Different percentages of peripheral blood gamma delta + T cells in healthy individuals from different areas of the world.

Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

Different percentages of peripheral blood gamma delta + T cells in healthy individuals from different areas of the world.

Scand J Immunol. 1996 May;43(5):593-6. Unique Identifier : AIDSLINE MED/96233702
Esin S; Shigematsu M; Nagai S; Eklund A; Wigzell H; Grunewald J; Microbiology and Tumorbiology Center, Karolinska Institute,; Stockholm, Sweden.

Abstract: The frequency of gamma delta + T cells in the peripheral blood of 26 Turkish, 24 Swedish, 35 Japanese and 14 Asian' (non-Japanese) healthy blood donors and healthy volunteers were investigated by flow cytometry. In the Turkish group, 9.3% (median value) of the CD3+ peripheral blood T cells expressed the gamma delta T cell receptor. A similar level of gamma delta + T cells was found in the non-Japanese Asian' healthy volunteers (9.2%), while significantly lower values were detected in the Swedish (4.2%) and Japanese (4.5%) groups. These dramatic differences in normally occurring gamma delta + T cells in different groups of healthy individuals were further reflected by a low incidence of > 10% gamma delta + T cells in the Swedish (0/24) and Japanese (6/35) groups compared to the Turkish (12/26) and Asian' (5/14) groups. The described gamma delta + T cell differences between distinct ethnic groups are thus likely to be a consequence of environmental factors, but additional genetic influences cannot be ruled out. The present study demonstrates the potential importance of the ethnic origin and environmental history of subjects examined in studies of gamma delta + T cells-disease relations.

Keywords: Adolescence Adult Aged Asia/ETHNOLOGY Blood Donors/STATISTICS & NUMER DATA CD4-Positive T-Lymphocytes/CHEMISTRY CD8-Positive T-Lymphocytes/CHEMISTRY Female Flow Cytometry Human Japan/ETHNOLOGY Male Middle Age Receptors, Antigen, T-Cell, gamma-delta/*ANALYSIS Support, Non-U.S. Gov't Sweden/ETHNOLOGY Turkey/ETHNOLOGY JOURNAL ARTICLE
960930
M9690875

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