Risk factors for non-Hodgkin's lymphomas in acquired immunodeficiency syndrome (AIDS). NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Risk factors for non-Hodgkin's lymphomas in acquired immunodeficiency syndrome (AIDS).

Am J Epidemiol. 1996 Feb 15;143(4):374-9. Unique Identifier : AIDSLINE MED/96225621
Armenian HK; Hoover DR; Rubb S; Metz S; Martinez-Maza O; Chmiel J; Kingsley L; Saah A; Department of Epidemiology, Johns Hopkins University School of; Hygiene and Public Health, Baltimore, MD 21205, USA.

Abstract: The possibility that an agent in addition to the human immunodeficiency virus (HIV) may contribute to the etiology of non-Hodgkin's lymphoma in persons with acquired immunodeficiency syndrome (AIDS) was studied using participants from the Multicenter AIDS Cohort Study (MACS) of homosexual and bisexual men enrolled in 1984-1985 and also in 1987-1991. A nested case-control analysis was conducted. The primary source of information on potential exposures and characteristics of the participants was the baseline study entry interview that was conducted prior to the development of AIDS. A total of 84 cases of non-Hodgkin's lymphoma were identified and compared with 527 participants who developed AIDS but had no evidence of cancer. The groups were similar for most sociodemographic characteristics as well as sexual activity and past history of antecedent illnesses. Although the non-Hodgkin's lymphoma cases reported less frequent use of recreational drugs and cigarettes compared with other persons with AIDS, these differences were not significant. Non-Hodgkin's lymphoma cases reported more frequent intake of aspirin during the week before the interview. However, there were no differences between the comparison groups for long-term aspirin intake or intake of other analgesics. The absence of any specific and strong association between non-Hodgkin's lymphoma and the various behavior-related activities and exposures considered in this analysis suggests that these factors are not related to a second agent in the etiology of HIV-induced non-Hodgkin's lymphoma. The possibility that a very common agent in this study population or that differences in the nature of the immune dysfunction resulting from HIV infection could act as a cofactor for HIV-induced non-Hodgkin's lymphoma cannot be excluded.
Keywords: Adult Bisexuality Case-Control Studies Environmental Exposure Homosexuality, Male Human Lymphoma, AIDS-Related/EPIDEMIOLOGY/*ETIOLOGY Lymphoma, Non-Hodgkin's/EPIDEMIOLOGY/*ETIOLOGY Male Population Surveillance Prospective Studies Risk Factors Support, U.S. Gov't, P.H.S. United States/EPIDEMIOLOGY Urban Health JOURNAL ARTICLE MULTICENTER STUDYKWDadultbisexualitycase-controlstudiesenvironmentalexposurehomosexuality,malehumanlymphoma,aids-related/epidemiology/KWDetiologylymphoma,non-hodgkin's/epidemiology/KWDetiologymalepopulationsurveillanceprospectivestudiesriskfactorssupport,uKWDsKWDgov't,pKWDhKWDsKWDunitedstates/epidemiologyurbanhealthjournalarticlemulticenterstudy
960930
M9690864

Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1996. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1996. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .