Kinetics of cytokine expression during primary human immunodeficiency virus type 1 infection.

Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

Kinetics of cytokine expression during primary human immunodeficiency virus type 1 infection.

Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4386-91. Unique Identifier : AIDSLINE MED/96210653
Graziosi C; Gantt KR; Vaccarezza M; Demarest JF; Daucher M; Saag MS; Shaw GM; Quinn TC; Cohen OJ; Welbon CC; Pantaleo G; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892-1876, USA.

Abstract: In the present study, we have determined the kinetics of constitutive expression of a panel of cytokines [interleukin (IL) 2, IL-4, IL-6, IL-10, interferon gamma (IFN-gamma), and tumor necrosis factor alpha (TNF-alpha)] in sequential peripheral blood mononuclear cell samples from nine individuals with primary human immunodeficiency virus infection. Expression of IL-2 and IL-4 was barely detected in peripheral blood mononuclear cells. However, substantial levels of IL-2 expression were found in mononuclear cells isolated from lymph node. Expression of IL-6 was detected in only three of nine patients, and IL-6 expression was observed when transition from the acute to the chronic phase had already occurred. Expression of IL-10 and TNF-alpha was consistently observed in all patients tested, and levels of both cytokines were either stable or progressively increased over time. Similar to IL-10 and TNF-alpha, IFN-gamma expression was detected in all patients; however, in five of nine patients, IFN-gamma expression peaked very early during primary infection. The early peak in IFN-gamma expression coincided with oligoclonal expansions of CD8+ T cells in five of six patients, and CD8+ T cells mostly accounted for the expression of this cytokine. These results indicate that high levels of expression of proinflammatory cytokines are associated with primary infection and that the cytokine response during this phase of infection is strongly influenced by oligoclonal expansions of CD8+ T cells.

Keywords: Cells, Cultured Cytokines/*BIOSYNTHESIS Gene Expression Regulation, Viral Human HIV Infections/*IMMUNOLOGY *HIV-1 Interferon Type II/BIOSYNTHESIS Interleukin-10/BIOSYNTHESIS Interleukin-2/BIOSYNTHESIS Interleukin-4/BIOSYNTHESIS Interleukin-6/BIOSYNTHESIS Kinetics Lymph Nodes/IMMUNOLOGY Lymphocytes/*IMMUNOLOGY Receptors, Antigen, T-Cell, alpha-beta RNA, Messenger/ANALYSIS/BIOSYNTHESIS T-Lymphocyte Subsets/IMMUNOLOGY Time Factors Tumor Necrosis Factor/BIOSYNTHESIS JOURNAL ARTICLE
960930
M9690887

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