Kaposi's sarcoma and non-Hodgkin's lymphoma following the diagnosis of AIDS. Multistate AIDS/Cancer Match Study Group [published erratum appears in Int J Cancer 1997 Mar 17;70(6):727]

Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

Kaposi's sarcoma and non-Hodgkin's lymphoma following the diagnosis of AIDS. Multistate AIDS/Cancer Match Study Group [published erratum appears in Int J Cancer 1997 Mar 17;70(6):727]

Int J Cancer. 1996 Dec 11;68(6):754-8. Unique Identifier : AIDSLINE MED/97134619
Biggar RJ; Rosenberg PS; Cote T; Viral Epidemiology, National Cancer Institute, Bethesda, MD, USA.; biggarb@EPNDCE.NCI.NIH.GOV

Abstract: We linked records of 83,434 AIDS cases reported to AIDS registries through 1990 to cancer registry records during times when overlap in registration existed. Of 8,496 Kaposi's-sarcoma KS) cases meeting enrollment criteria, 1,045 occurred semesters 2 through 4 (6 through 23 months) after another AIDS-defining illness. KS risk in this period after AIDS declined steadily over the 1980s. Adjusting for age, gender, ethnic origin and calendar time period, we found the relative risk (RR) of KS to be 106,000 for homo/bisexual men with AIDS and 13,000 for other men with AIDS. Risk was highest for homo/bisexual men between 30 and 39 years old and among 20- to 29-year-old non-homo/bisexual men. The RR in black men was approximately half that reported in white men among homo-bisexual men and others. Between the second and fourth semester after AIDS, the ratio of RR of KS to that of non-AIDS-related cancers increased 1.5-fold. In a similar analysis, there were 335 non-Hodgkin's lymphoma (NHL) cases in semesters 2 through 4 after AIDS. The overall risk was elevated 283-fold in homo/bisexual men and the RR ratio increased 1.8-fold between semester 2 and 4 after AIDS. In summary, the risk of KS following another AIDS-defining illness is strikingly high, more in white men than in black men, and the risks of KS and, especially, NHL appear to increase with time from AIDS.

Keywords: *Acquired Immunodeficiency Syndrome/COMPLICATIONS *Lymphoma, AIDS-Related/COMPLICATIONS *Lymphoma, Non-Hodgkin's/COMPLICATIONS *Sarcoma, Kaposi's/COMPLICATIONS
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