Personality disorders predict onset of Axis I disorders and impaired functioning among homosexual men with and at risk of HIV infection.

Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

Personality disorders predict onset of Axis I disorders and impaired functioning among homosexual men with and at risk of HIV infection.

Arch Gen Psychiatry. 1996 Apr;53(4):350-7. Unique Identifier : AIDSLINE MED/96219935
Johnson JG; Williams JB; Goetz RR; Rabkin JG; Remien RH; Lipsitz JD; Gorman JM; Department of Psychiatry, Columbia University, New York, USA.

Abstract: BACKGROUND: A longitudinal study was conducted to investigate whether personality disorders (PDs) increase risk for the development of future Axis I disorders and serious functional impairment among human immunodeficiency virus (HIV)-seropositive and HIV-seronegative homosexual men. METHOD: Baseline assessments of PDs, Axis I disorders and symptoms, and Global Assessments of Functioning were conducted with a community sample of 107 (66 HIV-positive and 41 HIV-negative) homosexual men participating in a longitudinal study with semiannual interviews over 3 years. RESULTS: Logistic regression analysis indicated that PDs predicted onset of subsequent Axis I disorders after controlling for both HIV status and lifetime Axis I history (adjusted odds ratio, 4.31; P=.01; 95% confidence interval, 1.39 to 13.32). Of the 21 participants with PDs, 16 (76%) were subsequently diagnosed with Axis I disorders on at least one occasion. By contrast, only 36 (42%) of the 86 participants without PDs were subsequently diagnosed with Axis I disorders. Further, 33% of the participants with PDs, in comparison with only 8% of those without PDs, were assigned Global Assessments of Functioning scores of 50 or lower, indicating serious impairment during the postbaseline study period (adjusted odds ratio, 5.70; P<.005; 95% confidence interval, 1.66 to 19.53). CONCLUSION: Personality disorders may contribute to increased risk for onset of Axis I disorders and serious impairment among homosexual men regardless of HIV serologic status.

Keywords: Adult Comorbidity *Homosexuality, Male Human HIV Infections/DIAGNOSIS/*EPIDEMIOLOGY HIV Seronegativity HIV Seropositivity/DIAGNOSIS/EPIDEMIOLOGY Incidence Longitudinal Studies Male Mental Disorders/DIAGNOSIS/*EPIDEMIOLOGY Middle Age Odds Ratio Personality Disorders/*DIAGNOSIS/EPIDEMIOLOGY Personality Inventory Prevalence Prospective Studies Psychiatric Status Rating Scales Risk Factors Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE
960930
M9690851

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