Kaposi's sarcoma: advances and perspectives.

Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

Kaposi's sarcoma: advances and perspectives.

J Am Acad Dermatol. 1996 May;34(5 Pt 1):804-14. Unique Identifier : AIDSLINE MED/96209196
Schwartz RA; New Jersey Medical School, Newark 07103-2714, USA.

Abstract: Kaposi's sarcoma (KS) is an unusual neoplasm that has proved to be an enigma in many ways since its original description by Kaposi in 1872. Its epidemiology has stimulated tremendous interest, amplified markedly in 1981 when it became known as an original defining part of the complex of immune disorders now known as AIDS. The cell of origin, etiology, and therapy for both AIDS-associated and AIDS-unassociated KS continue as matters of intense investigation. In fact, whether it is a reactive hyperplasia or a true malignancy is still a matter of debate, as is the concept of multicentricity versus metastases. Epidemiologic studies suggest that a separate agent apart from HIV-1 may cause KS. A newly postulated KS-associated herpes virus may be linked. The role of the HIV-1 tat gene product, basic fibroblast growth factor, scatter factor, oncostatin M, and other factors that regulate the growth of KS cells are discussed, as well as therapeutic options.

Keywords: AIDS-Related Opportunistic Infections/PATHOLOGY/THERAPY/VIROLOGY Cell Lineage Cytokines/PHYSIOLOGY Fibroblast Growth Factor, Basic/PHYSIOLOGY Gene Products, tat/PHYSIOLOGY Growth Inhibitors/PHYSIOLOGY Hepatocyte Growth Factor/PHYSIOLOGY Herpesviridae Infections/PATHOLOGY Human Hyperplasia HIV-1 Peptides/PHYSIOLOGY *Sarcoma, Kaposi's/ETIOLOGY/PATHOLOGY/SECONDARY/THERAPY/VIROLOGY *Skin Neoplasms/ETIOLOGY/PATHOLOGY/THERAPY/VIROLOGY JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
960930
M9690907

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