1997

Single stand targeted triplex formation: physicochemical and biochemical properties of foldback triplexes.: J Biomol Struct Dyn. 1996 Aug;14(1):79-90. Unique Identifier : AIDSLINE MED/97031658; Kandimalla ER; Manning A; Agrawal S; Hybridon, Inc Worcester, MA 01605, USA.; Oligodeoxyribonucleotides containing both Watson-Crick and Hoogsteen hydrogen bonding domains joined by a nucleotide loop FTFOs) are studied for their binding affinity and specificity to the DNA and RNA single-stranded targets. Thermal denaturation studies reveal that FTFOs have high binding affinity for their targets
Model compounds in elucidating the structural basis of HIV retrovirus activity. Synthesis of trisodium O-monoalkyl- and O-monoaryldiphosphates.: Boll Chim Farm. 1996 Apr;135(4):229-31. Unique Identifier : AIDSLINE MED/97070091; Gregan F; Kettmann V; Novomesky P; Misikova E; Faculty of Pharmacy, Comenius University, Bratislava, Slovakia.; Trisodium salts of O-methyl, O-butyl, O-phenyl, and O-(4-nitrophenyl)diphosphonic acids were prepared by reaction of sodium dimethylamido-O-(2-cyanoethyl)phosphate with O-alkyl-, and O-arylphosphonic acid. In an effort to obtain anhydrous salts of the acids, besides the conventional method using aqueous sodium hydroxi
Fluorometric assay for DNA polymerases and reverse transcriptase.: Biotechniques. 1996 Oct;21(4):664, 666, 668, 670, 672. Unique Identifier : AIDSLINE MED/97046297; Seville M; West AB; Cull MG; McHenry CS; Enzyco Inc., Denver, CO 80206, USA.; We report a quick, easy and inexpensive fluorometric assay that measures the activity of replication enzymes using Pico-GreenTM. The systems tested include replication of the natural template M13 Gori by E. coli DNA polymerase III holoenzyme and the replication of a synthetic homopolymer by human immunodeficiency viru
[Cerebrovascular disease as a form of presentation of HIV infection]: Neurologia. 1996 Nov;11(9):346-9. Unique Identifier : AIDSLINE MED/97139370; Palomeras E; Roquer J; Servicio de Neurologia, Hospital del Mar, Barcelona.; Several necropsy reports have suggested that cerebral vascular disease (CVD) is more frequent in HIV positive patients than in HIV negative individuals of the same age, although clinical signs are rare. We describe three patients for whom CVD was the clinical manifestation that led to diagnoses of HIV infection. The p
Inhibitors of HIV protease: unique non-peptide active site templates.: J Mol Recognit. 1996 Mar-Apr;9(2):139-42. Unique Identifier : AIDSLINE MED/97031899; Tait BD; Domagala J; Ellsworth EL; Ferguson D; Gajda C; Hupe D; Lunney EA; Tummino PJ; Department of Chemistry, Parke-Davis Pharmaceutical Research Division; of the Warner-Lambert Company, Ann Arbor, Michigan 48106, USA.; New templates were designed and prepared which straddle the active site of HIV-1 protease. These templates were designed to be flexible scaffolds upon which substituents could be appended to fill the pockets of HIV protease. The new templates prepared and analysed were 4-hydroxy-5H-furan-2-ones, 4-hydroxy-5,6-dihydr
Design and analysis of RNA structure-specific agents as potential antivirals.: J Mol Recognit. 1996 Mar-Apr;9(2):187-96. Unique Identifier : AIDSLINE MED/97031906; Wilson WD; Ratmeyer L; Zhao M; Ding D; McConnaughie AW; Kumar A; Boykin DW; Department of Chemistry, Georgia State University, Atlanta 30303, USA.; A number of pathogenic RNA viruses, such as HIV-1, have extensive folded RNA conformations with imperfect A-form duplexes that are essential for virus function, and could serve as targets for structure-specific antiviral drugs. A method for the discovery of such drugs involves evaluation of the interactions with RNA o
[Diarrhea in patients with AIDS]: Rev Esp Enferm Dig. 1996 Apr;88(4):280-6. Unique Identifier : AIDSLINE MED/97122818; Mones J; Gurgui M; Cadafalch J; Hospital de la Santa Creu i Sant Pau, Universidad Autonoma, Barcelona.
Developing a cost-effective media campaign addressing unprotected anal sex among gay men.: AIDS Educ Prev. 1996 Aug;8(4):285-93. Unique Identifier : AIDSLINE MED/97028633; Dawson C; Hartfield K; Seattle-King Country Department of Public Health AIDS Prevention; Project, WA, USA.; This paper describes the development and implementation of the Stella Seattle campaign, a media campaign targeting men who have unprotected anal sex with other men. Stella Seattle utilizes a serial cartoon strip format. Scenarios and characters in the strip are derived from local formative research on factors associat
Cognitive and emotional assessments of perceived risk for HIV among unmarried heterosexuals.: AIDS Educ Prev. 1996 Aug;8(4):294-307. Unique Identifier : AIDSLINE MED/97028634; Dolcini MM; Catania JA; Choi KH; Fullilove MT; Coates TJ; Department of Medicine, University of California, San Francisco 94105,; USA.; We examined perceived risk of contracting HIV using assessments of likelihood and worry in a probability sample of unmarried heterosexuals. Perceptions of the likelihood of contracting HIV and worry about HIV were only modestly correlated (r = .23), suggesting that they are different constructs. Far more respondents e
Self-reported risk factors for AIDS among homeless youth.: AIDS Educ Prev. 1996 Aug;8(4):308-22. Unique Identifier : AIDSLINE MED/97028635; Johnson TP; Aschkenasy JR; Herbers MR; Gillenwater SA; Survey Research Laboratory, University of Illinois at Chicago 60680,; USA.; This study assessed HIV risk behaviors in a sample of homeless youth in a large urban area and examined factors associated with these behaviors. Self-reported behaviors were assessed via interviews with 196 homeless youth in Chicago in all 10 urban shelters serving this group and in 5 street locations. Overall, 83.7%
Assessing reading level of drug users for HIV and AIDS prevention purposes.: AIDS Educ Prev. 1996 Aug;8(4):323-34. Unique Identifier : AIDSLINE MED/97028636; Johnson ME; Fisher DG; Davis DC; Cagle HH; Rhodes F; Booth R; Siegal H; Jones A; Department of Psychology, University of Alaska at Anchorage, Anchorage; 99508, USA.; Using the short form of the Woodcock Reading Mastery Test-Revised and the reading subtest of the Wide Range Achievement Test-Revised, the reading abilities of 284 male and 128 female drug users from five sites across the United States were evaluated. All subjects were participants in a
HIV-related concerns and behaviors among Hispanic women.: AIDS Educ Prev. 1996 Aug;8(4):335-42. Unique Identifier : AIDSLINE MED/97028637; Deren S; Shedlin M; Beardsley M; National Development and Research Institutes, Inc., New York, NY; 10013, USA.; Hispanic women whose sexual partners have other sexual partners may be at risk for HIV. A structured interview was administered to 106 Dominican and Puerto Rican women who reported that they knew or suspected that their partner had other partners. A subsample participated in qualitative interviews. The study assessed
Needs assessment for an urban native HIV and AIDS prevention program.: AIDS Educ Prev. 1996 Aug;8(4):343-51. Unique Identifier : AIDSLINE MED/97028638; Brassard P; Smeja C; Valverde C; Public Health Unit, Montreal General Hospital, QC, Canada.; At the request of Native community-based organizations in Montreal, a needs assessment for an HIV and AIDS education and prevention program for urban Natives was initiated. A five-session focus group concerning HIV and AIDS was attended by nine Native persons over a 2-month period. Data was collected using the guideli
Prevention implications of AIDS discourses among South African women.: AIDS Educ Prev. 1996 Aug;8(4):352-74. Unique Identifier : AIDSLINE MED/97028639; Strebel A; Department of Psychology, University of the Western Cape, Cape Town,; South Africa.; Social constructionist and feminist analyses have done much to extend the understanding of AIDS beyond the biomedical to include social accounts of the constitution of AIDS knowledge and meanings. However, these frameworks have not translated easily into realistic responses to the paradox of women being seen as respon
Assigning new meanings to traditional literature: illustrations for HIV educators.: AIDS Educ Prev. 1996 Aug;8(4):375-80. Unique Identifier : AIDSLINE MED/97028640; Leoutsakas D; Tampa AIDS Network, FL, USA.; Folk literature (folktales, fairy tales, and myths) has always had a psychological and sociological impact on humans. Parents and educators have been using stories from folk literature for generations to convey significant ideas and cultural values. With HIV being a major health concern, there is a need to establish d
Through the looking glass.: Nurs Stand. 1996 Nov 27;11(10):24-5. Unique Identifier : AIDSLINE MED/97154076; Moore O
Still alight.: Nurs Stand. 1996 Oct 30;11(6):17. Unique Identifier : AIDSLINE MED/97152115; Spence C; London Lighthouse.
AIDS research and prevention: a social representational approach.: Br J Med Psychol. 1996 Sep;69 ( Pt 3):169-90. Unique Identifier : AIDSLINE MED/97038378; Joffe H; Department of Psychology, University College London, UK.; The KABP paradigm (knowledge-attitude-belief-practice) dominates social scientific AIDS research and prevention programmes. This paper questions a number of the assumptions of the paradigm both theoretically and empirically. Having discussed a number of the paradigm s shortcomings, an alternative, a social representat
HIV and pregnancy.: Br J Obstet Gynaecol. 1996 Dec;103(12):1184-90. Unique Identifier : AIDSLINE MED/97122984; Johnstone FD; Department of Obstetrics and Gynaecology, University of Edinburgh.
A short autocomplementary sequence plays an essential role in avian sarcoma-leukosis virus RNA dimerization.: Biochemistry. 1996 Dec 24;35(51):16601-9. Unique Identifier : AIDSLINE MED/97141737; Fosse P; Motte N; Roumier A; Gabus C; Muriaux D; Darlix JL; Paoletti J; Unite de Biochimie-Enzymologie, Centre National de la Recherche; Scientifique Unite de Recherche Associee 147, Institut Gustave Roussy,; Villejuif, France.; Retroviral genomes consist of two identical RNA molecules joined noncovalently near their 5 -ends. Recently, two models have been proposed for RNA dimer formation on the basis of results obtained in vitro with human immunodeficiency virus type 1 RNA and Moloney murine leukemia virus RNA. It was first proposed that vir
A common structural motif in immunopotentiating peptides with sequences present in human autoantigens. Elicitation of a response mediated by monocytes and Th1 cells.: Biochim Biophys Acta. 1996 Dec 16;1317(3):183-91. Unique Identifier : AIDSLINE MED/97141984; Lopez-Moratalla N; Ruiz E; Lopez-Zabalza MJ; Santiago E; Department of Biochemistry, University of Navarra, Pamplona, Spain.; We have found a common structural motif in human autoantigens, heat shock proteins and viral proteins. Peptides modelled after sequences present in those molecules were synthesized and immunomodulating properties tested. They share a core of 15 amino acid residues and a common pattern ( 2-6-11 motif) characterized by
Selective endocytosis of fluorothymidine and azidothymidine coupled to LDL into HIV infected mononuclear cells.: Biochim Biophys Acta. 1996 Dec 16;1317(3):233-7. Unique Identifier : AIDSLINE MED/97141990; Mankertz J; Matthes E; Rokos K; von Baeyer H; Pauli G; Riedel E; Institut fur Biochemie, Fachbereich Chemie, Freie Universitat Berlin,; Germany.; Drug targeting via lipoproteins may be of benefit for use of cytotoxic drugs like fluorothymidine (FLT) or azidothymidine AZT ). Both drugs are potent inhibitors of the human immunodeficiency virus (HIV) reverse transcriptase and are used in the therap
Is an elevated level of serum lipoprotein (a) a risk factor for cardiovascular disease in CAPD patients?: Adv Perit Dial. 1996;12:266-71. Unique Identifier : AIDSLINE MED/97019406; Avram MM; Sreedhara R; Patel N; Chattopadhyay J; Thu T; Fein P; Division of Nephrology, Long Island College Hospital, Brooklyn, New; York, USA.; Cardiovascular disease (CVD) is the single most important cause of mortality in hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) patients. An increased lipoprotein (a) [Lp(a)] level in HD patients is associated with CVD. However, Lp(a) levels in CAPD patients are controversial, and their associat
Human immunodeficiency virus-related morbidity and mortality in injection drug users: should the AIDS definition be changed yet again? [editorial; comment]: Epidemiology. 1996 Nov;7(6):563-5. Unique Identifier : AIDSLINE MED/97055092; Royce R
Human immunodeficiency virus infection and infective endocarditis among injecting drug users [see comments]: Epidemiology. 1996 Nov;7(6):566-70. Unique Identifier : AIDSLINE MED/97055093; Manoff SB; Vlahov D; Herskowitz A; Solomon L; Munoz A; Cohn S; Willoughby SB; Nelson KE; Department of Epidemiology, Johns Hopkins University School of Hygiene; and Public Health, Baltimore, MD 21205, USA.; Human immunodeficiency virus (HIV) infection and infective endocarditis are serious complications of injection drug use. To determine whether HIV infection may increase the risk of endocarditis beyond that associated with drug injection, we performed a nested case-control study among injecting drug users taking part i
Differences in progression to AIDS between injection drug users and homosexual men with documented dates of seroconversion [see comments]: Epidemiology. 1996 Nov;7(6):571-7. Unique Identifier : AIDSLINE MED/97055094; Spijkerman IJ; Langendam MW; Veugelers PJ; van Ameijden EJ; Keet IP; Geskus RB; van den Hoek A; Coutinho RA; Municipal Health Service, Department of Public Health and Environment,; Amsterdam, The Netherlands.; We compared rates of progression to AIDS for 99 injection drug users and 120 homosexual men with documented dates of HIV-1 seroconversion. The crude risk of developing AIDS was higher among homosexual men than injection drug users [relative hazard RH) = 2.4; 95% confidence interval (CI) = 1.3-4.4]. The relative hazard
[Rhabdomyolysis and lumbosacral plexopathy in intravenous drug addict: report of a case]: An Med Interna. 1996 Feb;13(2):84-6. Unique Identifier : AIDSLINE MED/97106072; Diaz Guzman J; Pastor Valverde C; Gil Grande R; Alonso Ortiz A; Trueba Gutierrez JL; Servicio de Neurologia, Hospital Universitario Doce de Octubre,; Madrid.; There are several neuromuscular complications in the intravenous heroin addict (IHA). Someone may be due to direct toxic effect of the substance, but other ones may be associated to abuser s typical diseases (i.e. HIV infection). We present a 27 year-old IHA patient, HIV positive, that develop acute rhabdomyolisis wit
[Colony stimulating factors (G-CSF and GM-CSF): clinical update and usefulness in patients with HIV infection]: An Med Interna. 1996 Feb;13(2):87-90. Unique Identifier : AIDSLINE MED/97106073; Valencia Ortega ME; Camacho Siles J; Gonzalez Lahoz J; Servicio de Enfermedades Infecciosas, Instituto de Salud Carlos III,; Madrid.
[Pyomyositis and AIDS (letter)]: An Med Interna. 1996 Feb;13(2):97-8. Unique Identifier : AIDSLINE MED/97106079; Gregorio Vila A; Pedro-Botet Montoya ML; Sopena Galindo N; Matas Andreu L; Sabria Leal M
Treatment of Burkitt's lymphoma in HIV-positive patients.: Biomed Pharmacother. 1996;50(9):447-50. Unique Identifier : AIDSLINE MED/97145474; Straus DJ; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New; York, NY 10021, USA.; Many Burkitt s-type non-Hodgkin lymphomas (NHL) in patients without HIV infection are curable with current brief high-dose combination chemotherapy regimens. Burkitt s-type lymphomas (BL) comprise 30-40% of HIV-associated NHL. Their morphologic, clinical, cytogenetic and molecular genetic characteristics are similar t
The association of the Epstein-Barr virus with malignant lymphoma.: Biomed Pharmacother. 1996;50(9):459-67. Unique Identifier : AIDSLINE MED/97145476; Chang KL; Weiss LM; Division of Pathology, City of Hope National Medical Center, Duarte,; CA 91010-0269, USA.; The Epstein-Barr virus, a human herpesvirus, has been found in the neoplastic cells of numerous lymphoid malignancies, including Burkitt s lymphoma, immunodeficiency-associated lymphoproliferative disorders, nasal T/NK lymphoma, and Hodgkin s disease. The available data suggest that Epstein-Barr virus contributes to t
Complications and outcome of percutaneous endoscopic gastrostomy in different patient groups.: J Gastroenterol Hepatol. 1996 Sep;11(9):835-9. Unique Identifier : AIDSLINE MED/97044891; Chowdhury MA; Batey R; Department of Medicine, John Hunter Hospital, Newcastle, New South; Wales, Australia.; A retrospective study of percutaneous endoscopic gastrostomy PEG) was performed to evaluate the complications of PEG and determine the role of prophylactic antibiotics in preventing early wound infection and to evaluate the outcome of patients in different groups (neurological disease, head injury, AIDS). Percutaneous
Identification of a serpin specifically expressed in multipotent and bipotent hematopoietic progenitor cells and in activated T cells.: Blood. 1997 Jan 1;89(1):108-18. Unique Identifier : AIDSLINE MED/97132924; Hampson IN; Hampson L; Pinkoski M; Cross M; Heyworth CM; Bleackley RC; Atkinson E; Dexter TM; CRC Department of Experimental Haematology, Paterson Institute of; Cancer Research, Christie Hospital, Manchester, UK.; We have identified a gene that has a high level of mRNA expression in undifferentiated, multipotential hematopoietic cells (FDCP-Mix) and that downregulates both transcript and protein, as these cells are induced to differentiate into mature myeloid cells. Sequence analysis of this gene has identified it as a serine p
Hemophilia and nonprogressing human immunodeficiency virus type 1 infection.: Blood. 1997 Jan 1;89(1):191-200. Unique Identifier : AIDSLINE MED/97132933; Vicenzi E; Bagnarelli P; Santagostino E; Ghezzi S; Alfano M; Sinnone MS; Fabio G; Turchetto L; Moretti G; Lazzarin A; Mantovani A; Mannucci PM; Clementi M; Gringeri A; Poli G; DIBIT, Department of Infectious Diseases, San Raffaele Scientific; Institute, Milan, Italy.; Seven of 112 hemophiliacs infected with human immunodeficiency virus type-1 (HIV-1) before 1986 through contaminated plasma products are currently healthy, with CD4 T-cell counts above 500 cells/microL, and have never received antiretroviral therapy long-term nonprogressors [LTNPs]). Seven age and sex-matched hemophil
Extensive latent retroviral infection in bone marrow of patients with HTLV-I-associated neurologic disease [letter]: Blood. 1997 Jan 1;89(1):346-8. Unique Identifier : AIDSLINE MED/97132953; Levin MC; Krichavsky M; Fox RJ; Lehky T; Jacobson S; Fox C; Kleghorn F; White J; Young N; Edwards RJ; Jack NE; Bartholomew C
Effects of occupational exposure to mercury vapors on T-cell and NK-cell populations.: Arch Med Res. 1996 Winter;27(4):503-7. Unique Identifier : AIDSLINE MED/97140737; Moszczynski P; Rutowski J; Slowinski S; Bem S; Jakus-Stoga D; International Institute of Universalistic Medicine, Warsaw, Poland.; The counts of lymphocytes, (CD3+) T-cells, (CD4+) T-helper and CD 8+) T-suppressor and (CD 16+) NK-cells were determined in the peripheral blood of 81 males with a history of occupational exposure to metallic mercury vapors and in 36 males without this exposure. For the determination of T-cell populations monoclonal a
Does HIV test result influence methadone maintenance treatment retention?: J Subst Abuse. 1996;8(2):263-9. Unique Identifier : AIDSLINE MED/97035009; Wimbush J; Amicarelli A; Stein MD; Department of Medicine, Brown University, USA.; We compared groups of opioid users new to methadone maintenance to determine if persons who first learn that they are HIV-seropositive in a drug treatment program are more likely to drop out of treatment than persons who learn they are seronegative. We found no difference in patients continuation in methadone treatme
A simplified procedure for the purification of trichosanthin (a type 1 ribosome inactivating protein) from Trichosanthes kirilowii root tubers.: Protein Expr Purif. 1996 Mar;7(2):143-6. Unique Identifier : AIDSLINE MED/97005269; Bhatia N; McDonald KA; Jackman AP; Dandekar AM; Department of Chemical Engineering and Materials Science, University; of California at Davis 95616, USA.; A one step rapid and simple purification procedure for trichosanthin, a type 1 ribosome inactivating protein, from root tubers of Trichosanthes kirilowii has been developed using cation-exchange perfusion chromatography. The identity of the protein has been confirmed by its size, immunoreactivity, and sequence informa
Important statistics missing [letter]: Can Fam Physician. 1996 Dec;42:2341-2, 2344. Unique Identifier : AIDSLINE MED/97124712; DuBois MJ
Intravenous injections of the ribosome inactivating protein trichosanthin did not affect methionine enkephalin and beta-endorphin levels in the mouse brain and pituitary.: Biochem Mol Biol Int. 1996 Aug;39(5):985-9. Unique Identifier : AIDSLINE MED/97019541; Ng TB; Kwong WH; Yeung HW; Department of Biochemistry, Faculty of Medicine, Chinese University of; Hong Kong, Hong Kong.; The effect of trichosanthin on levels of the neuropeptides beta-endorphin (beta-EP) and methionine enkephalin (met-EK) in the mouse brain and pituitary was investigated. Mature male ICR mice were divided into two groups. One group received intravenous injections of physiological saline and served as the control. Anoth
The manifestation and management of staff countertransference on a pediatric AIDS team.: Bull Menninger Clin. 1996 Spring;60(2):206-18. Unique Identifier : AIDSLINE MED/97010359; Mayers AM; Svartberg M; Norwegian Center for Child Research, University of Trondheim, Norway.; The authors discuss the countertransference reactions that arise in staff who work in a hospital outpatient clinic with children with HIV and AIDS. Countertransference feelings such as guilt, anger, and helplessness can be easily aroused when working with a young, impoverished, dying population. Factors that precipita
Simultaneous determination of L-702,007, a HIV-1 reverse transcriptase inhibitor, and its 6-hydroxy metabolite in human plasma by column-switching high-performance liquid chromatography with fluorescence detection.: J Chromatogr A. 1996 Apr 5;729(1-2):211-7. Unique Identifier : AIDSLINE MED/96216792; Woolf EJ; Matuszewski B; Merck Research Laboratories, Department of Drug Metabolism, West; Point, PA 19486, USA.; A method for the determination of L-702,007, a human immunodeficiency virus type 1 reverse transcriptase inhibitor, and its 6-hydroxy metabolite in human plasma is described. Plasma samples are extracted using phenyl solid-phase extraction columns. The extract is analyzed by HPLC using a column-switching system to rem
Determination of a HIV protease inhibitor (DMP 450) in animal and human plasma by solid-phase extraction and high-performance liquid chromatography.: J Chromatogr B Biomed Appl. 1996 Apr 12;678(2):303-8. Unique Identifier : AIDSLINE MED/96346984; Grubb MF; Robinson CA; White SJ; Krauthauser CL; Shum L; Drug Metabolism and Pharmacokinetics Section, DuPont Merck; Pharmaceutical Company, Stine-Haskell Research Center, Newark, DE; 19714, USA.; Extraction of DMP 450 from plasma was performed with C2 solid-phase extraction columns, using 0.1 M ammonium acetate in 90% methanol to elute DMP 450. The extraction recovery over the range of 10 to 10 000 ng/ml averaged 81.0, 96.2, 77.4, 95.2 and 68.0% from rat, dog, monkey, chimpanzee (25-10 000 ng/ml) and human pla
The good, the bad and the ugly--can you refuse care?: Aust Nurs J. 1996 Oct;4(4):28-9. Unique Identifier : AIDSLINE MED/97082898; Napthine R
[Transference factor in moderate and severe atopic dermatitis]: Rev Alerg Mex. 1996 Sep-Oct;43(5):116-23. Unique Identifier : AIDSLINE MED/97122745; Navarro Cruz D; Serrano Miranda E; Orea M; Estrada Parra S; Teran Ortiz L; Gomez Vera J; Flores Sandoval G; Servicio de alergologia e inmunologia clinica, Hospital Regional Lic,; Adolfo Lopez Mateos, ISSSTE.; We did a prospective, comparative, experimental study with 30 patients with moderate to severe atopic dermatitis from the allergy section from September 1994 to March, 1995. The test laboratory examination was performed in all patients: complete blood cell count, immunoglobulins A, G, M and E determination, lymphocyte
Schiff base forming drugs: mechanisms of immune potentiation and therapeutic potential.: J Mol Med. 1996 Sep;74(9):497-504. Unique Identifier : AIDSLINE MED/97047134; Chen H; Rhodes J; Immunology Unit, Glaxo Wellcome Research and Development, Medicines; Research Centre, Stevenage, Hertfordshire, UK.; CD4 T-lymphocytes, which orchestrate immune responses, receive a cognitive signal when clonally distributed receptors are occupied by MHC class II bound peptides on antigen-presenting cells. The latter provide costimulatory or accessory signals through macromolecules such as B7.1 and B7.2 which interact with corecepto
Treatment of refractory diarrhoea in AIDS with acetorphan and octreotide: a randomized crossover study.: Eur J Gastroenterol Hepatol. 1996 May;8(5):485-9. Unique Identifier : AIDSLINE MED/96397994; Beaugerie L; Baumer P; Chaussade S; Berard H; Rozenbaum W; Pialoux G; Le Quintrec Y; Schwartz JC; Lecomte JM; Hopital Rothschild, Paris, France.; OBJECTIVE: To compare the efficacy and tolerance of acetorphan, an orally active enkephalinase inhibitor whose antidiarrhoeal properties derive from a purely antisecretory activity, to that of octreotide, a subcutaneously administered somatostatin analogue, in the treatment of refractory diarrhoea in AIDS patients. DE
Database of three-dimensional structures of HIV proteinases.: Nat Struct Biol. 1997 Jan;4(1):8. Unique Identifier : AIDSLINE MED/97143302; Vondrasek J; van Buskirk CP; Wlodawer A; Macromolecular Structure Laboratory, NCI-Frederick Cancer Research and; Development Center, ABL-Basic Research Program, Maryland 21702, USA.; vond@proxima.ncifcrf.gov
[Mechanisms of reduction of CD4 receptor expression on the surface of HIV-1 infected cells]: C R Acad Sci III. 1996 Aug;319(8):653-62. Unique Identifier : AIDSLINE MED/97106640; Geleziunas R; Morin N; Wainberg MA; Centre SIDA de l'Universite McGill, Montreal, Quebec, Canada.; Specific interactions between the cell surface CD4 receptor and the HIV-1 envelope glycoprotein gp120 are responsible for the entry of HIV into host cells. Following infection, a down-modulation of CD4 at the cell surface is commonly observed. This may render cells resistant to subsequent infection by HIV as well as o
Clinical characteristics and management responses in 85 HIV-infected patients with oral candidiasis.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996 Oct;82(4):402-7. Unique Identifier : AIDSLINE MED/97055490; Silverman S Jr; Gallo JW; McKnight ML; Mayer P; deSanz S; Tan MM; Division of Oral Medicine, School of Dentistry, University of; California, San Francisco, USA.; Eighty-five consecutively seen HIV-positive persons with oral candidiasis were evaluated for clinical characteristics, staging of HIV disease, quantitation of candidal colony formation, and response to systemic antifungal treatment with Nizoral ketoconazole). Fifty-five had CD4 counts less than 200. There was an incon
Oral hairy leukoplakia in a patient with multiple myeloma.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996 Oct;82(4):408-10. Unique Identifier : AIDSLINE MED/97055491; Blomgren J; Back H; Clinic of Oral Medicine, Ostra University Hospital, Goteborg, Sweden.; The first case of oral hairy leukoplakia in an HIV-negative patient with multiple myeloma is reported. The patient is a 56-year old man who has had monoclonal gammopathy of undetermined significance since 1986 and has been treated for a symptomatic multiple myeloma since 1993. The clinical and histopathologic findings
Alcohol consumption, brothel attendance, and condom use: normative expectations among Thai military conscripts.: Med Anthropol Q. 1996 Sep;10(3):402-23. Unique Identifier : AIDSLINE MED/97026848; MacQueen KM; Nopkesorn T; Sweat MD; Sawaengdee Y; Mastro TD; Weniger BG; Somdej Pranaresuan Maharaj Hospital, Phitsanuloke, Thailand.; This article investigates the relationship between alcohol consumption and inconsistent condom use with brothel-based commercial sex workers among Thai military conscripts in Northern Thailand . Data from 10 focus groups indicate that alcohol consumption (1) is consciously used by
[The tasks of public health organs concerning the prevention of infectious diseases]: Lik Sprava. 1996 Jan-Feb;(1-2):166-72. Unique Identifier : AIDSLINE MED/97085130; Mariievs'kyi VF
AIDS and Leishmania infantum. New approaches for a new epidemiological problem.: Clin Dermatol. 1996 Sep-Oct;14(5):541-6. Unique Identifier : AIDSLINE MED/97044262; Alvar J; Gutierrez-Solar B; Pachon I; Calbacho E; Ramirez M; Valles R; Guillen JL; Canavate C; Amela C; Reference Laboratory of Leishmaniasis, Centro Nacional de; Microbiologia, Instituto de Salud Carlos III, Madrid, Spain.
Overexpression of DNA polymerase beta sensitizes mammalian cells to 2',3'-deoxycytidine and 3'-azido-3'-deoxythymidine.: Cancer Res. 1997 Jan 1;57(1):110-6. Unique Identifier : AIDSLINE MED/97141792; Bouayadi K; Hoffmann JS; Fons P; Tiraby M; Reynes JP; Cazaux C; Laboratoire de Microbiologie et de Genetique, Universite Paul; Sabatier, Toulouse, France.; Mammalian DNA polymerase beta is a DNA repair enzyme expressed constitutively at a low level. In vitro, purified DNA polymerase Pol) beta incorporates the nucleotide analogues 2 -3 deoxycytidine ( ddC )-triphosphate and 3 -azido-3 -deoxythymidine
Identification of naturally processed human ovarian peptides recognized by tumor-associated CD8+ cytotoxic T lymphocytes.: Cancer Res. 1997 Jan 1;57(1):87-93. Unique Identifier : AIDSLINE MED/97141788; Fisk B; Anderson BW; Gravitt KR; O'Brian CA; Kudelka AP; Murray JL; Wharton JT; Ioannides CG; Department of Gynecologic Oncology, M. D. Anderson Cancer Center,; Houston, Texas 77030, USA.; Identification of naturally processed peptides recognized by tumorspecific CTLs may lead to epitope-specific tumor vaccines. Because these epitopes may be expressed differently on epithelial tumors and may differ in their ability to induce CTL in vivo, we have isolated the HLA-A2-peptide complexes by immunoaffinity fr
Sequential use of neural networks for survival prediction in AIDS.: Proc AMIA Annu Fall Symp. 1996;:170-4. Unique Identifier : AIDSLINE MED/97103278; Ohno-Machado L; Decision Systems Group, Brigham and Women's Hospital, Harvard Medical; School, Boston, MA 02115, USA. machado@dsg.harvard.edu; Prognostic assessment of patients is a key part of medical care. Although neural networks can be used to model survival, their accuracy has been limited for a variety of factors, including (1) the lack of data balance in certain intervals and (2) the lack of representation of temporal dependencies in the network archi
Trimethoprim-sulfamethoxazole: hyperkalemia is an important complication regardless of dose.: Clin Nephrol. 1996 Sep;46(3):187-92. Unique Identifier : AIDSLINE MED/97034198; Perazella MA; Mahnensmith RL; Department of Medicine, Yale University School of Medicine, New Haven,; CT 06520-8029, USA.; Trimethoprim-sulfamethoxazole is a frequently prescribed antibiotic with a wide spectrum of antimicrobial activity. As a result of the increasing number of AIDS patients requiring therapy for Pneumocystis carinii pneumonia, high dose trimethoprim-sulfamethoxazole use had dramatically increased. A previously unreported
Trimethoprim-sulfamethoxazole and hypouricemia.: Clin Nephrol. 1996 Sep;46(3):193-8. Unique Identifier : AIDSLINE MED/97034199; Chertow GM; Seifter JL; Christiansen CL; O'Donnell WJ; Renal Division, Brigham and Women's Hospital, Boston, MA 02115, USA.; BACKGROUND: Hypouricemia has been reported in a substantial fraction of patients with AIDS and attributed to an HIV-related renal urate transport defect. We tested the alternative hypothesis that hypouricemia was associated with the administration of high-dose trimethoprim-sulfamethoxazole TMP-SMX). METHODS: Sociodemo
Adrenal insufficiency, recurrent bacteremia, and disseminated abscesses caused by Nocardia asteroides in a patient with acquired immunodeficiency syndrome.: Diagn Microbiol Infect Dis. 1996 Jan;24(1):47-51. Unique Identifier : AIDSLINE MED/97142742; Arabi Y; Fairfax MR; Szuba MJ; Crane L; Schuman P; Department of Medicine, Wayne State University School of Medicine,; Detroit, Michigan, USA.; Nocardia asteroides is an opportunistic pathogen of increasing incidence in human immunodeficiency virus (HIV)-infected persons. The lungs are the most common site of infection, followed by the brain; involvement of other extrapulmonary sites is less common. We describe a patient with acquired immunodeficiency syndrom
Presumed bilateral herpes zoster ophthalmicus in an AIDS patient: a case report.: Cornea. 1996 Nov;15(6):633-4. Unique Identifier : AIDSLINE MED/97054988; Yau TH; Butrus SI; Department of Ophthalmology, Washington Hospital Center, DC, USA.; A 31-year-old man with the acquired immunodeficiency syndrome presented with herpes zoster ophthalmicus on the right. Five days after he began treatment for the zoster pseudodendrites and skin lesions, he developed superficial punctate keratitis, uveitis, and crusting skin lesions in the left eye. After treatment, the
Hepatic and pulmonary biopsy by mini-thoracotomy and transdiaphragmatic access.: Chest. 1996 Dec;110(6):1384-6. Unique Identifier : AIDSLINE MED/97143038; Fernandez A; Vip DE; Strabelli TM; Bammann RH; Vargas FS; Jatene FB; Division of Thoracic Surgery, Hospital das Clinicas University of Sao; Paulo Medical School, Brazil.; Frequently, immunodeficient patients have more than one organ or system affected by opportunistic infection or neoplasia, requiring quick and precise diagnostic investigation. In some situations, different invasive diagnostic procedures may be necessary. Open lung biopsy is sometimes necessary to clarify the pulmonary
Fluconazole vs itraconazole-flucytosine association in the treatment of esophageal candidiasis in AIDS patients. A double-blind, multicenter placebo-controlled study. The Candida Esophagitis Multicenter Italian Study (CEMIS) Group.: Chest. 1996 Dec;110(6):1507-14. Unique Identifier : AIDSLINE MED/97143058; Barbaro G; Barbarini G; Di Lorenzo G; Department of Emergency Medicine, University La Sapienza, Rome, Italy.; STUDY OBJECTIVE: To assess the role and the therapeutic efficacy of fluconazole and itraconazole-flucytosine association compared with placebo, in the treatment of endoscopically diagnosed esophageal candidiasis in a selected population of AIDS patients. DESIGN: Double-blind, placebo-controlled study. SETTING: Univers
Oxidant-protease interaction in the lung. Prospects for antioxidant therapy.: Chest. 1996 Dec;110(6 Suppl):267S-272S. Unique Identifier : AIDSLINE MED/97143152; Buhl R; Meyer A; Vogelmeier C; Medizinische Klinik II, Zentrum der Inneren Medizin,; Johann-Wolfgang-Goethe-Universitat, Frankfurt, Germany.; In inflammatory lung disorders, oxidants and proteases complement each other in their potential to destroy lung parenchyma. It is therefore rational to combine therapeutic strategies aimed at augmenting the antiproteolytic defenses of the lung in diseases such as emphysema with antioxidant strategies. In the healthy l
Comparison of itraconazole and ketoconazole in HIV-positive patients with oropharyngeal or esophageal candidiasis.Human Immunodeficiency Virus Itraconazole Ketoconazole Project Group.: Chemotherapy. 1996 Sep-Oct;42(5):374-83. Unique Identifier : AIDSLINE MED/97028965; de Repentigny L; Ratelle J; Department of Microbiology and Immunology, Faculty of Medicine,; University of Montreal, Que., Canada.; The efficacy of oral itraconazole and ketoconazole in the treatment of oropharyngeal and/or esophageal candidiasis, and the rate of post-treatment relapse, were compared in a multicenter, prospective, double-blind, double-dummy, randomized, parallel-group trial. A total of 143 adult HIV-positive patients with orophary
How many gated lymphocytes are needed for accurate assessment of T-subset percentages by flow cytometry?: Cytometry. 1996 Sep 15;26(3):223-6. Unique Identifier : AIDSLINE MED/97044324; Lape'-Nixon ML; Prince HE; MRL Reference Laboratory, Cypress, California 90630, USA.; Current regulatory agencies specify the use of 2,500 gated lymphocytes for accurate lymphocyte immunophenotyping by flow cytometry. However, acquisition of 2,500 gated lymphocytes is often technically infeasible when testing whole blood from lymphopenic patients. Our laboratory thus compared CD3, CD4, and CD8 percenta
Reference intervals of CD3, CD4, CD8, CD4/CD8, and absolute CD4 values in Asian and Non-Asian populations.: Cytometry. 1996 Sep 15;26(3):231-2. Unique Identifier : AIDSLINE MED/97044326; Howard RR; Fasano CS; Frey L; Miller CH; Department of Pathology, University of California Medical Center,; Davis at Sacramento, USA.; A study to determine reference intervals in normal Asian and non-Asian populations for CD3 (T cells), CD4 (T helper/inducer cells), CD8 (T suppressor/cytotoxic cells), and for the CD4/CD8 ratio and absolute CD4 lymphocyte count was performed. Coulter Clone/Cytostat reagents were used. The samples were lysed using the
Ritonavir.: Drugs. 1996 Oct;52(4):541-6; discussion 547-8. Unique Identifier : AIDSLINE MED/97046545; Lea AP; Faulds D; Adis International Limited, Auckland, New Zealand.; Ritonavir is a protease inhibitor with an HIV-1 resistance profile similar to that of indinavir , but different from that of saquinavir. Ritonavir has good oral bioavailability, and ma
Endoscopic diagnosis of a duodenocolic fistula due to a non-Hodgkin's lymphoma in a patient with AIDS.: Endoscopy. 1996 Aug;28(6):528-9. Unique Identifier : AIDSLINE MED/97041378; Becheur H; Piketty C; Bloch F; Levoir D; Aubertin JM; Bouillot JL; Petite JP; Dept. of Hepatogastroenterology, Broussais Hospital, Paris, France.
Biosynthesis and N-glycosylation of human interferon-gamma. Asn25 and Asn97 differ markedly in how efficiently they are glycosylated and in their oligosaccharide composition.: Eur J Biochem. 1996 Dec 1;242(2):191-200. Unique Identifier : AIDSLINE MED/97129092; Sareneva T; Mortz E; Tolo H; Roepstorff P; Julkunen I; Department of Virology, National Public Health Institute, Helsinki,; Finland.; Interferon-gamma (IFN-gamma) is a secretory glycoprotein produced by T cells in response to antigenic or mitogenic stimuli. We studied the kinetics of the synthesis, N-glycosylation, and secretion of IFN-gamma in human CD8+ T lymphocytes stimulated via T-cell receptor. Highly elevated IFN-gamma mRNA levels were found
Predictive value of HIV-1 RNA detection in plasma by branched DNA assay during long-term zidovudine therapy.: Eur J Clin Microbiol Infect Dis. 1996 Aug;15(8):639-45. Unique Identifier : AIDSLINE MED/97049843; Cotte L; Trabaud MA; Rougier P; Bailly F; Chapuis F; Trepo C; Service d'Hepatogastroenterologie et de SIDA, Hotel-Dieu, Lyon,; France.; The predictive value of human immunodeficiency virus type 1 HIV-1) RNA detection in plasma using branched DNA assay was studied in a subgroup of 36 asymptomatic HIV-1-infected patients enrolled in a multicenter, double-blind, randomized study. Patients were randomized to receive either zidovudine (
Acute myocarditis mimicking myocardial infarction in an HIV infected patient [letter]: Eur Heart J. 1996 Sep;17(9):1449. Unique Identifier : AIDSLINE MED/97034378; Monsuez JJ; Ferchal F; Evans J; Lachurie ML; Passeron J
Vertical human immunodeficiency virus-1 infection: involvement of the central nervous system and treatment.: Eur J Pediatr. 1996 Oct;155(10):839-50. Unique Identifier : AIDSLINE MED/97046631; Exhenry C; Nadal D; Infectious Diseases Unit, University Children's Hospital of Zurich,; Switzerland.; Involvement of the central nervous system (CNS) contributes substantially to morbidity and mortality of vertical infection with the human immunodeficiency virus (HIV)-1. The clinical spectrum ranges from minor developmental disabilities to severe and progressive encephalopathy. Progression of the disease varies consid
Identification and isolation of a 155-kDa protein with neuropathy target esterase activity.: Fundam Appl Toxicol. 1996 Mar;30(1):23-30. Unique Identifier : AIDSLINE MED/96436320; Mackay CE; Hammock BD; Wilson BW; Department of Avian Science and Environmental Toxicology, University; of California, Davis 95616, USA.; A method is presented for the isolation of a 155-kDa protein that possesses phenyl valerate hydrolysis activity in the presence of paraoxon but is inhibited by mipafox; the functional definition of neuropathy target esterase (neurotoxic esterase; NTE). Microsomes, isolated from 18-day-old chicken embryos were treated
Endoscopic appearance of Mycobacterium genavense: case report and review of the literature [see comments]: Gastrointest Endosc. 1996 Sep;44(3):331-3. Unique Identifier : AIDSLINE MED/97039810; Koehler M; Chak A; Setrakian S; Sivak MV Jr; Division of Gastroenterology, Case Western Reserve University,; University Hospitals of Cleveland, OH 44106, USA.
Biliary fistula in a patient with HIV cholangiopathy.: Gastrointest Endosc. 1996 Sep;44(3):345-8. Unique Identifier : AIDSLINE MED/97039815; Cacciarelli AG; Freiman HJ; Anderson JD; Robilotti JG; St. Vincent's Hospital and Medical Center, Department of Medicine, New; York, NY 10011, USA.
Activation of the HIV long terminal repeat and viral production by H2O2-vanadate.: Free Radic Biol Med. 1996;20(6):813-20. Unique Identifier : AIDSLINE MED/96285844; Kazazi F; Koehler JK; Klebanoff SJ; Department of Medicine, University of Washington School of Medicine,; Seattle, USA.; The long terminal repeat (LTR) of human immunodeficiency virus type 1 (HIV-1) contains sequences required for the initiation of gene transcription. Among the substances known to activate the HIV-1 LTR is hydrogen peroxide (H2O2). We report here that H2O2-induced activation of the LTR in the macrophage cell line THP-1
[Tracking down natural resistance to HIV. Defective cellular receptor prevents entrance of virus into the cell]: Fortschr Med. 1996 Oct 20;114(29):12, 14. Unique Identifier : AIDSLINE MED/97087760; Hobom B
A case of hepatocellular carcinoma in HIV-infected patient.: Hepatogastroenterology. 1996 Jul-Aug;43(10):1067-72. Unique Identifier : AIDSLINE MED/97038760; Tanaka T; Imamura A; Masuda G; Ajisawa A; Negishi M; Tanaka S; Koike M; Hattori N; Liver Unit, Tokyo Metropolitan Komagome Hospital, Japan.; Persistent human immunodeficiency virus (HIV) infection induces an immuno-suppressive state and therefore malignant tumors are a very common complication. Hepatocellular carcinoma is very rare, however, because it is associated with chronic liver disease by the persistent infection of hepatitis B or C virus (HBV or HC
Cytomegalovirus enteritis causing massive bleeding in a patient with AIDS.: Hepatogastroenterology. 1996 Jul-Aug;43(10):987-91. Unique Identifier : AIDSLINE MED/97038744; Lai IR; Chen KM; Shun CT; Chen MY; Department of Surgery, National Taiwan University Hospital, Taipei.; An emergency operation was performed on a 58 year-old heterosexual male patient for massive lower gastrointestinal bleeding, which was caused by cytomegalovirus ( CMV ) related ulceration at the terminal ileum. Pre-operative en
Lamivudine is effective in suppressing hepatitis B virus DNA in Chinese hepatitis B surface antigen carriers: a placebo-controlled trial.: Hepatology. 1997 Jan;25(1):241-4. Unique Identifier : AIDSLINE MED/97138272; Lai CL; Ching CK; Tung AK; Li E; Young J; Hill A; Wong BC; Dent J; Wu PC; Department of Medicine, University of Hong Kong.; Lamivudine is a novel 2 ,3 -dideoxy cytosine analogue that has potent inhibitory effects on hepatitis B virus replication in vitro and in vivo. We performed a single-blind, placebo-controlled study to assess its effectiveness and safety in Chinese hep
Immune deviation--the third dimension of nondeletional T cell tolerance.: Immunol Rev. 1996 Feb;149:175-94. Unique Identifier : AIDSLINE MED/96402166; Rocken M; Shevach EM; Department of Dermatology, Ludwig-Maximilians-University Munchen,; Germany.
Mechanisms of peripheral tolerance and suppression induced by monoclonal antibodies to CD4 and CD8.: Immunol Rev. 1996 Feb;149:5-33. Unique Identifier : AIDSLINE MED/96402159; Cobbold SP; Adams E; Marshall SE; Davies JD; Waldmann H; Therapeutic Immunology Group, Sir William Dunn School of Pathology,; Oxford, UK.; Over the last five years it has become increasingly clear that the peripheral immune system can maintain tolerance to both self and non-self antigens through a variety of mechanisms. Although clonal deletion may play an important part in limiting rapidly expanding responses, there are many examples where antigen react
Similar abnormalities of idiotype and immunoglobulin light chain expression and of cell-mediated cytotoxicity in HIV-infected humans and simian immunodeficiency virus (SIV)-infected rhesus macaques.: Immunol Cell Biol. 1996 Feb;74(1):38-44. Unique Identifier : AIDSLINE MED/97088744; Grant MD; Whaley MD; Mayne A; Hoffmann GW; Ansari AA; Department of Microbiology and Immunology, University of British; Columbia, Vancouver, Canada.; The pathogenesis of AIDS in simian immunodeficiency virus SIV)-infected rhesus macaques models the pathogenesis of human AIDS. We investigated whether certain immunological abnormalities associated with HIV infection and implicated in disease progression also occur in SIV infection. We observed striking parallels betw
Kaposi's sarcoma and non-Hodgkin's lymphoma following the diagnosis of AIDS. Multistate AIDS/Cancer Match Study Group [published erratum appears in Int J Cancer 1997 Mar 17;70(6):727]: Int J Cancer. 1996 Dec 11;68(6):754-8. Unique Identifier : AIDSLINE MED/97134619; Biggar RJ; Rosenberg PS; Cote T; Viral Epidemiology, National Cancer Institute, Bethesda, MD, USA.; biggarb@EPNDCE.NCI.NIH.GOV; We linked records of 83,434 AIDS cases reported to AIDS registries through 1990 to cancer registry records during times when overlap in registration existed. Of 8,496 Kaposi s-sarcoma KS) cases meeting enrollment criteria, 1,045 occurred semesters 2 through 4 (6 through 23 months) after another AIDS-defining illness.
Microsatellite instability in B-cell lymphoma originating from Bloom syndrome.: Int J Cancer. 1996 Dec 20;69(6):480-3. Unique Identifier : AIDSLINE MED/97134691; Kaneko H; Inoue R; Yamada Y; Sukegawa K; Fukao T; Tashita H; Teramoto T; Kasahara K; Takami T; Kondo N; Department of Pediatrics, Gifu University School of Medicine,; Tsukasa-mati, Japan. hideo@cc.gifu-u.ac.jp; Bloom syndrome (BS) is a rare autosomal recessive genetic disorder characterized by lupus-like erythematous telangiectasias of the face, sun sensitivity, stunted growth infertility and immunodeficiency. In addition, BS patients are highly predisposed to cancers. Although recently the causative gene of BS (BLM) was ide
Dendritic epidermal T-cell involvement in induction of CD8+ T cell-mediated immunity against an ultraviolet radiation-induced skin tumor.: Int J Cancer. 1997 Jan 6;70(1):98-105. Unique Identifier : AIDSLINE MED/97138071; Cavanagh LL; Barnetson RS; Basten A; Halliday GM; Department of Medicine (Dermatology), University of Sydney at Royal; Prince Alfred Hospital, Camperdown, Australia. loisc@gpo.pa.uq.edu.au; Murine epidermis contains 2 distinct cell populations which contribute to the skin immune system, Langerhans cells (LC), and dendritic epidermal T cells (DETC). LCs are important in the induction of immunity against a wide range of antigens; however, the function of DETC is unclear. To investigate the roles of these e
Sequential cellular and humoral responses in the abomasal mucosa and blood of Romney sheep dosed with Trichostrongylus axei.: Int J Parasitol. 1996 Jul;26(7):765-73. Unique Identifier : AIDSLINE MED/97050040; Pfeffer A; Douch PG; Shaw RJ; Gatehouse TK; Rabel B; Green RS; Shirer CL; Jonas WE; Bisset S; Wallaceville Animal Research Centre, AgResearch, Upper Hutt, New; Zealand. Pfeffera@agresearch.cri.nz; Abomasal cannulae were surgically placed in 7 2-year-old New Zealand Romney sheep which had been maintained parasite-free from birth. Four of these sheep were randomly selected and dosed orally with 10,000 infective Trichostrongylus axei larvae per week for 8 weeks, while the r
Growth of Lucilia cuprina larvae following treatment of sheep divergently selected for fleece rot and fly strike with monoclonal antibodies to T lymphocyte subsets and interferon gamma.: Int J Parasitol. 1996 Jul;26(7):775-82. Unique Identifier : AIDSLINE MED/97050041; Colditz IG; Eisemann CH; Tellam RL; McClure SJ; Mortimer SI; Husband AJ; CSIRO Division of Animal Production, Pastoral Research Laboratory,; Armidale, NSW 2350, Australia. icolditz@chiswick.anprod.csiro.au; Intensive lymphocytic infiltration of the underlying dermis occurs during cutaneous myiasis caused by larvae of the blow fly, Lucilia cuprina. To determine the effect of this infiltrate on larval growth, monoclonal antibodies (mAb) to CD4, CD8 or WC1 lymphocyte subset determinants were injected intravenously before an
Nursing: sustaining the circle of life in HIV/AIDS prevention and care [news]: Int Nurs Rev. 1996 Sep-Oct;43(5):132. Unique Identifier : AIDSLINE MED/97050109
Natasha's story: seeking an FIV diagnosis [news]: J Am Vet Med Assoc. 1996 Nov 15;209(10):1680. Unique Identifier : AIDSLINE MED/97079282; Kahler SC
FIV diagnosis not an imminent death sentence [news]: J Am Vet Med Assoc. 1996 Dec 1;209(11):1832. Unique Identifier : AIDSLINE MED/97100229; Kahler SC
Human immunodeficiency virus. Mutations in the viral protease that confer resistance to saquinavir increase the dissociation rate constant of the protease-saquinavir complex.: J Biol Chem. 1996 Dec 27;271(52):33231-5. Unique Identifier : AIDSLINE MED/97125958; Maschera B; Darby G; Palu G; Wright LL; Tisdale M; Myers R; Blair ED; Furfine ES; Department of Virology, Glaxo Wellcome, Stevenage SG1 2NY, United; Kingdom.; Mutations in the human immunodeficiency virus (HIV) protease L90M, G48V, and L90M/G48V) arise when HIV is passaged in the presence of the HIV protease inhibitor saquinavir. These mutations yield a virus with less sensitivity to the drug (L90M > G48V >> L90M/G48V). L90M, G48V, and L90M/G48V proteases have 1/20, 1/160,
Restoration of both structure and function to a defective poly(A) site by in vitro selection.: J Biol Chem. 1996 Dec 27;271(52):33654-63. Unique Identifier : AIDSLINE MED/97126013; Graveley BR; Fleming ES; Gilmartin GM; Department of Microbiology and Molecular Genetics, Markey Center for; Molecular Genetics, Stafford Hall, University of Vermont, Burlington,; Vermont 05405, USA. ggilmart@moose.uvm.edu; Efficient cleavage and polyadenylation at the human immunodeficiency virus type-1 (HIV-1) poly(A) site requires an upstream 3 -processing enhancer to overcome the suboptimal sequence context of the AAUAAA hexamer. The HIV-1 3 -processing enhancer functions to stabilize the association of the pre-mRNA with cleavage and
NCp7 activates HIV-1Lai RNA dimerization by converting a transient loop-loop complex into a stable dimer.: J Biol Chem. 1996 Dec 27;271(52):33686-92. Unique Identifier : AIDSLINE MED/97126017; Muriaux D; De Rocquigny H; Roques BP; Paoletti J; Unite de Biochimie, URA 147 CNRS, 39 rue Camille Desmoulins, Institut; Gustave Roussy, 94805 Villejuif, France.; Nucleocapsid protein 7 (NCp7), the human immunodeficiency virus type 1 (HIV-1) nucleocapsid protein, was shown to strongly potentiate the dimerization of the retroviral genomic RNA. This process involves the interaction of two retroviral RNA monomer subunits near their 5 -ends. A region located upstream from the splic
Leiomyoma of the hand in a child who has the human immunodeficiency virus.: J Bone Joint Surg Am. 1996 Dec;78(12):1904-6. Unique Identifier : AIDSLINE MED/97140178; Yang SS; Williams RJ; Bear BJ; McCormack RR; The New York Hospital-Cornell Medical Center, New York City, N.Y.,; USA.
Human T-cell lymphotropic virus type-I associated myelopathy complicated by optic neuritis.: Nippon Ika Daigaku Zasshi. 1996 Oct;63(5):414-8. Unique Identifier : AIDSLINE MED/97091415; Komaba Y; Kitamura S; Terashi A; Tamotsu M; Nakatani Y; Hara A; Second Department of Internal Medicine, Nippon Medical School, Tokyo,; Japan.; A 48-year-old Japanese woman from Kyushu was admitted to the Nippon Medical School First Hospital with complaints of numbness in both legs, gait disturbance, and urinary problems. On examination, her lower extremities were spastic with increased reflexes and positive Babinski sign. Sensation was absent below the T4 sp
Evaluation of an extended blood culture protocol to isolate fastidious organisms from patients with AIDS.: J Clin Microbiol. 1996 Oct;34(10):2444-7. Unique Identifier : AIDSLINE MED/97034841; Dougherty MJ; Spach DH; Larson AM; Hooton TM; Coyle MB; Department of Laboratory Medicine, Harborview Medical Center,; University of Washington, Seattle 98104, USA.; Recent reports of fastidious pathogens suggest the need for special blood cultures for immunocompromised patients. Blood cultures from 45 human immunodeficiency virus (HIV)-infected patients with unexplained fever (> or = 38.0 degrees C) and CD4 counts of
Diagnostic antigenemia tests for penicilliosis marneffei.: J Clin Microbiol. 1996 Oct;34(10):2503-5. Unique Identifier : AIDSLINE MED/97034853; Kaufman L; Standard PG; Jalbert M; Kantipong P; Limpakarnjanarat K; Mastro TD; Division of Bacterial and Mycotic Diseases, National Center for; Infectious Diseases, Centers for Disease Control and Prevention,; Atlanta, Georgia 30333, USA.; Disseminated penicilliosis marneffei is an emerging opportunistic mycosis seen in severely immunocompromised human immunodeficiency virus (HIV)-infected patients and is caused by the dimorphic fungus Penicillium marneffei. Early diagnosis and treatment improve clinical outcome. Proper diagnosis is complicated by nonsp
Prevalence of human herpesvirus 8 DNA sequences in several patient populations.: J Clin Microbiol. 1996 Oct;34(10):2635-8. Unique Identifier : AIDSLINE MED/97034886; Marchioli CC; Love JL; Abbott LZ; Huang YQ; Remick SC; Surtento-Reodica N; Hutchison RE; Mildvan D; Friedman-Kien AE; Poiesz BJ; Department of Internal Medicine, SUNY Health Science Center, Syracuse; 13210, USA.; We have undertaken a large-scale study of various tissues from normal controls and patients with Kaposi s sarcoma (KS) or other malignancies, both with and without human immunodeficiency virus infection, to determine the prevalence of human herpesvirus 8 HHV-8) DNA. A total of 566 specimens were analyzed by PCR for th
Accelerated neutrophil apoptosis in the acquired immunodeficiency syndrome.: J Clin Invest. 1996 Dec 15;98(12):2714-9. Unique Identifier : AIDSLINE MED/97136515; Pitrak DL; Tsai HC; Mullane KM; Sutton SH; Stevens P; Department of Medicine, University of Illinois College of Medicine at; Chicago, West Side VA Medical Center, 60612, USA.; Neutrophil (PMNL) function defects occur as a consequence of HIV infection. This study examined PMNL apoptosis in patients with the acquired immunodeficiency syndrome (AIDS) to determine if accelerated apoptosis contributes to impaired function. PMNL were isolated from 10 HIV-infected patients with CD4+ lymphocyte cou
HLA-B27 heavy chains contribute to spontaneous inflammatory disease in B27/human beta2-microglobulin (beta2m) double transgenic mice with disrupted mouse beta2m.: J Clin Invest. 1996 Dec 15;98(12):2746-55. Unique Identifier : AIDSLINE MED/97136519; Khare SD; Hansen J; Luthra HS; David CS; Department of Immunology, Mayo Clinic and Medical School, Rochester,; Minnesota 55905, USA.; MHC class I allele, HLA-B27, is strongly associated with a group of human diseases called spondyloarthropathies. Some of these diseases have an onset after an enteric or genitourinary infection. In the present study, we describe spontaneous disease in HLA-B27 transgenic mice where endogenous beta2-microglobulin beta2m
Long-lived and transferable tumor immunity in mice after targeted interleukin-2 therapy.: J Clin Invest. 1996 Dec 15;98(12):2801-4. Unique Identifier : AIDSLINE MED/97136526; Becker JC; Varki N; Gillies SD; Furukawa K; Reisfeld RA; The Scripps Research Institute, Department of Immunology, La Jolla,; California 92037, USA.; A major goal of tumor immunotherapy is the induction of tumor-specific T cell responses that are effective in eradicating disseminated tumor, as well as mounting a persistent tumor-protective immunity. We demonstrate here that a genetically engineered fusion protein consisting of human/mouse chimeric anti-ganglioside
Iron deficiency, giardiasis and HIV disease [editorial; comment]: J Am Coll Nutr. 1996 Oct;15(5):421. Unique Identifier : AIDSLINE MED/97047246; Filer LJ Jr
Down-regulation of IL-12, not a shift from a T helper-1 to a T helper-2 phenotype, is responsible for impaired IFN-gamma production in mammary tumor-bearing mice.: J Immunol. 1997 Jan 1;158(1):280-6. Unique Identifier : AIDSLINE MED/97131699; Handel-Fernandez ME; Cheng X; Herbert LM; Lopez DM; Department of Microbiology and Immunology, University of Miami School; of Medicine, FL 33101, USA.; Altered cytokine production has been implicated in the down-regulation of cell-mediated immunity in mice bearing large mammary tumors. In several diseases, an imbalance between helper T lymphocytes Th1 and Th2 and their cytokines has been suggested as a contributing factor. In this study, although IFN-gamma from splen
Immune CD8+ T lymphocytes lyse Listeria monocytogenes-infected hepatocytes by a classical MHC class I-restricted mechanism.: J Immunol. 1997 Jan 1;158(1):287-93. Unique Identifier : AIDSLINE MED/97131700; Jiang X; Gregory SH; Wing EJ; Department of Medicine, University of Pittsburgh Medical Center, PA; 15213, USA.; Hepatocytes constitute the principal site of listerial replication in the livers of mice infected i.v. CD8+ T lymphocytes play a predominant role in the host defenses to Listeria monocytogenes. In vitro experiments by others undertaken to delineate the functions of CD8+ T lymphocytes have focused primarily on their in
Blockade of CD40 ligand-CD40 interaction impairs CD4+ T cell-mediated alloreactivity by inhibiting mature donor T cell expansion and function after bone marrow transplantation.: J Immunol. 1997 Jan 1;158(1):29-39. Unique Identifier : AIDSLINE MED/97131671; Blazar BR; Taylor PA; Panoskaltsis-Mortari A; Buhlman J; Xu J; Flavell RA; Korngold R; Noelle R; Vallera DA; Department of Pediatrics, University of Minnesota, Minneapolis 55455,; USA.; Alloreactive T cells require costimulatory signals via CD40 ligand (CD40L). The tissue-destructive properties of allogeneic CD4+ but not CD8+ T cells were inhibited by anti-CD40L mAb. Fewer CD4+ thoracic duct lymphocytes (TDL) were obtained in mAb-treated recipients. Kinetic studies revealed that CD4+ T cell expansion
Antigen-driven but not lipopolysaccharide-driven IL-12 production in macrophages requires triggering of CD40.: J Immunol. 1997 Jan 1;158(1):359-66. Unique Identifier : AIDSLINE MED/97131710; DeKruyff RH; Gieni RS; Umetsu DT; Division of Immunology and Transplantation Biology, Department of; Pediatrics, Stanford University, CA 94305, USA.; We demonstrated that two distinct pathways exist for the induction of IL-12 in APC. The first pathway for IL-12 production occurred during responses to T cell-dependent Ags such as OVA and required triggering of CD40 molecules on the APC. IL-12 production in this T cell-dependent system increased in direct proportion
Priming with IFN-gamma restores deficient IL-12 production by peripheral blood mononuclear cells from HIV-seropositive donors.: J Immunol. 1997 Jan 1;158(1):459-63. Unique Identifier : AIDSLINE MED/97131722; Harrison TS; Levitz SM; Evans Memorial Department of Clinical Research, Boston University; Medical Center Hospital, MA 02118, USA.; Production of IL-12 is deficient in PBMC from HIV-infected individuals. Because of recent studies demonstrating that IFN-gamma priming increases the production of IL-12 in normal PBMC, we examined the role of IFN-gamma in the production of IL-12 in PBMC from HIV-seropositive donors. In response to Staphylococcus aureu
Evidence for B cell-mediated activation of V delta 1+ T lymphocytes during progression of HIV infection.: J Immunol. 1997 Jan 1;158(1):464-74. Unique Identifier : AIDSLINE MED/97131723; Hyjek EM; Bartkowiak J; Drozdz R; Wasik TJ; Jasinski M; Kaneko Y; Lischner HW; Kozbor D; Department of Microbiology and Immunology, Kimmel Cancer Center,; Thomas Jefferson University, Philadelphia, PA 19107, USA.; Progression of HIV-induced immunodeficiency is associated with both B cell activation and an increased proportion of Vdelta1+ T cells in PBL. To examine whether the peripheral expansion of Vdelta1+ cells is driven by activated B cells, we isolated CD19+ PBL from HIV+ individuals at different stages of infection and us
Chemotaxis and IL-8 receptor expression in B cells from normal and HIV-infected subjects.: J Immunol. 1997 Jan 1;158(1):475-84. Unique Identifier : AIDSLINE MED/97131724; Jinquan T; Moller B; Storgaard M; Mukaida N; Bonde J; Grunnet N; Black FT; Larsen CG; Matsushima K; Thestrup-Pedersen K; Department of Dermatology, University Hospital, Aarhus University,; Denmark.; To date, the activities of the alpha chemokines for human peripheral B cells from normal subjects (N-B cells) or from HIV-infected subjects (HIV-B cells) are not well established. No report on the IL-8R expression on N-B cells and HIV-B cells has been seen. We report in this work that the alpha chemokines IL-8 and gro
Patients with multidrug-resistant tuberculosis with low CD4+ T cell counts have impaired Th1 responses.: J Immunol. 1997 Jan 1;158(1):492-500. Unique Identifier : AIDSLINE MED/97131726; McDyer JF; Hackley MN; Walsh TE; Cook JL; Seder RA; Laboratory of Clinical Investigation, National Institute of Allergy; and Infectious Diseases, Bethesda, MD 20892, USA.; Multidrug-resistant tuberculosis (MDRTB) has emerged as a challenging clinical problem in both HIV-infected and -uninfected individuals. In this study, immune responses from HIV-negative patients with MDRTB were compared with those of healthy purified protein derivative (PPD)-positive and PPD-negative individuals. The
IL-16 represses HIV-1 promoter activity.: J Immunol. 1997 Jan 1;158(1):5-8. Unique Identifier : AIDSLINE MED/97131667; Maciaszek JW; Parada NA; Cruikshank WW; Center DM; Kornfeld H; Viglianti GA; The Program in Virology and Immunology, University of Massachusetts; Medical Center, Worcester 01605, USA.; IL-16 is produced by CD8+ lymphocytes and has been reported to inhibit HIV-1 and SIV replication in infected PBMCs. CD4 serves as a receptor for the secreted form of IL-16, and IL-16 binding to CD4 induces signal transduction, which affects the activation state of the cell. We hypothesized, therefore, that the effect
The state of maturation of monocytes into macrophages determines the effects of IL-4 and IL-13 on HIV replication.: J Immunol. 1997 Jan 1;158(1):501-11. Unique Identifier : AIDSLINE MED/97131727; Naif HM; Li S; Ho-Shon M; Mathijs JM; Williamson P; Cunningham AL; Westmead Institutes of Health Research, National Centre for HIV; Virology Reearch, University of Sydney, Australia.; The molecular mechanisms of the effects of IL-4 and IL-13 on HIV infection in human monocytes as they matured into monocyte-derived macrophages over 7 days were investigated using HIV-1(BaL), and low passage clinical strains. IL-4 and IL-13 up-regulated the expression of both genomic and spliced HIV mRNA in monocytes
Nuclear import of HIV-1 DNA in resting CD4+ T cells requires a cyclosporin A-sensitive pathway.: J Immunol. 1997 Jan 1;158(1):512-7. Unique Identifier : AIDSLINE MED/97131728; Sun Y; Pinchuk LM; Agy MB; Clark EA; Washington Regional Primate Research Center, University of Washington,; Seattle 98195, USA.; Using PCR to monitor early (LTR/LTR (long terminal repeat)) and late (LTR/gag) products of reverse transcription and the formation of HIV-1 LTR circles (indicating nuclear import), we explored the relationship between T cell activation signals and early events in the life cycle of HIV-1 infection. The combination of T
CD4 ligands inhibit the formation of multifunctional transduction complexes involved in T cell activation.: J Immunol. 1997 Jan 1;158(1):94-103. Unique Identifier : AIDSLINE MED/97131678; Jabado N; Pallier A; Le Deist F; Bernard F; Fischer A; Hivroz C; INSERM Unit 429, Necker-Enfants Malades Hospital, Paris, France.; Ligands binding to the CD4 molecule can inhibit TCR-mediated T cell activation. We have previously reported that transcription factors regulating the expression of the IL-2 gene, NF-AT, NF-kappaB, and AP-1, are targets of this inhibitory effect in an in vitro model usi
First report of Cryptococcus albidus septicaemia in an HIV patient.: J Infect. 1996 Sep;33(2):139-40. Unique Identifier : AIDSLINE MED/97044935; Loison J; Bouchara JP; Gueho E; de Gentile L; Cimon B; Chennebault JM; Chabasse D
Alveolar macrophage activation in HIV infection.: J Infect. 1996 Sep;33(2):91-4. Unique Identifier : AIDSLINE MED/97044924; Evans MR; Wansbrough-Jones MH; Division of Infectious Diseases, St. George's Hospital Medical School,; London, U.K.; Alveolar macrophage function is critical to the pulmonary immune response to infection. It is not known whether alveolar macrophages from HIV-infected individuals function normally in vivo. We have measured neopterin concentration, a marker of macrophage activation, in induced sputum, serum and saliva samples from con
The association between hepatitis C virus genotype and human immunodeficiency virus disease progression in a cohort of hemophilic men [see comments]: J Infect Dis. 1997 Jan;175(1):164-8. Unique Identifier : AIDSLINE MED/97138186; Sabin CA; Telfer P; Phillips AN; Bhagani S; Lee CA; Haemophilia Centre, Department of Haematology, Royal Free Hospital and; School of Medicine, London, United Kingdom.; Patients coinfected with both hepatitis C virus (HCV) and the human immunodeficiency virus (HIV) have more rapid progression of HCV infection; however, little is known about the effect of coinfection with HCV on the progression of HIV disease. This study assessed the association between infection with different HCV ge
Maternal virus load during pregnancy and mother-to-child transmission of human immunodeficiency virus type 1: the French perinatal cohort studies. SEROGEST Cohort Group.: J Infect Dis. 1997 Jan;175(1):172-5. Unique Identifier : AIDSLINE MED/97138188; Mayaux MJ; Dussaix E; Isopet J; Rekacewicz C; Mandelbrot L; Ciraru-Vigneron N; Allemon MC; Chambrin V; Katlama C; Delfraissy JF; Puel J; SEROGEST Cohort and Unite 292 INSERM, Hopital Kremlin Bicetre, France.; Virus load in pregnancy and its relation to mother-to-child human immunodeficiency virus (HIV) transmission were studied prospectively. From 1989 to 1994, 320 HIV-infected women from 18 centers had plasma samples stored. Among women not receiving antiretroviral therapy, the polymerase chain reaction RNA level was 3.6
Drug sensitivity of human immunodeficiency virus type 1 isolates after ribavirin therapy.: J Infect Dis. 1997 Jan;175(1):176-8. Unique Identifier : AIDSLINE MED/97138189; Bernier R; Tremblay M; Tsoukas C; Bergeron MG; Centre de Recherche en Infectiologie, Departement de Microbiologie,; Faculte de Medecine, Universite Laval, Ste-Foy, Montreal, Canada.; The antiviral agent ribavirin is effective against several virally induced diseases, and there is evidence that it might prove useful against human immunodeficiency virus type 1 (HIV-1) infection. Thus, there is interest in studying the resistance level of HIV-1 isolates to ribavirin following drug therapy. Low-passag
Cytomegalovirus gB genotype distribution differs in human immunodeficiency virus-infected patients and immunocompromised allograft recipients.: J Infect Dis. 1997 Jan;175(1):179-84. Unique Identifier : AIDSLINE MED/97138190; Rasmussen L; Hong C; Zipeto D; Morris S; Sherman D; Chou S; Miner R; Drew WL; Wolitz R; Dowling A; Warford A; Merigan TC; Center for AIDS Research, Division of Infectious Diseases and; Geographic Medicine, Stanford University School of Medicine, CA 94305,; USA. lucy.rasmussen@stanford.edu; Cytomegalovirus isolates can be grouped into 4 gB and 2 gH genotypes. gB genotypes were studied in patients infected with human immunodeficiency virus (HIV) and in allograft transplantation recipients. In allograft recipients, the distribution of gB 1, -2, -3, and -4 in leukocytes and urine, respectively, was 36%, 21%
Simian immunodeficiency virus-inoculated macaques acquire Mycobacterium avium from potable water during AIDS.: J Infect Dis. 1997 Jan;175(1):184-7. Unique Identifier : AIDSLINE MED/97138191; Mansfield KG; Lackner AA; New England Regional Primate Research Center, Harvard Medical School,; Southborough, Massachusetts 01772-9012, USA.; During the terminal stages of AIDS, Mycobacterium avium complex MAC) infection is the most common disseminated bacterial infection in rhesus macaques (Macaca mulatta) experimentally inoculated with the simian immunodeficiency virus (SIV). The source of mycobacterial infection in 15 SIV-inoculated rhesus macaques house
Polymorphisms within the human tumor necrosis factor-alpha promoter region in human immunodeficiency virus type 1-seropositive persons.: J Infect Dis. 1997 Jan;175(1):188-90. Unique Identifier : AIDSLINE MED/97138192; Brinkman BM; Keet IP; Miedema F; Verweij CL; Klein MR; Department of Rheumatology, University Hospital Leiden, Netherlands.; The question is addressed whether particular tumor necrosis factor-alpha (TNF-alpha) polymorphisms are associated with clinical course and outcome of human immunodeficiency virus type 1 (HIV-1) infection. The distribution of four TNF-alpha guanine G) to adenosine (A) transition polymorphisms at positions -376, 308, -2
Effect of Lactobacillus reuteri on intestinal resistance to Cryptosporidium parvum infection in a murine model of acquired immunodeficiency syndrome.: J Infect Dis. 1997 Jan;175(1):218-21. Unique Identifier : AIDSLINE MED/97138199; Alak JI; Wolf BW; Mdurvwa EG; Pimentel-Smith GE; Adeyemo O; Center For Biomedical Research and Department of Microbiology, School; of Veterinary Medicine, Tuskegee University, Alabama 36088, USA.; Efficacy of Lactobacillus reuteri as a probiotic for the control of Cryptosporidium parvum infection was evaluated in C57BL/6 female mice that were immunosuppressed by intraperitoneal inoculation with the LP-BM5 leukemia virus. Four months after inoculation, mice developed lymphadenopathy, splenomegaly, and susceptibi
Modulatory potential of iron chelation therapy on nitric oxide formation in cerebral malaria.: J Infect Dis. 1997 Jan;175(1):226-30. Unique Identifier : AIDSLINE MED/97138201; Weiss G; Thuma PE; Mabeza G; Werner ER; Herold M; Gordeuk VR; Department of Internal Medicine, University Hospital, University of; Innsbruck, Austria.; To determine whether iron chelation modulates nitric oxide (NO) formation and cell-mediated immune effector function in children with cerebral malaria, serum concentrations were measured of the stable end products of NO, nitrite and nitrate (NO2-/NO3-), interleukin (IL)-4, 6, and -10, and neopterin in 39 Zambian child
Appearance of autologous neutralizing antibody correlates with reduction in virus load and phenotype switch during primary infection with human immunodeficiency virus type 1 [letter; comment]: J Infect Dis. 1997 Jan;175(1):231-2. Unique Identifier : AIDSLINE MED/97138202; Lathey JL; Pratt RD; Spector SA
Cytokine pattern in relation to disease progression in human immunodeficiency virus-infected children.: J Infect Dis. 1997 Jan;175(1):47-56. Unique Identifier : AIDSLINE MED/97138169; Than S; Hu R; Oyaizu N; Romano J; Wang X; Sheikh S; Pahwa S; Department of Pediatrics, North Shore University Hospital-Cornell; University Medical College, Manhasset, New York 11030, USA.; Cytokine mRNA expression and stimulus-induced cytokines were examined in peripheral blood mononuclear cells in 62 human immunodeficiency virus (HIV)-infected children and uninfected controls. Compared with that in controls, constitutive mRNA expression in patients was increased for tumor necrosis factor TNF)-alpha, in
Genital shedding of human immunodeficiency virus type 1 DNA during pregnancy: association with immunosuppression, abnormal cervical or vaginal discharge, and severe vitamin A deficiency.: J Infect Dis. 1997 Jan;175(1):57-62. Unique Identifier : AIDSLINE MED/97138170; John GC; Nduati RW; Mbori-Ngacha D; Overbaugh J; Welch M; Richardson BA; Ndinya-Achola J; Bwayo J; Krieger J; Onyango F; Kreiss JK; Department of Pediatrics, University of Nairobi, Kenya.; The presence of human immunodeficiency virus type 1 (HIV-1) in genital secretions may be a determinant of vertical HIV-1 transmission. Cervical and vaginal secretions from HIV-1-seropositive pregnant women were evaluated to determine prevalence and correlates of HIV-1-infected cells in the genital tract. HIV-1 DNA was
Vertical transmission of human immunodeficiency virus type 1: seroreactivity by maternal antibodies to the carboxy region of the gp41 envelope glycoprotein.: J Infect Dis. 1997 Jan;175(1):63-9. Unique Identifier : AIDSLINE MED/97138171; Ugen KE; Srikantan V; Goedert JJ; Nelson RP Jr; Williams WV; Weiner DB; Department of Medical Microbiology and Immunology, University of South; Florida College of Medicine, Tampa 33612, USA.; Maternal antibodies against the envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) have previously been suggested to be important in influencing the rate of vertical transmission. In this study, serum antibody responses in mothers who did or did not transmit HIV-1 infection to their children were mea
Lineage commitment in the thymus: only the most differentiated TCRhibcl-2hi) subset of CD4+CD8+ thymocytes has selectively terminated CD4 or CD8 synthesis.: J Exp Med. 1996 Dec 1;184(6):2091-9. Unique Identifier : AIDSLINE MED/97130403; Punt JA; Suzuki H; Granger LG; Sharrow SO; Singer A; Experimental Immunology Branch, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland, USA.; Lineage commitment is a developmental process by which individual CD4+CD8+ (double positive, DP) thymocytes make a decision to differentiate into either CD4+ or CD8+ T cells. However, the molecular event(s) that defines lineage commitment is controversial. We have previously proposed that lineage commitment in DP thym
Induction of murine acquired immunodeficiency syndrome (MAIDS) in allophenic mice generated from strains susceptible and resistant to disease.: J Exp Med. 1996 Dec 1;184(6):2101-8. Unique Identifier : AIDSLINE MED/97157291; Sechler JM; Lawler A; Hartley JW; Morse HC 3rd; McCarty TC; Swofford R; Rosenberg AS; Division of Hematologic Products, Food and Drug Administration,; Bethesda, Maryland 20892, USA.; To examine whether a retroviral disease can be controlled in animals in which cells from a resistant strain coexist in a state of immunological tolerance with cells from a susceptible strain, allophenic mice were constructed and infected with LP-BM5 murine leukemia viruses which induce a fatal disorder, termed murine
Apoptosis of Fashigh CD4+ synovial T cells by borrelia-reactive Fas-ligand(high) gamma delta T cells in Lyme arthritis.: J Exp Med. 1996 Dec 1;184(6):2109-17. Unique Identifier : AIDSLINE MED/97130404; Vincent MS; Roessner K; Lynch D; Wilson D; Cooper SM; Tschopp J; Sigal LH; Budd RC; Department of Medicine, University of Vermont College of Medicine,; Burlington 05405-0068, USA.; The function of the minor subset of T lymphocytes bearing the gamma delta T cell antigen receptor is uncertain. Although some gamma delta T cells react to microbial products, responsiveness has only rarely been demonstrated toward a bacterial antigen from a naturally occurring human infection. Synovial fluid lymphocyt
Resting memory CD8+ T cells are hyperreactive to antigenic challenge in vitro.: J Exp Med. 1996 Dec 1;184(6):2141-51. Unique Identifier : AIDSLINE MED/97130407; Pihlgren M; Dubois PM; Tomkowiak M; Sjogren T; Marvel J; Laboratoire de Biologie Moleculaire et Cellulaire de Ecole Normale; Superieure Lyon centre National de la Recherche Scientifique Unite; Mixte de Recherche, France.; The characteristics of CD8+ T cells responsible for memory responses are still largely unknown. Particularly, it has not been determined whether different activation thresholds distinguish naive from memory CD8+ T cell populations. In most experimental systems, heterogeneous populations of primed CD8+ T cells can be i
Aerosol insulin induces regulatory CD8 gamma delta T cells that prevent murine insulin-dependent diabetes.: J Exp Med. 1996 Dec 1;184(6):2167-74. Unique Identifier : AIDSLINE MED/97130409; Harrison LC; Dempsey-Collier M; Kramer DR; Takahashi K; Walter and Eliza Hall Institute of Medical Research, Royal Melbourne; Hospital, Parkville, Australia.; Cellular immune hyporesponsiveness can be induced by the presentation of soluble protein antigens to mucosal surfaces. Most studies of mucosa-mediated tolerance have used the oral route of antigen delivery and few have examined autoantigens in natural models of autoimmune disease. Insulin is an autoantigen in humans a
Systemic T cell-independent tumor immunity after transplantation of universal receptor-modified bone marrow into SCID mice.: J Exp Med. 1996 Dec 1;184(6):2261-9. Unique Identifier : AIDSLINE MED/97130418; Hege KM; Cooke KS; Finer MH; Zsebo KM; Roberts MR; Department of Immunology and Cell Biology, Cell Genesys Inc., Foster; City, California 94404, USA.; Gene modification of hematopoietic stem cells (HSC) with antigen-specific, chimeric, or universal immune receptors (URs) is a novel but untested form of targeted immunotherapy. A human immunodeficiency virus (HIV) envelope-specific UR consisting of the extracellular domain of human CD4 linked to the zeta chain of th
Antagonist HIV-1 Gag peptides induce structural changes in HLA B8.: J Exp Med. 1996 Dec 1;184(6):2279-86. Unique Identifier : AIDSLINE MED/97130420; Reid SW; McAdam S; Smith KJ; Klenerman P; O'Callaghan CA; Harlos K; Jakobsen BK; McMichael AJ; Bell JI; Stuart DI; Jones EY; Laboratory of Molecular Biophysics, Oxford, United Kingdom.; SCOTT@BIOP.OX.AC.UK; In the cellular immune response, recognition by CTL-TCRs of viral antigens presented as peptides by HLA class I molecules, triggers destruction of the virally infected cell (Townsend, A.R.M., J. Rothbard, F.M. Gotch, G. Bahadur, D. Wraith, and A.J. McMichael. 1986. Cell. 44:959-968). Altered peptide ligands (APLs) whi
Cross-linking of Fas by antibodies to a peculiar domain of gp120 V3 loop can enhance T cell apoptosis in HIV-1-infected patients.: J Exp Med. 1996 Dec 1;184(6):2287-300. Unique Identifier : AIDSLINE MED/97130421; Silvestris F; Nagata S; Cafforio P; Silvestris N; Dammacco F; Department of Biomedical Sciences and Human Oncology, University of; Bari, Italy.; Previous studies have demonstrated that T cell-reactive antibodies in HIV-1 infection contribute to lymphocyte depletion by cytotoxicity that involves differential membrane targets, such as the 43.5-kD receptor on CEM cells. Here, we show that these antibodies bind Fas as result of a molecular mimicry of the gp120. Bo
Efficient interaction of HIV-1 with purified dendritic cells via multiple chemokine coreceptors.: J Exp Med. 1996 Dec 1;184(6):2433-8. Unique Identifier : AIDSLINE MED/97130437; Granelli-Piperno A; Moser B; Pope M; Chen D; Wei Y; Isdell F; O'Doherty U; Paxton W; Koup R; Mojsov S; Bhardwaj N; Clark-Lewis I; Baggiolini M; Steinman RM; Theodor Kocher Institute, Bern, Switzerland.; HIV-1 actively replicates in dendritic cell (DC)-T cell cocultures, but it has been difficult to demonstrate substantial infection of purified mature DCs. We now find that HIV-1 begins reverse transcription much more efficiently in DCs than T cells, even though T cells have higher levels of CD4 and gp120 binding. DCs
Copper(II) interactions with an experimental antiviral agent, I-deoxynojirimycin, and oxygen activation by resulting complexes.: J Inorg Biochem. 1996 Dec;64(4):231-46. Unique Identifier : AIDSLINE MED/97073703; Jezowska-Bojczuk M; Bal W; Kasprzak KS; Laboratory of Comparative Carcinogenesis, National Cancer Institute,; Frederick Cancer Research and Development Center, Maryland, USA.; 1-deoxynojirimycin (DNJ), a 5-imino analog of 1-deoxyglucose, is a potent inhibitor of alpha-glucosidase 1. DNJ and its derivatives have been considered as experimental drugs against human HIV-1 and hepatitis B viruses. Since amino and imino ligands have a high affinity for copper, it seems possible that biological ac
Massage therapy improves behavior in neonates born to HIV-positive mothers.: J Pediatr Psychol. 1996 Dec;21(6):889-97. Unique Identifier : AIDSLINE MED/97145059; Scafidi F; Field T; Touch Research Institute, University of Miami School of Medicine,; Florida 33101, USA.; Assigned randomly 28 neonates born to HIV-positive mothers to a massage therapy or control group. The treatment infants were given three 15-minute massages daily for 10 days. The massaged group showed superior performance on almost every Brazelton newborn cluster score and had a greater daily weight gain at the end of
Solid phases of delavirdine mesylate.: J Pharm Sci. 1996 Aug;85(8):834-41. Unique Identifier : AIDSLINE MED/97016647; Bergren MS; Chao RS; Meulman PA; Sarver RW; Lyster MA; Havens JL; Hawley M; Pharmacia and Upjohn Inc., Kalamazoo, MI 49001, USA.; Delavirdine mesylate was recrystallized from solution under a variety of conditions. Seven crystal forms and a stable amorphous phase were isolated from solution. Two of these crystal forms were polymorphic anhydrates: from XI (U-90152T) and form VIII
High-performance liquid chromatographic analysis of 2'-fluoro-2',3'-dideoxyadenosine and 2'-fluoro-2',3'-dideoxyinosine in dog plasma and urine.: J Pharm Sci. 1996 Aug;85(8):890-2. Unique Identifier : AIDSLINE MED/97016658; Campbell DA; Shah VR; Srinivas NR; Shyu WC; Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb; Pharmaceutical Research Institute, Bristol-Myers Squibb Company,; Princeton, NJ 08543, USA.; A high-performance liquid chromatographic assay was developed and validated for a simulataneous determination of 2 -fluoro-2 3 -dideoxyadenosine (FddA) and its metabolite, 2 -fluoro-2 ,3 -dideoxyinosine (Fddl) in dog plasma and urine. In vitro, FddA and Fddl exhibit activity against human immunodeficiency virus (HIV)
Colposcopic biopsies versus loop electrosurgical excision procedure cone histology in human immunodeficiency virus-positive women.: J Reprod Med. 1996 Sep;41(9):653-7. Unique Identifier : AIDSLINE MED/97041918; Del Priore G; Gilmore PR; Maag T; Warshal DP; Cheon TH; Department of Obstetrics and Gynecology, New York University School of; Medicine, New York, USA.; OBJECTIVE: To compare the discrepancy between colposcopically directed punch biopsy and excisional cone biopsy in human immunodeficiency-positive (HIV+) vs. HIV-negative (HIV-) women. STUDY DESIGN: We performed a case-control analysis of women treated with excisional cone biopsy after an abnormal colposcopic punch bio
Synthesis and bioactivity of novel bis(heteroaryl)piperazine BHAP) reverse transcriptase inhibitors: structure-activity relationships and increased metabolic stability of novel substituted pyridine analogs.: J Med Chem. 1996 Dec 20;39(26):5267-75. Unique Identifier : AIDSLINE MED/97133459; Genin MJ; Poel TJ; Yagi Y; Biles C; Althaus I; Keiser BJ; Kopta LA; Friis JM; Reusser F; Adams WJ; Olmsted RA; Voorman RL; Thomas RC; Romero DL; Pharmacia & Upjohn, Kalamazoo, Michigan 49001, USA.; The major route of metabolism of the bis(heteroaryl)piperazine BHAP) class of reverse transcriptase inhibitors (RTIs), atevirdine and delavirdine , is via oxidative N-dealkylation of the 3-ethyl- or 3-isopropylamino substituent on the pyridine ring. Th
Synthesis and HIV inhibition activity of 2',3'-dideoxy-3'-C-hydroxymethyl nucleosides.: J Med Chem. 1996 Dec 20;39(26):5276-80. Unique Identifier : AIDSLINE MED/97133460; Lee-Ruff E; Ostrowski M; Ladha A; Stynes DV; Vernik I; Jiang JL; Wan WQ; Ding SF; Joshi S; Department of Chemistry, York University, Toronto, Ontario, Canada.; A series if 2 ,3 -dideoxy-3 -C-hydroxymethyl purine nucleosides were prepared based on the photochemical ring expansion of a chiral cyclobutanone precursor, 2S)-trans-2,3-bis[(benzoyloxy)methyl]cyclobutanone, in the presence of a 6-substituted purine. Both alpha- and beta-anomers are produced in this transformation. D
A brief survey of the current sexual practices of a population admitted for inpatient treatment of drug dependence.: J Sex Marital Ther. 1996 Fall;22(3):203-8. Unique Identifier : AIDSLINE MED/97034997; Burke WM; Dhopesh V; Lainfester C; HealthPro/United HealthCare, Westborough, MA 01581, USA.; We studied a population of high-risk drug users concerning their current sexual practices. They had a pattern of inconsistent or infrequent condom use. Only 11.5% reported always using condoms; 38.2% reported never using them; and 50.3% reported using them sometimes. Experimental educational programs have demonstrated
[Large granular lymphocyte leukemia]: Rinsho Byori. 1996 Oct;44(10):917-26. Unique Identifier : AIDSLINE MED/97091506; Mizuki M; Tagawa S; Shibano M; Hirota T; Machii T; Kitani T; Ohsawa M; Aozasa K; Nojima J; Department of Hematology and Oncology, Osaka University Medical; School, Suita.; Large granular lymphocyte leukemia (LGLL) is defined as clonal proliferation of LGLs in peripheral blood. The following studies were conducted to address some issues in chronic LGLL. (1) Chronic LGLL is characterized by the indolent course, and the diagnosis of leukemia is difficult in such patients as those without d
[Future prospects of emergency laboratory tests--problems of immunoserologic tests]: Rinsho Byori. 1996 Oct;44(10):956-61. Unique Identifier : AIDSLINE MED/97091512; Obana Y; Furuta I; Ohba Y; Department of Clinical Pathology, Kinki University School of Medicine,; Osaka-Sayama.; Regarding problems in emergency and urgent immunoserologic tests, I mainly focused on infectious diseases and CPR and discussed the correspondence of dangerous needle stick injuries, and the significance of emergency CRP measurement in various body fluids using highly sensitive determination methods. The actual condit
Predictors of HIV-related risk behaviors among heterosexuals in alcoholism treatment.: J Stud Alcohol. 1996 Sep;57(5):486-93. Unique Identifier : AIDSLINE MED/97011536; Woods WJ; Avins AL; Lindan CP; Hudes ES; Boscarino JA; Clark WW; Center for AIDS Prevention Studies, University of California, San; Francisco 94105, USA.; OBJECTIVE: To determine which measures of alcohol and drug use are associated with HIV-related sexual risk and protective behaviors. METHOD: Entrants (N = 743, 72% male) to alcoholism treatment clinics underwent a structured interview including an assessment of demographics, substance abuse characteristics and sexual
[Rates of human immunodeficiency virus (HIV) infection in intravenous drug addicts from the Barcelona area, according to sex and age of drug consumption onset]: Med Clin (Barc). 1996 Jan 27;106(3):87-90. Unique Identifier : AIDSLINE MED/97106194; Egea JM; Tor J; Muga R; Roca J; Rodriguez R; Navio M; Rey-Joly C; Unidad de Desintoxicacion, Hospital Universitario Germans Trias i; Pujol, Barcelona.; BACKGROUND: The differences in the rates of HIV infection in intravenous drug addicts according to the age of onset of drug consumption, sex and length of intake were evaluated. METHODS: The study sample was made up of 650 intravenous drug addicts (535 males and 115 females) admitted to a Hospital Detoxication Unit ov
[Intestinal occlusion caused by ileocolic tuberculosis in a patient with human immunodeficiency virus infection (letter)]: Med Clin (Barc). 1996 Feb 3;106(4):157. Unique Identifier : AIDSLINE MED/97106190; Rodriguez Rodriguez E; Hernando Alonso J; Prieto de Paula JM; Arribas Escobar V
Enhanced engraftment of HTLV-I-infected human T cells in severe combined immunodeficiency mice by anti-asialo GM-1 antibody treatment.: Microbiol Immunol. 1996;40(1):39-44. Unique Identifier : AIDSLINE MED/97025315; Ishihara S; Okayama A; Nagatomo Y; Murai K; Yamashita R; Okamoto M; Shima T; Sasaki T; Mueller N; Tachibana N; Tsubouchi H; Second Department of Internal Medicine, Miyazaki Medical College,; Japan.; The effects of anti-asialo GM-1 antibody (AAGM) treatment on the engraftment of human T-cell leukemia virus type I HTLV-I)-infected human T cells in severe combined immunodeficiency (SCID) mice were studied. The frequency of tumor formation in an HTLV-I-transformed human T-cell line, MT-2 cells, at the site of inocula
A study of two procedures of HIV-1 isolation from whole blood cultures.: Microbiol Immunol. 1996;40(3):195-200. Unique Identifier : AIDSLINE MED/97088765; Shen L; Hober D; Benyoucef S; Ajana F; Gerard Y; Lion G; Vermersch A; Bocket-Mouton L; Mouton Y; Wattre P; Laboratoire de Virologie, Bat IRFPPS, CHU, Lille, France.; Culture techniques for isolation of HIV-1 from small amounts of whole blood (WB) treated with anticoagulant have been reported and gave results identical to those of culture of separated peripheral blood mononuclear cells. Some authors obtained much higher isolation rates when EDTA was used instead of heparin. We comp
Absence of human T-cell lymphotropic virus type I in cutaneous T-cell lymphoma [letter]: N Engl J Med. 1997 Jan 23;336(4):296-7. Unique Identifier : AIDSLINE MED/97136558; Kikuchi A; Nishikawa T; Yamaguchi K
Russian records rise in HIV [news]: Nature. 1997 Jan 9;385(6612):108. Unique Identifier : AIDSLINE MED/97144336
Applying viral load measurements to HIV care.: Nurse Pract. 1996 Aug;21(8):102-4. Unique Identifier : AIDSLINE MED/97025815; Klaus BD
Occupationally acquired HIV in health care workers [letter]: Nurse Pract. 1996 Sep;21(9):6-8, 11. Unique Identifier : AIDSLINE MED/97039236; Gershon RM; Byrns GE; Dunleavy ML
Evolution of tumor necrosis factor-alpha serum concentrations in HIV infected individuals treated with zidovudine.: Pathol Biol (Paris). 1996 Oct;44(8):716-9. Unique Identifier : AIDSLINE MED/97132476; Morlat P; Chene G; Ragnaud JM; Mercie P; Grobost F; Bernard N; Lacoste D; Beylot J; Aubertin J; Internal Medicine Department, Saint Andre Hospital, Bordeaux, France.; We studied the evolution of Tumor Necrosis Factor-alpha serum concentration (TNF-alpha) and CD4+ lymphocyte counts (CD4+) in a pilot cohort study of HIV-infected patients during the first year of zidovudine therapy. Data on 17 patients remaining asymptomatic during the one-year follow-up period (non progressors) were
Empyema with malakoplakic-like lesions by Rhodococcus equi as a presentation of HIV infection.: Pathologica. 1995 Oct;87(5):525-27. Unique Identifier : AIDSLINE MED/97021820; Calore EE; Vazquez CR; Perez NM; Cavaliere MJ; Curti R Jr; Campos Salles PS; Araujo MF; Instituto de Infectologia Emilio Ribas, S. Anatomia Patologica, S.; Paulo, Brazil.; Rhodococcus equi (Corynebacterium equi) is an aerobic actinomycetes, well described as a cause of pulmonary infection in different animals as horses, pigs and cows. This pathogen has a coccobacillar aspect and a variable acid-fast stain in tissues. Rare cases of human infection by Rhodococcus species were described, t
Characterization of natural killer and antibody-dependent cellular cytotoxicity of preterm infants against human immunodeficiency virus-infected cells.: Pediatr Res. 1996 Sep;40(3):498-503. Unique Identifier : AIDSLINE MED/97018674; Merrill JD; Sigaroudinia M; Kohl S; Department of Pediatrics, University of California, San Francisco,; USA.; The odds risk of vertical transmission of human immunodeficiency virus (HIV) to preterm infants is almost four times that of term infants and may relate to maternal and neonatal factors. We characterized the competence of early nonspecific cellular immunity, namely natural killer cytotoxicity (NKC) and antibody-depend
Bug busters [news]: Nurs Times. 1996 Nov 6-12;92(45):20-1. Unique Identifier : AIDSLINE MED/97154124; Cole A
Availability of HIV testing for pregnant women [news]: Nurs Times. 1996 Nov 13-19;92(46):15. Unique Identifier : AIDSLINE MED/97154139; MacDonagh SE
Nurses' Day at Rashtrapati Bhavan.: Nurs J India. 1996 Jul;87(7):146-7. Unique Identifier : AIDSLINE MED/97152110; Hind J
Comparison of changing autopsy trends in the Bronx population with acquired immunodeficiency syndrome.: Mod Pathol. 1996 Oct;9(10):1001-6. Unique Identifier : AIDSLINE MED/97058519; Concepcion L; Markowitz GS; Borczuk AC; Factor SM; Department of Pathology, Albert Einstein College of Medicine, Bronx,; New York 10461, USA.; The opportunistic infections, malignancies, and causes of death related to acquired immunodeficiency syndrome (AIDS) are changing, perhaps as a result of improved treatment, prophylaxis, and education. With its high percentage of persons who acquired the human immunodeficiency virus from intravenous drug (IVD) use, th
Digestive leishmaniasis in acquired immunodeficiency syndrome: a light and electron microscopic study of two cases.: Mod Pathol. 1996 Oct;9(10):966-9. Unique Identifier : AIDSLINE MED/97058513; Zimmer G; Guillou L; Gauthier T; Iten A; Saraga EP; Institute of Pathology, University Hospital, Lausanne, Switzerland.; An increased incidence of visceral leishmaniasis in patients infected with the human immunodeficiency virus (HIV) is observed in areas in which both infectious diseases are endemic. Intensive worldwide traveling has also resulted recently in an increasing number of leishmanial and HIV coinfections in nonendemic areas.
Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding.: Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15030-5. Unique Identifier : AIDSLINE MED/97140276; Wu H; Myszka DG; Tendian SW; Brouillette CG; Sweet RW; Chaiken IM; Hendrickson WA; Department of Biochemistry and Molecular Biophysics, Columbia; University, New York, NY 10032, USA.; The T-cell antigen coreceptor CD4 also serves as the receptor for the envelope glycoprotein gp120 of HIV. Extensive mutational analysis of CD4 has implicated residues from a portion of the extracellular amino-terminal domain (D1) in gp120 binding. However, none of these proteins has been fully characterized biophysica
Transduction of nondividing cells using pseudotyped defective high-titer HIV type 1 particles.: Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15266-71. Unique Identifier : AIDSLINE MED/97140318; Reiser J; Harmison G; Kluepfel-Stahl S; Brady RO; Karlsson S; Schubert M; Molecular and Medical Genetics Section, National Institute of; Neurological Disorders and Stroke, National Institutes of Health,; Bethesda, MD 20892, USA. jreiser@helix.nih.gov; The use of Moloney murine leukemia virus (Mo-MLV)-based vectors to deliver therapeutic genes into target cells is limited by their inability to transduce nondividing cells. To test the capacity of HIV-based vectors to deliver genes into nondividing cells, we have generated replication-defective HIV type 1 (HIV-1) repo
Cytotoxic T lymphocytes and viral turnover in HIV type 1 infection.: Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15323-8. Unique Identifier : AIDSLINE MED/97140329; Klenerman P; Phillips RE; Rinaldo CR; Wahl LM; Ogg G; May RM; McMichael AJ; Nowak MA; Nuffield Department of Medicine, John Radcliffe Hospital, Oxford,; United Kingdom.; To understand the role of the immune system in limiting HIV type 1 replication, it is critical to know to what extent the rapid turnover of productively infected cells is caused by viral cytopathicity or by immune-mediated lysis. We show that uncultured peripheral blood mononuclear cells of many patients contain cytot
CD8+ T-cell-derived soluble factor(s), but not beta-chemokines RANTES, MIP-1 alpha, and MIP-1 beta, suppress HIV-1 replication in monocyte/macrophages.: Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15341-5. Unique Identifier : AIDSLINE MED/97140332; Moriuchi H; Moriuchi M; Combadiere C; Murphy PM; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892, USA.; It has been demonstrated that CD8+ T cells produce a soluble factor(s) that suppresses human immuno-deficiency virus (HIV) replication in CD4+ T cells. The role of soluble factors in the suppression of HIV replication in monocyte/macrophages (M/M) has not been fully delineated. To investigate whether a CD8+ T-cell-der
Sensitivity to inhibition by beta-chemokines correlates with biological phenotypes of primary HIV-1 isolates.: Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15382-7. Unique Identifier : AIDSLINE MED/97140339; Jansson M; Popovic M; Karlsson A; Cocchi F; Rossi P; Albert J; Wigzell H; Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm,; Sweden.; Primary HIV-1 isolates were evaluated for their sensitivity to inhibition by beta-chemokines RANTES (regulated upon activation, normal T-cell expressed and secreted), macrophage inflammatory protein 1 alpha (MIP-1 alpha), and MIP-1 beta. Virus isolates of both nonsyncytium-inducing (NSI) and syncytium-inducing (SI) bi
Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein.: Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15394-9. Unique Identifier : AIDSLINE MED/97140341; Farci P; Shimoda A; Wong D; Cabezon T; De Gioannis D; Strazzera A; Shimizu Y; Shapiro M; Alter HJ; Purcell RH; Hepatitis Viruses Section, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892, USA.; The identification of the neutralization domains of hepatitis C virus (HCV) is essential for the development of an effective vaccine. Here, we show that the hypervariable region 1 (HVR1) of the envelope 2 (E2) protein is a critical neutralization domain of HCV. Neutralization of HCV in vitro was attempted with a rabbi
The relevance of opioids and opioid receptors on immunocompetence and immune homeostasis.: Proc Soc Exp Biol Med. 1996 Dec;213(3):248-57. Unique Identifier : AIDSLINE MED/97138282; Carr DJ; Rogers TJ; Weber RJ; Department of Microbiology, LSU Stanley S. Scott and Neuroscience; Centers, LSU Medical Center, New Orleans, Louisiana 70112-1393, USA.; Since the previous review on the role of opioids in the immune system, numerous investigative teams have contributed to the growing pool of information illustrating the tangible relationship between opioids and immune function, particularly as this association pertains to bacterial and viral pathogens. In addition, th
Effect of 5-alpha dihydrotestosterone on T-cell proliferation of the female nonobese diabetic mouse.: Proc Soc Exp Biol Med. 1996 Dec;213(3):287-93. Unique Identifier : AIDSLINE MED/97138288; Toyoda H; Takei S; Formby B; Division of Medical Genetics, Cedars-Sinai Medical Center, University; of California, Los Angeles, School of Medicine, 90048, USA.; Nonobese diabetic (NOD) mice develop type I diabetes spontaneously and have been utilized as a model for human autoimmune insulin-dependent diabetes. The disease is caused by the destruction of insulin-producing beta cells in the pancreatic islet of Langerhans by infiltrating inflammatory cells, which are primarily T
Posttraumatic stress disorder and illness behaviour in HIV+ patients.: Psychol Rep. 1996 Dec;79(3 Pt 1):843-5. Unique Identifier : AIDSLINE MED/97123861; Botha KF; Department of Psychology, Potchefstroom University for Christian; Higher Education, Vanderbijlpark, South Africa.; 24 asymptomatic HIV+ patients completed the Impact of Event Scale and the Illness Behaviour Questionnaire. Analysis indicated above-average scores on posttraumatic stress reactions as well as significant intercorrelations of this score with scores on three factors on the Illness Behaviour Questionnaire, namely, hypoch
Psychosocial factors in HIV-AIDS [editorial]: Psychother Psychosom. 1996;65(5):225-8. Unique Identifier : AIDSLINE MED/97048487; Emmelkamp PM
[Pseudomonas aeruginosa: dreadful also in the AIDS patient editorial)]: Rev Clin Esp. 1996 Oct;196(10):670-1. Unique Identifier : AIDSLINE MED/97122750; Bouza E
[Prevalence of the genotypes of the hepatitis C virus in Spanish drug addicts with chronic hepatitis C. Spanish Group for the Study of Viral Hepatitis in HIV Positive Patients]: Rev Clin Esp. 1996 Oct;196(10):673-7. Unique Identifier : AIDSLINE MED/97122751; Bravo R; Soriano V; Garcia-Samaniego J; Gonzalez J; Castro A; Colmenero M; Carballo E; Mas A; Gonzalez-Lahoz J; Instituto de Salud Carlos III. Madrid.; The hepatitis C virus (HCV) shows a wide genetic variability. The different variants of HCV have been classified into 9 types and different subtypes. Some genotypes have a characteristic geographic distribution and seem to be associated with precise ways of contagion. Serum samples from 107 spanish patients with chron
[Respiratory infection caused by Pseudomonas aeruginosa in patients with HIV infection]: Rev Clin Esp. 1996 Oct;196(10):678-83. Unique Identifier : AIDSLINE MED/97122752; Arrizabalaga Aguirreazaldegui J; Horcajada Gallego JP; Mentxaka Ugalde B; Rodriguez Arrondo F; Iribarren Loyarte JA; von Wichman de Miguel M; Garde Orbaiz C; Unidad de Enfermedades Infecciosas, Hospital Nuestra Senora de; Aranzazu, San Sebastian.; OBJECTIVE: Descriptive study of severe respiratory infections caused by Pseudomonas aeruginosa in patients with HIV infection. METHODS: Review of clinical records of HIV-positive patients admitted in a tertiary hospital from 1-1-1990 to 9-30-1995. The patients included in this study were those with P. aeruginosa recov
[Pseudomonas aeruginosa bacteremia in patients with HIV infection: clinicoepidemiologic study of 17 episodes]: Rev Clin Esp. 1996 Oct;196(10):684-91. Unique Identifier : AIDSLINE MED/97122753; Salavert Lleti S; Navarro Ibanez V; Roig Rico P; Breton Martinez JR; Ponz Diez F; Lopez Aldeguer J; Gobernado Serrano M; Servicio de Microbiologia Clinica, Hospital Universitario La Fe,; Valencia.; BACKGROUND: Bacteremic infection with Pseudomonas aeruginosa is an uncommon and late phenomenon in the natural history of infection with human immunodeficiency virus (HIV). Our objective was to study the clinico-epidemiological characteristics of P. aeruginosa bacteremia (PAB) in patients infected with HIV. PATIENTS A
[The spectrum of bronchopulmonary infection caused by Pseudomonas aeruginosa in patients infected with the human immunodeficiency virus]: Rev Clin Esp. 1996 Oct;196(10):692-7. Unique Identifier : AIDSLINE MED/97122754; Santin Cerezales M; Aranda Sanchez M; Podzamczer Palter D; Maiques Llacer JM; Rufi Rigau G; Gudiol Munte F; Servicio de Enfermedades Infecciosas, Ciutat Sanitaria i Universitaria; de Bellvitge, L'Hospitalet, Barcelona.; OBJECTIVE: To describe the clinical spectrum of bronchopulmonary infections caused by Pseudomonas aeruginosa in patients infected with HIV. METHODS: A retrospective study of cases with P. aeruginosa pneumonia and tracheo-bronchitis in patients infected with HIV, diagnosed over a 5-year period (January 1990-December 19
[Bacteremia caused by Pseudomonas aeruginosa in patients with AIDS]: Rev Clin Esp. 1996 Oct;196(10):698-702. Unique Identifier : AIDSLINE MED/97122755; Bouza Santiago E; Blazquez Garrido R; Rodriguez-Creixems M; Moreno Guillen S; Miralles Martin P; Alonso Fernandez R; Servicio de Microbiologia y Enfermedades Infecciosas, Hospital General; Universitario Gregorio Maranon, Madrid.; Severe infections caused by Pseudomonas aeruginosa are uncommon in patients infected with HIV. These infections are usually recurrent, bear a poor prognosis and their potential for nosocomial transmission is questioned. From May 1991 to December 1994, a total of 2,739 admissions were recorded at the VIH Unit in our ho
[Vasculitis associated with HIV infection]: Rev Clin Esp. 1996 Oct;196(10):714-20. Unique Identifier : AIDSLINE MED/97122759; Fernandez-Miranda Parra C; Rubio Garcia R; Pulido Ortega F; Servicio de Medicina Interna, Hospital Universitario 12 de Octubre,; Madrid.
[Usefulness of the bone marrow examination in HIV infected patients (letter)]: Rev Clin Esp. 1996 Oct;196(10):728-30. Unique Identifier : AIDSLINE MED/97122766; Moreno Garcia M
The emergence of HIV/AIDS in Africa.: Rev Epidemiol Sante Publique. 1996 Nov;44(6):511-8. Unique Identifier : AIDSLINE MED/97140653; De Cock KM; London School of Hygiene and Tropical Medicine, United Kingdom.; The recent spread of HIV/AIDS in Africa must be seen in the broader context of emerging infectious diseases, whose epidemiology results from changes in the equilibrium between the agent, the host, and the environment. For sexually transmitted agents such as HIV, epidemic spread requires a high basic reproductive rate
Signal transduction as target of gene therapy.: Recent Results Cancer Res. 1996;142:63-71. Unique Identifier : AIDSLINE MED/97048499; Moelling K; Strack B; Radziwill G; Institute of Medical Virology, University of Zurich, Switzerland.; Cancer development involves multistep events. Therapeutic approaches can be targeted against any of these events individually or in combination. Pancreatic cancer can involve activation of Ki-Ras, overexpression of Myc or ErbB-2, and mutational inactivation of functional p53. Three approaches with nucleic acid-based t
[Lymphotropic viruses type I and II in pregnant women in Yucatan]: Rev Invest Clin. 1996 Sep-Oct;48(5):383-4. Unique Identifier : AIDSLINE MED/97122794; Gongora-Biachi RA; Gonzalez-Martinez P; Castro-Sansores C; Vivas-Rosel ML; Gasque-Lopez F; Garrido-Hadad E; Laboratorio de Hematologia, entro de Investigaciones Regionales Dr.; Hideyo Noguchi, Universidad Autonoma de Yucatan, Merida, Yucatan,; Mexico.; No antibodies against HTLV-I and HTLV-II were detected in 590 gestating women residing in the Yucatan peninsula sampled between Jan/92 and May/93.
Human immunodeficiency-virus-related pulmonary infections in children.: Semin Respir Infect. 1996 Sep;11(3):173-83. Unique Identifier : AIDSLINE MED/97037528; McSherry GD; Department of Pediatrics, UMD-New Jersey Medical School, Newark, USA.; Increasing numbers of children with human immunodeficiency virus HIV) infection continue to be seen in the United States . Pulmonary infections constitute a major cause of morbidity and mortality in these children Pneumoncystis carinii pneumonia, pulmonary lymphoid hyperplasia/lymphoid
Analysis of uncontrolled treatment changes in HIV clinical trails.: Stat Med. 1996 Oct 15;15(19):2053-67. Unique Identifier : AIDSLINE MED/97051413; Lin HM; Hughes MD; Research Department, United Network for Organ Sharing, Richmond, VA; 23225, USA.; Some clinical trials involving subjects with the human immunodeficiency virus (HIV) allow a subject to change treatment when a marker of disease progression, for example, the CD4 cell count, falls below a defined threshold. Although the change does not involve a randomized control, there is considerable interest in as
[The eye and AIDS: ophthalmological consultation for AIDS screening, 1-year retrospective study]: Rev Med Suisse Romande. 1996 Jan;116(1):59-64. Unique Identifier : AIDSLINE MED/97025052; Lendi B; Herbort CP; Hopital ophtalmique Jules Gonin, Lausanne.
[Epidemiology of sexually transmitted diseases, with the exception of AIDS]: Rev Prat. 1996 Oct 15;46(16):1940-7. Unique Identifier : AIDSLINE MED/97132748; Warszawski J; Spira A; Sante publique, epidemiologie, reproduction humaine Hopital de; Bicetre, Le Kremlin-Bicetre.; Epidemiologic trends in sexually transmitted diseases strongly vary in the world. The situation is worrying in the developing countries. Both the incidences and prevalences are very high antibiotic resistance is expanding and interactions between sexually transmitted diseases and human immunodeficiency virus contribut
[Early syphilis]: Rev Prat. 1996 Oct 15;46(16):1948-51. Unique Identifier : AIDSLINE MED/97132749; Morel P; Service de dermatologie 2, Hopital Saint-Louis, Paris.; Given the transmission of Treponema pallidum during human sexual contact, syphilis now occurs in France only in sexually high-risk, disadvantaged populations. The English-language terminology of early syphilis has progressively replaced that of primary and secondary in French
Intrathecal immunoactivation in patients with HIV-1 infection is reduced by zidovudine but not by didanosine.: Scand J Infect Dis. 1996;28(4):329-33. Unique Identifier : AIDSLINE MED/97048557; Hagberg L; Norkrans G; Gisslen M; Wachter H; Fuchs D; Svennerholm B; Department of Infectious Diseases, University of Goteborg, Sweden.; The effect of zidovudine and didanosine on the cerebrospinal fluid (CSF) concentrations of neopterin was studied in 12 patients with human immunodeficiency virus type-1 (HIV-1) infection 3-12 months after initiation of antiretroviral therapy. Ten treatment periods on zidovudine and 7 on didanosine were analysed. The C
Human immunodeficiency virus infection of human bone marrow stromal myoid cells.: Scand J Infect Dis. 1996;28(4):335-40. Unique Identifier : AIDSLINE MED/97048558; Ercoli L; Sarmati L; Parisi SG; Mancino G; De Santis G; Bonanno E; Spagnoli LG; Rocchi G; Andreoni M; Division of Infectious Diseases, Tor Vergata University of Rome,; Italy.; In order to investigate the potential susceptibility of bone marrow stromal myoid cells to human immunodeficiency virus (HIV), a myoid cell population devoid of all other cellular components of marrow environment was isolated from 3 normal adult bone marrow samples. The bone marrow myoid cells were infected with 3 dif
Increased production of nitric oxide correlates with viral load and activation of mononuclear phagocytes in HIV-infected patients.: Scand J Infect Dis. 1996;28(4):341-5. Unique Identifier : AIDSLINE MED/97048559; Groeneveld PH; Kroon FP; Nibbering PH; Bruisten SM; van Swieten P; van Furth R; Department of Infectious Diseases, University Hospital Leiden, The; Netherlands.; The objective of our study was to determine the production of nitric oxide (NO) in patients infected with human immunodeficiency virus (HIV) and its relation to cellular immunity, activation of mononuclear phagocytes and the amount of circulating virus. Therefore, serum nitrate, the stable metabolite of NO, the number
Serum polymerase chain reaction for cytomegalovirus DNA for monitoring ganciclovir treatment in AIDS patients.: Scand J Infect Dis. 1996;28(4):347-51. Unique Identifier : AIDSLINE MED/97048560; Marenzi R; Cinque P; Ceresa D; Racca S; Lillo F; Lazzarin A; Division of Infectious Diseases, Scientific Institute San Raffaele,; Milan, Italy.; The virological response to antiviral treatment of cytomegalovirus ( CMV ) infection in patients with AIDS can be monitored by the identification and quantification of CMV pp65 antigen in blood polymorphonuclear leukocyte cells
Vertical transmission of hepatitis C virus infection.: Scand J Infect Dis. 1996;28(4):353-6. Unique Identifier : AIDSLINE MED/97048561; Fischler B; Lindh G; Lindgren S; Forsgren M; Von Sydow M; Sangfelt P; Alaeus A; Harland L; Enockson E; Nemeth A; Department of Paediatrics, Huddinge Hospital, Sweden.; Vertical transmission of hepatitis C virus (HCV) was studied in 58 infants of 55 mothers (3 sets of twins). HCV RNA analyses by the polymerase chain reaction (PCR) and alanine aminotransferase ALT) were performed on consecutive blood samples from birth to 18 months of age (0, 3, 9 and 18 months). Data on factors possi
Detection of Toxoplasma gondii in immunodeficient subjects by gene amplification: influence of therapeutics.: Scand J Infect Dis. 1996;28(4):383-6. Unique Identifier : AIDSLINE MED/97048567; Foudrinier F; Aubert D; Puygauthier-Toubas D; Rouger C; Beguinot I; Halbout P; Lemaire P; Marx-Chemla C; Pinon JM; Laboratoire de Parasitologie, Hopital Maison Blanche, France.; Polymerase chain reaction (PCR) technology was used to detect Toxoplasma gondii DNA in 253 immunodeficient subjects, 179 of whom were infected with the human immunodeficiency virus (HIV). The incidence of toxoplasmosis was 12.3% (22/179) in the HIV-infected subjects and 2.7% (2/74) in the remainder. The sensitivity of
Antimycobacterial synergism of clarithromycin and rifabutin.</