USA.; Incorporation of the intercellular adhesion molecule ICAM-1 into human immunodeficiency virus type 1 (HIV-1) particles increased virus infectivity on peripheral blood mononuclear cells (PBMCs) by two- to sevenfold. The degree of ICAM-1-mediated enhancement was greater for viruses bearing envelope glycoproteins derived
From the Centers for Disease Control and Prevention. Surveillance for penicillin-nonsusceptible Streptococcus pneumoniae--New York City, 1995.: JAMA. 1997 May 28;277(20):1585-6. Unique Identifier : AIDSLINE MED/97311558
Usefulness of oral mucosal transudate for HIV antibody testing [letter]: JAMA. 1997 May 28;277(20):1591; discussion 1592-3. Unique Identifier : AIDSLINE MED/97311562; Ryder K
Usefulness of oral mucosal transudate for HIV antibody testing [letter]: JAMA. 1997 May 28;277(20):1591; discussion 1592-3. Unique Identifier : AIDSLINE MED/97311563; Tessler LF; Walsh JM
Usefulness of oral mucosal transudate for HIV antibody testing [letter]: JAMA. 1997 May 28;277(20):1591-2; discussion 1592-3. Unique Identifier : AIDSLINE MED/97311564; Frank AP
Usefulness of oral mucosal transudate for HIV antibody testing [letter]: JAMA. 1997 May 28;277(20):1592. Unique Identifier : AIDSLINE MED/97311565; Martinez P; Ortiz de Lejarazu R; Eiros JM; Rodriguez-Torres A
Adult T cell leukemia presenting as multiple submucosal tumors of the intestine: detection of HTLV-I DNA by polymerase chain reaction.: Kobe J Med Sci. 1996 Oct;42(5):325-32. Unique Identifier : AIDSLINE MED/97298522; Kuwabara H; Uda H; Department of Pathology, Kagawa Medical University, Japan.; We discuss a 45-year-old man who presented with ileus due to multiple submucosal tumors of the small and large intestines. Emergency operation was performed and histological examination of the tumors revealed pleomorphic cells with helper/inducer T-cell phenotype. Polymerase chain reaction (PCR) analysis using DNA ext
Regulation of cytokine production in aging: use of recombinant cytokines to upregulate mitogen-stimulated spleen cells.: Mech Ageing Dev. 1997 Feb;93(1-3):157-69. Unique Identifier : AIDSLINE MED/97244804; Frasca D; Pucci S; Goso C; Barattini P; Barile S; Pioli C; Doria G; Laboratory of Immunology, AMB-PRO-TOSS, ENEA CR Casaccia, Rome,; Italy. frasca@casaccia.enea.it; We investigated the production of IL-2 and IFN-gamma (Th1 type) and IL-4 (Th2 type) cytokines by mitogen-activated spleen cells from young, adult and old mice. Cytokine production was evaluated in culture supernatants by CTLL proliferation (IL-2), ELISA (IFN-gamma), CT
Increasing the immunogenicity of a trivalent influenza virus vaccine with adjuvant-active nonionic block copolymers for potential use in the elderly.: Mech Ageing Dev. 1997 Feb;93(1-3):189-203. Unique Identifier : AIDSLINE MED/97244807; Newman MJ; Todd CW; Lee EM; Balusubramanian M; Didier PJ; Katz JM; Vaxcel Inc., Norcross, GA 30092, USA.; High molecular weight nonionic block copolymers consisting of a large hydrophobic core made from repeat oxypropylene units and smaller hydrophilic blocks of oxyethylene repeat units were evaluated as adjuvants in experimental influenza virus vaccine formulations. The goal was to identify a copolymer that would increas
Malariotherapy for HIV patients.: Mech Ageing Dev. 1997 Feb;93(1-3):79-85. Unique Identifier : AIDSLINE MED/97244796; Heimlich HJ; Chen XP; Xiao BQ; Liu SG; Lu YH; Spletzer EG; Yao JL; Heimlich Institute, Cincinnati, OH, USA.; The objective of this study was to determine whether HIV patients who undergo malariotherapy experience beneficial immunological change without iatrogenic complications. In an approved, prospective study, asymptomatic. HIV-positive patients were inoculated with P. vivax malaria and the malaria infection was allowed to
[Measurement of HIV-RNA in blood is of great predictive value (letter)]: Lakartidningen. 1997 Apr 23;94(17):1589-90. Unique Identifier : AIDSLINE MED/97314611; Sonnerborg A; Klinisk virologi och infektionssjukdomar, Karolinska institutet,; Huddinge sjukhus.
Hidden dangers of incompletely suppressive antiretroviral therapy [comment]: Lancet. 1997 May 17;349(9063):1408-9. Unique Identifier : AIDSLINE MED/97307097; Feinberg M; Office of AIDS Research, National Institutes of Health, Bethesda,; MD 20892, USA.
Randomised trial of addition of lamivudine or lamivudine plus loviride to zidovudine-containing regimens for patients with HIV-1 infection: the CAESAR trial [see comments]: Lancet. 1997 May 17;349(9063):1413-21. Unique Identifier : AIDSLINE MED/97307101; BACKGROUND: Previous studies have shown that combination therapy with lamivudine plus zidovudine causes pronounced and sustained increases in CD4 counts and reductions in viral load in individuals infected with HIV-1. We assessed the clinical benefit of the addition of
Cytomegalovirus retinitis after initiation of highly active antiretroviral therapy.: Lancet. 1997 May 17;349(9063):1443-5. Unique Identifier : AIDSLINE MED/97307105; Jacobson MA; Zegans M; Pavan PR; O'Donnell JJ; Sattler F; Rao N; Owens S; Pollard R; Department of Medicine, University of California, San Francisco; 94110, USA. mjacobson@sfaids.ucsf.edu; BACKGROUND: In previous natural history studies and clinical trials, AIDS-related cytomegalovirus ( CMV ) retinitis has occurred primarily in patients with absolute CD4 counts of 50 cells/microL or less (0.05 x 10(9)/L) at the
Spread of HIV-1 to children in Cambodia [letter]: Lancet. 1997 May 17;349(9063):1451-2. Unique Identifier : AIDSLINE MED/97307114; Richner B; Laurent D; Sunnarat Y; Bee D; Nadal D
Getting the vaccine strategy right in HIV-1 disease [news]: Lancet. 1997 May 17;349(9063):1454. Unique Identifier : AIDSLINE MED/97307116; Rowe PM
Makers of blood products settle US HIV suits [news]: Lancet. 1997 May 17;349(9063):1459. Unique Identifier : AIDSLINE MED/97307117; Barnett AA
Seroepidemiology of measles, mumps and rubella virus infections in normal children and adults in southern Granada, Spain: response to a vaccination programme.: Microbios. 1996;88(356):143-8. Unique Identifier : AIDSLINE MED/97286564; Gutierrez J; Rodriguez M; Huber E; Munoz A; Piedrola G; Maroto C; Department of Microbiology, St Cecil's Hospital, University of; Granada, Spain.; A seroepidemiological study of measles, mumps and rubella virus infection in normal children and adults in southern Granada, Spain , and the response to a vaccination programme was carried out. Protection from the mumps and rubella virus was reduced in the group of 3 to 7 year-old ch
Father-to-mother-to-infant transmission of HIV-1: clonally transmitted isolate of infant mutates more rapidly than that of the mother and rapidly loses reactivity with neutralizing antibody.: Microbiol Immunol. 1997;41(2):131-8. Unique Identifier : AIDSLINE GENBANK; Okamoto Y; Shiosaki K; Eda Y; Tokiyoshi S; Yamaguchi Y; Gojobori T; Hachimori T; Yamazaki S; Hondo M; Laboratory of Immunology, AIDS Research Center, National; Institute of Health, Tokyo, Japan.; The sequences of the V3 loop and surrounding regions of human immunodeficiency virus type-1 from a father-to-mother-to-infant trimmer were studied and the horizontal and vertical transmissions compared. The father s virus was variable for reactivity with neutralizing antibody and sequences of the V3 loop central core
Polio vaccines and the origin of AIDS: an update [letter]: Med Hypotheses. 1997 Feb;48(2):193. Unique Identifier : AIDSLINE MED/97231308; Stricker RB; Elswood BF
Disseminated mycosis due to Scedosporium prolificans in an AIDS patient with Burkitt lymphoma.: Mycoses. 1996 Nov-Dec;39(11-12):461-5. Unique Identifier : AIDSLINE MED/97290322; Nenoff P; Gutz U; Tintelnot K; Bosse-Henck A; Mierzwa M; Hofmann J; Horn LC; Haustein UF; Department of Dermatology, University of Leipzig, Germany.; A case of fatal disseminated infection caused by the dematiaceous hyphomycete Scedosporium prolificans diagnosed post mortem is reported in a 60-year-old male patient with acquired immunodeficiency syndrome who additionally suffered from Burkitt s lymphoma. The patient was significantly granulocytopenic following aggr
Zidovudine, didanosine, or both as the initial treatment for symptomatic HIV-infected children. AIDS Clinical Trials Group (ACTG) Study 152 Team.: N Engl J Med. 1997 Jun 12;336(24):1704-12. Unique Identifier : AIDSLINE MED/97306240; Englund JA; Baker CJ; Raskino C; McKinney RE; Petrie B; Fowler MG; Pearson D; Gershon A; McSherry GD; Abrams EJ; Schliozberg J; Sullivan JL; Department of Pediatrics, Baylor College of Medicine, Houston, TX; 77030, USA.; BACKGROUND: Zidovudine has been the drug of choice for the initial treatment of symptomatic children infected with the human immunodeficiency virus (HIV). This trial was designed to assess the efficacy and safety of treatment with zidovudine alone as compared with either didanosine alone or
Comorbid Mental and Addictive Disorders: Treatment and HIV-Related Issues. Proceedings of a meeting. September 27-28, 1994.: NIDA Res Monogr. 1997;172:1-169. Unique Identifier : AIDSLINE MED/97316773
Substance use and HIV risk among people with severe mental illness.: NIDA Res Monogr. 1997;172:110-29. Unique Identifier : AIDSLINE MED/97298852; Cournos F; McKinnon K; Columbia University College of Physicians and Surgeons, New York,; NY, USA.
Depression, substance use, and sexual orientation as cofactors in HIV-1 infected men: cross-cultural comparisons.: NIDA Res Monogr. 1997;172:130-55. Unique Identifier : AIDSLINE MED/97298853; Satz P; Myers HF; Maj M; Fawzy F; Forney DL; Bing EG; Richardson MA; Janssen R; Department of Psychiatry, University of California, Los Angeles; 90024, USA.
Psychiatric symptoms, risky behavior, and HIV infection.: NIDA Res Monogr. 1997;172:156-70. Unique Identifier : AIDSLINE MED/97298854; Woody GE; Metzger D; Navaline H; McLellan T; O'Brien CP; Philadelphia VA Medical Center, USA.; These data are internally consistent and lead to several conclusions, as follows: Elevated levels of psychiatric symptoms were found among IDUs in methadone treatment as compared to their counterparts who were out of treatment. IVDUs who entered treatment had higher symptom levels than those who did not enter treatmen
Clinton sketches out his 'ethical guideposts' for modern biology [news]: Nature. 1997 May 22;387(6631):323. Unique Identifier : AIDSLINE MED/97305936; Wadman M
Ho joins Montagnier in AIDS centres project [news]: Nature. 1997 May 22;387(6631):330. Unique Identifier : AIDSLINE MED/97305941
HIV-cell fusion. The viral mousetrap [news; comment]: Nature. 1997 May 22;387(6631):346-8. Unique Identifier : AIDSLINE MED/97305945; Binley J; Moore JP
Atomic structure of the ectodomain from HIV-1 gp41 [see comments]: Nature. 1997 May 22;387(6631):426-30. Unique Identifier : AIDSLINE PDB; Weissenhorn W; Dessen A; Harrison SC; Skehel JJ; Wiley DC; Laboratory of Molecular Medicine, The Children's Hospital,; Boston, Massachusetts 02215, USA.; Fusion of viral and cellular membranes by the envelope glycoprotein gp120/gp41 effects entry of HIV-1 into the cell. The precursor, gp160, is cleaved post-translationally into gp120 and gp41 which remain non-covalently associated. Binding to both CD4 and a co-receptor leads to the conformational changes in gp120/gp41
HHV-8 and AIDS-related CNS lymphoma.: Neurology. 1997 May;48(5):1333-5. Unique Identifier : AIDSLINE MED/97297836; Morgello S; Tagliati M; Ewart MR; Department of Pathology, Mount Sinai Medical Center, New York, NY; 10029, USA.; Human herpesvirus 8 (HHV-8), the Kaposi s sarcoma (KS)-associated herpesvirus, is closely related to the transforming Epstein-Barr virus (EBV) and may be detected in AIDS-related, EBV-containing, body-cavity-based lymphomas. Accordingly, we analyzed 27 EBV-positive, AIDS-related CNS lymphomas for HHV-8 sequences. Only
Human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis and systemic lupus erythematosus.: Neurology. 1997 May;48(5):1469-70. Unique Identifier : AIDSLINE MED/97297868; Takayanagui OM; Moura LS; Petean FC; Biscaro TA; Covas DT; Osame M; Department of Neurology, Faculty of Medicine of Ribeirao Preto,; Sao Paulo University, Brazil.
Decreased absolute levels of ascorbic acid and unaltered vasoactive intestinal polypeptide receptor binding in the frontal cortex in acquired immunodeficiency syndrome.: Neurosci Lett. 1997 Mar 14;224(2):119-22. Unique Identifier : AIDSLINE MED/97241071; Everall IP; Hudson L; Kerwin RW; Department of Neuropathology, Institute of Psychiatry, London,; UK.; VIP receptor binding in the frontal cortex, a region with substantial neuronal loss, was unaltered in individuals who had died of acquired immunodeficiency syndrome (AIDS) neurotoxicity. In contrast, ascorbic acid, which suppresses human immunodeficiency virus (HIV) replication and modulates glutamatergic neuronal act
The human immunodeficiency virus type 1 (HIV-1) glycoprotein gp120 reduces the expression of neuronal nitric oxide synthase in the hippocampus but not in the cerebral cortex and medial septal nucleus of rat.: Neurosci Lett. 1997 Mar 14;224(2):75-8. Unique Identifier : AIDSLINE MED/97241060; Bagetta G; Corasaniti MT; Costa N; Berliocchi L; Finazzi-Agro A; Nistico G; Department of Pharmaco-Biology, University of Calabria, Cosenza,; Italy.; The expression of neuronal type of nitric oxide synthase (nNOS) has been studied by immunocytochemistry in the brain of rats receiving a single daily (for up to 14 consecutive days) intracerebroventricular (i.c.v.) injection of the HIV-1 recombinant protein gp 120 (100 ng/day). This treatment failed to affect nNOS exp
Science and logic on trial [editorial]: N J Med. 1997 Apr;94(4):17-8. Unique Identifier : AIDSLINE MED/97262356; Slobodien HD
What to do if you're exposed to HIV. Learn the latest about postexposure prophylaxis.: Nursing. 1997 Feb;27(2):23. Unique Identifier : AIDSLINE MED/97315560; Lubkin N
Comparison of T helper/T suppressor ratios in aqueous humor and blood samples by flow cytometric analysis.: Ophthalmologica. 1997;211(2):84-6. Unique Identifier : AIDSLINE MED/97251628; Avunduk AM; Cetinkaya K; Kapicioglu Z; Black Sea Technical University, School of Medicine, Ophthalmology; Department, Trabzon, Turkey.; This study investigates the T lymphocyte role in the production of the specific immunosuppressive environment that occupies the anterior segment of the eye. Aqueous and peripheral venous blood samples were taken from 23 patients who were operated because of senile cataract. In all samples, T helper/T suppressor ratios
Acute respiratory distress syndrome caused by respiratory syncytial virus.: Pediatr Pulmonol. 1997 Mar;23(3):176-83. Unique Identifier : AIDSLINE MED/97248711; Hammer J; Numa A; Newth CJ; Division of Pediatric Critical Care, Children's Hospital of Los; Angeles, University of Southern California School of Medicine,; USA.; Acute respiratory distress syndrome (ARDS) complicating severe respiratory syncytial virus (RSV) infection has been described in only a few infants. In contrast to the low mortality rates usually associated with RSV infections (
Duodenal leishmaniasis diagnosed by biopsy in two HIV-positive patients.: Pathol Res Pract. 1997;193(1):43-7; discussion 49-50. Unique Identifier : AIDSLINE MED/97266516; Alonso MJ; Munoz E; Picazo A; Abad MM; Gomez F; Roldan M; Laguna F; Paz JI; Lopez-Bravo A; Department of Pathology, National Cancer for Clinical Research; and Preventive Medicine (Institute of Health Carlos III), Madrid,; Spain.; We describe two cases of duodenal leishmaniasis in patients with human immunodeficiency virus (HIV) infection, diagnosed by light and electron microscopy. The patients presented nonspecific signs and symptoms, blood cultures were sterile, and serological tests for Leishmania spp. were negative. Endoscopy showed normal
Drug delivery issues in vaccine development.: Pharm Res. 1996 Dec;13(12):1777-85. Unique Identifier : AIDSLINE MED/97140600; Powell MF; Genentech, Inc., South San Francisco, California 94080, USA.; Although significant headway has been made in vaccine development, there are several delivery-related issues that must be overcome to advance tomorrow s candidate vaccines. Some of these are in the areas of: single-shot subunit vaccines, therapeutic vaccines for cancer, the use of cytokines as vaccine adjuvants, DNA-b
Localization of purine metabolizing enzymes in bovine brain microvessel endothelial cells: an enzymatic blood-brain barrier for dideoxynucleosides?: Pharm Res. 1996 Dec;13(12):1881-6. Unique Identifier : AIDSLINE MED/97140618; Johnson MD; Anderson BD; Department of Pharmaceutics and Pharmaceutical Chemistry,; University of Utah, Salt Lake City 84112, USA.; PURPOSE: The specific activities of the purine and pyrimidine metabolizing enzymes, purine nucleoside phosphorylase (PNP), adenosine deaminase (ADA) and cytidine deaminase (CDA) were determined in bovine brain microvessel endothelial cells (BBMECs), whole cerebral tissue and erythrocytes. In addition, the substrate sp
Application of the electrotopological state index to QSAR analysis of flavone derivatives as HIV-1 integrase inhibitors.: Pharm Res. 1996 Dec;13(12):1892-5. Unique Identifier : AIDSLINE MED/97140620; Buolamwini JK; Raghavan K; Fesen MR; Pommier Y; Kohn KW; Weinstein JN; Department of Medicinal Chemistry, School of Pharmacy, University; of Mississippi 38677, USA.; PURPOSE: A QSAR study based on electrotopological state (E-state) indices was conducted for a series of flavone HIV-1 integrase inhibitors to guide drug design. METHODS: E-state indices formulated to encode electronic and topological information for each skeletal atom in a molecule (Kier and Hall Pharm. Res. 7:801-807
Human immunodeficiency virus (HIV) infection and quality of life: the potential impact of Axis I psychiatric disorders in a sample of 95 HIV seropositive men.: Psychosom Med. 1997 Mar-Apr;59(2):187-92. Unique Identifier : AIDSLINE MED/97243076; Holmes WC; Bix B; Meritz M; Turner J; Hutelmyer C; Division of General Internal Medicine, University of Pennsylvania; Medical School, Philadelphia 19104-6021, USA.; holmeswc@mail.med.upenn; OBJECTIVE: The purpose of this study is to assess whether Axis I psychiatric disorders exert effects on function and well-being independent of human immunodeficiency virus (HIV)-related disease progression. METHODS: A convenience sample of 95 HIV seropositive individuals completed the Medical Outcomes Study Short Form
High dose rate Microselectron moulds for Kaposi sarcoma of the palate.: Radiother Oncol. 1997 Feb;42(2):167-70. Unique Identifier : AIDSLINE MED/97260807; Syndikus I; Vinall A; Rogers P; Spittle M; Meyerstein Institute of Oncology, Middlesex Hospital, London, UK.; PURPOSE: External beam radiotherapy for Kaposi sarcoma of the palate in HIV positive patients has often severe acute side-effects. As alternative treatment, a high dose Microselectron brachytherapy technique was developed. METHODS AND MATERIAL: A customised dental plate with afterloading tubes was made; from outlines,
Invasive thymoma with CD4+CD8+ double-positive T cell lymphocytosis.: Respiration. 1997;64(2):176-8. Unique Identifier : AIDSLINE MED/97251684; Tamaoki J; Chiyotani A; Nagai A; Konno K; First Department of Medicine, Tokyo Women's Medical College,; Japan.; Lymphocytosis in the peripheral blood is a very rare manifestation of thymoma. A 45-year-old man presented with a giant mediastinal mass involving pleural dissemination and peripheral T cell lymphocytosis. Biopsy of the mediastinal mass revealed invasive thymoma, and two-color analysis of peripheral lymphocytes showed
Disturbed gastric motor activity in patients with human immunodeficiency virus infection.: Scand J Gastroenterol. 1997 Mar;32(3):221-5. Unique Identifier : AIDSLINE MED/97239797; Konturek JW; Fischer H; van der Voort IR; Domschke W; Dept. of Medicine B, University of Munster, Germany.; BACKGROUND: Human immunodeficiency virus (HIV) infection is accompanied by a wide spectrum of disorders that affect the central and peripheral nervous system. Damage to the peripheral and central nervous system, including its autonomic division, may become manifest at any stage of the disease. METHODS: Twenty HIV-posi
RT-PCR topography of chronic psoriasis skin based on analysis of T-cell receptor B variable region gene usage.: Scand J Immunol. 1997 May;45(5):534-40. Unique Identifier : AIDSLINE MED/97303797; Ahangari G; Halapi E; Tehrani MJ; Fransson J; Hammar H; Wigzell H; Microbiology and Tumor Biology Center, Karolinska Institute,; Stockholm, Sweden.; Psoriasis is a hyperproliferative inflammatory disease and 70% of patients develop a chronic plaque form. The pathogenesis of psoriasis is not known but evidence exists that T cells play a crucial role. The T cell V-gene receptor repertoire from psoriasis skin (different layers) was compared with peripheral blood T ce
Analysis of the T-cell receptor V beta usage in monozygotic and dizygotic twins living in a Plasmodium falciparum endemic area in west Africa.: Scand J Immunol. 1997 May;45(5):541-5. Unique Identifier : AIDSLINE MED/97303798; Troye-Blomberg M; Fogdell A; el-Ghazali G; Larsson A; King MH; Sisay-Joof F; Olerup O; Grunewald J; Jepson A; Department of Immunology, Stockholm University, Sweden.; To investigate the influence of genetic and/or environmental factors in the development and shaping of the human peripheral T cell repertoire the authors studied the T-cell receptor (TCR) V beta usage in 10 adult monozygous (Mz) and nine dizygous (Dz) twin pairs living in a Plasmodium falciparum endemic area in West A
A deadline for an AIDS vaccine [news]: Science. 1997 May 23;276(5316):1184-5. Unique Identifier : AIDSLINE MED/97321972; Lawler A; Cohen J
Looking for leads in HIV's battle with immune system [news]: Science. 1997 May 23;276(5316):1196-7. Unique Identifier : AIDSLINE MED/97321978; Cohen J
Planned tests in Thailand spark debate [news]: Science. 1997 May 23;276(5316):1197. Unique Identifier : AIDSLINE MED/97321979; Cohen J
Survival benefits of pulmonary cellular activation in AIDS patients with Pneumocystis infection.: South Med J. 1997 May;90(5):531-4. Unique Identifier : AIDSLINE MED/97303751; Sharma R; Herndon B; Dew M; Rosa U; Gold 5 Pulmonary Laboratory, University of Missouri-Kansas City; School of Medicine 64108, USA.; Pneumocystis carinii pneumonia (PCP) is the most common life-threatening, opportunistic infection in patients with acquired immunodeficiency syndrome. Between 1984 and 1987, patients infected with human immunodeficiency virus (HIV) received bronchoalveolar lavages to confirm PCP diagnosis. Unstained slides containing
Primary cardiac lymphoma: initial symptoms suggestive of gastrointestinal disease.: South Med J. 1997 May;90(5):539-43. Unique Identifier : AIDSLINE MED/97303753; Nakchbandi IA; Day HJ; Department of Medicine, Abington Memorial Hospital, PA, USA.; We report a case of primary cardiac lymphoma in a patient who was not infected with human immunodeficiency virus and had symptoms suggestive of upper gastrointestinal (GI) disease. Examination revealed no GI abnormalities. Echocardiography, prompted by sudden development of congestive heart failure, revealed a large r
Anaplastic large cell lymphoma of T-cell phenotype in acquired immunodeficiency syndrome.: South Med J. 1997 May;90(5):559-66. Unique Identifier : AIDSLINE MED/97303760; Bozner P; Elkhalifa MY; Department of Pathology, University of South Alabama Medical; Center, Mobile 36617, USA.; Anaplastic large cell lymphoma (ALCL) is an uncommon non-Hodgkin s lymphoma in the general population as well as in HIV-infected patients. Ordinarily, ALCL expresses T-cell phenotype, but lymphoproliferative disorders derived from T cells rarely occur in acquired immunodeficiency s
Acute suppurative thyroiditis and necrosis of the thyroid gland: a rare endocrine manifestation of acquired immunodeficiency syndrome.: Surgery. 1997 May;121(5):593-6. Unique Identifier : AIDSLINE MED/97287070; Golshan MM; McHenry CR; de Vente J; Kalajyian RC; Hsu RM; Tomashefski JF; Department of Surgery, MetroHealth Medical Center, Case Western; Reserve University Cleveland, Ohio, USA.
Does HIV tat protein also regulate genes of other viruses present in HIV infection? [letter]: Trends Biochem Sci. 1997 Apr;22(4):115-6. Unique Identifier : AIDSLINE MED/97293618; Ferbeyre G; Bourdeau V; Cedergren R
Quantitative analysis of T helper 1, T helper 2, and inflammatory cytokine expression in patients after allogeneic bone marrow transplantation: relationship with the occurrence of acute graft-versus-host disease.: Transplantation. 1997 May 15;63(9):1307-13. Unique Identifier : AIDSLINE MED/97301625; Carayol G; Bourhis JH; Guillard M; Bosq J; Pailler C; Castagna L; Vernant JP; Pico JL; Hayat M; Chouaib S; Caignard A; CJF 94-11 INSERM Cytokines et Immunite antitumorale, Institut; Gustave-Roussy, Villejuif, France.; BACKGROUND: To further delineate the cytokine involvement in human acute graft-versus-host disease (GVHD), we analyzed cytokine expression in peripheral blood mononuclear cells (PBMC) from patients who developed acute GVHD after allogeneic bone marrow transplantation and from those who did not. METHODS: We used a high
Donor-specific cytokine production by graft-infiltrating lymphocytes induces and maintains graft vascular disease in human cardiac allografts.: Transplantation. 1997 May 15;63(9):1313-8. Unique Identifier : AIDSLINE MED/97301626; van Besouw NM; Daane CR; Vaessen LM; Mochtar B; Balk AH; Weimar W; Department of Internal Medicine I, University Hospital; Rotterdam-Dijkzigt, the Netherlands.; BACKGROUND: The development of graft vascular disease (GVD) in the allograft is a major impediment for long-term survival of heart transplant recipients. GVD may be mediated by cellular processes, in response to the transplanted heart, and regulated by cytokines. METHODS: We studied donor-specific cytokine production
Efficacy of quantitative analysis of Epstein-Barr virus-infected peripheral blood lymphocytes by in situ hybridization of EBER1 after living-related liver transplantation: a case report.: Transplantation. 1997 May 15;63(9):1363-6. Unique Identifier : AIDSLINE MED/97301635; Nakazawa Y; Chisuwa H; Ikegami T; Hashikura Y; Matsunami H; Ichikawa T; Oh-ishi T; Kawasaki S; First Department of Surgery, Shinshu University School of; Medicine, Matsumoto, Japan.; BACKGROUND: We describe a 1-year-old female who underwent living-related liver transplantation for biliary atresia and developed Epstein-Barr virus (EBV)-related posttransplant lymphoproliferative disorder. This disorder was resolved after withdrawal of immunosuppression therapy and administration of a high dose of
Bovine immunodeficiency-like virus: inactivation in milk by pasteurisation.: Vet Rec. 1997 Mar 15;140(11):275-7. Unique Identifier : AIDSLINE MED/97245274; Venables C; Lysons R; Horigan M; Stagg D; Dawson M; Virology Department, Central Veterinary Laboratory, New Haw,; Addlestone, Surrey.; Bioassay was used to determine whether bovine immunodeficiency-like virus (BIV) in milk was inactivated by pasteurisation. Three groups of three calves were inoculated with virus (BIV isolate FL112), milk seeded with virus and milk seeded with virus that had been pasteurised before inoculation, respectively. Seroconve
[A modern approach to developing anti-HIV vaccines]: Vopr Virusol. 1997 Mar-Apr;42(2):50-3. Unique Identifier : AIDSLINE MED/97290127; Sergeev OV
[False-positive reactions in laboratory diagnosis of Lassa, Marburg, and Ebola viral hemorrhagic fevers and AIDS]: Vopr Virusol. 1997 Mar-Apr;42(2):66-70. Unique Identifier : AIDSLINE MED/97290132; Vladyko AS; Zaitseva VN; Trofimov NM; Shkolina TV; Scheslenok EP; Boshchenko IuA; Petkevich AS; Sera of normal subjects and AIDS patients living in Minsk and Odessa were tested for antibodies to hazardous viral infections Lassa, Marburg, and Ebola. Four to 16% of examinees were seropositive to Ebola virus, 0.8 to 2.3% to Lassa, and up to 0.8% to Marburg virus. Common B-epitopes were found in viruses belonging to
[Features of adult T-cell leukemia virus reproduction in B-cell lines and it's interaction with the Epstein-Barr herpesvirus]: Vopr Virusol. 1997 Mar-Apr;42(2):77-81. Unique Identifier : AIDSLINE MED/97290135; Iakovleva LS; Pavlish OA; Syrtsev AV; Galetskii SA; Dushen'kina TE; Gurtsevich VE; Interaction between human T-cell leukemia virus (HTLV) with B cells and Epstein-Barr virus (EBV) was studied by immunoblotting, immunofluorescence, virus isolation in permissive T-cell cultures, and polymerase chain reaction (PCR). HTLV-1 in vitro infects the B-cell cultures containing EBV but not EBV-negative cell li
HIV and human endogenous retroviruses: an hypothesis with therapeutic implications.: Acta Biochim Pol. 1996;43(4):583-92. Unique Identifier : AIDSLINE MED/97258020; McIntosh EM; Haynes RH; Department of Biology, York University, Toronto, Ontario, Canada.; The enzyme dUTP pyrophosphatase (dUTPase, EC 3.6.1.23) is essential for cellular DNA replication and cell viability by virtue of its role in reducing the availability of dUTP as a substrate for DNA polymerases. Several members of the onco- and lentivirus families of retroviruses encode dUTPases and mutant strains of t
Pneumocystis carinii pneumonia. Review of 32 cases in immunocompromised hosts.: Acta Clin Belg. 1997;52(1):19-26. Unique Identifier : AIDSLINE MED/97240011; de Hoon JN; Peetermans WE; Bobbaers HJ; Dienst Inwendige Ziekten U.Z. Gasthuisberg, K.U. Leuven.; The records of patients in whom Pneumocystis carinii pneumonia (PCP) was diagnosed between January 1989 and December 1991 were reviewed. Thirty-two patients--all immunocompromised--were included in the study: 41% were HIV-positive and 59% HIV-negative. In 23 patients (72%) concomitant pathogens were isolated, most fre
Long survival of a patient with AIDS in spite of previous Rhodococcus equi infection [letter]: Acta Clin Belg. 1997;52(1):50. Unique Identifier : AIDSLINE MED/97240016; Schneider E; Farber CM; Struelens MJ; Van Vooren JP
Effect of zidovudine on blood composition of the pregnant and fetal baboon.: Am J Obstet Gynecol. 1997 May;176(5):1095-8. Unique Identifier : AIDSLINE MED/97308983; Daniel SS; Garland M; Stark RI; Myers MM; Tropper PJ; Department of Anesthesiology, Columbia College of Physicians and; Surgeons, New York, NY 10032, USA.; OBJECTIVE: Our purpose was to assess the effect of intravenous zidovudine on placental function and fetal well-being. STUDY DESIGN: Eighteen chronically instrumented third-trimester pregnant baboons and their fetuses were studied after 4- to 48-hour infusions of zidovudine to 14 mothers (0.8 to 2.0 mg/kg/hr) and 6 fet
Pulmonary mechanical and immunologic dysfunction in a murine model of AIDS.: Am J Physiol. 1997 Apr;272(4 Pt 1):L699-706. Unique Identifier : AIDSLINE MED/97287816; Hartsfield CL; Lipke D; Lai YL; Cohen DA; Gillespie MN; Department of Microbiology and Immunology, College of Pharmacy,; University of Kentucky, Lexington 40536-0082, USA.; Human immunodeficiency virus-infected patients occasionally exhibit alveolar septal wall thickening and decreases in gas diffusion capacity, but the mechanism underlying these abnormalities is unknown. The present study evaluated septal wall thickness and gas exchange properties in a murine model of the acquired immun
Suppression of the immune system by oral glucocorticoid therapy in bronchial asthma [see comments]: Allergy. 1997 Feb;52(2):144-54. Unique Identifier : AIDSLINE MED/97259398; Oehling AG; Akdis CA; Schapowal A; Blaser K; Schmitz M; Simon HU; Swiss Institute of Allergy and Asthma Research (SIAF), University; of Zurich, Davos, Switzerland.; The effect of systemic glucocorticoid therapy on immune parameters was studied in patients with bronchial asthma. Patients were divided into two groups: 1) those receiving oral glucocorticoid; 2) control patients who did not receive systemic glucocorticoid treatment. The glucocorticoid dose varied between 5 and 70 mg
Monitoring plasma HIV-1 RNA levels in addition to CD4+ lymphocyte count improves assessment of antiretroviral therapeutic response. ACTG 241 Protocol Virology Substudy Team [see comments]: Ann Intern Med. 1997 Jun 15;126(12):929-38. Unique Identifier : AIDSLINE MED/97315710; Hughes MD; Johnson VA; Hirsch MS; Bremer JW; Elbeik T; Erice A; Kuritzkes DR; Scott WA; Spector SA; Basgoz N; Fischl MA; D'Aquila RT; Harvard School of Public Health, Massachusetts General Hospital,; Boston 02114-2698, USA.; BACKGROUND: CD4+ lymphocyte counts and plasma HIV-1 RNA levels predict progression of HIV-related disease, but the relative importance of these and other virological factors in defining response to antiretroviral therapy is not yet clear. OBJECTIVE: To determine the short-term variability of plasma HIV-1 RNA level dur
Changes in plasma HIV RNA levels and CD4+ lymphocyte counts predict both response to antiretroviral therapy and therapeutic failure. VA Cooperative Study Group on AIDS [see comments]: Ann Intern Med. 1997 Jun 15;126(12):939-45. Unique Identifier : AIDSLINE MED/97315711; O'Brien WA; Hartigan PM; Daar ES; Simberkoff MS; Hamilton JD; West Los Angeles Veterans Affairs Medical Center, California,; USA.; BACKGROUND: Markers are needed for assessing response to antiretroviral therapy over time. The CD4+ lymphocyte count is one such surrogate, but it is relatively weak. OBJECTIVE: To assess the association of changes in plasma human immunodeficiency virus (HIV) RNA level and CD4+ lymphocyte count with progression to the
Plasma viral load and CD4+ lymphocytes as prognostic markers of HIV-1 infection [see comments]: Ann Intern Med. 1997 Jun 15;126(12):946-54. Unique Identifier : AIDSLINE MED/97315712; Mellors JW; Munoz A; Giorgi JV; Margolick JB; Tassoni CJ; Gupta P; Kingsley LA; Todd JA; Saah AJ; Detels R; Phair JP; Rinaldo CR Jr; School of Public Health, University of Pittsburgh, PA 15261, USA.; BACKGROUND: The rate of disease progression among persons infected with human immunodeficiency virus type 1 (HIV-1) varies widely, and the relative prognostic value of markers of disease activity has not been defined. OBJECTIVE: To compare clinical, serologic, cellular, and virologic markers for their ability to predi
Use of HIV viral load in clinical practice: back to the future [editorial; comment]: Ann Intern Med. 1997 Jun 15;126(12):983-5. Unique Identifier : AIDSLINE MED/97315718; Saag MS
Paediatric HIV infection.: Arch Dis Child. 1997 Apr;76(4):293-6. Unique Identifier : AIDSLINE MED/97308826; Sharland M; Gibb D; Tudor-Williams G; Walters S; Novelli V; Paediatric Infectious Diseases Unit, St George's Hospital,; London.
Malignancies in UK children with HIV infection acquired from mother to child transmission.: Arch Dis Child. 1997 Apr;76(4):330-3. Unique Identifier : AIDSLINE MED/97308834; Evans JA; Gibb DM; Holland FJ; Tookey PA; Pritchard J; Ades AE; Department of Paediatrics, Imperial College School of Medicine at; St Mary's, London.; By April 1995, 302 cases of vertically acquired HIV infection had been reported through the British Paediatric Association Surveillance Unit. Over 50% of these children had developed an AIDS indicator disease, including nine malignancies (seven cases of non-Hodgkin s lymphoma (NHL)
Respiratory morbidity from lymphocytic interstitial pneumonitis (LIP) in vertically acquired HIV infection.: Arch Dis Child. 1997 Apr;76(4):334-6. Unique Identifier : AIDSLINE MED/97308835; Sharland M; Gibb DM; Holland F; Paediatric Infectious Disease Unit, St George's Hospital, London.; The aim of the study was to define the respiratory morbidity caused by lymphocytic interstitial pneumonitis (LIP) in children with vertically acquired HIV infection. A retrospective case note review was performed on 95 children attending three London hospitals. Clinical and radiological evidence of LIP, acute lower re
Non-infective colitis in infancy: evidence in favour of minor immunodeficiency in its pathogenesis.: Arch Dis Child. 1997 Apr;76(4):345-8. Unique Identifier : AIDSLINE MED/97308838; Ojuawo A; St Louis D; Lindley KJ; Milla PJ; Gastroenterology Unit, Institute of Child Health, London.; Forty two infants below the age of 2 years presenting with chronic non-infective diarrhoea and shown to have histologically proved colitis were investigated over a five year period. Allergic colitis was the most common cause of colitis, accounting for 62% of the cases. Other colitides diagnosed included: non-specific
Growth ability of auxiliary gene mutants of human immunodeficiency virus types 1 and 2 in unstimulated peripheral blood mononuclear cells.: Arch Virol. 1997;142(1):177-81. Unique Identifier : AIDSLINE MED/97300862; Tokunaga K; Ishimoto A; Ikuta K; Adachi A; Institute for Virus Research, Kyoto University, Japan.; Mutational studies on the Vif, Vpr, Vpu, Vpx, and Nef genes of human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) were performed to evaluate their biological functions in natural target cells. For this purpose, replication properties of mutant viruses derived from HIV-1 NL strain and HIV-2 GH strain in unsti
Restriction of viral population by intravaginal infection of simian immunodeficiency viruses in macaque monkeys.: Arch Virol. 1997;142(1):37-51. Unique Identifier : AIDSLINE GENBANK/U27724; Enose Y; Okada M; Sata T; Ma W; Igarashi T; Ibuki K; Ido E; Hayami M; Institute for Virus Research, Kyoto University, Japan.; In order to examine whether the viral population is affected by intramucosal transmission, we analyzed the viral genotypes first detected in peripheral blood mononuclear cells (PBMCs) after intravaginal inoculation, before virus antibodies were detectable, and compared them with those in the inoculum. Three female cyn
Fulminating encephalopathy with perivenular demyelination and vacuolar myelopathy as the initial presentation of human immunodeficiency virus infection.: Arch Neurol. 1997 May;54(5):647-50. Unique Identifier : AIDSLINE MED/97296654; Silver B; McAvoy K; Mikesell S; Smith TW; Department of Neurology, University of Massachusetts Medical; Center, Worcester, USA.; OBJECTIVE: To study the neuropathologic features in a case involving a 22-year-old woman in whom a fulminating encephalopathy developed as the initial manifestation of human immunodeficiency virus (HIV) infection. DESIGN: Case report. SETTING: Tertiary care hospital. PATIENT: The patient presented with rapidly progres
Apoptosis in development and disease of the nervous system: II. Apoptosis in childhood neurologic disease.: Pediatr Neurol. 1997 Feb;16(2):93-7. Unique Identifier : AIDSLINE MED/97246070; Gelbard HA; Boustany RM; Schor NF; Division of Child Neurology, University of Rochester, New York,; USA.; The loss of cells in the human nervous system has long been known as the hallmark of incurable degenerative disease. Recent studies that began with attempts to understand cell loss during normal development have now begun to contribute to our understanding of the process of pathological cell loss. In many neurodegener
Direct cytotoxic response of human lymphocytes to porcine PHA-lymphoblasts and lymphocytes.: APMIS. 1997 Apr;105(4):290-8. Unique Identifier : AIDSLINE MED/97307264; Brevig T; Kristensen T; Department of Clinical Immunology, Odense University Hospital,; Denmark.; Transplantation of cells and organs from pigs to human beings offers potential treatment for medical conditions such as diabetes, kidney and heart failure, and Parkinson s disease. When the antibody-mediated hyperacute rejection barrier is overcome, a xenograft may not be treated as an allograft by the human immune sy
Rheumatic manifestations of infectious diseases in children.: Curr Opin Rheumatol. 1997 Jan;9(1):68-74. Unique Identifier : AIDSLINE MED/97264275; Adebajo AO; Barnsely District General Hospital, UK.; Infections associated with rheumatic diseases in children remain an important area of pediatric rheumatology. Early diagnosis and prompt treatment of septic arthritis and osteomyelitis are essential. Rheumatic fever is a significant public health problem particularly in the developing world. A variety of nonbacterial
Clinical Trials Referral Resource. Clinical trials in AIDS related malignancies.: Oncology (Huntingt). 1997 Mar;11(3):337-8, 341. Unique Identifier : AIDSLINE MED/97262918; Feigal EG; Phillips PH; Cheson BD
The role for liver biopsy in haemophiliacs infected with the hepatitis C virus.: Br J Haematol. 1997 May;97(2):343-7. Unique Identifier : AIDSLINE MED/97306132; Wong VS; Baglin T; Beacham E; Wight DD; Petrik J; Alexander GJ; Department of Medicine, University of Cambridge School of; Clinical Medicine.; Assessment of chronic hepatitis C virus infection requires a liver biopsy in most circumstances. There is a reluctance to perform liver biopsy in haemophiliacs because of a perceived risk of haemorrhage, although with adequate factor concentrate replacement in patients without factor concentrate inhibitors it should b
Human herpesvirus 8 in Kaposi's sarcoma of an HIV-negative Japanese woman with adult T-cell leukemia [letter]: Br J Haematol. 1997 May;97(2):507-8. Unique Identifier : AIDSLINE MED/97306161; Daibata M; Kawachi Y; Miyoshi I
Commentary on Joffe (1996) AIDS research and prevention: a social representation approach.: Br J Med Psychol. 1997 Mar;70 ( Pt 1):65-73. Unique Identifier : AIDSLINE MED/97247624; Fife-Schaw C; SPERI, Department of Psychology, University of Surrey, Guildford,; UK.; Helene Joffe s (1996) article provides us with a well-presented argument detailing the failings of Knowledge, Attitude, Belief and Practice (KABP) approaches in the domain of AIDS/HIV prevention behaviours and argues that the Theory of Social Representations (Moscovici, 1984) offers a useful alternative perspective. I
Juxtaposing positivist and non-positivist approaches to social scientific AIDS research: reply to Fife-Schaw's commentary.: Br J Med Psychol. 1997 Mar;70 ( Pt 1):75-83. Unique Identifier : AIDSLINE MED/97247625; Joffe H; Department of Psychology, University College London, UK.; Many academics argue that the AIDS-related debates are hackneyed, that the area has been oversubscribed and that most AIDS research merely reinvents the wheel. I disagree. The energy which continues to be dedicated to the area is invaluable not only in terms of the theoretical and preventive terrain which is still to
STRUCTURELAB: a heterogeneous bioinformatics system for RNA structure analysis.: J Mol Graph. 1996 Aug;14(4):194-205, 222-4. Unique Identifier : AIDSLINE MED/97231238; Shapiro BA; Kasprzak W; Image Processing Section, National Cancer Institute, Frederick; Cancer Research and Development Center, National Institutes of; Health, Maryland 21702-1201, USA.; STRUCTURELAB is a computational system that has been developed to permit the use of a broad array of approaches for the analysis of the structure of RNA. The goal of the development is to provide a large set of tools that can be well integrated with experimental biology to aid in the process of the determination of th
Viral loads and E2/NS1 region sequences of hepatitis C virus in hepatocellular carcinoma and surrounding liver.: Korean J Intern Med. 1997 Jan;12(1):28-33. Unique Identifier : AIDSLINE MED/97302787; Park CK; Park TR; Kim YB; Kim HY; Yoo JY; Kim CH; Choo SH; Cho JM; Department of Internal Medicine, College of Medicine, Hallym; University, Seoul, Korea.; OBJECTIVES: Numerous epidemiologic data have documented that chronic infection by hepatitis C virus (HCV) is a major risk factor for the development of hepatocellular carcinoma (HCC). But the molecular mechanism underlying these strong epidemiologic associations between HCV and HCC has not be elucidated. We observed t
Adolescent heterosexual experience: a new typology.: J Adolesc Health. 1997 Mar;20(3):179-86. Unique Identifier : AIDSLINE MED/97221972; Miller KS; Clark LF; Wendell DA; Levin ML; Gray-Ray P; Velez CN; Webber MP; Division of HIV/AIDS Prevention, Centers for Disease Control and; Prevention, Atlanta, Georgia 30333, USA.; PURPOSE: The purpose of this paper is to define a typology that encompasses the full range of adolescent heterosexual behavior; to compare the usefulness of the new typology with that of the traditional dichotomy of sexually active / sexually inactive for understanding sexual behavior among adolescents; and to deter
Effectiveness of the 40 adolescent AIDS-risk reduction interventions: a quantitative review.: J Adolesc Health. 1997 Mar;20(3):204-15. Unique Identifier : AIDSLINE MED/97221975; Kim N; Stanton B; Li X; Dickersin K; Galbraith J; Center for Minority Health Research, University of Maryland,; Baltimore 21201, USA.; OBJECTIVE: (1) To review evaluations of Acquired Immunodeficiency Syndrome (AIDS) prevention interventions targeting adolescents to determine whether these efforts have been effective in reducing risk behaviors. (2) To examine the relation between intervention design issues and outcomes measures. METHOD: A systematic
HIV testing, behaviors, and knowledge among adolescents at high risk.: J Adolesc Health. 1997 Mar;20(3):216-25. Unique Identifier : AIDSLINE MED/97221976; Rotheram-Borus MJ; Gillis JR; Reid HM; Fernandez MI; Gwadz M; Department of Psychiatry, UCLA 90024, USA.; PURPOSE: We examined HIV testing behavior and its predictors among adolescents considered at high risk for HIV. METHODS: Self-reports of HIV testing, knowledge, attitudes, and high-risk acts were examined among 272 adolescents aged 13-23 years (M = 18.7; SD = 2.3) attending community-based agencies that serve youth at
Ocular manifestations in adult T-cell leukemia/lymphoma.: Ann Hematol. 1997 Apr;74(4):163-8. Unique Identifier : AIDSLINE MED/97317516; Shibata K; Shimamoto Y; Nishimura T; Okinami S; Yamada H; Miyahara M; Department of Internal Medicine, Saga Medical School, Japan.; Ocular manifestations of adult T-cell leukemia/lymphoma (ATL) are rare events. However, several ocular lesions which resulted from human T-cell leukemia virus type I (HTLV-I) infection have been reported, including direct infiltration of ATL cells, cytomegalovirus retinitis, and HT
Evaluation of cationic liposomes for delivery of diphtheria toxin A-chain gene to cells infected with bovine leukemia virus.: J Vet Med Sci. 1997 Mar;59(3):169-74. Unique Identifier : AIDSLINE MED/97256144; Lee JT; Watarai S; Kakidani H; Onuma M; Zhao DD; Yasuda T; Department of Cell Chemistry, Okayama University Medical School,; Japan.; We investigated whether cationic liposomes are efficient at delivering the gene for diphtheria toxin A-chain (DT-A) under the control of the long terminal repeat (LTR) of bovine leukemia virus (BLV) (pLTR-DT) into BLV-infected cells and are also suitable for in vivo use. The transfection activity of the cationic lipos
Human immunodeficiency virus (HIV) RNA in plasma as the preferred target for therapy in patients with HIV infection: a critique.: Clin Infect Dis. 1997 Feb;24(2):116-22. Unique Identifier : AIDSLINE MED/97268784; Fessel WJ; HIV Research Unit, Kaiser Permanente, San Francisco, California; 94115, USA.; The measurement of human immunodeficiency virus (HIV) RNA copies in plasma establishes the prognosis for HIV-infected patients and provides a rapid method of assessing the efficacy of a new antiretroviral agent. However, whether or not periodic measurement of plasma HIV RNA will aid physicians in the long-term treatme
Patterns of fluconazole susceptibility in isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis due to Candida albicans.: Clin Infect Dis. 1997 Feb;24(2):124-30. Unique Identifier : AIDSLINE MED/97268786; Laguna F; Rodriguez-Tudela JL; Martinez-Suarez JV; Polo R; Valencia E; Diaz-Guerra TM; Dronda F; Pulido F; Servicio de Enfermedades Infecciosas, Centro de Investigacion; Clinica, Madrid, Spain.; We evaluated 119 episodes of oropharyngeal candidiasis due to C. albicans to study the patterns of fluconazole susceptibility of the isolates and the characteristics of the patients and to confirm the correlation between fluconazole susceptibility of isolates and therapeutic outcome. Sixty-one isolates were considered
Cryptococcal meningitis in Durban, South Africa: a comparison of clinical features, laboratory findings, and outcome for human immunodeficiency virus (HIV)-positive and HIV-negative patients.: Clin Infect Dis. 1997 Feb;24(2):131-4. Unique Identifier : AIDSLINE MED/97268787; Moosa MY; Coovadia YM; Department of Medicine, University of Natal Medical School and; King Edward VIII Hospital, Congella, South Africa.; We retrospectively compared the clinical manifestations, laboratory features, and outcome of cryptococcal meningitis in 44 human immunodeficiency virus (HIV)-positive and 21 HIV-negative patients in Durban, South Africa , and contrasted our findings with those in the developed worl
Pneumonia and bacteremia due to Mycobacterium celatum masquerading as Mycobacterium xenopi in patients with AIDS: an underdiagnosed problem?: Clin Infect Dis. 1997 Feb;24(2):140-3. Unique Identifier : AIDSLINE MED/97268789; Zurawski CA; Cage GD; Rimland D; Blumberg HM; Division of Infectious Diseases of Emory University School of; Medicine, Grady Memorial Hospital, Atlanta, Georgia 30303, USA.; A newly described species of mycobacteria, Mycobacterium celatum, has rarely been reported as a cause of localized and disseminated human disease and can easily be misidentified as Mycobacterium xenopi when identification is based on biochemical testing alone. We report two cases of pneumonia and bacteremia due to M.
Isolation of Mycobacterium celatum from patients infected with human immunodeficiency virus.: Clin Infect Dis. 1997 Feb;24(2):144-7. Unique Identifier : AIDSLINE MED/97268790; Piersimoni C; Tortoli E; de Lalla F; Nista D; Donato D; Bornigia S; De Sio G; Department of Clinical Microbiology, Umberto I-Torrette Hospital,; Ancona, Italy.; Mycobacterium celatum is a recently described, slowly growing mycobacterium of still undefined clinical relevance. A retrospective study of seven patients was conducted to further elucidate the clinical presentation and prognosis of infection due to M. celatum in patients with AIDS. Three patients had an exclusively p
Vaginal colonization or infection with Candida albicans in human immunodeficiency virus-infected women during pregnancy and during the postpartum period. Women and Infants Transmission Study Group.: Clin Infect Dis. 1997 Feb;24(2):201-10. Unique Identifier : AIDSLINE MED/97268800; Burns DN; Tuomala R; Chang BH; Hershow R; Minkoff H; Rodriguez E; Zorrilla C; Hammill H; Regan J; Pediatric, Adolescent, and Maternal AIDS Branch, National; Institute of Child Health and Human Development, National; Institutes of Health, Bethesda, Maryland 20892-7510, USA.; We evaluated the relationship between immunologic status and vaginal colonization or infection with Candida albicans for 605 women enrolled in a multicenter, prospective cohort study of mother-to-infant transmission of human immunodeficiency virus type 1 (HIV-1). A low CD4+ lymphocyte level ( or = 14%, whic
Mycobacterium xenopi: innocent bystander or emerging pathogen? [see comments]: Clin Infect Dis. 1997 Feb;24(2):226-32. Unique Identifier : AIDSLINE MED/97268804; Jiva TM; Jacoby HM; Weymouth LA; Kaminski DA; Portmore AC; Department of Internal Medicine, University of Rochester School; of Medicine and Dentistry, New York, USA.; Mycobacterium xenopi is a recognized cause of smoldering pulmonary disease in patients with chronic lung disease. This organism is frequently isolated from respiratory specimens from individuals infected with human immunodeficiency virus (HIV) and is often considered nonpathogenic. Cases of pulmonary and disseminated
Intrathoracic Mycobacterium avium complex infection in immunocompetent children: case report and review.: Clin Infect Dis. 1997 Feb;24(2):250-3. Unique Identifier : AIDSLINE MED/97268808; Fergie JE; Milligan TW; Henderson BM; Stafford WW; Infectious Diseases Service, Driscoll Children's Hospital, Corpus; Christi, Texas 78411, USA.; Mycobacterium avium complex (MAC) infection is a rarely recognized cause of intrathoracic infection in immunocompetent children. The incidence of this disease is unknown but is likely underestimated among children in whom MAC infection is not usually considered. An increase in the number of cases of MAC infection in a
Pulmonary gangrene secondary to pneumococcal pneumonia in a patient with AIDS.: Clin Infect Dis. 1997 Feb;24(2):268-9. Unique Identifier : AIDSLINE MED/97268813; Collazos J; Fernandez A; Mayo J; Martinez E; Section of Infectious Diseases, Hospital de Galdakao, Vizcaya,; Spain.
Use of telephone medicine for the care of patients with human immunodeficiency virus infection or AIDS: comparison of a private infectious disease practice with a university clinic practice.: Clin Infect Dis. 1997 Feb;24(2):269-70. Unique Identifier : AIDSLINE MED/97268814; Morrison RE; Wan JY; Dorko CS; Sargent SJ; Land MA; Bronze CB; Department of Medicine, University of Tennessee College of; Medicine, Memphis 38103, USA.
Noncandidal fungal peritonitis in patients with AIDS: report of three cases and review.: Clin Infect Dis. 1997 Feb;24(2):279-80. Unique Identifier : AIDSLINE MED/97268822; Spindel SJ; Lacke CE; Pellegrino CR; Graviss EA; Hamill RJ; Veterans Affairs Medical Center, Houston, Department of Medicine,; Baylor College of Medicine, Texas 77030-4211, USA.
Primary human immunodeficiency virus type 1 infection may vary in time, place, and person [letter]: Clin Infect Dis. 1997 Feb;24(2):282-3. Unique Identifier : AIDSLINE MED/97268824; Hudson CP; Levett PN
Expression of the human immunodeficiency virus type-1 coreceptors CXCR-4 (fusin, LESTR) and CKR-5 in CD34+ hematopoietic progenitor cells.: Blood. 1997 May 15;89(10):3522-8. Unique Identifier : AIDSLINE MED/97304293; Deichmann M; Kronenwett R; Haas R; Klinische Kooperationseinheit Molekulare Hamatologie/Onkologie,; Deutsches Krebsforschungszentrum, Heidelberg, Germany.; CD34+ hematopoietic progenitor cells were assessed for mRNA expression of the human immunodeficiency virus type-1 (HIV-1) coreceptors CXCR-4, also termed fusin or LESTR, and CKR-5, also called CC-CKR-5 or CCR-5. The CD34+ cells were obtained from leukapheresis products of 17 patients after granulocyte colony-stimulati
A multicenter controlled, randomized, open trial of interferon alpha2b treatment of anti-human immunodeficiency virus-negative hemophilic patients with chronic hepatitis C. Hepatitis Study Group of the Association of Italian Hemophilia Centers.: Blood. 1997 May 15;89(10):3529-33. Unique Identifier : AIDSLINE MED/97304294; Rumi MG; Santagostino E; Morfini M; Gringeri A; Tagariello G; Chistolini A; Pontisso P; Tagger A; Colombo M; Mannucci PM; Institute of Internal Medicine, University of Milan, IRCCS; Maggiore Hospital, Italy.; There is limited information about the long-term efficacy of prolonged therapy (more than 6 months) with interferon alpha in hemophilic patients with chronic hepatitis C who are not coinfected with the human immunodeficiency virus (HIV-1). One hundred and seven hemophiliacs were randomly assigned to 3 million U of int
Functional characterization and modulation of cytokine production by CD8+ T cells from human immunodeficiency virus-infected individuals.: Blood. 1997 May 15;89(10):3672-81. Unique Identifier : AIDSLINE MED/97304309; Maggi E; Manetti R; Annunziato F; Cosmi L; Giudizi MG; Biagiotti R; Galli G; Zuccati G; Romagnani S; Department of Clinical Immunology, Istituto di Medicina Interna e; Immunoallergologia, University of Florence, Firenze, Italy.; CD8+ T-cell clones were generated from peripheral blood mononuclear cells (PBMC) of three human immunodeficiency virus (HIV)-seronegative individuals and six HIV-seropositive individuals and assessed for their cytokine secretion profile, cytolytic potential, and chemokine production. While the great majority of CD8+ T
Distinctions between CD8+ and CD4+ T-cell regenerative pathways result in prolonged T-cell subset imbalance after intensive chemotherapy.: Blood. 1997 May 15;89(10):3700-7. Unique Identifier : AIDSLINE MED/97304312; Mackall CL; Fleisher TA; Brown MR; Andrich MP; Chen CC; Feuerstein IM; Magrath IT; Wexler LH; Dimitrov DS; Gress RE; Laboratory of Mathematical Biology, National Cancer Institute,; and the Clinical Pathology Department, National Institutes of; Health, Bethesda, MD 20892-1928, USA.; Rapid recovery of CD4+ T cells after intensive chemotherapy is limited by an age-dependent decline in thymopoiesis. Here we sought to determine whether similar limitations exist for CD8+ T-cell regeneration. After intensive chemotherapy, CD8+ T cells had a faster effective doubling time than CD4+ T cells (median, 12.6
Frequent mutation of the 5' noncoding region of the BCL-6 gene in acquired immunodeficiency syndrome-related non-Hodgkin's lymphomas.: Blood. 1997 May 15;89(10):3755-62. Unique Identifier : AIDSLINE MED/97304318; Gaidano G; Carbone A; Pastore C; Capello D; Migliazza A; Gloghini A; Roncella S; Ferrarini M; Saglio G; Dalla-Favera R; Dipartimento di Scienze Mediche, Universita di Torino, Novara,; Italy.; Acquired immunodeficiency syndrome (AIDS)-related non-Hodgkin s lymphomas (AIDS-NHL), a major source of morbidity and mortality among human immunodeficiency virus (HIV)-infected individuals, are derived from B cells and are classified into two major categories, Burkitt s lymphoma (BL) and diffuse large cell lymphoma (
Cytomegalovirus-specific T-cell immunity in recipients of autologous peripheral blood stem cell or bone marrow transplants.: Blood. 1997 May 15;89(10):3873-9. Unique Identifier : AIDSLINE MED/97304333; Reusser P; Attenhofer R; Hebart H; Helg C; Chapuis B; Einsele H; Department of Medicine, University Hospital, Basel, Switzerland.; The cytomegalovirus ( CMV )-specific CD8+ cytotoxic T-lymphocyte (CTL) and CD4+ T-helper cell (Th) functions were characterized in 15 CMV seropositive recipients of autologous peripheral blood stem cell or bone marrow transplan
Cytokine production regulating Th1 and Th2 cytokines in hemophagocytic lymphohistiocytosis.: Blood. 1997 Jun 1;89(11):4100-3. Unique Identifier : AIDSLINE MED/97309436; Osugi Y; Hara J; Tagawa S; Takai K; Hosoi G; Matsuda Y; Ohta H; Fujisaki H; Kobayashi M; Sakata N; Kawa-Ha K; Okada S; Tawa A; Department of Pediatrics, Osaka University Hospital, Suita,; Japan.; Hemophagocytic lymphohistiocytosis (HLH) is caused by the hyperactivation of T cells and macrophages. The clinical characteristics associated with this disease result from overproduction of Th1 cytokines including interferon-gamma (IFN-gamma), interleukin-2 ( IL-2 ), and
Synthesis and mass spectrometric behavior of some new nucleosides as potential anti-HIV agents.: Rapid Commun Mass Spectrom. 1997;11(7):774-80. Unique Identifier : AIDSLINE MED/97304683; Fadda AM; Podda G; Teijeira M; Uriarte E; Favretto D; D'Alpaos M; Traldi P; Dipartimento Farmaco Chimico Tecnologico, Cagliari, Italy.; The electron-impact (EI) mass spectrometric behaviour of a series of 8-aza-purines derivatized with hydroxymethylcyclopentane and exhibiting cis-trans isomerization in the cyclopentane ring has been studied in detail with the aid of metastable-ion data. Specific fragmentation processes, present in both EI and mass ana
Extracorporeal photochemotherapy induces a significant increase in CD36+ circulating monocytes in patients with mycosis fungoides.: Dermatology. 1997;194(2):107-10. Unique Identifier : AIDSLINE MED/97248228; Fimiani M; Rubegni P; Pimpinelli N; Mori M; De Aloe G; Andreassi L; Department of Dermatology, University of Siena, Italy.; BACKGROUND: In patients with Sezary syndrome undergoing extracorporeal photochemotherapy it is currently thought that photodamage of a congruent number of pathogenic circulating T cells is a necessary condition for a specific anticlonal response to be induced against these cells by the immune system. However other mec
Kaposi's sarcoma during immunosuppressive therapy for atopic dermatitis.: Dermatology. 1997;194(2):180-2. Unique Identifier : AIDSLINE MED/97248244; Vandercam B; Lachapelle JM; Janssens P; Tennstedt D; Lambert M; Division of General Internal Medicine, St Luc University; Hospital, Louvain Medical School, Brussels, Belgium.; We describe an HIV-negative homosexual man who developed Kaposi s sarcoma (KS). He had CD4 lymphocytopenia during azathioprine and topical corticosteroid therapy for atopic dermatitits (AD). KS was observed after only 2 months of immunosuppressive therapy. No regression was observed despite discontinuation of immunosu
Two cases of localized B-cell lymphoma in the acquired immunodeficiency syndrome.: Dermatology. 1997;194(2):185-7. Unique Identifier : AIDSLINE MED/97248246; Castanet J; Lacour JP; Taillan B; Perrin C; Garnier G; Ortonne JP; Department of Dermatology, University of Nice, France.; We report 2 cases of localized B-cell non-Hodgkin lymphoma occurring on the face in AIDS patients. The tumors were limited to the skin and bone, without other involvement. They were characterized by an aggressive local behavior that caused infectious and compressive complications and resulted in fatal outcome. Knowled
Eruptive dermatofibromas in AIDS patients: a form of mycobacteriosis? [letter]: Dermatology. 1997;194(2):197. Unique Identifier : AIDSLINE MED/97248251; Silvestre JF; Betloch I; Jimenez MJ
Current clinical issues in the management of herpes simplex virus infections in patients with HIV.: Dermatology. 1997;194(2):93-7. Unique Identifier : AIDSLINE MED/97248225; Conant M; University of California Medical Center, San Francisco 94117,; USA.; BACKGROUND: A recent study done in Baltimore showed HSV-2 seroprevalence of 81% among 64 HIV-positive homosexual or bisexual men. OBJECTIVE: Our purpose was to examine HSV-2 as a risk factor for acquiring HIV infection, as well as to explore the possibility that acyclovir , an ag
[Phenotype of lymphocytes in bronchoalveolar lavage and peripheral blood with different clinical presentations of sarcoidosis]: Pneumonol Alergol Pol. 1996;64 Suppl 1:52-8. Unique Identifier : AIDSLINE MED/97279266; Kieszko R; Michnar M; Milanowski J; Fafrowicz B; Koktysz M; Rolinski J; Dmoszynska A; Katedry i Kliniki Chorob Pluc i Gruzlicy, Akademii Medycznej w; Lublinie.; The aim of this study was to investigate the relationship between the bronchoalveolar cell counts, the phenotypic characteristics of bronchoalveolar lavage and peripheral lymphocytes and the clinical manifestation of sarcoidosis. 24 patients with sarcoidosis of the lung were examined. Patients were divided into groups
Global distribution of the CCR5 gene 32-basepair deletion.: Nat Genet. 1997 May;16(1):100-3. Unique Identifier : AIDSLINE MED/97285131; Martinson JJ; Chapman NH; Rees DC; Liu YT; Clegg JB; MRC Molecular Haematology Unit, John Radcliffe Hospital,; Headington, Oxford, UK. jmartins@helix.hgen.pitt.edu; A mutant allele of the beta-chemokine receptor gene CCR5 bearing a 32-basepair (bp) deletion (denoted delta ccr5) which prevents cell invasion by the primary transmitting strain of HIV-1 has recently been characterized. Homozygotes for the mutation are resistant to infection, even after repeated high-risk exposures, b
Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases.: Nat Genet. 1997 May;16(1):109. Unique Identifier : AIDSLINE MED/97285133; Reifnyder C; Lowell J; Clarke A; Pillus L
The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation.: Nat Genet. 1997 Jun;16(2):161-70. Unique Identifier : AIDSLINE MED/97315822; Ye BH; Cattoretti G; Shen Q; Zhang J; Hawe N; de Waard R; Leung C; Nouri-Shirazi M; Orazi A; Chaganti RS; Rothman P; Stall AM; Pandolfi PP; Dalla-Favera R; Department of Pathology, Columbia University, New York, New York; 10032, USA.; Structural alterations of the promoter region of the BCL-6 proto-oncogene represent the most frequent genetic alteration associated with non-Hodgkin lymphoma, a malignancy often deriving from germinal-centre B cells. The BCL-6 gene encodes a zinc-finger transcriptional repressor normally expressed in both B cells and
[Treatment of HIV infection (orientation--February 1996)]: Rev Assoc Med Bras. 1996 Apr-Jun;42(2):98-100. Unique Identifier : AIDSLINE MED/97264653; Amato Neto V; dos Santos SS; Departamento de Doencas Infecciosas e Parasitarias.
Who owns AIDS? [editorial] [see comments]: Br J Hosp Med. 1997 Mar 5-18;57(5):186-7. Unique Identifier : AIDSLINE MED/97319700; Pinching AJ
Who owns AIDS? [letter; comment]: Br J Hosp Med. 1997 Mar 5-18;57(5):228. Unique Identifier : AIDSLINE MED/97319712; Shahmanesh M
The chemotactic activity of T-lymphocytes in response to interleukin 8 is significantly decreased in patients with psoriasis and atopic dermatitis.: Exp Dermatol. 1996 Dec;5(6):334-40. Unique Identifier : AIDSLINE MED/97180619; Zheng M; Sun G; Mrowietz U; Department of Dermatology, Second Affiliated Hospital, Zhejiang; Medical University, Hangzhou, PR China.; Involvement of T-lymphocytes in the pathogenesis of psoriasis and atopic dermatitis is well established. The question arises as to whether not only tissue infiltrating but also circulating T-lymphocytes are involved in the disease process. Therefore we sought to determine whether T-lymphocytes from patients with psori
Effect of slow release IL-12 and IL-10 on inflammation, local macrophage function and the regional lymphoid response during mycobacterial (Th1) and schistosomal (Th2) antigen-elicited pulmonary granuloma formation.: Inflamm Res. 1997 Mar;46(3):86-92. Unique Identifier : AIDSLINE MED/97253277; Chensue SW; Warmington K; Ruth JH; Kunkel SL; Department of Pathology and Laboratory Medicine, Veterans Affairs; Medical Center, Ann Arbor, MI 48105, USA.; OBJECTIVE AND DESIGN: This study examines the local and regional effects of exogenously administered interleukins 10 (IL-10) and 12 (IL-12) on pulmonary granulomas mediated by Th1/type 1-(IFN-gamma) and Th2/type 2-(IL-4, IL-5 cytokines. MATERIALS AND TREATMENTS: Granulomas (GR) were induced in presensitized CBA mice b
Deposition of macromolecular coordinates resulting from crystallographic and NMR studies.: Nat Struct Biol. 1997 Mar;4(3):173-4. Unique Identifier : AIDSLINE MED/97307246; Wlodawer A; Macromolecular Structure Laboratory, NCI-Frederick Cancer; Research and Development Center, ABL-Basic Research Program; 21702, USA. wlodawer@ncifcrf.gov
A minor groove binding track in reverse transcriptase [letter]: Nat Struct Biol. 1997 Mar;4(3):194-7. Unique Identifier : AIDSLINE MED/97307252; Bebenek K; Beard WA; Darden TA; Li L; Prasad R; Luton BA; Gorenstein DG; Wilson SH; Kunkel TA
New ophthalmic manifestations of presumed rifabutin-related uveitis.: Ophthalmic Surg Lasers. 1997 Apr;28(4):321-4. Unique Identifier : AIDSLINE MED/97256242; Arevalo JF; Russack V; Freeman WR; Department of Ophthalmology, Shiley Eye Center, University of; California, a-San Diego, La Jolla 92093-0946, USA.; Rifabutin-related uveitis has been reported in AIDS patients who take a daily dose of 300 to 1800 mg of this drug. Presumed rifabutin-related uveitis is characterized by unilateral or bilateral anterior chamber inflammation with hypopyon accompanied by hyperemia, pain, photophobia, and vitritis. However, retinal manif
Nef and PAK: virulence factor and cellular accomplice.: Chem Biol. 1997 Jan;4(1):13-5. Unique Identifier : AIDSLINE MED/97223781; Trono D; Wang JK; Salk Institute for Biological Studies, La Jolla, CA 92037-1099,; USA.; The Nef protein is important in HIV replication and in AIDS pathogenesis. The finding that Nef activates a member of the PAK family of protein kinases provides new insights into the mechanisms of action of this critical virulence factor.
Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA.: Chem Biol. 1997 Feb;4(2):139-47. Unique Identifier : AIDSLINE MED/97199457; Wolff B; Sanglier JJ; Wang Y; Sandoz Research Institute, Brunner Strasse 59, A1230 Vienna,; Austria. wolff_b@a1.wienv1.sandoz.com; BACKGROUND: The human immunodeficiency virus type 1 (HIV-1) regulatory protein Rev is required for unspliced and incompletely spliced viral mRNAs to appear in the cytoplasm and thus for viral replication. Translocation of Rev from the nucleus to the cytoplasm is essential if Rev is to function. We wanted to identify i
Emergence of a methicillin-resistant Staphylococcus aureus clone related to the Brazilian epidemic clone III::B:A causing invasive disease among AIDS patients in a Brazilian hospital.: Microb Drug Resist. 1996 Winter;2(4):393-9. Unique Identifier : AIDSLINE MED/97302562; Teixeira LA; Lourenco MC; Figueiredo AM; Rockefeller University, New York, New York 10021, USA.; In a previous study we described the extensive geographic spread of a multidrug-resistant methicillin-resistant Staphylococcus aureus (MRSA) clone in hospitals located in the southern, southeastern, and northern parts of Brazil . In this study we used a set of molecular markers to d
Depression in the medically ill: management considerations.: Depress Anxiety. 1996-97;4(4):199-208. Unique Identifier : AIDSLINE MED/97309192; Evans DL; Staab J; Ward H; Leserman J; Perkins DO; Golden RN; Petitto JM; Department of Psychiatry, University of Florida College of; Medicine, Gainesville 32610, USA.; This article reviews the management of depression in three medical conditions associated with a high frequency of depression: coronary artery disease (CAD), cancer, and human immunodeficiency virus (HIV) infection. Major depression significantly increases mortality in patients with CAD. This effect of depression may b
Communicable diseases surveillance.: Commun Dis Intell. 1997 Apr 3;21(7):94-9. Unique Identifier : AIDSLINE MED/97270275
Tumor-induced suppression of antitumor reactivity and depression of TCRzeta expression in tumor-draining lymph node lymphocytes: possible relationship to the Th2 pathway.: J Immunother. 1997 Mar;20(2):111-22. Unique Identifier : AIDSLINE MED/97242384; Fu EJ; Arca MJ; Hain JM; Krinock R; Rado J; Cameron MJ; Chang AE; Sondak VK; Division of Surgical Oncology, University of Michigan Medical; Center, Ann Arbor 48109-0331, U.S.A.; T lymphocytes from tumor-draining lymph nodes (TDLN), after activation and expansion in vitro, can mediate regression of metastatic tumor in animal models. We have shown that TDLNs are subject to tumor-induced suppression that is tumor specific, T-cell mediated, and dependent on the duration of tumor growth, but the m
Concurrent induction of CD4+ and CD8+ T cells during tumor growth with antitumor reactivity in adoptive immunotherapy.: J Immunother. 1997 Mar;20(2):138-45. Unique Identifier : AIDSLINE MED/97242387; Arca MJ; Krauss JC; Aruga A; Cameron MJ; Chang AE; Division of Surgical Oncology, University of Michigan, Ann Arbor; 48109, U.S.A.; We have previously reported that the poorly immunogenic D5 melanoma transduced to secrete granulocyte-macrophage colony-stimulating factor (GM-CSF) will elicit immunity in tumor-draining lymph node (TDLN) cells after subcutaneous inoculation. After in vitro activation with anti-CD3 and interleukin-2 (
Murine postthymectomy autoimmune oophoritis develops in association with a persistent neonatal-like Th2 response.: Clin Immunol Immunopathol. 1997 Jun;83(3):230-6. Unique Identifier : AIDSLINE MED/97318974; Maity R; Caspi RR; Nair S; Rizzo LV; Nelson LM; Developmental Endocrinology Branch, NICHD, NIH, Bethesda,; Maryland 20892, USA.; Autoimmune oophoritis develops in some patients despite evidence of impaired cellular immunity. Here, using the murine postthymectomy model of autoimmune oophoritis, we investigate the hypothesis that neonatal thymectomy induces autoimmune oophoritis by disrupting the normal postnatal balance of T helper cell regulati
Patterns of geographic mobility of persons with AIDS in Canada from time of AIDS index diagnosis to death.: Clin Invest Med. 1997 Apr;20(2):77-83. Unique Identifier : AIDSLINE MED/97243822; Hogg RS; Whitehead J; Ricketts M; Heath KV; Ng E; Lalonde P; Schechter MT; British Columbia Centre for Excellence in HIV/AIDS, St. Paul's; Hospital, Vancouver, BC, Canada. bobhog@hivnet.ubc.ca; OBJECTIVE: To characterize migration patterns of persons with AIDS in Canada during the period from AIDS diagnosis to death. DESIGN: Descriptive, population-based study. SETTING: Canada. PATIENTS: Canada s AIDS Case Reporting Surveillance System (ACRSS) was linked to deaths in the
Asymptomatic oral carriage of Candida albicans in patients with HIV infection.: Clin Invest Med. 1997 Apr;20(2):85-93. Unique Identifier : AIDSLINE MED/97243823; Fong IW; Laurel M; Burford-Mason A; St. Michael's Hospital, University of Toronto, Ont.; OBJECTIVE: To assess the relationship of asymptomatic carriage of Candida albicans and clinically apparent thrush in patients with HIV infection. DESIGN: Prospective, longitudinal, controlled study. SETTING: The HIV clinic at St. Michael s Hospital, University of Toronto. PARTI
Current trends in HIV-related hospital admissions and their impact on hospital resource utilization in Ontario.: Clin Invest Med. 1997 Apr;20(2):95-101. Unique Identifier : AIDSLINE MED/97243824; Hyland MJ; Bailey G; Rawji M; Peck LL; Hyland RH; Chan CK; Department of Medicine, Wellesley Hospital, Toronto, Ont.; OBJECTIVE: To assess changes in patterns of hospital admissions, in frequency of admissions and in average length of stay (ALOS) at a tertiary HIV referral centre, and to investigate the overall impact of care for patients with HIV infection of AIDS on peer hospitals in Ontario. DESIGN: Descriptive study. PARTICIPANTS
Steady-state pharmacokinetics of delavirdine in HIV-positive patients: effect on erythromycin breath test.: Clin Pharmacol Ther. 1997 May;61(5):531-43. Unique Identifier : AIDSLINE MED/97307202; Cheng CL; Smith DE; Carver PL; Cox SR; Watkins PB; Blake DS; Kauffman CA; Meyer KM; Amidon GL; Stetson PL; College of Pharmacy, Upjohn Center for Clinical Pharmacology,; University of Michigan, Ann Arbor 48109-0504, USA.; OBJECTIVE: The steady-state kinetics of delavirdine and desisopropyldelavirdine were evaluated in human immunodeficiency virus-positive patients after escalating oral doses and after repeated oral administrations at the same dose level. STUDY DESIGN: Patients (n = 8 males) were given escalating oral doses of delavirdi
Pharmacokinetic study of the interaction between rifampin and delavirdine mesylate.: Clin Pharmacol Ther. 1997 May;61(5):544-53. Unique Identifier : AIDSLINE MED/97307203; Borin MT; Chambers JH; Carel BJ; Gagnon S; Freimuth WW; Pharmacia and Upjohn, Inc., Kalamazoo 49007, USA.; marie.t.borin@am.pnu.com; OBJECTIVE: To study the effect of rifampin (INN, rifampicin), a potent inducer of cytochrome P450, on the steady-state pharmacokinetics of delavirdine. METHODS: Twelve patients who were positive for human immunodeficiency virus, with CD4 counts ranging from 110 to 483/mm3, were randomized to two groups and studied in
Metabolism of rifabutin in human enterocyte and liver microsomes: kinetic parameters, identification of enzyme systems, and drug interactions with macrolides and antifungal agents.: Clin Pharmacol Ther. 1997 May;61(5):554-62. Unique Identifier : AIDSLINE MED/97307204; Iatsimirskaia E; Tulebaev S; Storozhuk E; Utkin I; Smith D; Gerber N; Koudriakova T; Department of Pharmacology, Ohio State University, Columbus; 43210, USA.; Biotransformation of rifabutin, an antibiotic used for treatment of tuberculosis in patients infected with the human immunodeficiency virus (HIV), and its interactions with some macrolide and antifungal agents were studied in human intestinal and liver microsomes. Both liver and enterocyte microsomes metabolized rifab
Extracorporeal bypassing of a partial obstruction of the afferent loop by percutaneous endoscopic jejunostomy and gastrostomy.: Endoscopy. 1997 Feb;29(2):142-3. Unique Identifier : AIDSLINE MED/97255834; Caca K; Bogner JR; Eibl-Eibesfeld B; Zoller WG; Medizinische Poliklinik, Klinikum Innenstadt,; Ludwig-Maximilians-Universitat Munchen, Germany.
Tuberculous bronchoesophageal fistula in a patient infected with the HIV virus.: Endoscopy. 1997 Feb;29(2):146. Unique Identifier : AIDSLINE MED/97255837; Ravera M; Gastroenterology Unit, Hoima Hospital, Kampala, Uganda.
Serum selenium, plasma glutathione (GSH) and erythrocyte glutathione peroxidase (GSH-Px)-levels in asymptomatic versus symptomatic human immunodeficiency virus-1 (HIV-1)-infection.: Eur J Clin Nutr. 1997 Apr;51(4):266-72. Unique Identifier : AIDSLINE MED/97258104; Look MP; Rockstroh JK; Rao GS; Kreuzer KA; Barton S; Lemoch H; Sudhop T; Hoch J; Stockinger K; Spengler U; Sauerbruch T; Department of General Internal Medicine, University of Bonn,; Germany.; OBJECTIVES: Antioxidant defense status was investigated in HIV-infected patients by measuring serum selenium, erythrocyte glutathione peroxidase (GSH-Px) activity, plasma thiol (-SH) and glutathione (GSH) concentrations along with the assessment of the clinical stage and surrogate markers of HIV-disease. DESIGN, SETTI
A case of malignant melanoma of the vagina during pregnancy: immunological problems.: Eur J Gynaecol Oncol. 1997;18(2):136-8. Unique Identifier : AIDSLINE MED/97259766; Zarcone R; Bellini P; Carfora E; Cardone A; Department of Obstetric and Gynecology, Second University of; Naples, Italy.; BACKGROUND: A clinical case of malignant melanoma of the vagina diagnosed during late pregnancy is described. Prompt histological examination showed a malignant melanoma at an early stage. The treatment of choice for malignant melanoma is surgical exicision. At present we are trying to associate immunological and chem
The spectrum of eye disease in children with AIDS due to vertically transmitted HIV disease: clinical findings, virology and recommendations for surveillance.: Graefes Arch Clin Exp Ophthalmol. 1997 Mar;235(3):125-9. Unique Identifier : AIDSLINE MED/97239444; Hammond CJ; Evans JA; Shah SM; Acheson JF; Walters MD; Department of Ophthalmology, St Thomas' Hospital, London, UK.; BACKGROUND: Eye disease in children infected with HIV is uncommon, but there is little information on which children require screening or surveillance and the management of those with retinitis. METHODS: We examined 12 children with symptomatic HIV disease (of a cohort of 98 HIV-positive children) using indirect ophth
[Ocular manifestations of acquired immune deficiency syndrome]: Harefuah. 1997 Apr 15;132(8):559-62. Unique Identifier : AIDSLINE MED/97298491; Averbukh E; Ticho U
Epstein-Barr virus-associated primary gastrointestinal lymphoma in non-immunocompromised patients in Korea.: Histopathology. 1997 Mar;30(3):234-42. Unique Identifier : AIDSLINE MED/97244143; Lee SS; Jang JJ; Cho KJ; Khang SK; Kim CW; Department of Pathology, Korea Cancer Center Hospital, Seoul,; Korea.; We examined 81 cases of primary gastrointestinal lymphomas in Korea, including 64 gastric lymphomas and 17 intestinal lymphomas, for EBV expression by EBER-1 in situ hybridization (ISH) and EBNA-1 PCR. In EBER-1 positive cases, we performed immunohistochemistry for latent membrane protein-1 (LMP-1) and EBV diffuse ear
Cytokine patterns in adults with AIDS.: Immunol Invest. 1997 Apr;26(3):341-50. Unique Identifier : AIDSLINE MED/97276234; Alonso K; Pontiggia P; Medenica R; Rizzo S; Institute for Advanced Studies in Medicine, Atlanta, GA; 30308-1947, USA.; BACKGROUND: It has been reported that in HIV infected patients enhanced production of IL-4 and IL-10 in response to stimulation of peripheral blood lymphocytes with phytohemagglutinin is associated with disease progression. Some have proposed that a switch from a cytokine profile associated with CD4+ Th1 predominance
An RGD containing peptide from HIV-1 Tat-(65-80) modulates protooncogene expression in human bronchoalveolar carcinoma cell line, A549.: Immunol Invest. 1997 Apr;26(3):351-70. Unique Identifier : AIDSLINE MED/97276235; el-Solh A; Kumar NM; Nair MP; Schwartz SA; Lwebuga-Mukasa JS; Department of Internal Medicine, SUNY at Buffalo School of; Medicine and Biomedical Sciences, Buffalo General Hospital 14203,; USA.; Tat (transactivator of transcription) is essential for HIV-1 replication in vivo and in vitro. Tat-(65-80), an RGD containing domain, has been shown to regulate proliferative function of a variety of cell lines, including a human adenocarcinoma cell line, A549. The exact cellular and molecular mechanisms by which thes
Repeated Chlamydia trachomatis infection of Macaca nemestrina fallopian tubes produces a Th1-like cytokine response associated with fibrosis and scarring.: Infect Immun. 1997 Jun;65(6):2175-82. Unique Identifier : AIDSLINE MED/97313144; Van Voorhis WC; Barrett LK; Sweeney YT; Kuo CC; Patton DL; Department of Medicine, University of Washington, Seattle 98195,; USA. wesley@u.washington.edu; Chlamydia trachomatis-associated female infertility and ectopic pregnancy are caused by postinflammatory fibrosis and scarring of the upper genital tract. Scarring of the upper genital tract is associated with multiple infectious episodes with C. trachomatis. To study the immune response that occurs with multiple infe
Interleukin-6 production by human monocytes stimulated with Cryptococcus neoformans components.: Infect Immun. 1997 Jun;65(6):2454-6. Unique Identifier : AIDSLINE MED/97313186; Delfino D; Cianci L; Lupis E; Celeste A; Petrelli ML; Curro F; Cusumano V; Teti G; Istituto di Microbiologia, Facolta di Medicina e Chirurgia,; Universita degli Studi di Messina, Italy.; In order to ascertain if Cryptococcus neoformans components can induce interleukin-6 (IL-6) production, we stimulated human whole blood with purified capsular products. Their potencies in stimulating IL-6 release were mannoproteins > galactoxylomannan = glucuronoxylomannan > alpha(1-3)glucan. IL-6 production was tumor
Antiviral activity of biological response modifiers in a murine model of AIDS. Requirement for augmentation of natural killer cell activity and synergy with oral AZT.: Int J Immunopharmacol. 1996 Nov;18(11):633-50. Unique Identifier : AIDSLINE MED/97244198; Black PL; McKinnon KM; Wooden SL; Ussery MA; Southern Research Institute-Frederick Research Center, MD, USA.; We employed the Rauscher murine leukemia virus (RMuLV) as a murine retrovirus model of AIDS, to test biological response modifiers (BRM) and antiviral agents for potential therapeutic activity against the human immunodeficiency virus (HIV). We examined the relationship between the augmentation of natural killer (NK) c
Chemotherapy and low-dose radiotherapy in the treatment of HIV-infected patients with carcinoma of the anal canal.: Int J Radiat Oncol Biol Phys. 1997 Mar 15;37(5):1101-5. Unique Identifier : AIDSLINE MED/97313215; Peddada AV; Smith DE; Rao AR; Frost DB; Kagan AR; Kaiser Permanente Medical Center, Los Angeles, CA, USA.; PURPOSE: To determine the efficacy and tolerance of a standardized protocol of chemotherapy and low-dose radiotherapy in the treatment of anal cancer in human immunodeficiency virus (HIV)-infected patients. METHODS AND MATERIALS: Between 1987 and 1995, eight HIV-positive patients with squamous cell carcinoma of the an
Protein kinase C-mediated phosphorylation of HIV-I nef in human cell lines.: J Biol Chem. 1997 May 9;272(19):12289-94. Unique Identifier : AIDSLINE MED/97284694; Coates K; Cooke SJ; Mann DA; Harris MPG; MRC Retrovirus Research Laboratory, Department of Veterinary; Pathology, University of Glasgow, Glasgow G61 1QH, Scotland,; United Kingdom.; Stable human cell lines expressing the human immunodeficiency virus type I (HIV-I) Nef protein from inducible promoters were used to analyze the phosphorylation status of Nef in vivo. Nef phosphorylation in both HeLa and Jurkat cells was stimulated by phorbol ester treatment. Phosphoamino acid analysis revealed a pred
Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5.: J Biol Chem. 1997 May 9;272(19):12495-504. Unique Identifier : AIDSLINE MED/97284722; Nibbs RJB; Wylie SM; Pragnell IB; Graham GJ; Cancer Research Campaign Laboratories, The Beatson Institute for; Cancer Research, Garscube Estate, Switchback Road, Bearsden,; Glasgow G61 1BD, United Kingdom.; The beta-chemokine macrophage inflammatory protein-1alpha (MIP-1alpha) is chemotactic for many hemopoietic cell types and can inhibit hemopoietic stem cell (HSC) proliferation, effects mediated through G-protein coupled heptahelical receptors. We have isolated cDNAs for seven chemokine receptors, CCR-1 to -5, MIP-1alp
Activation of HIV-1 long terminal repeat transcription and virus replication via NF-kappaB-dependent and -independent pathways by potent phosphotyrosine phosphatase inhibitors, the peroxovanadium compounds.: J Biol Chem. 1997 May 16;272(20):12968-77. Unique Identifier : AIDSLINE MED/97294698; Barbeau B; Bernier R; Dumais N; Briand G; Olivier M; Faure R; Posner BI; Tremblay M; Centre de Recherche en Infectiologie and Departement de; Microbiologie, Centre Hospitalier Universitaire de Quebec,; Pavillon CHUL, Faculte de Medecine, Universite Laval, Ste-Foy; (Quebec), Canada G1V 4G2.; Replication of human immunodeficiency virus type 1 (HIV-1) is increased by different cytokines and T cell activators, also known to modulate tyrosine phosphorylation levels. A novel class of protein tyrosine phosphatase (PTP) inhibitors, peroxovanadium (pV) compounds, were tested for a putative effect on HIV-1 long te
Alanine-scanning mutations in the "primer grip" of p66 HIV-1 reverse transcriptase result in selective loss of RNA priming activity.: J Biol Chem. 1997 May 16;272(20):13262-9. Unique Identifier : AIDSLINE MED/97294740; Powell MD; Ghosh M; Jacques PS; Howard KJ; Le Grice SF; Levin JG; Laboratory of Molecular Genetics, NICHD, National Institutes of; Health, Bethesda, Maryland 20892, USA.; Alanine-scanning mutants of the primer grip region of human immunodeficiency virus type 1 reverse transcriptase were tested for their ability to extend RNA and DNA versions of the polypurine tract primer, and an oligonucleotide representing the 18-nucleotide sequence at the 3 end of tRNALys3. A majority of the mutant
Gene therapy for neurologic disease: benchtop discoveries to bedside applications. 2. The bedside.: J Child Neurol. 1997 Feb;12(2):77-84. Unique Identifier : AIDSLINE MED/97229018; Maria BL; Medina CD; Hoang KB; Phillips MI; Neuro-Oncology Program, University of Florida Brain Institute and; Cancer Center, Gainesville, USA.; Important advances in basic research have made it possible to examine the safety, toxicity, and efficacy of gene therapy in humans for over 5 years. The development of sophisticated gene delivery systems has resulted in approval by the Recombinant DNA Advisory Committee (RAC) of 125 gene therapy or gene marking studie
Improved in situ hybridization to HIV with RNA probes derived from PCR products.: J Histochem Cytochem. 1997 May;45(5):721-7. Unique Identifier : AIDSLINE MED/97298743; Cone RW; Schlaepfer E; Department of Internal Medicine, University Hospital, Zurich,; Switzerland.; These experiments tested the hypothesis that a pool of PCR-derived RNA probes with defined length and even representation of the target sequences could produce more specific and intense in situ hybridization signals than randomly size-reduced, plasmid-derived RNA probes. In situ hybridization was performed with sense
Microbial products induce autoimmune disease by an IL-12-dependent pathway.: J Immunol. 1997 Jun 1;158(11):5087-90. Unique Identifier : AIDSLINE MED/97307580; Segal BM; Klinman DM; Shevach EM; Laboratory of Immunology, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892, USA.; The development and exacerbation of autoimmune diseases are associated with antecedent infectious illness. Microbial products such as LPS, bacterial DNA, or oligonucleotides containing an unmethylated cytosine-guanine dinucleotide have cytokine modulating properties. These products converted quiescent myelin basic pro
Diurnal rhythmicity of human cytokine production: a dynamic disequilibrium in T helper cell type 1/T helper cell type 2 balance?: J Immunol. 1997 Jun 1;158(11):5163-8. Unique Identifier : AIDSLINE MED/97307590; Petrovsky N; Harrison LC; Autoimmunity and Transplantation Division, The Walter and Eliza; Hall Institute of Medical Research, Royal Melbourne Hospital,; Parkville, Australia.; Diurnal rhythmicity is a characteristic of neuroendocrine pathways but is less understood in relation to immune function. We asked whether cellular (type 1) or humoral (type 2) immune responses or type 1/type 2 balance exhibit diurnal rhythmicity in healthy humans, and, if so, whether this is related to plasma levels
A selective inhibitor of dipeptidyl peptidase I impairs generation of CD8+ T cell cytotoxic effector function.: J Immunol. 1997 Jun 1;158(11):5200-10. Unique Identifier : AIDSLINE MED/97307595; Thiele DL; McGuire MJ; Lipsky PE; Department of Internal Medicine, University of Texas Southwestern; Medical Center, Dallas 75235, USA.; CTL express high levels of dipeptidyl peptidase I (DPPI), a granule thiol protease able to convert the zymogen precursors of granzymes A and B into active proteases. In the present studies, the effects of specific inhibition of DPPI on generation of CTL effector functions were examined. When T cell DPPI activity was i
Role of T lymphocyte subsets in immunity to spotted fever group Rickettsiae.: J Immunol. 1997 Jun 1;158(11):5314-20. Unique Identifier : AIDSLINE MED/97307609; Feng H; Popov VL; Yuoh G; Walker DH; University of Texas Medical Branch, Department of Pathology,; Galveston 77555, USA.; To evaluate the roles of CD4 and CD8 T lymphocytes in immunity to disseminated endothelial infection with Rickettsia conorii (Malish 7 strain), these T cell subsets were depleted or adoptively transferred into subsequently infected C3H/HeN mice. CD4 T lymphocyte-depleted and sham-depleted mice underwent a similar cour
Oral immunization with simian immunodeficiency virus p55gag and cholera toxin elicits both mucosal IgA and systemic IgG immune responses in nonhuman primates.: J Immunol. 1997 Jun 1;158(11):5321-9. Unique Identifier : AIDSLINE MED/97307610; Kubota M; Miller CJ; Imaoka K; Kawabata S; Fujihashi K; McGhee JR; Kiyono H; The Immunobiology Vaccine Center, Department of Oral Biology,; University of Alabama at Birmingham Medical Center, 35294, USA.; Rhesus macaques were orally immunized with a mucosal vaccine consisting of two different concentrations (1 mg vs 250 microg) of recombinant SIV p55gag (p55) with or without cholera toxin (CT, 50 microg) as a mucosal adjuvant. The plasma from macaques receiving t