Infection and AIDS in adult macaques after nontraumatic oral exposure to cell-free SIV [see comments] NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Infection and AIDS in adult macaques after nontraumatic oral exposure to cell-free SIV [see comments]

Science. 1996 Jun 7;272(5267):1486-9. Unique Identifier : AIDSLINE MED/96234312
Baba TW; Trichel AM; An L; Liska V; Martin LN; Murphey-Corb M; Ruprecht RM; Division of Newborn Medicine, Department of Pediatrics, Tufts; University School of Medicine, Boston, MA 02111, USA.

Abstract: Unprotected receptive anal intercourse is a well-recognized risk factor for infection with human immunodeficiency virus-type 1 (HIV-1). Isolated human case reports have implicated HIV-1 transmission by oral-genital exposure. Adult macaques exposed nontraumatically to cell-free simian immunodeficiency virus (SIV) through the oral route became infected and developed acquired immunodeficiency syndrome (AIDS). The minimal virus dose needed to achieve systemic infection after oral exposure was 6000 times lower than the minimal dose required to achieve systemic infection after rectal exposure. Thus, unprotected receptive oral intercourse, even in the absence of mucosal lesions, should be added to the list of risk behaviors for HIV-1 transmission.
Keywords: Animal Disease Transmission, Horizontal Gastric Acid/PHYSIOLOGY Human HIV Infections/*TRANSMISSION/VIROLOGY *HIV-1 Intestinal Mucosa/VIROLOGY Macaca mulatta Mouth Mucosa/*VIROLOGY Rectum/VIROLOGY Risk Factors *Sex Behavior Sex Behavior, Animal Simian Acquired Immunodeficiency Syndrome/*TRANSMISSION/VIROLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. SIV/*PHYSIOLOGY Tongue/VIROLOGY Viremia JOURNAL ARTICLEKWDanimaldiseasetransmission,horizontalgastricacid/physiologyhumanhivinfections/KWDtransmission/virologyKWDhiv-1intestinalmucosa/virologymacacamulattamouthmucosa/KWDvirologyrectum/virologyriskfactorsKWDsexbehaviorsexbehavior,animalsimianacquiredimmunodeficiencysyndrome/KWDtransmission/virologysupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDsiv/KWDphysiologytongue/virologyviremiajournalarticle
Comment in: Science 1996 Jun 7;272(5267):1421-2
960930
M9690872

Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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