Hemophilia and nonprogressing human immunodeficiency virus type 1 infection. NLM AIDSLINE Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

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Hemophilia and nonprogressing human immunodeficiency virus type 1 infection.

Blood. 1997 Jan 1;89(1):191-200. Unique Identifier : AIDSLINE MED/97132933
Vicenzi E; Bagnarelli P; Santagostino E; Ghezzi S; Alfano M; Sinnone MS; Fabio G; Turchetto L; Moretti G; Lazzarin A; Mantovani A; Mannucci PM; Clementi M; Gringeri A; Poli G; DIBIT, Department of Infectious Diseases, San Raffaele Scientific; Institute, Milan, Italy.

Abstract: Seven of 112 hemophiliacs infected with human immunodeficiency virus type-1 (HIV-1) before 1986 through contaminated plasma products are currently healthy, with CD4 T-cell counts above 500 cells/microL, and have never received antiretroviral therapy long-term nonprogressors [LTNPs]). Seven age and sex-matched hemophiliacs infected in the same period but who have progressive HIV disease (progressors) and one additional slow-progressing individual were also studied. One hundred-fold, 20-fold, and 10-fold lower levels of full-length HIV RNA in plasma, peripheral blood mononuclear cells (PBMCs), and proviral DNA in PBMCs, respectively, were found in LTNPs compared with progressors. Plasma and cell-associated HIV RNA and proviral DNA were lower in LTNPs who tested negative for viral isolation from PBMCs or who were positive only after removal of CD8+ cells. No substantial differences were observed in the in vitro production of chemokines including RANTES, MIP-1 alpha, MIP-1 beta, MCP-1, and interleukin-8 (IL-8) in supernatants of activated PBMCs or CD8-depleted PBMCs of LTNPs, even when HIV isolation was simultaneously accomplished exclusively after removal of CD8+ cells. Low levels of HIV load and replication in peripheral blood are the strongest correlates of nonprogression in this small number of infected hemophiliacs.
Keywords: *Hemophilia/COMPLICATIONS *HIV Infections/COMPLICATIONSKWDhemophilia/complicationsKWDhivinfections/complications
970430
M9741576

Copyright © 1997 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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