[Transference factor in moderate and severe atopic dermatitis] NLM AIDSLINE Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

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[Transference factor in moderate and severe atopic dermatitis]

Rev Alerg Mex. 1996 Sep-Oct;43(5):116-23. Unique Identifier : AIDSLINE MED/97122745
Navarro Cruz D; Serrano Miranda E; Orea M; Estrada Parra S; Teran Ortiz L; Gomez Vera J; Flores Sandoval G; Servicio de alergologia e inmunologia clinica, Hospital Regional Lic,; Adolfo Lopez Mateos, ISSSTE.

Abstract: We did a prospective, comparative, experimental study with 30 patients with moderate to severe atopic dermatitis from the allergy section from September 1994 to March, 1995. The test laboratory examination was performed in all patients: complete blood cell count, immunoglobulins A, G, M and E determination, lymphocyte subpopulations CD3, CD4, CD8, CD4-CD8 proportion, CD25, rosette formation for B and T lymphocytes, coproparasitoscopic examination, throat and nose cultures, nasal cytology, skin tests of cellular immunity to PPD, thrichophytin, candidine, varidasa; skin prick test to poliens, fungi, inhalants and foods. All patients underwent to a sign and symptom grading score system as follows: the parameters were erythema, pruritus, eczema, papule valorated on a scale from 0 a 4+( O = no symptoms, = mild, ++ = moderate, + ++= severe, ++ ++ = very severe). Initially all patients received one placebo unit every 15 days orally 3 times, then one after 30 days. Laboratory examination was performed and then treatment with transfer factor was initiated, initially 1 unit every 15 days three times and the fourth 30 days after. 15 days after the last dose a new immunological valoration was done. Results demonstrate a CD4 cell decrement, blood eosinophil and lgE dissemination although they're not statistically significative. There was a statistically significative improvement in the 4 clinical parameters: erythema, eczema, pruritus and populous with the use of Transfer Factor.
Keywords: *Adjuvants, Immunologic/ADMINISTRATION & DOSAGE *Dermatitis, Atopic/IMMUNOLOGYKWDadjuvants,immunologic/administration&dosageKWDdermatitis,atopic/immunology
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Copyright © 1997 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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