Binding and functional effects of transcriptional factor Sp1 on the murine interleukin-6 promotor. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Binding and functional effects of transcriptional factor Sp1 on the murine interleukin-6 promotor.

J Biol Chem. 1996 Mar 29;271(13):7330-5. Unique Identifier : AIDSLINE MED/96205905
Kang SH; Brown DA; Kitajima I; Xu X; Heidenreich O; Gryaznov S; Nerenberg M; Lynx Therapeutics, Hayward, California 94545, USA.

Abstract: The NF-kappaB and NF-IL6 elements have previously been shown to play an important role in regulation of both the mouse and human interleukin-6 gene. Between these two elements lies a G/C-rich sequence, which contains three repeats of the element CCACC, protein binding to which has not been previously characterized. In this study we demonstrate that the transcription factor Sp1 binds to these repeats and plays an important role in basal and in inducible expression of the murine interleukin-6 gene.
Keywords: Animal B-Lymphocytes Base Sequence Binding Sites Cell Line Cell Nucleus/METABOLISM DNA Footprinting DNA Primers Fibroblasts *Gene Expression Genes, pX Interleukin-6/*BIOSYNTHESIS/*GENETICS Luciferase/BIOSYNTHESIS Mice Mice, Transgenic Molecular Sequence Data *Promoter Regions (Genetics) Recombinant Proteins/BIOSYNTHESIS Repetitive Sequences, Nucleic Acid Transcription Factor, Sp1/*METABOLISM Transfection 3T3 Cells JOURNAL ARTICLEKWDanimalb-lymphocytesbasesequencebindingsitescelllinecellnucleus/metabolismdnafootprintingdnaprimersfibroblastsKWDgeneexpressiongenes,pxinterleukin-6/KWDbiosynthesis/KWDgeneticsluciferase/biosynthesismicemice,transgenicmolecularsequencedataKWDpromoterregions(genetics)recombinantproteins/biosynthesisrepetitivesequences,nucleicacidtranscriptionfactor,sp1/KWDmetabolismtransfection3t3cellsjournalarticle
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M9690914

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