1997

Single stand targeted triplex formation: physicochemical and biochemical properties of foldback triplexes.: J Biomol Struct Dyn. 1996 Aug;14(1):79-90. Unique Identifier : AIDSLINE MED/97031658; Kandimalla ER; Manning A; Agrawal S; Hybridon, Inc Worcester, MA 01605, USA.; Oligodeoxyribonucleotides containing both Watson-Crick and Hoogsteen hydrogen bonding domains joined by a nucleotide loop FTFOs) are studied for their binding affinity and specificity to the DNA and RNA single-stranded targets. Thermal denaturation studies reveal that FTFOs have high binding affinity for their targets
Model compounds in elucidating the structural basis of HIV retrovirus activity. Synthesis of trisodium O-monoalkyl- and O-monoaryldiphosphates.: Boll Chim Farm. 1996 Apr;135(4):229-31. Unique Identifier : AIDSLINE MED/97070091; Gregan F; Kettmann V; Novomesky P; Misikova E; Faculty of Pharmacy, Comenius University, Bratislava, Slovakia.; Trisodium salts of O-methyl, O-butyl, O-phenyl, and O-(4-nitrophenyl)diphosphonic acids were prepared by reaction of sodium dimethylamido-O-(2-cyanoethyl)phosphate with O-alkyl-, and O-arylphosphonic acid. In an effort to obtain anhydrous salts of the acids, besides the conventional method using aqueous sodium hydroxi
Fluorometric assay for DNA polymerases and reverse transcriptase.: Biotechniques. 1996 Oct;21(4):664, 666, 668, 670, 672. Unique Identifier : AIDSLINE MED/97046297; Seville M; West AB; Cull MG; McHenry CS; Enzyco Inc., Denver, CO 80206, USA.; We report a quick, easy and inexpensive fluorometric assay that measures the activity of replication enzymes using Pico-GreenTM. The systems tested include replication of the natural template M13 Gori by E. coli DNA polymerase III holoenzyme and the replication of a synthetic homopolymer by human immunodeficiency viru
[Cerebrovascular disease as a form of presentation of HIV infection]: Neurologia. 1996 Nov;11(9):346-9. Unique Identifier : AIDSLINE MED/97139370; Palomeras E; Roquer J; Servicio de Neurologia, Hospital del Mar, Barcelona.; Several necropsy reports have suggested that cerebral vascular disease (CVD) is more frequent in HIV positive patients than in HIV negative individuals of the same age, although clinical signs are rare. We describe three patients for whom CVD was the clinical manifestation that led to diagnoses of HIV infection. The p
Inhibitors of HIV protease: unique non-peptide active site templates.: J Mol Recognit. 1996 Mar-Apr;9(2):139-42. Unique Identifier : AIDSLINE MED/97031899; Tait BD; Domagala J; Ellsworth EL; Ferguson D; Gajda C; Hupe D; Lunney EA; Tummino PJ; Department of Chemistry, Parke-Davis Pharmaceutical Research Division; of the Warner-Lambert Company, Ann Arbor, Michigan 48106, USA.; New templates were designed and prepared which straddle the active site of HIV-1 protease. These templates were designed to be flexible scaffolds upon which substituents could be appended to fill the pockets of HIV protease. The new templates prepared and analysed were 4-hydroxy-5H-furan-2-ones, 4-hydroxy-5,6-dihydr
Design and analysis of RNA structure-specific agents as potential antivirals.: J Mol Recognit. 1996 Mar-Apr;9(2):187-96. Unique Identifier : AIDSLINE MED/97031906; Wilson WD; Ratmeyer L; Zhao M; Ding D; McConnaughie AW; Kumar A; Boykin DW; Department of Chemistry, Georgia State University, Atlanta 30303, USA.; A number of pathogenic RNA viruses, such as HIV-1, have extensive folded RNA conformations with imperfect A-form duplexes that are essential for virus function, and could serve as targets for structure-specific antiviral drugs. A method for the discovery of such drugs involves evaluation of the interactions with RNA o
[Diarrhea in patients with AIDS]: Rev Esp Enferm Dig. 1996 Apr;88(4):280-6. Unique Identifier : AIDSLINE MED/97122818; Mones J; Gurgui M; Cadafalch J; Hospital de la Santa Creu i Sant Pau, Universidad Autonoma, Barcelona.
Developing a cost-effective media campaign addressing unprotected anal sex among gay men.: AIDS Educ Prev. 1996 Aug;8(4):285-93. Unique Identifier : AIDSLINE MED/97028633; Dawson C; Hartfield K; Seattle-King Country Department of Public Health AIDS Prevention; Project, WA, USA.; This paper describes the development and implementation of the Stella Seattle campaign, a media campaign targeting men who have unprotected anal sex with other men. Stella Seattle utilizes a serial cartoon strip format. Scenarios and characters in the strip are derived from local formative research on factors associat
Cognitive and emotional assessments of perceived risk for HIV among unmarried heterosexuals.: AIDS Educ Prev. 1996 Aug;8(4):294-307. Unique Identifier : AIDSLINE MED/97028634; Dolcini MM; Catania JA; Choi KH; Fullilove MT; Coates TJ; Department of Medicine, University of California, San Francisco 94105,; USA.; We examined perceived risk of contracting HIV using assessments of likelihood and worry in a probability sample of unmarried heterosexuals. Perceptions of the likelihood of contracting HIV and worry about HIV were only modestly correlated (r = .23), suggesting that they are different constructs. Far more respondents e
Self-reported risk factors for AIDS among homeless youth.: AIDS Educ Prev. 1996 Aug;8(4):308-22. Unique Identifier : AIDSLINE MED/97028635; Johnson TP; Aschkenasy JR; Herbers MR; Gillenwater SA; Survey Research Laboratory, University of Illinois at Chicago 60680,; USA.; This study assessed HIV risk behaviors in a sample of homeless youth in a large urban area and examined factors associated with these behaviors. Self-reported behaviors were assessed via interviews with 196 homeless youth in Chicago in all 10 urban shelters serving this group and in 5 street locations. Overall, 83.7%
Assessing reading level of drug users for HIV and AIDS prevention purposes.: AIDS Educ Prev. 1996 Aug;8(4):323-34. Unique Identifier : AIDSLINE MED/97028636; Johnson ME; Fisher DG; Davis DC; Cagle HH; Rhodes F; Booth R; Siegal H; Jones A; Department of Psychology, University of Alaska at Anchorage, Anchorage; 99508, USA.; Using the short form of the Woodcock Reading Mastery Test-Revised and the reading subtest of the Wide Range Achievement Test-Revised, the reading abilities of 284 male and 128 female drug users from five sites across the United States were evaluated. All subjects were participants in a
HIV-related concerns and behaviors among Hispanic women.: AIDS Educ Prev. 1996 Aug;8(4):335-42. Unique Identifier : AIDSLINE MED/97028637; Deren S; Shedlin M; Beardsley M; National Development and Research Institutes, Inc., New York, NY; 10013, USA.; Hispanic women whose sexual partners have other sexual partners may be at risk for HIV. A structured interview was administered to 106 Dominican and Puerto Rican women who reported that they knew or suspected that their partner had other partners. A subsample participated in qualitative interviews. The study assessed
Needs assessment for an urban native HIV and AIDS prevention program.: AIDS Educ Prev. 1996 Aug;8(4):343-51. Unique Identifier : AIDSLINE MED/97028638; Brassard P; Smeja C; Valverde C; Public Health Unit, Montreal General Hospital, QC, Canada.; At the request of Native community-based organizations in Montreal, a needs assessment for an HIV and AIDS education and prevention program for urban Natives was initiated. A five-session focus group concerning HIV and AIDS was attended by nine Native persons over a 2-month period. Data was collected using the guideli
Prevention implications of AIDS discourses among South African women.: AIDS Educ Prev. 1996 Aug;8(4):352-74. Unique Identifier : AIDSLINE MED/97028639; Strebel A; Department of Psychology, University of the Western Cape, Cape Town,; South Africa.; Social constructionist and feminist analyses have done much to extend the understanding of AIDS beyond the biomedical to include social accounts of the constitution of AIDS knowledge and meanings. However, these frameworks have not translated easily into realistic responses to the paradox of women being seen as respon
Assigning new meanings to traditional literature: illustrations for HIV educators.: AIDS Educ Prev. 1996 Aug;8(4):375-80. Unique Identifier : AIDSLINE MED/97028640; Leoutsakas D; Tampa AIDS Network, FL, USA.; Folk literature (folktales, fairy tales, and myths) has always had a psychological and sociological impact on humans. Parents and educators have been using stories from folk literature for generations to convey significant ideas and cultural values. With HIV being a major health concern, there is a need to establish d
Through the looking glass.: Nurs Stand. 1996 Nov 27;11(10):24-5. Unique Identifier : AIDSLINE MED/97154076; Moore O
Still alight.: Nurs Stand. 1996 Oct 30;11(6):17. Unique Identifier : AIDSLINE MED/97152115; Spence C; London Lighthouse.
AIDS research and prevention: a social representational approach.: Br J Med Psychol. 1996 Sep;69 ( Pt 3):169-90. Unique Identifier : AIDSLINE MED/97038378; Joffe H; Department of Psychology, University College London, UK.; The KABP paradigm (knowledge-attitude-belief-practice) dominates social scientific AIDS research and prevention programmes. This paper questions a number of the assumptions of the paradigm both theoretically and empirically. Having discussed a number of the paradigm s shortcomings, an alternative, a social representat
HIV and pregnancy.: Br J Obstet Gynaecol. 1996 Dec;103(12):1184-90. Unique Identifier : AIDSLINE MED/97122984; Johnstone FD; Department of Obstetrics and Gynaecology, University of Edinburgh.
A short autocomplementary sequence plays an essential role in avian sarcoma-leukosis virus RNA dimerization.: Biochemistry. 1996 Dec 24;35(51):16601-9. Unique Identifier : AIDSLINE MED/97141737; Fosse P; Motte N; Roumier A; Gabus C; Muriaux D; Darlix JL; Paoletti J; Unite de Biochimie-Enzymologie, Centre National de la Recherche; Scientifique Unite de Recherche Associee 147, Institut Gustave Roussy,; Villejuif, France.; Retroviral genomes consist of two identical RNA molecules joined noncovalently near their 5 -ends. Recently, two models have been proposed for RNA dimer formation on the basis of results obtained in vitro with human immunodeficiency virus type 1 RNA and Moloney murine leukemia virus RNA. It was first proposed that vir
A common structural motif in immunopotentiating peptides with sequences present in human autoantigens. Elicitation of a response mediated by monocytes and Th1 cells.: Biochim Biophys Acta. 1996 Dec 16;1317(3):183-91. Unique Identifier : AIDSLINE MED/97141984; Lopez-Moratalla N; Ruiz E; Lopez-Zabalza MJ; Santiago E; Department of Biochemistry, University of Navarra, Pamplona, Spain.; We have found a common structural motif in human autoantigens, heat shock proteins and viral proteins. Peptides modelled after sequences present in those molecules were synthesized and immunomodulating properties tested. They share a core of 15 amino acid residues and a common pattern ( 2-6-11 motif) characterized by
Selective endocytosis of fluorothymidine and azidothymidine coupled to LDL into HIV infected mononuclear cells.: Biochim Biophys Acta. 1996 Dec 16;1317(3):233-7. Unique Identifier : AIDSLINE MED/97141990; Mankertz J; Matthes E; Rokos K; von Baeyer H; Pauli G; Riedel E; Institut fur Biochemie, Fachbereich Chemie, Freie Universitat Berlin,; Germany.; Drug targeting via lipoproteins may be of benefit for use of cytotoxic drugs like fluorothymidine (FLT) or azidothymidine AZT ). Both drugs are potent inhibitors of the human immunodeficiency virus (HIV) reverse transcriptase and are used in the therap
Is an elevated level of serum lipoprotein (a) a risk factor for cardiovascular disease in CAPD patients?: Adv Perit Dial. 1996;12:266-71. Unique Identifier : AIDSLINE MED/97019406; Avram MM; Sreedhara R; Patel N; Chattopadhyay J; Thu T; Fein P; Division of Nephrology, Long Island College Hospital, Brooklyn, New; York, USA.; Cardiovascular disease (CVD) is the single most important cause of mortality in hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) patients. An increased lipoprotein (a) [Lp(a)] level in HD patients is associated with CVD. However, Lp(a) levels in CAPD patients are controversial, and their associat
Human immunodeficiency virus-related morbidity and mortality in injection drug users: should the AIDS definition be changed yet again? [editorial; comment]: Epidemiology. 1996 Nov;7(6):563-5. Unique Identifier : AIDSLINE MED/97055092; Royce R
Human immunodeficiency virus infection and infective endocarditis among injecting drug users [see comments]: Epidemiology. 1996 Nov;7(6):566-70. Unique Identifier : AIDSLINE MED/97055093; Manoff SB; Vlahov D; Herskowitz A; Solomon L; Munoz A; Cohn S; Willoughby SB; Nelson KE; Department of Epidemiology, Johns Hopkins University School of Hygiene; and Public Health, Baltimore, MD 21205, USA.; Human immunodeficiency virus (HIV) infection and infective endocarditis are serious complications of injection drug use. To determine whether HIV infection may increase the risk of endocarditis beyond that associated with drug injection, we performed a nested case-control study among injecting drug users taking part i
Differences in progression to AIDS between injection drug users and homosexual men with documented dates of seroconversion [see comments]: Epidemiology. 1996 Nov;7(6):571-7. Unique Identifier : AIDSLINE MED/97055094; Spijkerman IJ; Langendam MW; Veugelers PJ; van Ameijden EJ; Keet IP; Geskus RB; van den Hoek A; Coutinho RA; Municipal Health Service, Department of Public Health and Environment,; Amsterdam, The Netherlands.; We compared rates of progression to AIDS for 99 injection drug users and 120 homosexual men with documented dates of HIV-1 seroconversion. The crude risk of developing AIDS was higher among homosexual men than injection drug users [relative hazard RH) = 2.4; 95% confidence interval (CI) = 1.3-4.4]. The relative hazard
[Rhabdomyolysis and lumbosacral plexopathy in intravenous drug addict: report of a case]: An Med Interna. 1996 Feb;13(2):84-6. Unique Identifier : AIDSLINE MED/97106072; Diaz Guzman J; Pastor Valverde C; Gil Grande R; Alonso Ortiz A; Trueba Gutierrez JL; Servicio de Neurologia, Hospital Universitario Doce de Octubre,; Madrid.; There are several neuromuscular complications in the intravenous heroin addict (IHA). Someone may be due to direct toxic effect of the substance, but other ones may be associated to abuser s typical diseases (i.e. HIV infection). We present a 27 year-old IHA patient, HIV positive, that develop acute rhabdomyolisis wit
[Colony stimulating factors (G-CSF and GM-CSF): clinical update and usefulness in patients with HIV infection]: An Med Interna. 1996 Feb;13(2):87-90. Unique Identifier : AIDSLINE MED/97106073; Valencia Ortega ME; Camacho Siles J; Gonzalez Lahoz J; Servicio de Enfermedades Infecciosas, Instituto de Salud Carlos III,; Madrid.
[Pyomyositis and AIDS (letter)]: An Med Interna. 1996 Feb;13(2):97-8. Unique Identifier : AIDSLINE MED/97106079; Gregorio Vila A; Pedro-Botet Montoya ML; Sopena Galindo N; Matas Andreu L; Sabria Leal M
Treatment of Burkitt's lymphoma in HIV-positive patients.: Biomed Pharmacother. 1996;50(9):447-50. Unique Identifier : AIDSLINE MED/97145474; Straus DJ; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New; York, NY 10021, USA.; Many Burkitt s-type non-Hodgkin lymphomas (NHL) in patients without HIV infection are curable with current brief high-dose combination chemotherapy regimens. Burkitt s-type lymphomas (BL) comprise 30-40% of HIV-associated NHL. Their morphologic, clinical, cytogenetic and molecular genetic characteristics are similar t
The association of the Epstein-Barr virus with malignant lymphoma.: Biomed Pharmacother. 1996;50(9):459-67. Unique Identifier : AIDSLINE MED/97145476; Chang KL; Weiss LM; Division of Pathology, City of Hope National Medical Center, Duarte,; CA 91010-0269, USA.; The Epstein-Barr virus, a human herpesvirus, has been found in the neoplastic cells of numerous lymphoid malignancies, including Burkitt s lymphoma, immunodeficiency-associated lymphoproliferative disorders, nasal T/NK lymphoma, and Hodgkin s disease. The available data suggest that Epstein-Barr virus contributes to t
Complications and outcome of percutaneous endoscopic gastrostomy in different patient groups.: J Gastroenterol Hepatol. 1996 Sep;11(9):835-9. Unique Identifier : AIDSLINE MED/97044891; Chowdhury MA; Batey R; Department of Medicine, John Hunter Hospital, Newcastle, New South; Wales, Australia.; A retrospective study of percutaneous endoscopic gastrostomy PEG) was performed to evaluate the complications of PEG and determine the role of prophylactic antibiotics in preventing early wound infection and to evaluate the outcome of patients in different groups (neurological disease, head injury, AIDS). Percutaneous
Identification of a serpin specifically expressed in multipotent and bipotent hematopoietic progenitor cells and in activated T cells.: Blood. 1997 Jan 1;89(1):108-18. Unique Identifier : AIDSLINE MED/97132924; Hampson IN; Hampson L; Pinkoski M; Cross M; Heyworth CM; Bleackley RC; Atkinson E; Dexter TM; CRC Department of Experimental Haematology, Paterson Institute of; Cancer Research, Christie Hospital, Manchester, UK.; We have identified a gene that has a high level of mRNA expression in undifferentiated, multipotential hematopoietic cells (FDCP-Mix) and that downregulates both transcript and protein, as these cells are induced to differentiate into mature myeloid cells. Sequence analysis of this gene has identified it as a serine p
Hemophilia and nonprogressing human immunodeficiency virus type 1 infection.: Blood. 1997 Jan 1;89(1):191-200. Unique Identifier : AIDSLINE MED/97132933; Vicenzi E; Bagnarelli P; Santagostino E; Ghezzi S; Alfano M; Sinnone MS; Fabio G; Turchetto L; Moretti G; Lazzarin A; Mantovani A; Mannucci PM; Clementi M; Gringeri A; Poli G; DIBIT, Department of Infectious Diseases, San Raffaele Scientific; Institute, Milan, Italy.; Seven of 112 hemophiliacs infected with human immunodeficiency virus type-1 (HIV-1) before 1986 through contaminated plasma products are currently healthy, with CD4 T-cell counts above 500 cells/microL, and have never received antiretroviral therapy long-term nonprogressors [LTNPs]). Seven age and sex-matched hemophil
Extensive latent retroviral infection in bone marrow of patients with HTLV-I-associated neurologic disease [letter]: Blood. 1997 Jan 1;89(1):346-8. Unique Identifier : AIDSLINE MED/97132953; Levin MC; Krichavsky M; Fox RJ; Lehky T; Jacobson S; Fox C; Kleghorn F; White J; Young N; Edwards RJ; Jack NE; Bartholomew C
Effects of occupational exposure to mercury vapors on T-cell and NK-cell populations.: Arch Med Res. 1996 Winter;27(4):503-7. Unique Identifier : AIDSLINE MED/97140737; Moszczynski P; Rutowski J; Slowinski S; Bem S; Jakus-Stoga D; International Institute of Universalistic Medicine, Warsaw, Poland.; The counts of lymphocytes, (CD3+) T-cells, (CD4+) T-helper and CD 8+) T-suppressor and (CD 16+) NK-cells were determined in the peripheral blood of 81 males with a history of occupational exposure to metallic mercury vapors and in 36 males without this exposure. For the determination of T-cell populations monoclonal a
Does HIV test result influence methadone maintenance treatment retention?: J Subst Abuse. 1996;8(2):263-9. Unique Identifier : AIDSLINE MED/97035009; Wimbush J; Amicarelli A; Stein MD; Department of Medicine, Brown University, USA.; We compared groups of opioid users new to methadone maintenance to determine if persons who first learn that they are HIV-seropositive in a drug treatment program are more likely to drop out of treatment than persons who learn they are seronegative. We found no difference in patients continuation in methadone treatme
A simplified procedure for the purification of trichosanthin (a type 1 ribosome inactivating protein) from Trichosanthes kirilowii root tubers.: Protein Expr Purif. 1996 Mar;7(2):143-6. Unique Identifier : AIDSLINE MED/97005269; Bhatia N; McDonald KA; Jackman AP; Dandekar AM; Department of Chemical Engineering and Materials Science, University; of California at Davis 95616, USA.; A one step rapid and simple purification procedure for trichosanthin, a type 1 ribosome inactivating protein, from root tubers of Trichosanthes kirilowii has been developed using cation-exchange perfusion chromatography. The identity of the protein has been confirmed by its size, immunoreactivity, and sequence informa
Important statistics missing [letter]: Can Fam Physician. 1996 Dec;42:2341-2, 2344. Unique Identifier : AIDSLINE MED/97124712; DuBois MJ
Intravenous injections of the ribosome inactivating protein trichosanthin did not affect methionine enkephalin and beta-endorphin levels in the mouse brain and pituitary.: Biochem Mol Biol Int. 1996 Aug;39(5):985-9. Unique Identifier : AIDSLINE MED/97019541; Ng TB; Kwong WH; Yeung HW; Department of Biochemistry, Faculty of Medicine, Chinese University of; Hong Kong, Hong Kong.; The effect of trichosanthin on levels of the neuropeptides beta-endorphin (beta-EP) and methionine enkephalin (met-EK) in the mouse brain and pituitary was investigated. Mature male ICR mice were divided into two groups. One group received intravenous injections of physiological saline and served as the control. Anoth
The manifestation and management of staff countertransference on a pediatric AIDS team.: Bull Menninger Clin. 1996 Spring;60(2):206-18. Unique Identifier : AIDSLINE MED/97010359; Mayers AM; Svartberg M; Norwegian Center for Child Research, University of Trondheim, Norway.; The authors discuss the countertransference reactions that arise in staff who work in a hospital outpatient clinic with children with HIV and AIDS. Countertransference feelings such as guilt, anger, and helplessness can be easily aroused when working with a young, impoverished, dying population. Factors that precipita
Simultaneous determination of L-702,007, a HIV-1 reverse transcriptase inhibitor, and its 6-hydroxy metabolite in human plasma by column-switching high-performance liquid chromatography with fluorescence detection.: J Chromatogr A. 1996 Apr 5;729(1-2):211-7. Unique Identifier : AIDSLINE MED/96216792; Woolf EJ; Matuszewski B; Merck Research Laboratories, Department of Drug Metabolism, West; Point, PA 19486, USA.; A method for the determination of L-702,007, a human immunodeficiency virus type 1 reverse transcriptase inhibitor, and its 6-hydroxy metabolite in human plasma is described. Plasma samples are extracted using phenyl solid-phase extraction columns. The extract is analyzed by HPLC using a column-switching system to rem
Determination of a HIV protease inhibitor (DMP 450) in animal and human plasma by solid-phase extraction and high-performance liquid chromatography.: J Chromatogr B Biomed Appl. 1996 Apr 12;678(2):303-8. Unique Identifier : AIDSLINE MED/96346984; Grubb MF; Robinson CA; White SJ; Krauthauser CL; Shum L; Drug Metabolism and Pharmacokinetics Section, DuPont Merck; Pharmaceutical Company, Stine-Haskell Research Center, Newark, DE; 19714, USA.; Extraction of DMP 450 from plasma was performed with C2 solid-phase extraction columns, using 0.1 M ammonium acetate in 90% methanol to elute DMP 450. The extraction recovery over the range of 10 to 10 000 ng/ml averaged 81.0, 96.2, 77.4, 95.2 and 68.0% from rat, dog, monkey, chimpanzee (25-10 000 ng/ml) and human pla
The good, the bad and the ugly--can you refuse care?: Aust Nurs J. 1996 Oct;4(4):28-9. Unique Identifier : AIDSLINE MED/97082898; Napthine R
[Transference factor in moderate and severe atopic dermatitis]: Rev Alerg Mex. 1996 Sep-Oct;43(5):116-23. Unique Identifier : AIDSLINE MED/97122745; Navarro Cruz D; Serrano Miranda E; Orea M; Estrada Parra S; Teran Ortiz L; Gomez Vera J; Flores Sandoval G; Servicio de alergologia e inmunologia clinica, Hospital Regional Lic,; Adolfo Lopez Mateos, ISSSTE.; We did a prospective, comparative, experimental study with 30 patients with moderate to severe atopic dermatitis from the allergy section from September 1994 to March, 1995. The test laboratory examination was performed in all patients: complete blood cell count, immunoglobulins A, G, M and E determination, lymphocyte
Schiff base forming drugs: mechanisms of immune potentiation and therapeutic potential.: J Mol Med. 1996 Sep;74(9):497-504. Unique Identifier : AIDSLINE MED/97047134; Chen H; Rhodes J; Immunology Unit, Glaxo Wellcome Research and Development, Medicines; Research Centre, Stevenage, Hertfordshire, UK.; CD4 T-lymphocytes, which orchestrate immune responses, receive a cognitive signal when clonally distributed receptors are occupied by MHC class II bound peptides on antigen-presenting cells. The latter provide costimulatory or accessory signals through macromolecules such as B7.1 and B7.2 which interact with corecepto
Treatment of refractory diarrhoea in AIDS with acetorphan and octreotide: a randomized crossover study.: Eur J Gastroenterol Hepatol. 1996 May;8(5):485-9. Unique Identifier : AIDSLINE MED/96397994; Beaugerie L; Baumer P; Chaussade S; Berard H; Rozenbaum W; Pialoux G; Le Quintrec Y; Schwartz JC; Lecomte JM; Hopital Rothschild, Paris, France.; OBJECTIVE: To compare the efficacy and tolerance of acetorphan, an orally active enkephalinase inhibitor whose antidiarrhoeal properties derive from a purely antisecretory activity, to that of octreotide, a subcutaneously administered somatostatin analogue, in the treatment of refractory diarrhoea in AIDS patients. DE
Database of three-dimensional structures of HIV proteinases.: Nat Struct Biol. 1997 Jan;4(1):8. Unique Identifier : AIDSLINE MED/97143302; Vondrasek J; van Buskirk CP; Wlodawer A; Macromolecular Structure Laboratory, NCI-Frederick Cancer Research and; Development Center, ABL-Basic Research Program, Maryland 21702, USA.; vond@proxima.ncifcrf.gov
[Mechanisms of reduction of CD4 receptor expression on the surface of HIV-1 infected cells]: C R Acad Sci III. 1996 Aug;319(8):653-62. Unique Identifier : AIDSLINE MED/97106640; Geleziunas R; Morin N; Wainberg MA; Centre SIDA de l'Universite McGill, Montreal, Quebec, Canada.; Specific interactions between the cell surface CD4 receptor and the HIV-1 envelope glycoprotein gp120 are responsible for the entry of HIV into host cells. Following infection, a down-modulation of CD4 at the cell surface is commonly observed. This may render cells resistant to subsequent infection by HIV as well as o
Clinical characteristics and management responses in 85 HIV-infected patients with oral candidiasis.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996 Oct;82(4):402-7. Unique Identifier : AIDSLINE MED/97055490; Silverman S Jr; Gallo JW; McKnight ML; Mayer P; deSanz S; Tan MM; Division of Oral Medicine, School of Dentistry, University of; California, San Francisco, USA.; Eighty-five consecutively seen HIV-positive persons with oral candidiasis were evaluated for clinical characteristics, staging of HIV disease, quantitation of candidal colony formation, and response to systemic antifungal treatment with Nizoral ketoconazole). Fifty-five had CD4 counts less than 200. There was an incon
Oral hairy leukoplakia in a patient with multiple myeloma.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996 Oct;82(4):408-10. Unique Identifier : AIDSLINE MED/97055491; Blomgren J; Back H; Clinic of Oral Medicine, Ostra University Hospital, Goteborg, Sweden.; The first case of oral hairy leukoplakia in an HIV-negative patient with multiple myeloma is reported. The patient is a 56-year old man who has had monoclonal gammopathy of undetermined significance since 1986 and has been treated for a symptomatic multiple myeloma since 1993. The clinical and histopathologic findings
Alcohol consumption, brothel attendance, and condom use: normative expectations among Thai military conscripts.: Med Anthropol Q. 1996 Sep;10(3):402-23. Unique Identifier : AIDSLINE MED/97026848; MacQueen KM; Nopkesorn T; Sweat MD; Sawaengdee Y; Mastro TD; Weniger BG; Somdej Pranaresuan Maharaj Hospital, Phitsanuloke, Thailand.; This article investigates the relationship between alcohol consumption and inconsistent condom use with brothel-based commercial sex workers among Thai military conscripts in Northern Thailand . Data from 10 focus groups indicate that alcohol consumption (1) is consciously used by
[The tasks of public health organs concerning the prevention of infectious diseases]: Lik Sprava. 1996 Jan-Feb;(1-2):166-72. Unique Identifier : AIDSLINE MED/97085130; Mariievs'kyi VF
AIDS and Leishmania infantum. New approaches for a new epidemiological problem.: Clin Dermatol. 1996 Sep-Oct;14(5):541-6. Unique Identifier : AIDSLINE MED/97044262; Alvar J; Gutierrez-Solar B; Pachon I; Calbacho E; Ramirez M; Valles R; Guillen JL; Canavate C; Amela C; Reference Laboratory of Leishmaniasis, Centro Nacional de; Microbiologia, Instituto de Salud Carlos III, Madrid, Spain.
Overexpression of DNA polymerase beta sensitizes mammalian cells to 2',3'-deoxycytidine and 3'-azido-3'-deoxythymidine.: Cancer Res. 1997 Jan 1;57(1):110-6. Unique Identifier : AIDSLINE MED/97141792; Bouayadi K; Hoffmann JS; Fons P; Tiraby M; Reynes JP; Cazaux C; Laboratoire de Microbiologie et de Genetique, Universite Paul; Sabatier, Toulouse, France.; Mammalian DNA polymerase beta is a DNA repair enzyme expressed constitutively at a low level. In vitro, purified DNA polymerase Pol) beta incorporates the nucleotide analogues 2 -3 deoxycytidine ( ddC )-triphosphate and 3 -azido-3 -deoxythymidine
Identification of naturally processed human ovarian peptides recognized by tumor-associated CD8+ cytotoxic T lymphocytes.: Cancer Res. 1997 Jan 1;57(1):87-93. Unique Identifier : AIDSLINE MED/97141788; Fisk B; Anderson BW; Gravitt KR; O'Brian CA; Kudelka AP; Murray JL; Wharton JT; Ioannides CG; Department of Gynecologic Oncology, M. D. Anderson Cancer Center,; Houston, Texas 77030, USA.; Identification of naturally processed peptides recognized by tumorspecific CTLs may lead to epitope-specific tumor vaccines. Because these epitopes may be expressed differently on epithelial tumors and may differ in their ability to induce CTL in vivo, we have isolated the HLA-A2-peptide complexes by immunoaffinity fr
Sequential use of neural networks for survival prediction in AIDS.: Proc AMIA Annu Fall Symp. 1996;:170-4. Unique Identifier : AIDSLINE MED/97103278; Ohno-Machado L; Decision Systems Group, Brigham and Women's Hospital, Harvard Medical; School, Boston, MA 02115, USA. machado@dsg.harvard.edu; Prognostic assessment of patients is a key part of medical care. Although neural networks can be used to model survival, their accuracy has been limited for a variety of factors, including (1) the lack of data balance in certain intervals and (2) the lack of representation of temporal dependencies in the network archi
Trimethoprim-sulfamethoxazole: hyperkalemia is an important complication regardless of dose.: Clin Nephrol. 1996 Sep;46(3):187-92. Unique Identifier : AIDSLINE MED/97034198; Perazella MA; Mahnensmith RL; Department of Medicine, Yale University School of Medicine, New Haven,; CT 06520-8029, USA.; Trimethoprim-sulfamethoxazole is a frequently prescribed antibiotic with a wide spectrum of antimicrobial activity. As a result of the increasing number of AIDS patients requiring therapy for Pneumocystis carinii pneumonia, high dose trimethoprim-sulfamethoxazole use had dramatically increased. A previously unreported
Trimethoprim-sulfamethoxazole and hypouricemia.: Clin Nephrol. 1996 Sep;46(3):193-8. Unique Identifier : AIDSLINE MED/97034199; Chertow GM; Seifter JL; Christiansen CL; O'Donnell WJ; Renal Division, Brigham and Women's Hospital, Boston, MA 02115, USA.; BACKGROUND: Hypouricemia has been reported in a substantial fraction of patients with AIDS and attributed to an HIV-related renal urate transport defect. We tested the alternative hypothesis that hypouricemia was associated with the administration of high-dose trimethoprim-sulfamethoxazole TMP-SMX). METHODS: Sociodemo
Adrenal insufficiency, recurrent bacteremia, and disseminated abscesses caused by Nocardia asteroides in a patient with acquired immunodeficiency syndrome.: Diagn Microbiol Infect Dis. 1996 Jan;24(1):47-51. Unique Identifier : AIDSLINE MED/97142742; Arabi Y; Fairfax MR; Szuba MJ; Crane L; Schuman P; Department of Medicine, Wayne State University School of Medicine,; Detroit, Michigan, USA.; Nocardia asteroides is an opportunistic pathogen of increasing incidence in human immunodeficiency virus (HIV)-infected persons. The lungs are the most common site of infection, followed by the brain; involvement of other extrapulmonary sites is less common. We describe a patient with acquired immunodeficiency syndrom
Presumed bilateral herpes zoster ophthalmicus in an AIDS patient: a case report.: Cornea. 1996 Nov;15(6):633-4. Unique Identifier : AIDSLINE MED/97054988; Yau TH; Butrus SI; Department of Ophthalmology, Washington Hospital Center, DC, USA.; A 31-year-old man with the acquired immunodeficiency syndrome presented with herpes zoster ophthalmicus on the right. Five days after he began treatment for the zoster pseudodendrites and skin lesions, he developed superficial punctate keratitis, uveitis, and crusting skin lesions in the left eye. After treatment, the
Hepatic and pulmonary biopsy by mini-thoracotomy and transdiaphragmatic access.: Chest. 1996 Dec;110(6):1384-6. Unique Identifier : AIDSLINE MED/97143038; Fernandez A; Vip DE; Strabelli TM; Bammann RH; Vargas FS; Jatene FB; Division of Thoracic Surgery, Hospital das Clinicas University of Sao; Paulo Medical School, Brazil.; Frequently, immunodeficient patients have more than one organ or system affected by opportunistic infection or neoplasia, requiring quick and precise diagnostic investigation. In some situations, different invasive diagnostic procedures may be necessary. Open lung biopsy is sometimes necessary to clarify the pulmonary
Fluconazole vs itraconazole-flucytosine association in the treatment of esophageal candidiasis in AIDS patients. A double-blind, multicenter placebo-controlled study. The Candida Esophagitis Multicenter Italian Study (CEMIS) Group.: Chest. 1996 Dec;110(6):1507-14. Unique Identifier : AIDSLINE MED/97143058; Barbaro G; Barbarini G; Di Lorenzo G; Department of Emergency Medicine, University La Sapienza, Rome, Italy.; STUDY OBJECTIVE: To assess the role and the therapeutic efficacy of fluconazole and itraconazole-flucytosine association compared with placebo, in the treatment of endoscopically diagnosed esophageal candidiasis in a selected population of AIDS patients. DESIGN: Double-blind, placebo-controlled study. SETTING: Univers
Oxidant-protease interaction in the lung. Prospects for antioxidant therapy.: Chest. 1996 Dec;110(6 Suppl):267S-272S. Unique Identifier : AIDSLINE MED/97143152; Buhl R; Meyer A; Vogelmeier C; Medizinische Klinik II, Zentrum der Inneren Medizin,; Johann-Wolfgang-Goethe-Universitat, Frankfurt, Germany.; In inflammatory lung disorders, oxidants and proteases complement each other in their potential to destroy lung parenchyma. It is therefore rational to combine therapeutic strategies aimed at augmenting the antiproteolytic defenses of the lung in diseases such as emphysema with antioxidant strategies. In the healthy l
Comparison of itraconazole and ketoconazole in HIV-positive patients with oropharyngeal or esophageal candidiasis.Human Immunodeficiency Virus Itraconazole Ketoconazole Project Group.: Chemotherapy. 1996 Sep-Oct;42(5):374-83. Unique Identifier : AIDSLINE MED/97028965; de Repentigny L; Ratelle J; Department of Microbiology and Immunology, Faculty of Medicine,; University of Montreal, Que., Canada.; The efficacy of oral itraconazole and ketoconazole in the treatment of oropharyngeal and/or esophageal candidiasis, and the rate of post-treatment relapse, were compared in a multicenter, prospective, double-blind, double-dummy, randomized, parallel-group trial. A total of 143 adult HIV-positive patients with orophary
How many gated lymphocytes are needed for accurate assessment of T-subset percentages by flow cytometry?: Cytometry. 1996 Sep 15;26(3):223-6. Unique Identifier : AIDSLINE MED/97044324; Lape'-Nixon ML; Prince HE; MRL Reference Laboratory, Cypress, California 90630, USA.; Current regulatory agencies specify the use of 2,500 gated lymphocytes for accurate lymphocyte immunophenotyping by flow cytometry. However, acquisition of 2,500 gated lymphocytes is often technically infeasible when testing whole blood from lymphopenic patients. Our laboratory thus compared CD3, CD4, and CD8 percenta
Reference intervals of CD3, CD4, CD8, CD4/CD8, and absolute CD4 values in Asian and Non-Asian populations.: Cytometry. 1996 Sep 15;26(3):231-2. Unique Identifier : AIDSLINE MED/97044326; Howard RR; Fasano CS; Frey L; Miller CH; Department of Pathology, University of California Medical Center,; Davis at Sacramento, USA.; A study to determine reference intervals in normal Asian and non-Asian populations for CD3 (T cells), CD4 (T helper/inducer cells), CD8 (T suppressor/cytotoxic cells), and for the CD4/CD8 ratio and absolute CD4 lymphocyte count was performed. Coulter Clone/Cytostat reagents were used. The samples were lysed using the
Ritonavir.: Drugs. 1996 Oct;52(4):541-6; discussion 547-8. Unique Identifier : AIDSLINE MED/97046545; Lea AP; Faulds D; Adis International Limited, Auckland, New Zealand.; Ritonavir is a protease inhibitor with an HIV-1 resistance profile similar to that of indinavir , but different from that of saquinavir. Ritonavir has good oral bioavailability, and ma
Endoscopic diagnosis of a duodenocolic fistula due to a non-Hodgkin's lymphoma in a patient with AIDS.: Endoscopy. 1996 Aug;28(6):528-9. Unique Identifier : AIDSLINE MED/97041378; Becheur H; Piketty C; Bloch F; Levoir D; Aubertin JM; Bouillot JL; Petite JP; Dept. of Hepatogastroenterology, Broussais Hospital, Paris, France.
Biosynthesis and N-glycosylation of human interferon-gamma. Asn25 and Asn97 differ markedly in how efficiently they are glycosylated and in their oligosaccharide composition.: Eur J Biochem. 1996 Dec 1;242(2):191-200. Unique Identifier : AIDSLINE MED/97129092; Sareneva T; Mortz E; Tolo H; Roepstorff P; Julkunen I; Department of Virology, National Public Health Institute, Helsinki,; Finland.; Interferon-gamma (IFN-gamma) is a secretory glycoprotein produced by T cells in response to antigenic or mitogenic stimuli. We studied the kinetics of the synthesis, N-glycosylation, and secretion of IFN-gamma in human CD8+ T lymphocytes stimulated via T-cell receptor. Highly elevated IFN-gamma mRNA levels were found
Predictive value of HIV-1 RNA detection in plasma by branched DNA assay during long-term zidovudine therapy.: Eur J Clin Microbiol Infect Dis. 1996 Aug;15(8):639-45. Unique Identifier : AIDSLINE MED/97049843; Cotte L; Trabaud MA; Rougier P; Bailly F; Chapuis F; Trepo C; Service d'Hepatogastroenterologie et de SIDA, Hotel-Dieu, Lyon,; France.; The predictive value of human immunodeficiency virus type 1 HIV-1) RNA detection in plasma using branched DNA assay was studied in a subgroup of 36 asymptomatic HIV-1-infected patients enrolled in a multicenter, double-blind, randomized study. Patients were randomized to receive either zidovudine (
Acute myocarditis mimicking myocardial infarction in an HIV infected patient [letter]: Eur Heart J. 1996 Sep;17(9):1449. Unique Identifier : AIDSLINE MED/97034378; Monsuez JJ; Ferchal F; Evans J; Lachurie ML; Passeron J
Vertical human immunodeficiency virus-1 infection: involvement of the central nervous system and treatment.: Eur J Pediatr. 1996 Oct;155(10):839-50. Unique Identifier : AIDSLINE MED/97046631; Exhenry C; Nadal D; Infectious Diseases Unit, University Children's Hospital of Zurich,; Switzerland.; Involvement of the central nervous system (CNS) contributes substantially to morbidity and mortality of vertical infection with the human immunodeficiency virus (HIV)-1. The clinical spectrum ranges from minor developmental disabilities to severe and progressive encephalopathy. Progression of the disease varies consid
Identification and isolation of a 155-kDa protein with neuropathy target esterase activity.: Fundam Appl Toxicol. 1996 Mar;30(1):23-30. Unique Identifier : AIDSLINE MED/96436320; Mackay CE; Hammock BD; Wilson BW; Department of Avian Science and Environmental Toxicology, University; of California, Davis 95616, USA.; A method is presented for the isolation of a 155-kDa protein that possesses phenyl valerate hydrolysis activity in the presence of paraoxon but is inhibited by mipafox; the functional definition of neuropathy target esterase (neurotoxic esterase; NTE). Microsomes, isolated from 18-day-old chicken embryos were treated
Endoscopic appearance of Mycobacterium genavense: case report and review of the literature [see comments]: Gastrointest Endosc. 1996 Sep;44(3):331-3. Unique Identifier : AIDSLINE MED/97039810; Koehler M; Chak A; Setrakian S; Sivak MV Jr; Division of Gastroenterology, Case Western Reserve University,; University Hospitals of Cleveland, OH 44106, USA.
Biliary fistula in a patient with HIV cholangiopathy.: Gastrointest Endosc. 1996 Sep;44(3):345-8. Unique Identifier : AIDSLINE MED/97039815; Cacciarelli AG; Freiman HJ; Anderson JD; Robilotti JG; St. Vincent's Hospital and Medical Center, Department of Medicine, New; York, NY 10011, USA.
Activation of the HIV long terminal repeat and viral production by H2O2-vanadate.: Free Radic Biol Med. 1996;20(6):813-20. Unique Identifier : AIDSLINE MED/96285844; Kazazi F; Koehler JK; Klebanoff SJ; Department of Medicine, University of Washington School of Medicine,; Seattle, USA.; The long terminal repeat (LTR) of human immunodeficiency virus type 1 (HIV-1) contains sequences required for the initiation of gene transcription. Among the substances known to activate the HIV-1 LTR is hydrogen peroxide (H2O2). We report here that H2O2-induced activation of the LTR in the macrophage cell line THP-1
[Tracking down natural resistance to HIV. Defective cellular receptor prevents entrance of virus into the cell]: Fortschr Med. 1996 Oct 20;114(29):12, 14. Unique Identifier : AIDSLINE MED/97087760; Hobom B
A case of hepatocellular carcinoma in HIV-infected patient.: Hepatogastroenterology. 1996 Jul-Aug;43(10):1067-72. Unique Identifier : AIDSLINE MED/97038760; Tanaka T; Imamura A; Masuda G; Ajisawa A; Negishi M; Tanaka S; Koike M; Hattori N; Liver Unit, Tokyo Metropolitan Komagome Hospital, Japan.; Persistent human immunodeficiency virus (HIV) infection induces an immuno-suppressive state and therefore malignant tumors are a very common complication. Hepatocellular carcinoma is very rare, however, because it is associated with chronic liver disease by the persistent infection of hepatitis B or C virus (HBV or HC
Cytomegalovirus enteritis causing massive bleeding in a patient with AIDS.: Hepatogastroenterology. 1996 Jul-Aug;43(10):987-91. Unique Identifier : AIDSLINE MED/97038744; Lai IR; Chen KM; Shun CT; Chen MY; Department of Surgery, National Taiwan University Hospital, Taipei.; An emergency operation was performed on a 58 year-old heterosexual male patient for massive lower gastrointestinal bleeding, which was caused by cytomegalovirus ( CMV ) related ulceration at the terminal ileum. Pre-operative en
Lamivudine is effective in suppressing hepatitis B virus DNA in Chinese hepatitis B surface antigen carriers: a placebo-controlled trial.: Hepatology. 1997 Jan;25(1):241-4. Unique Identifier : AIDSLINE MED/97138272; Lai CL; Ching CK; Tung AK; Li E; Young J; Hill A; Wong BC; Dent J; Wu PC; Department of Medicine, University of Hong Kong.; Lamivudine is a novel 2 ,3 -dideoxy cytosine analogue that has potent inhibitory effects on hepatitis B virus replication in vitro and in vivo. We performed a single-blind, placebo-controlled study to assess its effectiveness and safety in Chinese hep
Immune deviation--the third dimension of nondeletional T cell tolerance.: Immunol Rev. 1996 Feb;149:175-94. Unique Identifier : AIDSLINE MED/96402166; Rocken M; Shevach EM; Department of Dermatology, Ludwig-Maximilians-University Munchen,; Germany.
Mechanisms of peripheral tolerance and suppression induced by monoclonal antibodies to CD4 and CD8.: Immunol Rev. 1996 Feb;149:5-33. Unique Identifier : AIDSLINE MED/96402159; Cobbold SP; Adams E; Marshall SE; Davies JD; Waldmann H; Therapeutic Immunology Group, Sir William Dunn School of Pathology,; Oxford, UK.; Over the last five years it has become increasingly clear that the peripheral immune system can maintain tolerance to both self and non-self antigens through a variety of mechanisms. Although clonal deletion may play an important part in limiting rapidly expanding responses, there are many examples where antigen react
Similar abnormalities of idiotype and immunoglobulin light chain expression and of cell-mediated cytotoxicity in HIV-infected humans and simian immunodeficiency virus (SIV)-infected rhesus macaques.: Immunol Cell Biol. 1996 Feb;74(1):38-44. Unique Identifier : AIDSLINE MED/97088744; Grant MD; Whaley MD; Mayne A; Hoffmann GW; Ansari AA; Department of Microbiology and Immunology, University of British; Columbia, Vancouver, Canada.; The pathogenesis of AIDS in simian immunodeficiency virus SIV)-infected rhesus macaques models the pathogenesis of human AIDS. We investigated whether certain immunological abnormalities associated with HIV infection and implicated in disease progression also occur in SIV infection. We observed striking parallels betw
Kaposi's sarcoma and non-Hodgkin's lymphoma following the diagnosis of AIDS. Multistate AIDS/Cancer Match Study Group [published erratum appears in Int J Cancer 1997 Mar 17;70(6):727]: Int J Cancer. 1996 Dec 11;68(6):754-8. Unique Identifier : AIDSLINE MED/97134619; Biggar RJ; Rosenberg PS; Cote T; Viral Epidemiology, National Cancer Institute, Bethesda, MD, USA.; biggarb@EPNDCE.NCI.NIH.GOV; We linked records of 83,434 AIDS cases reported to AIDS registries through 1990 to cancer registry records during times when overlap in registration existed. Of 8,496 Kaposi s-sarcoma KS) cases meeting enrollment criteria, 1,045 occurred semesters 2 through 4 (6 through 23 months) after another AIDS-defining illness.
Microsatellite instability in B-cell lymphoma originating from Bloom syndrome.: Int J Cancer. 1996 Dec 20;69(6):480-3. Unique Identifier : AIDSLINE MED/97134691; Kaneko H; Inoue R; Yamada Y; Sukegawa K; Fukao T; Tashita H; Teramoto T; Kasahara K; Takami T; Kondo N; Department of Pediatrics, Gifu University School of Medicine,; Tsukasa-mati, Japan. hideo@cc.gifu-u.ac.jp; Bloom syndrome (BS) is a rare autosomal recessive genetic disorder characterized by lupus-like erythematous telangiectasias of the face, sun sensitivity, stunted growth infertility and immunodeficiency. In addition, BS patients are highly predisposed to cancers. Although recently the causative gene of BS (BLM) was ide
Dendritic epidermal T-cell involvement in induction of CD8+ T cell-mediated immunity against an ultraviolet radiation-induced skin tumor.: Int J Cancer. 1997 Jan 6;70(1):98-105. Unique Identifier : AIDSLINE MED/97138071; Cavanagh LL; Barnetson RS; Basten A; Halliday GM; Department of Medicine (Dermatology), University of Sydney at Royal; Prince Alfred Hospital, Camperdown, Australia. loisc@gpo.pa.uq.edu.au; Murine epidermis contains 2 distinct cell populations which contribute to the skin immune system, Langerhans cells (LC), and dendritic epidermal T cells (DETC). LCs are important in the induction of immunity against a wide range of antigens; however, the function of DETC is unclear. To investigate the roles of these e
Sequential cellular and humoral responses in the abomasal mucosa and blood of Romney sheep dosed with Trichostrongylus axei.: Int J Parasitol. 1996 Jul;26(7):765-73. Unique Identifier : AIDSLINE MED/97050040; Pfeffer A; Douch PG; Shaw RJ; Gatehouse TK; Rabel B; Green RS; Shirer CL; Jonas WE; Bisset S; Wallaceville Animal Research Centre, AgResearch, Upper Hutt, New; Zealand. Pfeffera@agresearch.cri.nz; Abomasal cannulae were surgically placed in 7 2-year-old New Zealand Romney sheep which had been maintained parasite-free from birth. Four of these sheep were randomly selected and dosed orally with 10,000 infective Trichostrongylus axei larvae per week for 8 weeks, while the r
Growth of Lucilia cuprina larvae following treatment of sheep divergently selected for fleece rot and fly strike with monoclonal antibodies to T lymphocyte subsets and interferon gamma.: Int J Parasitol. 1996 Jul;26(7):775-82. Unique Identifier : AIDSLINE MED/97050041; Colditz IG; Eisemann CH; Tellam RL; McClure SJ; Mortimer SI; Husband AJ; CSIRO Division of Animal Production, Pastoral Research Laboratory,; Armidale, NSW 2350, Australia. icolditz@chiswick.anprod.csiro.au; Intensive lymphocytic infiltration of the underlying dermis occurs during cutaneous myiasis caused by larvae of the blow fly, Lucilia cuprina. To determine the effect of this infiltrate on larval growth, monoclonal antibodies (mAb) to CD4, CD8 or WC1 lymphocyte subset determinants were injected intravenously before an
Nursing: sustaining the circle of life in HIV/AIDS prevention and care [news]: Int Nurs Rev. 1996 Sep-Oct;43(5):132. Unique Identifier : AIDSLINE MED/97050109
Natasha's story: seeking an FIV diagnosis [news]: J Am Vet Med Assoc. 1996 Nov 15;209(10):1680. Unique Identifier : AIDSLINE MED/97079282; Kahler SC
FIV diagnosis not an imminent death sentence [news]: J Am Vet Med Assoc. 1996 Dec 1;209(11):1832. Unique Identifier : AIDSLINE MED/97100229; Kahler SC
Human immunodeficiency virus. Mutations in the viral protease that confer resistance to saquinavir increase the dissociation rate constant of the protease-saquinavir complex.: J Biol Chem. 1996 Dec 27;271(52):33231-5. Unique Identifier : AIDSLINE MED/97125958; Maschera B; Darby G; Palu G; Wright LL; Tisdale M; Myers R; Blair ED; Furfine ES; Department of Virology, Glaxo Wellcome, Stevenage SG1 2NY, United; Kingdom.; Mutations in the human immunodeficiency virus (HIV) protease L90M, G48V, and L90M/G48V) arise when HIV is passaged in the presence of the HIV protease inhibitor saquinavir. These mutations yield a virus with less sensitivity to the drug (L90M > G48V >> L90M/G48V). L90M, G48V, and L90M/G48V proteases have 1/20, 1/160,
Restoration of both structure and function to a defective poly(A) site by in vitro selection.: J Biol Chem. 1996 Dec 27;271(52):33654-63. Unique Identifier : AIDSLINE MED/97126013; Graveley BR; Fleming ES; Gilmartin GM; Department of Microbiology and Molecular Genetics, Markey Center for; Molecular Genetics, Stafford Hall, University of Vermont, Burlington,; Vermont 05405, USA. ggilmart@moose.uvm.edu; Efficient cleavage and polyadenylation at the human immunodeficiency virus type-1 (HIV-1) poly(A) site requires an upstream 3 -processing enhancer to overcome the suboptimal sequence context of the AAUAAA hexamer. The HIV-1 3 -processing enhancer functions to stabilize the association of the pre-mRNA with cleavage and
NCp7 activates HIV-1Lai RNA dimerization by converting a transient loop-loop complex into a stable dimer.: J Biol Chem. 1996 Dec 27;271(52):33686-92. Unique Identifier : AIDSLINE MED/97126017; Muriaux D; De Rocquigny H; Roques BP; Paoletti J; Unite de Biochimie, URA 147 CNRS, 39 rue Camille Desmoulins, Institut; Gustave Roussy, 94805 Villejuif, France.; Nucleocapsid protein 7 (NCp7), the human immunodeficiency virus type 1 (HIV-1) nucleocapsid protein, was shown to strongly potentiate the dimerization of the retroviral genomic RNA. This process involves the interaction of two retroviral RNA monomer subunits near their 5 -ends. A region located upstream from the splic
Leiomyoma of the hand in a child who has the human immunodeficiency virus.: J Bone Joint Surg Am. 1996 Dec;78(12):1904-6. Unique Identifier : AIDSLINE MED/97140178; Yang SS; Williams RJ; Bear BJ; McCormack RR; The New York Hospital-Cornell Medical Center, New York City, N.Y.,; USA.
Human T-cell lymphotropic virus type-I associated myelopathy complicated by optic neuritis.: Nippon Ika Daigaku Zasshi. 1996 Oct;63(5):414-8. Unique Identifier : AIDSLINE MED/97091415; Komaba Y; Kitamura S; Terashi A; Tamotsu M; Nakatani Y; Hara A; Second Department of Internal Medicine, Nippon Medical School, Tokyo,; Japan.; A 48-year-old Japanese woman from Kyushu was admitted to the Nippon Medical School First Hospital with complaints of numbness in both legs, gait disturbance, and urinary problems. On examination, her lower extremities were spastic with increased reflexes and positive Babinski sign. Sensation was absent below the T4 sp
Evaluation of an extended blood culture protocol to isolate fastidious organisms from patients with AIDS.: J Clin Microbiol. 1996 Oct;34(10):2444-7. Unique Identifier : AIDSLINE MED/97034841; Dougherty MJ; Spach DH; Larson AM; Hooton TM; Coyle MB; Department of Laboratory Medicine, Harborview Medical Center,; University of Washington, Seattle 98104, USA.; Recent reports of fastidious pathogens suggest the need for special blood cultures for immunocompromised patients. Blood cultures from 45 human immunodeficiency virus (HIV)-infected patients with unexplained fever (> or = 38.0 degrees C) and CD4 counts of
Diagnostic antigenemia tests for penicilliosis marneffei.: J Clin Microbiol. 1996 Oct;34(10):2503-5. Unique Identifier : AIDSLINE MED/97034853; Kaufman L; Standard PG; Jalbert M; Kantipong P; Limpakarnjanarat K; Mastro TD; Division of Bacterial and Mycotic Diseases, National Center for; Infectious Diseases, Centers for Disease Control and Prevention,; Atlanta, Georgia 30333, USA.; Disseminated penicilliosis marneffei is an emerging opportunistic mycosis seen in severely immunocompromised human immunodeficiency virus (HIV)-infected patients and is caused by the dimorphic fungus Penicillium marneffei. Early diagnosis and treatment improve clinical outcome. Proper diagnosis is complicated by nonsp
Prevalence of human herpesvirus 8 DNA sequences in several patient populations.: J Clin Microbiol. 1996 Oct;34(10):2635-8. Unique Identifier : AIDSLINE MED/97034886; Marchioli CC; Love JL; Abbott LZ; Huang YQ; Remick SC; Surtento-Reodica N; Hutchison RE; Mildvan D; Friedman-Kien AE; Poiesz BJ; Department of Internal Medicine, SUNY Health Science Center, Syracuse; 13210, USA.; We have undertaken a large-scale study of various tissues from normal controls and patients with Kaposi s sarcoma (KS) or other malignancies, both with and without human immunodeficiency virus infection, to determine the prevalence of human herpesvirus 8 HHV-8) DNA. A total of 566 specimens were analyzed by PCR for th
Accelerated neutrophil apoptosis in the acquired immunodeficiency syndrome.: J Clin Invest. 1996 Dec 15;98(12):2714-9. Unique Identifier : AIDSLINE MED/97136515; Pitrak DL; Tsai HC; Mullane KM; Sutton SH; Stevens P; Department of Medicine, University of Illinois College of Medicine at; Chicago, West Side VA Medical Center, 60612, USA.; Neutrophil (PMNL) function defects occur as a consequence of HIV infection. This study examined PMNL apoptosis in patients with the acquired immunodeficiency syndrome (AIDS) to determine if accelerated apoptosis contributes to impaired function. PMNL were isolated from 10 HIV-infected patients with CD4+ lymphocyte cou
HLA-B27 heavy chains contribute to spontaneous inflammatory disease in B27/human beta2-microglobulin (beta2m) double transgenic mice with disrupted mouse beta2m.: J Clin Invest. 1996 Dec 15;98(12):2746-55. Unique Identifier : AIDSLINE MED/97136519; Khare SD; Hansen J; Luthra HS; David CS; Department of Immunology, Mayo Clinic and Medical School, Rochester,; Minnesota 55905, USA.; MHC class I allele, HLA-B27, is strongly associated with a group of human diseases called spondyloarthropathies. Some of these diseases have an onset after an enteric or genitourinary infection. In the present study, we describe spontaneous disease in HLA-B27 transgenic mice where endogenous beta2-microglobulin beta2m
Long-lived and transferable tumor immunity in mice after targeted interleukin-2 therapy.: J Clin Invest. 1996 Dec 15;98(12):2801-4. Unique Identifier : AIDSLINE MED/97136526; Becker JC; Varki N; Gillies SD; Furukawa K; Reisfeld RA; The Scripps Research Institute, Department of Immunology, La Jolla,; California 92037, USA.; A major goal of tumor immunotherapy is the induction of tumor-specific T cell responses that are effective in eradicating disseminated tumor, as well as mounting a persistent tumor-protective immunity. We demonstrate here that a genetically engineered fusion protein consisting of human/mouse chimeric anti-ganglioside
Iron deficiency, giardiasis and HIV disease [editorial; comment]: J Am Coll Nutr. 1996 Oct;15(5):421. Unique Identifier : AIDSLINE MED/97047246; Filer LJ Jr
Down-regulation of IL-12, not a shift from a T helper-1 to a T helper-2 phenotype, is responsible for impaired IFN-gamma production in mammary tumor-bearing mice.: J Immunol. 1997 Jan 1;158(1):280-6. Unique Identifier : AIDSLINE MED/97131699; Handel-Fernandez ME; Cheng X; Herbert LM; Lopez DM; Department of Microbiology and Immunology, University of Miami School; of Medicine, FL 33101, USA.; Altered cytokine production has been implicated in the down-regulation of cell-mediated immunity in mice bearing large mammary tumors. In several diseases, an imbalance between helper T lymphocytes Th1 and Th2 and their cytokines has been suggested as a contributing factor. In this study, although IFN-gamma from splen
Immune CD8+ T lymphocytes lyse Listeria monocytogenes-infected hepatocytes by a classical MHC class I-restricted mechanism.: J Immunol. 1997 Jan 1;158(1):287-93. Unique Identifier : AIDSLINE MED/97131700; Jiang X; Gregory SH; Wing EJ; Department of Medicine, University of Pittsburgh Medical Center, PA; 15213, USA.; Hepatocytes constitute the principal site of listerial replication in the livers of mice infected i.v. CD8+ T lymphocytes play a predominant role in the host defenses to Listeria monocytogenes. In vitro experiments by others undertaken to delineate the functions of CD8+ T lymphocytes have focused primarily on their in
Blockade of CD40 ligand-CD40 interaction impairs CD4+ T cell-mediated alloreactivity by inhibiting mature donor T cell expansion and function after bone marrow transplantation.: J Immunol. 1997 Jan 1;158(1):29-39. Unique Identifier : AIDSLINE MED/97131671; Blazar BR; Taylor PA; Panoskaltsis-Mortari A; Buhlman J; Xu J; Flavell RA; Korngold R; Noelle R; Vallera DA; Department of Pediatrics, University of Minnesota, Minneapolis 55455,; USA.; Alloreactive T cells require costimulatory signals via CD40 ligand (CD40L). The tissue-destructive properties of allogeneic CD4+ but not CD8+ T cells were inhibited by anti-CD40L mAb. Fewer CD4+ thoracic duct lymphocytes (TDL) were obtained in mAb-treated recipients. Kinetic studies revealed that CD4+ T cell expansion
Antigen-driven but not lipopolysaccharide-driven IL-12 production in macrophages requires triggering of CD40.: J Immunol. 1997 Jan 1;158(1):359-66. Unique Identifier : AIDSLINE MED/97131710; DeKruyff RH; Gieni RS; Umetsu DT; Division of Immunology and Transplantation Biology, Department of; Pediatrics, Stanford University, CA 94305, USA.; We demonstrated that two distinct pathways exist for the induction of IL-12 in APC. The first pathway for IL-12 production occurred during responses to T cell-dependent Ags such as OVA and required triggering of CD40 molecules on the APC. IL-12 production in this T cell-dependent system increased in direct proportion
Priming with IFN-gamma restores deficient IL-12 production by peripheral blood mononuclear cells from HIV-seropositive donors.: J Immunol. 1997 Jan 1;158(1):459-63. Unique Identifier : AIDSLINE MED/97131722; Harrison TS; Levitz SM; Evans Memorial Department of Clinical Research, Boston University; Medical Center Hospital, MA 02118, USA.; Production of IL-12 is deficient in PBMC from HIV-infected individuals. Because of recent studies demonstrating that IFN-gamma priming increases the production of IL-12 in normal PBMC, we examined the role of IFN-gamma in the production of IL-12 in PBMC from HIV-seropositive donors. In response to Staphylococcus aureu
Evidence for B cell-mediated activation of V delta 1+ T lymphocytes during progression of HIV infection.: J Immunol. 1997 Jan 1;158(1):464-74. Unique Identifier : AIDSLINE MED/97131723; Hyjek EM; Bartkowiak J; Drozdz R; Wasik TJ; Jasinski M; Kaneko Y; Lischner HW; Kozbor D; Department of Microbiology and Immunology, Kimmel Cancer Center,; Thomas Jefferson University, Philadelphia, PA 19107, USA.; Progression of HIV-induced immunodeficiency is associated with both B cell activation and an increased proportion of Vdelta1+ T cells in PBL. To examine whether the peripheral expansion of Vdelta1+ cells is driven by activated B cells, we isolated CD19+ PBL from HIV+ individuals at different stages of infection and us
Chemotaxis and IL-8 receptor expression in B cells from normal and HIV-infected subjects.: J Immunol. 1997 Jan 1;158(1):475-84. Unique Identifier : AIDSLINE MED/97131724; Jinquan T; Moller B; Storgaard M; Mukaida N; Bonde J; Grunnet N; Black FT; Larsen CG; Matsushima K; Thestrup-Pedersen K; Department of Dermatology, University Hospital, Aarhus University,; Denmark.; To date, the activities of the alpha chemokines for human peripheral B cells from normal subjects (N-B cells) or from HIV-infected subjects (HIV-B cells) are not well established. No report on the IL-8R expression on N-B cells and HIV-B cells has been seen. We report in this work that the alpha chemokines IL-8 and gro
Patients with multidrug-resistant tuberculosis with low CD4+ T cell counts have impaired Th1 responses.: J Immunol. 1997 Jan 1;158(1):492-500. Unique Identifier : AIDSLINE MED/97131726; McDyer JF; Hackley MN; Walsh TE; Cook JL; Seder RA; Laboratory of Clinical Investigation, National Institute of Allergy; and Infectious Diseases, Bethesda, MD 20892, USA.; Multidrug-resistant tuberculosis (MDRTB) has emerged as a challenging clinical problem in both HIV-infected and -uninfected individuals. In this study, immune responses from HIV-negative patients with MDRTB were compared with those of healthy purified protein derivative (PPD)-positive and PPD-negative individuals. The
IL-16 represses HIV-1 promoter activity.: J Immunol. 1997 Jan 1;158(1):5-8. Unique Identifier : AIDSLINE MED/97131667; Maciaszek JW; Parada NA; Cruikshank WW; Center DM; Kornfeld H; Viglianti GA; The Program in Virology and Immunology, University of Massachusetts; Medical Center, Worcester 01605, USA.; IL-16 is produced by CD8+ lymphocytes and has been reported to inhibit HIV-1 and SIV replication in infected PBMCs. CD4 serves as a receptor for the secreted form of IL-16, and IL-16 binding to CD4 induces signal transduction, which affects the activation state of the cell. We hypothesized, therefore, that the effect
The state of maturation of monocytes into macrophages determines the effects of IL-4 and IL-13 on HIV replication.: J Immunol. 1997 Jan 1;158(1):501-11. Unique Identifier : AIDSLINE MED/97131727; Naif HM; Li S; Ho-Shon M; Mathijs JM; Williamson P; Cunningham AL; Westmead Institutes of Health Research, National Centre for HIV; Virology Reearch, University of Sydney, Australia.; The molecular mechanisms of the effects of IL-4 and IL-13 on HIV infection in human monocytes as they matured into monocyte-derived macrophages over 7 days were investigated using HIV-1(BaL), and low passage clinical strains. IL-4 and IL-13 up-regulated the expression of both genomic and spliced HIV mRNA in monocytes
Nuclear import of HIV-1 DNA in resting CD4+ T cells requires a cyclosporin A-sensitive pathway.: J Immunol. 1997 Jan 1;158(1):512-7. Unique Identifier : AIDSLINE MED/97131728; Sun Y; Pinchuk LM; Agy MB; Clark EA; Washington Regional Primate Research Center, University of Washington,; Seattle 98195, USA.; Using PCR to monitor early (LTR/LTR (long terminal repeat)) and late (LTR/gag) products of reverse transcription and the formation of HIV-1 LTR circles (indicating nuclear import), we explored the relationship between T cell activation signals and early events in the life cycle of HIV-1 infection. The combination of T
CD4 ligands inhibit the formation of multifunctional transduction complexes involved in T cell activation.: J Immunol. 1997 Jan 1;158(1):94-103. Unique Identifier : AIDSLINE MED/97131678; Jabado N; Pallier A; Le Deist F; Bernard F; Fischer A; Hivroz C; INSERM Unit 429, Necker-Enfants Malades Hospital, Paris, France.; Ligands binding to the CD4 molecule can inhibit TCR-mediated T cell activation. We have previously reported that transcription factors regulating the expression of the IL-2 gene, NF-AT, NF-kappaB, and AP-1, are targets of this inhibitory effect in an in vitro model usi
First report of Cryptococcus albidus septicaemia in an HIV patient.: J Infect. 1996 Sep;33(2):139-40. Unique Identifier : AIDSLINE MED/97044935; Loison J; Bouchara JP; Gueho E; de Gentile L; Cimon B; Chennebault JM; Chabasse D
Alveolar macrophage activation in HIV infection.: J Infect. 1996 Sep;33(2):91-4. Unique Identifier : AIDSLINE MED/97044924; Evans MR; Wansbrough-Jones MH; Division of Infectious Diseases, St. George's Hospital Medical School,; London, U.K.; Alveolar macrophage function is critical to the pulmonary immune response to infection. It is not known whether alveolar macrophages from HIV-infected individuals function normally in vivo. We have measured neopterin concentration, a marker of macrophage activation, in induced sputum, serum and saliva samples from con
The association between hepatitis C virus genotype and human immunodeficiency virus disease progression in a cohort of hemophilic men [see comments]: J Infect Dis. 1997 Jan;175(1):164-8. Unique Identifier : AIDSLINE MED/97138186; Sabin CA; Telfer P; Phillips AN; Bhagani S; Lee CA; Haemophilia Centre, Department of Haematology, Royal Free Hospital and; School of Medicine, London, United Kingdom.; Patients coinfected with both hepatitis C virus (HCV) and the human immunodeficiency virus (HIV) have more rapid progression of HCV infection; however, little is known about the effect of coinfection with HCV on the progression of HIV disease. This study assessed the association between infection with different HCV ge
Maternal virus load during pregnancy and mother-to-child transmission of human immunodeficiency virus type 1: the French perinatal cohort studies. SEROGEST Cohort Group.: J Infect Dis. 1997 Jan;175(1):172-5. Unique Identifier : AIDSLINE MED/97138188; Mayaux MJ; Dussaix E; Isopet J; Rekacewicz C; Mandelbrot L; Ciraru-Vigneron N; Allemon MC; Chambrin V; Katlama C; Delfraissy JF; Puel J; SEROGEST Cohort and Unite 292 INSERM, Hopital Kremlin Bicetre, France.; Virus load in pregnancy and its relation to mother-to-child human immunodeficiency virus (HIV) transmission were studied prospectively. From 1989 to 1994, 320 HIV-infected women from 18 centers had plasma samples stored. Among women not receiving antiretroviral therapy, the polymerase chain reaction RNA level was 3.6
Drug sensitivity of human immunodeficiency virus type 1 isolates after ribavirin therapy.: J Infect Dis. 1997 Jan;175(1):176-8. Unique Identifier : AIDSLINE MED/97138189; Bernier R; Tremblay M; Tsoukas C; Bergeron MG; Centre de Recherche en Infectiologie, Departement de Microbiologie,; Faculte de Medecine, Universite Laval, Ste-Foy, Montreal, Canada.; The antiviral agent ribavirin is effective against several virally induced diseases, and there is evidence that it might prove useful against human immunodeficiency virus type 1 (HIV-1) infection. Thus, there is interest in studying the resistance level of HIV-1 isolates to ribavirin following drug therapy. Low-passag
Cytomegalovirus gB genotype distribution differs in human immunodeficiency virus-infected patients and immunocompromised allograft recipients.: J Infect Dis. 1997 Jan;175(1):179-84. Unique Identifier : AIDSLINE MED/97138190; Rasmussen L; Hong C; Zipeto D; Morris S; Sherman D; Chou S; Miner R; Drew WL; Wolitz R; Dowling A; Warford A; Merigan TC; Center for AIDS Research, Division of Infectious Diseases and; Geographic Medicine, Stanford University School of Medicine, CA 94305,; USA. lucy.rasmussen@stanford.edu; Cytomegalovirus isolates can be grouped into 4 gB and 2 gH genotypes. gB genotypes were studied in patients infected with human immunodeficiency virus (HIV) and in allograft transplantation recipients. In allograft recipients, the distribution of gB 1, -2, -3, and -4 in leukocytes and urine, respectively, was 36%, 21%
Simian immunodeficiency virus-inoculated macaques acquire Mycobacterium avium from potable water during AIDS.: J Infect Dis. 1997 Jan;175(1):184-7. Unique Identifier : AIDSLINE MED/97138191; Mansfield KG; Lackner AA; New England Regional Primate Research Center, Harvard Medical School,; Southborough, Massachusetts 01772-9012, USA.; During the terminal stages of AIDS, Mycobacterium avium complex MAC) infection is the most common disseminated bacterial infection in rhesus macaques (Macaca mulatta) experimentally inoculated with the simian immunodeficiency virus (SIV). The source of mycobacterial infection in 15 SIV-inoculated rhesus macaques house
Polymorphisms within the human tumor necrosis factor-alpha promoter region in human immunodeficiency virus type 1-seropositive persons.: J Infect Dis. 1997 Jan;175(1):188-90. Unique Identifier : AIDSLINE MED/97138192; Brinkman BM; Keet IP; Miedema F; Verweij CL; Klein MR; Department of Rheumatology, University Hospital Leiden, Netherlands.; The question is addressed whether particular tumor necrosis factor-alpha (TNF-alpha) polymorphisms are associated with clinical course and outcome of human immunodeficiency virus type 1 (HIV-1) infection. The distribution of four TNF-alpha guanine G) to adenosine (A) transition polymorphisms at positions -376, 308, -2
Effect of Lactobacillus reuteri on intestinal resistance to Cryptosporidium parvum infection in a murine model of acquired immunodeficiency syndrome.: J Infect Dis. 1997 Jan;175(1):218-21. Unique Identifier : AIDSLINE MED/97138199; Alak JI; Wolf BW; Mdurvwa EG; Pimentel-Smith GE; Adeyemo O; Center For Biomedical Research and Department of Microbiology, School; of Veterinary Medicine, Tuskegee University, Alabama 36088, USA.; Efficacy of Lactobacillus reuteri as a probiotic for the control of Cryptosporidium parvum infection was evaluated in C57BL/6 female mice that were immunosuppressed by intraperitoneal inoculation with the LP-BM5 leukemia virus. Four months after inoculation, mice developed lymphadenopathy, splenomegaly, and susceptibi
Modulatory potential of iron chelation therapy on nitric oxide formation in cerebral malaria.: J Infect Dis. 1997 Jan;175(1):226-30. Unique Identifier : AIDSLINE MED/97138201; Weiss G; Thuma PE; Mabeza G; Werner ER; Herold M; Gordeuk VR; Department of Internal Medicine, University Hospital, University of; Innsbruck, Austria.; To determine whether iron chelation modulates nitric oxide (NO) formation and cell-mediated immune effector function in children with cerebral malaria, serum concentrations were measured of the stable end products of NO, nitrite and nitrate (NO2-/NO3-), interleukin (IL)-4, 6, and -10, and neopterin in 39 Zambian child
Appearance of autologous neutralizing antibody correlates with reduction in virus load and phenotype switch during primary infection with human immunodeficiency virus type 1 [letter; comment]: J Infect Dis. 1997 Jan;175(1):231-2. Unique Identifier : AIDSLINE MED/97138202; Lathey JL; Pratt RD; Spector SA
Cytokine pattern in relation to disease progression in human immunodeficiency virus-infected children.: J Infect Dis. 1997 Jan;175(1):47-56. Unique Identifier : AIDSLINE MED/97138169; Than S; Hu R; Oyaizu N; Romano J; Wang X; Sheikh S; Pahwa S; Department of Pediatrics, North Shore University Hospital-Cornell; University Medical College, Manhasset, New York 11030, USA.; Cytokine mRNA expression and stimulus-induced cytokines were examined in peripheral blood mononuclear cells in 62 human immunodeficiency virus (HIV)-infected children and uninfected controls. Compared with that in controls, constitutive mRNA expression in patients was increased for tumor necrosis factor TNF)-alpha, in
Genital shedding of human immunodeficiency virus type 1 DNA during pregnancy: association with immunosuppression, abnormal cervical or vaginal discharge, and severe vitamin A deficiency.: J Infect Dis. 1997 Jan;175(1):57-62. Unique Identifier : AIDSLINE MED/97138170; John GC; Nduati RW; Mbori-Ngacha D; Overbaugh J; Welch M; Richardson BA; Ndinya-Achola J; Bwayo J; Krieger J; Onyango F; Kreiss JK; Department of Pediatrics, University of Nairobi, Kenya.; The presence of human immunodeficiency virus type 1 (HIV-1) in genital secretions may be a determinant of vertical HIV-1 transmission. Cervical and vaginal secretions from HIV-1-seropositive pregnant women were evaluated to determine prevalence and correlates of HIV-1-infected cells in the genital tract. HIV-1 DNA was
Vertical transmission of human immunodeficiency virus type 1: seroreactivity by maternal antibodies to the carboxy region of the gp41 envelope glycoprotein.: J Infect Dis. 1997 Jan;175(1):63-9. Unique Identifier : AIDSLINE MED/97138171; Ugen KE; Srikantan V; Goedert JJ; Nelson RP Jr; Williams WV; Weiner DB; Department of Medical Microbiology and Immunology, University of South; Florida College of Medicine, Tampa 33612, USA.; Maternal antibodies against the envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) have previously been suggested to be important in influencing the rate of vertical transmission. In this study, serum antibody responses in mothers who did or did not transmit HIV-1 infection to their children were mea
Lineage commitment in the thymus: only the most differentiated TCRhibcl-2hi) subset of CD4+CD8+ thymocytes has selectively terminated CD4 or CD8 synthesis.: J Exp Med. 1996 Dec 1;184(6):2091-9. Unique Identifier : AIDSLINE MED/97130403; Punt JA; Suzuki H; Granger LG; Sharrow SO; Singer A; Experimental Immunology Branch, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland, USA.; Lineage commitment is a developmental process by which individual CD4+CD8+ (double positive, DP) thymocytes make a decision to differentiate into either CD4+ or CD8+ T cells. However, the molecular event(s) that defines lineage commitment is controversial. We have previously proposed that lineage commitment in DP thym
Induction of murine acquired immunodeficiency syndrome (MAIDS) in allophenic mice generated from strains susceptible and resistant to disease.: J Exp Med. 1996 Dec 1;184(6):2101-8. Unique Identifier : AIDSLINE MED/97157291; Sechler JM; Lawler A; Hartley JW; Morse HC 3rd; McCarty TC; Swofford R; Rosenberg AS; Division of Hematologic Products, Food and Drug Administration,; Bethesda, Maryland 20892, USA.; To examine whether a retroviral disease can be controlled in animals in which cells from a resistant strain coexist in a state of immunological tolerance with cells from a susceptible strain, allophenic mice were constructed and infected with LP-BM5 murine leukemia viruses which induce a fatal disorder, termed murine
Apoptosis of Fashigh CD4+ synovial T cells by borrelia-reactive Fas-ligand(high) gamma delta T cells in Lyme arthritis.: J Exp Med. 1996 Dec 1;184(6):2109-17. Unique Identifier : AIDSLINE MED/97130404; Vincent MS; Roessner K; Lynch D; Wilson D; Cooper SM; Tschopp J; Sigal LH; Budd RC; Department of Medicine, University of Vermont College of Medicine,; Burlington 05405-0068, USA.; The function of the minor subset of T lymphocytes bearing the gamma delta T cell antigen receptor is uncertain. Although some gamma delta T cells react to microbial products, responsiveness has only rarely been demonstrated toward a bacterial antigen from a naturally occurring human infection. Synovial fluid lymphocyt
Resting memory CD8+ T cells are hyperreactive to antigenic challenge in vitro.: J Exp Med. 1996 Dec 1;184(6):2141-51. Unique Identifier : AIDSLINE MED/97130407; Pihlgren M; Dubois PM; Tomkowiak M; Sjogren T; Marvel J; Laboratoire de Biologie Moleculaire et Cellulaire de Ecole Normale; Superieure Lyon centre National de la Recherche Scientifique Unite; Mixte de Recherche, France.; The characteristics of CD8+ T cells responsible for memory responses are still largely unknown. Particularly, it has not been determined whether different activation thresholds distinguish naive from memory CD8+ T cell populations. In most experimental systems, heterogeneous populations of primed CD8+ T cells can be i
Aerosol insulin induces regulatory CD8 gamma delta T cells that prevent murine insulin-dependent diabetes.: J Exp Med. 1996 Dec 1;184(6):2167-74. Unique Identifier : AIDSLINE MED/97130409; Harrison LC; Dempsey-Collier M; Kramer DR; Takahashi K; Walter and Eliza Hall Institute of Medical Research, Royal Melbourne; Hospital, Parkville, Australia.; Cellular immune hyporesponsiveness can be induced by the presentation of soluble protein antigens to mucosal surfaces. Most studies of mucosa-mediated tolerance have used the oral route of antigen delivery and few have examined autoantigens in natural models of autoimmune disease. Insulin is an autoantigen in humans a
Systemic T cell-independent tumor immunity after transplantation of universal receptor-modified bone marrow into SCID mice.: J Exp Med. 1996 Dec 1;184(6):2261-9. Unique Identifier : AIDSLINE MED/97130418; Hege KM; Cooke KS; Finer MH; Zsebo KM; Roberts MR; Department of Immunology and Cell Biology, Cell Genesys Inc., Foster; City, California 94404, USA.; Gene modification of hematopoietic stem cells (HSC) with antigen-specific, chimeric, or universal immune receptors (URs) is a novel but untested form of targeted immunotherapy. A human immunodeficiency virus (HIV) envelope-specific UR consisting of the extracellular domain of human CD4 linked to the zeta chain of th
Antagonist HIV-1 Gag peptides induce structural changes in HLA B8.: J Exp Med. 1996 Dec 1;184(6):2279-86. Unique Identifier : AIDSLINE MED/97130420; Reid SW; McAdam S; Smith KJ; Klenerman P; O'Callaghan CA; Harlos K; Jakobsen BK; McMichael AJ; Bell JI; Stuart DI; Jones EY; Laboratory of Molecular Biophysics, Oxford, United Kingdom.; SCOTT@BIOP.OX.AC.UK; In the cellular immune response, recognition by CTL-TCRs of viral antigens presented as peptides by HLA class I molecules, triggers destruction of the virally infected cell (Townsend, A.R.M., J. Rothbard, F.M. Gotch, G. Bahadur, D. Wraith, and A.J. McMichael. 1986. Cell. 44:959-968). Altered peptide ligands (APLs) whi
Cross-linking of Fas by antibodies to a peculiar domain of gp120 V3 loop can enhance T cell apoptosis in HIV-1-infected patients.: J Exp Med. 1996 Dec 1;184(6):2287-300. Unique Identifier : AIDSLINE MED/97130421; Silvestris F; Nagata S; Cafforio P; Silvestris N; Dammacco F; Department of Biomedical Sciences and Human Oncology, University of; Bari, Italy.; Previous studies have demonstrated that T cell-reactive antibodies in HIV-1 infection contribute to lymphocyte depletion by cytotoxicity that involves differential membrane targets, such as the 43.5-kD receptor on CEM cells. Here, we show that these antibodies bind Fas as result of a molecular mimicry of the gp120. Bo
Efficient interaction of HIV-1 with purified dendritic cells via multiple chemokine coreceptors.: J Exp Med. 1996 Dec 1;184(6):2433-8. Unique Identifier : AIDSLINE MED/97130437; Granelli-Piperno A; Moser B; Pope M; Chen D; Wei Y; Isdell F; O'Doherty U; Paxton W; Koup R; Mojsov S; Bhardwaj N; Clark-Lewis I; Baggiolini M; Steinman RM; Theodor Kocher Institute, Bern, Switzerland.; HIV-1 actively replicates in dendritic cell (DC)-T cell cocultures, but it has been difficult to demonstrate substantial infection of purified mature DCs. We now find that HIV-1 begins reverse transcription much more efficiently in DCs than T cells, even though T cells have higher levels of CD4 and gp120 binding. DCs
Copper(II) interactions with an experimental antiviral agent, I-deoxynojirimycin, and oxygen activation by resulting complexes.: J Inorg Biochem. 1996 Dec;64(4):231-46. Unique Identifier : AIDSLINE MED/97073703; Jezowska-Bojczuk M; Bal W; Kasprzak KS; Laboratory of Comparative Carcinogenesis, National Cancer Institute,; Frederick Cancer Research and Development Center, Maryland, USA.; 1-deoxynojirimycin (DNJ), a 5-imino analog of 1-deoxyglucose, is a potent inhibitor of alpha-glucosidase 1. DNJ and its derivatives have been considered as experimental drugs against human HIV-1 and hepatitis B viruses. Since amino and imino ligands have a high affinity for copper, it seems possible that biological ac
Massage therapy improves behavior in neonates born to HIV-positive mothers.: J Pediatr Psychol. 1996 Dec;21(6):889-97. Unique Identifier : AIDSLINE MED/97145059; Scafidi F; Field T; Touch Research Institute, University of Miami School of Medicine,; Florida 33101, USA.; Assigned randomly 28 neonates born to HIV-positive mothers to a massage therapy or control group. The treatment infants were given three 15-minute massages daily for 10 days. The massaged group showed superior performance on almost every Brazelton newborn cluster score and had a greater daily weight gain at the end of
Solid phases of delavirdine mesylate.: J Pharm Sci. 1996 Aug;85(8):834-41. Unique Identifier : AIDSLINE MED/97016647; Bergren MS; Chao RS; Meulman PA; Sarver RW; Lyster MA; Havens JL; Hawley M; Pharmacia and Upjohn Inc., Kalamazoo, MI 49001, USA.; Delavirdine mesylate was recrystallized from solution under a variety of conditions. Seven crystal forms and a stable amorphous phase were isolated from solution. Two of these crystal forms were polymorphic anhydrates: from XI (U-90152T) and form VIII
High-performance liquid chromatographic analysis of 2'-fluoro-2',3'-dideoxyadenosine and 2'-fluoro-2',3'-dideoxyinosine in dog plasma and urine.: J Pharm Sci. 1996 Aug;85(8):890-2. Unique Identifier : AIDSLINE MED/97016658; Campbell DA; Shah VR; Srinivas NR; Shyu WC; Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb; Pharmaceutical Research Institute, Bristol-Myers Squibb Company,; Princeton, NJ 08543, USA.; A high-performance liquid chromatographic assay was developed and validated for a simulataneous determination of 2 -fluoro-2 3 -dideoxyadenosine (FddA) and its metabolite, 2 -fluoro-2 ,3 -dideoxyinosine (Fddl) in dog plasma and urine. In vitro, FddA and Fddl exhibit activity against human immunodeficiency virus (HIV)
Colposcopic biopsies versus loop electrosurgical excision procedure cone histology in human immunodeficiency virus-positive women.: J Reprod Med. 1996 Sep;41(9):653-7. Unique Identifier : AIDSLINE MED/97041918; Del Priore G; Gilmore PR; Maag T; Warshal DP; Cheon TH; Department of Obstetrics and Gynecology, New York University School of; Medicine, New York, USA.; OBJECTIVE: To compare the discrepancy between colposcopically directed punch biopsy and excisional cone biopsy in human immunodeficiency-positive (HIV+) vs. HIV-negative (HIV-) women. STUDY DESIGN: We performed a case-control analysis of women treated with excisional cone biopsy after an abnormal colposcopic punch bio
Synthesis and bioactivity of novel bis(heteroaryl)piperazine BHAP) reverse transcriptase inhibitors: structure-activity relationships and increased metabolic stability of novel substituted pyridine analogs.: J Med Chem. 1996 Dec 20;39(26):5267-75. Unique Identifier : AIDSLINE MED/97133459; Genin MJ; Poel TJ; Yagi Y; Biles C; Althaus I; Keiser BJ; Kopta LA; Friis JM; Reusser F; Adams WJ; Olmsted RA; Voorman RL; Thomas RC; Romero DL; Pharmacia & Upjohn, Kalamazoo, Michigan 49001, USA.; The major route of metabolism of the bis(heteroaryl)piperazine BHAP) class of reverse transcriptase inhibitors (RTIs), atevirdine and delavirdine , is via oxidative N-dealkylation of the 3-ethyl- or 3-isopropylamino substituent on the pyridine ring. Th
Synthesis and HIV inhibition activity of 2',3'-dideoxy-3'-C-hydroxymethyl nucleosides.: J Med Chem. 1996 Dec 20;39(26):5276-80. Unique Identifier : AIDSLINE MED/97133460; Lee-Ruff E; Ostrowski M; Ladha A; Stynes DV; Vernik I; Jiang JL; Wan WQ; Ding SF; Joshi S; Department of Chemistry, York University, Toronto, Ontario, Canada.; A series if 2 ,3 -dideoxy-3 -C-hydroxymethyl purine nucleosides were prepared based on the photochemical ring expansion of a chiral cyclobutanone precursor, 2S)-trans-2,3-bis[(benzoyloxy)methyl]cyclobutanone, in the presence of a 6-substituted purine. Both alpha- and beta-anomers are produced in this transformation. D
A brief survey of the current sexual practices of a population admitted for inpatient treatment of drug dependence.: J Sex Marital Ther. 1996 Fall;22(3):203-8. Unique Identifier : AIDSLINE MED/97034997; Burke WM; Dhopesh V; Lainfester C; HealthPro/United HealthCare, Westborough, MA 01581, USA.; We studied a population of high-risk drug users concerning their current sexual practices. They had a pattern of inconsistent or infrequent condom use. Only 11.5% reported always using condoms; 38.2% reported never using them; and 50.3% reported using them sometimes. Experimental educational programs have demonstrated
[Large granular lymphocyte leukemia]: Rinsho Byori. 1996 Oct;44(10):917-26. Unique Identifier : AIDSLINE MED/97091506; Mizuki M; Tagawa S; Shibano M; Hirota T; Machii T; Kitani T; Ohsawa M; Aozasa K; Nojima J; Department of Hematology and Oncology, Osaka University Medical; School, Suita.; Large granular lymphocyte leukemia (LGLL) is defined as clonal proliferation of LGLs in peripheral blood. The following studies were conducted to address some issues in chronic LGLL. (1) Chronic LGLL is characterized by the indolent course, and the diagnosis of leukemia is difficult in such patients as those without d
[Future prospects of emergency laboratory tests--problems of immunoserologic tests]: Rinsho Byori. 1996 Oct;44(10):956-61. Unique Identifier : AIDSLINE MED/97091512; Obana Y; Furuta I; Ohba Y; Department of Clinical Pathology, Kinki University School of Medicine,; Osaka-Sayama.; Regarding problems in emergency and urgent immunoserologic tests, I mainly focused on infectious diseases and CPR and discussed the correspondence of dangerous needle stick injuries, and the significance of emergency CRP measurement in various body fluids using highly sensitive determination methods. The actual condit
Predictors of HIV-related risk behaviors among heterosexuals in alcoholism treatment.: J Stud Alcohol. 1996 Sep;57(5):486-93. Unique Identifier : AIDSLINE MED/97011536; Woods WJ; Avins AL; Lindan CP; Hudes ES; Boscarino JA; Clark WW; Center for AIDS Prevention Studies, University of California, San; Francisco 94105, USA.; OBJECTIVE: To determine which measures of alcohol and drug use are associated with HIV-related sexual risk and protective behaviors. METHOD: Entrants (N = 743, 72% male) to alcoholism treatment clinics underwent a structured interview including an assessment of demographics, substance abuse characteristics and sexual
[Rates of human immunodeficiency virus (HIV) infection in intravenous drug addicts from the Barcelona area, according to sex and age of drug consumption onset]: Med Clin (Barc). 1996 Jan 27;106(3):87-90. Unique Identifier : AIDSLINE MED/97106194; Egea JM; Tor J; Muga R; Roca J; Rodriguez R; Navio M; Rey-Joly C; Unidad de Desintoxicacion, Hospital Universitario Germans Trias i; Pujol, Barcelona.; BACKGROUND: The differences in the rates of HIV infection in intravenous drug addicts according to the age of onset of drug consumption, sex and length of intake were evaluated. METHODS: The study sample was made up of 650 intravenous drug addicts (535 males and 115 females) admitted to a Hospital Detoxication Unit ov
[Intestinal occlusion caused by ileocolic tuberculosis in a patient with human immunodeficiency virus infection (letter)]: Med Clin (Barc). 1996 Feb 3;106(4):157. Unique Identifier : AIDSLINE MED/97106190; Rodriguez Rodriguez E; Hernando Alonso J; Prieto de Paula JM; Arribas Escobar V
Enhanced engraftment of HTLV-I-infected human T cells in severe combined immunodeficiency mice by anti-asialo GM-1 antibody treatment.: Microbiol Immunol. 1996;40(1):39-44. Unique Identifier : AIDSLINE MED/97025315; Ishihara S; Okayama A; Nagatomo Y; Murai K; Yamashita R; Okamoto M; Shima T; Sasaki T; Mueller N; Tachibana N; Tsubouchi H; Second Department of Internal Medicine, Miyazaki Medical College,; Japan.; The effects of anti-asialo GM-1 antibody (AAGM) treatment on the engraftment of human T-cell leukemia virus type I HTLV-I)-infected human T cells in severe combined immunodeficiency (SCID) mice were studied. The frequency of tumor formation in an HTLV-I-transformed human T-cell line, MT-2 cells, at the site of inocula
A study of two procedures of HIV-1 isolation from whole blood cultures.: Microbiol Immunol. 1996;40(3):195-200. Unique Identifier : AIDSLINE MED/97088765; Shen L; Hober D; Benyoucef S; Ajana F; Gerard Y; Lion G; Vermersch A; Bocket-Mouton L; Mouton Y; Wattre P; Laboratoire de Virologie, Bat IRFPPS, CHU, Lille, France.; Culture techniques for isolation of HIV-1 from small amounts of whole blood (WB) treated with anticoagulant have been reported and gave results identical to those of culture of separated peripheral blood mononuclear cells. Some authors obtained much higher isolation rates when EDTA was used instead of heparin. We comp
Absence of human T-cell lymphotropic virus type I in cutaneous T-cell lymphoma [letter]: N Engl J Med. 1997 Jan 23;336(4):296-7. Unique Identifier : AIDSLINE MED/97136558; Kikuchi A; Nishikawa T; Yamaguchi K
Russian records rise in HIV [news]: Nature. 1997 Jan 9;385(6612):108. Unique Identifier : AIDSLINE MED/97144336
Applying viral load measurements to HIV care.: Nurse Pract. 1996 Aug;21(8):102-4. Unique Identifier : AIDSLINE MED/97025815; Klaus BD
Occupationally acquired HIV in health care workers [letter]: Nurse Pract. 1996 Sep;21(9):6-8, 11. Unique Identifier : AIDSLINE MED/97039236; Gershon RM; Byrns GE; Dunleavy ML
Evolution of tumor necrosis factor-alpha serum concentrations in HIV infected individuals treated with zidovudine.: Pathol Biol (Paris). 1996 Oct;44(8):716-9. Unique Identifier : AIDSLINE MED/97132476; Morlat P; Chene G; Ragnaud JM; Mercie P; Grobost F; Bernard N; Lacoste D; Beylot J; Aubertin J; Internal Medicine Department, Saint Andre Hospital, Bordeaux, France.; We studied the evolution of Tumor Necrosis Factor-alpha serum concentration (TNF-alpha) and CD4+ lymphocyte counts (CD4+) in a pilot cohort study of HIV-infected patients during the first year of zidovudine therapy. Data on 17 patients remaining asymptomatic during the one-year follow-up period (non progressors) were
Empyema with malakoplakic-like lesions by Rhodococcus equi as a presentation of HIV infection.: Pathologica. 1995 Oct;87(5):525-27. Unique Identifier : AIDSLINE MED/97021820; Calore EE; Vazquez CR; Perez NM; Cavaliere MJ; Curti R Jr; Campos Salles PS; Araujo MF; Instituto de Infectologia Emilio Ribas, S. Anatomia Patologica, S.; Paulo, Brazil.; Rhodococcus equi (Corynebacterium equi) is an aerobic actinomycetes, well described as a cause of pulmonary infection in different animals as horses, pigs and cows. This pathogen has a coccobacillar aspect and a variable acid-fast stain in tissues. Rare cases of human infection by Rhodococcus species were described, t
Characterization of natural killer and antibody-dependent cellular cytotoxicity of preterm infants against human immunodeficiency virus-infected cells.: Pediatr Res. 1996 Sep;40(3):498-503. Unique Identifier : AIDSLINE MED/97018674; Merrill JD; Sigaroudinia M; Kohl S; Department of Pediatrics, University of California, San Francisco,; USA.; The odds risk of vertical transmission of human immunodeficiency virus (HIV) to preterm infants is almost four times that of term infants and may relate to maternal and neonatal factors. We characterized the competence of early nonspecific cellular immunity, namely natural killer cytotoxicity (NKC) and antibody-depend
Bug busters [news]: Nurs Times. 1996 Nov 6-12;92(45):20-1. Unique Identifier : AIDSLINE MED/97154124; Cole A
Availability of HIV testing for pregnant women [news]: Nurs Times. 1996 Nov 13-19;92(46):15. Unique Identifier : AIDSLINE MED/97154139; MacDonagh SE
Nurses' Day at Rashtrapati Bhavan.: Nurs J India. 1996 Jul;87(7):146-7. Unique Identifier : AIDSLINE MED/97152110; Hind J
Comparison of changing autopsy trends in the Bronx population with acquired immunodeficiency syndrome.: Mod Pathol. 1996 Oct;9(10):1001-6. Unique Identifier : AIDSLINE MED/97058519; Concepcion L; Markowitz GS; Borczuk AC; Factor SM; Department of Pathology, Albert Einstein College of Medicine, Bronx,; New York 10461, USA.; The opportunistic infections, malignancies, and causes of death related to acquired immunodeficiency syndrome (AIDS) are changing, perhaps as a result of improved treatment, prophylaxis, and education. With its high percentage of persons who acquired the human immunodeficiency virus from intravenous drug (IVD) use, th
Digestive leishmaniasis in acquired immunodeficiency syndrome: a light and electron microscopic study of two cases.: Mod Pathol. 1996 Oct;9(10):966-9. Unique Identifier : AIDSLINE MED/97058513; Zimmer G; Guillou L; Gauthier T; Iten A; Saraga EP; Institute of Pathology, University Hospital, Lausanne, Switzerland.; An increased incidence of visceral leishmaniasis in patients infected with the human immunodeficiency virus (HIV) is observed in areas in which both infectious diseases are endemic. Intensive worldwide traveling has also resulted recently in an increasing number of leishmanial and HIV coinfections in nonendemic areas.
Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding.: Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15030-5. Unique Identifier : AIDSLINE MED/97140276; Wu H; Myszka DG; Tendian SW; Brouillette CG; Sweet RW; Chaiken IM; Hendrickson WA; Department of Biochemistry and Molecular Biophysics, Columbia; University, New York, NY 10032, USA.; The T-cell antigen coreceptor CD4 also serves as the receptor for the envelope glycoprotein gp120 of HIV. Extensive mutational analysis of CD4 has implicated residues from a portion of the extracellular amino-terminal domain (D1) in gp120 binding. However, none of these proteins has been fully characterized biophysica
Transduction of nondividing cells using pseudotyped defective high-titer HIV type 1 particles.: Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15266-71. Unique Identifier : AIDSLINE MED/97140318; Reiser J; Harmison G; Kluepfel-Stahl S; Brady RO; Karlsson S; Schubert M; Molecular and Medical Genetics Section, National Institute of; Neurological Disorders and Stroke, National Institutes of Health,; Bethesda, MD 20892, USA. jreiser@helix.nih.gov; The use of Moloney murine leukemia virus (Mo-MLV)-based vectors to deliver therapeutic genes into target cells is limited by their inability to transduce nondividing cells. To test the capacity of HIV-based vectors to deliver genes into nondividing cells, we have generated replication-defective HIV type 1 (HIV-1) repo
Cytotoxic T lymphocytes and viral turnover in HIV type 1 infection.: Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15323-8. Unique Identifier : AIDSLINE MED/97140329; Klenerman P; Phillips RE; Rinaldo CR; Wahl LM; Ogg G; May RM; McMichael AJ; Nowak MA; Nuffield Department of Medicine, John Radcliffe Hospital, Oxford,; United Kingdom.; To understand the role of the immune system in limiting HIV type 1 replication, it is critical to know to what extent the rapid turnover of productively infected cells is caused by viral cytopathicity or by immune-mediated lysis. We show that uncultured peripheral blood mononuclear cells of many patients contain cytot
CD8+ T-cell-derived soluble factor(s), but not beta-chemokines RANTES, MIP-1 alpha, and MIP-1 beta, suppress HIV-1 replication in monocyte/macrophages.: Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15341-5. Unique Identifier : AIDSLINE MED/97140332; Moriuchi H; Moriuchi M; Combadiere C; Murphy PM; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892, USA.; It has been demonstrated that CD8+ T cells produce a soluble factor(s) that suppresses human immuno-deficiency virus (HIV) replication in CD4+ T cells. The role of soluble factors in the suppression of HIV replication in monocyte/macrophages (M/M) has not been fully delineated. To investigate whether a CD8+ T-cell-der
Sensitivity to inhibition by beta-chemokines correlates with biological phenotypes of primary HIV-1 isolates.: Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15382-7. Unique Identifier : AIDSLINE MED/97140339; Jansson M; Popovic M; Karlsson A; Cocchi F; Rossi P; Albert J; Wigzell H; Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm,; Sweden.; Primary HIV-1 isolates were evaluated for their sensitivity to inhibition by beta-chemokines RANTES (regulated upon activation, normal T-cell expressed and secreted), macrophage inflammatory protein 1 alpha (MIP-1 alpha), and MIP-1 beta. Virus isolates of both nonsyncytium-inducing (NSI) and syncytium-inducing (SI) bi
Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein.: Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15394-9. Unique Identifier : AIDSLINE MED/97140341; Farci P; Shimoda A; Wong D; Cabezon T; De Gioannis D; Strazzera A; Shimizu Y; Shapiro M; Alter HJ; Purcell RH; Hepatitis Viruses Section, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892, USA.; The identification of the neutralization domains of hepatitis C virus (HCV) is essential for the development of an effective vaccine. Here, we show that the hypervariable region 1 (HVR1) of the envelope 2 (E2) protein is a critical neutralization domain of HCV. Neutralization of HCV in vitro was attempted with a rabbi
The relevance of opioids and opioid receptors on immunocompetence and immune homeostasis.: Proc Soc Exp Biol Med. 1996 Dec;213(3):248-57. Unique Identifier : AIDSLINE MED/97138282; Carr DJ; Rogers TJ; Weber RJ; Department of Microbiology, LSU Stanley S. Scott and Neuroscience; Centers, LSU Medical Center, New Orleans, Louisiana 70112-1393, USA.; Since the previous review on the role of opioids in the immune system, numerous investigative teams have contributed to the growing pool of information illustrating the tangible relationship between opioids and immune function, particularly as this association pertains to bacterial and viral pathogens. In addition, th
Effect of 5-alpha dihydrotestosterone on T-cell proliferation of the female nonobese diabetic mouse.: Proc Soc Exp Biol Med. 1996 Dec;213(3):287-93. Unique Identifier : AIDSLINE MED/97138288; Toyoda H; Takei S; Formby B; Division of Medical Genetics, Cedars-Sinai Medical Center, University; of California, Los Angeles, School of Medicine, 90048, USA.; Nonobese diabetic (NOD) mice develop type I diabetes spontaneously and have been utilized as a model for human autoimmune insulin-dependent diabetes. The disease is caused by the destruction of insulin-producing beta cells in the pancreatic islet of Langerhans by infiltrating inflammatory cells, which are primarily T
Posttraumatic stress disorder and illness behaviour in HIV+ patients.: Psychol Rep. 1996 Dec;79(3 Pt 1):843-5. Unique Identifier : AIDSLINE MED/97123861; Botha KF; Department of Psychology, Potchefstroom University for Christian; Higher Education, Vanderbijlpark, South Africa.; 24 asymptomatic HIV+ patients completed the Impact of Event Scale and the Illness Behaviour Questionnaire. Analysis indicated above-average scores on posttraumatic stress reactions as well as significant intercorrelations of this score with scores on three factors on the Illness Behaviour Questionnaire, namely, hypoch
Psychosocial factors in HIV-AIDS [editorial]: Psychother Psychosom. 1996;65(5):225-8. Unique Identifier : AIDSLINE MED/97048487; Emmelkamp PM
[Pseudomonas aeruginosa: dreadful also in the AIDS patient editorial)]: Rev Clin Esp. 1996 Oct;196(10):670-1. Unique Identifier : AIDSLINE MED/97122750; Bouza E
[Prevalence of the genotypes of the hepatitis C virus in Spanish drug addicts with chronic hepatitis C. Spanish Group for the Study of Viral Hepatitis in HIV Positive Patients]: Rev Clin Esp. 1996 Oct;196(10):673-7. Unique Identifier : AIDSLINE MED/97122751; Bravo R; Soriano V; Garcia-Samaniego J; Gonzalez J; Castro A; Colmenero M; Carballo E; Mas A; Gonzalez-Lahoz J; Instituto de Salud Carlos III. Madrid.; The hepatitis C virus (HCV) shows a wide genetic variability. The different variants of HCV have been classified into 9 types and different subtypes. Some genotypes have a characteristic geographic distribution and seem to be associated with precise ways of contagion. Serum samples from 107 spanish patients with chron
[Respiratory infection caused by Pseudomonas aeruginosa in patients with HIV infection]: Rev Clin Esp. 1996 Oct;196(10):678-83. Unique Identifier : AIDSLINE MED/97122752; Arrizabalaga Aguirreazaldegui J; Horcajada Gallego JP; Mentxaka Ugalde B; Rodriguez Arrondo F; Iribarren Loyarte JA; von Wichman de Miguel M; Garde Orbaiz C; Unidad de Enfermedades Infecciosas, Hospital Nuestra Senora de; Aranzazu, San Sebastian.; OBJECTIVE: Descriptive study of severe respiratory infections caused by Pseudomonas aeruginosa in patients with HIV infection. METHODS: Review of clinical records of HIV-positive patients admitted in a tertiary hospital from 1-1-1990 to 9-30-1995. The patients included in this study were those with P. aeruginosa recov
[Pseudomonas aeruginosa bacteremia in patients with HIV infection: clinicoepidemiologic study of 17 episodes]: Rev Clin Esp. 1996 Oct;196(10):684-91. Unique Identifier : AIDSLINE MED/97122753; Salavert Lleti S; Navarro Ibanez V; Roig Rico P; Breton Martinez JR; Ponz Diez F; Lopez Aldeguer J; Gobernado Serrano M; Servicio de Microbiologia Clinica, Hospital Universitario La Fe,; Valencia.; BACKGROUND: Bacteremic infection with Pseudomonas aeruginosa is an uncommon and late phenomenon in the natural history of infection with human immunodeficiency virus (HIV). Our objective was to study the clinico-epidemiological characteristics of P. aeruginosa bacteremia (PAB) in patients infected with HIV. PATIENTS A
[The spectrum of bronchopulmonary infection caused by Pseudomonas aeruginosa in patients infected with the human immunodeficiency virus]: Rev Clin Esp. 1996 Oct;196(10):692-7. Unique Identifier : AIDSLINE MED/97122754; Santin Cerezales M; Aranda Sanchez M; Podzamczer Palter D; Maiques Llacer JM; Rufi Rigau G; Gudiol Munte F; Servicio de Enfermedades Infecciosas, Ciutat Sanitaria i Universitaria; de Bellvitge, L'Hospitalet, Barcelona.; OBJECTIVE: To describe the clinical spectrum of bronchopulmonary infections caused by Pseudomonas aeruginosa in patients infected with HIV. METHODS: A retrospective study of cases with P. aeruginosa pneumonia and tracheo-bronchitis in patients infected with HIV, diagnosed over a 5-year period (January 1990-December 19
[Bacteremia caused by Pseudomonas aeruginosa in patients with AIDS]: Rev Clin Esp. 1996 Oct;196(10):698-702. Unique Identifier : AIDSLINE MED/97122755; Bouza Santiago E; Blazquez Garrido R; Rodriguez-Creixems M; Moreno Guillen S; Miralles Martin P; Alonso Fernandez R; Servicio de Microbiologia y Enfermedades Infecciosas, Hospital General; Universitario Gregorio Maranon, Madrid.; Severe infections caused by Pseudomonas aeruginosa are uncommon in patients infected with HIV. These infections are usually recurrent, bear a poor prognosis and their potential for nosocomial transmission is questioned. From May 1991 to December 1994, a total of 2,739 admissions were recorded at the VIH Unit in our ho
[Vasculitis associated with HIV infection]: Rev Clin Esp. 1996 Oct;196(10):714-20. Unique Identifier : AIDSLINE MED/97122759; Fernandez-Miranda Parra C; Rubio Garcia R; Pulido Ortega F; Servicio de Medicina Interna, Hospital Universitario 12 de Octubre,; Madrid.
[Usefulness of the bone marrow examination in HIV infected patients (letter)]: Rev Clin Esp. 1996 Oct;196(10):728-30. Unique Identifier : AIDSLINE MED/97122766; Moreno Garcia M
The emergence of HIV/AIDS in Africa.: Rev Epidemiol Sante Publique. 1996 Nov;44(6):511-8. Unique Identifier : AIDSLINE MED/97140653; De Cock KM; London School of Hygiene and Tropical Medicine, United Kingdom.; The recent spread of HIV/AIDS in Africa must be seen in the broader context of emerging infectious diseases, whose epidemiology results from changes in the equilibrium between the agent, the host, and the environment. For sexually transmitted agents such as HIV, epidemic spread requires a high basic reproductive rate
Signal transduction as target of gene therapy.: Recent Results Cancer Res. 1996;142:63-71. Unique Identifier : AIDSLINE MED/97048499; Moelling K; Strack B; Radziwill G; Institute of Medical Virology, University of Zurich, Switzerland.; Cancer development involves multistep events. Therapeutic approaches can be targeted against any of these events individually or in combination. Pancreatic cancer can involve activation of Ki-Ras, overexpression of Myc or ErbB-2, and mutational inactivation of functional p53. Three approaches with nucleic acid-based t
[Lymphotropic viruses type I and II in pregnant women in Yucatan]: Rev Invest Clin. 1996 Sep-Oct;48(5):383-4. Unique Identifier : AIDSLINE MED/97122794; Gongora-Biachi RA; Gonzalez-Martinez P; Castro-Sansores C; Vivas-Rosel ML; Gasque-Lopez F; Garrido-Hadad E; Laboratorio de Hematologia, entro de Investigaciones Regionales Dr.; Hideyo Noguchi, Universidad Autonoma de Yucatan, Merida, Yucatan,; Mexico.; No antibodies against HTLV-I and HTLV-II were detected in 590 gestating women residing in the Yucatan peninsula sampled between Jan/92 and May/93.
Human immunodeficiency-virus-related pulmonary infections in children.: Semin Respir Infect. 1996 Sep;11(3):173-83. Unique Identifier : AIDSLINE MED/97037528; McSherry GD; Department of Pediatrics, UMD-New Jersey Medical School, Newark, USA.; Increasing numbers of children with human immunodeficiency virus HIV) infection continue to be seen in the United States . Pulmonary infections constitute a major cause of morbidity and mortality in these children Pneumoncystis carinii pneumonia, pulmonary lymphoid hyperplasia/lymphoid
Analysis of uncontrolled treatment changes in HIV clinical trails.: Stat Med. 1996 Oct 15;15(19):2053-67. Unique Identifier : AIDSLINE MED/97051413; Lin HM; Hughes MD; Research Department, United Network for Organ Sharing, Richmond, VA; 23225, USA.; Some clinical trials involving subjects with the human immunodeficiency virus (HIV) allow a subject to change treatment when a marker of disease progression, for example, the CD4 cell count, falls below a defined threshold. Although the change does not involve a randomized control, there is considerable interest in as
[The eye and AIDS: ophthalmological consultation for AIDS screening, 1-year retrospective study]: Rev Med Suisse Romande. 1996 Jan;116(1):59-64. Unique Identifier : AIDSLINE MED/97025052; Lendi B; Herbort CP; Hopital ophtalmique Jules Gonin, Lausanne.
[Epidemiology of sexually transmitted diseases, with the exception of AIDS]: Rev Prat. 1996 Oct 15;46(16):1940-7. Unique Identifier : AIDSLINE MED/97132748; Warszawski J; Spira A; Sante publique, epidemiologie, reproduction humaine Hopital de; Bicetre, Le Kremlin-Bicetre.; Epidemiologic trends in sexually transmitted diseases strongly vary in the world. The situation is worrying in the developing countries. Both the incidences and prevalences are very high antibiotic resistance is expanding and interactions between sexually transmitted diseases and human immunodeficiency virus contribut
[Early syphilis]: Rev Prat. 1996 Oct 15;46(16):1948-51. Unique Identifier : AIDSLINE MED/97132749; Morel P; Service de dermatologie 2, Hopital Saint-Louis, Paris.; Given the transmission of Treponema pallidum during human sexual contact, syphilis now occurs in France only in sexually high-risk, disadvantaged populations. The English-language terminology of early syphilis has progressively replaced that of primary and secondary in French
Intrathecal immunoactivation in patients with HIV-1 infection is reduced by zidovudine but not by didanosine.: Scand J Infect Dis. 1996;28(4):329-33. Unique Identifier : AIDSLINE MED/97048557; Hagberg L; Norkrans G; Gisslen M; Wachter H; Fuchs D; Svennerholm B; Department of Infectious Diseases, University of Goteborg, Sweden.; The effect of zidovudine and didanosine on the cerebrospinal fluid (CSF) concentrations of neopterin was studied in 12 patients with human immunodeficiency virus type-1 (HIV-1) infection 3-12 months after initiation of antiretroviral therapy. Ten treatment periods on zidovudine and 7 on didanosine were analysed. The C
Human immunodeficiency virus infection of human bone marrow stromal myoid cells.: Scand J Infect Dis. 1996;28(4):335-40. Unique Identifier : AIDSLINE MED/97048558; Ercoli L; Sarmati L; Parisi SG; Mancino G; De Santis G; Bonanno E; Spagnoli LG; Rocchi G; Andreoni M; Division of Infectious Diseases, Tor Vergata University of Rome,; Italy.; In order to investigate the potential susceptibility of bone marrow stromal myoid cells to human immunodeficiency virus (HIV), a myoid cell population devoid of all other cellular components of marrow environment was isolated from 3 normal adult bone marrow samples. The bone marrow myoid cells were infected with 3 dif
Increased production of nitric oxide correlates with viral load and activation of mononuclear phagocytes in HIV-infected patients.: Scand J Infect Dis. 1996;28(4):341-5. Unique Identifier : AIDSLINE MED/97048559; Groeneveld PH; Kroon FP; Nibbering PH; Bruisten SM; van Swieten P; van Furth R; Department of Infectious Diseases, University Hospital Leiden, The; Netherlands.; The objective of our study was to determine the production of nitric oxide (NO) in patients infected with human immunodeficiency virus (HIV) and its relation to cellular immunity, activation of mononuclear phagocytes and the amount of circulating virus. Therefore, serum nitrate, the stable metabolite of NO, the number
Serum polymerase chain reaction for cytomegalovirus DNA for monitoring ganciclovir treatment in AIDS patients.: Scand J Infect Dis. 1996;28(4):347-51. Unique Identifier : AIDSLINE MED/97048560; Marenzi R; Cinque P; Ceresa D; Racca S; Lillo F; Lazzarin A; Division of Infectious Diseases, Scientific Institute San Raffaele,; Milan, Italy.; The virological response to antiviral treatment of cytomegalovirus ( CMV ) infection in patients with AIDS can be monitored by the identification and quantification of CMV pp65 antigen in blood polymorphonuclear leukocyte cells
Vertical transmission of hepatitis C virus infection.: Scand J Infect Dis. 1996;28(4):353-6. Unique Identifier : AIDSLINE MED/97048561; Fischler B; Lindh G; Lindgren S; Forsgren M; Von Sydow M; Sangfelt P; Alaeus A; Harland L; Enockson E; Nemeth A; Department of Paediatrics, Huddinge Hospital, Sweden.; Vertical transmission of hepatitis C virus (HCV) was studied in 58 infants of 55 mothers (3 sets of twins). HCV RNA analyses by the polymerase chain reaction (PCR) and alanine aminotransferase ALT) were performed on consecutive blood samples from birth to 18 months of age (0, 3, 9 and 18 months). Data on factors possi
Detection of Toxoplasma gondii in immunodeficient subjects by gene amplification: influence of therapeutics.: Scand J Infect Dis. 1996;28(4):383-6. Unique Identifier : AIDSLINE MED/97048567; Foudrinier F; Aubert D; Puygauthier-Toubas D; Rouger C; Beguinot I; Halbout P; Lemaire P; Marx-Chemla C; Pinon JM; Laboratoire de Parasitologie, Hopital Maison Blanche, France.; Polymerase chain reaction (PCR) technology was used to detect Toxoplasma gondii DNA in 253 immunodeficient subjects, 179 of whom were infected with the human immunodeficiency virus (HIV). The incidence of toxoplasmosis was 12.3% (22/179) in the HIV-infected subjects and 2.7% (2/74) in the remainder. The sensitivity of
Antimycobacterial synergism of clarithromycin and rifabutin.: Scand J Infect Dis. 1996;28(4):387-90. Unique Identifier : AIDSLINE MED/97048568; Ghebremichael S; Svenson SB; Kallenius G; Hoffner SE; Swedish Institute for Infectious Disease Control, Karolinska; Institute, Stockholm, Sweden.; Clarithromycin and rifabutin are among the most promising drugs for the therapy of infections caused by Mycobacterium avium or other atypical mycobacteria. Since synergism of combined drugs is important in order to achieve strong antimycobacterial activity, the combined inhibitory effects of antibacterial agents shoul
[Prevalence of transmission of zidovudine-resistant viruses in Switzerland. l'Etude suisse de cohorte VIH]: Schweiz Med Wochenschr. 1996 Oct 26;126(43):1845-8. Unique Identifier : AIDSLINE MED/97073584; Yerly S; Rakik A; Kinloch-de-Loes S; Erb P; Vernazza P; Hirschel B; Perrin L; Laboratoire de virologie, Hopital universitaire, Geneve.; Zidovudine (ZDV) was the most widely used anti-HIV drug between 1987 and 1995, and, as already reported, transmission of ZDV-resistant viruses occurs. Several mutations of the reverse transcriptase gene have been identified; one of them affects the 215 codon and is associated with a high degree of resistance. We have
Profile of CGP 61755: a novel and potent HIV-1 protease inhibitor that shows enhanced anti-HIV activity when combined with other antiretroviral agents in vitro.: Schweiz Med Wochenschr. 1996 Oct 26;126(43):1849-51. Unique Identifier : AIDSLINE MED/97073585; Lazdins JK; Bold G; Capraro HG; Cozens R; Fassler A; Flesch G; Klimkait T; Lang M; Mestan J; Poncioni B; Rosel J; Stover D; Tintelnot-Blomley M; Walker MR; Woods-Cook K; CIBA, Pharma Research, Basel.; CGP 61755 is a novel hydroxyethylene derivative produced by a high yield 10 step chemical synthesis. It is highly specific for HIV-1 protease with an IC50 of 1 nM. The ED90 in MT-2, PBLs and macrophages is infected with laboratory strains of HIV-1 or clinical isolates is 30-100 nM. In chronically infected macrophages
The reluctant man of the year [news]: Science. 1997 Jan 17;275(5298):298. Unique Identifier : AIDSLINE MED/97157299; Cohen J
The media's love affair with AIDS research: hope vs. hype [news] [see comments]: Science. 1997 Jan 17;275(5298):298-9. Unique Identifier : AIDSLINE MED/97157298; Cohen J
Mathematical and computational challenges in population biology and ecosystems science.: Science. 1997 Jan 17;275(5298):334-43. Unique Identifier : AIDSLINE MED/97148483; Levin SA; Grenfell B; Hastings A; Perelson AS; Department of Ecology and Evolutionary Biology, Princeton University,; Princeton, NJ 08544, USA.; Mathematical and computational approaches provide powerful tools in the study of problems in population biology and ecosystems science. The subject has a rich history intertwined with the development of statistics and dynamical systems theory, but recent analytical advances, coupled with the enhanced potential of high
[HIV infection caused by cold preserved bone transplants]: Unfallchirurg. 1996 Sep;99(9):679-84. Unique Identifier : AIDSLINE MED/97080367; Schratt HE; Regel G; Kiesewetter B; Tscherne H; Unfallchirurgische Klinik, Medizinische Hochschule, Hannover.; We reporting four cases of HIV infection caused by bone allografts from one donor. All transplantations were performed between November 1984 and January 1985. In all, 12 recipients had bone allografts from the HIV-infected donor, 7 of whom are now HIV-negative and 4, HIV-positive. One of the patients died a natural de
Vitamin A supplementation and HIV.: S Afr Med J. 1996 Apr;86(4 Suppl):452. Unique Identifier : AIDSLINE MED/97071700
'Broken dreams' [news]: S Afr Med J. 1996 Sep;86(9):1048, 1050. Unique Identifier : AIDSLINE MED/97043691; Jones JS
The Hlabisa-Liverpool HIV link [news]: S Afr Med J. 1996 Sep;86(9):1048, 1050. Unique Identifier : AIDSLINE MED/97043690; Jones JS
Is there a cure for AIDS? [news]: S Afr Med J. 1996 Sep;86(9):1058, 1063. Unique Identifier : AIDSLINE MED/97043694; Karim SS; Karim QA
Coping with the impact of the HIV epidemic--the Hlabisa-Liverpool HIV link [editorial]: S Afr Med J. 1996 Sep;86(9):1077-8. Unique Identifier : AIDSLINE MED/97043700; Gilks CF; Haran D; Wilkinson D
Every person infected with HIV-1 should be in a lifelong early intervention program [editorial]: Sex Transm Dis. 1996 Sep-Oct;23(5):351-2. Unique Identifier : AIDSLINE MED/97039511; Francis DP
Predictors of condom use and human immunodeficiency virus test seeking among women living in inner-city public housing developments.: Sex Transm Dis. 1996 Sep-Oct;23(5):357-65. Unique Identifier : AIDSLINE MED/97039513; Heckman TG; Sikkema KJ; Kelly JA; Fuqua RW; Mercer MB; Hoffmann RG; Winett RA; Anderson ES; Perry MJ; Roffman RA; Solomon LJ; Wagstaff DA; Cargill V; Norman AD; Crumble D; Center for AIDS Intervention Research, Department of Psychiatry and; Behavioral Medicine, Medical College of Wisconsin, Milwaukee 53226,; USA.; BACKGROUND AND OBJECTIVES: To examine prevalence and predictors of condom use and human immunodeficiency virus (HIV) test seeking among women living in inner-city housing developments. STUDY DESIGN: Between April and June 1994, 671 women living in low-income housing developments in five cities in the
Early intervention for human immunodeficiency virus in Baltimore Sexually Transmitted Diseases Clinics. Impact on gonorrhea incidence in patients infected with HIV.: Sex Transm Dis. 1996 Sep-Oct;23(5):370-7. Unique Identifier : AIDSLINE MED/97039515; Golden MR; Rompalo AM; Fantry L; Bein M; Perkins T; Hoover DR; Zenilman JM; School of Medicine, Johns Hopkins University School of Medicine,; Baltimore, Maryland 21205, USA.; BACKGROUND: High incidences of sexually transmitted diseases STD) after posttest counseling have been documented in patients diagnosed with human immunodeficiency virus (HIV) in Baltimore STD clinics. In July 1991, the authors instituted an HIV early intervention program providing long-term medical care and social wor
Finding neurosyphilis without the Venereal Disease Research Laboratory test.: Sex Transm Dis. 1996 Sep-Oct;23(5):392-4. Unique Identifier : AIDSLINE MED/97039518; MacLean S; Luger A; Ludwig Boltzmann Institute of Dermato-Venerological Serodiagnosis,; Vienna-Lainz Hospital, Austria.; BACKGROUND: The cerebrospinal fluid (CSF)-Venereal Disease Research Laboratory (VDRL) test is only 27% sensitive for diagnosing neurosyphilis. Discriminant analysis, used on 124 patients, shows that other commonly used laboratory tests can, in combination, identify 87% of patients with neurosyphilis with 94% specifici
Sexual intercourse during menstruation and self-reported sexually transmitted disease history among women.: Sex Transm Dis. 1996 Sep-Oct;23(5):395-401. Unique Identifier : AIDSLINE MED/97039519; Tanfer K; Aral SO; Centers for Public Health Research and Evaluation, Seattle, Washinton; 98105-0395, USA.; OBJECTIVES: The purpose of this study was to examine the practice of sexual intercourse during menstruation and the relationship of this practice to the experience of sexually transmitted diseases STD) among women in the United States . METHODS: Logistic regression technique was used to
Antibiotic prophylaxis among commercial sex workers in Cebu City, Philippines. Patterns of use and perceptions of efficacy [see comments]: Sex Transm Dis. 1996 Sep-Oct;23(5):407-12. Unique Identifier : AIDSLINE MED/97039521; Abellanosa I; Nichter M; Cebu City STD/AIDS Detection Unit, Philippines.; BACKGROUND: This study describes the extent to which commercial sex workers (CSW) in Cebu City, Philippines perceive prophylactic antibiotic use to be an effective form of prevention for sexually transmitted diseases (STD) and human immunodeficiency virus HIV), as well as the
The causal role for genital ulcer disease as a risk factor for transmission of human immunodeficiency virus. An application of the Bradford Hill criteria.: Sex Transm Dis. 1996 Sep-Oct;23(5):429-40. Unique Identifier : AIDSLINE MED/97039525; Dickerson MC; Johnston J; Delea TE; White A; Andrews E; Epidemiology Department, Glaxo Wellcome, Inc., Research Triangle Park,; North Carolina 27709, USA.; BACKGROUND AND OBJECTIVES: Genital ulcer disease (GUD) has been reported to increase the risk for the acquisition of human immunodeficiency virus (HIV). Although many investigators have reported an increased risk for HIV infection in persons with concurrent or previous GUD, not all studies have been designed to determ
Pulmonary Mycobacterium kansasii infection: comparison of radiological appearances with pulmonary tuberculosis.: Thorax. 1996 Dec;51(12):1243-7. Unique Identifier : AIDSLINE MED/97147751; Evans AJ; Crisp AJ; Hubbard RB; Colville A; Evans SA; Johnston ID; Department of Radiology, University Hospital, Queen's Medical Centre,; Nottingham, UK.; BACKGROUND: A study was undertaken to determine if there are differences in the radiological appearances at presentation between pulmonary infections caused by Mycobacterium kansasii and Mycobacterium tuberculosis. Correct recognition of the organism has important implications with regard to initial therapy and contac
Pulmonary Mycobacterium kansasii infection: comparison of the clinical features, treatment and outcome with pulmonary tuberculosis.: Thorax. 1996 Dec;51(12):1248-52. Unique Identifier : AIDSLINE MED/97147752; Evans SA; Colville A; Evans AJ; Crisp AJ; Johnston ID; Department of Respiratory Medicine, University Hospital, Queen's; Medical Centre, Nottingham, UK.; BACKGROUND: In the United Kingdom Mycobacterium kansasii is the most common pulmonary non-tuberculous mycobacteria to cause disease in the non-HIV positive population. METHODS: The clinical features, treatment, and outcome of 47 patients (13 women) of mean (SD) age 58 (17) years with c
Secretory leukoprotease inhibitor: partnering alpha 1-proteinase inhibitor to combat pulmonary inflammation.: Thorax. 1996 Dec;51(12):1273-4. Unique Identifier : AIDSLINE MED/97147757; Bingle L; Tetley TD; Department of Medicine, Charing Cross and Westminster Medical School,; London, UK.; Secretory leukoprotease inhibitor (SLPI) is a low molecular weight serine proteinase inhibitor, notably of neutrophil elastase (NE), which is synthesised and secreted by the pulmonary epithelium. SLPI plays an important role in limiting NE-induced pulmonary inflammation and, significantly, it also possesses anti-HIV a
Structural and mechanistic relationships between nucleic acid polymerases.: Trends Biochem Sci. 1996 May;21(5):186-90. Unique Identifier : AIDSLINE MED/97025181; Sousa R; Department of Biochemistry, University of Texas Health Sciences; Center, San Antonio, TX, USA.; A superfamily of nucleic acid polymerases that includes the pol I and pol alpha classes of DNA-directed DNA polymerases, mitochondrial and phage DNA-directed RNA polymerases, and most RNA-directed polymerases may be defined on the basis of the occurrence of conserved sequence motifs and tertiary structure similarities
Central and peripheral neurochemical alterations and immune effects of prenatal ethanol exposure in rats.: Int J Dev Neurosci. 1996 Jul;14(4):461-9. Unique Identifier : AIDSLINE MED/97038798; Clausing P; Ali SF; Taylor LD; Newport GD; Rybak S; Paule MG; Division of Neurotoxicology, HFT-132, National Center for; Toxicological Research, Jefferson, AR 72079-9502, USA.; PClausing@FDANT.NCTR.FDA.GOV; In contrast to the well known effects of prenatal ethanol exposure on the central nervous system, data about its peripheral effects are scarce. Here, Sprague Dawley rats were fed a liquid diet (gestational days 0-20) containing 36% ethanol-derived calories (EDCs, group H) or were pair-fed with 18% EDCs (group L) or 0%
Clinico-epidemiological patterns of HIV infection in STD patients in Ibadan.: Afr J Med Med Sci. 1995 Dec;24(4):321-7. Unique Identifier : AIDSLINE MED/97040855; Ekweozor CC; Olaleye OD; Tomori O; Saliu I; Essien EM; Bakare RA; Oni AA; Oyewo OO; Okesola AO; Onyemenem TN; et al; Department of Virology, College of Medicine, University College; Hospital, Ibadan, Nigeria.; The HIV-seropositive subjects identified among the STD Clinic patients seen at a Special Treatment Clinic between 1989 and 1990 were studied to determine the epidemiological and clinical trends of HIV infection in these patients, and to demonstrate any association between the STDs and HIV- seropositivity. Thirty-seven
Thalidomide for treatment of oral aphthous ulcers in patients with human immunodeficiency virus: case report and review.: Am J Gastroenterol. 1997 Jan;92(1):169-70. Unique Identifier : AIDSLINE MED/97149157; Ball SC; Sepkowitz KA; Jacobs JL; Center for Special Studies, New York Hospital-Cornell Medical Center,; New York, USA.
Chronic myeloid leukemia as an immunological target.: Am J Hematol. 1997 Jan;54(1):61-7. Unique Identifier : AIDSLINE MED/97134702; Lim SH; Coleman S; Department of Haematology, University of Wales College of Medicine,; Cardiff, UK.; Various clinical observations have implicated T cells in the control of chronic myeloid leukemia (CML). These observations have in recent years been supported by laboratory results indicating the presence of CML-specific T cells in the lymphocyte repertoire of both normal healthy individuals and disease-bearing patien
Detection of HTLV-I proviral DNA by fluorescence in situ hybridization [letter]: Am J Hematol. 1997 Jan;54(1):86-8. Unique Identifier : AIDSLINE MED/97134710; Uemura Y; Kubota T; Miyagi T; Imamura J; Kubonishi I; Taguchi H; Miyoshi I; Shimizu K
Disparate prognosis of thrombotic microangiopathy in HIV-infected patients with and without AIDS.: Am J Nephrol. 1996;16(5):446-50. Unique Identifier : AIDSLINE MED/97040894; Gadallah MF; el-Shahawy MA; Campese VM; Todd JR; King JW; Department of Medicine, Louisiana State University School of Medicine,; Shreveport 71130, USA.; Thrombotic microangiopathy (TMA) is more common in HIV-infected individuals than in the normal population. In idiopathic TMA, plasmapheresis with or without prednisone decreases the mortality rate from almost 100 to 10%. Patients with HIV-associated TMA, who do not have AIDS, have a similar favorable outcome when trea
Incidence of tuberculosis in the United States among HIV-infected persons. The Pulmonary Complications of HIV Infection Study Group.: Ann Intern Med. 1997 Jan 15;126(2):123-32. Unique Identifier : AIDSLINE MED/97145325; Markowitz N; Hansen NI; Hopewell PC; Glassroth J; Kvale PA; Mangura BT; Wilcosky TC; Wallace JM; Rosen MJ; Reichman LB; Division of Infectious Diseases, Henry Ford Hospital, Detroit, MI; 48202, USA.; BACKGROUND: The resurgence of tuberculosis in the United States is largely linked to the human immunodeficiency virus (HIV) epidemic. Despite this link, the epidemiology of tuberculosis and preventive strategies in patients infected with HIV are not completely understood. OBJECTIVES: T
Human immunodeficiency virus infection and subsequent melanoma.: Ann Plast Surg. 1996 Sep;37(3):273-7. Unique Identifier : AIDSLINE MED/97038108; Kind GM; VonRoenn J; Jansen DA; Bailey MH; Lewis VL Jr; Division of Plastic and Reconstructive Surgery, Davies Medical Center,; San Francisco, CA, USA.; Immunosuppression has been known for many years to be associated with the development of skin cancer, particularly squamous cell carcinoma. The association with melanoma is less clear. This report describes 4 patients with known human immunodeficiency virus (HIV) positivity who subsequently developed malignant melanom
Pyomyositis revisited.: Ann Acad Med Singapore. 1996 Jul;25(4):609-11. Unique Identifier : AIDSLINE MED/97049211; Kong NC; Asmah J; Lim VK; Ong PH; Adam PA; Department of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur,; Malaysia.; Pyomyositis, purportedly a common tropical infection affecting mainly healthy adults and children, appears to be most uncommon in this region. We report a case of pyomyositis caused by a Methicillin-resistant Staphylococcus aureus (MRSA) in a previously healthy army officer. This case serves to illustrate the difficul
Didanosine measurement by radioimmunoassay.: Antimicrob Agents Chemother. 1996 Jun;40(6):1331-4. Unique Identifier : AIDSLINE MED/96338343; DeRemer M; D'Ambrosio R; Morse GD; Department of Pharmacy Practice, State University of New York at; Buffalo, USA.; Didanosine is commonly prescribed as monotherapy or as part of a combination regimen for patients with human immunodeficiency virus infection. The use of lower doses, either as part of a combination regimen or as a result of dose reduction secondary to clinical intolerance, requires that a sensitive assay method be av
Electronic compliance assessment of antifungal prophylaxis for human immunodeficiency virus-infected women.: Antimicrob Agents Chemother. 1996 Jun;40(6):1338-41. Unique Identifier : AIDSLINE MED/96338345; Geletko SM; Segarra M; Mayer KH; Fiore TC; Bettencourt FA; Flanigan TP; Dudley MN; Department of Pharmacy Practice, University of Rhode Island College of; Pharmacy, Kingston 02881-0809, USA.; Several prophylactic medications for opportunistic or recurrent infections are used in human immunodeficiency virus-infected individuals. Essential to the efficacy evaluation of these agents is the accurate reporting of medication compliance. We hypothesized that poor patient compliance with thrice-weekly fluconazole
Comparative resistance of Candida albicans clinical isolates to fluconazole and itraconazole in vitro and in vivo in a murine model.: Antimicrob Agents Chemother. 1996 Jun;40(6):1342-5. Unique Identifier : AIDSLINE MED/96338346; Valentin A; Le Guennec R; Rodriguez E; Reynes J; Mallie M; Bastide JM; Laboratoire d'Immunologie et Parasitologie, UFR Sciences; Pharmaceutiques et Biologiques, Montpellier, France.; Relationships between azole susceptibility and in vivo response to antifungal therapy in a murine model of candidiasis were investigated for Candida albicans isolates sampled from human immunodeficiency virus type 1-positive patients with oropharyngeal candidiasis. The susceptibilities of seven clinical isolates and t
Evaluation of reverse transcriptase and protease inhibitors in two-drug combinations against human immunodeficiency virus replication.: Antimicrob Agents Chemother. 1996 Jun;40(6):1346-51. Unique Identifier : AIDSLINE MED/96338347; Deminie CA; Bechtold CM; Stock D; Alam M; Djang F; Balch AH; Chou TC; Prichard M; Colonno RJ; Lin PF; Virology Department, Bristol-Myers Squibb Pharmaceutical Research; Institute, Wallingford, Connecticut 06492-7660, USA.; Current treatments for human immunodeficiency virus (HIV) include both reverse transcriptase and protease inhibitors . Results from in vitro and clinical studies suggest that combination therapy can be more effective
Pyrimethamine pharmacokinetics in human immunodeficiency virus-positive patients seropositive for Toxoplasma gondii.: Antimicrob Agents Chemother. 1996 Jun;40(6):1360-5. Unique Identifier : AIDSLINE MED/96338349; Jacobson JM; Davidian M; Rainey PM; Hafner R; Raasch RH; Luft BJ; Department of Medicine, Veterans' Affairs Medical Center, Bronx, NY; 10468, USA.; Pyrimethamine pharmacokinetics were studied in 11 human immunodeficiency virus (HIV)-positive patients who were seropositive for exposure to Toxoplasma gondii and were taking zidovudine (AIDS Clinical Trials Group Protocol 102). Pyrimethamine was administered at 50 mg daily for 3 weeks to achieve steady state, and pha
Lack of effect of concomitant zidovudine on rifabutin kinetics in patients with AIDS-related complex.: Antimicrob Agents Chemother. 1996 Jun;40(6):1397-402. Unique Identifier : AIDSLINE MED/96338356; Li RC; Nightingale S; Lewis RC; Colborn DC; Narang PK; Department of Clinical Pharmacology/PK, Pharmacia & Upjohn, Inc.,; Columbus, Ohio 43216, USA.; The effect of concomitant dosing with the antiretroviral agent zidovudine (ZDV) on the pharmacokinetics of rifabutin (RBT) was investigated under steady-state conditions. Sixteen human immunodeficiency virus-positive patients with AIDS-related complex who had been maintained on stable ZDV therapy for > or = 6 weeks we
Identification of novel thiocarboxanilide derivatives that suppress a variety of drug-resistant mutant human immunodeficiency virus type 1 strains at a potency similar to that for wild-type virus.: Antimicrob Agents Chemother. 1996 Jun;40(6):1454-66. Unique Identifier : AIDSLINE MED/96338367; Balzarini J; Brouwer WG; Dao DC; Osika EM; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit Leuven,; Belgium.; A large variety of carboxanilide and thiocarboxanilide derivatives in which the original oxathiin or aliphatic moieties present in the prototype compounds UC84 and UC38 were replaced by an (un) substituted furanyl, thienyl, phenyl, or pyrrole entity have been evaluated for activity against wild-type human immunodefici
Efficiency of nanoparticles as a carrier system for antiviral agents in human immunodeficiency virus-infected human monocytes/macrophages in vitro.: Antimicrob Agents Chemother. 1996 Jun;40(6):1467-71. Unique Identifier : AIDSLINE MED/96338368; Bender AR; von Briesen H; Kreuter J; Duncan IB; Rubsamen-Waigmann H; Chemotherapeutical Research Institute Georg-Speyer-Haus, Frankfurt am; Main, Germany.; Polyhexylcyanoacrylate nanoparticles loaded with either the human immunodeficiency virus (HIV) protease inhibitor saquinavir (Ro 31-8959) or the nucleoside analog zalcitabine 2 ,3 -dideoxycytidine) were prepared by emulsion polymerization and tested for antiviral activity in primary human monocytes/macrophages in vitr
Radioimmunoassay for quantitation of 2',3'-didehydro-3'-deoxythymidine (D4T) in human plasma.: Antimicrob Agents Chemother. 1996 Jun;40(6):1472-5. Unique Identifier : AIDSLINE MED/96338369; Zhou XJ; Chakboub H; Ferrua B; Moravek J; Guedj R; Sommadossi JP; Department of Pharmacology, University of Alabama at Birmingham; 35294-0019, USA.; 2 ,3 -Didehydro-3 -deoxythymidine (D4T, or stavudine ) has been recently approved for the treatment of AIDS. In the present study, a specific and sensitive radioimmunoassay (RIA) was developed for the quantitation of D4T in human plasma. The RIA is a d
Human serum alpha 1 acid glycoprotein reduces uptake, intracellular concentration, and antiviral activity of A-80987, an inhibitor of the human immunodeficiency virus type 1 protease.: Antimicrob Agents Chemother. 1996 Jun;40(6):1491-7. Unique Identifier : AIDSLINE MED/96338373; Bilello JA; Bilello PA; Stellrecht K; Leonard J; Norbeck DW; Kempf DJ; Robins T; Drusano GL; Department of Medicine, Albany Medical College, New York 12208, USA.; The therapeutic utility of a human immunodeficiency virus type 1 HIV-1) protease inhibitor may depend on its intracellular concentration, which is a property of its uptake, metabolism, and/or efflux. Previous studies in our laboratory indicated that the addition of alpha 1 acid glycoprotein (alpha 1 AGP) to the medium
Pharmacokinetics of lamivudine in human immunodeficiency virus-infected patients with renal dysfunction.: Antimicrob Agents Chemother. 1996 Jun;40(6):1514-9. Unique Identifier : AIDSLINE MED/96338377; Heald AE; Hsyu PH; Yuen GJ; Robinson P; Mydlow P; Bartlett JA; Department of Medicine, Duke University Medical Center, Durham, North; Carolina 27710, USA.; The purpose of this study was to determine the safety and pharmacokinetics of lamivudine ( 3TC ), a nucleoside analog that has shown potent in vitro and recent in vivo activity against human immunodeficiency virus. Sixteen human immunodeficiency virus-i
Bioluminescence screening in vitro (Bio-Siv) assays for high-volume antimycobacterial drug discovery.: Antimicrob Agents Chemother. 1996 Jun;40(6):1536-41. Unique Identifier : AIDSLINE MED/96338382; Arain TM; Resconi AE; Hickey MJ; Stover CK; Department of Molecular Microbiology, PathoGenesis Corporation,; Seattle, Washington 98119, USA. tarain@path.path.com; Bioluminescence-based assays to indicate antimicrobial susceptibility have been developed and validated for recombinant strains of Mycobacterium tuberculosis, Mycobacterium bovis BCG, Mycobacterium avium, and Mycobacterium intracellulare expressing an integrated eukaryotic luciferase gene. MICs determined with these b
Zidovudine does not affect transplacental transfer or systemic clearance of stavudine (2',3'-didehydro-3'-deoxythymidine) in the pigtailed macaque (Macaca nemestrina).: Antimicrob Agents Chemother. 1996 Jun;40(6):1569-71. Unique Identifier : AIDSLINE MED/96338391; Odinecs A; Nosbisch C; Unadkat JD; Department of Pharmaceutics, University of Washington, Seattle 98195,; USA.; Stavudine (22 micrograms/min/kg of body weight) was infused alone via the femoral vein) or simultaneously with zidovudine (66 micrograms/min/kg) to three near-term pregnant macaques. No significant differences were found between the mean steady-state
Fluconazole as prophylaxis against fungal infection in patients with advanced HIV infection.: Arch Intern Med. 1997 Jan 13;157(1):64-9. Unique Identifier : AIDSLINE MED/97149234; Manfredi R; Mastroianni A; Coronado OV; Chiodo F; Department of Clinical and Experimental Medicine, University of; Bologna, Italy.; BACKGROUND: There is limited information regarding the usefulness of primary antifungal prophylaxis in patients with advanced human immunodeficiency virus (HIV) disease. OBJECTIVE: To evaluate the efficacy and safety of oral fluconazole treatment for the prevention of systemic fungal diseases related to the acquired i
[Morphologic characteristics of epidermal cells in HIV infection]: Arkh Patol. 1996 Sep-Oct;58(5):64-7. Unique Identifier : AIDSLINE MED/97113667; Barkhina TG; Parkhomenko IuG; Skin biopsies at the plaque regions and adjacent skin obtained from HIV-infected 22-40-year-old patients with Kaposi s sarcoma have been analyzed. Morphological changes revealed depended on the stage of the disease and cell specificity. The alterations were as follows: cell adenoma with degeneration and destruction of
[Quantification of feline immunodeficiency virus (FIV) RNA in the plasma of infected cats]: Berl Munch Tierarztl Wochenschr. 1996 Aug;109(8):265-9. Unique Identifier : AIDSLINE MED/96387070; Vahlenkamp TW; De Ronde A; Horzinek MC; Egberink HF; Abteilung Virologie, Fachgruppe Infektionskrankheiten und Immunologie,; Veterinarmedizinische Fakultat, Universitat Utrecht Niederlande.; A competitive reverse transcription-polymerase chain reaction RT-PCR) was used to quantify RNA of feline immunodeficiency virus (FIV) in cats. The assay uses in vitro synthesized RNA as a competitive internal control. The synthesized RNA has a 22-base deletion with respect to the wild-type sequence. PCR products were
Bile pigments as HIV-1 protease inhibitors and their effects on HIV-1 viral maturation and infectivity in vitro.: Biochem J. 1996 Dec 1;320 ( Pt 2):681-6. Unique Identifier : AIDSLINE MED/97129044; McPhee F; Caldera PS; Bemis GW; McDonagh AF; Kuntz ID; Craik CS; Department of Pharmaceutical Chemistry, University of California, San; Francisco, USA.; Using recently developed molecular-shape description algorithms, we searched the Available Chemical Directory for known compounds similar in shape to the potent HIV-1 protease inhibitor Merck L-700,417; 15 compounds most similar in shape to the inhibitor were selected for testing in vitro. Four of these inhibited the
HIV-1 LTR activity in human CD40-activated B lymphocytes is dependent on NF-kappaB.: Biochem Biophys Res Commun. 1996 Dec 24;229(3):959-64. Unique Identifier : AIDSLINE MED/97115684; Lapointe R; Lemieux R; Darveau A; Canadian Red Cross Society, Transfusion Centre of Quebec, G1V 4M3,; Canada. adarveau@rsvs.ulaval.ca; CD40-stimulated human B lymphocytes are highly permissive to a productive infection by the human immunodeficiency virus type 1. In these cells, nuclear factors involved in activation of the HIV-1 LTR, which contains the transcriptional control elements of the virus, are unknown. Transient expression assays with plasmi
Cervicovaginal anti-HIV antibodies in index women from HIV-discordant, exclusively heterosexual, couples.: Viral Immunol. 1996;9(3):155-8. Unique Identifier : AIDSLINE MED/97045423; Belec L; Prazuck T; Payan C; Mohamed AS; Cancre N; Hocini H; Malkin JE; Pillot J; Laboratoire de Virologie, Centre Hospitalo-Universitaire (CHU); Broussais, Paris, France.; Cervicovaginal IgA and IgG anti-gp160 antibodies were evaluated in cervicovaginal secretions from twelve HIV-discordant heterosexual couples, matched with twelve HIV-concordant heterosexual couples, at similar stage of HIV disease. The mean reciprocal end-point titers of cervicovaginal IgA or IgG to gp160 were similar
Recombinant human immunodeficiency virus type 1 (HIV-1) Tat protein inhibits phagolysosomal fusion in human peripheral blood monocytes.: Viral Immunol. 1996;9(3):169-74. Unique Identifier : AIDSLINE MED/97045425; Pittis MG; Prada F; Sternik G; Sen L; Laboratorio de Biologia Celular y Retrovirus, Hospital de Pediatria; Juan P. Garrahan, Buenos Aires, Argentina.; The effect of recombinant HIV-1 Tat protein on different functions of peripheral blood monocytes, such as candidacidal activity and phagolysosomal fusion, was evaluated. HIV-1 Tat protein caused a significant impairment of phagolysosomal fusion at 100 ng/ml (p = 0.018). The inhibitory effect of Tat on phagolysosomal f
Analysis of neutralizing and enhancing antibodies to human immunodeficiency virus type 1 primary isolates in plasma of individuals infected with env Genetic subtype B and E viruses in Thailand.: Viral Immunol. 1996;9(3):175-85. Unique Identifier : AIDSLINE MED/97045426; Auewarakul P; Louisirirotchanakul S; Sutthent R; Taechowisan T; Kanoksinsombat C; Wasi C; WHO Collaborating Centre on AIDS, Department of Microbiology, Faculty; of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.; Twenty-seven HIV-1 isolates were obtained from 51 asymptomatic HIV-1-infected pregnant women or intravenous drug users (IDUs) in Bangkok. Using heteroduplex mobility assay (HMA), it was found that the majority of the HIV-1 isolates (9 out of 11) from pregnant women belonged to genetic subtype E, whereas most of the su
Chemokine receptors and HIV resistance: the story so far.: Immunol Today. 1996 Oct;17(10):447. Unique Identifier : AIDSLINE MED/97065258
Improvements in live-attenuated HIV vaccines?: Immunol Today. 1996 Sep;17(9):401. Unique Identifier : AIDSLINE MED/97007278
CD4: CD8 ratio and HIV infection: the "tap-and-drain' hypothesis.: Immunol Today. 1996 Sep;17(9):414-7. Unique Identifier : AIDSLINE MED/97007283; Amadori A; Zamarchi R; Chieco-Bianchi L; Institute of Oncology, University of Padova, Italy.; cor01@ipdunidx.unipd.it
Tissue-specific migration of lymphocytes: a key role for Th1 and Th2 cells?: Immunol Today. 1996 Sep;17(9):421-4. Unique Identifier : AIDSLINE MED/97007285; Meeusen EN; Premier RR; Brandon MR; Centre for Animal Biotechnology, School of Veterinary Science,; University of Melbourne, Parkville, Victoria, Australia.; els@rubens.its.unimelb.edu.au
HIV-1-related mechanisms of suppression of CD34+ hematopoietic progenitors.: Pathobiology. 1996;64(1):53-8. Unique Identifier : AIDSLINE MED/97009692; Zauli G; Capitani S; Institute of Human Anatomy, University of Ferrara, Italy.; Peripheral blood cytopenias and bone marrow abnormalities are frequently observed in HIV-1-seropositive subjects. Two major mechanisms have been proposed to explain the hematopoietic failure often observed in patients with advanced HIV-1 disease: i) infection of cells composing the bone marrow microenvironment with a
Transplantation of systemic sclerosis (SSc) skin grafts into severe combined immunodeficient mice: increased presence of SSc leukocytes in SSc skin grafts and autoantibody production following autologous leukocyte transfer.: Pathobiology. 1996;64(2):99-114. Unique Identifier : AIDSLINE MED/97043077; Kraling BM; Juhasz I; Freundlich B; Maul GG; Jimenez SA; Department of Medicine, Jefferson Medical College, Thomas Jefferson; University, Philadelphia, PA 19107-5541, USA.; This study was performed to evaluate the potential of the severe combined immunodeficient (Scid) mouse as a model to study the pathogenesis of systemic sclerosis (SSc). Scid mice were divided into three treatment groups: group 1 received skin grafts and autologous peripheral blood mononuclear cells (PBMC) from either
[Guidelines for the prevention of opportunistic infections in persons with HIV or AIDS in Latin America and the Caribbean. USPHS/IDSA]: Bol Oficina Sanit Panam. 1996 Nov;121(5):377-415. Unique Identifier : AIDSLINE MED/97130252
Type 1 and type 2: a fundamental dichotomy for all T-cell subsets.: Curr Opin Immunol. 1996 Jun;8(3):336-42. Unique Identifier : AIDSLINE MED/96415585; Carter LL; Dutton RW; Trudeau Institute, Saranac Lake, NY 12983, USA. carter@northnet.org; Cytokine secretion is not confined to CD4+ T cells; rather, Type 1 and Type 2 populations of CD8+ and gamma delta T cells can also be generated in vitro and isolated from in vivo situations. These subsets and their physiological functions are significant.
Magnesium-mediated reversal of the apparent virucidal effect of ascorbic acid or congo red reacted in vitro with the human immunodeficiency virus.: Biologicals. 1996 Jun;24(2):113-6. Unique Identifier : AIDSLINE MED/97043986; Rawal BD; Vyas GN; Department of Laboratory Medicine, University of California, San; Francisco 94143-0134, USA.; The mechanism of in vitro inactivation of cell-free human immunodeficiency virus (CFHIV) with ascorbic acid (M) or Congo red (CR) was investigated with specific regard to the impact of an excess of magnesium ions on the viral inactivation. Quadruplicate reaction mixtures containing CFHIV were mixed with a virus-inacti
Improvement of virus safety of a S/D-treated factor VIII concentrate by additional dry heat treatment at 100 degrees C.: Biologicals. 1996 Jun;24(2):125-30. Unique Identifier : AIDSLINE MED/97043988; Dichtelmuller H; Rudnick D; Breuer B; Kotitschke R; Kloft M; Darling A; Watson E; Flehmig B; Lawson S; Frosner G; Biotest Pharma GmbH, Dreieich, Germany.; In order to increase the virus safety of a solvent/detergent-treated Factor VIII concentrate in regard to non-lipid coated viruses and to respond to the continuous discussion about reports on hepatitis A transmission by Factor VIII preparations, we have investigated the effect of a terminal dry heat treatment (30 min
Adoptively transferred late allergic airway responses are associated with Th2-type cytokines in the rat.: Am J Respir Cell Mol Biol. 1997 Jan;16(1):69-74. Unique Identifier : AIDSLINE MED/97152149; Watanabe A; Mishima H; Kotsimbos TC; Hojo M; Renzi PM; Martin JG; Hamid QA; Meakins-Christie Laboratories, McGill University, Montreal, Quebec,; Canada.; Late allergic airway responses can be transferred by CD4+ T cells in the rat. To investigate the role of T-cell cytokines in these responses, we examined the expression of mRNA for Th2 interleukin [IL]-4 and IL-5) and Th1 ( IL-2 and interferon gamma [INF-gamma])-type cy
Sexual violence against women living with or at risk for HIV infection.: Am J Prev Med. 1996 Sep-Oct;12(5):304-10. Unique Identifier : AIDSLINE MED/97066156; Zierler S; Witbeck B; Mayer K; Department of Community Health, Brown University, Providence, RI; 02912, USA.; OBJECTIVES: This study investigates factors associated with sexual violence against adult women living with and at risk for HIV infection. METHODS: Women at least 18 years old and living in Rhode Island or southeast Massachusetts enrolled from 1987 to 1992 in a cohort study of heterosexual HIV risk. A total of 408 wom
Prevalence of human immunodeficiency virus in the trauma emergency room.: Arch Orthop Trauma Surg. 1996;115(6):337-8. Unique Identifier : AIDSLINE MED/97061062; Froschle G; Uner AB; Wening JV; Department of Trauma Surgery, University Hospital Eppendorf,; University of Hamburg, Germany.; Over 55,000 human immunodeficiency virus (HIV)-infections had been reported to the German Federal Health Council as of December 1992. More than 60% of a total of over 9000 overt AIDS cases has arisen in the five largest urban areas. Patients with open wounds represent a daily risk of contamination for emergency room p
Validity of random urines to quantitate proteinuria in children with human immunodeficiency virus nephropathy.: Pediatr Nephrol. 1996 Oct;10(5):598-601. Unique Identifier : AIDSLINE MED/97052935; Abitbol CL; Strauss J; Zilleruelo G; Montane B; Rodriguez E; Department of Pediatrics, University of Miami/Jackson Memorial Medical; Center, Florida 33101, USA.; Accurate assessment of proteinuria in pediatric patients infected with the human immunodeficiency virus (HIV) is limited by constraints imposed by timed urine collections and low creatinine excretion in very ill patients with low muscle mass. We therefore sought to validate the use of random urine specimens to quantit
Role of cysteine and glutathione in HIV infection and cancer cachexia: therapeutic intervention with N-acetylcysteine.: Adv Pharmacol. 1997;38:581-600. Unique Identifier : AIDSLINE MED/97051086; Droge W; Gross A; Hack V; Kinscherf R; Schykowski M; Bockstette M; Mihm S; Galter D; Division of Immunochemistry, Deutsches Krebsforschungszentrum,; Heidelberg, Germany.
AIDS-related bone marrow lesions--myelodysplastic features or predominant inflammatory-reactive changes (HIV-myelopathy)? A comparative morphometric study by immunohistochemistry with special emphasis on apoptosis and PCNA-labeling.: Anal Cell Pathol. 1996 Aug;11(3):141-57. Unique Identifier : AIDSLINE MED/97043880; Thiele J; Zirbes TK; Bertsch HP; Titius BR; Lorenzen J; Fischer R; Institute of Pathology, University of Cologne, FRG.; There seems to be general agreement that AIDS-related bone marrow changes are consistent with myelodysplastic features. To re-evaluate this assumption more critically, a comparative study was performed on marrow smears and trephine biopsies in 20 patients presenting manifest stages of AIDS and in 30 patients with prime
Local immune response in endometrial carcinomas.: Br J Obstet Gynaecol. 1997 Jan;104(1):110-4. Unique Identifier : AIDSLINE MED/97142686; Hachisuga T; Fukuda K; Nakamura S; Iwasaka T; Sugimori H; Department of Obstetrics and Gynaecology, School of Medicine, Fukuoka; University, Japan.; OBJECTIVE: To determine whether Langerhans cells act as antigen-presenting cells in endometrial carcinomas and their related lesions. SAMPLES: Frozen endometrial samples were obtained from 13 women with normal menstrual cycles, 3 postmenopausal women, 11 women with hyperplasia (simple 4, complex 4 and atypical 3) and e
Zn2+ promotes the self-association of human immunodeficiency virus type-1 integrase in vitro.: Biochemistry. 1997 Jan 7;36(1):173-80. Unique Identifier : AIDSLINE MED/97146475; Lee SP; Xiao J; Knutson JR; Lewis MS; Han MK; Department of Biochemistry and Molecular Biology, Georgetown; University Medical Center, Washington, DC 20007, USA.; It has been recently demonstrated that the Mg(2+)-dependent 3 -processing activity of purified human immunodeficiency virus type-1 (HIV-1) integrase is stimulated by the addition of exogenous Zn2+ [Lee, S. P., & Han, M. K. (1996) Biochemistry 35, 3837-3844]. This activation was hypothesized to result from integrase
Nurses take the lead in HIV/AIDS care.: Tenn Nurse. 1996 Oct;59(5):11, 13. Unique Identifier : AIDSLINE MED/97158918; Reid J; Comprehensive Care Center, Nashville, Tennessee 37204, USA.
A journey of parenting a child with HIV.: Tenn Nurse. 1996 Oct;59(5):14-5. Unique Identifier : AIDSLINE MED/97158919
Living with open hearts.: Tenn Nurse. 1996 Oct;59(5):16-7. Unique Identifier : AIDSLINE MED/97158920; Marquart S; Middle Tennessee State University School of Nursing, USA.
HIV infected RN launches national campaign for safer needle technologies [interview]: Tenn Nurse. 1996 Oct;59(5):17, 34. Unique Identifier : AIDSLINE MED/97158921; Arnold L
Resources for HIV and AIDS services or information.: Tenn Nurse. 1996 Oct;59(5):35. Unique Identifier : AIDSLINE MED/97158922
[Coinfection by mycobacteria in HIV-positive patients]: Enferm Infecc Microbiol Clin. 1996 Oct;14(8):466-9. Unique Identifier : AIDSLINE MED/97108301; von Wichmann MA; Rodriguez-Arrondo F; Iribarren JA; Arrizabalaga J; Idigoras P; Barandiaran F; Unidad de Enfermedades Infecciosas, Hospital Nuestra Senora de; Aranzazu, Alto de Zorroaga, San Sebastian.; BACKGROUND: The aim of this study was to describe the clinical characteristics and therapeutic management of coinfection by mycobacteria in the authors hospital. METHODS: Two cases of coinfection detected in mixed cultures in agar 7H11 or simultaneous positive cultures in several evaluable clinical samples (blood cult
[Microbiological study of some microorganisms implicated in sexually transmitted diseases among the female prison population]: Enferm Infecc Microbiol Clin. 1996 Oct;14(8):474-8. Unique Identifier : AIDSLINE MED/97108303; Alonso-Sanz M; Chaves F; Sanchez S; Romero N; Dronda F; Unidad de Enfermedades Infecciosas-Microbiologia, Hospital General; Penitenciario.; BACKGROUND: Sexually transmitted diseases (STD) are of over greater interest, particularly since the appearance of the human immunodeficiency virus ( HIV) in the last decade. Asymptomatic or oligosymptomatic infections are very frequent, overall in women. The aim of this study was to know the prevalence of certain STD
[Persistent fever, retroperitoneal adenopathies, pancytopenia, and hepatosplenomegaly in an African immigrant with HIV-1 infection]: Enferm Infecc Microbiol Clin. 1996 Oct;14(8):499-500. Unique Identifier : AIDSLINE MED/97108308; Llibre JM; Salvador A; Casanova J; Galles C; Servicio de Medicina Interna, Hospital Sant Jaume, Calella, Barcelona.
[Pneumonia caused by Pneumocystis carinii in a drug addict without evidence of HIV infection (letter)]: Enferm Infecc Microbiol Clin. 1996 Oct;14(8):505. Unique Identifier : AIDSLINE MED/97108311; Calderon E; Medrano FJ; Cano S; Varela JM
[Infectious endocarditis caused by Escherichi coli (letter)]: Enferm Infecc Microbiol Clin. 1996 Oct;14(8):509-10. Unique Identifier : AIDSLINE MED/97108316; Valencia ME; Guinea J; Enriquez A; Gonzalez-Lahoz J
Ocular toxoplasmosis in HIV infection [editorial]: Int J STD AIDS. 1996 Aug-Sep;7(5):307-9. Unique Identifier : AIDSLINE MED/97050089; Rodgers CA; Harris JR; Toxoplasmosis accounts for 1-3% of ocular infections in patients with AIDS1. There are a variety of clinical manifestations that can be confused with other ocular disease. It may be the first manifestations of intracranial and disseminated Toxoplasma gondii infection. Prompt recognition and early treatment with antipa
The radiological manifestations of the acquired immunodeficiency syndrome: Part 2.: Int J STD AIDS. 1996 Aug-Sep;7(5):310-4. Unique Identifier : AIDSLINE MED/97050090; Banerjee AK; Birmingham Heartlands Hospital, UK.
Pelvic inflammatory disease.: Int J STD AIDS. 1996 Aug-Sep;7(5):315-21. Unique Identifier : AIDSLINE MED/97050091; Mann SN; Smith JR; Barton SE; Department of Genito-urinary Medicine, St Stephen's Centre, London,; UK.
Respiratory grey case.: Int J STD AIDS. 1996 Aug-Sep;7(5):322. Unique Identifier : AIDSLINE MED/97050092; Seemungal B; Klein JL; St Mary's Hospital, London, UK.
STD care in Zambia: an evaluation of the guidelines for case management through a syndromic approach.: Int J STD AIDS. 1996 Aug-Sep;7(5):324-32. Unique Identifier : AIDSLINE MED/97050093; Hanson S; Sunkutu RM; Kamanga J; Hojer B; Sandstrom E; Department of International Health and Social Medicine, Karolinska; Institutet, Stockholm, Sweden.; Clinical diagnosis of STDs is unreliable and therefore constitutes a poor basis for choice of treatment. A syndromic approach has been suggested to increase effectiveness of treatment in resource poor settings. Algorithms for the treatment of STD syndromes were evaluated. A total of 436 patients were followed; cure ra
Human papillomavirus deoxyribonucleic acid in cervix only detected in girls after coitus.: Int J STD AIDS. 1996 Aug-Sep;7(5):333-6. Unique Identifier : AIDSLINE MED/97050094; Andersson-Ellstrom A; Hagmar BM; Johansson B; Kalantari M; Warleby B; Forssman L; Centre for Public Health Research, Karlstad, Sweden.; In a prospective cohort study on the prevalence of HPV in a group of female Swedish students, we obtained repeated cytological specimens during a period of 2 years, for cytological diagnosis and PCR detection of HPV. The group comprised 98 girls, sampled between 15 and 17 years, and 82 of them completed the study. The
Differentiation of central nervous system lesions in AIDS patients using positron emission tomography (PET).: Int J STD AIDS. 1996 Aug-Sep;7(5):337-46. Unique Identifier : AIDSLINE MED/97050095; Heald AE; Hoffman JM; Bartlett JA; Waskin HA; Department of Medicine, Duke University Medical Center, Durham, NC; 27710, USA.; To determine if positron emission tomography (PET) imaging using F-18 fluorodeoxyglucose (FDG) can accurately distinguish between malignant and infectious central nervous system (CNS) mass lesions in patients with human immunodeficiency virus (HIV) infection, a prospective case series of 18 patients with HIV infection
Audits of the treatment of genital warts: closing the feedback loop.: Int J STD AIDS. 1996 Aug-Sep;7(5):347-52. Unique Identifier : AIDSLINE MED/97050096; Reynolds M; Fraser PA; Lacey CJ; Department of Genitourinary Medicine, Leeds General Infirmary, UK.; An initial audit of the treatment of patients presenting to the GUM Department at Leeds General Infirmary with a first episode of anogenital warts was reported in 1993. Treatment was found to be unselective and poorly monitored and the results of treatment were disappointing. As a consequence, guidelines for the manag
University students' knowledge of STDs: labels, symptoms and transmission.: Int J STD AIDS. 1996 Aug-Sep;7(5):353-8. Unique Identifier : AIDSLINE MED/97050097; Minichiello V; Paxton S; Cowling V; Cross G; Savage J; Sculthorpe A; Cairns B; Department of Health Studies, University of New England, Australia.; A sample of 630 Victorian university students, aged between 17 and 24, completed a questionnaire on knowledge of sexually transmitted diseases (STDs). Overall students demonstrated moderate levels of knowledge about the names of diseases which are transmitted by sexual contact, symptoms and medical facts and transmiss
Characterizing patients with multiple sexually acquired infections: a multivariate analysis.: Int J STD AIDS. 1996 Aug-Sep;7(5):359-61. Unique Identifier : AIDSLINE MED/97050098; Pakianathan MR; Ross JD; McMillan A; Department of GUM, Royal Infirmary of Edinburgh, UK.; It has long been recognized that sexually transmitted diseases STDs) may occur concurrently hence necessitating screening in individuals attending Genito-Urinary Medicine (GUM) clinics. However there are few data on individuals with more than one concurrent STD. Individuals attending the GUM Department in the Royal In
Forty years on--contact tracing in Wakefield.: Int J STD AIDS. 1996 Aug-Sep;7(5):362-4. Unique Identifier : AIDSLINE MED/97050099; King D; Chown R; Clarke J; Department of GUM, Clayton Hospital, Wakefield, UK.; An audit of contact tracing activity for a range of common sexually transmitted diseases (STD) was performed prospectively on 100 consecutive referrals to the health advisers at the Genitourinary Medicine (GUM) clinic in Wakefield. Targets for contact attendance were set according to the initial index patient diagnosi
Prevalence of HIV-1, HIV-2 and HTLV antibody, in Fortaleza, Ceara, Brazil, 1993-1994.: Int J STD AIDS. 1996 Aug-Sep;7(5):365-9. Unique Identifier : AIDSLINE MED/97050100; Broutet N; de Queiroz Sousa A; Basilio FP; Sa HL; Simon F; Dabis F; INSERM U. 330, Universite de Bordeaux II, France.; To evaluate the respective part of HIV-1, HIV-2, and human T lymphotropic virus (HTLV) infection in Fortaleza, the principal city of the Ceara state (Northeast of Brazil ), a cross-sectional seroepidemiological survey was conducted from July 1993 to February 1994 in 6 selected group
Drug-induced oesophageal ulceration in a patient with acquired immunodeficiency syndrome.: Int J STD AIDS. 1996 Aug-Sep;7(5):370-1. Unique Identifier : AIDSLINE MED/97050101; Craig JM; Giaffer MH; Talbot MD; Department of GUM, Royal Hallamshire Hospital, Sheffield, UK.
Are we preventing Pneumocystis carinii pneumonia in regular clinic attenders with HIV.: Int J STD AIDS. 1996 Aug-Sep;7(5):372. Unique Identifier : AIDSLINE MED/97050102; Richardson C; Fadojutimi M; Bunting P; Welch J; Department of GUM, King's Healthcare, London, UK.
Central venous catheter infections in AIDS patients with cytomegalovirus.: Int J STD AIDS. 1996 Aug-Sep;7(5):372-3. Unique Identifier : AIDSLINE MED/97050103; Ustianowski AP; Nandwani R; Turton CW; General Hospital, Hove, London, UK.
Efficacy of anti-chlamydial therapy with oxytetracycline and erythromycin.: Int J STD AIDS. 1996 Aug-Sep;7(5):373-4. Unique Identifier : AIDSLINE MED/97050104; Ross JD; Crean A; McMillan A; Department of Genitourinary Medicine, Edinburgh Royal Infirmary, UK.
Non-consultant career grade staff in GUM: a reliable silent backbone of the specialty or, a spare pair of hands?: Int J STD AIDS. 1996 Aug-Sep;7(5):375-7. Unique Identifier : AIDSLINE MED/97050105; Hiscock T; Streetly Rd Surgery, Erdington, Birmingham, UK.; Much of the genito-urinary medicine (GUM) medical workforce of the UK is composed of non-consultant career grade doctors (NCCG) whose lot in the specialty has been much neglected. A questionnaire was sent to the 108 known members of 1994 and a resume of their replies is presented. The greatest plight of this group apa
Perinatal transmission of parturient syphilis in Mozambique [letter]: Int J STD AIDS. 1996 Aug-Sep;7(5):378-9. Unique Identifier : AIDSLINE MED/97050106; Lindstrand A; Bergstrom S; Bugalho A; Helgesson AM; Hederstedt B
Lack of AIDS awareness in primary care physicians: another Third World disaster? [letter]: Int J STD AIDS. 1996 Aug-Sep;7(5):379-80. Unique Identifier : AIDSLINE MED/97050107; Bambery P; Jindal HV; Kumar B
Day case insertion of Hickman lines in HIV positive patients in a radiological unit [letter]: Int J STD AIDS. 1996 Aug-Sep;7(5):380-2. Unique Identifier : AIDSLINE MED/97050108; Bergin CJ; Wallis F; O'Leary A; O'Reilly M; Molloy M; Mulcahy F
Intrapenile drug delivery systems.: Int J STD AIDS. 1996;7 Suppl 3:13-5. Unique Identifier : AIDSLINE MED/97030433; Brindley GS
Oral treatments for erectile dysfunction.: Int J STD AIDS. 1996;7 Suppl 3:16-8. Unique Identifier : AIDSLINE MED/97030434; Riley A; Human Sexuality Unit, St George's Hospital Medical School, London, UK.
Surgical management of erectile dysfunction.: Int J STD AIDS. 1996;7 Suppl 3:19-21. Unique Identifier : AIDSLINE MED/97030435; Witherow R; St Mary's Hospital, London, UK.
Clinical aspects of erectile dysfunction.: Int J STD AIDS. 1996;7 Suppl 3:2-4. Unique Identifier : AIDSLINE MED/97030430; Dinsmore WW; Genito-Urinary Medicine Department, Royal Victoria Hospital, Belfast,; UK.
Financial implications of an erectile dysfunction clinic in a Trust hospital.: Int J STD AIDS. 1996;7 Suppl 3:22-3. Unique Identifier : AIDSLINE MED/97030436; Harris JR; St Mary's Hospital, London, UK.
The treatment of patients with diabetes.: Int J STD AIDS. 1996;7 Suppl 3:24-6. Unique Identifier : AIDSLINE MED/97030437; Hackett GI; G P Langton Medical Group, Lichfield, Staffs, UK.
Autonomic nervous system disorders and erectile dysfunction.: Int J STD AIDS. 1996;7 Suppl 3:5-8. Unique Identifier : AIDSLINE MED/97030431; Mathias CJ; Department of Medicine, St Mary's Hospital, Imperial College School of; Medicine, UK.
Psychological management of erectile dysfunction and related disorders.: Int J STD AIDS. 1996;7 Suppl 3:9-12. Unique Identifier : AIDSLINE MED/97030432; O'Donoghue F; St Patrick's Hospital, Dublin, Republic of Ireland.
On "Pelvic inflammatory disease in patients seropositive for HIV" [letter]: Eur J Surg. 1996 Aug;162(8):669. Unique Identifier : AIDSLINE MED/97046708; Oosterhuis JW
Persistence of high virus neutralizing antibody titers in cats experimentally infected with feline immunodeficiency virus.: J Vet Med Sci. 1996 Sep;58(9):925-7. Unique Identifier : AIDSLINE MED/97053882; Inoshima Y; Ikeda Y; Kohmoto M; Pecoraro MR; Shimojima M; Shimojima Y; Inada G; Kawaguchi Y; Tomonaga K; Miyazawa T; Mikami T; Department of Veterinary Microbiology, Faculty of Agriculture,; University of Tokyo, Japan.; The development of virus neutralizing (VN) antibody is one of the most effective host defense mechanisms against virus infection. In the present study, we developed a new VN assay against feline immunodeficiency virus (FIV) using a feline T-lymphoblastoid cell line, MYA-1 cells, based on inhibition of viral reverse tr
Pseudouridine for monitoring interferon treatment of patients with chronic hepatitis C.: Eur J Clin Chem Clin Biochem. 1996 Sep;34(9):697-700. Unique Identifier : AIDSLINE MED/97046600; Colonna A; Guadagnino V; Maiorano A; Stamile E; Costa C; Dipartimento di Farmacologia Sperimentale, Universita di Napoli; Federico II, Italy.; Pseudouridine is a modified nucleoside derived from RNA catabolism; the concentration of this nucleoside is elevated in body fluids of both tumour-bearing and human immunodeficiency virus (HIV) infected patients. We used an HPLC procedure to evaluate the serum pseudouridine concentration in patients with chronic hepat
Molecular basis of T lymphocyte CD4 antigen functions.: Eur J Clin Chem Clin Biochem. 1996 Sep;34(9):723-8. Unique Identifier : AIDSLINE MED/97046603; Gaubin M; Autiero M; Houlgatte R; Basmaciogullari S; Auffray C; Piatier-Tonneau D; UPR 420 CNRS, Villejuif, France.; The T cell surface antigen CD4 plays a pivotal role in the MHC class II-restricted response of specific T lymphocytes and serves as the major receptor of human immunodeficiency viruses (HIV). Recent studies have shown the high complexity of CD4 functions in physiological and pathological conditions. We report here a s
Nonpeptidic potent HIV-1 protease inhibitors.: Drug Des Discov. 1996 Apr;13(3-4):15-28. Unique Identifier : AIDSLINE MED/97027954; Prasad JV; Lunney EA; Para KS; Tummino PJ; Ferguson D; Hupe D; Domagala JM; Erickson JW; Department of Chemistry, Parke-Davis Pharmaceutical Research, Division; of Warner-Lambert Company, Ann Arbor, MI 48106-1047, USA.; From an initial mass screening lead, (IC50: 3 microM) and information derived from the X-ray crystallographic structure of a related analog, complexed with HIV protease (PR), the design of more potent inhibitors has been advanced. Various structure-guided approaches to fill P1 and P2 pockets using this pyran-2-one t
Targeting HIV reverse transcriptase for anti-AIDS drug design: structural and biological considerations for chemotherapeutic strategies.: Drug Des Discov. 1996 Apr;13(3-4):29-47. Unique Identifier : AIDSLINE MED/97027955; Arnold E; Das K; Ding J; Yadav PN; Hsiou Y; Boyer PL; Hughes SH; Center for Advanced Biotechnology and Medicine (CABM), Chemistry; Department, Piscataway, NJ, USA.; The reverse transcriptase of HIV is a key target for the antiviral treatment of AIDS. Numerous potent inhibitors of RT have been described including all of the drugs that have been currently licensed for the treatment of AIDS, but their efficacy has been limited by the emergence of drug-resistant HIV variants. Extensi
[Hepatitis B prevention and risk of HIV infection in children injured by discarded needles and/or syringes]: Aten Primaria. 1996 Feb 15;17(2):138-40. Unique Identifier : AIDSLINE MED/97106007; Aragon Pena AJ; Arrazola Martinez MP; Garcia de Codes A; Davila Alvarez FM; de Juanes Pardo JR; Servicio de Medicina Preventiva, Hospital Universitario 12 de Octubre,; Madrid.; OBJECTIVES: Main aim: to study the application of mixed prophylaxis against Hepatitis B viral infection (HB) in children injured by discarded needles and/or syringes. Secondary aim: to find in the group under study the incidence of HIV infection caused by these accidents. DESCRIPTION: Descriptive study. SETTING: 12 de
Oligoclonality of CD8+ T cells in multiple sclerosis.: Autoimmunity. 1996;23(2):127-38. Unique Identifier : AIDSLINE MED/97025589; Monteiro J; Hingorani R; Peroglizzi R; Apatoff B; Gregersen PK; Department of Medicine, North Shore University Hospital/Cornell; University Medical Center, Manhasset, New York 11030, USA.; We have shown earlier that CD8+ T cell oligoclonality occurs frequently in normal individuals and general exhibits a very diverse repertoire. In order to investigate the role of CD8+ T cells in MS, we analysed CD8 oligoclonality in 125 patients with MS in varying stages of disease. A multiplex PCR assay for CDR3 lengt
Both TH1 and TH2 cytokine mRNAs are expressed in the NOD mouse pancreas in vivo.: Autoimmunity. 1996;23(2):99-110. Unique Identifier : AIDSLINE MED/97025586; Faulkner-Jones BE; Dempsey-Collier M; Mandel TE; Harrison LC; Burnet Clinical Research Unit, Walter and Eliza Hall Institute of; Medical Research, Royal Melbourne Hospital, Parkville, Victoria,; Australia.; In NOD mice, autoimmune recognition and destruction of pancreatic islet beta-cells appear to be independently regulated: all mice develop cellular infiltration of the islets (insulitis), but not all develop diabetes. The destructive potential of the insulitis lesion may depend on the balance between the two CD4+ T-cel
Signal transduction in Th clones: target of differential modulation by PGE2 may reside downstream of the PKC-dependent pathway.: Cytokine. 1996 May;8(5):346-56. Unique Identifier : AIDSLINE MED/96336404; Naito Y; Endo H; Arai K; Coffman RL; Arai N; Department of Cell Signalling, DNAX Research Institute of Molecular; and Cellular Biology, Palo Alto, CA 94304-1104, USA.; Lymphokines produced by non-transformed Th clones, Th1 and Th2, were classified into three groups based on their patterns of expression by different stimuli: Group I, GM-CSF and IL-2 , characterized by a strict requirement of activation of both the PKC- and calcium-depe
Murine lymph node antigen presenting cells are the main source of interleukin-6 in the initiation of delayed-type hypersensitivity.: Eur Cytokine Netw. 1996 Sep;7(3):401-7. Unique Identifier : AIDSLINE MED/97112504; Ulrich P; Vohr HW; Institute of Toxicology, Bayer AG, Wuppertal, Germany.; Interleukin-6 (IL-6) and Interferon gamma (IFN-gamma) production was analyzed in mice after topical exposure of the animals to Oxazolone, a well-known contact sensitizer. Since both IL-6 and IFN-gamma had been shown to be involved in the initiation of delayed-type hypersensitivity (DTH) reactions, and especially in co
Donor selection, testing, and inactivation of the HIV virus in freeze-dried bone allografts.: Pract Periodontics Aesthet Dent. 1995 Aug;7(6):13-22; quiz 23. Unique Identifier : AIDSLINE MED/97156494; Mellonig JT; Department of Periodontics, University of Texas Health Science Center; at San Antonio 78284-7894, USA.; This article is a comprehensive review of the safety of currently used freeze-dried bone allografts. The development of exclusionary criteria for donor procurement is discussed along with the steps taken in processing. The processing includes harvesting in a sterile manner, repeated washings, immersion in ethanol, fre
Loss of primitive hematopoietic progenitors in patients with human immunodeficiency virus infection.: Blood. 1996 Dec 15;88(12):4568-78. Unique Identifier : AIDSLINE MED/97131774; Marandin A; Katz A; Oksenhendler E; Tulliez M; Picard F; Vainchenker W; Louache F; INSERM U 362, Institut Gustave Roussy, Villejuif, France.; A number of hematologic abnormalities, including cytopenias, have been observed in patients with human immunodeficiency virus (HIV) infection. To elucidate their mechanisms, primitive cells from bone marrow aspirates of 21 patients with HIV-1 infection were quantitated by flow cytometry. The mean percentage of CD34+ c
Evidence for early B-cell activation preceding the development of Epstein-Barr virus-negative acquired immunodeficiency syndrome-related lymphoma.: Blood. 1996 Dec 15;88(12):4620-9. Unique Identifier : AIDSLINE MED/97131780; Przybylski GK; Goldman J; Ng VL; McGrath MS; Herndier BG; Schenkein DP; Monroe JG; Silberstein LE; Department of Pathology and Laboratory Medicine, University of; Pennsylvania Medical Center, Philadelphia 19104-6082, USA.; To investigate the origin and pathogenesis of acquired immunodeficiency syndrome (AIDS)-related lymphoma (ARL), we studied 14 cases in which Epstein-Barr virus (EBV) infection was not an etiologic factor. By histology, 8 of the specimens were of the small noncleaved cell type and 6 consisted of the large diffuse cell
Detection and distribution of hepatitis C virus-related proteins in lymph nodes of patients with type II mixed cryoglobulinemia and neoplastic or non-neoplastic lymphoproliferation.: Blood. 1996 Dec 15;88(12):4638-45. Unique Identifier : AIDSLINE MED/97131782; Sansonno D; De Vita S; Cornacchiulo V; Carbone A; Boiocchi M; Dammacco F; Department of Biomedical Sciences and Human Oncology, University of; Bari Medical School, Italy.; The role of hepatitis C virus (HCV) in the pathogenesis of type II mixed cryoglobulinemia (MC) has been strongly emphasized in the last few years. Although MC is a benign lymphoproliferative disorder, the risk of overt B-cell malignancy greatly increases during its course. The occurrence of HCV infection in 10% to 30%
Adult T-cell leukemia/lymphoma on a background of clonally expanding human T-cell leukemia virus type-1-positive cells.: Blood. 1996 Dec 15;88(12):4646-50. Unique Identifier : AIDSLINE MED/97131783; Cavrois M; Wain-Hobson S; Gessain A; Plumelle Y; Wattel E; Unite 124 INSERM, Institut de Recherche sur le Cancer de Lille,; France.; Tumorous and nontumorous samples from patients with various forms of adult T-cell leukemia/lymphoma (ATLL) were analyzed using the sensitive inverse polymerase chain reaction (PCR) technique. In all samples, oligoclonal expansion of human T-cell leukemia virus HTLV)-1 bearing T cells were detected, even for the tumoro
Bispecific antibodies target operationally tumor-specific antigens in two leukemia relapse models.: Blood. 1996 Dec 15;88(12):4651-8. Unique Identifier : AIDSLINE MED/97131784; Lindhofer H; Menzel H; Gunther W; Hultner L; Thierfelder S; Forschungszentrum fur Umwelt und Gesundheit (GSF)-Institut fur; Immunologie, Munich, Germany.; Despite improved procedures in chemotherapy and bone marrow transplantation (BMT), post-BMT leukemia relapse rates have remained rather constant in the last decade. Immunotherapy with monoclonal or bispecific antibodies (bsAb) is a promising approach to improve this situation, but is hampered by the absence of tumor-s
Elevated serum levels of soluble Fas/APO-1 in human immunodeficiency virus-infected individuals [letter]: Blood. 1996 Dec 15;88(12):4727-30. Unique Identifier : AIDSLINE MED/97131795; Fadeel B; Samuelsson A; Hachiya T; Brostrom C; Chiodi F
Leishmaniasis: its changing pattern and importance as an imported disease [editorial; comment]: Intern Med. 1996 Jun;35(6):434-5. Unique Identifier : AIDSLINE MED/96432539; Hashiguchi Y
Adult respiratory distress syndrome induced by a Chinese medicine, Kamisyoyo-san [see comments]: Intern Med. 1996 Jun;35(6):494-6. Unique Identifier : AIDSLINE MED/96432551; Shiota Y; Wilson JG; Matsumoto H; Munemasa M; Okamura M; Hiyama J; Marukawa M; Ono T; Taniyama K; Mashiba H; Department of Clinical Research, Kure Kyosai Hospital.; We report the first case of Kamisyoyo-san-induced adult respiratory distress syndrome (ARDS). A 59-year-old female was given Kamisyoyo-san for treatment of seborrheic dermatitis. She then presented with a respiratory illness having clinical, radiologic and functional characteristics of ARDS. Bronchoalveolar lavage flu
Cryptococcus neoformans: paradigm for the role of antibody immunity against fungi?: Zentralbl Bakteriol. 1996 Aug;284(4):475-95. Unique Identifier : AIDSLINE MED/97055681; Pirofski LA; Casadevall A; Division of Infectious Diseases, Albert Einstein College of Medicine,; Bronx, New York, USA.; Cryptococcus neoformans is an encapsulated fungus that is a frequent cause of life-threatening infections in patients with AIDS. C. neoformans has many similarities with encapsulated bacteria such as S. pneumoniae and H. influenzae for which antibody immunity is important in protection. However the role of antibody im
Development of pseudopeptide inhibitors of HIV-1 aspartic protease: analysis and tuning of the subsite specificity.: Pept Res. 1995 Nov-Dec;8(6):328-34. Unique Identifier : AIDSLINE MED/96435530; Tossi A; Antcheva N; Romeo D; Miertus S; University of Trieste, Italy.; HIV-1 aspartic protease (PR) is a promising target for acquired immunodeficiency syndrome (AIDS) therapy, and the development of PR inhibitors can be accelerated by computer-aided design methods. We describe an approach for the design of new inhibitors, based on the modification of a known reference inhibitor, and the
Effect of amino acid replacements, additions and deletions on the antiviral activity of a peptide derived from the HIV-1 GP41 sequence.: Pept Res. 1995 Nov-Dec;8(6):345-8. Unique Identifier : AIDSLINE MED/96435532; Jiang S; Lin K; New York Blood Center, New York, USA.; We demonstrated that a synthetic peptide EWDREINNYTSLIHSLIEESQNQQEKNEQEGGC), designated SJ-2176, corresponding to the HIV-1 IIIB gp41 sequence (637-666), inhibited HIV-1 replication, virus-induced cell-cell fusion and cytopathic effects in both CD4+ T and monocytic cell lines. In this study, we show that lengthening t
Concordant lung xenograft rejection in a hamster-to-rat model.: Surg Today. 1996;26(10):793-9. Unique Identifier : AIDSLINE MED/97053048; Nagayasu T; Kawahara K; Takahashi T; Yamamoto S; Ayabe H; First Department of Surgery, Nagasaki University School of Medicine,; Japan.; This study was conducted to investigate the functional and morphological aspects of orthotopic lung xenograft rejection in a concordant hamster-to-rat donor-recipient species combination. By postoperative day (POD) 3, allotransplanted grafts demonstrated good aeration, but infiltrates were seen in all the xenotranspla
Local and systemic immune response to inactivated Candida albicans in mice.: Nat Immun. 1995 Sep;14(5-6):234-49. Unique Identifier : AIDSLINE MED/97087879; Scaringi L; Rosati E; Cornacchione P; Fettucciari K; Sabatini R; Biondi R; Mezzasoma L; Valiani M; D'Errico P; Marconi P; Department of Clinical Medicine, University of Perugia, Policlinico; Monteluce, Italy.; To improve our understanding of the role natural-immunity cells play in regulating the immune response to Candida albicans (CA) we compared local versus systemic effects of intraperitoneal inoculations with inactivated CA cells in mice. Peritoneal exudate cells (PECs) and spleen cells (SCs) were recovered from CD2F1 m
Peripheral lymphoid tissue-like adhesion molecule expression in nodular infiltrates in inflammatory myopathies.: Neuromuscul Disord. 1996 Aug;6(4):255-60. Unique Identifier : AIDSLINE MED/97042755; De Bleecker JL; Engel AG; Butcher EC; University Hospital, Department of Neurology, Gent, Belgium.; Non-granulomatous nodular accumulations of inflammatory cells in inflammatory myopathies were studied to characterize adhesion mechanisms used for leukocyte recruitment. The nodules had a B-cell-rich center surrounded by a helper T-cell-rich peripheral zone, resembling lymph nodes. The T-cell-rich zones harbored high-
Activation of the transcription from the human immunodeficiency virus type 1 (HIV-1) long terminal repeat by autologous and heterologous cell-to-cell contact.: Cell Mol Biol (Noisy-le-grand). 1996 Sep;42(6):811-23. Unique Identifier : AIDSLINE MED/97046427; Faure E; Lecine P; Imbert J; Champion S; Institut de Chimie Biologique, Universite de Provence, Marseille,; France.; Recent studies have demonstrated that the activation of HIV-1 provirus and of the Long Terminal Repeat of HIV-1 (HIV-1-LTR) may occur upon cell-to-cell contact between peripheral blood lymphocytes (PBLs) and infected or transfected (HT29) human colonic carcinoma cells. Using transient or stable transfections, we ascer
Structure of equine infectious anemia virus proteinase complexed with an inhibitor.: Protein Sci. 1996 Aug;5(8):1453-65. Unique Identifier : AIDSLINE MED/97001845; Gustchina A; Kervinen J; Powell DJ; Zdanov A; Kay J; Wlodawer A; Macromolecular Structure Laboratory, NCI-Frederick Cancer Research and; Development Center, Maryland 21702, USA.; Equine infectious anemia virus (EIAV), the causative agent of infectious anemia in horses, is a member of the lentiviral family. The virus-encoded proteinase (PR) processes viral polyproteins into functional molecules during replication and it also cleaves viral nucleocapsid protein during infection. The X-ray structu
Phage display of intact domains at high copy number: a system based on SOC, the small outer capsid protein of bacteriophage T4.: Protein Sci. 1996 Sep;5(9):1833-43. Unique Identifier : AIDSLINE MED/97035251; Ren ZJ; Lewis GK; Wingfield PT; Locke EG; Steven AC; Black LW; Department of Biological Chemistry, University of Maryland School of; Medicine, Baltimore 21201, USA.; Peptides fused to the coat proteins of filamentous phages have found widespread applications in antigen display, the construction of antibody libraries, and biopanning. However, such systems are limited in terms of the size and number of the peptides that may be incorporated without compromising the fusion proteins c
Arrest of in vitro T cell differentiation of normal bone marrow-derived CD34+ stem cells with thymic epithelial fragments from children with AIDS.: Stem Cells. 1996 Sep;14(5):533-47. Unique Identifier : AIDSLINE MED/97043296; Ruiz ME; Freeman J; Bouhasin JD; Knutsen AP; Hendrix MJ; Pediatric Research Institute, Saint Louis University School of; Medicine, Missouri, USA.; A novel approach is presented to assess the ability of thymic tissues obtained from children with end stage AIDS to attract normal bone marrow (BM)-derived CD34+ (lineage negative) stem cells (SCs) and support lymphopoiesis in vitro. Chemokinesis of BM-derived CD34+ SCs was analyzed by time-lapse videomicroscopy to as
[Theoretical conformational NMR analysis of peptide RP342 of the immunogenic fragment of HIV-1 protein gp120]: Dokl Akad Nauk. 1996 Nov;351(3):401-3. Unique Identifier : AIDSLINE MED/97145563; Andrianov AM; Akhrem AA
Binding properties of human immunodeficiency virus type-2 (HIV-2) RNA corresponding to the packaging signal to its nucleocapsid protein.: Biochem Mol Biol Int. 1996 Sep;40(1):33-42. Unique Identifier : AIDSLINE MED/97040977; Tsukahara T; Komatsu H; Kubo M; Obata F; Tozawa H; Department of Immunology, School of Allied Health Sciences, Kitasato; University, Kanagawa, Japan.; The nucleocapsid (NC) protein of human immunodeficiency virus type-1 (HIV-1) contains two zinc finger motifs (ZFMs), and binds specifically to the packaging signal which is located in the 5 leader sequence of the viral genomic RNA between the first splice donor and the gag initiator codon (AUG). In this study, we ana
Safety of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in patients with human immunodeficiency virus infection: a pilot study.: Pharm World Sci. 1996 Jan;18(1):30-4. Unique Identifier : AIDSLINE MED/97014996; Arends S; van Halteren E; Kamp W; Schokker J; 'Fight for Life', Keizersgracht 670, Amsterdam, The Netherlands.; The compound 9-(2-phosphonylmethoxyethyl)adenine (PMEA) is a potent inhibitor of a number of viruses in vitro such as human immunodeficiency virus types 1 and 2, herpes simplex virus types 1 and 2, hepatitis B virus, cytomegalovirus , and Epstein-Barr virus. PMEA also proved to be e
Macrophage release of tumor necrosis factor-alpha by Mycobacterium avium antigens.: FEMS Immunol Med Microbiol. 1996 Aug;15(1):27-34. Unique Identifier : AIDSLINE MED/97024889; Rao SP; Ratnakar P; Catanzaro A; Department of Medicine, University of California San Diego, UCSD; Medical Center 92103-8374, USA. srao@ucsd.edu; Mycobacterium avium complex (MAC) infection is the most common disseminated opportunistic infection encountered in patients with AIDS. We have studied the ability of specific Mycobacterium avium MA) antigen to stimulate human monocyte-derived macrophages MDM) to produce tumor necrosis factor-alpha (TNF-alpha). MDM sti
Th1- and Th2-type cytokines regulate chemokine expression.: Biol Signals. 1996 Jul-Aug;5(4):197-202. Unique Identifier : AIDSLINE MED/97046273; Kunkel SL; Department of Pathology, University of Michigan Medical School, Ann; Arbor, USA.; The recruitment of various leukocyte populations to an area of injured and inflamed tissue is one of the most fundamental host defense responses. Historic evidence supports the concept that the pathology of acute inflammation is characterized by the elicitation of neutrophils, while the leukocyte composition of more c
Amebic liver abscess.: J Gastroenterol. 1996 Oct;31(5):659-63. Unique Identifier : AIDSLINE MED/97041760; Fujihara T; Nagai Y; Kubo T; Seki S; Satake K; Department of Surgery, Osaka Socio-Medical Center, Japan.; We report eight cases of amebic liver abscess. All patients were men, and four were homosexual. Five of the eight patients had syphilis, but the four homosexual patients who were tested for HIV infection were negative. Ultrasonography (US), with or without needle aspiration, is the best method for diagnosing amebic li
Spontaneous hepatitis B surface antigen clearance in a long-term follow-up study of patients with chronic type B hepatitis. Lack of correlation with hepatitis C and D virus superinfection.: J Gastroenterol. 1996 Oct;31(5):696-701. Unique Identifier : AIDSLINE MED/97041766; Da Silva LC; Madruga CL; Carrilho FJ; Pinho JR; Saez-Alquezar A; Santos C; Bassit L; Barreto C; Fonseca LE; Alves VA; Leitao R; Vianna R; Cardoso RA; Franca AV; Gayotto LC; Department of Gastroenterology, University of Sao Paulo School of; Medicine, Brazil.; We investigated the frequency of HBsAg clearance and the possible role of viral superinfection in a long-term follow-up of 184 patients with chronic hepatitis B (CHB). Our subjects were 184 patients with chronic hepatitis B and the follow-up was 12-216 months (mean 66.2 +/- 53.7 months). The investigative methods used
Public comment sought on HIV/AIDS [news]: Aust Nurs J. 1996 Nov;4(5):12. Unique Identifier : AIDSLINE MED/97158777; Prenesti S
The lack of association of marijuana and other recreational drugs with progression to AIDS in the San Francisco Men's Health Study.: Ann Epidemiol. 1996 Jul;6(4):283-9. Unique Identifier : AIDSLINE MED/97030910; Di Franco MJ; Sheppard HW; Hunter DJ; Tosteson TD; Ascher MS; Department of Epidemiology, Harvard School of Public Health, Boston,; MA 02115, USA.; We evaluated the associations of specific recreational drugs and alcohol with laboratory predictors of AIDS at entry into the San Francisco Men s Health Study (SFMHS) in 1984 and with the development of the acquired immunodeficiency syndrome (AIDS) during 6 years of follow-up. Marijuana use was associated with a decre
Western blot banding patterns of HIV rapid progressors in the U.S. Navy Seropositive Cohort: implications for vaccine development. Navy Retroviral Working Group.: Ann Epidemiol. 1996 Jul;6(4):341-7. Unique Identifier : AIDSLINE MED/97030917; Garland FC; Garland CF; Gorham ED; Brodine SK; Department of Health Sciences, Naval Health Research Center, San; Diego, CA 92186-5122, USA.; Although human immunodeficiency virus (HIV) infection is progressive, the rate of decline in CD4+ lymphocyte counts varies. The role of immune system components in limiting HIV infection has yet to be defined, but a previous report on the U.S. Navy HIV Seropositive Cohort reported that strong reactivity in the anti-p5
Safer sex behavior and alcohol consumption. Research Group of the Swiss HIV Prevention Study.: Ann Epidemiol. 1996 Jul;6(4):357-64. Unique Identifier : AIDSLINE MED/97030919; Lauchli S; Heusser R; Tschopp A; Gutzwiller F; Institute of Social and Preventive Medicine, University of Zurich,; Switzerland.; To test the hypothesis that safer sex procedures are less consistently observed by persons under the influence of alcohol, data from the Swiss human immunodeficiency virus (HIV) Prevention Study (HIPS) were evaluated. HIPS is a large prospective cohort study involving 724 HIV-negative and mainly heterosexual subjects
Laparoscopically assisted sigmoid colectomy in human immunodeficiency virus (HIV) patients: a good indication for laparoscopic surgery.: Surg Laparosc Endosc. 1996 Oct;6(5):414-6. Unique Identifier : AIDSLINE MED/97045378; Oliveira L; Wexner SD; Department of Colorectal Surgery, Cleveland Clinic Florida, Fort; Lauderdale, Florida 33309, USA.; Laparoscopic colorectal procedures have been accepted for a variety of conditions. We present two cases of HIV-positive who underwent laparoscopic sigmoid colectomy and creation of a stoma for the treatment of sigmoid cancer and disseminated colorectal kaposi sarcoma, respectively. Laparoscopy may be a good option in
Differences in the contribution of CD4+ T cells to proislet and islet allograft rejection correlate with constitutive class II MHC alloantigen expression.: Cell Transplant. 1996 Sep-Oct;5(5):525-41. Unique Identifier : AIDSLINE MED/97044141; Simeonovic CJ; Brown DJ; Townsend MJ; Wilson JD; Division of Molecular Medicine, John Curtin School of Medical; Research, Australian National University, Canberra, A.C.T., Australia.; Allografts of BALB/c (H-2d) fetal proislets facilitated long-term > 100 days) reversal of streptozotocin-induced diabetes in CBA/H H-2k) mice treated with a combination of anti-CD4 and anti CD8 mAbs. Anti-CD8 monotherapy was partially effective in restoring normoglycemia but anti-CD4 mAb treatment of host animals fail
HHV-8: a new herpesvirus associated with Kaposi's sarcoma.: Trends Microbiol. 1996 Oct;4(10):383-6. Unique Identifier : AIDSLINE MED/97055676; Offermann MK; Dept of Medicine, Emory University, Atlanta, GA 30322, USA.; mofferm@emory.edu; Kaposi s sarcoma (KS) is a multifocal neoplasm that develops in a high proportion of HIV-infected homosexual men. KS lesions contain novel herpes-like DNA sequences (HHV-8), and recent studies characterizing HHV-8 and its association with KS, and with other diseases, suggest that HHV-8 may represent the etiological vi
15-Deoxyspergualin inhibits interleukin 6 production in in vitro stimulated human lymphocytes.: Transpl Immunol. 1996 Jun;4(2):133-43. Unique Identifier : AIDSLINE MED/97000505; Borg AJ; Kumagai-Braesch M; Moller E; Department of Immunology, Microbiology, Pathology and Infectious; Diseases, Karolinska Institute, Huddinge Hospital, Sweden.; Experimental data show that relatively low concentrations of 15-deoxyspergualin (DSG) inhibit the induction of cytotoxic T lymphocytes (CTL) and the generation of antibody-producing cells. Considerably higher concentrations of DSG are required to inhibit proliferative responses. In this in vitro study, the effects of
The design and synthesis of 2,5-linked pyrrolinones. A potential non-peptide peptidomimetic scaffold.: Bioorg Med Chem. 1996 Jul;4(7):1021-34. Unique Identifier : AIDSLINE MED/96428871; Smith AB 3rd; Knight SD; Sprengeler PA; Hirschmann R; Department of Chemistry, University of Pennsylvania, Philadelphia; 19104, USA.; The de novo design and initial synthetic studies directed toward construction of a novel non-peptide scaffold for beta-strand/sheet and related secondary peptide structural mimics are described. The scaffold, consisting of a repeating array of 2,5,5-trisubstituted pyrrolinone (enaminone) units punctuated with appropri
Structure-activity relationships of HIV-1 PR inhibitors containing AHPBA--II. Modification of pyrrolidine ring at P1' proline.: Bioorg Med Chem. 1996 Aug;4(8):1365-77. Unique Identifier : AIDSLINE MED/97033902; Komai T; Higashida S; Sakurai M; Nitta T; Kasuya A; Miyamaoto S; Yagi R; Ozawa Y; Handa H; Mohri H; Yasuoka A; Oka S; Nishigaki T; Kimura S; Shimada K; Yabe Y; Biological Research Laboratories, Sankyo Co. Ltd, Tokyo, Japan.; Systematic replacement in the 3- or 4-position of the pyrrolidine ring at P1 proline was carried out. Compound 26, which has a Cl atom in the 4(S)-position was the most active among inhibitors substituted with other halogen atoms or other substituents. Furthermore, the replacement of the Z group in compound 26 with f
Cofactors provide the entry keys. HIV-1.: Curr Biol. 1996 Sep 1;6(9):1051-3. Unique Identifier : AIDSLINE MED/96398945; Wilkinson D; Chester Beatty Laboratories, Institute of Cancer Research, 237 Fulham; Road, London SW3 6JB UK.; The identification of the cofactors required for HIV-1 entry into cells promises to provide new insights into viral transmission and pathogenesis, and opens new avenues for AIDS therapy and prophylaxis.
HIV-1, Vpr and the cell cycle.: Curr Biol. 1996 Sep 1;6(9):1096-103. Unique Identifier : AIDSLINE MED/96398960; Emerman M; Room C2-023, Fred Hutchinson Cancer Research Center, 1124 Columbia; Street, Seattle, Washington 98104, USA.; The human immunodeficiency virus 1 (HIV-1) is a complex retrovirus with more genes than most retroviruses. One of these extra genes codes for a protein called Vpr, which has recently been shown to prevent activation of the mitotic cyclin-dependent kinase and thereby prevent infected cells from undergoing mitosis and p
Changes in blood and spleen lymphocyte populations following antigen challenge in immature male chickens.: Br Poult Sci. 1996 Sep;37(4):819-27. Unique Identifier : AIDSLINE MED/97049496; Trout JM; Mashaly MM; Siegel HS; Department of Poultry Science, Pennsylvania State University,; University Park 16802-3501, USA.; 1. The effects of antigen (Ag) injection on the distribution of lymphocyte populations of Cornell K-strain male chickens were studied. 2. Two experiments were conducted. In the first, chickens were injected with Brucella abortus (BA), a purported T-independent antigen. In the second, chickens were injected with sheep
Immunologic changes associated with strenuous exercise [letter]: Clin J Sport Med. 1996 Oct;6(4):277-8. Unique Identifier : AIDSLINE MED/97049615; Shek PN
Protein-drug complexes important for immunoregulation and organ transplantation.: Curr Opin Struct Biol. 1996 Dec;6(6):838-47. Unique Identifier : AIDSLINE MED/97148253; Navia MA; Vertex Pharmaceuticals Incorporated, Cambridge, MA 02139-4242, USA.; navia@vpharm.com; Recently, two structures of the Ser/Thr phosphorylase calcineurin in complex with FK506 and its cognate immunophilin, FKBP12, have been reported, both solved by small pharmaceutical companies focused on structure-based drug design. A realization, however, that the toxicities associated with calcineurin-mediated immuno
New products and research bring guarded optimism, new questions about AIDS therapy [news]: Am J Health Syst Pharm. 1996 Sep 15;53(18):2129-30, 2132. Unique Identifier : AIDSLINE MED/97033656; Miller JL
Nonnucleoside reverse transcriptase inhibitor marketed for AIDS therapy [news]: Am J Health Syst Pharm. 1996 Sep 15;53(18):2132-3. Unique Identifier : AIDSLINE MED/97033657
Prevention and treatment of drug-resistant tuberculosis.: Am J Health Syst Pharm. 1996 Oct 1;53(19):2291-8; quiz 2335-6. Unique Identifier : AIDSLINE MED/97048231; Humma LM; University of Georgia, Athens, USA.; Therapy recommended for preventing and treating drug-resistant tuberculosis is discussed. Drug-resistant strains of Mycobacterium tuberculosis can be transmitted by an infected individual, or resistance can be acquired during therapy for drug-susceptible disease. At least until susceptibility test data are available,
Comparison of absolute CD4+ lymphocyte counts determined by enzyme immunoassay (TRAx CD4 test kit) and flow cytometry.: Clin Diagn Lab Immunol. 1996 Jul;3(4):371-3. Unique Identifier : AIDSLINE MED/96400822; Moss MW; Carella AV; Provost V; Quinn TC; Department of Medicine, Johns Hopkins University School of Medicine,; Baltimore, MD 21205, USA.; Currently, CD4+ lymphocyte counts are one of the most widely used surrogate markers for monitoring disease progression in and initiating therapy for human immunodeficiency virus-infected individuals. However, the process of obtaining lymphocyte subset counts can be complex and expensive, often rendering the test inacc
Antibody to native human immunodeficiency virus type 1 envelope glycoproteins induced by IIIB and MN recombinant gp120 vaccines. The NIAID AIDS Vaccine Evaluation Group.: Clin Diagn Lab Immunol. 1996 Jul;3(4):378-86. Unique Identifier : AIDSLINE MED/96400824; Gorse GJ; Patel GB; Newman FK; Belshe RB; Berman PW; Gregory TJ; Matthews TJ; Division of Infectious Diseases and Immunology, Saint Louis; University, Missouri, USA.; The ability of antibody induced by MN and IIIB recombinant gp120 rgp120) human immunodeficiency virus type 1 (HIV-1) vaccines the bind to oligomeric native and monomeric recombinant HIV-1 envelope glycoproteins (rgp 120) was measured in 25 uninfected, healthy adult volunteers. A major focus was to evaluate the effect
Detection of altered T helper 1 and T helper 2 cytokine production by peripheral blood mononuclear cells in patients with multiple sclerosis utilizing intracellular cytokine detection by flow cytometry and surface marker analysis.: Clin Diagn Lab Immunol. 1996 Jul;3(4):411-6. Unique Identifier : AIDSLINE MED/96400829; Crucian B; Dunne P; Friedman H; Ragsdale R; Pross S; Widen R; Department of Medical Microbiology and Immunology, College of; Medicine, University of South Florida, Tampa 33612, USA.; Production of T helper 1 and T helper 2 cytokines was investigated in peripheral blood mononuclear cells (PBMCs) from multiple sclerosis (MS) patients by a newly described technique, detection of intracellular cytokines by flow cytometry in conjunction with immunophenotype analysis. T-cell gamma interferon (IFN-gamma)
A field test for the detection of antibodies to human immunodeficiency virus types 1 and 2 in serum or plasma.: Clin Diagn Lab Immunol. 1996 Jul;3(4):480-2. Unique Identifier : AIDSLINE MED/96400842; Burgess-Cassler A; Barriga Angulo G; Wade SE; Castillo Torres P; Schramm W; Saliva Diagnostic Systems, Inc., Vancouver, Washington 98682-2444,; USA.; In response to the need for simple and rapid tests for infectious diseases, we have devised a test for antibodies to human immunodeficiency virus type 1 (HIV-1) and HIV-2 which resembles many contemporary strip-style pregnancy tests in format and ease of use. The test was evaluated with 2,928 serum specimens (1,541 re
Type 1 and type 2 cytokine profiles in children exposed to or infected with vertically transmitted human immunodeficiency virus.: Clin Diagn Lab Immunol. 1996 Sep;3(5):493-9. Unique Identifier : AIDSLINE MED/97031198; Lee BN; Lu JG; Kline MW; Paul M; Doyle M; Kozinetz C; Shearer WT; Reuben JM; Division of Laboratory Medicine, University of Texas M. D. Anderson; Cancer Center, Houston 77030, USA.; In human immunodeficiency virus (HIV)-infected adults, cytokine production profiles switch from predominantly type 1 interleukin-2 [ IL-2 ] and gamma interferon [IFN-gamma]) to type 2 IL-4 and IL-10) cytokines with disease progression. To test this hypothesis in vertical
Differential effects of interleukin-12, interleukin-15, and interleukin-2 on human immunodeficiency virus type 1 replication in vitro.: Clin Diagn Lab Immunol. 1996 Sep;3(5):547-53. Unique Identifier : AIDSLINE MED/97031207; Bayard-McNeeley M; Doo H; He S; Hafner A; Johnson WD Jr; Ho JL; Department of Medicine, Cornell University Medical College, New York; 10021, USA.; Cytokines may have clinical utility as therapeutic agents for human immunodeficiency virus type 1 (HIV-1) infection and as an adjuvant for vaccines. The effect of interleukin-12 (IL-12) and IL-15 on in vitro HIV-1 replication was investigated. IL-12 and IL-15 at doses up to 10 ng/ml had little effect on basal HIV-1 p2
Prevalence of antibodies to feline parvovirus, calicivirus, herpesvirus, coronavirus, and immunodeficiency virus and of feline leukemia virus antigen and the interrelationship of these viral infections in free-ranging lions in east Africa.: Clin Diagn Lab Immunol. 1996 Sep;3(5):554-62. Unique Identifier : AIDSLINE MED/97031208; Hofmann-Lehmann R; Fehr D; Grob M; Elgizoli M; Packer C; Martenson JS; O'Brien SJ; Lutz H; Department of Internal Veterinary Medicine, University of Zurich,; Switzerland. rhofmann@vetklinik.unizh.ch; While viral infections and their impact are well studied in domestic cats, only limited information is available on their occurrence in free-ranging lions. The goals of the present study were (i) to investigate the prevalence of antibodies to feline calicivirus (FCV), herpesvirus (FHV), coronavirus (FCoV), parvovirus
Comparison of two 2,3-diacyl trehalose antigens from Mycobacterium tuberculosis and Mycobacterium fortuitum for serology in tuberculosis patients.: Clin Diagn Lab Immunol. 1996 Sep;3(5):563-6. Unique Identifier : AIDSLINE MED/97031209; Tortola MT; Laneelle MA; Martin-Casabona N; Servico de Microbiologia y Parasitologia, Ciudad Sanitaria y; Universitaria Vall d'Hebron, Barcelona, Spain.; Immunoglobulin G antibodies against two 2,3-diacyl trehalose DAT) antigens from Mycobacterium tuberculosis (DATT) and Mycobacterium fortuitum (DATF) were studied by enzyme-linked immunosorbent assay of 356 serum samples. The sera were obtained from non-tuberculosis-infected individuals (282 serum samples) and tubercul
Unusually high seroprevalence of Borna disease virus in clade E human immunodeficiency virus type 1-infected patients with sexually transmitted diseases in Thailand.: Clin Diagn Lab Immunol. 1996 Sep;3(5):590-3. Unique Identifier : AIDSLINE MED/97031215; Auwanit W; Ayuthaya PI; Nakaya T; Fujiwara S; Kurata T; Yamanishi K; Ikuta K; Section of Serology, Hokkaido University, Sapporo, Japan.; The seroprevalence of Borna disease virus (BDV) in human immunodeficiency virus type 1-infected individuals in Thailand was examined by using recombinant BDV p24. A high (38 to 48%) rate of seroprevalence of BDV was observed in clade E-infected patients with sexually transmitted
Lymphocyte subset diversity in idiopathic CD4+ T lymphocytopenia.: Clin Diagn Lab Immunol. 1996 Sep;3(5):611-3. Unique Identifier : AIDSLINE MED/97031221; Tassinari P; Deibis L; Bianco N; Echeverria de Perez G; Instituto de Immunologia, Facultad de Medicina, Universidad Central de; Venezuela, Caracas, Venezuela.; The clinical and public health importance of CD4+ T lymphocytopenia without human immunodeficiency virus infection is still unclear. We describe herein two new human immunodeficiency virus-negative patients with low numbers of peripheral CD4+ T cells and opportunistic infections (cerebral toxoplasmosis and tuberculosi
Mechanisms in interleukin-2 protection against glucocorticoid-induced apoptosis: regulation of AP-1 and glucocorticoid receptor transcriptional activities.: J Interferon Cytokine Res. 1996 Aug;16(8):601-9. Unique Identifier : AIDSLINE MED/97031825; Guizani L; Perrin-Wolff M; Breard J; Binetruy B; Bertoglio J; CJF INSERM 93-01, Faculte de Pharmacie-Paris XI, Chatenay Malabry,; France.; We have used the gibbon ape leukemia cell line MLA-144 and its corticoid-sensitive subclone MLA-E7T to analyze the mechanisms whereby interleukin-2 ( IL-2 ) can protect T cells against dexamethasone-induced apoptosis. MLA cells are characterized by the constitutive expre
T-lymphocyte subpopulations (CD4, CD8), IL-4 and IFN-gamma concentration in stimulated cell culture (PBMC) in children with atopic dermatitis.: Rocz Akad Med Bialymst. 1995;40(3):474-9. Unique Identifier : AIDSLINE MED/96371458; Boznanski A; Machnicki M; Department of Pediatric and Allergology Medical Academy, Wroclaw.; The study was carried out on a group of children with atopic dermatitis. We were looking for a correlation between the percentages of CD4, CD8 lymphocytes and IFN-gamma and IL-4 concentrations in stimulated PHA cells cultures (PBMC). On the ground of obtained results, a statistically significant increase of IL-4 conce
The microbial plague continues [editorial]: Nat Med. 1997 Jan;3(1):1. Unique Identifier : AIDSLINE MED/97140242; Culliton BJ
Live-attenuated HIV vaccines: how safe is safe enough? [news; comment]: Nat Med. 1997 Jan;3(1):17-8. Unique Identifier : AIDSLINE MED/97140246; Murphey-Corb M
Another way to generate T cells? [news]: Nat Med. 1997 Jan;3(1):18-9. Unique Identifier : AIDSLINE MED/97140247; Metcalf D
Resistance of neonatal monkeys to live attenuated vaccine strains of simian immunodeficiency virus [see comments]: Nat Med. 1997 Jan;3(1):32-6. Unique Identifier : AIDSLINE MED/97140255; Wyand MS; Manson KH; Lackner AA; Desrosiers RC; TSI Mason Laboratories, Worcester, Massachusetts 01608, USA.; A major safety concern of using live-attenuated vaccine strategies against AIDS is the potential exposure of neonates or fetuses to vaccine virus from the mother. Here we report that high viral loads and disease were observed in only 2 of 18 neonatal monkeys infected with gene-deleted vaccine strains of simian immunod
A new transmissible AIDS-like disease in mice induced by alloimmune stimuli.: Nat Med. 1997 Jan;3(1):37-41. Unique Identifier : AIDSLINE MED/97140256; Ter-Grigorov VS; Krifuks O; Liubashevsky E; Nyska A; Trainin Z; Toder V; Department of Immunology and Pathology, Kimron Veterinary Institute,; Bet-Dagan, Israel.; The search for a suitable and reliable animal model for human AIDS that is easy to use on a large scale continues. Here we describe a new condition in mice that closely resembles human AIDS, namely, chronic lymphoproliferation with dramatic depletion of CD4-positive cells, progressive impairment of the immune response
Transcytosis of infectious human immunodeficiency virus across a tight human epithelial cell line barrier.: Nat Med. 1997 Jan;3(1):42-7. Unique Identifier : AIDSLINE MED/97140257; Bomsel M; U. 332, Institut Cochin de Genetique Moleculaire, 22, Paris, France.; Contact between various epithelial cell lines and HIV chronically infected mononuclear cell lines results in a massive and rapid budding of HIV virions toward the epithelium followed by their internalization into epithelial endosome-like structures. Here it is shown that as early as 30 minutes after apical contact, pr
The expression cassette determines the functional activity of ribozymes in mammalian cells by controlling their intracellular localization.: RNA. 1997 Jan;3(1):75-88. Unique Identifier : AIDSLINE MED/97144634; Bertrand E; Castanotto D; Zhou C; Carbonnelle C; Lee NS; Good P; Chatterjee S; Grange T; Pictet R; Kohn D; Engelke D; Rossi JJ; Department of Molecular Biology, Beckman Research Institute of the; City of Hope, Duarte, California 91010, USA.; In order to better understand the influence of RNA transcript context on RNA localization and catalytic RNA efficacy in vivo, we have constructed and characterized several expression cassettes useful for transcribing short RNAs with well defined 5 and 3 appended flanking sequences. These cassettes contain promoter s
Periodontal manifestations of systemic diseases and their management.: J Can Dent Assoc. 1996 Apr;62(4):313-4, 317-21. Unique Identifier : AIDSLINE MED/97105004; Michelberger D; Matthews D; University of Western Ontario, London.; Periodontal diseases result from the response of the host s periodontal tissue to the bacterial toxins present in dental plaque. Several systemic diseases have been shown to influence the course and severity of periodontal diseases by altering the inflammatory response of the host. This paper focuses on the manifestat
Th1 and Th2 responses regulate experimental lung granuloma development.: Sarcoidosis Vasc Diffuse Lung Dis. 1996 Sep;13(2):120-8. Unique Identifier : AIDSLINE MED/97048544; Kunkel SL; Lukacs NW; Strieter RM; Chensue SW; Department of Pathology, University of Michigan Medical School, Ann; Arbor 48109-0602, USA.; The pathogenesis of chronic interstitial lung disease is often characterized as an intense inflammatory response with accompanying fibroproliferation and deposition of extracellular matrix. Certain of these lung disorders share common characteristics, including an unknown etiology, ill defined mechanisms of initiation
Apoptosis in human ejaculated sperm cells (notulae seminologicae 9).: J Submicrosc Cytol Pathol. 1996 Oct;28(4):587-96. Unique Identifier : AIDSLINE MED/97087803; Baccetti B; Collodel G; Piomboni P; Institute of General Biology, University of Siena, Italy.; In this work we apply the Hoechst 33258 DNA staining, the TUNEL procedure and conventional electron microscopy to study the ejaculate of fertile and infertile men, in order to detect apoptosis in human sperm cells. We have observed that apoptosis is abnormally frequent in the sperm cells of the ejaculate of sterile me
New features in RNA recognition: a Tat-TAR complex.: Chem Biol. 1996 Jan;3(1):17-9. Unique Identifier : AIDSLINE MED/97113214; Wemmer DE; Department of Chemistry, University of California, Berkeley, CA; 94720-1460, USA.; The structure of a peptide from the BIV Tat protein bound to its cognate TAR RNA has been solved. This structure reveals a beta-hairpin motif for the protein, bound at a widened bulge site in the major groove of the RNA.
A non-canonical base pair within the human immunodeficiency virus rev-responsive element is involved in both rev and small molecule recognition.: Chem Biol. 1996 Feb;3(2):129-37. Unique Identifier : AIDSLINE MED/97113231; Werstuck G; Zapp ML; Green MR; Program in Molecular Medicine, Howard Hughes Medical Institute, UMASS; Medical Center, Worcester, MA, 01605, USA.; BACKGROUND: Human immunodeficiency virus (HIV) replication depends on the interaction of an HIV regulatory protein, Rev, with a viral RNA element (the Rev-responsive element, RRE). The high affinity RRE core region contains a non-canonical base pair G48:G71) that is important for Rev recognition. Aminoglycoside antibi
Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450.: Chem Biol. 1996 Apr;3(4):301-14. Unique Identifier : AIDSLINE MED/97113251; Hodge CN; Aldrich PE; Bacheler LT; Chang CH; Eyermann CJ; Garber S; Grubb M; Jackson DA; Jadhav PK; Korant B; Lam PY; Maurin MB; Meek JL; Otto MJ; Rayner MM; Reid C; Sharpe TR; Shum L; Winslow DL; Erickson-Viitanen S; Department of Chemical Sciences, DuPont Merck Pharmaceutical Co.,; Wilmington, DE 19880, USA. hodgecn@carbon.dmpc.com; BACKGROUND: Effective HIV protease inhibitors must combine potency towards wild-type and mutant variants of HIV with oral bioavailability such that drug levels in relevant tissues continuously exceed that required for inhibition of virus replication. Computer-aided
Social inequalities and emerging infectious diseases.: Emerg Infect Dis. 1996 Oct-Dec;2(4):259-69. Unique Identifier : AIDSLINE MED/97125926; Farmer P; Harvard Medical School, Department of Social Medicine, Boston, MA; 02115, USA. pefarmer@bics.bwh.harvard.edu; Although many who study emerging infections subscribe to social-production-of-disease theories, few have examined the contribution of social inequalities to disease emergence. Yet such inequalities have powerfully sculpted not only the distribution of infectious diseases, but also the course of disease in those affect
A mathematical model and CD4+ lymphocyte dynamics in HIV infection.: Emerg Infect Dis. 1996 Oct-Dec;2(4):299-305. Unique Identifier : AIDSLINE MED/97125929; Hraba T; Dolezal J; Institute of Molecular Genetics, Prague, Czech Republic.; tomas.hraba@img.cas.cz; The paper presents a model of CD4 + lymphocyte dynamics in HIV-infected persons. The model incorporates a feedback mechanism regulating the production of T lymphocytes and simulates the dynamics of CD8 + lymphocytes, whose production is assumed to be closely linked to that of CD4 + cells. Because CD4 + lymphocyte coun
Epidemic zoster and AIDS [letter]: Emerg Infect Dis. 1996 Oct-Dec;2(4):361-2. Unique Identifier : AIDSLINE MED/97125940; Morens DM; Agarwal AK; Sarkar S; Panda S; Detels R
Ancient Egypt and today: enough scourges to go around [letter]: Emerg Infect Dis. 1996 Oct-Dec;2(4):362-3. Unique Identifier : AIDSLINE MED/97125941; Colley DG
AIDS and AAA in Egypt? [letter]: Emerg Infect Dis. 1996 Oct-Dec;2(4):363. Unique Identifier : AIDSLINE MED/97125942; Littman RJ; Morens DM
Maternal human immunodeficiency virus infection and pregnancy outcome.: Cent Afr J Med. 1996 Aug;42(8):233-5. Unique Identifier : AIDSLINE MED/97144873; Sukwa TY; Bakketeig L; Kanyama I; Samdal HH; Tropical Disease Research Centre, Ndola, Zambia.; OBJECTIVE: A longitudinal study to determine the natural history of HIV-1 infection in pregnancy, infancy and early childhood was carried out in Ndola, Zambia . DESIGN: Prospective study. SETTING: Kabushi and Chifubu clinics. SUBJECTS: A total of 965 women attending antenatal care w
Absconding with the chaperone: essential cyclophilin-Gag interaction in HIV-1 virions.: Cell. 1996 Dec 27;87(7):1157-9. Unique Identifier : AIDSLINE MED/97134662; Luban J; Department of Microbiology, Columbia University, College of Physicians; and Surgeons, New York, New York 10032, USA.
Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid.: Cell. 1996 Dec 27;87(7):1285-94. Unique Identifier : AIDSLINE MED/97134674; Gamble TR; Vajdos FF; Yoo S; Worthylake DK; Houseweart M; Sundquist WI; Hill CP; Biochemistry Department, University of Utah, Salt Lake City 84103,; USA.; The HIV-1 capsid protein forms the conical core structure at the center of the mature virion. Capsid also binds the human peptidyl prolyl isomerase, cyclophilin A, thereby packaging the enzyme into the virion. Cyclophilin A subsequently performs an essential function in HIV-1 replication, possibly helping to disassemb
Vinca alkaloids and macrolides in human immunodeficiency virus-related malignancies: a safe association [letter]: Cancer Chemother Pharmacol. 1996;39(1-2):176-7. Unique Identifier : AIDSLINE MED/97150982; Torresin A; Cassola G; Penco G; Crisalli MP; Piersantelli N
Mother-to-infant transmission of hepatitis C virus.: Clin Invest Med. 1996 Oct;19(5):368-72. Unique Identifier : AIDSLINE MED/97044205; Chang MH; Department of Pediatrics, College of Medicine, National Taiwan; University, Taipei.; Mother-to-infant (vertical) transmission of hepatitis C virus HCV) has been documented but vertical transmission of HCV is less efficient (affecting 0% to 15% [mean 4.7%] of the infants of mothers with HCV infection) than that of hepatitis B virus. This lower rate of vertical transmission is likely due to the lower vi
[Neurophysiological studies of minamata disease with HTLV-I associated myelopathy--a case report]: Rinsho Shinkeigaku. 1996 Sep;36(9):1060-4. Unique Identifier : AIDSLINE MED/97130339; Nakanishi R; Yamanaga H; Shido T; Imamura S; Izuno Y; Ideta T; Department of Neurology, Kumamoto Kino Hospital.; In both Minamata disease (MD) and HTLV-I associated myelopathy HAM), sensory disturbance is one of the most characteristic clinical symptoms. We have examined median nerve SSEPs (MN-SEP) and posterior tibial nerve SEPs (PTN-SEP) of both patient groups, and reported their specific abnormalities. MN-SEP of MD patients n
Nonspecific airway hyperresponsiveness in HIV disease. Pulmonary Complications of HIV Infection Study Group.: Chest. 1997 Jan;111(1):121-7. Unique Identifier : AIDSLINE MED/97149197; Wallace JM; Stone GS; Browdy BL; Tashkin DP; Hopewell PC; Glassroth J; Rosen MJ; Reichman LB; Kvale PA; Department of Medicine, Olive View-UCLA Medical Center, Sylmar 91342,; USA.; OBJECTIVES: HIV disease is frequently complicated by episodic acute bronchitis, suggesting the presence of chronic bronchial inflammation. To further examine this concept, we investigated the possible association of nonspecific airway hyperresponsiveness (AHR) and HIV disease. DESIGN: Methacholine inhalation challenge
Cytomegalovirus as a primary pulmonary pathogen in AIDS.: Chest. 1997 Jan;111(1):128-34. Unique Identifier : AIDSLINE MED/97149198; Waxman AB; Goldie SJ; Brett-Smith H; Matthay RA; Department of Internal Medicine, Yale University School of Medicine,; New Haven, Conn 06520-8057, USA.; In patients with AIDS, isolation of cytomegalovirus ( CMV ) from respiratory secretions is common. It is often found with other pathogens, which has led to debate regarding its role as a primary pulmonary pathogen. A retrospect
The significance of Mycobacterium avium complex cultivation in the sputum of patients with pulmonary tuberculosis.: Chest. 1997 Jan;111(1):142-7. Unique Identifier : AIDSLINE MED/97149200; Epstein MD; Aranda CP; Bonk S; Hanna B; Rom WN; Department of Medicine, NYU Medical Center, NY 10016, USA.; Mycobacterium avium-intracellulare complex (MAC) is a ubiquitous environmental microorganism whose pathogenicity ranges from innocuous colonization to disease, in immunocompetent as well as immunocompromised individuals. We sought to determine the clinical significance of MAC in sputum cultures of patients with pulmon
Drug-resistant Mycobacterium tuberculosis and atypical mycobacteria isolated from patients with suspected pulmonary tuberculosis in Honduras.: Chest. 1997 Jan;111(1):148-53. Unique Identifier : AIDSLINE MED/97149201; Pineda-Garcia L; Ferrera A; Galvez CA; Hoffner SE; Department of Microbiology, Universidad Nacional Autonoma de Honduras,; Tegucigalpa, Honduras.; BACKGROUND: Tuberculosis is a major health problem in Central America. In Honduras , with an incidence rate of 81/100,000, it is an increasingly common cause of morbidity and hospitalization. This study was conducted to examine drug-
Lung abscess caused by Legionella micdadei.: Chest. 1997 Jan;111(1):252-3. Unique Identifier : AIDSLINE MED/97149221; Johnson KM; Huseby JS; Department of Medicine, University of Washington, Seattle, USA.; We describe a case of lung abscess caused by sporadic infection with Legionella micdadei in a patient with AIDS. L micdadei infection can be very difficult to diagnose because the organism stains only weakly Gram negative, requires special culture media, and is not detectable with some direct fluorescent antibody test
African American families and HIV/AIDS: caring for surviving children.: Child Welfare. 1997 Jan-Feb;76(1):107-25. Unique Identifier : AIDSLINE MED/97148956; Carten AJ; Fennoy I; New York University, NY, USA.; This article presents the preliminary findings of a national project undertaken to examine the medical/health, social service, and legal needs of African American children who have experienced or will experience the death of one or both parents as a result of HIV/AIDS. The project seeks to guide the development of cul
[Gene therapy--current status and outlook]: Chirurg. 1996 Oct;67(10):980-3. Unique Identifier : AIDSLINE MED/97079479; Hantzopoulos PA; Gansbacher B; Institut fur Experimentelle Chirurgie, Technischen Universitat; Munchen.; None of the human gene transfer studies to date has shown definitive proof of clinical efficacy, despite more than 100 clinical protocols involving nearly 600 patients. In spite of the lack of positive results, tremendous hope permeates the field, biotechnology companies are getting started and raising millions of dol
Case report: a rare case of chylous ascites from Mycobacterium avium intracellulare in a patient with AIDS: review of the literature.: Dig Dis Sci. 1996 Dec;41(12):2499-501. Unique Identifier : AIDSLINE MED/97148661; Rollhauser C; Borum M; Division of Gastroenterology and Nutrition, The George Washington; University Medical Center, Washington, D.C. 20037, USA.; Chylous ascites is a rare complication of acquired immunodeficiency syndrome (AIDS). Although it is most commonly associated with lymphoma, it has been reported in patients with Kaposi s sarcoma. There has been only one case reported of chyloperitoneum occurring in a pediatric patient as a result of Mycobacterium aviu
Interferon-alpha therapy for chronic hepatitis C in special patient populations.: Dig Dis Sci. 1996 Dec;41(12 Suppl):126S-130S. Unique Identifier : AIDSLINE MED/97148801; Marcellin P; Boyer N; Behamou JP; Erlinger S; Service d'Hepatologie and INSERM U24, Hopital Beaujon, Clichy, France.; Interferon-alpha therapy for chronic hepatitis C in special patient populations raises a number of issues. Patients with hemophilia, kidney disease requiring hemodialysis, mixed cryoglobulinemia, HIV infection, and those receiving an allograft share some characteristics that complicate the treatment of hepatitis C vir
Mode of hepatitis C virus infection, epidemiology, and chronicity rate in the general population and risk groups.: Dig Dis Sci. 1996 Dec;41(12 Suppl):27S-40S. Unique Identifier : AIDSLINE MED/97148787; Tillmann HL; Manns MP; Department of Gastroenterology and Hepatology, Zentrum fur Innere; Medizin und Dermatologie, Medizinische Hochschule Hannover, Germany.; Since the discovery of the hepatitis C virus (HCV), it has become evident that this infectious agent is a primary cause of posttransfusion and sporadic non-A, non-B hepatitis. Identification and introduction of surrogate markers for posttransfusion hepatitis and later introduction of anti-HCV screening has decreased t
High-dose interferon-alpha2b treatment prevents chronicity in acute hepatitis C: a pilot study.: Dig Dis Sci. 1996 Dec;41(12 Suppl):81S-85S. Unique Identifier : AIDSLINE MED/97148793; Vogel W; Graziadei I; Umlauft F; Datz C; Hackl F; Allinger S; Grunewald K; Patsch J; Department of Internal Medicine, Innsbruck University, Austria.; Acute hepatitis C takes a chronic course in 50-80% of cases. Results with interferon treatment are conflicting. To evaluate the efficacy of high-dose interferon treatment, we initiated a pilot study in 1992 using 10 MU interferon-alpha2b administered subcutaneously daily until normalization of serum transaminase conce
Potential therapeutic efficacy of Ukrain (NSC 631570) in AIDS patients with Kaposi's sarcoma.: Drugs Exp Clin Res. 1996;22(3-5):283-6. Unique Identifier : AIDSLINE MED/97055061; Voltchek IV; Liepins A; Nowicky JW; Brzosko WJ; Medical Academy of Postgraduate Studies, St. Petersburg, Russia.; In this study two case reports are presented of therapy with Ukrain, a semi-synthetic thiophosphoric acid compound of alkaloids isolated from Chelidonium majus L, for the treatment of AIDS patients with Kaposi s sarcoma. Ukrain was injected i.v. in the dose of 5 mg every other day for a total of 10 injections. During
Mitogenic properties of Ukrain (NSC-6315170) on human peripheral blood monocytes: clinical implications.: Drugs Exp Clin Res. 1996;22(3-5):99-101. Unique Identifier : AIDSLINE MED/97055023; Jin YM; Nowicky JW; Liepins A; Faculty of Medicine, Memorial University of Newfoundland, St. John's,; Canada.; Using a cell-proliferation assay, the authors examined and compared the mitogenic effects of Ukrain and phytohaemagglutinin PHA) on human peripheral blood mononuclear cells (PBMCs), as well as their synergic effects. It was found that even a short period of pretreatment of the cell with Ukrain had a potent synergic ef
Prevalence of human immunodeficiency virus infection: its impact on the diagnostic yields in exudative pleural effusions at the Kenyatta National Hospital, Nairobi.: East Afr Med J. 1996 Sep;73(9):575-8. Unique Identifier : AIDSLINE MED/97145682; Owino EA; McLigeyo SO; Gathua SN; Nyong'o A; Department of Medicine, College of Health Sciences, University of; Nairobi, Kenya.; This was a descriptive cross-sectional study carried out at Kenyatta National Hospital (KNH), Nairobi, among consecutively admitted adult patients with exudative pleural effusions over a one year period. The aim of the study was to determine the prevalence of human immunodeficiency virus (HIV) infection in these patie
Hyperacute pneumonitis in a patient with overwhelming Strongyloides stercoralis infection.: Eur J Anaesthesiol. 1996 Sep;13(5):498-501. Unique Identifier : AIDSLINE MED/97044355; Casati A; Cornero G; Muttini S; Tresoldi M; Gallioli G; Torri G; Universita degli Studi di Milano, Servizio di Anestesia e; Rianimazione, Italy.; The case of a 64-year-old man who was admitted to hospital with fever, general deterioration and anorexia is reported. For the past 4 years, the patient had been receiving corticosteroid therapy for a chronic inflammatory demyelinating polyradiculoneuropathy. Soon after admission the patient developed respiratory insu
Detection and identification of Mycobacterium avium in the blood of AIDS patients by the polymerase chain reaction.: Eur J Clin Microbiol Infect Dis. 1996 Jul;15(7):551-5. Unique Identifier : AIDSLINE MED/97027984; De Francesco MA; Colombrita D; Pinsi G; Gargiulo F; Caligaris S; Bertelli D; Martinelli F; Gao J; Turano A; Institute of Microbiology, University of Brescia, Italy.; One hundred fifty-three blood samples from patients positive for the human immunodeficiency virus (HIV) were analyzed by polymerase chain reaction (PCR) to detect the presence of Mycobacterium avium. Samples were collected from patients who also had blood cultures performed by a radiometric method. Blood samples were
Results of a double-blind placebo-controlled study of the double-stranded RNA drug polyI:polyC12U in the treatment of HIV infection.: Eur J Clin Microbiol Infect Dis. 1996 Jul;15(7):580-7. Unique Identifier : AIDSLINE MED/97027989; Thompson KA; Strayer DR; Salvato PD; Thompson CE; Klimas N; Molavi A; Hamill AK; Zheng Z; Ventura D; Carter WA; Hemispherx Biopharma Incorporated, Philadelphia, Pennsylvania 19103,; USA.; In this multicenter, randomized, double-blind study the activity of polyI:polyC12U administered with zidovudine was evaluated in the treatment of HIV infection. Thirty-six HIV-positive, pre-AIDS individuals (100-500 CD4+ cells/mm3) who had had at least six months of zidovudine therapy received polyI:polyC12U (400 or 7
Serologic responses to Rhodococcus equi in individuals with and without human immunodeficiency virus infection.: Eur J Clin Microbiol Infect Dis. 1996 Jul;15(7):588-94. Unique Identifier : AIDSLINE MED/97027990; Vullo V; Mastroianni CM; Lichtner M; Mengoni F; Chiappini E; D'Agostino C; Delia S; Department of Infectious and Tropical Diseases, La Sapienza; University, Policlinico Umberto I, Rome, Italy.; Thirty healthy blood donors, 15 workers from horse-breeding farms, 69 human immunodeficiency virus (HIV)-negative persons at risk for HIV infection, 125 HIV-infected subjects without Rhodococcus equi infection, and nine HIV-infected patients with Rhodococcus equi pneumonia were evaluated in order to detect serum antib
Nonsurgical cure of isolated cerebral mucormycosis in an intravenous drug user.: Eur J Clin Microbiol Infect Dis. 1996 Jul;15(7):598-9. Unique Identifier : AIDSLINE MED/97027992; Blazquez R; Pinedo A; Cosin J; Miralles P; Lacruz C; Bouza E; Clinical Microbiology and Infectious Diseases Division, Hospital; General Universitario Gregorio Maranon, Madrid, Spain.; The case of a 30-year-old, female, HIV-positive intravenous drug user who suffered from isolated cerebral mucormycosis is reported. Treatment with amphotericin B at an accumulative dose of 5.5 grams led to significant recovery, and there was no recurrence of disease over a follow-up period of six months. Patients with
Molecular determinants of human immunodeficiency virus type I phenotype variability.: Eur J Clin Invest. 1996 Mar;26(3):175-85. Unique Identifier : AIDSLINE MED/97060024; Fouchier RA; Schuitemaker H; Department of Clinical Viro-Immunology, Central Laboratory of the; Netherlands Red Cross Blood Transfusion Service, Amsterdam, The; Netherlands.; The clinical course of HIV-1-infected individuals can be highly variable. Progression to AIDS can occur within 1 year after infection but symptom-free infection for more than 15 years has also been reported. This variation can either be determined by host factors, the biological variability of the virus or both. Here
Effect of N-acetylcysteine(NAC) treatment on HIV-1 infection: a double-blind placebo-controlled trial.: Eur J Clin Pharmacol. 1996;50(6):457-61. Unique Identifier : AIDSLINE MED/97011261; Akerlund B; Jarstrand C; Lindeke B; Sonnerborg A; Akerblad AC; Rasool O; Department of Infectious Diseases, Karolinska Institute, Huddinge; Hospital, Sweden.; OBJECTIVE: In a double-blind placebo-controlled trial, human immunodeficiency virus (HIV)-seropositive patients with a CD4 lymphocyte cell count of more than 200 x 10(6) . l-1 were randomised to receive either 800 mg N-acetylcysteine (NAC) or placebo for 4 months. Before treatment low plasma cysteine levels, high free
Homeostatic regulation of CD8+ T cells after antigen challenge in the absence of Fas (CD95).: Eur J Immunol. 1996 Dec;26(12):2903-10. Unique Identifier : AIDSLINE MED/97131810; Zimmermann C; Rawiel M; Blaser C; Kaufmann M; Pircher H; Institute for Medical Microbiology and Hygiene, Department of; Immunology, University of Freiburg, Germany.; The role of Fas in the homeostatic regulation of CD8+ T cells after antigen challenge was analyzed in the murine model of lymphocytic choriomeningitis virus (LCMV) infection. Mice homozygous for the lpr mutation and carrying T cell receptor TCR) alphabeta transgenes specific for the LCMV glycoprotein peptide aa 33-41
Human antibodies from phage libraries: neutralizing activity against human immunodeficiency virus type 1 equally improved after expression as Fab and IgG in mammalian cells.: Eur J Immunol. 1996 Dec;26(12):3029-34. Unique Identifier : AIDSLINE MED/97131826; Samuelsson A; Yari F; Hinkula J; Ersoy O; Norrby E; Persson MA; Karolinska Institute, Department of Medicine, Stockholm, Sweden.; Human antibodies against HIV-1 have been sought to study neutralization events on the molecular level, and for possible use in passive immune intervention. The development of phage display techniques has opened the possibility of rapidly generating human monoclonal antibodies with desired specificities. We and others
Cell division in the compartment of naive and memory T lymphocytes.: Eur J Immunol. 1996 Dec;26(12):3179-84. Unique Identifier : AIDSLINE MED/97131846; Bruno L; von Boehmer H; Kirberg J; Basel Institute for Immunology, Switzerland.; Expression of activation markers and proliferative status were measured in peripheral CD4+ and CD8+ T cells of various T cell receptor (TCR)-transgenic mice either before or after intentional antigenic stimulation. In the absence of intentional immunization, CD4+ T cells persisted as resting or partially activated and
Intranuclear redistribution of SV40T, p53, and PML in a conditionally SV40T-immortalized cell line.: Exp Cell Res. 1996 Dec 15;229(2):289-300. Unique Identifier : AIDSLINE MED/97141415; Jiang WQ; Szekely L; Klein G; Ringertz N; Department of Cell and Molecular Biology, Karolinska Institutet,; Stockholm, 171 77, Sweden.; We have previously reported that EBNA-5, one of the Epstein-Barr virus-encoded proteins, accumulates in the nuclear bodies containing PML, the promyelocytic leukemia associated protein. In this study, we examine the intranuclear distribution of SV40 large T-antigen (SV40T), the p53 tumor suppressor protein (p53), and
Child-care practices: effects of social change on the epidemiology of infectious diseases and antibiotic resistance.: Epidemiol Rev. 1996;18(1):10-28. Unique Identifier : AIDSLINE MED/97031403; Holmes SJ; Morrow AL; Pickering LK; Department of Pediatrics, Children's Hospital of The King's Daughters,; Eastern Virginia Medical School, Norfolk, USA.; The increasing number of mothers of young children in the work force and the resultant escalated use of child-care facilities has had a marked effect on the epidemiology of infectious diseases in young children. Children attending child care are at high risk for respiratory and gastrointestinal tract illnesses. The hi
Tuberculosis control: the relevance of classic principles in an era of acquired immunodeficiency syndrome and multidrug resistance.: Epidemiol Rev. 1996;18(1):52-63. Unique Identifier : AIDSLINE MED/97031405; Kaye K; Frieden TR; Bureau of Tuberculosis Control, New York City Department of Health,; New York, NY 10013, USA.
Molecular epidemiology: applications of nucleic acid amplification and sequence analysis.: Epidemiol Rev. 1996;18(1):90-7. Unique Identifier : AIDSLINE MED/97031408; McDade JE; Anderson BE; National Center for Infectious Diseases, Centers for Disease Control; and Prevention, Public Health Service, US Department of Health and; Human Services, Atlanta, GA 30333, USA.
The catalytic domain of human immunodeficiency virus integrase: ordered active site in the F185H mutant.: FEBS Lett. 1996 Dec 2;398(2-3):175-8. Unique Identifier : AIDSLINE MED/97131590; Bujacz G; Alexandratos J; Qing ZL; Clement-Mella C; Wlodawer A; Macromolecular Structure Laboratory, NCI-Frederick Cancer Research and; Development Center, Frederick, MD 21702, USA.; We solved the structure and traced the complete active site of the catalytic domain of the human immunodeficiency virus type 1 integrase (HIV-1 IN) with the F185H mutation. The only previously available crystal structure, the F185K mutant of this domain, lacks one of the catalytically important residues, E152, located
The legal regulation of nursing practice.: Fla Nurse. 1996 Sep;44(8):10. Unique Identifier : AIDSLINE MED/97158353; Pallentino J
Development of CD4 and CD8 single positive T cells in human thymus organ culture: IL-7 promotes human T cell production by supporting immature T cells.: Dev Comp Immunol. 1996 Jul-Aug;20(4):241-63. Unique Identifier : AIDSLINE MED/97072862; Yeoman H; Clark DR; DeLuca D; Department of Microbiology and Immunology, University of Arizona,; Tucson 85721, USA.; This paper describes novel model systems to study the development of human T cells. Fragments of neonatal human thymus (HUNT) can be cultured in vitro; the initial majority population of CD4, CD8 double-positive (DP) thymocytes is not maintained in organ culture. These cells are rapidly replaced by populations of CD4
Bacterial vaginosis and associated infections in pregnancy.: Int J Gynaecol Obstet. 1996 Oct;55(1):23-8. Unique Identifier : AIDSLINE MED/97066597; Govender L; Hoosen AA; Moodley J; Moodley P; Sturm AW; Department of Obstetrics and Gynaecology, Faculty of Medicine,; University of Natal, Congella, South Africa.; OBJECTIVE: To assess the role of bacterial vaginosis (BV) on pregnancy complications in a developing community where mixed cervico-vaginal infections are common. SETTING: The antenatal clinic at King Edward VIII Hospital (KEH), Durban, South Africa , which is a large urban tertiary
Retinoids for vulvar dysplasia in the HIV-infected patient.: Int J Gynaecol Obstet. 1996 Oct;55(1):77-8. Unique Identifier : AIDSLINE MED/97066608; Del Priore G; Herron MM; Division of Gynecologic Oncology, New York University School of; Medicine, USA. gyn.oncology@ccmail.med.nyu.edu
[Epidemic of AIDS in Mexico. Global analysis 1981-1996]: Gac Med Mex. 1996 Sep-Oct;132(5):545-50. Unique Identifier : AIDSLINE MED/97134076; Magis-Rodr~iguez C; Loo-Mendez E; del Rio-Chiriboga C; CONASIDA (Consejo Nacional de Prevencion y control del SIDA),; Secretaria de Salud, Mexico.
[HIV prevention after needlestick injury: preventive possibilities not proven, but likely. Official recommendations are still unavailable]: Fortschr Med. 1996 Oct 10;114(28):16, 18. Unique Identifier : AIDSLINE MED/97080103; Schweiger A
Epstein-Barr virus in tumours.: Histopathology. 1996 Oct;29(4):297-315. Unique Identifier : AIDSLINE MED/97066557; Anagnostopoulos I; Hummel M; Institute of Pathology, Benjamin Franklin University Hospital, Free; University of Berlin, Germany.; The Epstein-Barr virus (EBV) is the best characterized human virus known to infect most people all over the world. In most cases, primary infection with EBV is asymptomatic and the virus persists life-long without causing any disease. The availability of sensitive detection methods, however has led to the identificati
Expression of adhesion molecules in endemic and epidemic Kaposi's sarcoma.: Histopathology. 1996 Oct;29(4):337-46. Unique Identifier : AIDSLINE MED/97066560; Kaaya EE; Castanos-Velez E; Amir H; Lema L; Luande J; Kitinya J; Patarroyo M; Biberfeld P; Department of Pathology, Karolinska Hospital/Institute, Stockholm,; Sweden.; Spindle cells and vascular endothelium in nodular lesions of AIDS associated (epidemic) and endemic Kaposi s sarcoma showed similar immunohistochemical patterns of expression for cell adhesion molecules and extracellular matrix proteins. Spindle cells as well as endothelium also expressed both alpha 5 and alpha V inte
Reactivity and specificity of CD8+ T cells in mice with defects in the MHC class I antigen-presenting pathway.: Immunol Rev. 1996 Jun;151:123-48. Unique Identifier : AIDSLINE MED/97026309; Ljunggren HG; Glas R; Sandberg JK; Karre K; Microbiology and Tumor Biology Center, Karolinska Institute,; Stockholm, Sweden.
Regulation of antigen processing and presentation to class I MHC restricted CD8+ T lymphocytes.: Immunol Rev. 1996 Jun;151:31-49. Unique Identifier : AIDSLINE MED/97026305; Hahn YS; Yang B; Braciale TJ; Beirne Carter Center for Immunology Research, University of Virginia; Health Sciences Center, Charlottesville 22908, USA.
Expression of activation-related molecules on regional lymph node lymphocytes in human lung cancer.: Immunobiology. 1996 Jul;195(2):140-51. Unique Identifier : AIDSLINE MED/97031466; Takenoyama M; Yasumoto K; Harada M; Matsuzaki G; Ishida T; Sugimachi K; Nomoto K; Department of Immunology, Medical Institute of Bioregulation, Japan.; Using two- and three-color flow cytometry, we investigated the surface makers of regional lymph node lymphocytes (RLNL) in 54 patients with primary lung cancer in order to determine whether or not RLNL are in an activation state when compared with the corresponding peripheral blood lymphocytes (PBL) for the purpose of
The opposite effect of tumor-infiltrating natural killer cells on in vivo priming of tumor-specific CD8+ T cells and CD4+ T cells.: Immunobiology. 1996 Jul;195(2):172-86. Unique Identifier : AIDSLINE MED/97031469; Terao H; Harada M; Kurosawa S; Shinomiya Y; Ito O; Tamada K; Takenoyama M; Nomoto K; Department of Immunology, Kyushu University, Fukuoka, Japan.; Natural killer (NK) cells, which infiltrated the tumor site, were examined for their effects on the in vivo priming of tumor-specific CD8+ and CD4+ T cells. CD8+ T cells were responsible for the activity of B16 melanoma-specific cytotoxic T lymphocytes (CTL). The in vivo depletion of NK cells with anti-NK1.1 monoclona
Leishmania major infection in major histocompatibility complex class II-deficient mice: CD8+ T cells do not mediate a protective immune response.: Immunobiology. 1996 Jul;195(2):243-60. Unique Identifier : AIDSLINE MED/97031475; Erb K; Blank C; Ritter U; Bluethmann H; Moll H; In order to evaluate the role of CD8+ T cells in cutaneous leishmaniasis, major histocompatibility complex (MHC) class II-deficient mice of C57BL/6 background lacking functional CD4+ T cells were infected with Leishmania major. In contrast to C57BL/6 wild-type mice which are resistant to infection with L. major, these
Three regions of HIV-1 gp160 contain clusters of immunodominant CTL epitopes.: Immunol Lett. 1996 Aug;52(1):23-30. Unique Identifier : AIDSLINE MED/97031490; Shankar P; Fabry JA; Fong DM; Lieberman J; Center for Blood Research, Harvard Medical School, Boston, MA 02115,; USA.; HIV-1 infection stimulates a strong CTL response that coincides with resolution of viremia in acute infection and declines with development of opportunistic infections. Recognition of HIV gp160 by PBMC-derived T cell lines from 20 HIV-infected subjects is dominated by the response to a small number of peptide epitopes
HIV-1 epitopes exposed by hybrid hepatitis B core particles affect proliferation of peripheral blood mononuclear cells from HIV-1 positive donors.: Immunol Lett. 1996 Aug;52(1):37-44. Unique Identifier : AIDSLINE MED/97031492; Isaguliants MG; Nordlund S; Sallberg M; Smirnov VD; Ruden U; Wahren B; Swedish Institute for Infectious Disease Control, Stockholm, Sweden.; Hepatitis B virus core protein (HBc) in particulate from is a potent immunogen for the design of vaccines with a broad T-cell reactivity. Hybrid HBc proteins with N-terminal insertions of human immunodeficiency virus (HIV-1) B- and T-cell epitopes from gp41 and p34 pol, respectively, were constructed HBc hybrids forme
Plasma levels of sTNFR p75 and IL-8 in patients with HIV-1 infection.: Immunol Lett. 1996 Aug;52(1):57-60. Unique Identifier : AIDSLINE MED/97031495; Hober D; Benyoucef S; Delannoy AS; De Groote D; Ajana F; Mouton Y; Wattre P; Laboratoire de Virologie, Bat IRFPPS, CHU, Lille, France.; We determined the degree of activation of the TNF alpha system and the levels of IL-8 in HIV-1 infection. TNF alpha is one of the most potent agents for the induction of IL-8. TNF alpha may be cleared rapidly from the circulation, however soluble tumor necrosis factor receptor (sTNFR) p75 which is more stable may refl
Allelic and interlocus comparison of the PERB11 multigene family in the MHC.: Immunogenetics. 1997;45(3):209-16. Unique Identifier : AIDSLINE MED/97152410; Gaudieri S; Leelayuwat C; Townend DC; Mullberg J; Cosman D; Dawkins RL; Centre for Molecular Immunology and Instrumentation, The University of; Western Australia GPO BOX F298, Perth, Western Australia 6001.; The major histocompatibility complex (MHC) contains at least a hundred genes over 4 megabases of DNA. Within the MHC there are several new multigene families which have been recently described. PERB11 is a multigene family which occurs over the class I and central region of the MHC. Two members of the family have been
Prevalence of HIV infection in voluntary blood donors and cancer patients.: Indian J Pathol Microbiol. 1996 Jul;39(3):187-9. Unique Identifier : AIDSLINE MED/97127322; Kumar RR; Jayshree RS; Sridhar H; Department of Microbiology, Kidwai Memorial Institute of Oncology,; Bangalore.; The HIV infection pattern amongst cancer patients and voluntary blood donors was studied at an oncology centre in South India . The study period was from May 1991 to March 1994. A total of 18,260 subjects were screened for HIV infection. Of which 14,266 were voluntary blood donors an
The prevalence of transfusion transmitted diseases in renal transplant recipients.: Indian J Pathol Microbiol. 1996 Jul;39(3):191-5. Unique Identifier : AIDSLINE MED/97127323; Choudhury N; Naik S; Sharma RK; Elhence P; Ramesh V; Gupta RK; Deptt. of Transfusion Medicine, Sanjay Gandhi Post Graduate Institute; of Medical Sciences, Lucknow.; Majority of renal transplant patients have history of blood transfusion. Out of a total of 120 renal transplant patients, 20 16.6%) patients showed raised alanine aminotransferase (ALT) levels (> 45 IU) on 2 or more occasions at 2 weeks interval. This study was undertaken to estimate the risk of transfusion transmitte
Activation of intestinal intraepithelial T lymphocytes in calves infected with Cryptosporidium parvum.: Infect Immun. 1997 Jan;65(1):185-90. Unique Identifier : AIDSLINE MED/97130034; Wyatt CR; Brackett EJ; Perryman LE; Rice-Ficht AC; Brown WC; O'Rourke KI; Department of Veterinary Microbiology and Pathology, Washington State; University College of Veterinary Medicine, Pullman 99164, USA.; rwyatt@vetmed.wsu.edu; The objective of this study was to identify disease-related changes in lymphocyte populations within ileal mucosae of calves with cryptosporidiosis. Groups of five neonatal calves were orally infected at 3 days of age with 10(8) oocysts and maintained in enteric-pathogen-free conditions until clinical disease was esta
Interaction of Salmonella typhi strains with cultured human monocyte-derived macrophages.: Infect Immun. 1997 Jan;65(1):309-12. Unique Identifier : AIDSLINE MED/97130053; Sizemore DR; Elsinghorst EA; Eck LC; Branstrom AA; Hoover DL; Warren RL; Rubin FA; Department of Bacterial Diseases, Walter Reed Army Institute of; Research, Washington, D.C. 20307-5100, USA.; Human monocyte-derived macrophages (MDM) provided this laboratory with a tool to develop a primary-cell assay for evaluating the relative virulence of newly constructed Salmonella typhi carrier strains. In this study, the interaction with and survival within MDM were compared for delta aroA143-attenuated strains, wild
Algorithms for robust nonlinear regression with heteroscedastic errors.: Int J Biomed Comput. 1996 Aug;42(3):181-90. Unique Identifier : AIDSLINE MED/97050046; Tothfalusi L; Endrenyi L; Department of Pharmacology, Department of Preventive Medicine and; Biostatistics, University of Toronto, Toronto, Ontario, Canada.; Nonlinear regression algorithms were compared by Monte-Carlo simulations when the measurement error was dependent on the measured values (heteroscedasticity) and possibly contaminated with outliers. The tested leastsquares (LSQ) algorithms either required user-supplied weights to accommodate heteroscedasticity or the
CD4+ and CD8+ circulating alpha/beta T-cell repertoires are equally complex and are characterized by different levels of steady-state TCR expression.: Hum Immunol. 1996 Jun-Jul;48(1-2):52-62. Unique Identifier : AIDSLINE MED/96421956; Naumov YN; Naumova EN; Gorski J; Molecular Genetics Laboratory, Blood Research Institute, The Blood; Center of Southeastern Wisconsin, Milwaukee, USA.; The repertoire complexity of CD4+ and CD8+ T cells was measured in three healthy blood donors for a number of TCR BV gene families by TCR spectratyping. This method subdivides V family-specific PCR products based on CDR3 length. Genomic DNA was analyzed to determine the distribution of the cells bearing particular V-J
Oligoclonality of CD8+ T cells in health and disease: aging, infection, or immune regulation?: Hum Immunol. 1996 Jun-Jul;48(1-2):68-76. Unique Identifier : AIDSLINE MED/96421958; Batliwalla F; Monteiro J; Serrano D; Gregersen PK; Division of Biology and Human Genetics, North Shore University; Hospital/Cornell University Medical College, Manhasset, New York; 11030, USA.; Oligoclonality of the CD8+ T cell subset is a common and characteristic feature of the normal human peripheral T cell repertoire. These clonally expanded populations are predominantly found in a CD57+ or CD28- CD8+ T cell subset. While CD8 oligoclonality is somewhat more common in the older age group, it is also very
Skewing of the CD8+ T-cell repertoire in the lungs of patients with systemic sclerosis.: Hum Immunol. 1996 Jun-Jul;48(1-2):84-97. Unique Identifier : AIDSLINE MED/96421960; Yurovsky VV; Wigley FM; Wise RA; White B; Department of Medicine, University of Maryland School of Medicine,; Baltimore, USA.; Pulmonary parenchymal involvement in SSc is characterized by alveolitis and interstitial fibrosis, with an increased number of CD8+ T cells in BAL fluids. This study analyzed the diversity of the alphabeta T-cell repertoire in peripheral blood and BAL fluids from seven SSc patients, looking for evidence of antigen-dri
CD4-reactive antibodies in systemic lupus erythematosus.: Hum Immunol. 1996 Aug;49(1):38-48. Unique Identifier : AIDSLINE MED/96436958; Lenert P; Lenert G; Senecal JL; Louis-Charles Simard Research Center, Notre-Dame Hospital, University; of Montreal, Quebec, Canada.; An important place in the immune network is reserved for specific interactions between regulatory antibodies (Ab) and their ligands on T and B lymphocytes. Several lines of evidence indicate that the CD4 glycoprotein may be recognized by such Ab. High levels of CD4-reactive Ab occur in approximately 10-20% of HIV-infe
Targeting of Moloney murine leukemia virus gag precursor to the site of virus budding.: J Cell Biol. 1996 Dec;135(6 Pt 2):1841-52. Unique Identifier : AIDSLINE MED/97145453; Suomalainen M; Hultenby K; Garoff H; Department of Bioscience at Novum, Sweden.; Retrovirus Moloney murine leukemia virus (M-MuLV) matures by budding at the cell surface. Central to the budding process is the myristoylated viral core protein precursor Gag which, even in the absence of all other viral components, is capable of associating with the cytoplasmic leaflet of the plasma membrane and asse
Viral load, CD4 percentage, and delayed-type hypersensitivity in subjects receiving the HIV-1 immunogen and antiviral drug therapy.: J Clin Immunol. 1996 Sep;16(5):266-71. Unique Identifier : AIDSLINE MED/97041724; Moss RB; Ferre F; Levine A; Turner J; Jensen FC; Daigle AE; Richieri SP; Truckenbrod A; Trauger RJ; Carlo DJ; Salk J; Immune Response Corporation, Carlsbad, California 92008, USA.; Two trials of subjects inoculated with the inactivated, gp120-depleted HIV-1 Immunogen are reported. In one study, in which 19 subjects received ZDV and 8 subjects received ddI, treatment with the HIV-1 Immunogen did not affect the pharmacokinetic parameters of the antiviral drugs. In another study, 65 subjects who we
Development and characterization of desmoglein-3 specific T cells from patients with pemphigus vulgaris.: J Clin Invest. 1997 Jan 1;99(1):31-40. Unique Identifier : AIDSLINE MED/97148768; Lin MS; Swartz SJ; Lopez A; Ding X; Fernandez-Vina MA; Stastny P; Fairley JA; Diaz LA; Department of Dermatology, Medical College of Wisconsin, Milwaukee; 53226, USA. mslin@post.its.mcw.edu; Pemphigus vulgaris (PV) is a cutaneous autoimmune disease characterized by blister formation in the suprabasilar layers of skin and mucosae and anti-desmoglein-3 (Dsg3) autoantibodies bound to the surface of lesional keratinocytes and circulating in the serum of patients. This disease can be reproduced in neonatal mic
Papillon-Lefevre syndrome. Analysis of peripheral blood lymphocyte subsets.: J Clin Periodontol. 1996 Sep;23(9):823-5. Unique Identifier : AIDSLINE MED/97047011; Firatii E; Gurel N; Efeoglu A; Department of Periodontology, School of Dentistry, Istanbul School of; Medicine, University of Istanbul, Turkey.; We have studied the peripheral blood lymphocyte populations in our 6 patients (2 female and 4 male) with a mean age of 11.19 with Papillon-Lefevre Syndrome (PLS) using adequate monoclonal antibodies and double coloured flow cytometry. Total B, T, CD4, CD8, CD29, CD45RA, NK, HLA-DR cells were studied. Total B, T, CD4 a
Acquired immunodeficiency syndrome and suburban adolescents: knowledge, attitudes, behaviors and risks.: J Community Health. 1996 Oct;21(5):329-47. Unique Identifier : AIDSLINE MED/97050232; Imperato AM; Bryn Mawr College, PA 19010-2899, USA.; A seventy-nine question survey concerning AIDS was administered to 142 students in a high school senior class in Manhasset, Long Island, an affluent New York City suburb with a low incidence of AIDS. The instrument elicited information about knowledge, attitudes and beliefs, behaviors, and risks. Overall knowledge lev
An evaluation of community nursing services for HIV/AIDS patients in Lothian, Scotland.: J Adv Nurs. 1996 Oct;24(4):736-42. Unique Identifier : AIDSLINE MED/97050163; Atkinson FI; Grant I; Lewis R; Sherval J; Centre for HIV/AIDS & Drug Studies, City Hospital, Edinburgh,; Scotland.; This paper reports on a postal questionnaire survey of district nurses work with HIV positive patients. Each nurse was asked to provide information about their contact with HIV positive patients and the level of training they had received in HIV/AIDS care. The nature of nursing activities carried out for these patien
Health care professionals' attitudes toward lesbian women and gay men.: J Homosex. 1996;31(3):71-83. Unique Identifier : AIDSLINE MED/97050301; Schwanberg SL; College of Nursing, University of New Mexico, Albuquerque 87131-1061,; USA.; The purpose of this paper is to examine health care workers attitudes toward lesbian women and gay men before and after the AIDS epidemic. Fifty-one studies which assessed attitudes using paper and pencil instruments were examined. Attitudes were assessed using primarily cognitive and affective questions about homose
Research directions in male sex work.: J Homosex. 1996;31(4):29-56. Unique Identifier : AIDSLINE MED/97061498; Browne J; Minichiello V; Sexual Health Research Group, University of New England, Armidale, New; South Wales.; This paper provides a critical review of the literature relating to male sex work and outlines approaches to theorizing about and researching male sex work. The adequacy of these models to explain the male sex work industry is discussed. The literature reveals that earlier studies conceptualized male sex work as devia
"Why strengthen the city wall when the enemy has poisoned the well?" An assay of anti-homosexual discourse in New Zealand.: J Homosex. 1996;31(4):75-105. Unique Identifier : AIDSLINE MED/97061500; McCreanor T; Department of Psychology, University of Auckland, New Zealand.; Proposed changes to New Zealand law on homosexuality made the issues a matter of widespread public debate in the mid-1980s. The present study, which was designed as an exploratory assay of anti-homosexual discourse, draws on a large body of public submissions to the New Zealand
Impact of HIV infection on leprosy.: Indian J Lepr. 1996 Jul-Sep;68(3):255-6. Unique Identifier : AIDSLINE MED/97044541; Thappa DM; Garg BR; Rao MV; Gharami R; Department of Dermatology & STD, JIPMER, Pondicherry.
A comparison of glandular involvement between chronic graft-versus-host disease and Sjogren's syndrome.: Int J Oral Maxillofac Surg. 1996 Aug;25(4):298-307. Unique Identifier : AIDSLINE MED/97066637; Hiroki A; Nakamura S; Shinohara M; Gondo H; Ohyama Y; Hayashi S; Harada M; Niho Y; Oka M; Second Department of Oral and Maxillofacial Surgery, Faculty of; Dentistry, Kyushu University, Fukuoka, Japan.; Patients with chronic graft-versus-host disease (cGVHD) occasionally suffer from symptoms of xerostomia and xerophthalmia, which are also features of Sjogren s syndrome SS). To identify differences in the glandular involvement between cGVHD and SS, we measured the proportions of infiltrating lymphocyte subsets and the
[RalGDS mediates an intracellular signal-transduction system from a proto-oncogene product Ras]: Seikagaku. 1996 Oct;68(10):1646-50. Unique Identifier : AIDSLINE MED/97095827; Koyama S; Kishida S; Kikuchi A; Department of Biochemistry, Hiroshima University School of Medicine.
Computing marginal expectations for large compartmentalized models with application to AIDS evolution in a prison system.: IMA J Math Appl Med Biol. 1996 Dec;13(4):223-44. Unique Identifier : AIDSLINE MED/97123537; Yakowitz S; Blount M; Gani J; University of Arizona, Tucson 85721, USA.; The customary models for the AIDS epidemic are compartmentalized according to criteria such as risk factors, sexual habits, gender, race, age, and HIV status and stage. Hitherto, with very few exceptions, investigators have resorted to deterministic approximations or to simulation for the computational investigation o
Regulation of fetal allograft survival by a hormone-controlled Th1- and Th2-type cytokines.: Immunol Res. 1996;15(2):141-50. Unique Identifier : AIDSLINE MED/96436966; Piccinni MP; Romagnani S; Division of Clinical Immunology and Allergy, University of Florence,; Italy.; There is clear evidence to suggest that the maternal immune system during pregnancy can enhance or inhibit the development of the fetoplacental unit. Recent data support the view that some cytokines produced by both T cells and non-T cells (IL-3, GM-CSF, TGF-beta, IL-4, IL-10), favor fetal survival and growth. In cont
Macrophages, cytokines, and HIV.: J Lab Clin Med. 1997 Jan;129(1):10-6. Unique Identifier : AIDSLINE MED/97148718; Bornemann MA; Verhoef J; Peterson PK; Department of Internal Medicine, Hennepin County Medical Center and; the University of Minnesota Medical School, Minneapolis 55415, USA.
HIV and AIDS in Africa. African policies in response to AIDS in relation to various national legal traditions.: J Leg Med. 1996 Dec;17(4):527-46. Unique Identifier : AIDSLINE MED/97145778; Alkas PH; Shandera WX; Harris County Attorney Office, Houston, Texas, USA.
Enhancement of TAT-induced transactivation of the HIV-1 LTR by two genomic fragments of HHV-6.: J Med Virol. 1996 Sep;50(1):20-4. Unique Identifier : AIDSLINE MED/97044965; Garzino-Demo A; Chen M; Lusso P; Berneman Z; DiPaolo JA; Laboratory of Biology, National Cancer Institute Bethesda, MD 20892,; USA.; Clinical and experimental observations suggest that human herpesvirus-6 (HHV-6), a T-lymphotropic herpesvirus, may act as a cofactor in the acquired immunodeficiency syndrome (AIDS). Moreover, a possible role of HHV-6 in the increased incidence and severity of cervical carcinoma in human immunodeficiency virus HIV)-in
Viral serologies in patients with chronic fatigue and chronic fatigue syndrome.: J Med Virol. 1996 Sep;50(1):25-30. Unique Identifier : AIDSLINE MED/97044966; Buchwald D; Ashley RL; Pearlman T; Kith P; Komaroff AL; Department of Medicine, University of Washington, Seattle, USA.; Chronic fatigue syndrome (CFS) is an illness characterized by disabling fatigue associated with complaints of fevers, sore throat, myalgia, lymphadenopathy, sleep disturbances, neurocognitive difficulties, and depression. A striking feature of CFS is its sudden onset following an acute, presumably viral, illness and t
Cervicovaginal synthesis of IgG antibodies to the immunodominant 175-199 domain of the surface glycoprotein gp46 of human T-cell leukemia virus type I.: J Med Virol. 1996 Sep;50(1):42-9. Unique Identifier : AIDSLINE MED/97044969; Belec L; Georges-Courbot MC; Georges A; Mohamed AS; Londos-Gagliardi D; Hallouin MC; Hocini H; Guillemain B; Laboratory of Virology, Broussais Hospital, Paris, France.; Paired sera, saliva and cervicovaginal secretions from 17 HTLV-I-infected women (19-75 yr) were tested for total IgA and IgG, for IgA and IgG to the immunodominant region gp46/175-Pro-199, for serum IgG to the neutralizing domains gp46/ 190-Pro-199 and gp46/190-Ser-199, or for tax-rex proviral HTLV-DNA. Serum antibodi
Six lignans from Phyllanthus myrtifolius.: J Nat Prod. 1996 Nov;59(11):1061-5. Unique Identifier : AIDSLINE MED/97102239; Lee SS; Lin MT; Liu CL; Lin YY; Liu KC; School of Pharmacy, National Taiwan University, Taipei, Republic of; China.; Six lignans comprising phyllamyricins D (1), E (2), and F (3) and phyllamyricosides A (4), B (5), and C (6) were isolated in a continuing study of Phyllanthus myrtifolius. Compounds 1 and 2 are 2a-methoxy-4-aryl-2,3-naphthalides. Compounds 3-6 belong to the 4-arylnaphthalene class, with compounds 4-6 being O-beta-gluc
Two new lignans, interiotherins A and B, as anti-HIV principles from Kadsura interior.: J Nat Prod. 1996 Nov;59(11):1066-8. Unique Identifier : AIDSLINE MED/97102240; Chen DF; Zhang SX; Chen K; Zhou BN; Wang P; Cosentino LM; Lee KH; Department of Pharmacognosy, School of Pharmacy, Shanghai Medical; University, People's Republic of China.; Two new lignans, interiotherins A (1) and B (2), along with two known lignans, angeloylgomisin R (3) and schisantherin D (4), were isolated from Kadsura interior. Their structures and stereochemistries were determined from spectral data. Compounds 1 and 4 inhibit HIV replication with EC50 values of 3.1 and 0.5 microgr
Association between HIV distal symmetric polyneuropathy and Mycobacterium avium complex infection.: J Neurol Neurosurg Psychiatry. 1996 Dec;61(6):606-9. Unique Identifier : AIDSLINE MED/97126185; Norton GR; Sweeney J; Marriott D; Law MG; Brew BJ; Department of Neurology, St Vincent's Hospital, Sydney, New South; Wales, Australia.; OBJECTIVES: Pronounced infiltration of activated macrophages occurs in the peripheral nerves of patients with HIV distal symmetric polyneuropathy (DSPN). Mycobacterium avium complex MAC) is a common facultative intracellular parasite of the macrophage in advanced HIV disease and may induce macrophage activation. Wheth
Drug resistant Pseudomonas aeruginosa bacteremia in HIV-infected patients.: J Chemother. 1995 Nov;7 Suppl 4:180-3. Unique Identifier : AIDSLINE MED/97059828; Tacconelli E; Tumbarello M; Ventura G; Lucia MB; Caponera S; Cauda R; Istituto Clinica delle Malattie Infettive, Universita Cattolica Sacro; Cuore, Roma, Italy.
Impact of primary prophylaxis for Pneumocystis carinii pneumonia and toxoplasmic encephalitis in a cohort of 1000 patients with AIDS.: J Chemother. 1995 Nov;7 Suppl 4:184-6. Unique Identifier : AIDSLINE MED/97059829; Monforte AD; Mainini F; Bini T; Moscatelli GC; Antinori S; Formenti T; Testa L; Mena M; Moroni M; Clinic of Infectious Diseases, University of Milan, L Sacco Hospital,; Italy.
Atypical mycobacterium infections in AIDS: clinical and microbiological features.: J Chemother. 1995 Nov;7 Suppl 4:187-9. Unique Identifier : AIDSLINE MED/97059830; Pasticci MB; Baldelli F; D'Alo F; Moretti A; Piersimoni C; Sbaraglia G; Sposini T; Stagni G; Tascini C; Pauluzzi S; Institute of Infectious Diseases, Department of Experimental Medicine; and Biochemical Sciences, University of Perugia.
Adverse reactions to sulphonamides in patients with HIV infection.: J Chemother. 1995 Nov;7 Suppl 4:190-2. Unique Identifier : AIDSLINE MED/97059831; Federico G; Del Forno A; Del Borgo C; Ricci F; Tumbarello M; Fantoni M; Department of Infectious Disease, Catholic University, Rome, Italy.
In vitro susceptibility of mycobacterial isolates from AIDS patients.: J Chemother. 1995 Nov;7 Suppl 4:87-9. Unique Identifier : AIDSLINE MED/97059797; Scavizzi A; Baldelli F; Capparelli G; Merletti L; Pasticci MB; Polidori M; Tascini C; Sbaraglia G; Microbiology Section, Department of Experimental Medicine and; Biochemical Sciences, University of Perugia, Italy.
Virucidal activity of pure singlet oxygen generated by thermolysis of a water-soluble naphthalene endoperoxide.: J Photochem Photobiol B. 1996 Oct;36(1):23-9. Unique Identifier : AIDSLINE MED/97142490; Dewilde A; Pellieux C; Hajjam S; Wattre P; Pierlot C; Hober D; Aubry JM; Laboratoire de Bacteriologie-Virologie B. CHU de Lille, France.; Using the water-soluble naphthalene carrier of singlet oxygen NDPO2, we have shown that pure singlet oxygen is able to inactivate enveloped viruses (human immunodeficiency virus type 1, herpes simplex virus type 1, cytomegalovirus , vesicular stomatitis virus), but has no effect on
UVB irradiation-induced transcription from the long terminal repeat of intracisternal A particles and UVB-induced secretion of an extracellular factor that induces transcription of the intracisternal A particles in unirradiated cells.: J Photochem Photobiol B. 1996 Oct;36(1):61-6. Unique Identifier : AIDSLINE MED/97142493; Faure E; Emanoil-Ravier R; Champion S; Ecologie et Biologie Evolutive, Univerisite de Provence, Marseille,; France.; Intracisternal A particles (IAPs) are endogenous defective retroviral-like elements encoded by a family of proviral sequences present as a thousand copies in the mouse genome. In order to analyse the regulation of the long terminal repeat (LTR) directed transcription by UVB, D152 murine cells were transfected with a c
The effects of human seminal plasma and PGE2 on mitogen induced proliferation and cytokine production of human splenic lymphocytes and peripheral blood mononuclear cells.: J Reprod Immunol. 1996 May;30(2-3):97-114. Unique Identifier : AIDSLINE MED/96413112; Miao D; Skibinski G; James K; Department of Surgery, University of Edinburgh Medical School, UK.; The effects of human seminal plasma (HSP) and prostaglandin E2 PGE2) on the proliferative responses of human splenic lymphocytes and peripheral blood mononuclear cells (PBMCs) to phytohaemagglutinin (PHA), anti-CD3 and anti-CD3 plus anti-CD28 mAb have been studied. Th1 and Th2 cytokines were also measured in the super
A progesterone-dependent immunomodulatory protein alters the Th1/Th2 balance.: J Reprod Immunol. 1996 Aug;31(1-2):81-95. Unique Identifier : AIDSLINE MED/97041853; Szekeres-Bartho J; Wegmann TG; Department of Microbiology, University Medical School, Pecs, Hungary.; In the presence of progesterone, lymphocytes from pregnant females produce an immunomodulatory protein known as progesterone induced blocking factor (PIBF). We tested the effect of this protein on cytokine production by mitogen-activated lymphocytes. Spleen cells from Balb/c mice were incubated with Con A in the prese
Nonhuman Primate Models for AIDS VIII. Proceedings of a meeting. Monterey, California, November 5-8, 1995.: J Med Primatol. 1996 Jun;25(3):147-250. Unique Identifier : AIDSLINE MED/97163318
The history of simian AIDS.: J Med Primatol. 1996 Jun;25(3):148-57. Unique Identifier : AIDSLINE MED/97047115; Gardner MB; University of California, School of Medicine, Department of Medical; Pathology, Davis 95616, USA.; Retrospective data indicate that two separate outbreaks of simian AIDS and associated lymphoma were caused by Simian Immunodeficiency Virus (SIVmac and SIVstm, respectively) in group-housed macaques at the California Regional Primate Research Center (CRPRC) in the early and mid-1970s. Because these epizootics were not
Do cytotoxic T lymphocytes clear some HIV/SIV infections?: J Med Primatol. 1996 Jun;25(3):158-62. Unique Identifier : AIDSLINE MED/97047116; Ada G; Division of Immunology and Cell Biology, John Curtin School of Medical; Research, Australian National University, Canberra.; Early work on the roles of cytotoxic T lymphocytes (CTLs) in acute viral infections in animal models showed that i) the clearance of virus coincided with the increase in CTL activity rather than specific antibody levels, ii) transfer of CTLs after infection could protect from a lethal dose of virus, and iii) in primed
The value of primate models for studying human immunodeficiency virus pathogenesis.: J Med Primatol. 1996 Jun;25(3):163-74. Unique Identifier : AIDSLINE MED/97047117; Levy JA; Department of Medicine, University of California, School of Medicine,; San Francisco 94143-1270, USA.; Research on human immunodeficiency virus (HIV) infection is compromised by the obvious limitation in having for study only virus-infected individuals or those exposed to the virus. Steps involved in transmission or pathogenesis require planned experimentation. The identification of animal models of acquired immunodefi
Initial characterization of viral sequences from a SHIV-inoculated pig-tailed macaque that developed AIDS.: J Med Primatol. 1996 Jun;25(3):175-85. Unique Identifier : AIDSLINE MED/97047118; Stephens EB; Joag SV; Sheffer D; Liu ZQ; Zhao L; Mukherjee S; Foresman L; Adany I; Li Z; Pinson D; Narayan O; Department of Microbiology, Molecular Genetics and Immunology, Marion; Merrell Dow Laboratory of Viral Pathogenesis, University of Kansas; Medical Center, Kansas City 66160-7240, USA.; In this study, we report on the derivation of a pathogenic SIV-HIV chimeric virus (SHIV) and the initial characterization of the viral sequences from the first (macaque PPc) of a series of pig-tailed macaques that developed CD4+ T cell loss and AIDS. Viral genes were amplified by PCR from the brain, lymphoid, and kidn
The immunopathogenesis of retroviral diseases: no immunophenotypic alterations in T, B, and NK cell subsets in SIVmac239-challenged rhesus macaques protected by SIV delta nef vaccination.: J Med Primatol. 1996 Jun;25(3):186-91. Unique Identifier : AIDSLINE MED/97047119; Giorgi JV; Hultin LE; Desrosiers RC; Department of Medicine, UCLA School of Medicine 90095-1745, USA.; Immunophenotype analysis was used to characterize circulating lymphocyte subset levels in both rhesus monkeys that were chronically infected with SIVmac239 and in those that had resisted SIVmac239 infection as a result of prior vaccination with an attenuated SIV strain. Alterations in T, NK, and B cell subsets were co
In vitro T lymphopoiesis: a model system for stem cell gene therapy for AIDS.: J Med Primatol. 1996 Jun;25(3):192-200. Unique Identifier : AIDSLINE MED/97047120; Rosenzweig M; Marks DF; Hempel D; Johnson RP; Division of Immunology, New England Regional Primate Research Center,; Harvard Medical School, Southborough, MA 01772, USA.; Stable introduction of therapeutic genes into hematopoietic stem cells has the potential to reconstitute immunity in individuals with HIV infection. However, many important questions regarding the safety and efficacy of this approach remain unanswered and may be addressed in a non-human primate model. To facilitate ev
Immunodeficiency virus cDNA synthesis in resting T lymphocytes is regulated by T cell activation signals and dendritic cells.: J Med Primatol. 1996 Jun;25(3):201-9. Unique Identifier : AIDSLINE MED/97047121; Polacino PS; Pinchuk LM; Sidorenko SP; Clark EA; Washington Regional Primate Research Center, University of Washington,; Seattle 98195, USA.; We explored the relationship between T cell activation signals and dendritic cells (DC) in the replication cycle of immunodeficiency viruses. First we analyzed the effect of two cell cycle inhibitors (mimosine and aphidicolin) on SIV reverse transcription, circularization, and integration in macaque resting T cells st
Detection of intracellular signal transduction molecules in PBMC from rhesus macaques and sooty mangabeys.: J Med Primatol. 1996 Jun;25(3):210-7. Unique Identifier : AIDSLINE MED/97047122; Brice GT; Villinger F; Mayne A; Sundstrom JB; Ansari AA; Department of Pathology and Laboratory Medicine, Emory University; School of Medicine, Atlanta, GA, USA.; One of the manifestations of human HIV-1 and nonhuman primate SIV infection that lead to disease is reasoned to be secondary to generalized T-cell dysfunction. The molecular mechanisms associated with the T-cell dysfunction remain to be elucidated. To address this issue, we sought to utilize the nonhuman primate model
Development of a chronically catheterized maternal-fetal macaque model to study in utero mother-to-fetus HIV transmission: a preliminary report.: J Med Primatol. 1996 Jun;25(3):218-24. Unique Identifier : AIDSLINE MED/97047123; Ho RJ; Agy MB; Morton WR; Scheibel M; McClure J; Watson A; Hu SL; Nosbisch C; Dorofeeva N; Unadkat JD; Department of Pharmaceutics, University of Washington, Seattle; 98195-7610, USA.; The lack of a representative animal model that permits frequent in utero fetal blood sampling is a major limiting factor for the study of maternal-fetal HIV transmission. Therefore, we have developed a maternal-fetal virus infection model using chronically catheterized macaques to simultaneously study the time-course
Genotypic analysis of infant macaques infected transplacentally and orally.: J Med Primatol. 1996 Jun;25(3):225-35. Unique Identifier : AIDSLINE MED/97047124; Martin Amedee A; Lacour N; Martin LN; Clements JE; Bohm RB Jr; Davison B; Harrison R; Murphey-Corb M; Tulane Regional Primate Research Center, Covington, LA 70433, USA.; The SIV-infected macaque provides an excellent model to study factors involved in maternal-fetal transmission of HIV. In our prenatal transmission studies, female macaques were inoculated intravenously during midgestation with either SIV/DeltaB670 or a combination of SIV/ DeltaB670 and the macrophage-tropic molecular
Induction of immunodeficiency virus-specific immune responses in rhesus monkeys following gene gun-mediated DNA vaccination.: J Med Primatol. 1996 Jun;25(3):236-41. Unique Identifier : AIDSLINE MED/97047125; Fuller DH; Murphey-Corb M; Clements J; Barnett S; Haynes JR; Auragen, Inc., Middleton, WI, USA.; The Accell gene delivery system (gene gun) was used to deliver gold particles coated with HIV-1LAI and SIVmac239 expression constructs into the epidermis of rhesus macaques, resulting in the elicitation of env- and gag-specific humoral responses. One microgram of vector DNA per dose was sufficient to induce immune res
In vivo protective anti-HIV immune responses in non-human primates through DNA immunization.: J Med Primatol. 1996 Jun;25(3):242-50. Unique Identifier : AIDSLINE MED/97047126; Boyer JD; Wang B; Ugen KE; Agadjanyan M; Javadian A; Frost P; Dang K; Carrano RA; Ciccarelli R; Coney L; Williams WV; Weiner DB; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia 19104, USA.; An effective immune response involves the specific recognition of and elimination of an infectious organism at multiple levels. In this context DNA immunization can present functional antigenic proteins to the host for recognition by all arms of the immune system, yet provides the opportunity to delete any genes of th
Teen sex, AIDS, and contraception: Part three [editorial]: J Natl Med Assoc. 1996 Dec;88(12):768-72. Unique Identifier : AIDSLINE MED/97145131; Dawson G
Serum beta-carotene deficiency in HIV-infected children.: J Natl Med Assoc. 1996 Dec;88(12):789-93. Unique Identifier : AIDSLINE MED/97145134; Omene JA; Easington CR; Glew RH; Prosper M; Ledlie S; Department of Ambulatory Care, Woodhull Medical and Mental Health; Center, Brooklyn, New York 11206, USA.; Representative levels of serum micronutrients specifically, beta-carotene and vitamins A and E, were studied in symptomatic human immunodeficiency virus (HIV)-infected children. The nutritional status of 23 symptomatic African-American and Hispanic HIV-infected children were compared with an appropriate control group
Clinical data sets of human immunodeficiency virus type 1 reverse transcriptase-resistant mutants explained by a mathematical model.: J Virol. 1997 Jan;71(1):161-8. Unique Identifier : AIDSLINE MED/97138309; Stilianakis NI; Boucher CA; De Jong MD; Van Leeuwen R; Schuurman R; De Boer RJ; Theoretical Division, Group T-10, Los Alamos National Laboratory, Los; Alamos, New Mexico 87545, USA.; Treatment of human immunodeficiency virus type 1 (HIV-1) infection during the clinical latency phase with drugs inhibiting reverse transcriptase (RT) reduces the HIV-1 RNA load and increases the CD4+ T-cell count. Typically, however, the virus evolves mutations in the RT gene that circumvent the drugs. We develop a ma
Identification of a sequence within U5 required for human immunodeficiency virus type 1 to stably maintain a primer binding site complementary to tRNA(Met).: J Virol. 1997 Jan;71(1):207-17. Unique Identifier : AIDSLINE MED/97138314; Kang SM; Zhang Z; Morrow CD; Department of Microbiology, University of Alabama at Birmingham,; 35294, USA.; Initiation of reverse transcription of human immunodeficiency virus type 1 (HIV-1) occurs by extension from the 3 end of a cellular tRNA complexed to the primer binding site (PBS) located near the 5 end of the viral RNA genome. Although the PBSs for all naturally occurring HIV-1 viruses are complementary to the 3 -t
A novel human T-leukemia virus type 1 cell-to-cell transmission assay permits definition of SU glycoprotein amino acids important for infectivity.: J Virol. 1997 Jan;71(1):259-66. Unique Identifier : AIDSLINE MED/97138319; Delamarre L; Rosenberg AR; Pique C; Pham D; Dokhelar MC; URA 1156 CNRS, Institut Gustave Roussy, Villejuif, France.; Human T-leukemia virus type 1 (HTLV-1) envelope glycoproteins play a major role in viral transmission, which in the case of this virus occurs almost exclusively via cell-to-cell contact. Until very recently, the lack of an HTLV-1 infectivity assay precluded the determination of the HTLV-1 protein domains required for
Plasma viremia in macaques infected with simian immunodeficiency virus: plasma viral load early in infection predicts survival.: J Virol. 1997 Jan;71(1):284-90. Unique Identifier : AIDSLINE MED/97138322; Watson A; Ranchalis J; Travis B; McClure J; Sutton W; Johnson PR; Hu SL; Haigwood NL; Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle,; Washington 98121, USA. Andrew_J._Watson@ccmail.bms.com; A reliable method for the quantitation of plasma viremia in nonhuman primates infected with simian immunodeficiency virus SIV) and related viruses is described. This method is based on an established quantitative-competitive PCR format and includes a truncated control for internal assay calibration. Optimization of as
Genetic diversity of simian immunodeficiency viruses from West African green monkeys: evidence of multiple genotypes within populations from the same geographical locale.: J Virol. 1997 Jan;71(1):307-13. Unique Identifier : AIDSLINE MED/97138325; Bibollet-Ruche F; Brengues C; Galat-Luong A; Galat G; Pourrut X; Vidal N; Veas F; Durand JP; Cuny G; Laboratoire Retrovirus, ORSTOM, Montpellier, France.; bibollet@infobiogen.fr; High simian immunodeficiency virus (SIV) seroprevalence rates have been reported in the different African green monkey (AGM) subspecies. Genetic diversity of these viruses far exceeds the diversity observed in the other lentivirus-infected human and nonhuman primates and is thought to reflect ancient introduction of S
Selective switch between latency and lytic replication of Kaposi's sarcoma herpesvirus and Epstein-Barr virus in dually infected body cavity lymphoma cells.: J Virol. 1997 Jan;71(1):314-24. Unique Identifier : AIDSLINE MED/97138326; Miller G; Heston L; Grogan E; Gradoville L; Rigsby M; Sun R; Shedd D; Kushnaryov VM; Grossberg S; Chang Y; Yale University School of Medicine, New Haven, Connecticut 06520, USA.; George_Miller@qm.yale.edu; The BC-1 cell line, derived from a body cavity-based, B-cell lymphoma, is dually infected with Epstein-Barr virus (EBV) and Kaposi s sarcoma-associated herpesvirus (KSHV). In these studies, the relationships between these two gammaherpesviruses and BC-1 cells were characterized and compared. Single-cell cloning experi
Function of the human T-cell leukemia virus type 1 21-base-pair repeats in basal transcription.: J Virol. 1997 Jan;71(1):337-44. Unique Identifier : AIDSLINE MED/97138329; Barnhart MK; Connor LM; Marriott SJ; Division of Molecular Virology, Baylor College of Medicine, Houston,; Texas 77030, USA.; The human T-cell leukemia virus type 1 (HTLV-1) promoter contains three copies of an imperfect 21-bp repeat called Tax-responsive element (TRE1). To examine the role of individual TRE1 sequences in basal transcription of the HTLV-1 promoter, site-directed mutations were generated in all possible combinations of one, t
The vesicular stomatitis virus matrix protein inhibits transcription from the human beta interferon promoter.: J Virol. 1997 Jan;71(1):371-7. Unique Identifier : AIDSLINE MED/97138333; Ferran MC; Lucas-Lenard JM; Department of Molecular and Cell Biology, University of Connecticut,; Storrs 06269-3125, USA.; In cells infected by wild-type (wt) vesicular stomatitis virus VSV) Indiana, host transcription is severely inhibited. DNA cotransfection studies have implicated the VSV matrix (M) protein in this process (B. L. Black and D. S. Lyles, J. Virol. 66:4058-4064, 1992). The M protein inhibited transcription not only from v
Analysis of cleavage site mutations between the NC and PR Gag domains of Rous sarcoma virus.: J Virol. 1997 Jan;71(1):444-50. Unique Identifier : AIDSLINE MED/97138343; Schatz G; Pichova I; Vogt VM; Section of Biochemistry, Molecular and Cell Biology, Cornell; University, Ithaca, New York 14853, USA.; In retroviruses, the viral protease (PR) is released as a mature protein by cleavage of Gag, Gag-Pro, or Gag-Pro-Pol precursor polypeptides. In avian sarcoma and leukemia viruses (ASLV), PR forms the C-terminal domain of Gag. Based on the properties of a mutation (cs22) in the cleavage site between the upstream NC dom
Tethering human immunodeficiency virus type 1 preintegration complexes to target DNA promotes integration at nearby sites.: J Virol. 1997 Jan;71(1):458-64. Unique Identifier : AIDSLINE MED/97138345; Bushman FD; Miller MD; Infectious Disease Laboratory, Salk Institute for Biological Studies,; La Jolla, California 92037, USA.; Integration of retroviral cDNA in vivo is normally not sequence specific with respect to the integration target DNA. We have been investigating methods for directing the integration of retroviral DNA to predetermined sites, with the dual goal of understanding potential mechanisms governing normal site selection and de
Productive and lytic infection of human CD4+ type 1 helper T cells with macrophage-tropic human immunodeficiency virus type 1.: J Virol. 1997 Jan;71(1):465-70. Unique Identifier : AIDSLINE MED/97138346; Tanaka Y; Koyanagi Y; Tanaka R; Kumazawa Y; Nishimura T; Yamamoto N; Department of Biosciences, School of Science, Kitasato University,; Sagamihara, Kanagawa, Japan.; It is generally recognized that macrophage-tropic human immunodeficiency virus type 1 (HIV-1) is the predominant population during the acute and asymptomatic phases of HIV-1 infection. Here, we compared the proliferation and syncytium-inducing activities of different HIV-1 strains in primary CD4+ T cells expressing va
Evidence for CD8+ T-cell immunity to murine rotavirus in the absence of perforin, fas, and gamma interferon.: J Virol. 1997 Jan;71(1):479-86. Unique Identifier : AIDSLINE MED/97138348; Franco MA; Tin C; Rott LS; VanCott JL; McGhee JR; Greenberg HB; Department of Medicine, Stanford University School of Medicine,; California 94305, USA. francoma@leland.stanford.edu; We recently showed that class I-restricted CD8+ T cells mediate clearance of primary rotavirus infection in mice: JHD knockout JHD /-) (B-cell-deficient) mice depleted of CD8+ T cells become chronically infected with murine rotavirus, and beta2 microglobulin knockout (beta2m -/-) mice have delayed but complete clearan
Trypsin-sensitive and -resistant components in human T-cell membranes required for syncytium formation by human T-cell lymphotropic virus type 1-bearing cells.: J Virol. 1997 Jan;71(1):601-7. Unique Identifier : AIDSLINE MED/97138363; Sagara Y; Ishida C; Inoue Y; Shiraki H; Maeda Y; Fukuoka Red Cross Blood Center, Chikushino, Japan.; Human T-cell lymphotropic virus type 1 (HTLV-1) envelope proteins play an important role in viral entry into target cells. In a syncytium formation assay consisting of a coculture of HTLV-1-bearing cells and target cells, mature gp46 and gp21 proteins each inhibited syncytium formation induced by HTLV-1-bearing cells.
Both wild-type and strongly attenuated bovine leukemia viruses protect peripheral blood mononuclear cells from apoptosis.: J Virol. 1997 Jan;71(1):630-9. Unique Identifier : AIDSLINE MED/97138367; Dequiedt F; Hanon E; Kerkhofs P; Pastoret PP; Portetelle D; Burny A; Kettmann R; Willems L; Department of Molecular Biology and Animal Physiology, Faculty of; Agronomy, Gembloux, Belgium.; Bovine leukemia virus (BLV) and the human T-cell leukemia viruses belong to the same subfamily of oncoviruses. Although much attention has focused on the mechanisms of cell proliferation and transformation by these viruses, experiments on the apoptotic process have yielded conflicting data in in vitro cell culture. Ex
Human immunodeficiency virus type 1 genetic evolution in children with different rates of development of disease.: J Virol. 1997 Jan;71(1):663-77. Unique Identifier : AIDSLINE MED/97138372; Ganeshan S; Dickover RE; Korber BT; Bryson YJ; Wolinsky SM; Department of Medicine, Northwestern University Medical School,; Chicago, Illinois 60611, USA.; The rate of development of disease varies considerably among human immunodeficiency virus type 1 (HIV-1)-infected children. The reasons for these observed differences are not clearly understood but most probably depend on the dynamic interplay between the HIV-1 quasispecies virus population and the immune constraints
Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells.: J Virol. 1997 Jan;71(1):715-9. Unique Identifier : AIDSLINE MED/97138377; Staskus KA; Zhong W; Gebhard K; Herndier B; Wang H; Renne R; Beneke J; Pudney J; Anderson DJ; Ganem D; Haase AT; Department of Microbiology, University of Minnesota, Minneapolis; 55455, USA.; The recent discovery of DNA sequences of a new human herpesvirus in Kaposi s sarcoma (KS) has fueled speculation that this virus might cause KS. The mere presence, however, of a virus in a complex multicellular tumor like KS could just as well be construed as evidence of a passenger agent. We sought stronger evidence
Toward highly efficient cell-type-specific gene transfer with retroviral vectors displaying single-chain antibodies.: J Virol. 1997 Jan;71(1):720-5. Unique Identifier : AIDSLINE MED/97138378; Chu TH; Dornburg R; Department of Molecular Genetics and Microbiology, Robert Wood Johnson; Medical School, University of Medicine and Dentistry of New Jersey,; Piscataway 08854, USA.; Recently, we constructed retroviral vector particles derived from spleen necrosis virus (SNV) that display a single-chain antibody scA) on the viral surface. By transient transfection protocols, we showed that such particles are competent for infection and cell type specific. Efficient infection was dependent on the p
Primer tRNA3Lys on the viral genome exists in unextended and two-base extended forms within mature human immunodeficiency virus type 1.: J Virol. 1997 Jan;71(1):726-8. Unique Identifier : AIDSLINE MED/97138379; Huang Y; Wang J; Shalom A; Li Z; Khorchid A; Wainberg MA; Kleiman L; Lady Davis Institute for Medical Research, Jewish General Hospital,; Quebec, Canada.; In human immunodeficiency virus type 1, tRNALys3 is placed upon the primer binding site, where it serves as the primer for reverse transcription. We show herein that genomic placement occurs independently of precursor protein processing and that the placed tRNALys3 exists in two major forms: unextended or in a form ex
The cellular stress response enhances human T-cell lymphotropic virus type 1 basal gene expression through the core promoter region of the long terminal repeat.: J Virol. 1997 Jan;71(1):741-5. Unique Identifier : AIDSLINE MED/97138383; Andrews JM; Newbound GC; Oglesbee M; Brady JN; Lairmore MD; Center for Retrovirus Research and Department of Veterinary; Biosciences, The Ohio State University, Columbus 43210, USA.; Viral protein expression is postulated to play a critical role in the pathogenesis of human T-cell lymphotropic virus type 1 HTLV-1)-associated diseases. Therefore, knowledge of the cellular events which initiate or enhance viral gene expression is important in understanding the mechanism of HTLV-1-induced disease. In
Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS.: J Virol. 1997 Jan;71(1):746-9. Unique Identifier : AIDSLINE MED/97138384; Yoshikai Y; Kidokoro H; Kimura K; Aoki Y; Makino M; Hiromatsu K; Research Institute for Disease Mechanism and Control, Nagoya; University School of Medicine, Japan.; yyoshika@tsuru.med.nagoya-u.ac.jp; Subcutaneous injection of FK506 (10 mg/kg of body weight) completely blocked the clonal expansion of staphylococcal enterotoxin A (SEA)-reactive T cells in healthy (control) mice after SEA injection but did not disturb it in mice with murine AIDS (MAIDS) caused by infection with LP-BM5 murine leukemia virus. MAIDS mic
The human T-cell lymphotropic virus type 1 Tof protein contains a bipartite nuclear localization signal that is able to functionally replace the amino-terminal domain of Rex.: J Virol. 1997 Jan;71(1):75-83. Unique Identifier : AIDSLINE MED/97138299; D'Agostino DM; Ciminale V; Zotti L; Rosato A; Chieco-Bianchi L; Department of Oncology and Surgical Sciences, University of Padua,; Italy. dmdago@ipdunidx.unipd.it; The X region of human T-cell lymphotropic virus type 1 (HTLV-1) encodes two nucleolar/nuclear proteins, the posttranscriptional regulator of mRNA expression Rex and a protein of unknown function named Tof. To gain insight into the possible biological role of Tof, we investigated the mechanism governing its intracellul
Antibody prevents the establishment of persistent arenavirus infection in synergy with endogenous T cells.: J Virol. 1997 Jan;71(1):755-8. Unique Identifier : AIDSLINE MED/97138386; Baldridge JR; McGraw TS; Paoletti A; Buchmeier MJ; Department of Neuropharmacology, Scripps Research Institute, La Jolla,; California 92037, USA.; A cardinal feature of the biology of lymphocytic choriomeningitis virus (LCMV) is its ability to establish persistent infections in mice. Persistence is usually established by infection of the mouse during the in utero or neonatal period. Susceptibility can be extended to the adult by treatment with immunosuppressive
Length polymorphism within the second variable region of the human immunodeficiency virus type 1 envelope glycoprotein affects accessibility of the receptor binding site.: J Virol. 1997 Jan;71(1):759-65. Unique Identifier : AIDSLINE MED/97138387; Fox DG; Balfe P; Palmer CP; May JC; Arnold C; McKeating JA; University of Reading, School of Animal and Microbial Sciences,; Whiteknights, United Kingdom.; Sequential mutations were introduced into the V2 region of human immunodeficiency virus (HIV) type 1 HXB2, affecting the length, charge, and number of potential glycosylation sites. The insertions had no effect on cytopathicity or on the ability of virus to replicate in peripheral blood mononuclear cells and establish
A sorting motif localizes the foamy virus glycoprotein to the endoplasmic reticulum.: J Virol. 1997 Jan;71(1):778-84. Unique Identifier : AIDSLINE MED/97138390; Goepfert PA; Shaw KL; Ritter GD Jr; Mulligan MJ; Department of Medicine, University of Alabama at Birmingham,; 35294-2170, USA.; We recently identified an endoplasmic reticulum (ER) retrieval signal-the dilysine motif-in the glycoproteins of all five foamy viruses (FVs) for which sequences were available (P. A. Goepfert, G. Wang, and M. J. Mulligan, Cell 82:543-544, 1995). In the present study, expression of recombinant human FV (HFV) glycoprot
Equivalent inhibition of half-site and full-site retroviral strand transfer reactions by structurally diverse compounds.: J Virol. 1997 Jan;71(1):807-11. Unique Identifier : AIDSLINE MED/97138395; Hazuda D; Felock P; Hastings J; Pramanik B; Wolfe A; Goodarzi G; Vora A; Brackmann K; Grandgenett D; Department of Antiviral Research, Merck Research Laboratories, West; Point, Pennsylvania 19486, USA.; In vitro assay systems which use recombinant retroviral integrase IN) and short DNA oligonucleotides fail to recapitulate the full-site integration reaction as it is known to occur in vivo. The relevance of using such circumscribed in vitro assays to define inhibitors of retroviral integration has not been formerly de
Mapping the multimerization domains of the Gag protein of yeast retrotransposon Ty1.: J Virol. 1997 Jan;71(1):812-7. Unique Identifier : AIDSLINE MED/97138396; Brachmann CB; Boeke JD; Department of Molecular Biology and Genetics, Johns Hopkins University; School of Medicine, Baltimore, Maryland 21205, USA.; The two-hybrid system was used to define regions of the Ty1 Gag protein responsible for multimerization. Gag truncations lacking the first 146 or the last 97 amino acids (Gag is 440 amino acids in length) interact. A severely C-terminally truncated molecule lacking the last 207 amino acids) was the smallest truncation
Human herpesvirus 8 encodes a homolog of interleukin-6.: J Virol. 1997 Jan;71(1):839-42. Unique Identifier : AIDSLINE MED/97138401; Neipel F; Albrecht JC; Ensser A; Huang YQ; Li JJ; Friedman-Kien AE; Fleckenstein B; Institut fur Klinische und Molekulare Virologie, Universitat; Erlangen-Nurnberg, Erlangen, Germany. neipel@viro.med.uni-erlangen.de; Kaposi s sarcoma is a multifocal lesion that is reported to be greatly influenced by cytokines such as interleukin-6 (IL-6) and oncostatin M. DNA sequences of a novel human gammaherpesvirus, termed human herpesvirus 8 (HHV-8) or Kaposi sarcoma-associated herpesvirus, have been identified in all epidemiological forms o
Subcellular localization of avian sarcoma virus and human immunodeficiency virus type 1 integrases.: J Virol. 1997 Jan;71(1):843-7. Unique Identifier : AIDSLINE MED/97138402; Kukolj G; Jones KS; Skalka AM; Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia,; Pennsylvania 19111, USA.; The composition and subcellular trafficking of subviral preintegration complexes are reported to vary among the different retroviruses. The process by which the avian sarcoma virus (ASV) preintegration complex gains access to target chromatin remains unknown. Here we report that ASV integrase (IN) expressed as a fusio
Identification of an RNA sequence within an intracisternal-A particle element able to replace Rev-mediated posttranscriptional regulation of human immunodeficiency virus type 1.: J Virol. 1997 Jan;71(1):95-101. Unique Identifier : AIDSLINE MED/97138301; Tabernero C; Zolotukhin AS; Bear J; Schneider R; Karsenty G; Felber BK; Human Retrovirus Pathogenesis Group, National Cancer; Institute-Frederick Cancer Research and Development Center, Frederick,; Maryland 21702-1201, USA.; Human immunodeficiency virus type 1 (HIV-1) replication depends on the posttranscriptional regulation by the viral Rev protein and can be replaced with the posttranscriptional RNA control element (CTE) of the type D simian retroviruses. We have identified a sequence which shares only nucleotide sequences of the intern
Hospital variation in intrapartum use of zidovudine [letter]: JAMA. 1997 Jan 22-29;277(4):299. Unique Identifier : AIDSLINE MED/97155986; Gwinn M; Mei JV; Spruill CL; Dobbs TL; Hannon WH; LaLota M
[Cord blood stem cell transplantation for a patient with acute myelogenous leukemia (M1)]: Rinsho Ketsueki. 1996 Dec;37(12):1371-6. Unique Identifier : AIDSLINE MED/97150534; Hattori K; Yabe H; Yabe M; Morimoto T; Iwasaki K; Nakamura Y; Inoguchi S; Tsuji K; Kato S; Department of Pediatrics, Tokai University School of Medicine.; A five-year-old boy with acute myelogenous leukemia in relapse was treated by HLA-matched cord blood stem cell transplantation. The patient was preconditioned with 16 mg/kg of busulfan, 15 mg/kg of thiotepa and 90 mg/kg of cyclophosphamide and 2.45 x 10(7)/kg of cord blood mononuclear cells were infused to the patient
Dental service use among adults with human immunodeficiency virus infection.: Med Care. 1997 Jan;35(1):77-85. Unique Identifier : AIDSLINE MED/97152273; Fleishman JA; Schneider DA; Garcia I; Hardwick K; Center for Cost and Financing, Agency for Health Care Policy and; Research, Rockville, MD 20852, USA.
Is death inevitable with multiresistant TB plus HIV infection? [see comments] [published erratum appears in Lancet 1997 Mar 15;349(9054):810]: Lancet. 1997 Jan 11;349(9045):71-2. Unique Identifier : AIDSLINE MED/97149604; Drobniewski F; PHLS Mycobacterium Reference Unit, King's College School of Medicine,; Londor, UK.
Expansion of T cells negative for CD28 expression in HIV infection. Relation to activation markers and cell adhesion molecules, and correlation with prognostic markers.: Med Microbiol Immunol (Berl). 1996 May;185(1):19-25. Unique Identifier : AIDSLINE MED/96396846; Kammerer R; Iten A; Frei PC; Burgisser P; Institute for Medical Microbiology, Medizinische Universitat zu; Lubeck, Germany.; CD28 is a transmembrane glycoprotein that provides T cells with an essential co-stimulatory signal during antigen presentation. Using flow cytometry, we document here an expansion of CD28- T cells in HIV infection. Whereas the percentage of CD4+CD28+ T cells among total lymphocytes was decreased, a small increase of t
Evaluation of brain and nerve pathology in rats chronically dosed with ddI or isoniazid.: Neurotoxicol Teratol. 1996 Sep-Oct;18(5):555-63. Unique Identifier : AIDSLINE MED/97042822; Schmued LC; Albertson CM; Andrews A; Sandberg JA; Nickols J; Slikker W Jr; Division of Neurotoxicology, National Center for Toxicological; Research, Jefferson, AR 72079, USA.; The antiviral adenosine analog, 2 ,3 -dideoxyinosine (ddI), and the antitubercular nicotinic acid analogue, isoniazid, have recently received widespread clinical application in the treatment of acquired immunodeficiency syndrome (AIDS). Clinical studies indicate that the primary dose limiting side effect of both drugs
1997 revised guidelines for performing CD4+ T-cell determinations in persons infected with human immunodeficiency virus (HIV). Centers for Disease Control and Prevention.: MMWR Morb Mortal Wkly Rep. 1997 Jan 10;46(RR-2):1-29. Unique Identifier : AIDSLINE MED/97157595; These revised guidelines were developed by CDC for laboratories performing lymphocyte immunophenotyping assays in human immunodeficiency virus-infected persons. This report updates previous recommendations (MMWR 43[No. RR-3]) and reflects current technology in a field that is rapidly changing. The recommendations addr
Evaluation of safety devices for preventing percutaneous injuries among health-care workers during phlebotomy procedures--Minneapolis-St. Paul, New York City, and San Francisco, 1993-1995.: MMWR Morb Mortal Wkly Rep. 1997 Jan 17;46(2):21-5. Unique Identifier : AIDSLINE MED/97157590; Health-care workers (HCWs) are at risk for infections with bloodborne pathogens resulting from occupational exposures to blood through percutaneous injuries (PIs). Phlebotomy, one of the most commonly performed medical procedures, has been associated with 13% - 62% of injuries reported to hospital occupational health
A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus.: Mol Cell Biol. 1996 Dec;16(12):7144-50. Unique Identifier : AIDSLINE MED/97098693; Stutz F; Izaurralde E; Mattaj IW; Rosbash M; Department of Biology, Howard Hughes Medical Institute, Brandeis; University, Waltham, Massachusetts 02254, USA.; The human immunodeficiency virus type 1 Rev protein contains a nuclear export signal (NES) that is required for Rev-mediated RNA export in mammals as well as in the yeast Saccharomyces cerevisiae. The Rev NES has been shown to specifically interact with a human (hRIP/RAB1) and a yeast (yRip1p) protein in the two-hybri
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 4-1997. A 37-year-old man with AIDS and wheezing refractory to bronchodilator medication [clinical conference]: N Engl J Med. 1997 Jan 30;336(5):357-64. Unique Identifier : AIDSLINE MED/97156230
Physician-assisted suicide and patients with human immunodeficiency virus disease [see comments]: N Engl J Med. 1997 Feb 6;336(6):417-21. Unique Identifier : AIDSLINE MED/97156027; Slome LR; Mitchell TF; Charlebois E; Benevedes JM; Abrams DI; San Francisco, CA 94110, USA.; BACKGROUND: Data are limited on the attitudes and practices of physicians regarding assisting the suicide of patients with human immunodeficiency virus (HIV) disease. METHODS: Between November 1994 and January 1995, we used an anonymous, self-administered questionnaire to survey all 228 physicians in the Community Con
Cryptococcus neoformans var. gattii among patients with cryptococcal meningitis in Mexico. First observations.: Mycopathologia. 1996;134(2):61-4. Unique Identifier : AIDSLINE MED/97136247; Lopez-Martinez R; Soto-Hernandez JL; Ostrosky-Zeichner L; Castanon-Olivares LR; Angeles-Morales V; Sotelo J; Departamento de Microbiologia y Parasitologia, Facultad de Medicina,; Universidad Nacional Autonoma de Mexico, Mexico, D.F.; A retrospective study of 20 patients with cryptococcal meningitis and their isolated strains was performed. Cryptococcus neoformans var. neoformans was recovered from 14 (70%) cases, and var. gattii was recovered from six (30%) patients. Twelve patients had AIDS (all carrying var. neoformans), two had other diseases (
Pirated genes in Kaposi's sarcoma [news; comment]: Nature. 1997 Jan 23;385(6614):296-7, 299. Unique Identifier : AIDSLINE MED/97156006; Murphy PM
Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation [see comments]: Nature. 1997 Jan 23;385(6614):347-50. Unique Identifier : AIDSLINE MED/97156016; Arvanitakis L; Geras-Raaka E; Varma A; Gershengorn MC; Cesarman E; Department of Pathology, Cornell University Medical College, New York; 10021, USA.; Kaposi s sarcoma-associated herpesvirus (KSHV, also known as human herpesvirus 8, or HHV 8) is a virus that is consistently present in Kaposi s sarcoma and in primary-effusion body-cavity-based) lymphomas, malignancies that occur frequently, but not exclusively, in AIDS patients. KSHV is a gamma herpesvirus with homol
Painful vasculitic neuropathy in HIV-1 infection: relief of pain with prednisone therapy.: Neurology. 1996 Dec;47(6):1446-51. Unique Identifier : AIDSLINE MED/97120054; Bradley WG; Verma A; Department of Neurology, University of Miami School of Medicine, FL; 33136, USA.; Painful distal sensory polyneuropathy (DSP) is the most common peripheral neuropathy in patients with human immunodeficiency virus-1 (HIV-1) infection. There is no specific therapy for DSP, and nonspecific treatment with pain blockers and narcotic agents generally fai
Pattern electroretinograms and visual evoked potentials in HIV infection: evidence of asymptomatic retinal and postretinal impairment in the absence of infectious retinopathy.: Neurology. 1996 Dec;47(6):1452-6. Unique Identifier : AIDSLINE MED/97120055; Iragui VJ; Kalmijn J; Plummer DJ; Sample PA; Trick GL; Freeman WR; Department of Neurosciences, University of California San Diego School; of Medicine, USA.; Retinal microangiopathy associated with HIV infection is usually asymptomatic and escapes detection unless funduscopic examination is performed when evanescent cotton-wool spots are present. The aim of this study was to assess retinal and optic nerve/retrochiasmal function in HIV infection by means of electrophysiolog
T-cell subpopulations in the cerebrospinal fluid and peripheral blood of patients with multiple sclerosis: a follow-up study.: Neurology. 1996 Dec;47(6):1542-5. Unique Identifier : AIDSLINE MED/97120071; Oksaranta O; Tarvonen S; Ilonen J; Poikonen K; Reunanen M; Panelius M; Salonen R; Turku Immunology Centre, Finland.; We analyzed the relative and absolute numbers of CD4+ cells positive and negative for CD45RA marker as well as the numbers of CD8+ cells positive and negative for CD11b in the cerebrospinal fluid (CSF) and peripheral blood (PB) of 17 patients with multiple sclerosis (MS) during and 60 days after an exacerbation. We al
Levodopa therapy improves motor function in HIV-infected children with extrapyramidal syndromes.: Neurology. 1996 Dec;47(6):1583-5. Unique Identifier : AIDSLINE MED/97120081; Mintz M; Tardieu M; Hoyt L; McSherry G; Mendelson J; Oleske J; Division of Pediatric Neurology, UMDNJ-Robert Wood Johnson Medical; School at Camden 08103, USA.; Five children with human immunodeficiency virus type-1 (HIV-1) infection, aged 4 to 13 years, manifested extrapyramidal dysfunction characterized by rigidity/stiffness, ambulation difficulties/shuffling gait, dysarthria/drooling/swallowing dysfunction, hypomimetic/inexpressive facies, and bradykinesia. Levodopa therap
HIV legal update--Part 3.: Nurs Manage. 1996 Dec;27(12):11, 14. Unique Identifier : AIDSLINE MED/97158431; Fiesta J; The human immunodeficiency virus (HIV) legal update continues to review claims involving health care providers. Areas discussed include informed consent litigation, confidentiality issues and rights of employees.
Phenotypic profiles of lymphocyte populations isolated from rat major salivary glands.: Oral Microbiol Immunol. 1996 Aug;11(4):248-53. Unique Identifier : AIDSLINE MED/97156487; Montgomery PC; Skandera CA; O'Sullivan NL; Department of Immunology and Microbiology, Wayne State University; School of Medicine, Detroit, Michigan 48201, USA.; Marker expression was studied in rat lymphocyte populations isolated from parotid, submandibular and sublingual salivary glands. Comparative data were also obtained for lacrimal gland and spleen populations. Increased percentages of Thy-1+ cells were found in salivary gland populations when compared to spleen with the
Putting prevention into nursing practice.: N J Nurse. 1996 Nov;26(9):5, 7. Unique Identifier : AIDSLINE MED/97158412; Redeker NS
Psychosocial aspects of antiretroviral medication use among HIV patients.: Patient Educ Couns. 1996 Nov;29(2):207-19. Unique Identifier : AIDSLINE MED/97158879; Aversa SL; Kimberlin C; Institute of Government and Public Affairs, University of Illinois,; Urbana-Champaign 61801, USA.; This study examines variables related to alteration of antiretroviral medication regimens by HIV infected persons, independent of medical advice. Perceived severity, susceptibility, benefits/barriers, cues to action, and locus of control were included in the analyses. Of 99 subjects, 37 reported discontinuing antiretr
Isolates of Encephalitozoon cuniculi from farmed blue foxes Alopex lagopus) from Norway differ from isolates from Swiss domestic rabbits (Oryctolagus cuniculus).: Parasitol Res. 1996;82(8):727-30. Unique Identifier : AIDSLINE MED/97052879; Mathis A; Akerstedt J; Tharaldsen J; Odegaard O; Deplazes P; Institute of Parasitology, CH-8057 Zurich, Switzerland.; Encephalitozoon cuniculi has a wide host range among mammals, but whether it represents a homogeneous species is a subject of controversy. We have isolated, cultivated (in human MRC-5 cells) and, for the first time, characterized by immunological and molecular biological methods four isolates of E. cuniculi from Norwe
Normal-mode analysis suggests important flexibility between the two N-terminal domains of CD4 and supports the hypothesis of a conformational change in CD4 upon HIV binding.: Protein Eng. 1996 Aug;9(8):671-7. Unique Identifier : AIDSLINE MED/97029634; Sanejouand YH; Laboratoire de Physique Quantique, UMR, CNRS, IRSAMC, Universite; Paul-Sabatier, Toulouse, France.; Human CD4 is the receptor for human immunodeficiency virus (HIV). It is well established that the first domain of CD4 binds with high affinity to gp120, an envelope protein of HIV, but it has also been demonstrated that amino acids located in its second domain, within or close to residues 120-127 or 163-166 (lying 15
Molecular mechanics calculations on HIV-1 protease with peptide substrates correlate with experimental data.: Protein Eng. 1996 Aug;9(8):679-90. Unique Identifier : AIDSLINE MED/97029635; Weber IT; Harrison RW; Department of Pharmacology, Jefferson Cancer Center, Thomas Jefferson; University, Philadelphia, PA 19107, USA.; Molecular models of HIV-1 protease and 21 peptide substrates with single amino acid substitutions at positions from P4 to P3 were built and compared with kinetic measurements. The crystal structure of HIV-1 protease with a peptidic inhibitor was modified to model the peptide substrate Pro-Ala-Val-Ser-Leu-Ala-Met-Thr
A versatile and rapid assay of radiosensitivity of peripheral blood leukocytes based on DNA and surface-marker assessment of cytotoxicity.: Radiat Res. 1997 Jan;147(1):55-60. Unique Identifier : AIDSLINE MED/97143359; Crompton NE; Ozsahin M; Institute for Medical Radiobiology, University of Zurich, Switzerland.; We describe a rapid assay to predict intrinsic radiosensitivity of normal tissues based on the radiation-induced cytotoxic response of a number of types of white blood cells. Twenty-four hours after irradiation, leukocytes were prepared for analysis by flow cytometry. Radiation-induced cytotoxicity was characterized b
The acquired immunodeficiency syndrome and endemic diseases in Brazil [editorial]: Rev Soc Bras Med Trop. 1996 Nov-Dec;29(6):531-5. Unique Identifier : AIDSLINE MED/97122768; Ferreira MS
[Oocysts of Cryptosporidium sp in feces: comparison of the modified Kinyoun and Heine methods]: Rev Soc Bras Med Trop. 1996 Nov-Dec;29(6):575-8. Unique Identifier : AIDSLINE MED/97122775; Amato Neto V; Braz LM; Di Pietro AO; Modolo JR; Laboratorio de Investigacao Medica-Parasitologia, Universidade de Sao; Paulo.; The diagnosis of intestinal infection by Cryptosporidium sp is crucial today; with the progression of the AIDS epidemic, many cases of cryptosporidiosis have appeared in this setting and in other immunodeficiency diseases. We compared the advantages and disadvantages of Heine s method and modified Kinyoun s method in
[Psoriasis in HIV positive patients]: Rev Soc Bras Med Trop. 1996 Nov-Dec;29(6):599-602. Unique Identifier : AIDSLINE MED/97122779; Silva-Vergara ML; Pineli MR; Galati MC; Correia D; Departamento de Clinica Medica, Faculdade de Medicina do Triangulo; Mineiro, MG.; Two patients with the acquired immunodeficiency syndrome (AIDS) developed psoriasis, one of them presenting the more severe form and the other one the milder form of the disease, were treated with zidovudine per oral via, 200mg 3 times a day. In the first case the therapeutical response was complete. No lesion was ver
[Occurrence of false positives in tests with synthetic peptides for the analysis of antibodies against the human immunodeficiency virus type 2 (HIV-2) in Brazilian patients infected with the human immunodeficiency virus type 1 (HIV-1)]: Rev Soc Bras Med Trop. 1996 Nov-Dec;29(6):615-7. Unique Identifier : AIDSLINE MED/97122783; Machado AA; Hirsch I; Figueiredo JF; Martinez R; de Freitas-Silva G; Chermann JC; Covas DT; Departamento de clinica medica da faculdade de medicina de Ribeirao; Preto da Universidade de Sao Paulo.
[Campylobacter jejuni infections in a prison population coinfected with the human immunodeficiency virus]: Rev Clin Esp. 1996 Jan;196(1):16-20. Unique Identifier : AIDSLINE MED/97106089; Fernandez-Martin JI; Dronda F; Chaves F; Alonso-Sanz M; Catalan S; Gonzalez-Lopez A; Unidad de Enfermedades Infecciosas-Microbiologia Clinica, Hospital; General Penitenciario, Madrid.; BACKGROUND: Campylobacter jejuni is a common etiological agent of diarrhea in the general population. In recent years it has also been involved as etiological agent of intestinal and extraintestinal infections in patients infected with the human immunodeficiency virus (HIV). The clinical and microbiological features i
[Drug-resistant tuberculosis at a general hospital]: Rev Clin Esp. 1996 Jan;196(1):21-3. Unique Identifier : AIDSLINE MED/97106090; Miralles Martin P; Moreno Guillen S; Parras Vazquez F; Cosin Ochaita J; Cercenado Mansilla E; Ortega Calderon A; Bouza Santiago E; Unidad de Enfermedades Infecciosas-VIH, Hospital General Universitario; Gregorio Maranon, Madrid.; OBJECTIVES: To determine the prevalence of M. tuberculosis isolates resistant to drugs in a general hospital and to assess its association with HIV infection. MATERIALS AND METHODS: Susceptibility analysis of all isolates of M. tuberculosis in a 4-year period (1990-1993). The proportion method was used to study the su
[Wasting syndrome in patients with HIV infection]: Rev Clin Esp. 1996 Jan;196(1):32-8. Unique Identifier : AIDSLINE MED/97106093; Alvarez Hernandez J; Servicio de Endocrinologia, Hospital Universitario Principe de; Asturias, Madrid.
[Extrapulmonary tuberculosis in patients without human immunodeficiency virus infection. Review of relevant clinical aspects]: Rev Clin Esp. 1996 Jan;196(1):39-48. Unique Identifier : AIDSLINE MED/97106094; Ramos Rincon JM; Fernandez Guerrero ML; Division de Enfermedades Infecciosas, Fundacion Jimenez Diaz,; Universidad Autonoma, Madrid.
[Fever of unknown origin in patients infected with the human immunodeficiency virus]: Rev Clin Esp. 1996 Jan;196(1):4-8. Unique Identifier : AIDSLINE MED/97106087; Carbonell Biot C; Ena Munoz J; Pasquau Liano F; Badia Ferrando P; Ortiz de Salazar Martin A; Vilar Zanon A; Servicio de Medicina Interna, Hospital Marina Baixa, Villajoyosa,; Alicante.; BACKGROUND: To describe the clinical features and the final diagnosis of patients infected with human immunodeficiency virus who presented fever of unknown origin. METHODS: Retrospective study, from November 1989 to January 1994, of all patients infected with HIV who had fever of unknown origin and who were admitted t
[Hyperkeratotic lesions in a patient with AIDS]: Rev Clin Esp. 1996 Jan;196(1):55-6. Unique Identifier : AIDSLINE MED/97106098; Fernandez-Martin JI; Gonzalez-Lopez A; Alonso-Sanz M; Lecona M; Dronda F; Unidad de Enfermedades Infecciosas-Microbiologia, Hospital General; Penitenciario, Madrid.
[Fever, cough, and radiologic lung condensation in an HIV+ patient]: Rev Clin Esp. 1996 Jan;196(1):57. Unique Identifier : AIDSLINE MED/97106099; Gomez Martinez MV; Gallardo FG; Soriano V; Castro-Beiras JM; Servicio de Medicina Nuclear, Instituto de Salud Carlos III, Madrid.
[HTLV-I infection in Spanish drug addicts (letter)]: Rev Clin Esp. 1996 Jan;196(1):59-60. Unique Identifier : AIDSLINE MED/97106102; Aguilera O; Gutierrez M; Mas A; Gonzalez-Castelao G; Soriano V
[Overdose of zidovudine (letter)]: Rev Clin Esp. 1996 Jan;196(1):60-1. Unique Identifier : AIDSLINE MED/97106103; Chocarro Martinez A; Gonzalez Lopez A; Chimeno Vinas M; Villafane C
[Primary pulmonary hypertension in a female patient with HIV infection (letter)]: Rev Clin Esp. 1996 Jan;196(1):61-2. Unique Identifier : AIDSLINE MED/97106104; Arranz Caso A; Herrera Serrano L; Cuadrado Gomez LM; Gonzalez Estecha A
[Histopathology of bone marrow biopsy in patients with human immunodeficiency virus infection]: Rev Clin Esp. 1996 Jan;196(1):9-15. Unique Identifier : AIDSLINE MED/97106088; Paradela A; Rivas C; Fernandez-Guerrero M; Roman A; Departamento de Anatomia Patologica, Universidad Autonoma, Madrid.; PURPOSE: To describe morphology of bone marrow (BM) biopsy in HIV infected patients. To correlate histopathologic findings and clinico-haematological data. To consider the advantages of this method (BM biopsy) in the diagnosis of secondary infectious or tumoural accompanying processes. MATERIAL AND METHODS: One hundre
Clinical versus fundus photographic evaluation of the status of cytomegalovirus retinitis in AIDS patients.: Retina. 1996;16(5):363-72. Unique Identifier : AIDSLINE MED/97069981; Flores-Aguilar M; Munguia D; Besen G; Gangan P; Arevalo JF; Freeman WR; Department of Ophthalmology, University of California, San Diego,; Shiley Eye Center, LaJolla 92093-0946, USA.; PURPOSE: To evaluate the accuracy of clinical examinations and serial fundus photographic readings in determining the response of cytomegalovirus retinitis to antiviral therapy in patients with acquired immune deficiency syndrome. METHODS: Fifty two consecutive patients with cytome
Fluorescein angiography in the progressive outer retinal necrosis syndrome.: Retina. 1996;16(5):393-8. Unique Identifier : AIDSLINE MED/97069985; Walton RC; Byrnes GA; Chan CC; Nussenblatt RB; Laboratory of Immunology, National Eye Institute, National Institutes; of Health, Bethesda, Maryland, USA.; PURPOSE: Progressive outer retinal necrosis syndrome is a devastating retinopathy seen primarily in patients with acquired immune deficiency syndrome. To provide additional details of the pathogenesis of this disease, the authors describe the evolution of clinical and fluorescein angiographic changes during the course
[Are there factors which maintain a subjective symptom-free psychological state? A study exemplified with HIV-infected subjects]: Schweiz Med Wochenschr. 1996 Dec 28;126(51-52):2209-16. Unique Identifier : AIDSLINE MED/97152824; Eich-Hochli D; Niklowitz M; Opravil M; Abteilung Infektionskrankheiten und Spitalhygiene, Department Innere; Medizin, Universitatsspital Zurich.; AIMS: In the absence of curative treatment, the diagnosis of HIV infection imposes a heavy burden. Infected persons are therefore confronted with psychological, social and physical problems and cope with them via different strategies and social resources. We investigated the question of what factors help to maintain a
[Sex differences in disease course: analysis of the Swiss HIV cohort study]: Schweiz Med Wochenschr. 1996 Dec 28;126(51-52):2234-6. Unique Identifier : AIDSLINE MED/97152827; Schmid M; Twisselmann W; Jacquat BJ; Ledergerber B; Battegay M; Egger M; Koordinationsstelle Gesundheit von Frauen, Zurich, Institut fur; Sozial- und Praventivmedizin, Universitat Zurich.; The Swiss HIV Cohort Study (SHCS) is a prospective multicentre study of HIV-infected adults. Participants have been followed up at six-monthly intervals since 1988. The purpose of the present study was to examine sex differences in developing AIDS-defining events and in survival among participants of the SHCS (1042 wo
Mycobacterial disease--old problems, new solutions.: Soc Appl Bacteriol Symp Ser. 1996;25:viiS-viiiS. Unique Identifier : AIDSLINE MED/97127276; Collins CH; Grange JM; Imperial College of Science, Technology and Medicine National Heart; and Lung Institute, London, UK.
The resurgence of tuberculosis.: Soc Appl Bacteriol Symp Ser. 1996;25:23S-26S. Unique Identifier : AIDSLINE MED/97127279; Parry C; Davies PD; Welcome Trust Clinical Research Unit, Ho Chi Minh City, Vietnam.
The bovine tuberculosis cycle--an African perspective.: Soc Appl Bacteriol Symp Ser. 1996;25:27S-32S. Unique Identifier : AIDSLINE MED/97127280; Daborn CJ; Grange JM; Kazwala RR; Centre for Tropical Veterinary Medicine, Edinburgh University, Easter; Bush, Roslin, Midlothian, UK.
Mycobacterium avium complex in AIDS: who, when, where, why and how?: Soc Appl Bacteriol Symp Ser. 1996;25:40S-46S. Unique Identifier : AIDSLINE MED/97127282; Pozniak AL; Uttley AH; Kent RJ; Department of Genitouninary Medicine, King's College Hospital London,; UK.
The application of molecular techniques to the diagnosis and epidemiology of mycobacterial diseases.: Soc Appl Bacteriol Symp Ser. 1996;25:53S-71S. Unique Identifier : AIDSLINE MED/97127284; Butcher PD; Hutchinson NA; Doran TJ; Dale JW; Department of Medical Microbiology, St George's Hospital Medical; School, London, UK.
Idiopathic midesophageal stricture: a new cause of dysphagia in a patient with AIDS.: South Med J. 1997 Jan;90(1):80-2. Unique Identifier : AIDSLINE MED/97157548; Shapiro BD; Ehrenpreis ED; Tomaka FL; Bonner GF; Secrest KM; Cheney LM; Department of Gastroenterology, Cleveland Clinic Florida, USA.; A number of disorders may result in the complaint of dysphagia in HIV-infected patients. These include fungal, viral, bacterial, parasitic, medication-induced, and idiopathic lesions in the esophagus. In the current case, a 32-year-old man with advanced HIV infection had recurrent bouts of esophageal stricture. No ulc
Possible HLA association with susceptibility to HTLV-1 tropical spastic paraparesis in Israel in Iranian Jews as compared to HTLV 1-associated myelopathy in Japan.: Tissue Antigens. 1996 Aug;48(2):136-8. Unique Identifier : AIDSLINE MED/97037656; Shohat B; Achiron A; Narinski R; Kochba I; Sidi Y; Sonada S; Osame M; Klein T; Cellular Immunology Unit, Beilinson Medical Center, Petah Tiqva,; Israel.
Evaluating the program effects of a radio drama about AIDS in Zambia [see comments]: Stud Fam Plann. 1996 Jul-Aug;27(4):188-203. Unique Identifier : AIDSLINE MED/97029722; Yoder PS; Hornik R; Chirwa BC; Annenberg School for Communications, University of Pennsylvania,; Philadelphia 19104-6220, USA.; This study describes an approach to the analysis of data that is designed to isolate program effects for evaluations and applies that approach to a program in Zambia designed to disseminate AIDS information. Evidence is considered that a radio drama broadcast for nine months had an
An atypical T-cell lymphosarcoma in a calf with bovine immunodeficiency-like virus infection.: Vet Pathol. 1996 Jul;33(4):457-9. Unique Identifier : AIDSLINE MED/96414850; Rovid AH; Carpenter S; Miller LD; Flaming KP; Long MJ; Van der Maaten MJ; Frank DE; Roth JA; Department of Microbiology, Immunology, and Preventive Medicine, Iowa; State University, Ames 50011, USA.; An 11-month-old Holstein calf experimentally infected with bovine immunodeficiency-like virus (BIV) developed T-cell lymphosarcoma 5 months postinoculation, concurrent with progressive monocytosis. Tumors were found in the thymus, multiple lymph nodes, and brain. Tumor cells were CD2+, CD4-, CD8-T cells. Infectious BI
Manifestations of the local gastric immune response in gnotobiotic piglets infected with Helicobacter pylori.: Vet Immunol Immunopathol. 1996 Jul;52(3):159-73. Unique Identifier : AIDSLINE MED/96405873; Krakowka S; Ringler SS; Eaton KA; Green WB; Leunk R; Department of Veterinary Biosciences, College of Veterinary Medicine,; Ohio State University, Columbus 43210, USA.; Helicobacter pylori, a human gastric bacterial pathogen, was inoculated into gnotobiotic piglets and manifestations of the resultant gastric inflammation was analyzed by in situ immunochemistry and flow cytometric analysis of isolated lamina propria leukocytes (LPL) and peripheral blood leukocytes (PBL) recovered from
Epidemiology and control of coccidioidomycosis in California.: West J Med. 1996 Oct;165(4):221-2. Unique Identifier : AIDSLINE MED/97141075; Rutherford GW; Barrett MF
Hepatitis A vaccine responses in HIV-positive persons with haemophilia.: Vaccine. 1996 Aug;14(11):1039-41. Unique Identifier : AIDSLINE MED/97033352; Tilzey AJ; Palmer SJ; Harrington C; O'Doherty MJ; Guy's and St Thomas' Hospital Trust, St Thomas' Hospital, London, UK.; The safety and immunogenicity of subcutaneously (s.c.) administered hepatitis A (HA) vaccine was evaluated in HIV positive and negative patients with haemophilia and healthy male controls. The vaccine was well tolerated. Seroconversion occurred among all controls after one dose of vaccine but was delayed among patient
Receptor interference mediated by the envelope glycoproteins of various HIV-1 and HIV-2 isolates.: Virus Res. 1996 Dec;45(2):135-45. Unique Identifier : AIDSLINE MED/97051522; Martin RA; Nayak DP; Department of Microbiology and Immunology, Jonsson Comprehensive; Cancer Center, University of California at Los Angeles, UCLA School of; Medicine 90024-1747, USA.; The envelope glycoprotein of human immunodeficiency virus type 1 HIV-1) plays a major role in the down-regulation of its receptor, CD4. This down-regulation, at least in part, is caused by the formation of gp160-CD4 intracellular complexes which fail to transport out of the endoplasmic reticulum (ER). In this report,
Hepatitis C virus core protein inhibits human immunodeficiency virus type 1 replication.: Virus Res. 1996 Dec;45(2):87-92. Unique Identifier : AIDSLINE MED/97051517; Srinivas RV; Ray RB; Meyer K; Ray R; Division of Infectious Diseases, St. Jude Children's Research; Hospital, Memphis, TN 38105, USA.; We previously demonstrated that hepatitis C virus (HCV) core protein is a strong repressor of human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) basal transcription. In this study, we have localized the HCV core protein-response domain to a region between nucleotides -65 and +3 within the HIV-LTR.
Lymphoproliferation assays in cattle naturally infected with bovine leukaemia virus (BLV) and bovine immunodeficiency-like virus (BIV).: Zentralbl Veterinarmed [B]. 1996 Aug;43(6):325-32. Unique Identifier : AIDSLINE MED/96387154; Hidalgo G; Bonilla JA; Centro de Investigacion en Biologia Celular y Molecular, Universidad; de Costa Rica, San Pedro, Costa Rica.; Experiments were designed to evaluate the effect of BLV on mitogen-stimulated peripheral blood mononuclear cells (PBMC) from naturally infected cattle. BIV was also taken into consideration due to a recent report showing that in Costa Rica , most of the BLV-infected animals are a
CD8 and CD4 T cell-mediated polymyositis complicating the HTLV-1 associated myelopathy. Quantitative evaluation of corticosteroid treatment.: Acta Neurol Scand. 1996 Aug;94(2):115-9. Unique Identifier : AIDSLINE MED/97046134; Waclawik AJ; Fadic R; Lotz BP; Beinlich BR; Lewandoski PJ; Sanjak M; Brooks BR; Neuromuscular Unit, University of Wisconsin Medical School, Madison; 53792, USA.; INTRODUCTION: Inflammatory myopathy is a treatable cause of worsening in the spectrum of neurological conditions that may develop during the course of HTLV-1 infection. MATERIAL AND METHODS: To investigate the cause of subacute worsening in the strength of a 46-y-old black male with HTLV-1 associated myelopathy we per
Nuclear and mitochondrial changes of co-cultivated spinal cord, spinal ganglia and muscle fibers following treatment with various doses of zidovudine.: Acta Neuropathol (Berl). 1996 Aug;92(2):138-49. Unique Identifier : AIDSLINE MED/96439328; Schroder JM; Kaldenbach T; Piroth W; Institut fur Neuropathologie, Klinikum der Rheinisch-Westfalischen; Technischen Hochschule, Aachen, Germany.; Long-term zidovudine (also termed azidothymidine, AZT ) treatment of AIDS patients may cause severe myopathy characterized by conspicuous mitochondrial and nuclear changes. The mitochondrial changes are attributed to an inhibitory effect of AZT on the
Degeneration of the cerebellar dentate nucleus and the inferior olivary nuclei in HIV-1-infected brains: a morphometric analysis.: Acta Neuropathol (Berl). 1996 Aug;92(2):150-5. Unique Identifier : AIDSLINE MED/96439329; Abe H; Mehraein P; Weis S; Institute of Neuropathology, Ludwig-Maximilian University, Munich,; Germany.; Motor dysfunction is frequently noted in human immunodeficiency virus type 1 (HIV-1)-infected patients. Until recently, neuropathological changes found in the basal ganglia were advanced as pathogenetic mechanisms. In the present study, further brain structures involved in motor control were analyzed morphometrically.
Varicella-zoster ventriculo-encephalitis and spinal cord infarction in a patient with AIDS.: Acta Neuropathol (Berl). 1996 Aug;92(2):202-5. Unique Identifier : AIDSLINE MED/96439336; Kenyon LC; Dulaney E; Montone KT; Goldberg HI; Liu GT; Lavi E; Department of Pathology and Laboratory Medicine, University of; Pennsylvania Medical Center, Philadelphia 19104-6079, USA.; Varicella-zoster virus (VZV) infection is usually benign and self-limited. However, particularly in the immunosuppressed host, serious central nervous system complications may occur, including encephalitis, myelitis, and cerebral vascular occlusion. We report the case of a 57-year-old male with AIDS, who rapidly devel
The main HTLV-I-harboring cells in the muscles of viral carriers with polymyositis are not macrophages but CD4+ lymphocytes.: Acta Neuropathol (Berl). 1996 Oct;92(4):358-61. Unique Identifier : AIDSLINE MED/97046145; Higuchi I; Hashimoto K; Matsuoka E; Rosales R; Nakagawa M; Arimura K; Izumo S; Osame M; Third Department of Internal Medicine, Faculty of Medicine, Kagoshima; University, Japan. ihiguchi@med6.kufm.kagoshima-u.ac.jp; We have analyzed muscle biopsy specimens from polymyositis patients who are also positive for human T cell lymphotropic virus type I (HTLV-I) using both immunohistochemistry for surface antigens of lymphocytes and macrophages and in situ polymerase chain reaction for HTLV-I proviral DNA on the same sections. We found
Coinfection of the central nervous system by cytomegalovirus and herpes simplex virus type 1 or 2 in AIDS patients: autopsy study on 82 cases by immunohistochemistry and polymerase chain reaction.: Acta Neuropathol (Berl). 1996 Oct;92(4):404-8. Unique Identifier : AIDSLINE MED/97046151; Vago L; Nebuloni M; Sala E; Cinque P; Bonetto S; Isella A; Ottoni L; Crociati A; Costanzi G; Pathology Unit, L. Sacco, Institute of Medical Sciences, University of; Milan, Italy.; We evaluated the frequency and histopathological features of concomitant infections of the central nervous system (CNS) with cytomegalovirus ( CMV ) and herpes simplex viruses type 1 or 2 HSV1/2) in a large series of patients w
Rabies encephalitis in a patient with AIDS: a clinicopathological study.: Acta Neuropathol (Berl). 1996 Oct;92(4):415-20. Unique Identifier : AIDSLINE MED/97046153; Adle-Biassette H; Bourhy H; Gisselbrecht M; Chretien F; Wingertsmann L; Baudrimont M; Rotivel Y; Godeau B; Gray F; Departement de Pathologie (Neuropathologie), Hopital Henri Mondor,; Creteil, France.; A 46-year-old man was bitten by a dog in Mali ; anti-rabies vaccination was incomplete. Three months later he was admitted to hospital with fever and diarrhea. Human immunodeficiency virus HIV) serology was positive and CD4 count was 70/mm3. His status worsened rapidly with confusion
AIDS: biochemical prospectives.: Adv Clin Chem. 1996;32:167-240. Unique Identifier : AIDSLINE MED/97054784; Ghourab G; Memphis Company for Pharmaceutical and Chemical Industries, Amyria; Cairo, Egypt.
Virus-induced immunopathology.: Adv Virus Res. 1996;47:353-76. Unique Identifier : AIDSLINE MED/97051097; Rouse BT; Department of Microbiology, College of Veterinary Medicine, University; of Tennessee, Knoxville 37996, USA.
Geographic and molecular epidemiology of primate T lymphotropic retroviruses: HTLV-I, HTLV-II, STLV-I, STLV-PP, and PTLV-L.: Adv Virus Res. 1996;47:377-426. Unique Identifier : AIDSLINE MED/97051098; Gessain A; de The G; Departement du SIDA et des Retrovirus, Institut Pasteur, Paris,; France.
Preventing perinatal HIV transmission: zidovudine use during pregnancy.: Am Fam Physician. 1997 Jan;55(1):171-4, 177-8. Unique Identifier : AIDSLINE MED/97148709; Carmichael C; Florida AIDS Education and Training Center, Miami Beach, USA.; Human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome in women of childbearing age are increasing rapidly in the United States . Perinatal transmission can occur during pregnancy, delivery or breast feeding. Because 90 percent of pediatric HIV infections ar
Human immunodeficiency virus testing and counseling: nuts and bolts.: Am J Obstet Gynecol. 1996 Dec;175(6):1502-10. Unique Identifier : AIDSLINE MED/97141675; Gupta GK; Division of Infectious Diseases, University of California, Irvine,; Medical Center, Orange 92668, USA.; The human immunodeficiency virus poses an increasing health hazard to women. Physicians must recognize this risk and evaluate their patients for human immunodeficiency virus. Because of general increased awareness and the recommendations that all prenatal patients be offered human immunodeficiency virus testing and co
Peripheral blood CD8- T-cell subsets in common variable immunodeficiency.: Allergy. 1996 Aug;51(8):589-90. Unique Identifier : AIDSLINE MED/97028652; Munoz Bellido FJ; De La Calle A; Monteseirin FJ; Gonzalez J; Gimenez MJ; Conde J; fcojmb@intertex.es
[Immunologic deficiency and pain]: Anaesthesist. 1996 Nov;45(11):1001. Unique Identifier : AIDSLINE MED/97121756; Stein C
[Pain syndromes in AIDS]: Anaesthesist. 1996 Nov;45(11):1004-14. Unique Identifier : AIDSLINE MED/97121758; Wesselmann U; Johns Hopkins University School of Medicine, Department of Neurology,; Blaustein Pain Treatment Center, Baltimore, MD 21287-0873, USA.; Pain is a major, but largely neglected problem in AIDS patients. The aim of this article is to review the etiology of pain manifestations in AIDS patients in different organ systems and to discuss appropriate treatment strategies. The most common pain symptoms in AIDS patients are headache, oral cavity pain, dysphagia
Symptomatology of HIV-related illness and community-acquired illness in an HIV-infected emergency department population.: Ann Emerg Med. 1997 Jan;29(1):151-7. Unique Identifier : AIDSLINE MED/97152163; Hafner JW Jr; Brillman JC; University of New Mexico School of Medicine, Albuquerque, USA.; STUDY HYPOTHESIS: Community-acquired infections and non-AIDS-related illnesses are a significant proportion of the final diagnoses in HIV-infected patients presenting to an emergency department. We hypothesized that emergency physicians over-diagnose opportunistic infections in the HIV-infected patient. We also hypoth
Development of an antipathology vaccine for schistosomiasis.: Ann N Y Acad Sci. 1996 Oct 25;797:191-5. Unique Identifier : AIDSLINE MED/97146506; Wynn TA; Immunobiology Section, National Institutes of Health, Bethesda,; Maryland 20892, USA.; The data presented here clearly demonstrate that IL-12 can act as an adjuvant, suppressing both granuloma formation and fibrosis induced after natural schistosome infection. Recently, we showed that IL-12 can increase protective immunity provided by an attenuated larval schistosome vaccine as well. In both cases the v
Mycobacterium avium infection in a patient with acquired immunodeficiency syndrome and a solid silicone buttock implant.: Ann Plast Surg. 1996 Oct;37(4):411-4. Unique Identifier : AIDSLINE MED/97061004; Kaplan A; Orsetti KE; Kuzon WM Jr; Section of Plastic and Reconstructive Surgery, University of Michigan; Medical School, Ann Arbor 48109-0340, USA.; A 31-year-old female patient with both acquired immunodeficiency syndrome and a solid silicone buttock implant presented with fever. Using ultrasound-guided aspiration of the periprosthetic space, a diagnosis of Mycobacterium avium complex infection involving the implant was made. The implant was surgically removed an
Significantly increased activated T cells are associated with declining CD4 cells in human immunodeficiency virus positive patients.: Ann Acad Med Singapore. 1995 Nov;24(6):785-8. Unique Identifier : AIDSLINE MED/96436095; Dhaliwal JS; Balasubramaniam T; Quek CK; Arumainnathan S; Nasuruddin BA; Division of Immunology, Institute for Medical Research, Kuala Lumpur,; Malaysia.; A cross-sectional study on the expression of 6 lymphocyte markers was carried out on 481 patients with human immunodeficiency virus HIV) and 79 normals after stratification based on absolute CD4 counts. The data were stratified according to the following groups: (I) 1201 to 1600, (II) 801 to 1200, (III) 401 to 800 and
Mutants of feline immunodeficiency virus resistant to 2',3'-dideoxy-2',3'-didehydrothymidine.: Antimicrob Agents Chemother. 1996 Sep;40(9):1983-7. Unique Identifier : AIDSLINE MED/97032819; Zhu YQ; Remington KM; North TW; Division of Biological Sciences, University of Montana, Missoula; 59812, USA.; We selected mutants of feline immunodeficiency virus (FIV) that are resistant to 2 ,3 -dideoxy-2 ,3 -didehydrothymidine ( d4T ). Two mutants were selected in cultured cells with a stepwise increase in d4T concentration, resulting in mutants able to repl
Native oligodeoxynucleotides specifically active against human immunodeficiency virus type 1 in vitro: a G-quartet-driven effect?: Antimicrob Agents Chemother. 1996 Sep;40(9):2034-8. Unique Identifier : AIDSLINE MED/97032828; Tondelli L; Colonna FP; Garbesi A; Zanella S; Marongiu ME; Corrias S; Loi AG; La Colla P; Istituto ICOCEA Consiglia Nazionale delle Ricerche, Bologna, Italy.; Among a series of unmodified phosphodiester PO)-oligodeoxynucleotides (PO-ODNs) complementary to some of the human immunodeficiency virus type 1 (HIV-1) regulatory genes, several PO-ODN sequences complementary to the vpr gene PO-ODNs-a-vpr, where a-vpr is the antisense vpr sequence) emerged as potent inhibitors (at co
Evidence that high-dosage zidovudine at time of retrovirus exposure reduces antiviral efficacy.: Antimicrob Agents Chemother. 1996 Sep;40(9):2183-6. Unique Identifier : AIDSLINE MED/97032855; Mathes LE; Hayes KA; Kociba G; Department of Veterinary Biosciences, Ohio State University, Columbus; 43210, USA.; The antiviral efficacy of prophylactic 3 -azido-3 -deoxythymidine AZT ) therapy administered by continuous infusion or intermittent injection was compared in pediatric cats infected with feline leukemia virus. A 4-week treatment regimen of AZT was init
Novel mutation (K70E) in human immunodeficiency virus type 1 reverse transcriptase confers decreased susceptibility to 9-[2-(phosphonomethoxy)ethyl]adenine in vitro.: Antimicrob Agents Chemother. 1996 Sep;40(9):2212-6. Unique Identifier : AIDSLINE MED/97032863; Cherrington JM; Mulato AS; Fuller MD; Chen MS; Gilead Sciences, Foster City, California 94404, USA.; 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA), an acyclic nucleoside phosphonate analog, is active against several retroviruses and herpesviruses and has shown anti-human immunodeficiency virus (HIV) activity in clinical trials. Serial passage of HIV type 1 (strain IIIb, in MT2 cells in increasing concentrations of PMEA
The effect of recombinant human interferon alpha B/D compared to interferon alpha 2b on SIV infection in rhesus macaques.: Antiviral Res. 1996 Aug;32(1):1-8. Unique Identifier : AIDSLINE MED/97017389; Schellekens H; Niphuis H; Buijs L; Douw van der Krap P; Hochkeppel HK; Heeney JL; Diagnostic Centre SSDZ, Department of Infectious Diseases and; Immunology, The Netherlands.; The model of simian immunodeficiency virus (SIV) infection in rhesus macaques was used to evaluate the effects of recombinant human interferon alpha, Hu IFN-alpha 2b and Hu IFN-gamma B,D, at two doses. Administration began 1 day prior to infection and was continued for 90 days postinfection. Both interferons suppresse
Anti-hepatitis B virus activity of N-acetyl-L-cysteine (NAC): new aspects of a well-established drug.: Antiviral Res. 1996 Aug;32(1):43-53. Unique Identifier : AIDSLINE MED/97017394; Weiss L; Hildt E; Hofschneider PH; Max-Planck-Institut fur Biochemie, Martinsried, Germany.; N-acetyl-L-cysteine (NAC) is commonly administered as an antidote against acetaminophen intoxication and is the preferred agent in the treatment of pulmonary diseases. It is furthermore commonly considered that it restrains human immunodeficiency virus (HIV) replication by scavenging reactive oxygen intermediates (ROI
Lactoferrin inhibits proliferative response and cytokine production of TH1 but not TH2 cell lines.: Arch Immunol Ther Exp (Warsz). 1996;44(1):51-6. Unique Identifier : AIDSLINE MED/97028757; Zimecki M; Mazurier J; Spik G; Kapp JA; Institute of Immunology and Experimental Therapy, Polish Academy of; Sciences, Czerska, Wroclaw, Poland.; Bovine (BLF) and human (HLF) lactoferrin inhibit proliferation and cytokine production by an antigen specific TH1 cell line stimulated with antigen presenting cells (APC) and antigen. Beside the inhibitory effects on TH1 cells we observed a decrease of interleukin 2 receptor (IL-2R) expression on these cells contacted
The spectrum of osteoarticular and soft tissue changes in patients with human immunodeficiency virus (HIV) infection.: Crit Rev Diagn Imaging. 1996 Sep;37(4):305-47. Unique Identifier : AIDSLINE MED/97049670; Tehranzadeh J; O'Malley P; Rafii M; Department of Radiological Sciences, University of California, Irvine; Medical Center, Orange 92868-3298, USA.; In 1995, the World Health Organization reported that 18 million people worldwide have been infected with the human immunodeficiency virus (HIV), with projections that this number will increase to 30 to 40 million by the year 2000. Presently, in the U.S. over 1 million persons are infec
Manipulation of the Th1/Th2 balance in autoimmune disease.: Curr Opin Immunol. 1996 Dec;8(6):837-42. Unique Identifier : AIDSLINE MED/97148232; Nicholson LB; Kuchroo VK; Center For Neurologic Diseases, Brigham and Women's Hospital, Boston,; MA, USA.; Many autoimmune diseases are caused by autopathogenic Th1 cells. Because in vitro Th1 and Th2 cells cross-regulate each other, it is likely that the induction of self-antigen-specific Th2 cells can prevent autoimmune disease. In the past year, investigators have further defined the role of Th1 and Th2 cytokines in the
Urine-based diagnostic technologies.: Trends Biotechnol. 1996 Oct;14(10):361-4. Unique Identifier : AIDSLINE MED/97141289; Urnovitz HB; Murphy WH; Gottfried TD; Friedman-Kien AE; Calypte Biomedical Corporation, Berkeley, CA 94710, USA.; hervdoc@aol.com; The worldwide dissemination of infectious agents has created a demand for simple diagnostic tests. Urine-based testing makes use of non-invasive collection of specimens, and there is no need for expensive facilities and equipment, or for highly trained personnel. As urine antibodies retain activity under normal condit
Evaluation of hepatitis C virus protein epitopes for vaccine development.: Trends Biotechnol. 1996 Oct;14(10):364-9. Unique Identifier : AIDSLINE MED/97141290; Koshy R; Inchauspe G; Department of Virology, Royal Postgraduate Medical School, Hammersmith; Hospital, London, UK. rkoshy@rpms.ac.uk; Infection with hepatitis C virus (HCV) leads to viral persistence and chronic disease in a very high proportion of cases, despite a broad immunological response to viral proteins. These responses may thwarted by the high rate of mutation, which leads to the generation of escape variants of HCV that persist as a quas
Bioinformatics in the pharmaceutical industry.: Trends Biotechnol. 1996 Aug;14(8):308-12. Unique Identifier : AIDSLINE MED/97141120; Lyall A; Glaxo Wellcome Research and Development, Medicines Research Centre,; Stevenage, Hertfordshire, UK. al28044@ggr.co.uk; The great advances in human healthcare that are presaged by the Human Genome Project can be realized by the pharmaceutical industry. A prerequisite for this will be the successful integration of bioinformatics into most aspects of drug discovery. Although, from a scientific viewpoint, this is not a difficult problem,
Quantitative multiple competitive PCR of HIV-1 DNA in a single reaction tube.: Biotechniques. 1996 Sep;21(3):480-4. Unique Identifier : AIDSLINE MED/97033930; Zimmermann K; Schogl D; Plaimauer B; Mannhalter JW; Immuno AG Vienna, Austria.; A quantitative multiple competitive PCR (QMC-PCR) for determination of DNA copy numbers is described. Four competitive DNA templates for the env region of HIV-1 were constructed with sizes longer (187 and 163 bp) or shorter (122 and 105 bp) than the 142 bp of the wild-type PCR product. Varying amounts of each of these
Detection of cell-surface antigens using antibody-conjugated fluorospheres (ACF): application for six-color immunofluorescence.: Biotechniques. 1996 Sep;21(3):498-503. Unique Identifier : AIDSLINE MED/97033933; Beavis AJ; Pennline KJ; Hospital for Special Surgery, New York, NY, USA.; Antibody-conjugated fluorospheres (ACF) were used to phenotype murine leukocytes by flow cytometric analysis. Multicolor immunofluoresence (beyond simultaneous 4-color analysis) is limited by the availability of specific antibody-fluorochrome chrome conjugates and even further restricted by the spectral emission overl
Health care systems in transition: confronting new problems in changing circumstances.: J Public Health Med. 1996 Sep;18(3):254-7. Unique Identifier : AIDSLINE MED/97042632; Beck EJ; Mays N; Department of Epidemiology and Public Health, Imperial College School; of Medicine at St. Mary's, London.
Health care systems in transition: People's Republic of China. Part II: The Chinese health care system's response to HIV-AIDS.: J Public Health Med. 1996 Sep;18(3):266-8. Unique Identifier : AIDSLINE MED/97042634; Kong-Lai Z; Wei C; Department of Epidemiology, Peking Union Medical College, Beijing,; People's Republic of China.
Health care systems in transition: New Zealand. Part II: The New Zealand health care system's response to HIV-AIDS.: J Public Health Med. 1996 Sep;18(3):274-7. Unique Identifier : AIDSLINE MED/97042636; Chetwynd J; Dickson N; Department of Public Health and General Medicine, Christchurch School; of Medicine, New Zealand.
Health care systems in transition: The Netherlands. Part II: The response of the Dutch health care system to HIV-AIDS.: J Public Health Med. 1996 Sep;18(3):285-8. Unique Identifier : AIDSLINE MED/97042638; Danner SA; Clinical AIDS Unit, Academisch Medisch Centrum, Amsterdam, The; Netherlands.
Health care systems in transition: Brazil Part II: The current status of AIDS in Brazil.: J Public Health Med. 1996 Sep;18(3):296-300. Unique Identifier : AIDSLINE MED/97042640; Santos BR; Barcellos NT; Infectious Diseases Service, Hospital Senhora da Conceicao, Porto; Alegre-RS, Brazil.
Quarterly communicable disease review January to March 1996. From the PHLS Communicable Disease Surveillance Centre.: J Public Health Med. 1996 Sep;18(3):364-7. Unique Identifier : AIDSLINE MED/97042650
Perspective: research highlights of the University of Alabama at Birmingham Center for AIDS Research. Paradigm shifts, translational research, and CFARs.: AIDS Res Hum Retroviruses. 1996 Sep 20;12(14):1301-3. Unique Identifier : AIDSLINE MED/97046186; Hunter E; UAB Center for AIDS Research, University of Alabama at Birmingham; 35294-2170, USA.
Characterization of CD4-gp120 activation intermediates during human immunodeficiency virus type 1 syncytium formation.: AIDS Res Hum Retroviruses. 1996 Sep 20;12(14):1305-13. Unique Identifier : AIDSLINE MED/97046187; Hart TK; Truneh A; Bugelski PJ; Department of Toxicology, SmithKline Beecham Pharmaceuticals, King of; Prussia, Pennsylvania 19406, USA.; The mechanism by which cells expressing HIV envelope glycoproteins progress from binding CD4+ cells to syncytia formation is not entirely understood. The purpose of these investigations was to use physical and biochemical tools temperature shifts, soluble CD4, protease
CD4 confers susceptibility to human immunodeficiency virus type 1 infection in a rat fibroblast cell line.: AIDS Res Hum Retroviruses. 1996 Sep 20;12(14):1315-8. Unique Identifier : AIDSLINE MED/97046188; Mizrachi Y; Rubinstein A; Golodner M; Sakai K; Volsky DJ; Department of Pediatrics, Albert Einstein College of Medicine, Bronx,; New York 10461, USA.; A new model system is delineated that will enable study of CD4 cofactors and gp120 binding proteins other than CD4. We have previously described a nontransformed rat fibroblast cell line that can efficiently produce HIV-1 upon transfection with an HIV-1 infectious clone, in contrast to other nonhuman mammalian cell li
Human immunodeficiency virus type 1 neutralizing antibody serotyping using serum pools and an infectivity reduction assay.: AIDS Res Hum Retroviruses. 1996 Sep 20;12(14):1319-28. Unique Identifier : AIDSLINE MED/97046189; Mascola JR; Louder MK; Surman SR; Vancott TC; Yu XF; Bradac J; Porter KR; Nelson KE; Girard M; McNeil JG; McCutchan FE; Birx DL; Burke DS; Division of Retrovirology, Walter Reed Army Institute of Research,; Rockville, Maryland 20850, USA.; Classification of human immunodeficiency virus type 1 (HIV-1) by neutralization serotype may be important for the design of active and passive immunization strategies. Neutralizing antibody serotyping is hindered by the lack of standard reagents and assay format, and by the weak activity of many individual sera. To fa
Full-length sequence of an ethiopian human immunodeficiency virus type 1 (HIV-1) isolate of genetic subtype C.: AIDS Res Hum Retroviruses. 1996 Sep 20;12(14):1329-39. Unique Identifier : AIDSLINE MED/97046190; Salminen MO; Johansson B; Sonnerborg A; Ayehunie S; Gotte D; Leinikki P; Burke DS; McCutchan FE; Henry M. Jackson Foundation for the Advancement of Military Medicine,; Rockville, Maryland 20850, USA.; Genetic subtype C of the human immunodeficiency virus type-1 HIV-1) has established foci of infection in India and in at least eight African countries, and is expected to contribute significantly to the global pandemic. Here we report the first almost full-length sequence of a subty
Titration of a vaccine stock preparation of human immunodeficiency virus type 1SF2 in cultured lymphocytes and in chimpanzees.: AIDS Res Hum Retroviruses. 1996 Sep 20;12(14):1341-8. Unique Identifier : AIDSLINE MED/97046191; Murthy KK; Cobb EK; el-Amad Z; Ortega H; Hsueh FC; Satterfield W; Lee DR; Kalish ML; Haigwood NL; Kennedy RC; Steimer KS; Schultz A; Levy JA; Department of Virology and Immunology, Southwest Foundation for; Biomedical Research, San Antonio, Texas 78245, USA.; A large stock preparation of the HIV-1SF2 isolate has been derived after serial passage in human peripheral blood mononuclear cells (PBMCs). This viral stock has a titer of 10(4.9) TCID50 in human PBMCs and 10(4.2) TCID50 in chimpanzee PBMCs. By inoculation into animals the 50% chimpanzee infectious dose titer was fou
Transcriptional up-regulation of interleukin 4 receptors by human immunodeficiency virus type 1 tat gene.: AIDS Res Hum Retroviruses. 1996 Sep 20;12(14):1349-59. Unique Identifier : AIDSLINE MED/97046192; Husain SR; Leland P; Aggarwal BB; Puri RK; Laboratory of Molecular Tumor Biology, FDA, Bethesda, Maryland 20892,; USA.; The human immunodeficiency virus type 1 (HIV-1) regulatory gene, tat, encodes an early transactivator protein (Tat) necessary for virus replication. We have reported that the HIV-1 tat gene can up-regulate interleukin 4 receptors (IL-4R) however, the mechanism of this up-regulation is not understood. We now show that
Role of protein kinase C-beta isozyme in activation of latent human immunodeficiency virus type 1 in promonocytic U1 cells by phorbol-12-myristate acetate.: AIDS Res Hum Retroviruses. 1996 Sep 20;12(14):1361-6. Unique Identifier : AIDSLINE MED/97046193; Kim CH; Gollapudi S; Kim A; Lee T; Gupta S; Department of Medicine, University of California, Irvine 92717, USA.; Protein kinase C (PKC) appears to play a role in replication of human immunodeficiency virus type 1 (HIV-1). PKC is a family of at least 12 isozymes. In this study, we investigated a role of Ca(2+)-dependent PKC isozymes (alpha, beta, and gamma) in activation of latent HIV-1 in U1, a chronically infected promonocytic
Biochemical characterization of the reverse transcriptase of a human intracisternal A-type particle (HIAP).: AIDS Res Hum Retroviruses. 1996 Sep 20;12(14):1367-72. Unique Identifier : AIDSLINE MED/97046194; Hart DJ; Luo H; Garry RF; Department of Psychiatry and Neurology, Tulane University School of; Medicine, New Orleans, Louisiana 70112-2699, USA.; The discovery of novel human intracisternal A-type particle HIAP) that may be associated with the autoimmune disease Sjogren s syndrome has been previously reported. Although the HIAP retrovirus has been shown to be antigenically related to HIV-1, the viruses were distinguishable by different hydrodynamic mobilities t
Inhibition of murine AIDS by reduced glutathione.: AIDS Res Hum Retroviruses. 1996 Sep 20;12(14):1373-81. Unique Identifier : AIDSLINE MED/97046195; Palamara AT; Garaci E; Rotilio G; Ciriolo MR; Casabianca A; Fraternale A; Rossi L; Schiavano GF; Chiarantini L; Magnani M; Department of Experimental Medicine, University of Rome Tor Vergata,; Italy.; The imbalance of the redox state in cells and body fluids in HIV-1-infected patients may result in progression of the disease as well as in immunologic disfuctions. In this report, we have evaluated whether the direct administration of high doses of reduced glutathione (GSH) exerts any antiviral activity and/or improv
Rapid sequon evolution in human immunodeficiency virus type 1 relative to human immunodeficiency virus type 2.: AIDS Res Hum Retroviruses. 1996 Sep 20;12(14):1383-4. Unique Identifier : AIDSLINE MED/97046196; Wills C; Farmer A; Myers G; Department of Biology, University of California, San Diego, La Jolla; 92093-0116, USA.
Sequence analysis of the glycoprotein 120 coding region of a new human immunodeficiency virus type 1 subtype G strain from Russia.: AIDS Res Hum Retroviruses. 1996 Sep 20;12(14):1385-8. Unique Identifier : AIDSLINE MED/97046197; Bobkov A; Cheingsong-Popov R; Karasyova N; Selimova L; Kravchenko A; Bochkova M; Kazennova E; Ladnaya N; Pokrovsky V; Weber J; D.I. Ivanovsky Institute of Virology, Moscow, Russia.
Genetic variability of human immunodeficiency virus type 1 in rural northwest Tanzania.: AIDS Res Hum Retroviruses. 1996 Sep 20;12(14):1389-91. Unique Identifier : AIDSLINE MED/97046198; Robbins KE; Bandea CI; Levin A; Goedert JJ; Blattner WA; Brubaker G; Brown TM; Schochetman G; Kalish ML; Shao J; O'Brien TR; Division of AIDS, Sexually Transmitted Diseases, Centers for Disease; Control and Prevention, Atlanta, Georgia 30333, USA.
Perspective: research highlights at the Medical College of Wisconsin's Center for AIDS Intervention Research. Advances in HIV primary and secondary prevention.: AIDS Res Hum Retroviruses. 1996 Oct 10;12(15):1393-5. Unique Identifier : AIDSLINE MED/97048210; Kelly JA; Department of Psychiatry and Behavioral Medicine, Medical College of; Wisconsin, Milwaukee 53226, USA.
Mother-to-infant transmission of HIV type 1: role of major histocompatibility antigen differences.: AIDS Res Hum Retroviruses. 1996 Oct 10;12(15):1397-400. Unique Identifier : AIDSLINE MED/97048211; Mittleman BB; Shearer GM; Experimental Immunology Branch, National Cancer Institute/NIH,; Bethesda, Maryland 20892, USA.
Covariability of V3 loop amino acids.: AIDS Res Hum Retroviruses. 1996 Oct 10;12(15):1401-11. Unique Identifier : AIDSLINE MED/97048212; Bickel PJ; Cosman PC; Olshen RA; Spector PC; Rodrigo AG; Mullins JI; Department of Statistics, University of California, Berkeley; 94720-3860, USA.; We reanalyzed for covariability a set of 308 human immunodeficiency virus type 1 (HIV-1) V3 loop amino acid sequences from the B envelope sequence subtype previously analyzed by Korber et al.,1 as well as a new set of 440 sequences that also included substantial numbers of sequences from subtypes A, D, and E. We used
Genomic structure and nucleotide sequence analysis of a new HIV type 1 subtype A strain from Nigeria.: AIDS Res Hum Retroviruses. 1996 Oct 10;12(15):1413-25. Unique Identifier : AIDSLINE MED/97048213; Howard TM; Rasheed S; Laboratory of Viral Oncology, and AIDS Research, University of; Southern California, School of Medicine, Los Angeles 90032-3626, USA.; We have isolated and characterized a new HIV-1 variant HIV-1IbNg) from the peripheral blood mononuclear cells (PBMCs) of an inhabitant of Nigeria . This virus is highly cytopathic to PBMCs in culture, replicates in primary human T cells and macrophages/monocytes as well as in estab
HIV type 1 diversity in northern Paris, France.: AIDS Res Hum Retroviruses. 1996 Oct 10;12(15):1427-33. Unique Identifier : AIDSLINE MED/97048214; Simon F; Loussert-Ajaka I; Damond F; Saragosti S; Barin F; Brun-Vezinet F; Laboratoire de Virologie, Hopital Bichat, Paris, France.; During a 6-month period, we studied the diversity of HIV-1 subtypes in 392 adult patients seen in Bichat-Claude Bernard Hospital, northern Paris, France . All the samples were serotyped and a subset was genotyped by means of HMA. Serotyping was performed with a new peptide subtype-s
Detection of HIV type 1 env subtypes A, B, C, and E in Asia using dried blood spots: a new surveillance tool for molecular epidemiology.: AIDS Res Hum Retroviruses. 1996 Oct 10;12(15):1435-41. Unique Identifier : AIDSLINE MED/97048215; Cassol S; Weniger BG; Babu PG; Salminen MO; Zheng X; Htoon MT; Delaney A; O'Shaughnessy M; Ou CY; Department of Medicine, Ottawa General Hospital, Ontario, Canada.; Global surveillance of HIV-1 subtypes for genetic characterization is hampered by the biohazard of processing and the difficulties of shipping whole blood or cells from many developing country regions. We developed a technique for the direct automated sequencing of viral DNA from dried blood spot DBS) specimens collec
Analysis of human immunodeficiency virus type 1 mRNA splicing patterns during disease progression in peripheral blood mononuclear cells from infected individuals.: AIDS Res Hum Retroviruses. 1996 Oct 10;12(15):1443-56. Unique Identifier : AIDSLINE MED/97048216; Saltarelli MJ; Hadziyannis E; Hart CE; Harrison JV; Felber BK; Spira TJ; Pavlakis GN; Retrovirus Disease Branch, Centers for Disease Control and Prevention,; Atlanta, Georgia 30333, USA.; HIV-1 produces more than 20 mRNAs encoding the viral proteins. We have used a sensitive reverse transcriptase-polymerase chain reaction (RT-PCR) approach to determine HIV-1 transcriptional patterns during the course of viral infection in unstimulated peripheral blood mononuclear cells (PBMCs) from different patients.
Abnormal expression of a 170-kilodalton P-glycoprotein encoded by MDR1 gene, a metabolically active efflux pump, in CD4+ and CD8+ T cells from patients with human immunodeficiency virus type 1 infection.: AIDS Res Hum Retroviruses. 1996 Oct 10;12(15):1457-62. Unique Identifier : AIDSLINE MED/97048217; Andreana A; Aggarwal S; Gollapudi S; Wien D; Tsuruo T; Gupta S; Division of Basic and Clinical Immunology, University of California,; Irvine 92717-4069, USA.; Peripheral blood CD4+ and CD8+ T cells from 16 patients with HIV-1 infection, 8 each with CD4+ T cell counts of > 200/mm3 group I) and with CD4+ T cell counts of
A natural sulfated polysaccharide, calcium spirulan, isolated from Spirulina platensis: in vitro and ex vivo evaluation of anti-herpes simplex virus and anti-human immunodeficiency virus activities.: AIDS Res Hum Retroviruses. 1996 Oct 10;12(15):1463-71. Unique Identifier : AIDSLINE MED/97048218; Hayashi K; Hayashi T; Kojima I; Department of Virology, Toyama Medical and Pharmaceutical University,; Japan.; A sulfated polysaccharide named calcium spirulan (Ca-SP) has been isolated from a sea alga, Spirulina platensis, as an antiviral component. The anti-human immunodeficiency virus type 1 (HIV-1) and anti-herpes simplex virus type 1 (HSV-1) activities of Ca-SP were compared with those of dextran sulfate (DS) as a represe
No evidence of antibody to human foamy virus in widespread human populations.: AIDS Res Hum Retroviruses. 1996 Oct 10;12(15):1473-83. Unique Identifier : AIDSLINE MED/97048219; Ali M; Taylor GP; Pitman RJ; Parker D; Rethwilm A; Cheingsong-Popov R; Weber JN; Bieniasz PD; Bradley J; McClure MO; Department of Genito-Urinary Medicine, and Communicable Diseases,; Jefferiss Research Trust Laboratories, Imperial College School of; Medicine at St. Mary's London, UK.; The first human foamy virus (HFV) to be described was isolated from nasopharyngeal carcinoma tissue from a Kenyan patient. Early seroepidemiology concluded that there was a significant infection rate, particularly among Africans. Awareness of foamy viruses as potential vectors has stimulated interest in the natural se
Inhibition of the in vitro infectivity and cytopathic effect of human foamy virus by dideoxynucleosides.: AIDS Res Hum Retroviruses. 1996 Oct 10;12(15):1485-90. Unique Identifier : AIDSLINE MED/97048220; Santillana-Hayat M; Valla J; Canivet M; Peries J; Molina JM; UPR A0043 CNRS, Retrovirus et Retrotransposons des Vertebres, Hopital; Saint-Louis, Paris, France.; Human foamy virus (HFV) is a human retrovirus that has not been clearly associated with human disease. In this study, we tested the capacity of nucleoside derivatives to inhibit the infectivity and cytopathic effect of HFV in T-lymphoblastoid cells in vitro. H9 cells showed a dramatic cytopathic effect 3 weeks after e
Genetic analysis of V3 domain sequences obtained from Uruguayan HIV type 1-infected individuals.: AIDS Res Hum Retroviruses. 1996 Oct 10;12(15):1491-3. Unique Identifier : AIDSLINE MED/97048221; Fernandez Medina RD; Jansson M; Halapi E; Russi JC; Libonatti O; Wigzell H; Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm,; Sweden.
Genetic variability of HIV type 1 in Benin.: AIDS Res Hum Retroviruses. 1996 Oct 10;12(15):1495-7. Unique Identifier : AIDSLINE MED/97048222; Heyndrickx L; Janssens W; Alary M; Fransen K; Vereecken K; Coppens S; Willems B; Davo N; Guedeme A; Baganizi E; Joly J; Van der Groen G; Department of Microbiology, Institute of Tropical Medicine, Antwerp,; Belgium.
Stenotrophomonas africana sp. nov., an opportunistic human pathogen in Africa [published erratum appears in Int J Syst Bacteriol 1997 Apr;47(2):606]: Int J Syst Bacteriol. 1997 Jan;47(1):160-3. Unique Identifier : AIDSLINE MED/97148994; Drancourt M; Bollet C; Raoult D; Unite des Rickettsies CNRS EP J0054, Faculte de Medicine, Marseille,; France.; A gram-negative bacterium was isolated from a cerebrospinal fluid sample from an HIV-seropositive Rwandan refugee with primary meningoencephalitis. This Marseille-Goma sample B isolate, strain MGBT (T = type strain), was found to exhibit evolutionary homology with Stenotrophomonas maltophilia, as determined by a 16S r
Evidence for down-regulation of highly expressed TCR by CD4 and CD45 on non-selected CD4+CD8+ thymocytes.: Int Immunol. 1996 Oct;8(10):1529-35. Unique Identifier : AIDSLINE MED/97079721; Sato T; Hozumi K; Kishihara K; Kametani Y; Sato C; Kumagai Y; Mak TW; Habu S; Department of Immunology, Tokai University School of Medicine,; Kanagawa, Japan.; Immature CD4+CD8+ double-positive (DP) thymocytes are positively selected for further development if they express TCR reacting with thymic ligands of low affinity. However, the majority of DP thymocytes express low TCR levels. This low level of TCR may be insufficient to recognize thymic ligands. To understand the bas
Linomide, an immunomodulator that inhibits Th1 cytokine gene expression.: Int Immunol. 1996 Oct;8(10):1603-7. Unique Identifier : AIDSLINE MED/97079729; Arad G; Katzenellenbogen M; Levy R; Slavin S; Kaempfer R; Department of Molecular Virology, Hebrew University-Hadassah Medical; School, Jerusalem, Israel.; Linomide (LS-2616, quinoline-3-carboxamide) has strong immunomodulating effects in animal models, inhibiting toxic shock, progressive autoimmune disease and cancer. In humans, linomide strongly reduced the appearance of new lesions in multiple sclerosis yet enhanced immune responses after bone marrow transplantation.
Impairment of force generation after adenovirus-mediated gene transfer to muscle is alleviated by adenoviral gene inactivation and host CD8+ T cell deficiency.: Hum Gene Ther. 1996 Oct 1;7(15):1813-26. Unique Identifier : AIDSLINE MED/97049945; Petrof BJ; Lochmuller H; Massie B; Yang L; Macmillan C; Zhao JE; Nalbantoglu J; Karpati G; Department of Medicine, Royal Victoria Hospital, Montreal, Quebec,; Canada.; Recombinant adenovirus vectors (AdV) hold promise as a means of delivering therapeutic genes to muscle in diseases such as Duchenne muscular dystrophy (DMD). However, we have previously shown that the use of AdV is hampered by the development of reduced force-generating capacity, which occurs within 1 week and is prog
Intracellular expression of cellular eIF-5A mutants inhibits HIV-1 replication in human T cells: a feasibility study.: Hum Gene Ther. 1996 Oct 1;7(15):1861-9. Unique Identifier : AIDSLINE MED/97049950; Junker U; Bevec D; Barske C; Kalfoglou C; Escaich S; Dobrovnik M; Hauber J; Bohnlein E; Progenesys program at Systemix, Palo Alto, CA 94304.; Previously, we described two mutants of the cellular Rev co-factor, eukaryotic initiation factor 5A (eIF-5A M13 and M14), which suppress human immunodeficiency virus type 1 (HIV-1) SF2 replication in clonal T cell lines. This study introduced the notion that it is possible to develop gene therapies against infectious
Quantitative analysis of T lymphocyte subsets in pregnant and nonpregnant human endometrium.: Biol Reprod. 1996 Nov;55(5):1017-22. Unique Identifier : AIDSLINE MED/97057882; Vassiliadou N; Bulmer JN; Department of Pathology, University of Newcastle upon Tyne, Royal; Victoria Infirmary, United Kingdom.; neratzoula.vassiliadou@newcastle.ac.uk; The purpose of this study was to characterize and quantify T lymphocyte populations and to investigate T cell antigen receptor TcR) expression in human endometrium throughout the menstrual cycle and in early pregnancy. Frozen sections of endometrium were labeled using the highly sensitive avidinbiotin method and a pan
[Thoracic tuberculosis in adults. A comparative study of radiological findings of HIV seropositive and seronegative patients]: An Med Interna. 1996 Oct;13(10):476-82. Unique Identifier : AIDSLINE MED/97150139; Sanchez Nistal MA; Gallego Gallego MS; Manrique Chico J; Lopez pino MA; Paul Diaz L; Servicio de Radiodiagnostico, Hospital 12 de Octubre, Madrid.; We compare the radiologic manifestations of chest TB in three groups of patients: HIV patients (52 cases), HIV negative patients (85 cases and 100 cases). Initial radiologic findings were similar in the two seronegative groups, even though there is an eight-year interval between both series. However, seropositive pati
[Adult respiratory distress syndrome caused by miliary tuberculosis in a patient with HIV infection (letter)]: An Med Interna. 1996 Oct;13(10):511. Unique Identifier : AIDSLINE MED/97150148; Arbol Linde F; Marcos Sanchez F; Contreras Rosino C; Juan Sarmiento E; Lopez Onega P
[HIV infection and lymphomatous meningitis]: An Med Interna. 1996 Nov;13(11):541-3. Unique Identifier : AIDSLINE MED/97144817; Valencia ME; Moreno V; Martinez P; Gonzalez Lahoz J; Servicio de Enfermedades Infecciosas, Instituto de Salud Carlos III,; Madrid.; Lymphomatous meningitis and lymphoma confined to the central nervous system are the most serious neurological diseases in patients with human immunodeficiency virus infection. The diagnosis is difficult and it is usually done with advanced systemic disease or when the chemotherapy is finished. During a ten month perio
Differential involvement of Th1 and Th2 cytokines in autoimmune diseases.: Autoimmunity. 1996;24(1):25-33. Unique Identifier : AIDSLINE MED/97092020; Kroemer G; Hirsch F; Gonzalez-Garcia A; Martinez C; CNRS-UPR420, Villejuif, France.; By virtue of their functional antagonism, Th1 cells or cells producing the same cytokines as Th1 cells may behave as suppressor cells with respect to Th2 cells and vice versa. An excessive Th1- or Th2-like response may favor the development of different autoimmune diseases. As can be expected from their physiological
Thyroid-specific T cells in the Wistar rat: 3. Induction of anergy by a syngeneic thyroid cell line.: Autoimmunity. 1996;24(1):47-53. Unique Identifier : AIDSLINE MED/97092022; Kimura H; Davies TF; Department of Medicine, Mount Sinai School of Medicine, New York, New; York 10029, USA.; Using a syngeneic Wistar rat model we have shown that the Wistar rat thyroid (WRT) cell line causes significant and specific proliferation of lymph node T cells from normal Wistar rats, and of splenic T cells from a thyroiditis prone line of BB/W rats, when cultured in the presence of irradiated feeder cells. These T
Relationship of regional wall motion abnormalities detected by biplane transesophageal echocardiography and electrocardiographic changes in patients undergoing coronary artery bypass graft surgery.: J Cardiothorac Vasc Anesth. 1996 Oct;10(6):719-27. Unique Identifier : AIDSLINE MED/97066674; Koide Y; Keehn L; Nomura T; Long T; Oka Y; Department of Anesthesiology, Albert Einstein College of; Medicine/Montefiore Medical Center, Bronx, NY, USA.; BACKGROUND: It has been demonstrated that new regional wall motion abnormalities (RWMAs) are infrequently associated with electrocardiographic (ECG) ischemic changes during coronary artery bypass graft (CABG) surgery. The evaluation of apical or basal areas by biplane transesophageal echocardiography (TEE) may clarify
Intestinal microsporidiosis in Italian individuals with AIDS.: Ital J Gastroenterol. 1996 Sep;28(7):381-6. Unique Identifier : AIDSLINE MED/97092274; Voglino MC; Donelli G; Rossi P; Ludovisi A; Rinaldi V; Goffredo F; Paloscia R; Pozio E; Laboratorio di Ultrastrutture, Universita La Sapienza, Roma, Italy.; A survey on microsporidiosis in individuals with AIDS presenting chronic diarrhoea was carried out in Italy , over a four-year period (1992-1995). Three out of 72 (4.2%) individuals were found positive, on intestinal biopsies, for Ent
Treatment of "problematic" hepatitis C patients.: Ital J Gastroenterol. 1996 Sep;28(7):393-5. Unique Identifier : AIDSLINE MED/97092277; Colombo M; Istituto di Medicina Interna, Universita degli Studi di Milano, Italy.; There is limited information about the natural history of hepatitis C in problematic patients and this may affect development of treatment strategies. In patients with persistently normal serum transaminases, infection is often a benign condition which does not require therapy. By contrast, treatment with antiviral dr
Mandatory HIV testing in newborns: not yet, maybe never.: J Clin Ethics. 1996 Summer;7(2):191-2. Unique Identifier : AIDSLINE MED/97044824; Davis DS; Cleveland-Marshall College of Law, Cleveland State University, Ohio,; USA.
In vitro metabolism of a potent HIV-protease inhibitor (141W94) using rat, monkey and human liver S9.: Rapid Commun Mass Spectrom. 1996;10(9):1019-26. Unique Identifier : AIDSLINE MED/96298219; Singh R; Chang SY; Taylor LC; Glaxo Wellcome Inc., Research Triangle Park, NC 27709, USA.; Compound 141W94 (Vertex VX478) (3S)-tetrahydro-3-furyl N-[((S,2R)-3-(4-amino-N-isobutylbenzenesulfonamido)-1-benzyl- 2-hydroxypropyl] carbamate, is a potent HIV-protease inhibitor and is currently undergoing clinical trials. The purpose of this study was the rapid identification of the phase I and II in vitro metaboli
Modulation of 5-fluorouracil resistance in human colon tumor cell lines by azidothymidine.: Oncol Res. 1996;8(5):189-96. Unique Identifier : AIDSLINE MED/97039259; Findenig G; Mader RM; Fritzer-Szekeres M; Steger GG; Jaeger W; Szekeres T; Institute for Medical Chemistry, University of Vienna, School of; Medicine, Austria.; 5-fluorouracil (5-FU), an inhibitor of thymidylate synthase (EC 2.1.1.45), is clinically used in the treatment of several solid tumors, including colorectal, head and neck, gastric, and pancreatic cancer. The drug effectively inhibits deoxynucleoside triphosphate de novo synthesis. However, this inhibition can be circ
The choice of plasma-derived clotting factor concentrates.: Baillieres Clin Haematol. 1996 Jun;9(2):273-90. Unique Identifier : AIDSLINE MED/96393732; Mannucci PM; University of Milan, Italy.; The gloomy picture caused by the AIDS epidemic is now partially lightened by spectacular improvements in therapy. One important step forward toward elimination of the risk of transfusion of blood-borne infections by plasma products was the development of virucidal methods and their application to clotting factor conce
Transfusion-transmitted disease.: Baillieres Clin Haematol. 1996 Jun;9(2):369-94. Unique Identifier : AIDSLINE MED/96393738; Lee CA; Haemophilia Centre & Haemostasis Unit, Royal Free Hospital NHS Trust,; Hampstead, London, UK.; Many patients with haemophilia are infected with viruses, due to treatment with blood products--particularly from large pool clotting factor concentrates before 1985. AIDS in haemophilic patients was first described in 1982 and it has significantly reduced the life expectancy of these patients. Although no new sero-co
Expanding spectrum of HTLV-1-related diseases: implications in understanding the mechanisms of viral pathogenesis [editorial; comment]: Intern Med. 1996 Sep;35(9):677-8. Unique Identifier : AIDSLINE MED/97072942; Watanabe T
A human T-cell lymphotropic virus type-I carrier with chronic renal failure, aplastic anemia, myelopathy, uveitis, Sjogren's syndrome and panniculitis [see comments]: Intern Med. 1996 Sep;35(9):742-5. Unique Identifier : AIDSLINE MED/97072956; Osato M; Yamaguchi K; Tamiya S; Yamasaki H; Okubo T; Suzushima H; Asou N; Sakata K; Kawakita M; Takatsuki K; Second Department of Internal Medicine, Kumamoto University School of; Medicine.; A 53-year-old female infected with human T lymphotropic virus type-I (HTLV-I) suffered from chronic renal failure, aplastic anemia, myelopathy, uveitis, Sjogren s syndrome and Weber-Christian disease. Although HTLV-I antibody was negative in cerebrospinal fluid, she was diagnosed as HTLV-I associated myelopathy/tropic
Underestimation and undertreatment of pain in HIV disease: multicentre study.: BMJ. 1997 Jan 4;314(7073):23-8. Unique Identifier : AIDSLINE MED/97154761; Larue F; Fontaine A; Colleau SM; Institut Mutualiste Montsouris, Paris, France.; OBJECTIVE: To measure the prevalence, severity, and impact of pain on quality of life for HIV patients; to identify factors associated with undertreatment of pain. DESIGN: Multicentre cross sectional survey. SETTINGS: 34 HIV treatment facilities, including inpatient hospital wards, day hospitals, and ambulatory care c
Midwives can help increase uptake of antenatal screening for HIV [letter; comment]: BMJ. 1997 Jan 4;314(7073):71. Unique Identifier : AIDSLINE MED/97154779; Killick SR; Craske J; Miller E
Distribution of human leukocyte antigens in a population of black patients with human T-cell lymphotrophic virus type I-associated adult T-cell leukemia/lymphoma.: Cancer Epidemiol Biomarkers Prev. 1996 Nov;5(11):873-7. Unique Identifier : AIDSLINE MED/97080959; White JD; Johnson JA; Nam JM; Cranston B; Hanchard B; Waldmann TA; Manns A; Metabolism Branch, National Cancer Institute, NIH, Bethesda, Maryland; 20892, USA.; Human leukocyte antigens (HLAs) play an important role in regulating the immune response to infectious agents and determinants of malignant transformation. We compared the HLA frequencies of 25 black patients with adult T-cell leukemia/lymphoma (ATL) referred to the National Cancer Institute for therapy with a raciall
HIV/AIDS electronic information resources: a profile of potential users.: Bull Med Libr Assoc. 1996 Oct;84(4):579-81. Unique Identifier : AIDSLINE MED/97070637; Huber JT; Giuse NB; Active Digital Library, Eskind Biomedical Library, Vanderbilt; University Medical Center, Nashville, Tennessee 37232, USA.
[Preliminary screening for antiviral AIDS drugs. IV. Report on fiscal year 1992]: Eisei Shikenjo Hokoku. 1994;(112):131-3. Unique Identifier : AIDSLINE MED/97007655; Sekine H; Ohnuki N; Sadamasu K; Ohta K; Terayama T; Kobayashi N; Noguchi Y; Matsuyama M; Akiyoshi K; Noro S; Preliminary screening of antiviral AIDS drugs has been carried out using three different in vitro assay systems. Among 191 samples tested, seven were found to inhibit the growth of HIV in vitro. Four of seven have hopeful signs, as the ranges of effective doses of the samples are wide.
World AIDS Day, 1 December 1996.: Commun Dis Rep CDR Wkly. 1996 Nov 29;6(48):417, 420. Unique Identifier : AIDSLINE MED/97144885
Comorbidity and survival in HIV-infected men in the San Francisco Men's Health Survey.: Ann Epidemiol. 1996 Sep;6(5):420-30. Unique Identifier : AIDSLINE MED/97072708; Page-Shafer K; Delorenze GN; Satariano WA; Winkelstein W Jr; Department of Epidemiology and Biostatistics, University of California; San Francisco 94105, USA.; The course of disease associated with infection with the human immunodeficiency virus varies widely. Some patients deteriorate rapidly, while others live for years, even after an illness that defines the acquired immunodeficiency syndrome (AIDS). In this study, comorbidity, or the presence of concurrent health problem
Neurotoxicity in rat cortical cells caused by N-methyl-D-aspartate (NMDA) and gp120 of HIV-1: induction and pharmacological intervention.: Prog Mol Subcell Biol. 1996;16:44-57. Unique Identifier : AIDSLINE MED/96420092; Muller WE; Pergande G; Ushijima H; Schleger C; Kelve M; Perovic S; Institut fur Physiologische Chemie, Abteilung Angewandte; Molekularbiologie, Universitat, Duesbergweg, Mainz, Germany.; Incubation of highly enriched neurons from rat cerebral cortex with the human immunodeficiency virus type 1 (HIV-1) coat protein gp120 for 18 h results in fragmentation of DNA at internucleosomal linkers, a feature of apoptosis. We report that neurons respond to exposure to gp120 with an increased release of arachidon
Apoptosis of mature T lymphocytes: putative role in the regulation of cellular immune responses and in the pathogenesis of HIV infection.: Prog Mol Subcell Biol. 1996;16:58-71. Unique Identifier : AIDSLINE MED/96420093; Kabelitz D; Pohl T; Oberg HH; Pechhold K; Dobmeyer T; Rossol R; Paul-Ehrlich-Institute, Langen, Germany.; In this chapter, some aspects of programmed cell death, or apoptosis, of T lymphocytes are discussed. It has been recognized that transformed T cells and immature T lymphocytes can be triggered to undergo apoptosis. As in other cell systems, apoptosis is characterized by cell shrinkage, nuclear condensation, and DNA f
Effect of clarithromycin on lymphocytes in chronic respiratory Pseudomonas aeruginosa infection.: Am J Respir Crit Care Med. 1997 Jan;155(1):337-42. Unique Identifier : AIDSLINE MED/97154615; Yanagihara K; Tomono K; Sawai T; Hirakata Y; Kadota J; Koga H; Tashiro T; Kohno S; Second Department of Internal Medicine, Nagasaki University School of; Medicine, Japan.; In a newly established murine model of chronic Pseudomonas aeruginosa respiratory infection mimicking diffuse panbronchiolitis (DPB), we investigated the effect of oral administration of clarithromycin on lymphocyte accumulation in the lung. Infection was produced by placement of a plastic tube precoated with P. aerug
Alveolar fluid glutathione is not reduced in asymptomatic HIV-seropositive subjects.: Am J Respir Crit Care Med. 1997 Jan;155(1):374-7. Unique Identifier : AIDSLINE MED/97154621; Pacht ER; Diaz P; Clanton T; Hart J; Gadek JE; Department of Internal Medicine, Ohio State University Medical Center,; Columbus, USA.; Glutathione is an important antioxidant tripeptide that is found in high concentrations in the epithelial lining fluid (ELF) of the lung. Previous investigators demonstrated a deficiency of glutathione (GSH) in the epithelial lining fluid of human immunodeficiency virus (HIV)-seropositive patients. The current investi
Testing for human immunodeficiency virus infection among tuberculosis patients in Los Angeles.: Am J Respir Crit Care Med. 1997 Jan;155(1):378-81. Unique Identifier : AIDSLINE MED/97154622; Asch SM; London AS; Barnes PF; Gelberg L; Division of General Internal Medicine, Pacific Center for Health; Policy and Ethics, University of Southern California School of; Medicine, Los Angeles, USA.; To investigate patterns of testing for human immunodeficiency virus (HIV) infection in tuberculosis patients, we obtained data from the tuberculosis registry and from medical records of 500 tuberculosis patients in Los Angeles County. Sixty-three percent of tuberculosis patients were tested for HIV infection, and mult
Predictors of Pneumocystis carinii pneumonia in HIV-infected persons. Pulmonary Complications of HIV Infection Study Group.: Am J Respir Crit Care Med. 1997 Jan;155(1):60-6. Unique Identifier : AIDSLINE MED/97154572; Stansell JD; Osmond DH; Charlebois E; LaVange L; Wallace JM; Alexander BV; Glassroth J; Kvale PA; Rosen MJ; Reichman LB; Turner JR; Hopewell PC; University of California, San Francisco and Los Angeles, USA.; The Pulmonary Complications of HIV Infection Study is a prospective, multicenter, observational study evaluating pulmonary disease among HIV-infected persons. For approximately 52 mo, 1,182 HIV-infected subjects were followed. All participants were evaluated for pulmonary disease on a predetermined schedule. There wer
Intensive care of patients with HIV infection: utilization, critical illnesses, and outcomes. Pulmonary Complications of HIV Infection Study Group.: Am J Respir Crit Care Med. 1997 Jan;155(1):67-71. Unique Identifier : AIDSLINE MED/97154573; Rosen MJ; Clayton K; Schneider RF; Fulkerson W; Rao AV; Stansell J; Kvale PA; Glassroth J; Reichman LB; Wallace JM; Hopewell PC; Department of Medicine, Beth Israel Medical Center, New York, New York; 10003, USA.; To examine intensive care unit (ICU) admission rates and diagnoses of patients with HIV infection, and to determine the outcomes of different critical illnesses, we analyzed data derived from the 63 patients who were admitted to an ICU from among the 1,130 adults with HIV infection who did not have AIDS at the time of
Respiratory disease trends in the Pulmonary Complications of HIV Infection Study cohort. Pulmonary Complications of HIV Infection Study Group.: Am J Respir Crit Care Med. 1997 Jan;155(1):72-80. Unique Identifier : AIDSLINE MED/97154574; Wallace JM; Hansen NI; Lavange L; Glassroth J; Browdy BL; Rosen MJ; Kvale PA; Mangura BT; Reichman LB; Hopewell PC; Department of Medicine, Olive View-UCLA Medical Center, Sylmar,; California 91342, USA.; We examined trends in the incidence of specific respiratory disorders in a multicenter cohort with progressive human immunodeficiency virus (HIV) disease during a 5-yr period. Individuals with a wide range of HIV disease severity belonging to three transmission categories were evaluated at regular intervals and for ep
Two-step tuberculin skin testing in HIV-infected persons in Uganda.: Am J Respir Crit Care Med. 1997 Jan;155(1):81-6. Unique Identifier : AIDSLINE MED/97154575; Hecker MT; Johnson JL; Whalen CC; Nyole S; Mugerwa RD; Ellner JJ; Department of Medicine, Case Western Reserve University and University; Hospitals of Cleveland, Ohio 44106-4984, USA.; Identifying persons infected with both human immunodeficiency virus (HIV) and Mycobacterium tuberculosis (MTB) is often difficult because of the reduced sensitivity of tuberculin skin testing in HIV-infected persons. To determine the value of two-step tuberculin skin testing (TTST) as a method of increasing the sensit
[Can we improve the prevention of tuberculosis? Analysis of the application of chemoprophylaxis]: Arch Bronconeumol. 1996 Dec;32(10):505-9. Unique Identifier : AIDSLINE MED/97163828; Franco Serrano J; Blanquer Olivas R; Flores Cid J; Dominguez Martinez A; Nogueira Coito JM; Inigo Zaera C; Servicio de Neumologia, Hospital Doctor Peset, Valencia.; To analyze the situations that make chemoprophylaxis for tuberculosis difficult. One hundred twenty-eight patients consecutive (106 HIV negative and 22 HIV positive) diagnosed of tuberculosis (TB) were studied. The patients were interviewed and a questionnaire was filled out in order to identify risk groups and determ
5H-pyrrolo[1,2-b] [1,2,5]benzothiadiazepines (PBTDs): a novel class of non-nucleoside reverse transcriptase inhibitors.: Bioorg Med Chem. 1996 Jun;4(6):837-50. Unique Identifier : AIDSLINE MED/96415266; Artico M; Silvestri R; Pagnozzi E; Stefancich G; Massa S; Loi AG; Putzolu M; Corrias S; Spiga MG; La Colla P; Dipartimento di Studi Farmaceutici, Universita di Roma La Sapienza,; Italy.; With the aim of developing novel inhibitors of human immunodeficiency virus, various derivatives (10-17) related to 5H-pyrrolo[1,2-b] [1,2,5]benzothiadiazepine (PBTD) were prepared and tested in vitro. The title tricyclic derivatives were obtained by intramolecular cyclization of the open-chain intermediate arylpyrryl
Viral immunity: interferons jog old T-cell memories.: Curr Biol. 1996 Oct 1;6(10):1254-5. Unique Identifier : AIDSLINE MED/97147779; Gray D; Department of Immunology, Royal Postgraduate Medical School,; Hammersmith Hospital, London, UK.; The mechanism by which life-long immunity to viruses persists is a matter of some controversy. Interferons induced by subsequent unrelated viral infections may propagate existing memory T cells non-specifically.
Gamma delta T cell help of B cells is induced by repeated parasitic infection, in the absence of other T cells.: Curr Biol. 1996 Oct 1;6(10):1317-25. Unique Identifier : AIDSLINE MED/97147787; Pao W; Wen L; Smith AL; Gulbranson-Judge A; Zheng B; Kelsoe G; MacLennan IC; Owen MJ; Hayday AC; Department of Biology, Yale University, New Haven, Connecticut 06520,; USA.; BACKGROUND: gamma delta T cells, like alpha beta T cells, are components of all well-studied vertebrate immune systems. Yet, the contribution of gamma delta T cells to immune responses is poorly characterized. In particular, it has not been resolved whether gamma delta cells, independent of any other T cells, can help
Functional analysis of Fas signaling in vivo using synthetic inducers of dimerization.: Curr Biol. 1996 Jul 1;6(7):839-47. Unique Identifier : AIDSLINE MED/96432827; Spencer DM; Belshaw PJ; Chen L; Ho SN; Randazzo F; Crabtree GR; Schreiber SL; Howard Hughes Medical Institute, Department of Developmental Biology,; Stanford University Medical School, California 94305, USA.; dspencer@bcm.tmc.edu; BACKGROUND: Genetic abnormalities in the Fas receptor or its trimeric ligand, FasL, result in massive T-cell proliferation and a lupus-like autoimmune syndrome, which was initially attributed to excessive lymphoproliferation but is now ascribed to the absence of Fas-mediated cell death. Although Fas is normally expres
HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs.: Curr Biol. 1996 Jul 1;6(7):848-54. Unique Identifier : AIDSLINE MED/96432828; Fritz CC; Green MR; Howard Hughes Medical Institute, Program in Molecular Medicine,; University of Massachusetts Medical Center, Worcester 01605, USA.; BACKGROUND: The structural proteins of human immunodeficiency virus type 1 (HIV-1) are encoded by intron-containing mRNAs that normally are retained in the nucleus. A viral regulatory protein, Rev, specifically induces the accumulation of these transcripts in the cytoplasm. Rev is an RNA-binding protein that also cont
CONRAD: a method for identification of variable and conserved regions within proteins by scale-space filtering.: Comput Appl Biosci. 1996 Jun;12(3):197-203. Unique Identifier : AIDSLINE MED/97026209; Herrmann G; Schon A; Brack-Werner R; Werner T; Institut fur Medizinische Informatik und Systemforschung,; GSF-Forschungszentrum fur Umwelt und Gesundheit GmbH,; Oberschleissheim, Germany.; Advanced sequencing techniques allow rapid deduction of individual amino acid sequences of highly related proteins. Due to their quasi-species nature, viral genomes (e.g. HIV-1) represent one of the most common sources of related proteins. Another example of related proteins are immunoglobulins. Local differences in a
Three new studies expand understanding of MAC therapy [news]: Am J Health Syst Pharm. 1996 Oct 15;53(20):2376, 2380. Unique Identifier : AIDSLINE MED/97054833
In vivo induction of interleukin-1 bioactivity in brain tissue after intracerebral infusion of native gp 120 and gp 160.: Neuroimmunomodulation. 1996 Jan-Feb;3(1):56-61. Unique Identifier : AIDSLINE MED/97047441; Quan N; Zhang Z; Emery M; Lai E; Bonsall R; Kalyanaraman VS; Weiss JM; Department of Psychiatry and Behavioral Sciences, Emory University; School of Medicine, Atlanta, Ga, USA.; We have previously reported that intracerebral infusion of recombinant human immunodeficiency virus envelope protein gp 120 induced interleukin-1 (IL-1) bioactivity in rat brain. In this study, we tested the ability of native gp 120 and gp 160 to induce IL-1 activity in rat brain and also examined whether altering the
Induction of antigen-specific tumor immunity by genetic and cellular vaccines against MAGE: enhanced tumor protection by coexpression of granulocyte-macrophage colony-stimulating factor and B7-1.: Mol Med. 1996 Sep;2(5):545-55. Unique Identifier : AIDSLINE MED/97053992; Bueler H; Mulligan RC; Howard Hughes Medical Institute, Children's Hospital, Boston,; Massachusetts, USA.; BACKGROUND: A number of tumors express antigens that are recognized by specific cytotoxic T cells. The normal host immune responses, however, are not usually sufficient to cause tumor rejection. Using appropriate immunization strategies, tumor-specific antigens may serve as targets against which tumor-destructive immu
Mycobacterium haemophilum: microbiology and expanding clinical and geographic spectra of disease in humans.: Clin Microbiol Rev. 1996 Oct;9(4):435-47. Unique Identifier : AIDSLINE MED/97049617; Saubolle MA; Kiehn TE; White MH; Rudinsky MF; Armstrong D; Department of Pathology, Good Samaritan Regional Medical Center,; Phoenix, Arizona 85006, USA.; Reports of the association of Mycobacterium haemophilum with disease in humans have greatly increased. At least 64 cases have now been reported, with symptoms ranging from focal lesions to widespread, systemic disease. The organism is now known to cause primarily cutaneous and subcutaneous infection, septic arthritis,
Pediatric human immunodeficiency virus infection.: Clin Microbiol Rev. 1996 Oct;9(4):448-68. Unique Identifier : AIDSLINE MED/97049618; Domachowske JB; Pediatric Infectious Disease, State University of New York Health; Science Center, Syracuse 13210, USA. jdomach@helix.nih.gov; In the past decade, an increase in pediatric human immunodeficiency virus (HIV) infection has had a substantial impact on childhood morbidity and mortality worldwide. The vertical transmission of HIV from mother to infant accounts for the vast majority of these cases. Identification of HIV-infected pregnant women need
Human endogenous retroviruses [letter; comment]: Clin Microbiol Rev. 1996 Oct;9(4):585. Unique Identifier : AIDSLINE MED/97049625; Michalski F
Age and religion selection biases in HIV-1 prevalence data from antenatal clinics in Manicaland, Zimbabwe.: Cent Afr J Med. 1995 Nov;41(11):339-46. Unique Identifier : AIDSLINE MED/97086382; Gregson S; Zhuwau T; Anderson RM; Chimbadzwa T; Chiwandiwa SK; Blair Research Institute, Harare, Zimbabwe.; Sera from 487 women attending antenatal clinics in two areas of Manicaland were tested for the presence of HIV-1 infection. In the Honde Valley and Rusitu Valley areas, 24,3 pc and 14 pc respectively, were found to be infected. HIV-1 infection was found to be associated with age, marital status and location. Younger w
A case of gram negative pericarditis in a patient with the Acquired Immunodeficiency Syndrome.: Cent Afr J Med. 1995 Nov;41(11):355-7. Unique Identifier : AIDSLINE MED/97086384; Manyemba JE; Ternmouth I; Allain TJ; Department of Medicine, University of Zimbabwe, Harare.; A diagnosis of pericarditis due to Escherichia coli was made in a 38 year old male patient with AIDS. The source of infection in this patient was not established. This case highlights the need to carry out a diagnostic pericardiocentesis in immunocompromised patients presenting with pericardial effusions and the impor
Serostatus surveillance testing of HIV-I infection among Zimbabwean psychiatric inpatients, in Zimbabwe.: Cent Afr J Med. 1996 Sep;42(9):254-7. Unique Identifier : AIDSLINE MED/97151868; Acuda SW; Sebit MB; Department of Psychiatry, University of Zimbabwe, Harare, Zimbabwe.; OBJECTIVE: To investigate seroprevalence rates of HIV infection among Zimbabwean psychiatric inpatients. DESIGN: An identity-unlinked procedure, for ELISA and Western blot HIV testing of consecutively admitted psychiatric patients, was used during the four month period of the study. The seropositive groups were furthe
Thrombocytopenia in human immune deficiency virus infection. Literature review, case report and future directions.: Cent Afr J Med. 1996 Sep;42(9):271-2. Unique Identifier : AIDSLINE MED/97151873; Abayomi EA; Coutts AM; Department of Haematology, University of Zimbabwe Medical School,; Harare, Zimbabwe. doc@leopard.uz.zw
Phorbol ester effects on splenic lymphocyte composition and cytotoxic T cell activities of SSIN mice: a strain deficient in CD8+ T cells.: Carcinogenesis. 1996 Dec;17(12):2617-24. Unique Identifier : AIDSLINE MED/97158737; Yoon HL; Singh KP; Ratner S; Reiners JJ Jr; Institute of Chemical Toxicology, Wayne State University, Detroit, MI; 48201, USA.; SSIN mice are considerably more sensitive to the effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) in two-stage skin carcinogenesis protocols than are most other strains and stocks of mice. Experiments were performed to determine whether there was an immunological basis for this sensitivity. SSIN mice were haploty
HLA-DR polymorphism modulates the cytokine profile of Mycobacterium leprae HSP-reactive CD4+ T cells.: Clin Immunol Immunopathol. 1997 Jan;82(1):60-7. Unique Identifier : AIDSLINE MED/97152460; Mitra DK; Rajalingam R; Taneja V; Bhattacharyya BC; Mehra NK; Histocompatibility and Immunogenetics Department, All India Institute; of Medical Sciences, New Delhi.; In the present study, in vitro attempts have been made to define the cytokine profile of CD4+ T cells from polar leprosy patients and healthy individuals against Mycobacterium leprae-derived heat shock proteins (HSPs), HSP65 and HSP18, and their trypsin-digested fragments, relating to HLA-DR polymorphism. While all tr
Clinical improvement in chronic fatigue syndrome is not associated with lymphocyte subsets of function or activation.: Clin Immunol Immunopathol. 1997 Jan;82(1):83-91. Unique Identifier : AIDSLINE MED/97152463; Peakman M; Deale A; Field R; Mahalingam M; Wessely S; Department of Immunology, King's College School of Medicine &; Dentistry, London, United Kingdom.; The relationship between markers of immune function and chronic fatigue syndrome (CFS) is controversial. To examine the relationship directly, 43 subjects with CFS entering a randomized controlled trial of a nonpharmacological treatment for CFS gave samples for immunological analysis before and after treatment. Percen
Childhood cancers in a referral hospital in Kenya: a review.: East Afr Med J. 1996 Oct;73(10):647-50. Unique Identifier : AIDSLINE MED/97151895; Macharia WM; Department of Paediatrics, Unversity of Nairobi, Kenya.; Following the outbreak of human immune deficiency virus (HIV) infection in the early 1980 s, there has been an increase in reported cases of Kaposi s sarcoma, among other childhood malignancies, from the East and Central African region. To assess the status of childhood cancers at Kenyatta National Hospital during the
Attitudes to prenatal testing and notification for HIV infection in Nairobi, Kenya.: East Afr Med J. 1996 Oct;73(10):665-9. Unique Identifier : AIDSLINE MED/97151898; Marjan RS; Ruminjo JK; Fatuma El Seyyid Maternity Hospital, Mombasa.; Four hundred antenatal clinic attendants were surveyed for their attitude to testing and notification for HIV infection test results. The participants were systematically sampled from the antenatal clinic at the Kenyatta National Hospital, Nairobi, and interviewed using a closed-ended structured questionnaire. All the
Immunohaematological findings in healthy and HIV-1 infected adults in Dar es Salaam, Tanzania.: East Afr Med J. 1996 Oct;73(10):670-4. Unique Identifier : AIDSLINE MED/97151899; Urassa WK; Lyamuya EF; Mbena E; Kagoma C; Bredberg Raden U; Pallangyo KP; Magessa P; Mhalu FS; Biberfeld G; Department of Microbiology and Immunology, Muhimbili University; College, Dar es Salaam, Tanzania.; In order to assess the prognostic value of lymphocyte subsets and immune activation markers in HIV-1 infected Tanzanian patients, peripheral white blood cell(WBC) count, total lymphocytes, CD4+ and CD8+ T-lymphocytes and Beta-2 microglobulin (B-2M) concentrations were determined among healthy HIV-1 seronegative Tanzan
High frequency of sexually transmitted diseases among pregnant women in Dar es Salaam, Tanzania: need for intervention.: East Afr Med J. 1996 Oct;73(10):675-8. Unique Identifier : AIDSLINE MED/97151900; Mwakagile D; Swai AB; Sandstrom E; Urassa E; Biberfeld G; Mhalu FS; Department of Microbiology/Immunology, Muhimbili University College of; Health Sciences, Dar es Salaam, Tanzania.; In order to determine the prevalence and characteristics of sexually transmitted diseases (STDs) in pregnant women (PW) attending a primary health care antenatal clinic (ANC) in metropolitan Dar es Salaam, Tanzania , a randomly selected sample of PW in their second or third trimes
Endocrine and metabolic disturbances in human immunodeficiency virus infection and the acquired immune deficiency syndrome.: Endocr Rev. 1996 Oct;17(5):518-32. Unique Identifier : AIDSLINE MED/97052389; Sellmeyer DE; Grunfeld C; Department of Medicine, University of California, San Francisco, USA.; Numerous alterations in endocrine function are observed in HIV infection. Direct destruction of endocrine organs by HIV itself or by invasive infection with opportunistic organisms resulting in loss of function is rare. When acutely ill, HIV patients can develop the metabolic derangements that accompany any severe sys
Binding and kinetic properties of HIV-1 reverse transcriptase markedly differ during initiation and elongation of reverse transcription.: EMBO J. 1996 Dec 16;15(24):7178-87. Unique Identifier : AIDSLINE MED/97157508; Lanchy JM; Ehresmann C; Le Grice SF; Ehresmann B; Marquet R; Unite Propre de Recherche No. 9002 du Centre National de la Recherche; Scientifique, Institut de Biologie Moleculaire et Cellulaire,; Strasbourg, France.; We recently showed that primer tRNA3Lys, human immunodeficiency virus type 1 (HIV-1) RNA and HIV-1 reverse transcriptase (RT) form a specific complex of initiation of reverse transcription that can be functionally distinguished from the elongation complex, which can be obtained by substituting an 18mer oligodeoxyribon
HIV-1 viraemia changes in patients with and without syncytium-inducing phenotype treated with nucleoside analogues: a case-control study.: Eur J Clin Invest. 1996 Oct;26(10):923-8. Unique Identifier : AIDSLINE MED/97068607; Leal M; Torres Y; Medrano FJ; Rey C; Caruz A; Sanchez-Quijano A; Lissen E; Department of Internal Medicine, Virgen del Rocio University Hospital,; Seville, Spain.; The objective of the present study was to investigate the effect of the nucleoside analogue treatment on serum viraemia, CD4+ cell count and disease progression in patients with and without syncytium-inducing (SI) HIV-1 variants. To achieve this in a case-control study, 11 nucleoside-naive patients harbouring SI varia
Oxidant-antioxidant imbalance in the experimental interstitial lung disease induced in sheep by visna-maedi virus.: Eur Respir J. 1996 Oct;9(10):1983-8. Unique Identifier : AIDSLINE MED/97058125; Cottin V; Court-Fortune I; Crevon J; Mornex JF; Laboratoire d'Immunologie et de Biologie Pulmonaire, INSERM CJF 93-08,; Lyon, France.; Infection of sheep by visna-maedi virus causes an interstitial pneumonitis similar to that associated with human immunodeficiency virus type-1 (HIV-1). Visna-maedi virus infection of alveolar macrophages leads to their activation. In this study we determined whether an imbalance in oxidant-antioxidant activity may be
Resistance to fluconazole and cross-resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol delta5,6-desaturation.: FEBS Lett. 1997 Jan 2;400(1):80-2. Unique Identifier : AIDSLINE MED/97153227; Kelly SL; Lamb DC; Kelly DE; Manning NJ; Loeffler J; Hebart H; Schumacher U; Einsele H; Krebs Institute for Biomolecular Research, Department of Molecular; Biology and Biotechnology, Sheffield University, UK.; S.Kelly@Sheffield.ac.uk; Fluconazole resistance occurs in > 10% of cases of candidosis during the late stages of AIDS. We show here in two clinical isolates that resistance was caused by defective sterol delta5,6-desaturation. This altered the type of sterol accumulating under fluconazole treatment from 14alpha-methylergosta-8,24(28)-dien-3be
Cervical intraepithelial neoplasia in pregnant intravenous drug users infected with human immunodeficiency virus type 1.: Eur J Obstet Gynecol Reprod Biol. 1996 Sep;68(1-2):175-8. Unique Identifier : AIDSLINE MED/97041432; Spinillo A; Tenti P; Baltaro F; Piazzi G; Iasci A; De Santolo A; Department of Obstetrics and Gynecology, University of Pavia, IRCCS; Policlinico S. Matteo, Italy.; OBJECTIVE: The purpose of this study was to evaluate the frequency and natural history of cervical intraepithelial neoplasia (CIN) during pregnancy in past or current intravenous drug users infected with human immunodeficiency virus type 1 HIV-1). STUDY DESIGN: We prospectively evaluated 48 pregnant HIV-1 seropositive
Low incidence of congenital toxoplasmosis in children born to women infected with human immunodeficiency virus. European Collaborative Study and Research Network on Congenital Toxoplasmosis.: Eur J Obstet Gynecol Reprod Biol. 1996 Sep;68(1-2):93-6. Unique Identifier : AIDSLINE MED/97041417; In children born to immunocompetent women, congenital toxoplasmosis almost always results from primary infection during pregnancy. However, reactivation of latent toxoplasmosis during pregnancy could occur in HIV-infected pregnant women, particularly in those who are severely immunocompromised, and result in maternal-
Primary reproductive health care in Tanzania [see comments]: Eur J Obstet Gynecol Reprod Biol. 1996 Oct;69(1):41-5. Unique Identifier : AIDSLINE MED/97066474; Walraven GE; Sumve Designated District Hospital, Mantare via Mwanza, Tanzania.; The introduction of community based reproductive health care programmes in Tanzania integrated within primary health care PHC) programmes is discussed. These programmes should address safe motherhood, fertility awareness and sexually transmitted diseases (STDs), including AIDS. I
Potential of chimaeric plant virus particles as novel, stable vaccines.: Dev Biol Stand. 1996;87:201-5. Unique Identifier : AIDSLINE MED/97006725; Xu F; Jones TD; Rodgers PB; Axis Genetics Ltd, Babraham, Cambridge, UK.; Technology has been developed for the expression of multiple copies of epitopes from human and animal pathogens on the surface of assembled particles of a plant virus (cowpea mosaic virus). The technology, termed the Chimaeric Virus Particle (CVP) Technology, can be exploited for the production of vaccines in plants.
Systemic bias of cytokine production toward cell-mediated immune regulation in IDDM and toward humoral immunity in Graves' disease.: Diabetes. 1997 Feb;46(2):237-43. Unique Identifier : AIDSLINE MED/97153410; Kallmann BA; Huther M; Tubes M; Feldkamp J; Bertrams J; Gries FA; Lampeter EF; Kolb H; Clinical Department of the Diabetes Research Institute,; Heinrich-Heine-University of Dusseldorf, Germany.; Disturbed immune regulation has been postulated to be crucial in the pathogenesis of IDDM and other autoimmune or allergic diseases. We therefore tested the hypothesis of a general bias in the peripheral immune system in patients with recent-onset IDDM or Graves disease in comparison to healthy control subjects by st
HIV/AIDS related knowledge, attitudes, and preventive behavior of pregnant Korean women.: Image J Nurs Sch. 1996 Winter;28(4):321-4. Unique Identifier : AIDSLINE MED/97140873; Chang SB; Hill MN; College of Nursing, Yonsei University, Seoul, Korea.; OBJECTIVE: To assess HIV-AIDS-related knowledge, attitudes, and preventive behavior of pregnant Korean women before designing patient and public education programs. DESIGN: Pre-experimental cross-sectional survey. POPULATION, SAMPLE, SETTING, YEARS: Convenience sample of 409 women at six prenatal clinics in Seoul, Kor
Effect of calcitonin gene-related peptide and vasoactive intestinal peptide on murine CD4 and CD8 T cell proliferation.: Immunol Lett. 1996 Apr;50(1-2):105-13. Unique Identifier : AIDSLINE MED/96385737; Teresi S; Boudard F; Bastide M; Immunology and Parasitology Laboratory, University of Montpellier I,; Faculty of Pharmacy, France.; The effects of alpha calcitonin gene-related peptide (alpha CGRP) and vasoactive intestinal peptide (VIP) on the proliferation of CD4 and CD8 T-murine lymphocytes were investigated. When stimulated by a combination of phorbol 12-myristate-13-acetate PMA) and calcium ionophore (A23187), both neuropeptides in a range of
TPSg, an anti-human immunodeficiency virus (HIV-1) agent, isolated from the Cupressaceae Thuja occidentale L. (Arborvitae) enhances in vivo hemopoietic progenitor cells recovery in sublethally irradiated mice.: Immunol Lett. 1996 Apr;50(1-2):119-22. Unique Identifier : AIDSLINE MED/96385739; Hassan HT; Drize NJ; Sadovinkova EYu; Gan OI; Gohla S; Schrum S; Neth RD; Bone Marrow Transplantation Center, Humburg University Hospital; Eppendorf, Germany.
The expression of CD8 on B lymphocytes in HIV-infected individuals.: Immunol Lett. 1996 Apr;50(1-2):23-7. Unique Identifier : AIDSLINE MED/96385725; Schlesinger M; Rabinowitz R; Levy P; Maayan S; Hubert H. Humphrey Center for Experimental Medicine and Cancer; Research, Hebrew University, Hadassah Medical School, Jerusalem,; Israel.; In HIV-1 infected individuals the CD8 + T lymphocyte population is markedly activated as reflected by increased expression of the CD38 and CD45RO activation markers and elevated serum levels of soluble CD8 antigen. We have previously shown that in vitro activation of peripheral blood lymphocytes results in the appeara
Different trypanozoan species possess CD8 dependent lymphocyte triggering factor-like activity.: Immunol Lett. 1996 Apr;50(1-2):71-80. Unique Identifier : AIDSLINE MED/96385732; Bakhiet M; Buscher P; Harris RA; Kristensson K; Wigzell H; Olsson T; Department of Medicine, Karolinska Hospital, Stockholm, Sweden.; moba@molmed.ks.se; Trypanosoma brucei brucei (T. b. brucei) release a molecule, trypanosome derived lymphocyte triggering factor (TLTF), which stimulates CD8+ cells to produce cytokines and to proliferate. We now report that T. evansi, T.b. gambiense and T.b. rhodesiense also contain factor(s) with similar activity. Thus, homogenates fr
Proceedings of the 1st International summit meeting on Immunological Correlates of Protection from HIV Infection and Disease. Mont Pelerin, Switzerland, 27-30 May 1995.: Immunol Lett. 1996 Jun;51(1-2):1-135. Unique Identifier : AIDSLINE MED/97165774
Immunogenicity of full length and truncated forms of the human immunodeficiency virus type I envelope glycoprotein.: Immunol Lett. 1996 Jun;51(1-2):101-5. Unique Identifier : AIDSLINE MED/96407299; McKeating JA; Shotton C; Jeffs S; Palmer C; Hammond A; Lewis J; Oliver K; May J; Balfe P; University of Reading, School of Animal and Microbial Sciences,; Whiteknights, UK.; We have monitored the immunogenicity of a V1V2 sub-fragment of gp 120 in contrast to the full length protein and to a truncated form (PR12) where the V1, V2 and V3 regions were removed. In contrast to previously published work [1] these studies show that monomeric forms of envelope are capable of inducing antibodies s
Passive immune globulin therapy in the SIV/macaque model: early intervention can alter disease profile.: Immunol Lett. 1996 Jun;51(1-2):107-14. Unique Identifier : AIDSLINE MED/96407300; Haigwood NL; Watson A; Sutton WF; McClure J; Lewis A; Ranchalis J; Travis B; Voss G; Letvin NL; Hu SL; Hirsch VM; Johnson PR; Department of Immunodeficiency and Immunosuppression, Bristol-Myers; Squibb Pharmaceutical Research Institute, Seattle, Washington 98121,; USA. Nancy L. Haigwood@ccmail.bms.com; One of the major questions in AIDS is the role that the host immune system and the virus play in the dynamics of infection and the development of AIDS in an infected individual. In order to test the role of antibody in controlling viral infection, high-dose SIV-immune globulin was passively transferred to infected mac
Recombinant subunit vaccines as an approach to study correlates of protection against primate lentivirus infection.: Immunol Lett. 1996 Jun;51(1-2):115-9. Unique Identifier : AIDSLINE MED/96407301; Hu SL; Polacino P; Stallard V; Klaniecki J; Pennathur S; Travis BM; Misher L; Kornas H; Langlois AJ; Morton WR; Benveniste RE; Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA; 98121, USA.; Using pathogenic simian immunodeficiency virus (SIV) infection of macaques as a model, we explored the limits of the protective immunity elicited by recombinant subunit vaccines and examined factors that affect their efficacy. Envelope gp 160 vaccines, when used in a live recombinant virus-priming and subunit-protein-
Correlates of protective immunity against HIV-1 infection in immunized chimpanzees.: Immunol Lett. 1996 Jun;51(1-2):121-4. Unique Identifier : AIDSLINE MED/96407302; Murthy KK; Cobb EK; Rouse SR; Lunceford SM; Johnson DE; Galvan AR; Department of Virology and Immunology, Southwest Foundation for; Biomedical Research, San Antonio, TX 78228-0147, USA.; Several experimental vaccination strategies have been developed to prevent primary infection with human immunodeficiency virus HIV), and as immunotherapeutics for infected individuals. Many of the putative vaccines have been tested in chimpanzees (p. troglodytes) to determine their safety, efficacy, and to delineate i
Cytotoxic T cells--protection from disease progression--protection from infection.: Immunol Lett. 1996 Jun;51(1-2):125-8. Unique Identifier : AIDSLINE MED/96407303; Gotch F; Gallimore A; McMichael A; Department of Immunology, Chelsea and Westminster Hospital, London,; UK.; We briefly review current evidence which indicates that major histocompatibility complex (MHC)-restricted, virus-specific cytotoxic T cells may be of immunological importance in protection from infection with immunodeficiency virus or with protection from disease progression which would finally result in acquired immu
Attenuated SIV imparts immunity to challenge with pathogenic spleen-derived SIV but cannot prevent repair of the nef deletion.: Immunol Lett. 1996 Jun;51(1-2):129-35. Unique Identifier : AIDSLINE MED/96407304; Stahl-Hennig C; Dittmer U; Nisslein T; Pekrun K; Petry H; Jurkiewicz E; Fuchs D; Wachter H; Rud EW; Hunsmann G; Department of Virology and Immunology, German Primate Centre,; Gottingen, Germany.; To date, some success has been achieved with several experimental vaccines against AIDS in the available animal models. In the simian immunodeficiency virus (SIV) macaque model protection against superinfection was obtained by preinfection with a virus attenuated by a deletion in nef. To investigate the efficacy of SI
Fluctuations in steady state level of genomic HIV-1 RNA and replication intermediates related to disease progression rate.: Immunol Lett. 1996 Jun;51(1-2):15-22. Unique Identifier : AIDSLINE MED/96407286; Jurriaans S; Goudsmit J; Human Retrovirus Laboratory, University of Amsterdam, The Netherlands.; Steady state levels of HIV-1 genomic RNA and unintegrated circular DNA fluctuate in the course of HIV-1 infection. Genomic RNA in serum was detected using the NASBA technique and the amount of circular DNA was assessed by PCR. Quantification was done by competitive techniques using co-amplification of internal standar
Interplay of HIV-1 phenotype and neutralizing antibody response in pathogenesis of AIDS.: Immunol Lett. 1996 Jun;51(1-2):23-8. Unique Identifier : AIDSLINE MED/96407287; Scarlatti G; Leitner T; Hodara V; Jansson M; Karlsson A; Wahlberg J; Rossi P; Uhlen M; Fenyo EM; Albert J; Department of Virology, Karolinska Institute, Stockholm, Sweden.; A majority of human immunodeficiency virus type 1 (HIV-1) infected individuals display a rapid loss of CD4+ lymphocytes with fast progression towards overt acquired immunodeficiency syndrome (AIDS). However, a small proportion of individuals infected by HIV-1 remain immunologically intact for many years. In order to i
Persistently seronegative men from whom HIV-1 has been isolated are genetically and immunologically distinct.: Immunol Lett. 1996 Jun;51(1-2):29-33. Unique Identifier : AIDSLINE MED/96407288; Detels R; Mann D; Carrington M; Hennessey K; Wu Z; Hirji KF; Wiley D; Visscher BR; Giorgi JV; Los Angeles Center of the Multicenter AIDS Cohort Study, Department of; Epidemiology, UCLA School of Public Health, USA.; Studies in both monkeys and humans have suggested that transient infection with HIV-1 can occur without provoking a measurable humoral immune response. The objective of this study was to look for genetic and immunologic correlates of transient HIV-1 infection in antibody-negative men from whom HIV-1 had been isolated.
Predominance of defective proviral sequences in an HIV + long-term non-progressor.: Immunol Lett. 1996 Jun;51(1-2):3-6. Unique Identifier : AIDSLINE MED/96407284; Schwartz DH; Viscidi R; Laeyendecker O; Song H; Ray SC; Michael N; Department of Molecular Microbiology and Immunology, Johns Hopkins; School of Hygiene and Public Health, Baltimore, MD 21205, USA.; We examined the accessory genes and envelope V3 region of provirus obtained over a 5 year period from an HIV+ long-term non-progressor with very low viral load and no in vitro recoverable virus during that same time span. LTR sequences supported normal Tat-mediated promoter activity. Multiple clones of nef sequences w
The role of major histocompatibility complex polymorphisms on SIV infection in rhesus macaques.: Immunol Lett. 1996 Jun;51(1-2):35-8. Unique Identifier : AIDSLINE MED/96407289; Bontrop RE; Otting N; Niphuis H; Noort R; Teeuwsen V; Heeney JL; Biomedical Primate Research Centre, Rijswijk, The Netherlands.; To investigate whether Major Histocompatibility Complex (MHC) polymorphisms influence either susceptibility to SIV infection or progress to actual disease, rhesus monkeys were subjected to various forms of SIV infection and screened for allelic MHC heterogeneity by means of serological and biochemical methods. Animals
HIV-1-specific immunity in persistently seronegative individuals at high risk for HIV infection.: Immunol Lett. 1996 Jun;51(1-2):39-43. Unique Identifier : AIDSLINE MED/96407290; Beretta A; Furci L; Burastero S; Cosma A; Dinelli ME; Lopalco L; DeSantis C; Tambussi G; Carrow E; Sabbatani S; Clerici M; Lazzarin A; Siccardi AG; DIBIT and Infectious Diseases Clinic, S. Raffaele Scientific; Institute, Milano, Italy.; A growing number of reports indicates that certain groups of individuals who almost certainly have been exposed to human immunodeficiency virus (HIV), yet continue to exhibit no signs or symptoms of infection, often have subtle evidence of specific immunity. We studied such a high-risk (HR) cohort of persistently sero
Immune strategies utilized by lentivirus infected chimpanzees to resist progression to AIDS.: Immunol Lett. 1996 Jun;51(1-2):45-52. Unique Identifier : AIDSLINE MED/96407291; Heeney J; Bogers W; Buijs L; Dubbes R; ten Haaft P; Koornstra W; Niphuis H; Nara P; Teeuwsen V; Department of Virology, Biomedical Primate Research Centre, Rijswijk,; The Netherlands. heeney@bprc.nl; HIV-1 infected chimpanzees are relatively resistant to the development of AIDS despite their close genetic relatedness to humans and their susceptibility to HIV-1 infection. We have systematically studied possible reasons for their relative ability to maintain T helper (Th) cell numbers and immune competence in the pr
SIVagm infection of its natural African green monkey host.: Immunol Lett. 1996 Jun;51(1-2):53-8. Unique Identifier : AIDSLINE MED/96407292; Norley SG; Paul-Ehrlich-Institut, Langen, Germany.; Possible reasons for the apathogenicity of simian immunodeficiency virus (SIVagm) in its natural African green monkey (AGM) host were investigated. In most respects, the SIVagm/AGM system was shown to resemble human immunodeficiency virus type 1 (HIV-1) infection of humans. AGMs were shown to respond to infection with
Immunological and virological studies of natural SIV infection of disease-resistant nonhuman primates.: Immunol Lett. 1996 Jun;51(1-2):59-68. Unique Identifier : AIDSLINE MED/96407293; Villinger F; Folks TM; Lauro S; Powell JD; Sundstrom JB; Mayne A; Ansari AA; Department of Pathology and Laboratory Medicine, Emory University; School of Medicine, Atlanta, GA 30322, USA.; Nonhuman primates naturally infected with simian immunodeficiency virus (SIV), while maintaining chronic viremia, do not develop any disease associated with lentiviral infection. Thus they provide a unique model to define the mechanism(s) by which they remain infected but disease-resistant. The purpose of this article
Correlates of protection in HIV infection and the progression of HIV infection to AIDS.: Immunol Lett. 1996 Jun;51(1-2):69-73. Unique Identifier : AIDSLINE MED/96407294; Clerici M; Shearer GM; Cattedra di Immunologia, Universita degli Studi di Milano, Italy.; mago@imiucca.csi.unimi.it; Exposure to human immunodeficency virus (HIV) can result in HIV infection which is defined by seroconversion and the detection of HIV-specific antibodies. Nevertheless, in every cohort at risk for HIV infection, individuals are present in whom seroconversion is not observed despite multiple documented exposures to HIV
Characterization of long-term survivors of human immunodeficiency virus type 1 infection.: Immunol Lett. 1996 Jun;51(1-2):7-13. Unique Identifier : AIDSLINE MED/96407285; Cao Y; Qin L; Zhang L; Safrit J; Ho DD; Aaron Diamond AIDS Research Center, New York University School of; Medicine, NY 10016, USA.; A small population of HIV-1-infected individuals remains clinically healthy and immunologically normal for more than ten years. We have studied ten subjects who have been asymptomatic with normal and stable CD4+ lymphocyte counts, despite 12 to 16 years of HIV-1 infection, to gain information on the determinants of no
Comparative analysis of apoptosis in HIV-infected humans and chimpanzees: relation with lymphocyte activation.: Immunol Lett. 1996 Jun;51(1-2):75-81. Unique Identifier : AIDSLINE MED/96407295; Gougeon ML; Lecoeur H; Heeney J; Boudet F; Departement SIDA et Retrovirus, Institut Pasteur, Paris, France.; mlgougeo@pasteur.fr; Programmed-cell death (apoptosis) is a physiological cell death process which appears exacerbated in peripheral lymphocytes from HIV-infected persons. On the contrary, a barely detectable level of apoptosis is found in peripheral lymphocytes from HIV-infected chimpanzees, which support long-term productive infection w
Role for CD30 in HIV expression.: Immunol Lett. 1996 Jun;51(1-2):83-8. Unique Identifier : AIDSLINE MED/96407296; Romagnani S; Annunziato F; Manetti R; Almerigogna F; Biagiotti R; Giudizi MG; Ravina A; Gianno V; Tomasevic L; Maggi E; Institute of Internal Medicine and Immunoallergology, University of; Florence, Italy.; CD30 is a member of the tumor necrosis factor (TNF)-receptor superfamily, whose ligand (CD30L) has been identified on B cells, activated macrophages and a subset of activated T cells. We show here that infection in vitro with human immunodeficiency virus HIV) of CD4+ T-cell clones generated from HIV-seronegative indiv
Mechanisms contributing to the neutralization of HIV-1.: Immunol Lett. 1996 Jun;51(1-2):89-93. Unique Identifier : AIDSLINE MED/96407297; Zolla-Pazner S; Veterans Affairs Medical Center, New York, NY 10010, USA.; The phenomenon of virus neutralization is a function of three variables: the antibody (Ab), the virus and the target cell. Variation in any one of these parameters may drastically affect the results of assays for neutralization. In focusing on the virus as a variable in assays for the neutralization of HIV-1, it has b
Broad cross-neutralizing activity in serum is associated with slow progression and low risk of transmission in primate lentivirus infections.: Immunol Lett. 1996 Jun;51(1-2):95-9. Unique Identifier : AIDSLINE MED/96407298; Fenyo EM; Putkonen P; Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm,; Sweden.; Sera from human immunodeficiency virus type 1 and type 2 (HIV-1 and HIV-2)-infected humans were tested with autologous (from the same individual) and heterologous (from other individuals) virus isolates in a neutralization assay. Similarly, sera from experimentally simian immunodeficiency virus (SIVsm from sooty manga
Incidence of HIV-1 infection in adults and socio-demographic characteristics of seroconverters in a rural population in Uganda: 1990-1994.: Int J Epidemiol. 1996 Oct;25(5):1077-82. Unique Identifier : AIDSLINE MED/97079786; Kengeya-Kayondo JF; Kamali A; Nunn AJ; Ruberantwari A; Wagner HU; Mulder DW; Programme on AIDS in Uganda, Uganda Virus Research Institute, Entebbe,; Uganda.; BACKGROUND: To evaluate HIV-1 incidence among adults and socio-demographic risk factors in a rural population in Uganda , a prospective cohort study was carried out. METHODS: All consenting adult residents in a cluster of 15 neighbouring villages of the Masaka District of south-west
A case-control study of risk factors for seropositivity to human T-lymphotropic virus type I (HTLV-I) in Jamaica.: Int J Epidemiol. 1996 Oct;25(5):1083-9. Unique Identifier : AIDSLINE MED/97079787; Murphy EL; Wilks R; Hanchard B; Cranston B; Figueroa JP; Gibbs WN; Murphy J; Blattner WA; Department of Laboratory Medicine, University of California, San; Francisco 94143, USA.; BACKGROUND: We investigated behavioural and environmental risk factors for seropositivity to human T-lymphotropic virus type I HTLV-I). METHODS: A nested case-control study of 201 HTLV-I seropositive subjects and 225 age- and sex-matched seronegative controls was performed using questionnaire data from the enrollment
Health effects of human T-lymphotropic virus type I (HTLV-I) in a Jamaican cohort.: Int J Epidemiol. 1996 Oct;25(5):1090-7. Unique Identifier : AIDSLINE MED/97079788; Murphy EL; Wilks R; Morgan OS; Hanchard B; Cranston B; Figueroa JP; Gibbs WN; Murphy J; Blattner WA; Department of Laboratory Medicine, University of California, San; Francisco 94143, USA.; BACKGROUND: Other than adult T-cell leukaemia (ATL) and HTLV-I associated myelopathy (HAM), the health effects of infection with human T-lymphotropic virus type I (HTLV-I) are not well defined. METHOD: A cohort of 201 confirmed HTLV-I seropositive Jamaican food service workers and 225 seronegative controls of similar
Emotional distress in men with life-threatening illness.: Int J Nurs Stud. 1996 Oct;33(5):551-65. Unique Identifier : AIDSLINE MED/97041633; van Servellen G; Sarna L; Padilla G; Brecht ML; UCLA School of Nursing 90095-6917, USA.; This descriptive survey explored the relationship of health status, functional status, stressful life events, stress resistance resources and emotional distress in 60 men with life-threatening illness (N = 30 with cancer and N = 30 with AIDS). Sixty-two percent met CES-D criteria for clinical depression. This study s
Amphotericin B in a lipid emulsion for the treatment of cryptococcal meningitis in AIDS patients.: J Antimicrob Chemother. 1996 Jul;38(1):117-26. Unique Identifier : AIDSLINE MED/97011453; Joly V; Geoffray C; Reynes J; Goujard C; Mechali D; Maslo C; Raffi F; Yeni P; Hopital Bichat-Claude Bernard, Paris, France.; We determined the safety and efficacy of deoxycholate-amphotericin B (d-AmB) mixed with Intralipid (IL) as the initial treatment of AIDS-associated cryptococcal meningitis in a phase II, multicentre, non-comparative open study, assessing two dosages of ILd-AmB: 1 mg/kg (group A, n = 9) and 1.5 mg/kg group B, n = 6). P
In-vitro activity of antiviral agents used in AIDS against Salmonella typhi and non-typhoid salmonella [letter]: J Antimicrob Chemother. 1996 Jul;38(1):153-4. Unique Identifier : AIDSLINE MED/97011460; Sanchez-Carrillo C; Menasalvas A; Cotarelo M; Diaz MD; Cercenado E; Bouza E
Efficacy and tolerance of amphotericin B in a lipid emulsion in the treatment of visceral leishmaniasis in AIDS patients [letter]: J Antimicrob Chemother. 1996 Jul;38(1):154-7. Unique Identifier : AIDSLINE MED/97011461; Petit N; Parola P; Dhiver C; Gastaut JA
Endoprotease activities other than furin and PACE4 with a role in processing of HIV-I gp160 glycoproteins in CHO-K1 cells.: J Biol Chem. 1997 Jan 10;272(2):1344-8. Unique Identifier : AIDSLINE MED/97150906; Inocencio NM; Sucic JF; Moehring JM; Spence MJ; Moehring TJ; Department of Microbiology and Molecular Genetics, Markey Center for; Molecular Genetics, University of Vermont, Burlington 05405, USA.; We addressed the question of whether furin is the endoprotease primarily responsible for processing the human immunodeficiency virus type I (HIV-I) envelope protein gp160 in mammalian cells. The furin-deficient Chinese hamster ovary (CHO)-K1 strain RPE.40 processed gp160 as efficiently as wild-type CHO-K1 cells in viv
Constitutive dephosphorylation and activation of a member of the nuclear factor of activated T cells, NF-AT1, in Tax-expressing and type I human T-cell leukemia virus-infected human T cells.: J Biol Chem. 1997 Jan 17;272(3):1425-8. Unique Identifier : AIDSLINE MED/97153085; Good L; Maggirwar SB; Harhaj EW; Sun SC; Department of Microbiology and Immunology, Pennsylvania State; University College of Medicine, Hershey Medical Center, Hershey,; Pennsylvania 17033, USA.; The tax gene product of the type I human T-cell leukemia virus HTLV-I) transactivates interleukin-2 ( IL-2 ) gene through activation of an enhancer termed CD28 responsive element CD28RE). Tax activation of the CD28RE is partially mediated by a member of the nuclear facto
Myasthenia gravis induces the activation and maturation of lymphocytes in thymoma.: J Clin Immunol. 1996 Jul;16(4):190-7. Unique Identifier : AIDSLINE MED/96437573; Takahashi K; Monden Y; Saito S; Kamamura Y; Uyama T; Second Department of Surgery, School of Medicine, University of; Tokushima, Japan.; The biological differences between lymphocytes separated from thymoma patients with myasthenia gravis (MG) and those separated from thymoma patients without MG was examined. We investigated whether lymphocytes in thymoma (Th-L) of patients with and without MG could react to interleukin-2 (
Interleukin-10 (IL-10) secretion in systemic lupus erythematosus and rheumatoid arthritis: IL-10-dependent CD4+CD45RO+ T cell-B cell antibody synthesis.: J Clin Immunol. 1996 Jul;16(4):198-207. Unique Identifier : AIDSLINE MED/96437574; al-Janadi M; al-Dalaan A; al-Balla S; al-Humaidi M; Raziuddin S; Department of Internal Medicine (Rheumatology), King Saud University,; College of Medicine, Abha, Saudi Arabia.; Interleukin-10 (IL-10) is a major immunoregulatory cytokine and has a multitude of immunomodulatory effects in the immune system. In this study, we have examined the secretion and in vitro function of IL-10 in B cell hyperactivity in antibody production in two common autoimmune diseases, systemic lupus erythematosus S
Amelioration of experimental systemic lupus erythematosus (SLE) by retrovirus infection.: J Clin Immunol. 1996 Jul;16(4):230-6. Unique Identifier : AIDSLINE MED/96437578; Mittleman BB; Morse HC 3rd; Payne SM; Shearer GM; Mozes E; National Cancer Institute, National Institutes of Health, Bethesda,; Maryland 20893, USA.; Experimental SLE can be induced in susceptible 129/J mice by immunization with a human anti-DNA antibody bearing a common idiotype designated 16/6 Id. Immunized mice develop autoantibodies, leukopenia, proteinuria, and immune complex deposits in renal glomeruli. Case reports have described clinical improvement in SLE
Hyperimmunoglobulinemia E syndrome in HIV infection.: J Am Acad Dermatol. 1997 Jan;36(1):106-7. Unique Identifier : AIDSLINE MED/97149465; Blanche P; Bachmeyer C; Buvry C; Sicard D; Internal Medicine Service, Hopital Cochin, Paris, France.
Systemic cyclosporine and low-dose prednisone in the treatment of chronic severe alopecia areata: a clinical and immunopathologic evaluation.: J Am Acad Dermatol. 1997 Jan;36(1):114-7. Unique Identifier : AIDSLINE MED/97149469; Shapiro J; Lui H; Tron V; Ho V; Division of Dermatology, Faculty of Medicine, University of British; Columbia, Vancouver, Canada.
Clinical and histologic spectrum of human T-cell lymphotropic virus type I-associated lymphoma involving the skin [letter; comment]: J Am Acad Dermatol. 1997 Jan;36(1):133-4. Unique Identifier : AIDSLINE MED/97149477; Kikuchi A
Scabies in HTLV-I seropositive patients [letter; comment]: J Am Acad Dermatol. 1997 Jan;36(1):134-5. Unique Identifier : AIDSLINE MED/97149478; del Giudice P
Electron microscopy in AIDS-related infectious diseases. I. Acanthamoebiasis.: J Dermatol. 1996 Nov;23(11):773-7. Unique Identifier : AIDSLINE MED/97145028; Hashimoto K; Miner J; Department of Dermatology & Syphilology, Wayne State University School; of Medicine, Detroit, MI 48201, USA.
Dual role of HIV Tat in regulation of apoptosis in T cells.: J Immunol. 1997 Jan 15;158(2):1014-9. Unique Identifier : AIDSLINE MED/97146077; McCloskey TW; Ott M; Tribble E; Khan SA; Teichberg S; Paul MO; Pahwa S; Verdin E; Chirmule N; Department of Pediatrics, North Shore University Hospital-Cornell; University Medical College, Manhasset, NY 11030, USA.; Apoptosis has been suggested to be one of the major mechanisms of depletion of CD4+ T cells in HIV-1-infected individuals. Remarkably, HIV-1-infected cells appear protected from apoptosis, whereas bystander cells show increased apoptosis in lymph nodes of infected individuals. In this work, we present evidence that th
Superantigen-mediated deletion of specific T cell receptor V beta subsets in the SCID-hu Thy/Liv mouse is induced by staphylococcal enterotoxin B, but not HIV-1.: J Immunol. 1997 Jan 15;158(2):544-9. Unique Identifier : AIDSLINE MED/97146019; Komanduri KV; Salha MD; Sekaly RP; McCune JM; Gladstone Institute of Virology and Immunology, San Francisco, CA; 94141, USA.; Infection by HIV-1 has been associated with perturbations in the TCR V beta repertoire, suggesting the involvement of a superantigen. Among the hallmarks of superantigens is the capacity to delete T cells bearing specific TCR V beta families in the developing thymus. To verify the presence of a superantigen in HIV-1,
The role of B7-1 and LFA-3 in costimulation of CD8+ T cells.: J Immunol. 1997 Jan 15;158(2):637-42. Unique Identifier : AIDSLINE MED/97146031; Parra E; Wingren AG; Hedlund G; Kalland T; Dohlsten M; The Wallenberg Laboratory, Department of Cell and Molecular Biology,; University of Lund, Sweden.; This study compares the ability of LFA-3 (CD58) and B7-1 (CD80) ligands to provide costimulatory signals for superantigen SAg)-stimulated CD8+ and CD4+ T cells. We show that B7-1 and LFA-3 costimulation activate CD8+ T cells to proliferation, cytokine production ( IL-2 ,
Differential effects of IL-12 receptor blockade with IL-12 p40 homodimer on the induction of CD4+ and CD8+ IFN-gamma-producing cells.: J Immunol. 1997 Jan 15;158(2):643-8. Unique Identifier : AIDSLINE MED/97146032; Piccotti JR; Chan SY; Li K; Eichwald EJ; Bishop DK; Department of Surgery, University of Michigan School of Medicine, Ann; Arbor 48109, USA.; The role of IL-12 role in regulating Th1/Th2 balance is attributed in part to the ability of this cytokine to induce IFNgamma production by NK and Th1 cells, which in turn promotes Th1 and inhibits Th2 development. In the present study, the requirement for IL-12 in the development of alloantigen-reactive Th1 was asses
CD28 costimulation promotes the production of Th2 cytokines.: J Immunol. 1997 Jan 15;158(2):658-65. Unique Identifier : AIDSLINE MED/97146034; Rulifson IC; Sperling AI; Fields PE; Fitch FW; Bluestone JA; Ben May Institute for Cancer Research, Department of Pathology,; University of Chicago, IL 60637, USA.; CD28 ligation augments TCR-mediated proliferation, IL-2 production, and T cell survival. However, the role of CD28 costimulation in T cell differentiation remains controversial. To address this issue, CD28+ and CD28-deficient TCR alphabeta transgenic (Tg) mice were use
Identification of IL-4 promoter elements conferring Th2-restricted expression during T helper cell subset development.: J Immunol. 1997 Jan 15;158(2):765-73. Unique Identifier : AIDSLINE MED/97146046; Wenner CA; Szabo SJ; Murphy KM; Department of Pathology, Washington University School of Medicine, St.; Louis, MO 63110, USA.; Selective cytokine gene expression by T cell subsets underlies polarization of cellular and humoral immune responses. Our interest has been to define the molecular basis for restricted cytokine expression by Th1 and Th2 cells. IL-4 is selectively expressed by Th2 cells, providing a model for Th2-specific gene expressi
Antagonism of vaccine-induced HIV-1-specific CD4+ T cells by primary HIV-1 infection: potential mechanism of vaccine failure.: J Immunol. 1997 Jan 15;158(2):807-15. Unique Identifier : AIDSLINE MED/97146051; Kent SJ; Greenberg PD; Hoffman MC; Akridge RE; McElrath MJ; Department of Medicine, University of Washington School of Medicine,; Seattle 98145, USA.; Prior immunity to HIV-1 elicited by vaccination may modify subsequent responses upon exposure to infectious HIV-1. An HIV-1-uninfected person entered in a vaccine trial that included immunizations to HIV-1(LAI) envelope with a recombinant vaccinia vector and recombinant protein developed envelope-specific CD4+ T cell
In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen.: J Immunol. 1997 Jan 15;158(2):816-26. Unique Identifier : AIDSLINE MED/97146052; Kim JJ; Ayyavoo V; Bagarazzi ML; Chattergoon MA; Dang K; Wang B; Boyer JD; Weiner DB; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia 19104, USA.; Recent studies support the importance of investigating a DNA vaccination approach for the immunologic control of HIV-1. In this regard, it may be important to specifically engineer immune responses in order to improve on first generation vaccine attempts. Especially for HIV, induction of cell-mediated immunity may be
Intranasal immunization with CTL epitope peptides from HIV-1 or ovalbumin and the mucosal adjuvant cholera toxin induces peptide-specific CTLs and protection against tumor development in vivo.: J Immunol. 1997 Jan 15;158(2):834-41. Unique Identifier : AIDSLINE MED/97146054; Porgador A; Staats HF; Faiola B; Gilboa E; Palker TJ; Department of Experimental Surgery, Duke University Medical Center,; Durham, NC 27710, USA.; To evaluate the ability of mucosal immunization protocols using peptide immunogens to induce CTL responses, BALB/c and C57BL/6 mice were immunized intranasally (i.n.) with peptides corresponding to a known CTL epitope in HIV-1 glycoprotein 120 or OVA, respectively, and the mucosal adjuvant cholera toxin (CT). Intranas
T helper 1 effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease.: J Immunol. 1997 Jan 15;158(2):962-7. Unique Identifier : AIDSLINE MED/97146070; D'Elios MM; Manghetti M; De Carli M; Costa F; Baldari CT; Burroni D; Telford JL; Romagnani S; Del Prete G; Institute of Internal Medicine and Immunoallergology, University of; Florence, Italy.; Chronic antral gastritis following Helicobacter pylori (Hp) infection is characterized by a cellular inflammatory infiltrate whose cytokines may represent a host-dependent factor influencing the outcome of the infection. The pattern of cytokines produced by the immunologically active cells in the gastric antrum was an
In vitro separation and expansion of CD4 lymphocytes from HIV-infected individuals without activation of HIV infection.: J Immunol Methods. 1997 Jan 15;200(1-2):107-12. Unique Identifier : AIDSLINE MED/97158589; Nielsen SD; Nielsen JO; Hansen JE; Laboratory for Infectious Diseases, Hvidovre Hospital, Denmark.; In order to offer a gene therapy-based treatment against AIDS, it is likely to be necessary to harvest and culture CD4 cells from HIV-positive patients without activating the HIV infection. We have used a magnetic cell sorting (MACS) system to enrich CD4 cells. Using positive selection, CD4 cells from a total of 14 pa
Induction of antigen-specific isotype switching by in vitro immunization of human naive B lymphocytes.: J Immunol Methods. 1997 Jan 15;200(1-2):181-90. Unique Identifier : AIDSLINE MED/97158597; Zafiropoulos A; Andersson E; Krambovitis E; Borrebaeck CA; Laboratory of Applied Biochemistry and Immunology, Institute of; Molecular Biology and Biotechnology, Heraklion, Greece.; The use of in vitro immunization technology for the generation of human antigen-specific antibodies has essentially resulted in low affinity IgM antibodies, resembling an in vivo primary immune response. We now describe a detailed reproducible protocol for a two-step in vitro immunization, which yields isotype switche
Optimisation of a peptide-based indirect ELISA for the detection of antibody in the serum of HIV-1 seropositive patients.: J Immunol Methods. 1997 Jan 15;200(1-2):79-88. Unique Identifier : AIDSLINE MED/97158586; Brown L; Westby M; Souberbielle BE; Szawlowski PW; Kemp G; Hay P; Dalgleish AG; Division of Oncology, St. George's Hospital Medical School, London,; UK.; A modified peptide-based indirect ELISA technique for the detection of HIV-1 specific antibodies in the sera of HIV-1 seropositive individuals is described. We found that the reduction of non-specific binding of HIV-1 seropositive sera to the ELISA plate was essential for the reliable detection of serum antibodies in
N-acetyl-L-cysteine-induced up-regulation of HIV-1 gene expression in monocyte-derived macrophages correlates with increased NF-kappaB DNA binding activity.: J Leukoc Biol. 1997 Jan;61(1):33-9. Unique Identifier : AIDSLINE MED/97153244; Nottet HS; Moelans II; de Vos NM; de Graaf L; Visser MR; Verhoef J; Eijkman-Winkler Institute of Medical Microbiology, University of; Utrecht, The Netherlands.; Nuclear factor kappaB (NF-kappaB) is an important cellular regulator of human immunodeficiency virus (HIV) gene expression. In T cells, N-acetyl-L-cysteine (NAC) inhibits the induction of NF-kappaB and transcription of HIV-1. However, NAC up-regulates HIV-1 replication in monocyte-derived macrophages (MDM). In this st
Cathepsin G binds to human lymphocytes.: J Leukoc Biol. 1997 Jan;61(1):73-9. Unique Identifier : AIDSLINE MED/97153249; Yamazaki T; Aoki Y; Department of Nutrition and Biochemistry, The Institute of Public; Health, Tokyo, Japan.; Cathepsin G is a serine protease located in the azurophil granules of neutrophils. We have shown previously that cathepsin G stimulates human lymphocytes. In this study, we demonstrate that cathepsin G exhibits specific, saturable and reversible binding to lymphocytes: B cells, CD4+ T cells, CD8+ T cells, and natural
Replacement of pre-T cell receptor signaling functions by the CD4 coreceptor.: J Exp Med. 1997 Jan 6;185(1):121-30. Unique Identifier : AIDSLINE MED/97149440; Norment AM; Forbush KA; Nguyen N; Malissen M; Perlmutter RM; Department of Immunology, University of Washington, Seattle 98195,; USA.; An important checkpoint in early thymocyte development ensures that only thymocytes with an in-frame T cell receptor for antigen beta (TCR-beta) gene rearrangement will continue to mature. Proper assembly of the TCR-beta chain into the pre-TCR complex delivers signals through the src-family protein tyrosine kinase p56
T helper subset differentiation in the absence of invariant chain.: J Exp Med. 1997 Jan 6;185(1):31-41. Unique Identifier : AIDSLINE MED/97149431; Brown DR; Swier K; Moskowitz NH; Naujokas MF; Locksley RM; Reiner SL; Department of Medicine, Gwen Knapp Center for Lupus & Immunology; Research, University of Chicago, Illinois 60637, USA.; The outcome of murine infection with Leishmania major is regulated by major histocompatibility complex class II-restricted T helper cells. Invariant chain-deficient (Ii -/-) mice have impaired ability to present major histocompatibility complex class II-restricted antigens, and reduced numbers of CD4+ T cells. Despite
Macrophage-dependent apoptosis of CD4+ T lymphocytes from HIV-infected individuals is mediated by FasL and tumor necrosis factor.: J Exp Med. 1997 Jan 6;185(1):55-64. Unique Identifier : AIDSLINE MED/97149433; Badley AD; Dockrell D; Simpson M; Schut R; Lynch DH; Leibson P; Paya CV; Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota; 55901, USA.; Apoptosis of bystander uninfected CD4+ T lymphocytes by neighboring HIV-infected cells is observed in cell culture and in lymphoid tissue of HIV-infected individuals. This study addresses whether antigen-presenting cells such as human macrophages mediate apoptosis of CD4+ T cells from HIV-infected individuals. Uninfec
Interleukin-4 protects against a genetically linked lupus-like autoimmune syndrome.: J Exp Med. 1997 Jan 6;185(1):65-70. Unique Identifier : AIDSLINE MED/97149434; Santiago ML; Fossati L; Jacquet C; Muller W; Izui S; Reininger L; Institut National de la Sante et de la Recherche Medicale U 291,; F-34197 Montpellier, France.; Interleukin-4 (IL-4) provides support for humoral immune responses through upregulation of T helper (Th) type 2 cell differentiation, but it is not known whether IL-4 promotes antibody-mediated autoimmune diseases such as systemic lupus erythematosus (SLE). Here, we show that the constitutive expression of an IL-4 tra
Membrane tumor necrosis factor (TNF) induced cooperative signaling of TNFR60 and TNFR80 favors induction of cell death rather than virus production in HIV-infected T cells.: J Exp Med. 1997 Jan 6;185(1):81-90. Unique Identifier : AIDSLINE MED/97149436; Lazdins JK; Grell M; Walker MR; Woods-Cook K; Scheurich P; Pfizenmaier K; Division Pharma, Ciba, Basel, Switzerland.; Tumor necrosis factor (TNF) and lymphotoxin (LT) are highly pleiotropic cytokines that play a central role in regulating HIV-1 replication. These cytokines express their activities through two membrane receptors, TNFR60 (p55-60) and TNFR80 p75-80). In the present study we have demonstrated by means of antagonistic and
Antibody-dependent cell-mediated cytotoxicity (ADCC) in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) [published erratum appears in J Neurol Sci 1997 Apr 15;147(2):221]: J Neurol Sci. 1996 Oct;142(1-2):65-9. Unique Identifier : AIDSLINE MED/97058402; Fujihara K; Itoyama Y; Yu F; Kubo C; Goto I; Department of Neurology, Kyushu University, Fukuoka, Japan.; Defects in immune surveillance mechanisms may allow increased replication of human T-lymphotropic virus type I (HTLV-I) in peripheral blood mononuclear cells in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP). To explore this possibility, antibody-dependent cell-mediated cytotoxicity ADCC) against
Effects of social support, stress, and level of illness on caregiving of children with AIDS.: J Pediatr Nurs. 1996 Dec;11(6):347-58. Unique Identifier : AIDSLINE MED/97145781; Hughes CB; Caliandro G; College of Nursing, Seton Hall University, South Orange, NJ 07079,; USA.; The purpose of this descriptive correlational study was to explore the relationship between social support, stressors, level of illness, and perceived caregiver burden in caregivers of children with HIV/AIDS. Instruments used were: (1) the Classification System for Human Immunodeficiency Virus (HIV) Infection in Child
Chronic and aggressive plantar verrucae in a patient with HIV.: J Am Podiatr Med Assoc. 1996 Nov;86(11):555-8. Unique Identifier : AIDSLINE MED/97120990; Soltani SK; Kenyon E; Barbosa P; Midway Hospital, Los Angeles, CA, USA.
Impoverished women at risk for AIDS. Social support variables.: J Psychosoc Nurs Ment Health Serv. 1996 Nov;34(11):31-9. Unique Identifier : AIDSLINE MED/97082105; Nyamathi A; Flaskerud J; Leake B; Chen S; University of California, Los Angeles, School of Nursing 90095-6918,; USA.; 1. Among impoverished and homeless individuals, little is known about the impact of social support, defined as emotional, informational, and tangible help that may have health-sustaining and stress-reducing functions. 2. A lack of positive social support, unemployment, and the prevalence of poor physical health and ps
Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant.: J Mol Biol. 1996 Dec 20;264(5):1085-100. Unique Identifier : AIDSLINE MED/97153342; Das K; Ding J; Hsiou Y; Clark AD Jr; Moereels H; Koymans L; Andries K; Pauwels R; Janssen PA; Boyer PL; Clark P; Smith RH Jr; Kroeger Smith MB; Michejda CJ; Hughes SH; Arnold E; Center for Advanced Biotechnology and Medicine and Department of; Chemistry, Rutgers University, Piscataway, NJ 08854-5638, USA.; Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase RT) is an important target for chemotherapeutic agents used in the treatment of AIDS; the TIBO compounds are potent non-nucleoside inhibitors of HIV-1 RT (NNRTIs). Crystal structures of HIV-1 RT complexed with 8-Cl TIBO (R86183, IC50 = 4.6 nM) and 9-Cl
Three-dimensional structure of the HTLV-II matrix protein and comparative analysis of matrix proteins from the different classes of pathogenic human retroviruses.: J Mol Biol. 1996 Dec 20;264(5):1117-31. Unique Identifier : AIDSLINE MED/97153344; Christensen AM; Massiah MA; Turner BG; Sundquist WI; Summers MF; Department of Biochemistry, University of Utah, Salt Lake City 84132,; USA.; The matrix protein performs similar roles in all retroviruses, initially directing membrane localization of the assembling viral particle and subsequently forming a stable structural shell associated with the inner surface of the mature viral membrane. Although conserved structural elements are likely to perform these
Structural change in Rev responsive element RNA of HIV-1 on binding Rev peptide.: J Mol Biol. 1996 Dec 20;264(5):863-77. Unique Identifier : AIDSLINE MED/97153327; Peterson RD; Feigon J; Department of Chemistry and Biochemistry and Molecular Biology; Institute, University of California, Los Angeles 90095, USA.; The HIV-1 Rev responsive element (RRE) high-affinity binding site was studied by homonuclear and heteronuclear NMR. Two Rev binding element (RBE) RNA oligonucleotides were used as model systems in this study: RBE3, which contains the wild-type Rev high-affinity binding site, and RBE3-A which is identical except for th
Upregulation of Th-2 cytokine receptors in atopy- and nonatopy-associated chronic sinusitis.: J Otolaryngol. 1996 Oct;25(5):317-21. Unique Identifier : AIDSLINE MED/97058371; Kotsimbos TC; al Ghamdi K; Small P; Frenkiel S; Hamid QA; Meakins-Christie Laboratories, Montreal, Quebec.; OBJECTIVE: This study was conducted to investigate the expression of alpha IL5 and alpha GM-CSF receptors (alpha IL5r and alpha GM-CSFr) mRNA in the paranasal sinus mucosa of atopic and nonatopic subjects with chronic sinusitis compared to controls. DESIGN: This was a prospective study of patients presenting with the
Plague and AIDS in literature.: JAMA. 1997 Feb 5;277(5):437-8. Unique Identifier : AIDSLINE MED/97163360; Yom SS; Graduate School of Arts and Sciences, University of Pennsylvania; School of Medicine, USA.
Howard Temin memorial lectureship. Molecular biology of HTLV-1: deregulation of host cell gene expression and cell cycle.: Leukemia. 1997 Jan;11(1):14-5. Unique Identifier : AIDSLINE MED/97154694; Yoshida M; Department of Cellular and Molecular Biology, Institute of Medical; Science, University of Tokyo, Japan.
Response duration and recovery of CD4+ lymphocytes following deoxycoformycin in interferon-alpha-resistant hairy cell leukemia: 7-year follow-up.: Leukemia. 1997 Jan;11(1):42-7. Unique Identifier : AIDSLINE MED/97154699; Seymour JF; Talpaz M; Kurzrock R; Department of Clinical Haematology and Medical Oncology, The Royal; Melbourne Hospital, Parkville, Australia.; The long-term outcome of patients with hairy cell leukemia resistant to interferon-alpha (IFN-alpha) following treatment with deoxycoformycin (DCF) was examined, and the kinetics of recovery of lymphocyte subsets and factors influencing the rate of recovery investigated. Between May 1986 and May 1989, 15 patients with
[Rapid and slow progression of the infection by the type 1 human immunodeficiency virus in a population of seropositive subjects in Madrid (see comments)]: Med Clin (Barc). 1996 Dec 7;107(20):761-6. Unique Identifier : AIDSLINE MED/97152664; Soriano V; Martin R; del Romero J; Castilla J; Bru F; Bravo R; Gutierrez M; Martinez P; Valencia E; Garcia S; Mas A; Moreno V; Laguna F; Rodriguez C; Sabin ML; Gonzalez-Lahoz J; Servicio de Enfermedades Infecciosas, CIC, Instituto de Salud Carlos; III, Madrid.; BACKGROUND: The rate of progression to AIDS in HIV-1 infected subjects is variable, and circumstances associated with more rapid or slow development of severe immunodeficiency might be grouped in three categories; environmental cofactors, host features, and particular virulence of the virus itself. Currently, it is no
[Patients infected with HIV-1: why some speedsters and others marathon runners? (editorial; comment) (published erratum appears in Med Clin (Barc) 1996 Jul 6;107(6):230)]: Med Clin (Barc). 1996 Dec 7;107(20):776-8. Unique Identifier : AIDSLINE MED/97152667; Gatell JM
[Myositis caused by Pleistophora in a patient with AIDS]: Med Clin (Barc). 1996 Dec 7;107(20):779-81. Unique Identifier : AIDSLINE MED/97152668; Grau A; Valls ME; Williams JE; Ellis DS; Muntane MJ; Nadal C; Servicio de Medicina Interna, Hospital de Figueres, Girona.; The third case in the literature is reported of an infection produced by Pleistophora. The clinical detail of the three cases are discussed. Two of the patients-including the reported one-were infected by HIV. All patients suffered from myositis with fever, resting and at palpation myalgia, and progressive weakness. B
[Fever and abdominal pain in a patient with human immunodeficiency virus infection and Burkitt's lymphoma (clinical conference)]: Med Clin (Barc). 1996 Dec 7;107(20):788-94. Unique Identifier : AIDSLINE MED/97152670; Ribas MA; Munoz C; Servicio de Medicina Interna, Hospital de Son Dureta, Palma de; Mallorca.
Combination therapy in the management of HIV infection.: Methods Find Exp Clin Pharmacol. 1996;18 Suppl C:23-6. Unique Identifier : AIDSLINE MED/97157245; Vella S; Franca Pirillo M; Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy.
Adverse drug reactions in HIV positive hospitalized patients. A one-year drug surveillance program: study design.: Methods Find Exp Clin Pharmacol. 1996;18 Suppl C:27-8. Unique Identifier : AIDSLINE MED/97157246; Calvo G; Morros R; Mateu S; Torres F; Torrent J; Jane F; Service of Clinical Pharmacology, Hospital de Sant Pau, Spain.
Maryland women living with HIV/AIDS.: Md Med J. 1996 Dec;45(12):1027-30. Unique Identifier : AIDSLINE MED/97140954; Berger R; Division of AIDS Services, Baltimore County Health Department, USA.; Approximately one-quarter of the acquired immunodeficiency syndrome (AIDS) cases reported in Maryland are women. African-American women account for 80% or more of the cases in the Baltimore-Metropolitan area. Human immunodeficiency virus HIV)-positive women are frequently dealing with a constellation of social problem
Speakers Bureau continues to get more requests.: Mich Med. 1996 Nov;95(11):34. Unique Identifier : AIDSLINE MED/97134331; Seely T
Michigan AIDS Fraud Task Force.: Mich Med. 1996 Nov;95(11):35. Unique Identifier : AIDSLINE MED/97134332
Pregnant women and HIV.: Mich Med. 1996 Nov;95(11):36. Unique Identifier : AIDSLINE MED/97134333; Haveman JK Jr
Review of the impact on the activation of the human immunodeficiency virus type 1 of ultraviolet light.: Med Hypotheses. 1996 Jul;47(1):11-4. Unique Identifier : AIDSLINE MED/96416202; Duan Y; Kennedy SB 4th; Department of Biochemistry, University of Pennsylvania Dental School,; Philadelphia 19104, USA.; Acquired immune deficiency syndrome is a devastating disease with a high mortality rate and the failure of adequate therapy and vaccine stands in sharp contrast to the ultimate progress made in the biomedical sciences. We review the damaging effects of ultraviolet rays on the activation of the human immunodeficiency v
Pitfalls in the use of surrogate markers for human immunodeficiency virus disease: further evidence on pathogenesis.: Med Hypotheses. 1996 Jul;47(1):27-30. Unique Identifier : AIDSLINE MED/96416206; Allen AD; Hillis T; Vidikan P; Beer V; CytoDyn of New Mexico Inc., Santa Fe 87501, USA.; The administration of drugs to human immunodeficiency virus patients with a pronounced CD4+ T lymphocytopenia may cause non-specific binding of the murine antibodies used in flow cytometry. This has produced spurious reports of early thymocytes in the circulating blood of human immunodeficiency virus-infected individu
Could an aminoacridine interfere with the cellular mechanisms involved in the process of human immunodeficiency virus infection?: Med Hypotheses. 1996 Jul;47(1):43-7. Unique Identifier : AIDSLINE MED/96416210; Sotelo J; National Institute of Neurology and Neurosurgery of Mexico, Mexico; City, Mexico. jsotelo@servidor.unam.mx; Immune activation and synthesis of nucleic acids participate in the course of infection by human immunodeficiency virus. Aminoacridines, formally used as antiparasitic drugs, but almost abandoned nowadays for therapeutic use, are strong deoxyribonucleic acid chemoprotectors and lysosome stabilizers. Theoretically, the
Acquired immune deficiency syndrome: the glucocorticoid solution.: Med Hypotheses. 1996 Jul;47(1):49-54. Unique Identifier : AIDSLINE MED/96416211; Corley PA; Documented evidence supports the cortisol connection theory of acquired immune deficiency syndrome, linking glucocorticoid metabolism with immune function, and human immunodeficiency virus with them both. The peptide T subregion of gp 120 of human immunodeficiency virus apparently utilizes cellular melanocyte stimul
The eighth mystery of acquired immune deficiency syndrome and the Trojan horse' mechanism.: Med Hypotheses. 1996 Jul;47(1):55-64. Unique Identifier : AIDSLINE MED/96416212; Erlander SR; Erlander's Natural Products, Altadena, CA 91003, USA.; Human immunodeficiency virus protease inhibitors produce in acquired immune deficiency virus patients a decrease in both existing and new human immunodeficiency virus accompanied by an increase in CD4+ T cells. Yet these inhibitors are not capable of destroying exis
[Ubiquitous mycobacteria: clinical and microbiological aspects]: Med Klin. 1996 Oct 15;91(10):654-9. Unique Identifier : AIDSLINE MED/97080209; Schutt-Gerowitt H; Institut fur Medizinische Mik