The therapeutic potential of antisense oligonucleotides.

Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

The therapeutic potential of antisense oligonucleotides.

Bioessays. 1995 Dec;17(12):1055-63. Unique Identifier : AIDSLINE MED/96112767
Sharma HW; Narayanan R; Division of Oncology, Roche Research Center, Hoffmann-La Roche; Inc., Nutley, NJ 07110, USA.

Abstract: Specific inhibition of gene expression by antisense agents provides the basis for rational drug discovery based on molecular targets. Due to the specificity of Watson-Crick base-pair hybridization, antisense oligodeoxynucleotides have been used extensively in attempts to inhibit gene expression in both in vitro and in vivo models. Analogues modified from normal phosphodiester oligodeoxynucleotides have entered clinical trials against diseases including AIDS and cancer. Although the precise mechanism of action of these drugs has not been clarified, these oligodeoxynucleotides offer considerable promise as novel molecular therapeutics. We review the recent attempts to harness the therapeutic potential of these oligodeoxynucleotides and appraise the near-term prospects for antisense technology.

Keywords: Acquired Immunodeficiency Syndrome/DRUG THERAPY Animal Clinical Trials Gene Expression Regulation/*DRUG EFFECTS Human Neoplasms/DRUG THERAPY Oligonucleotides, Antisense/PHARMACOLOGY/*THERAPEUTIC USE RNA, Messenger/ANTAGONISTS & INHIB JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
960930
M9690847

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