Model compounds in elucidating the structural basis of HIV retrovirus activity. Synthesis of trisodium O-monoalkyl- and O-monoaryldiphosphates.

Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

Model compounds in elucidating the structural basis of HIV retrovirus activity. Synthesis of trisodium O-monoalkyl- and O-monoaryldiphosphates.

Boll Chim Farm. 1996 Apr;135(4):229-31. Unique Identifier : AIDSLINE MED/97070091
Gregan F; Kettmann V; Novomesky P; Misikova E; Faculty of Pharmacy, Comenius University, Bratislava, Slovakia.

Abstract: Trisodium salts of O-methyl, O-butyl, O-phenyl, and O-(4-nitrophenyl)diphosphonic acids were prepared by reaction of sodium dimethylamido-O-(2-cyanoethyl)phosphate with O-alkyl-, and O-arylphosphonic acid. In an effort to obtain anhydrous salts of the acids, besides the conventional method using aqueous sodium hydroxide, another procedure involving reaction, of sodium methoxide in methanol was also used. The structure of the final compounds was confirmed by IR, 1H NMR and 31P NMR spectra. The prepared salts of monosubstituted diphosphonic acids are used as model compounds in studying antiviral and cytostatic activity of phosphorous derivatives of purine and pyrimidine bases.

Keywords: *Anti-HIV Agents/CHEMISTRY *Diphosphates/CHEMICAL SYNTHESIS *HIV/CHEMISTRY
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