Envelope gene sequences of human T-lymphotropic virus type 1 in Taiwan. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Envelope gene sequences of human T-lymphotropic virus type 1 in Taiwan.

Arch Virol. 1996;141(2):219-29. Unique Identifier : AIDSLINE MED/96195251
Lin MT; Chen YC; Chen PJ; Yang YC; Tang JL; Wu JM; Chuang SE; Yang CS; Department of Oncology, National Taiwan University Hospital,; Taipei.

Abstract: Three major types of HTLV-1 had been proposed, the Melanesian type, the Zairian type, and the cosmopolitan type, which was further divided into subtypes A, B and C, according to the phylogenetic tree constructed from LTR sequences of current HTLV-isolates. In this study, the envelope gene sequences of HTLV-1 from 9 Taiwanese were analyzed. Based on the phylogenetic tree constructed by unweighted pair group method and the sequence homology analysis by GCG computer programs, the envelope gene sequences of HTLV-1 proviruses from these 9 Taiwanese belonged to subtype A or subtype B of the cosmopolitan type and were closely related to HTLV-1 from Japan. Twelve subtype-specific nucleotide variations were deduced from the comparison of complete or partial envelope gene sequences of 16 HTLV-1 isolates of known subtypes as well as those of 9 Taiwanese. These data provided the basis for subtyping the cosmopolitan type of HTLV-1 by amplification of envelope gene sequences and restriction fragment length polymorphism studies. A more extensive survey based upon this proposal was warranted.
Keywords: Base Sequence DNA Primers DNA, Viral/CHEMISTRY/GENETICS *Genes, env Human HTLV-I/CLASSIFICATION/*GENETICS/ISOLATION & PURIF HTLV-I Infections/EPIDEMIOLOGY Japan Molecular Sequence Data *Phylogeny Polymerase Chain Reaction Prevalence Sequence Homology, Nucleic Acid Software Support, Non-U.S. Gov't Taiwan/EPIDEMIOLOGY Variation (Genetics) JOURNAL ARTICLEKWDbasesequencednaprimersdna,viral/chemistry/geneticsKWDgenes,envhumanhtlv-i/classification/KWDgenetics/isolation&purifhtlv-iinfections/epidemiologyjapanmolecularsequencedataKWDphylogenypolymerasechainreactionprevalencesequencehomology,nucleicacidsoftwaresupport,non-uKWDsKWDgov'ttaiwan/epidemiologyvariation(genetics)journalarticle
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M9690850

Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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