Enhanced T lymphocyte expression of LFA-1, ICAM-1, and the TNF receptor family member OX40 in HgCl2-induced systemic autoimmunity.

Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

Enhanced T lymphocyte expression of LFA-1, ICAM-1, and the TNF receptor family member OX40 in HgCl2-induced systemic autoimmunity.

Scand J Immunol. 1996 May;43(5):507-18. Unique Identifier : AIDSLINE MED/96233691
Roos A; Claessen N; Weening JJ; Aten J; Department of Pathology, University of Amsterdam, The; Netherlands.

Abstract: Injection of mercuric chloride into Brown Norway (BN) rats induces a T lymphocyte-dependent autoimmune syndrome. In order to investigate whether modification of adhesion and costimulatory molecules on T lymphocytes may be involved in early T lymphocyte activation by HgCl2, the authors analysed expression of these molecules in peripheral lymph node cells from BN rats at day 4 after injection of HgCl2. Tri-colour flow cytometry was performed for expression analysis within CD45RC-defined subsets of CD4+ and CD8+ cells. Compared to control rats, HgCl2-exposed rats showed increased numbers of lymphocytes, especially of T lymphocyte blast cells. The levels of LFA-1 expression as well as the fractions of ICAM-1 + cells were significantly increased in all CD45RC-defined subsets of CD4+ and CD8+ cells. Within the CD4 + CD45RC10 T lymphocyte population, HgCl2-injected rats showed a highly significant increase in the number of cells expressing OX40, which is a member of the TNF receptor family. Moreover, only CD4 + CD45RC10 blast cells of HgCl2-exposed rats showed decreased expression of CD43, increased expression of CD49d and decreased numbers of CD26 + cells. The results indicate that induction of autoimmunity by HgCl2 in BN rats is associated with altered expression of T lymphocyte costimulatory molecules, predominantly on CD4+ CD45RC10 cells, which may be caused by a direct effect of HgCl2 on these cells, and may precipitate further activation of T and B lymphocytes by HgCl2.

Keywords: Animal Antigens, CD27/*BIOSYNTHESIS Antigens, CD45/BIOSYNTHESIS/GENETICS Autoimmunity/*DRUG EFFECTS CD4-Positive T-Lymphocytes/IMMUNOLOGY CD8-Positive T-Lymphocytes/IMMUNOLOGY Female Intercellular Adhesion Molecule-1/*BIOSYNTHESIS Lymphocyte Function-Associated Antigen-1/*BIOSYNTHESIS Lymphocyte Transformation/DRUG EFFECTS Mercuric Chloride/*PHARMACOLOGY Phenotype Rats Rats, Inbred BN Receptors, Tumor Necrosis Factor/*PHYSIOLOGY Support, Non-U.S. Gov't T-Lymphocyte Subsets/*CHEMISTRY/IMMUNOLOGY JOURNAL ARTICLE
960930
M9690878

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