Long-lasting immune response induced by recombinant bacillus Calmette-Guerin (BCG) secretion system. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Long-lasting immune response induced by recombinant bacillus Calmette-Guerin (BCG) secretion system.

Scand J Immunol. 1996 Feb;43(2):202-9. Unique Identifier : AIDSLINE MED/96228952
Wada N; Ohara N; Kameoka M; Nishino Y; Matsumoto S; Nishiyama T; Naito M; Yukitake H; Okada Y; Ikuta K; Yamada T; School of Dentistry, Nagasaki University, Nagasaki City, Japan.

Abstract: The recombinant bacillus Calmette-Guerin (rBCG) secretion system utilizing an extracellular alpha antigen of Mycobacterium kansasii (alpha-K) was characterized biochemically and immunologically. The human immunodeficiency virus type 1 (HIV-1) p17gag B cell epitope fused to alpha-K was secreted in extremely large amounts. At least three mice out of seven inoculated with rBCG generated high titres of antibody to the epitope. The long-lasting antibody production persisted more than 14 months.
Keywords: Amino Acid Sequence Animal Base Sequence BCG Vaccine/GENETICS/*SECRETION Epitopes/GENETICS/IMMUNOLOGY Gene Products, gag/GENETICS/IMMUNOLOGY Genetic Vectors/*IMMUNOLOGY/*SECRETION Human HIV Antibodies/BIOSYNTHESIS/GENETICS HIV Antigens/GENETICS/IMMUNOLOGY HIV-1/GENETICS/IMMUNOLOGY Mice Mice, Inbred BALB C Molecular Sequence Data Recombinant Fusion Proteins/*SECRETION Support, Non-U.S. Gov't Time Factors Vaccines, Synthetic/*IMMUNOLOGY/*METABOLISM JOURNAL ARTICLEKWDaminoacidsequenceanimalbasesequencebcgvaccine/genetics/KWDsecretionepitopes/genetics/immunologygeneproducts,gag/genetics/immunologygeneticvectors/KWDimmunology/KWDsecretionhumanhivantibodies/biosynthesis/geneticshivantigens/genetics/immunologyhiv-1/genetics/immunologymicemice,inbredbalbcmolecularsequencedatarecombinantfusionproteins/KWDsecretionsupport,non-uKWDsKWDgov'ttimefactorsvaccines,synthetic/KWDimmunology/KWDmetabolismjournalarticle
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Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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