1996

Pathologic quiz case 2. Bilateral herpes zoster oticus.: Arch Otolaryngol Head Neck Surg. 1996 Feb;122(2):195, 197-8. Unique Identifier : AIDSLINE MED/96223616; Lee D; Belmont M; Lucente FE
[HIV infection with abdominal non-Hodgkin's lymphoma presenting as necrotizing pancreatitis]: Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr. 1996 Jan;164(1):82-4. Unique Identifier : AIDSLINE MED/96228939; Stoll M; Prokop M; Bernhards J; Benter T; Schmidt RE; Abteilungen Klinische Immunologie, Medizinische Hochschule; Hannover.
CD4 Expression by erythroid precursor cells in human bone marrow.: Blood. 1996 Mar 15;87(6):2275-82. Unique Identifier : AIDSLINE MED/96203792; Cleveland RP; Liu YC; Department of Pathology, Case Western Reserve University School; of Medicine, Cleveland, OH 44109 USA.; Flow cytometry was used to assess CD4 expression in 62 consecutive bone marrow specimens from patients with a variety of clinical conditions. Using a lysed-whole-blood technique for labeling with monoclonal antibodies, two populations of CD4+ cells were identified within the lymphocyte/blast-cell fraction in 58 (94%)
Identification of complement activation sites in human immunodeficiency virus type-1 glycoprotein gp120.: Blood. 1996 Mar 15;87(6):2329-36. Unique Identifier : AIDSLINE MED/96203799; Susal C; Kirschfink M; Kropelin M; Daniel V; Opelz G; Department of Transplantation Immunology, Institute of; Immunology, University of Heidelberg, Germany.; Recombinant glycoprotein 120 (rgp120) of human immunodeficiency virus type-1 (HIV-1) activates the human complement system in the absence of anti-gp120 antibodies. HIV-1 glycoprotein gp120 can dissociate from the viral envelope either spontaneously or after binding of HIV-1 to the CD4 molecule. As a consequence, gp120
Inhibition of CD4 cross-linking-induced lymphocytes apoptosis by vesnarinone as a novel immunomodulating agent: vesnarinone inhibits Fas expression and apoptosis by blocking cytokine secretion.: Blood. 1996 Mar 15;87(6):2361-8. Unique Identifier : AIDSLINE MED/96203800; Oyaizu N; McCloskey TW; Than S; Pahwa S; Department of Pediatrics, North Shore University Hospital-Cornell; University Medical College, New York, NY 11030, USA.; Evidence is accumulating that T cells from human immunodeficiency virus type 1 (HIV-1)-infected individuals show accelerated cell death through apoptosis. We have recently demonstrated that the cross-linking of CD4 molecules (CD4XL) results in death of normal peripheral T cells through apoptosis and imbalanced cytokin
Epstein-Barr virus (EBV)-associated lymphoproliferations in severe combined immunodeficient mice transplanted with Hodgkin's disease lymph nodes: implications of EBV-positive bystander B lymphocytes rather than EBV-infected Reed-Sternberg cells.: Blood. 1996 Mar 15;87(6):2435-42. Unique Identifier : AIDSLINE MED/96203812; Meggetto F; Muller C; Henry S; Selves J; Mariame B; Brousset P; Saati TA; Delsol G; Department of Hematology, CHU-Purpan, Toulouse, France.; To establish an in vivo model for the study of Hodgkin s disease and Reed-Sternberg (RS) cells, 25 lymph node tissue samples involved by Hodgkin s disease were grafted into severe combined immunodeficiency (SCID) mice. Ten Epstein-Barr virus (EBV)-associated tumors were obtained in SCID mice. EBV-positive tumors growi
Reticuloendothelial origin and metastasis of Kaposi's sarcoma: historical update on the literature [letter]: Blood. 1996 Mar 15;87(6):2605. Unique Identifier : AIDSLINE MED/96203834; Cottoni F
Flow cytometric analysis of lung lymphocytes in lung transplant recipients.: Am J Respir Crit Care Med. 1996 Mar;153(3):1041-6. Unique Identifier : AIDSLINE MED/96185410; Crim C; Keller CA; Dunphy CH; Maluf HM; Ohar JA; Division of Pulmonology and Pulmonary Occupational Medicine,; Department of Internal Medicine, Saint Louis University Health; Sciences Center, Missouri 63110-0250, USA.; Lung transplantation is an accepted therapeutic modality in end-stage lung disease. Presently, histologic examination of tissue by transbronchial biopsy remains as the definitive diagnostic procedure for determining rejection. To begin addressing the usefulness of flow cytometric analysis of bronchoalveolar lavage flu
Immune dysregulation in the aging human lung.: Am J Respir Crit Care Med. 1996 Mar;153(3):1072-9. Unique Identifier : AIDSLINE MED/96185414; Meyer KC; Ershler W; Rosenthal NS; Lu XG; Peterson K; Department of Medicine, University of Wisconsin Medical School,; Madison 53792-3240, USA.; Aging has been associated with diminished lung function and increased susceptibility to lung infection. To determine whether changes suggestive of immune dysregulation and inflammation appear in the lungs of clinically normal individuals as a function of advancing age, we performed bronchoalveolar lavage (BAL) on disc
We reap what we sow [editorial] [see comments]: Am J Respir Crit Care Med. 1996 May;153(5):1472-3. Unique Identifier : AIDSLINE MED/96210187; Sbarbaro JA
Phenotypic and molecular characteristics of nasal mucosal gamma delta T cells in allergic and infectious rhinitis.: Am J Respir Crit Care Med. 1996 May;153(5):1655-65. Unique Identifier : AIDSLINE MED/96210216; Pawankar RU; Okuda M; Suzuki K; Okumura K; Ra C; Department of Otolaryngology, Nippon Medical School, Japan.; T cells expressing the T-cell receptor (TCR) gamma delta home in on various epithelia and may play an important role in local immunity to foreign antigens. The nasal mucosa is a potential site for chronic inflammatory diseases, yet little is known about the characteristics of nasal mucosal gamma delta T cells. Using f
Relationship of isoniazid resistance to human immunodeficiency virus infection in patients with tuberculosis [see comments]: Am J Respir Crit Care Med. 1996 May;153(5):1708-10. Unique Identifier : AIDSLINE MED/96210224; Asch S; Knowles L; Rai A; Jones BE; Pogoda J; Barnes PF; Department of Medicine, University of Southern California School; of Medicine, Los Angeles 90033, USA.; To investigate the relationship between isoniazid resistance and HIV infection in patients with tuberculosis, we evaluated data in the Los Angeles County tuberculosis registry on 1,506 patients for whom drug susceptibility results were available. Among 235 HIV-infected patients, isoniazid resistance was less common th
Clusters of lymphoma in ferrets.: Cancer Invest. 1996;14(3):225-30. Unique Identifier : AIDSLINE MED/96225465; Erdman SE; Kanki PJ; Moore FM; Brown SA; Kawasaki TA; Mikule KW; Travers KU; Badylak SF; Fox JG; Division of Comparative Medicine, Massachusetts Institute of; Technology, Cambridge 02139, USA.; Cluster outbreaks of lymphoma and leukemia have been associated with viral infections in many species including humans, cattle, and cats. This study describes epidemiological, clinical, and pathological features of cluster outbreaks of lymphoma in multiferret households and examines and compares the Aleutian disease v
IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses.: Immunity. 1996 May;4(5):471-81. Unique Identifier : AIDSLINE MED/96222810; Magram J; Connaughton SE; Warrier RR; Carvajal DM; Wu CY; Ferrante J; Stewart C; Sarmiento U; Faherty DA; Gately MK; Department of Biotechnology, Roche Institute of Molecular; Biology, Nutley, New Jersey 07110, USA.; IL-12 is a cytokine that can exert regulatory effects on T and NK cells and promote Th1 responses. To delineate further the physiologic role of IL-12 in immunity, mice deficient for this cytokine were generated. IL-12-deficient mice were impaired but not completely lacking in the ability to produce IFN gamma following
AIDS: newer concepts in the immunopathogenic mechanisms of human immunodeficiency virus disease.: Proc Assoc Am Physicians. 1995 Apr;107(1):1-7. Unique Identifier : AIDSLINE MED/96212056; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892-2520, USA.
Combination antiretroviral therapy for the treatment of human immunodeficiency virus type-1 infection.: Proc Assoc Am Physicians. 1995 Apr;107(1):19-27. Unique Identifier : AIDSLINE MED/96212058; Wilson CC; Hirsch MS; Infectious Disease Unit, Massachusetts General Hospital, Boston; 02114, USA.
AIDS-associated Kaposi's sarcoma: a new perspective of its pathogenesis and treatment.: Proc Assoc Am Physicians. 1995 Apr;107(1):8-18. Unique Identifier : AIDSLINE MED/96212057; Ensoli B; Gallo RC; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892-4255,; USA.
Prevalence of HIV in Quebec [letter; comment]: Can Med Assoc J. 1996 Feb 15;154(4):444, 446. Unique Identifier : AIDSLINE MED/96229934; Duval B; Cote L; Boulianne N; Guilbert E
Jehovah's Witnesses leading education drive as hospitals adjust to no blood requests.: Can Med Assoc J. 1996 Feb 15;154(4):557-60. Unique Identifier : AIDSLINE MED/96229949; Robb N; Jehovah s Witness representatives have visited more than 10 Canadian medical schools and 200 hospitals in an attempt to educate future and practising physicians about nonblood medicine. The trend is becoming more popular since the advent of HIV, and there are now about 100 bloodless medicine and surgery centres around
Centromeric instability of chromosome 1 resulting in multibranched chromosomes, telomeric fusions, and jumping translocations of 1q in a human immunodeficiency virus-related non-Hodgkin's lymphoma.: Cancer. 1995 Oct 1;76(7):1238-44. Unique Identifier : AIDSLINE MED/96223170; Sawyer JR; Swanson CM; Koller MA; North PE; Ross SW; Department of Pathology, University of Arkansas for Medical; Sciences, Little Rock, USA.; BACKGROUND. Acquired immunodeficiency syndrome-related non-Hodgkin s lymphomas are associated with the B-cell chromosomal translocation t(8;14)(q24; q32). The most common secondary chromosome aberrations in these patients involve 1q and are believed to be associated with tumor progression. A mechanism for the origin o
The investigation of Epstein-Barr viral sequences in 41 cases of Burkitt's lymphoma from Egypt: epidemiologic correlations.: Cancer. 1995 Oct 1;76(7):1245-52. Unique Identifier : AIDSLINE MED/96223171; Anwar N; Kingma DW; Bloch AR; Mourad M; Raffeld M; Franklin J; Magrath I; el Bolkainy N; Jaffe ES; National Cancer Institute, Cairo, Egypt.; BACKGROUND. Epstein-Barr virus (EBV) is associated with many human neoplasms, including Burkitt s lymphoma (BL). Endemic BL in central Africa is more often EBV-associated than BL in the United States , where seroconversion for EBV occurs somewhat later than in Africa. Therefore, the EBV
Enhanced human lymphokine-activated killer cell function after brief exposure to granulocyte-macrophage-colony stimulating factor.: Cancer. 1995 Oct 1;76(7):1253-60. Unique Identifier : AIDSLINE MED/96223172; Baxevanis CN; Dedoussis GV; Papadopoulos NG; Missitzis I; Beroukas C; Stathopoulos GP; Papamichail M; Department of Immunology, Hellenic Anticancer Institute, Athens,; Greece.; BACKGROUND. Lymphokine-activated killer (LAK) cell function can be generated in peripheral blood mononuclear cells (PBMC) after brief exposure of high dose interleukin-2 ( IL-2 ) over the course of 1 or 2 days culture in plain culture medium (IL-2-pulsed PBMC). The aim
High levels of AP-2-binding activity in cell lines infected with human T-cell leukemia virus type I: possible enhancement of AP-2 binding by human T-cell leukemia virus type I tax.: Cancer Res. 1996 Feb 15;56(4):779-82. Unique Identifier : AIDSLINE MED/96223686; Mori N; Prager D; Department of Medicine, Cedars-Sinai Medical Center, University; of California-Los Angeles School of Medicine 90048, USA.; Human T-cell leukemia virus type I (HTLV-I) is the etiological agent for adult T-cell leukemia and tropical spastic paraparesis/HTLV-I-associated myelopathy. Recently, the transcription factor AP-2 has been demonstrated to be capable of activating gene expression from HTLV-I long terminal repeat. To determine whether
[Risk of HIV infection after needle injuries]: Dtsch Med Wochenschr. 1996 May 10;121(19):A14. Unique Identifier : AIDSLINE MED/96233582; Weismann H
[Apoptosis of T-helper cells is massively increased in AIDS]: Dtsch Med Wochenschr. 1996 Jan 26;121(4):A14. Unique Identifier : AIDSLINE MED/96223710; Weismann H
[HIV-associated Pneumocystis carinii pneumonia, primary pentamidine inhalation prophylaxis notwithstanding. Are there differences with Pneumocystis carinii pneumonia without prophylaxis?]: Dtsch Med Wochenschr. 1996 Jan 26;121(4):83-9. Unique Identifier : AIDSLINE MED/96223711; Ewig S; Rockstroh JK; Schafer H; Leutner C; Pickenhain A; Luderitz B; Medizinische Universitatsklinik und Poliklinik sowie; Radiologische Universitatsklinik Bonn.; OBJECTIVE: To study the effect of pentamidine aerosol inhalation, known to be effective and well tolerated in the primary prevention of HIV-associated Pneumocystis carinii pneumonia (PCP), on the severity, on clinical and radiological findings and prognosis of break-through PCP. PATIENTS AND METHODS: Data were obtaine
Constitutive activation of NF-kappa B is essential for transformation of rat fibroblasts by the human T-cell leukemia virus type I Tax protein.: EMBO J. 1996 Feb 15;15(4):873-87. Unique Identifier : AIDSLINE MED/96181365; Yamaoka S; Inoue H; Sakurai M; Sugiyama T; Hazama M; Yamada T; Hatanaka M; Department of Viral Oncology, Institute for Virus Research, Kyoto; University, Japan.; Human T-cell leukemia virus type I (HTLV-I) encodes a 40 kDa trans-acting protein, Tax, that regulates transcription of both the proviral and cellular genes, and can transform rat fibroblasts. To determine the functional importance of its trans-acting capacities in cell transformation, we have examined two representat
Specific initiation and switch to elongation of human immunodeficiency virus type 1 reverse transcription require the post-transcriptional modifications of primer tRNA3Lys.: EMBO J. 1996 Feb 15;15(4):917-24. Unique Identifier : AIDSLINE MED/96181369; Isel C; Lanchy JM; Le Grice SF; Ehresmann C; Ehresmann B; Marquet R; Unite Propre de Recherche 9002 du Centre National de la; Recherche Scientifique, Strasbourg, France.; Initiation of RNA-dependent DNA synthesis by retroviral reverse transcriptases is generally considered as unspecific. In the case of human immunodeficiency virus type 1 (HIV-1), the natural primer is tRNA3Lys. We recently found evidence of complex interactions between tRNA3Lys and HIV-1 RNA that may be involved in the
Comparison of self-sustained sequence-replication reaction systems.: Eur J Biochem. 1996 Jan 15;235(1-2):256-61. Unique Identifier : AIDSLINE MED/96202944; Gebinoga M; Oehlenschlager F; Institute for Molecular Biotechnology, Jena, Germany.; The 3SR (self-sustained sequence-replication) reaction is a very efficient method for isothermal amplification of target DNA or RNA sequences in vitro. This method requires three enzymatic activities: reverse transcriptase, DNA-dependent RNA polymerase and Escherichia coli ribonuclease H. We have modified the original
HTLV-I and HTLV-II infections in subjects at risk for HIV-I infection from southeastern Italy (Apulia region).: Int J Cancer. 1996 Mar 15;65(6):746-50. Unique Identifier : AIDSLINE MED/96200256; Chironna M; Calabro ML; Quarto M; Germinario C; Fiore JR; Favero A; Potenza D; Chieco-Bianchi L; Barbuti S; Institute of Hygiene, University of Bari, Italy.; To assess the prevalence of HTLV-I and HTLV-II infections in different groups at risk for HIV-I infection, a study on 867 subjects was carried out by means of serological and PCR analyses. Serum specimens were collected from 268 intravenous drug users (IVDU), 66 homosexual men, 248 subjects with sexually transmitted d
Binding and functional effects of transcriptional factor Sp1 on the murine interleukin-6 promotor.: J Biol Chem. 1996 Mar 29;271(13):7330-5. Unique Identifier : AIDSLINE MED/96205905; Kang SH; Brown DA; Kitajima I; Xu X; Heidenreich O; Gryaznov S; Nerenberg M; Lynx Therapeutics, Hayward, California 94545, USA.; The NF-kappaB and NF-IL6 elements have previously been shown to play an important role in regulation of both the mouse and human interleukin-6 gene. Between these two elements lies a G/C-rich sequence, which contains three repeats of the element CCACC, protein binding to which has not been previously characterized. In
A soluble active mutant of HIV-1 integrase: involvement of both the core and carboxyl-terminal domains in multimerization.: J Biol Chem. 1996 Mar 29;271(13):7712-8. Unique Identifier : AIDSLINE MED/96205962; Jenkins TM; Engelman A; Ghirlando R; Craigie R; Laboratory of Molecular Biology, NIDDK, National Institutes of; Health, Bethesda, Maryland 20892-0560, USA.; Structural studies of human immunodeficiency virus type 1 (HIV-1) integrase have been impeded by the low solubility of the protein. By systematic replacement of hydrophobic residues, we previously identified a single amino acid change (F185K) that dramatically improved the solubility of the catalytic domain of HIV-1 i
Programming the Rous sarcoma virus protease to cleave new substrate sequences.: J Biol Chem. 1996 May 3;271(18):10538-44. Unique Identifier : AIDSLINE MED/96209975; Ridky TW; Bizub-Bender D; Cameron CE; Weber IT; Wlodawer A; Copeland T; Skalka AM; Leis J; Department of Biochemistry, Case Western Reserve University,; Cleveland, Ohio 44106, USA.; The Rous sarcoma virus protease displays a high degree of specificity and catalyzes the cleavage of only a limited number of amino acid sequences. This specificity is governed by interactions between side chains of eight substrate amino acids and eight corresponding subsite pockets within the homodimeric enzyme. We ha
Unexpected nephropathy.: Hosp Pract (Off Ed). 1996 May 15;31(5):43-4. Unique Identifier : AIDSLINE MED/96222794; Gamouras G; Brown M; Department of Internal Medicine, University of South Florida; College of Medicine, Tampa, USA.
Lymphocyte traffic changes induced by monolateral vagal denervation in mouse thymus and peripheral lymphoid organs.: J Neuroimmunol. 1996 Feb;64(2):115-22. Unique Identifier : AIDSLINE MED/96182329; Antonica A; Ayroldi E; Magni F; Paolocci N; Istituto di Patologia Generale, Cattedra de Fisiologia Umana,; Universita de Perugia, Italy.; In this report we show that after monolateral vagal denervation (vagotomy), performed at the cervical level, a transient effect, lasting about 24h, was produced on lymphocyte release from mouse thymus to peripheral lymphoid organs (spleen and lymph nodes). Labelling thymocytes in situ with fluorescein isothiocyanate (
Experimental allergic encephalomyelitis in the rat is inhibited by aminoguanidine, an inhibitor of nitric oxide synthase.: J Neuroimmunol. 1996 Feb;64(2):123-33. Unique Identifier : AIDSLINE MED/96182330; Zhao W; Tilton RG; Corbett JA; McDaniel ML; Misko TP; Williamson JR; Cross AH; Hickey WF; Department of Pathology, Dartmouth Medical School,; Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756 USA.; This study assessed the role of de novo nitric oxide (NO) production in the pathogenesis of experimental allergic encephalomyelitis (EAE) by using aminoguanidine (AG), an inhibitor of nitric oxide synthase (NOS), which preferentially inhibits the cytokine- and endotoxin-inducible isoform of NOS versus the constitutive
Lymphocyte counts of patients who have had skin cancer.: J Am Acad Dermatol. 1996 May;34(5 Pt 1):772-6. Unique Identifier : AIDSLINE MED/96209190; Czarnecki D; Meehan CJ; McColl I; Kulinskaya E; Austin Repatriation Medical Centre, Heidelberg West, Australia.; BACKGROUND: Investigations of lymphocyte counts in patients with skin cancer have given conflicting results, possibly because homogeneous groups of patients were not studied. OBJECTIVE: Our purpose was to measure lymphocyte counts in patients with skin cancer to determine whether any abnormalities were associated with
Kaposi's sarcoma: advances and perspectives.: J Am Acad Dermatol. 1996 May;34(5 Pt 1):804-14. Unique Identifier : AIDSLINE MED/96209196; Schwartz RA; New Jersey Medical School, Newark 07103-2714, USA.; Kaposi s sarcoma (KS) is an unusual neoplasm that has proved to be an enigma in many ways since its original description by Kaposi in 1872. Its epidemiology has stimulated tremendous interest, amplified markedly in 1981 when it became known as an original defining part of the complex of immune disorders now known as A
Nurses' attitudes toward caring for patients with acquired immunodeficiency syndrome.: J Prof Nurs. 1996 Mar-Apr;12(2):99-105. Unique Identifier : AIDSLINE MED/96204265; Baylor RA; McDaniel AM; Department of Nursing, Goshen College, IN 46526, USA.; The purpose of this study was to examine nurses attitudes toward caring for patients with acquired immunodeficiency syndrome (AIDS) and factors that might be related to these attitudes. One hundred thirty-eight (138) registered nurses responded to an anonymous mail survey. The survey instrument assessed the subjects
Intralesional vinblastine injections for the treatment of oral Kaposi's sarcoma: report of 10 patients with 2-year follow-up.: J Oral Maxillofac Surg. 1996 May;54(5):583-7; discussion 588-9. Unique Identifier : AIDSLINE MED/96209026; McCormick SU; New York Eye and Ear Infirmary, New York 10003, USA.; PURPOSE: This study evaluated the use of intralesional vinblastine injections for the treatment of the intraoral lesions of Kaposi s sarcoma. PATIENTS AND METHODS: Eighteen patients were treated with up to three intralesional injections of 0.1 mg/cc vinblastine. RESULTS: All lesions responded to the local injections;
Necrotizing fasciitis of the cervical region in an AIDS patient: report of a case.: J Oral Maxillofac Surg. 1996 May;54(5):638-40. Unique Identifier : AIDSLINE MED/96209037; Chidzonga MM; Department of Surgery, University of Zimbabwe, Medical School,; Avondale, Harare.
In vivo biodistribution, pharmacokinetic parameters, and brain uptake of 5-halo-y-methoxy(or ethoxy)-5,6-dihydro-3'-azido-3'-deoxythymidine diastereomers as potential prodrugs of 3'-azido-3'-deoxythymidine.: J Med Chem. 1996 Feb 16;39(4):826-33. Unique Identifier : AIDSLINE MED/96196372; Wang L; Morin KW; Kumar R; Cheraghali M; Todd KG; Baker GB; Knaus EE; Wiebe LI; University of Alberta, Edmonton, Canada.; A new class of 5-halo-6-alkoxy-5,6-dihydro-3 -azido-3 -deoxythymidine diastereomers (5-x-6-OR -5,6-dihydro-AZTs; X = I, Br, Cl; R = Me, Et) were evaluated as potential anti-AIDS prodrugs of 3 -azido-3 -deoxythimidine (AZT). In vivo regeneration of AZT from these 5-X-6-OR-5,6-dihydro-AZTs was examined in Balb/c mice af
Synthesis, chromatographic resolution, and anti-human immunodeficiency virus activity of (+/-)-calanolide A and its enantiomers.: J Med Chem. 1996 Mar 15;39(6):1303-13. Unique Identifier : AIDSLINE MED/96251034; Flavin MT; Rizzo JD; Khilevich A; Kucherenko A; Sheinkman AK; Vilaychack V; Lin L; Chen W; Greenwood EM; Pengsuparp T; Pezzuto JM; Hughes SH; Flavin TM; Cibulski M; Boulanger WA; Shone RL; Xu ZQ; MediChem Research, Inc., Lemont, Illinois 60439, USA.; The anti-HIV agent (+/-)-calanolide A (1) has been synthesized in a five-step approach starting with phloroglucinol [-->5-->6-->11-->18-->(+/-)-1], which includes Pechmann reaction, Friedel-Crafts acylation, chromenylation with 4,4-dimethoxy-2-methylbutan-2-ol, cyclization, and Luche reduction. Cyclization of chromene
Synthesis and antiviral activity of pyranosylphosphonic acid nucleotide analogues.: J Med Chem. 1996 Mar 15;39(6):1321-30. Unique Identifier : AIDSLINE MED/96251036; Alexander P; Krishnamurthy VV; Prisbe EJ; Gilead Sciences, Inc., Foster City, California 94404, USA.; Pyranosyl nucleotide analogues have been designed so that the intramolecular base to phosphorus distance closely approximates that of natural nucleotides. This was achieved by attaching the phosphorus directly at the anomeric position and the base at the 4-position of the carbohydrate. A series of compounds incorporat
Thymopentin modulates Th1 and Th2 cytokine response and host survival in experimental injury.: J Surg Res. 1996 May;62(2):197-200. Unique Identifier : AIDSLINE MED/96218794; Braga M; Gianotti L; Gentilini O; Fortis C; Consogno G; Di Carlo V; Department of Surgery, Raffaele Hospital, University of Milan,; Italy.; OBJECTIVE: To investigate the impact of thymopentin (Thy) on mortality and in vivo cytokine release in an animal model of gut-derived sepsis which includes different combinations of allogeneic blood transfusion (T) and burn injury plus bacterial gavage (BG). DESIGN: Randomly controlled experiments. MATERIAL: Two hundr
Expression of Id2 and Id3 mRNA in human lymphocytes.: Leuk Res. 1995 Dec;19(12):989-96. Unique Identifier : AIDSLINE MED/96226053; Ishiguro A; Spirin K; Shiohara M; Tobler A; Norton JD; Rigolet M; Shimbo T; Koeffler HP; Department of Medicine, Cedars-Sinai Medical Center, UCLA School; of Medicine 90048, USA.; Helix-loop-helix (HLH) transcription factors are involved in cellular growth and differentiation. The Id (inhibitor of DNA binding and differentiation) HLH proteins, in a dominantly negative fashion, regulate transcriptional activities of basic HLH proteins. We examined by northern hybridization the expression of Id2
The severity classification system for acquired immunodeficiency syndrome hospitalizations. Association with survival after discharge and inpatient resource use.: Med Care. 1996 Feb;34(2):178-89. Unique Identifier : AIDSLINE MED/96223903; Friedman LA; Hidalgo J; Bartnyska LM; Turner BJ; Center for AIDS Services Planning, Maryland Department of Health; and Mental Hygiene, Baltimore, USA.; The Severity Classification for AIDS Hospitalizations (SCAH) was applied to a longitudinal person-based data set of Maryland adult residents diagnosed with acquired immunodeficiency syndrome (AIDS) between 1983 and 1989 to predict long-term survival. In contrast to other AIDS severity measures, SCAH can be applied to
Simplified hot start PCR.: Nature. 1996 May 30;381(6581):445-6. Unique Identifier : AIDSLINE MED/96217918; Birch DE
Japanese minister takes pay cut to atone for HIV contamination [news]: Nature. 1996 Jun 6;381(6582):460. Unique Identifier : AIDSLINE MED/96232397
Managing body-substance exposures.: Nursing. 1996 Jan;26(1):26-7. Unique Identifier : AIDSLINE MED/96227023; Garb JR
TATA-dependent repression of human immunodeficiency virus type-1 transcription by the adenovirus E1A 243R oncoprotein.: Oncogene. 1996 Feb 15;12(4):819-26. Unique Identifier : AIDSLINE MED/96197762; Tsang SX; Morris GF; Lu M; Morris CB; Department of Pathology and Laboratory Medicine, Tulane Cancer; Center, New Orleans, Louisiana 70112, USA.; Human adenovirus E1A oncoprotein activates or represses transcription from a variety of viral and cellular promoters by several complex mechanisms. The E1A products, 289R and 243R, have differential effects on transcription directed by the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR). Previou
Human immunodeficiency virus type 1 infection despite prior immunization with a recombinant envelope vaccine regimen.: Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):3972-7. Unique Identifier : AIDSLINE MED/96210576; McElrath MJ; Corey L; Greenberg PD; Matthews TJ; Montefiori DC; Rowen L; Hood L; Mullins JI; Department of Medicine, University of Washington School of; Medicine, Seattle 98195, USA.; With efforts underway to develop a preventive human immunodeficiency virus type 1 (HIV-1) vaccine, it remains unclear which immune responses are sufficient to protect against infection and whether prior HIV-1 immunity can alter the subsequent course of HIV-1 infection. We investigated these issues in the context of a
Immunologic basis of transplant-associated arteriosclerosis.: Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4051-6. Unique Identifier : AIDSLINE MED/96210591; Shi C; Lee WS; He Q; Zhang D; Fletcher DL Jr; Newell JB; Haber E; Cardiovascular Biology Laboratory, Harvard School of Public; Health, Boston, MA 02115, USA.; Although immunosuppressive therapy minimizes the risk of graft failure due to acute rejection, transplant-associated arteriosclerosis of the coronary arteries remains a significant obstacle to the long-term survival of heart transplant recipients. The participation of specific inflammatory cell types in the genesis of
Foamy virus reverse transcriptase is expressed independently from the Gag protein.: Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4137-41. Unique Identifier : AIDSLINE MED/96210606; Enssle J; Jordan I; Mauer B; Rethwilm A; Institut fur Virologie und Immunbiologie, Wurzburg, Germany.; In the foamy virus (FV) subgroup of retroviruses the pol genes are located in the +1 reading frame relative to the gag genes and possess potential ATG initiation codons in their 5 regions. This genome organization suggests either a + 1 ribosomal frameshift to generate a Gag-Pol fusion protein, similar to all other re
Prolactin increases CD4/CD8 cell ratio in thymus-grafted congenitally athymic nude mice.: Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4165-9. Unique Identifier : AIDSLINE MED/96210611; Gaufo GO; Diamond MC; Group in Endocrinology, University of California, Berkeley; 94720-3140, USA.; One distinctive effect on T-cell development was analyzed by selectively increasing serum prolactin (PRL) concentration in thymus-grafted congenitally athymic nude mice and by neutralizing PRL in suspension cultures of thymus from 1-day-old neonatal mice. Flow cytometric analysis of single-positive CD4+ and CD8+ cells
Plasmoviruses: nonviral/viral vectors for gene therapy.: Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4175-80. Unique Identifier : AIDSLINE MED/96210613; Noguiez-Hellin P; Meur MR; Salzmann JL; Klatzmann D; Genopoietic, Paris, France.; We have generated a chimeric gene transfer vector that combines the simplicity of plasmids with the infectivity and long-term expression of retroviruses. We replaced the env gene of a Moloney murine leukemia virus-derived provirus by a foreign gene, generating a plasmid that upon transfer to tumor cells generates noni
Stable triple helices formed by oligonucleotide N3'-->P5' phosphoramidates inhibit transcription elongation.: Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4365-9. Unique Identifier : AIDSLINE MED/96210649; Escude C; Giovannangeli C; Sun JS; Lloyd DH; Chen JK; Gryaznov SM; Garestier T; Helene C; Laboratoire de Biophysique, Museum National d'Histoire; Naturelle, Institut National de la Sante et de la Recherche; Medicale, Paris, France.; Oligonucleotide analogs with N3 -->P5 phosphoramidate linkages bind to the major groove of double-helical DNA at specific oligopurine.oligopyrimidine sequences. These triple-helical complexes are much more stable than those formed by oligonucleotides with natural phosphodiester linkages. Oligonucleotide phosphoramida
Kinetics of cytokine expression during primary human immunodeficiency virus type 1 infection.: Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4386-91. Unique Identifier : AIDSLINE MED/96210653; Graziosi C; Gantt KR; Vaccarezza M; Demarest JF; Daucher M; Saag MS; Shaw GM; Quinn TC; Cohen OJ; Welbon CC; Pantaleo G; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892-1876, USA.; In the present study, we have determined the kinetics of constitutive expression of a panel of cytokines [interleukin (IL) 2, IL-4, IL-6, IL-10, interferon gamma (IFN-gamma), and tumor necrosis factor alpha (TNF-alpha)] in sequential peripheral blood mononuclear cell samples from nine individuals with primary human im
Viral dynamics in hepatitis B virus infection.: Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4398-402. Unique Identifier : AIDSLINE MED/96210655; Nowak MA; Bonhoeffer S; Hill AM; Boehme R; Thomas HC; McDade H; Department of Zoology, University of Oxford, United Kingdom;; Treatment of chronic hepatitis B virus (HBV) infections with the reverse transcriptase inhibitor lamivudine leads to a rapid decline in plasma viremia and provides estimates for crucial kinetic constants of HBV replication. We find that in persistently infected patients, HBV particles are cleared from the plasma with
Synthesis and targeted delivery of an azidothymidine homodinucleotide conferring protection to macrophages against retroviral infection.: Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4403-8. Unique Identifier : AIDSLINE MED/96210656; Magnani M; Casabianca A; Fraternale A; Brandi G; Gessani S; Williams R; Giovine M; Damonte G; De Flora A; Benatti U; Institute of Biochemistry Giorgio Fomaini, Urbino, Italy.; The infectivity and replication of human (HIV-1), feline (FIV), and murine (LP-BM5) immunodeficiency viruses are all inhibited by several nucleoside analogues after intracellular conversion to their triphosphorylated derivatives. At the cellular level, the main problems in the use of these drugs concern their limited
Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathway.: Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4421-4. Unique Identifier : AIDSLINE MED/96210659; Fridell RA; Bogerd HP; Cullen BR; Howard Hughes Medical Institute, Duke University Medical Center,; Durham, NC 27710, USA.; The Rev protein of HIV-1 is essential for the nuclear export of incompletely spliced viral mRNAs. This action depends on the mutationally defined Rev activation domain, which both binds the nucleoporin-like human cellular cofactor Rab/hRIP and also functions as a nuclear export signal. Protein kinase inhibitor alpha (
Human immunodeficiency virus (HIV) type 2-mediated inhibition of HIV type 1: a new approach to gene therapy of HIV-infection.: Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4486-91. Unique Identifier : AIDSLINE MED/96210671; Arya SK; Gallo RC; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, MD 20892-4255, USA.; Human immunodeficiency virus (HIV) type 2, the second AIDS-associated human retrovirus, differs from HIV-1 in its natural history, infectivity, and pathogenicity, as well as in details of its genomic structure and molecular behavior. We report here that HIV-2 inhibits the replication of HIV-1 at the molecular level. T
HIV arthritis.: Radiol Clin North Am. 1996 Mar;34(2):450-3. Unique Identifier : AIDSLINE MED/96221223; Eustace SJ; Lan HH; Katz J; Aliabadi P; Department of Radiology and Musculoskeletal Radiology Section,; Boston University Medical Center and Boston City Hospital,; Massachusetts, USA.
Lymphocyte subset composition in peripheral blood from normal subjects may be influenced by both spleen size and plasma norepinephrine.: Scand J Clin Lab Invest. 1995 Nov;55(7):643-8. Unique Identifier : AIDSLINE MED/96187513; Knudsen JH; Court-Payen M; Kjaersgaard E; Christensen NJ; Department of Internal Medicine and Endocrinology, University of; Copenhagen, Herlev Hospital, Denmark.; The aim of the present study was twofold: (a) to confirm a previously observed negative relationship between plasma catecholamines and the percentage of natural killer (NK) cells in peripheral blood from resting human subjects, and (b) to examine the relationship between the size of the spleen and the composition of c
Intranasal inoculation of Bordetella bronchiseptica in mice induces long-lasting antibody and T-cell mediated immune responses.: Scand J Immunol. 1996 Feb;43(2):181-92. Unique Identifier : AIDSLINE MED/96228950; Gueirard P; Minoprio P; Guiso N; Laboratoire des Bordetella, Institut Pasteur, Paris, France.; Humoral and cellular immune responses were analysed in mice inoculated intranasally with Bordetella bronchiseptica. After infection, the number of bacteria that colonized the respiratory tract of the mice increased during the first day and decreased thereafter. Total IgG levels increased as early as 14 days after infe
Long-lasting immune response induced by recombinant bacillus Calmette-Guerin (BCG) secretion system.: Scand J Immunol. 1996 Feb;43(2):202-9. Unique Identifier : AIDSLINE MED/96228952; Wada N; Ohara N; Kameoka M; Nishino Y; Matsumoto S; Nishiyama T; Naito M; Yukitake H; Okada Y; Ikuta K; Yamada T; School of Dentistry, Nagasaki University, Nagasaki City, Japan.; The recombinant bacillus Calmette-Guerin (rBCG) secretion system utilizing an extracellular alpha antigen of Mycobacterium kansasii (alpha-K) was characterized biochemically and immunologically. The human immunodeficiency virus type 1 (HIV-1) p17gag B cell epitope fused to alpha-K was secreted in extremely large amoun
Enhanced T lymphocyte expression of LFA-1, ICAM-1, and the TNF receptor family member OX40 in HgCl2-induced systemic autoimmunity.: Scand J Immunol. 1996 May;43(5):507-18. Unique Identifier : AIDSLINE MED/96233691; Roos A; Claessen N; Weening JJ; Aten J; Department of Pathology, University of Amsterdam, The; Netherlands.; Injection of mercuric chloride into Brown Norway (BN) rats induces a T lymphocyte-dependent autoimmune syndrome. In order to investigate whether modification of adhesion and costimulatory molecules on T lymphocytes may be involved in early T lymphocyte activation by HgCl2, the auth
In vivo activation of T-cell induction into the primed phenotype and programmed cell death by staphylococcal enterotoxin B.: Scand J Immunol. 1996 May;43(5):545-50. Unique Identifier : AIDSLINE MED/96233696; Aroeira LS; Moreno MC; Martinez C; Department of Immunology and Oncology, Universidad Autonoma de; Madrid, Spain.; The authors demonstrate that SEB immunization activates V beta 8+ T cells and induces the acquisition of the primed phenotype as defined previously by low MEL-14 and high Pgp-1 expression. SEB-activated spleen CD4+ and CD8V beta 8+ T cells have different population dynamics and regulate the expression of MEL-14 and Pg
Characterization of autoantibodies to natural killer cells in HIV-infected patients.: Scand J Immunol. 1996 May;43(5):583-92. Unique Identifier : AIDSLINE MED/96233701; Muller C; Szangolies M; Kukel S; Kiehl M; Sorice M; Griggi T; Lenti L; Bauer R; University of Bonn, Department of Dermatology, Germany.; Natural killer (NK) cells in HIV-infected patients have a reduced ability to generate non-MHC restricted cytotoxicity to a variety of target cells. The authors investigated antibodies to NK cells in HIV-infected patients and evaluated effects of these antibodies to NK cell numbers and function. Antibodies to NK cells
Different percentages of peripheral blood gamma delta + T cells in healthy individuals from different areas of the world.: Scand J Immunol. 1996 May;43(5):593-6. Unique Identifier : AIDSLINE MED/96233702; Esin S; Shigematsu M; Nagai S; Eklund A; Wigzell H; Grunewald J; Microbiology and Tumorbiology Center, Karolinska Institute,; Stockholm, Sweden.; The frequency of gamma delta + T cells in the peripheral blood of 26 Turkish, 24 Swedish, 35 Japanese and 14 Asian (non-Japanese) healthy blood donors and healthy volunteers were investigated by flow cytometry. In the Turkish group, 9.3% (median value) of the CD3+ peripheral blood T cells expressed the gamma delta T
Immunological tolerance [letter]: Science. 1996 Jun 7;272(5267):1408. Unique Identifier : AIDSLINE MED/96234293; Blumberg N; Heal JM
SIV data raise concern on oral-sex risk [news; comment]: Science. 1996 Jun 7;272(5267):1421-2. Unique Identifier : AIDSLINE MED/96234298; Cohen J
Infection and AIDS in adult macaques after nontraumatic oral exposure to cell-free SIV [see comments]: Science. 1996 Jun 7;272(5267):1486-9. Unique Identifier : AIDSLINE MED/96234312; Baba TW; Trichel AM; An L; Liska V; Martin LN; Murphey-Corb M; Ruprecht RM; Division of Newborn Medicine, Department of Pediatrics, Tufts; University School of Medicine, Boston, MA 02111, USA.; Unprotected receptive anal intercourse is a well-recognized risk factor for infection with human immunodeficiency virus-type 1 (HIV-1). Isolated human case reports have implicated HIV-1 transmission by oral-genital exposure. Adult macaques exposed nontraumatically to cell-free simian immunodeficiency virus (SIV) throu
[Human T-cell lymphotrophic virus type I and T-cell lymphoma]: Tidsskr Nor Laegeforen. 1996 Jan 20;116(2):238-41. Unique Identifier : AIDSLINE MED/96229836; Loraas A; Lote K; Samdal HH; Beiske K; Langholm R; Onkologisk avdeling Det Norske Radiumhospital, Oslo.; Human T-cell lymphotropic virus type I is an oncogenic retrovirus, endemic in Southwestern Japan , the Caribbean, some parts of Africa and Central and South America. The virus is etiologically associated with adult T-cell leukemia/lymphoma and a myelopathy called tropical spastic par
Renal allograft rejection--in situ demonstration of cytotoxic intratubular cells.: Transplantation. 1996 May 27;61(10):1546-9. Unique Identifier : AIDSLINE MED/96224215; Robertson H; Wheeler J; Kirby JA; Morley AR; Department of Microbiology, The Medical School, University of; Newcastle upon Tyne, United Kingdom.; A nonisotopic in situ hybridization method to detect perforin mRNA was developed in cytospin preparations of IL-2-stimulated normal human lymphocytes and applied to formalin-fixed acutely rejected renal transplant material. Individual cells expressing perforin mRNA were localized in severely damaged tubular areas, and
Pancreaticobiliary manifestations of AIDS.: AJR Am J Roentgenol. 1996 Jun;166(6):1269-74. Unique Identifier : AIDSLINE MED/96222683; Miller FH; Gore RM; Nemcek AA Jr; Fitzgerald SW; Department of Radiology, Northwestern Memorial Hospital,; Northwestern University Medical School, Chicago, IL 60611, USA.; The pancreas and the biliary tract are frequent sites of infectious, Inflammatory, and neoplastic disease in patients with HIV infection. However, the symptoms of pancreaticobiliary involvement may be relatively mild so that the prevalence of these disorders is probably underestimated. An appreciation of the imaging f
Giant ulcers in the ileum and colon caused by cytomegalovirus in patients with AIDS.: AJR Am J Roentgenol. 1996 Jun;166(6):1275-6. Unique Identifier : AIDSLINE MED/96222684; Balthazar EJ; Martino JM; Department of Radiology, New York University Tisch Medical; Center, NY 10016, USA.
Toxoplasmosis of the corpus callosum: another butterfly.: AJR Am J Roentgenol. 1996 Jun;166(6):1280-1. Unique Identifier : AIDSLINE MED/96222686; Lee HJ; Williams R; Kalnin A; Wolansky L; Department of Radiology, University Hospital, University of; Medicine and Dentistry of New Jersey-New Jersey Medical School,; Newark 07103, USA.
Isolated renal mucormycosis in two patients with AIDS.: AJR Am J Roentgenol. 1996 Jun;166(6):1282-4. Unique Identifier : AIDSLINE MED/96222687; Pastor-Pons E; Martinez-Leon MI; Alvarez-Bustos G; Nogales-Cerrato J; Gomez-Pardal A; Ibanez-Martinez J; Radiology Department, Hospital Reginal Carlos Haya, Malaga,; Spain.
Primary esophageal lymphoma in AIDS presenting as a nonhealing esophageal ulcer.: Am J Gastroenterol. 1996 Mar;91(3):602-3. Unique Identifier : AIDSLINE MED/96209603; Chow DC; B1eikh SH; Eickhoff L; Soloway GN; Saul Z; Yale Affiliated Gastrointestinal Program, Department of Medicine,; Bridgeport Hospital, Connecticut USA.
Risk factors for non-Hodgkin's lymphomas in acquired immunodeficiency syndrome (AIDS).: Am J Epidemiol. 1996 Feb 15;143(4):374-9. Unique Identifier : AIDSLINE MED/96225621; Armenian HK; Hoover DR; Rubb S; Metz S; Martinez-Maza O; Chmiel J; Kingsley L; Saah A; Department of Epidemiology, Johns Hopkins University School of; Hygiene and Public Health, Baltimore, MD 21205, USA.; The possibility that an agent in addition to the human immunodeficiency virus (HIV) may contribute to the etiology of non-Hodgkin s lymphoma in persons with acquired immunodeficiency syndrome (AIDS) was studied using participants from the Multicenter AIDS Cohort Study (MACS) of hom
Predictors of mortality in the Amsterdam cohort of human immunodeficiency virus (HIV)-positive and HIV-negative drug users.: Am J Epidemiol. 1996 Feb 15;143(4):380-91. Unique Identifier : AIDSLINE MED/96225622; van Haastrecht HJ; van Ameijden EJ; van den Hoek JA; Mientjes GH; Bax JS; Coutinho RA; Municipal Health Service, Department of Public Health and; Environment, Amsterdam, Netherlands.; The impact of human immunodeficiency virus (HIV) infection and other risk factors on mortality was studied in a cohort of Dutch injection drug users and drug users who did not inject. Participants were recruited between 1985 and 1992 and followed up through 1993. Vital status was ascertained through repeat visit infor
Mechanism and rate of placental transfer of zalcitabine (2',3'-dideoxycytidine) in Macaca nemestrina.: Am J Obstet Gynecol. 1996 Mar;174(3):856-63. Unique Identifier : AIDSLINE MED/96203540; Tuntland T; Nosbisch C; Baughman WL; Massarella J; Unadkat JD; Department of Pharamceutics, School of Pharmacy, University of; Washington, Seattle 98195-7610, USA.; OBJECTIVE: Our purpose was to determine whether the ant-human immunodeficiency virus drug zalcitabine (2 ,3 -dideoxycytidine) is actively transferred across the placenta in the near-term Macaca nemestrina. STUDY DESIGN: Constant rate infusions of zalcitabine (1.31 microg/min/kg) and antipyrine (66.7 microg/min/kg) wer
Amphetamine use: return of an old scourge in a consultation psychiatry setting.: Am J Psychiatry. 1996 Jun;153(6):789-93. Unique Identifier : AIDSLINE MED/96233480; Baberg HT; Nelesen RA; Dimsdale JE; Department of Medical Psychology, University of Bochum, Germany.; OBJECTIVE: Recreational use of amphetamine and its analogues has increased considerably during the last decade. The aim of this study was to determine possible demographic characteristics of amphetamine users and nonusers who were seen in psychiatric consultations on inpatient medical and surgery wards. METHOD: The au
Injection drug use and risk of HIV transmission among homeless men with mental illness.: Am J Psychiatry. 1996 Jun;153(6):794-8. Unique Identifier : AIDSLINE MED/96233481; Susser E; Miller M; Valencia E; Colson P; Roche B; Conover S; HIV Center for Clinical and Behavioral Studies, New York State; Psychiatric Institute, NY 10032, USA.; OBJECTIVE: The high seroprevalence of HIV that has been reported among homeless individuals with mental illness indicates an urgent need to examine HIV risk behavior in this population. METHOD: Injection drug use and sexual behavior were assessed in comprehensive interviews with 218 homeless mentally ill men in a New
Nevirapine, zidovudine, and didanosine compared with zidovudine and didanosine in patients with HIV-1 infection. A randomized, double-blind, placebo-controlled trial. National Institute of Allergy and Infectious Diseases AIDS Clinical Trials Group Protocol 241 Investigators.: Ann Intern Med. 1996 Jun 15;124(12):1019-30. Unique Identifier : AIDSLINE MED/96233410; D'Aquila RT; Hughes MD; Johnson VA; Fischl MA; Sommadossi JP; Liou SH; Timpone J; Myers M; Basgoz N; Niu M; Hirsch MS; Infectious Disease Unit, Massachusetts General Hospital,; Charlestown 02129, USA.; OBJECTIVE: To study the addition of a third human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitor, nevirapine , to the combination of zidovudine and didanosine. DESIGN: A 48-week, randomized, double-blind, placebo-controlled trial
Survival in HIV-infected patients who have received zidovudine: comparison of combination therapy with sequential monotherapy and continued zidovudine monotherapy. Multicenter AIDS Cohort Study Group.: Ann Intern Med. 1996 Jun 15;124(12):1031-8. Unique Identifier : AIDSLINE MED/96233411; Graham NM; Hoover DR; Park LP; Stein DS; Phair JP; Mellors JW; Detels R; Saah AJ; Johns Hopkins University School of Hygiene and Public Health,; Department of Epidemiology, Baltimore, MD 21205, USA.; BACKGROUND: Among patients who begin receiving zidovudine during intermediate-stage human immunodeficiency virus (HIV) infection, it is unclear whether changing to combination therapy (adding didanosine or zalcitabine) or sequential monotherapy (changing to didanosine
The effect of high-dose saquinavir on viral load and CD4+ T-cell counts in HIV-infected patients [see comments]: Ann Intern Med. 1996 Jun 15;124(12):1039-50. Unique Identifier : AIDSLINE MED/96233412; Schapiro JM; Winters MA; Stewart F; Efron B; Norris J; Kozal MJ; Merigan TC; Division of Infectious Diseases, Stanford University School of; Medicine, CA 94305-5107, USA.; OBJECTIVE: To evaluate the efficacy and safety of high-dose therapy with the human immunodeficiency virus (HIV) protease inhibitor saquinavir and to establish the duration of the effect of this therapy. DESIGN: Open-label study. SETTING: Clinical research referral center. PATIENTS: 40 adults with human immunodeficienc
Protease inhibitors for HIV infection [editorial; comment]: Ann Intern Med. 1996 Jun 15;124(12):1086-8. Unique Identifier : AIDSLINE MED/96233419; Bartlett JG
Colonic bacillary angiomatosis.: Ann Intern Med. 1996 Apr 15;124(8):735-7. Unique Identifier : AIDSLINE MED/96213854; Huh YB; Rose S; Schoen RE; Hunt S; Whitcomb DC; Finkelstein S; University of Pittsburgh School of Medicine, Pennsylvania, USA.
Plasma cytokines, cytokine antagonists, and disease progression in African women infected with HIV-1.: Ann Intern Med. 1996 Apr 15;124(8):757-62. Unique Identifier : AIDSLINE MED/96213858; Thea DM; Porat R; Nagimbi K; Baangi M; St. Louis ME; Kaplan G; Dinarello CA; Keusch GT; New England Medical Center, Boston, Massachusetts, USA.; OBJECTIVES: To examine the relation of circulating cytokines and cytokine antagonists to the progression of human immunodeficiency virus type 1 (HIV-1) disease. DESIGN: Cross-sectional analysis. SETTING: An ambulatory acquired immunodeficiency syndrome (AIDS) research clinic in Kinshasa,
Nurse caring behaviors for persons with acquired immunodeficiency syndrome/human immunodeficiency virus.: Appl Nurs Res. 1996 Feb;9(1):18-23. Unique Identifier : AIDSLINE MED/96204217; Mullins IL; Auburn University School of Nursing, AL 36849, USA.; The purpose of this study was to identify nurse caring behaviors desired by patients with acquired immunodeficiency syndrome (AIDS) or human immunodeficiency virus (HIV) seropositive. Forty-six adults with either a diagnosis of AIDS or HIV-seropositive participated in the study. Subjects indicated treat me as an indiv
The human immunodeficiency virus and nephrology nursing: implications for infected clients.: ANNA J. 1995 Dec;22(6):557-62, 617. Unique Identifier : AIDSLINE MED/96232013; Bradley-Springer L; HIV infection is a chronic disease that can occur in conjunction with a variety of renal problems. When it does, nephrology nursing care is complicated by the interactive nature of dealing with two complex disease processes. Nephrology nurses already possess the skills needed to deal with this complexity, but may need
Personality disorders predict onset of Axis I disorders and impaired functioning among homosexual men with and at risk of HIV infection.: Arch Gen Psychiatry. 1996 Apr;53(4):350-7. Unique Identifier : AIDSLINE MED/96219935; Johnson JG; Williams JB; Goetz RR; Rabkin JG; Remien RH; Lipsitz JD; Gorman JM; Department of Psychiatry, Columbia University, New York, USA.; BACKGROUND: A longitudinal study was conducted to investigate whether personality disorders (PDs) increase risk for the development of future Axis I disorders and serious functional impairment among human immunodeficiency virus (HIV)-seropositive and HIV-seronegative homosexual men. METHOD: Baseline assessments of PDs
Envelope gene sequences of human T-lymphotropic virus type 1 in Taiwan.: Arch Virol. 1996;141(2):219-29. Unique Identifier : AIDSLINE MED/96195251; Lin MT; Chen YC; Chen PJ; Yang YC; Tang JL; Wu JM; Chuang SE; Yang CS; Department of Oncology, National Taiwan University Hospital,; Taipei.; Three major types of HTLV-1 had been proposed, the Melanesian type, the Zairian type, and the cosmopolitan type, which was further divided into subtypes A, B and C, according to the phylogenetic tree constructed from LTR sequences of current HTLV-isolates. In this study, the envelope gene sequences of HTLV-1 from 9 Ta
Sensitivity of HIV-1 to neutralization by antibodies against O-linked carbohydrate epitopes despite deletion of O-glycosylation signals in the V3 loop.: Arch Virol. 1996;141(2):291-300. Unique Identifier : AIDSLINE MED/96195257; Hansen JE; Jansson B; Gram GJ; Clausen H; Nielsen JO; Olofsson S; Laboratory for Infectious Diseases, Hvidovre Hospital, Hvidovre,; Denmark.; It has been suggested that threonine or serine residues in the V3 loop of HIV-1 gp120 are glycosylated with the short-chain O-linked oligosaccharides Tn or sialosyl-Tn that function as epitopes for broadly neutralizing carbohydrate specific antibodies. In this study we examined whether mutation of such threonine or se
Human T-cell lymphotropic virus types I and II infections in patients with leukaemia/lymphoma and in subjects with sexually transmitted diseases in Nigeria.: Arch Virol. 1996;141(2):345-55. Unique Identifier : AIDSLINE MED/96195261; Olaleye OD; Ekweozor CC; Li ZL; Opala IE; Sheng Z; Onyemenem TN; Rasheed S; Department of Virology, College of Medicine, University College; Hospital, Ibadan, Nigeria.; Serological assays that distinguish antibodies to human T-cell lymphotropic virus types I (HTLV-I) and type II (HTLV-II), and polymerase chain reaction (PCR) tests were used to investigate association of these two human retroviruses with several well-defined clinical conditions in Nig
The therapeutic potential of antisense oligonucleotides.: Bioessays. 1995 Dec;17(12):1055-63. Unique Identifier : AIDSLINE MED/96112767; Sharma HW; Narayanan R; Division of Oncology, Roche Research Center, Hoffmann-La Roche; Inc., Nutley, NJ 07110, USA.; Specific inhibition of gene expression by antisense agents provides the basis for rational drug discovery based on molecular targets. Due to the specificity of Watson-Crick base-pair hybridization, antisense oligodeoxynucleotides have been used extensively in attempts to inhibit gene expression in both in vitro and in
Recommending serologic HIV testing for the dental patient.: Am J Dent. 1995 Oct;8(5):263-6. Unique Identifier : AIDSLINE MED/96256551; Tilliss TS; Department of Dental Hygiene, University of Colorado School of; Dentistry, Denver 80262, USA.; This article provides information for dental clinicians to enable them to make appropriate recommendations to patients needing HIV antibody testing. Information concerning serologic tests for HIV, the decision to/not to test, characteristics of the compassionate HIV counselor, pre-test and posttest counseling are deta
Pain management and psychosocial issues in HIV and AIDS.: Am J Hosp Palliat Care. 1996 Jan-Feb;13(1):20-9. Unique Identifier : AIDSLINE MED/96232007; Breitbart W; My goal for this presentation is to provide an overview of the pain experience of patients with AIDS, including focuses on prevalence, common syndromes, and factors that contribute to undertreatment. As a means to dramatize the impact of pain on quality of life, we ll discuss excerpts from a videotape of one of my pat
Acquired immunodeficiency syndrome (AIDS)--data as at 15 December 1995.: Wkly Epidemiol Rec. 1995 Dec 15;70(50):353-4. Unique Identifier : AIDSLINE MED/96226918
The current global situation of the HIV/AIDS pandemic.: Wkly Epidemiol Rec. 1995 Dec 15;70(50):355. Unique Identifier : AIDSLINE MED/96226919
Provisional working estimates of adult HIV prevalence as of end 1994, by country.: Wkly Epidemiol Rec. 1995 Dec 15;70(50):355-7. Unique Identifier : AIDSLINE MED/96226920
Kissing-loop model of HIV-1 genome dimerization: HIV-1 RNAs can assume alternative dimeric forms, and all sequences upstream or downstream of hairpin 248-271 are dispensable for dimer formation.: Biochemistry. 1996 Feb 6;35(5):1589-98. Unique Identifier : AIDSLINE MED/96223652; Laughrea M; Jette L; McGill AIDS Centre, Lady Davis Institute for Medical Research,; Sir Mortimer B. Davis-Jewish General Hospital, Montreal,; Quebec, Canada.; The genome of all retroviruses consists of two identical RNAs noncovalently linked near their 5 end. Dimerization of genomic RNA is thought to modulate several steps in the retroviral life cycle, such as recombination, translation, and encapsidation. The kissing-loop model of HIV-1 genome dimerization [Laughrea, M.,
Zidovudine and dideoxynucleosides deplete wild-type mitochondrial DNA levels and increase deleted mitochondrial DNA levels in cultured Kearns-Sayre syndrome fibroblasts.: Biochim Biophys Acta. 1996 May 24;1316(1):51-9. Unique Identifier : AIDSLINE MED/96239825; Wang H; Lemire BD; Cass CE; Weiner JH; Michalak M; Penn AM; Fliegel L; Department of Biochemistry, University of Alberta, Edmonton,; Canada.; Kearns-Sayre syndrome is the most commonly diagnosed mitochondrial cytopathy and produces severe neuromuscular symptoms. The most frequent cause is a mitochondrial DNA deletion that removes a 4977-base pair segment of DNA that includes several genes encoding for respiratory chain subunits. Treatment of AIDS patients w
A robotics-based liquid chromatographic assay for the measurement of atovaquone in plasma.: J Pharm Biomed Anal. 1995 Oct;13(11):1383-93. Unique Identifier : AIDSLINE MED/96229404; Studenberg SD; Long JD; Woolf JH; Bruner CJ; Wilson D; Woolley JL; Division of Pharmacokinetics and Drug Metabolism, Wellcome; Research Laboratories, Research Triangle Park, NC 27709, USA.; A precise and specific robotics-based liquid chromatographic (LC) method for measuring atovaquone concentrations in plasma was developed and validated, and the method was compared with an existing manual LC method. The compound was isolated from plasma by liquid-liquid extraction, separated by reversed-phase LC, and q
Interferon treatment for chronic hepatitis C infection in hemophiliacs--influence of virus load, genotype, and liver pathology on response.: Blood. 1996 Mar 1;87(5):1704-9. Unique Identifier : AIDSLINE MED/96202491; Hanley JP; Jarvis LM; Andrew J; Dennis R; Hayes PC; Piris J; Lee R; Simmonds P; Ludlam CA; Department of Haematology, Royal Infirmary of Edinburgh,; Scotland.; In this study, we assessed the effectiveness of interferon treatment in 31 hemophiliacs with chronic hepatitis C virus (HCV) infection. Interferon alfa-2a (3 MU three times weekly) was administered for 6 months. Response was assessed by both serial alanine transaminase (ALT) and HCV RNA levels measured by a sensitive
Macrophage inflammatory protein-1alpha is induced by human immunodeficiency virus infection of monocyte-derived macrophages.: Blood. 1996 Mar 1;87(5):2011-9. Unique Identifier : AIDSLINE MED/96202528; Canque B; Rosenzwajg M; Gey A; Tartour E; Fridman WH; Gluckman JC; Laboratoire de Biologie et Genetique des Deficits; Immunitaires, faculte de Medecine and hopital de la; Pitie-Salpetriere, Paris, France.; Disparate findings have been reported as to whether human immunodeficiency virus (HIV) affects cytokine production by macrophages (MA). We investigated production of different cytokines and of macrophage inflammatory protein (MIP)-1alpha by HIV-1Ba-L- or HIV-1Ada-infected blood-derived MA. Relative to controls, only M
Consumer-based research: using focus groups as a method for evaluating quality of care.: J Nurs Care Qual. 1996 Apr;10(3):28-33. Unique Identifier : AIDSLINE MED/96213286; Beaudin CL; Pelletier LR; Department of Health Services, School of Public Health,; University of California at Los Angeles, USA.; In response to the consumer movement, health care organizations have become interested in obtaining feedback through face-to-face contacts with the people using their products and services. Focus groups are one qualitative research method of obtaining rich information within a social context. The article discusses the
Subacute sclerosing panencephalitis and acquired immunodeficiency syndrome: role of electroencephalography and magnetic resonance imaging.: J Neuroimaging. 1996 Apr;6(2):122-5. Unique Identifier : AIDSLINE MED/96205227; Koppel BS; Poon TP; Khandji A; Pavlakis SG; Pedley TA; Department of Neurology, New York Medical College, New York, USA.; Subacute sclerosing panencephalitis (SSPE) had largely disappeared from the United States because of nearly universal measles vaccination, but it has reemerged in children infected with human immunodeficiency virus (HIV). Two children with SSPE are described. The first was HIV positive
Chagasic granulomatous encephalitis in immunosuppressed patients. Computed tomography and magnetic resonance imaging findings.: J Neuroimaging. 1996 Apr;6(2):94-7. Unique Identifier : AIDSLINE MED/96205220; Di Lorenzo GA; Pagano MA; Taratuto AL; Garau ML; Meli FJ; Pomsztein MD; Neurological Unit Fernandez Hospital, Department of Neuroimaging,; Instituto de Investigaciones, Neurologicas Raul Carrea-FLENI,; Buenos Aires, Argentina.; American trypanosomiasis (Chagas disease), a zoonosis caused by Trypanosoma cruzi with a high incidence in Latin America, may induce an uncommon form of localized encephalitis termed chagoma, found in few immunocompromised patients. The computed tomography (CT) and magnetic resonance imaging (MRI) findings of brain c
Candida albicans mannan-specific, delayed hypersensitivity down-regulatory CD8+ cells are genetically restricted effectors and their production requires CD4 and I-A expression.: Int Arch Allergy Immunol. 1996 Apr;109(4):334-43. Unique Identifier : AIDSLINE MED/96220199; Li SP; Lee SI; Wang Y; Domer JE; Department of Microbiology and Immunology, Tulane University; School of Medicine, New Orleans, La., USA.; There is considerable controversy over the induction and activity of down-regulatory cells active in various antigen-specific and antigen-nonspecific systems. We have been studying the nature of such cells in a Candida albicans mannan (MAN)-specific system for some time and report here the requirements for CD4+ and I-
Newborn babies threatened with HIV testing [news]: BMJ. 1996 May 11;312(7040):1185. Unique Identifier : AIDSLINE MED/96214557; Roberts J
Albendazole chemotherapy for treatment of diarrhoea in patients with AIDS in Zambia: a randomised double blind controlled trial.: BMJ. 1996 May 11;312(7040):1187-91. Unique Identifier : AIDSLINE MED/96214560; Kelly P; Lungu F; Keane E; Baggaley R; Kazembe F; Pobee J; Farthing M; University Teaching Hospital, Lusaka, Zambia.; OBJECTIVE--To determine the value of short course, high dose albendazole chemotherapy in the treatment of persistent diarrhoea related to HIV in unselected patients in urban Zambia . DESIGN--A randomised double blind placebo controlled trial of albendazole 800 mg twice daily for two
Cause of AIDS [letter]: BMJ. 1996 May 11;312(7040):1231. Unique Identifier : AIDSLINE MED/96214599; Cook GC
Primary HIV-1 infection: a new medical emergency? [editorial]: BMJ. 1996 May 18;312(7041):1243-4. Unique Identifier : AIDSLINE MED/96225297; Jolles S; Kinloch de Loes S; Johnson MA; Janossy G
Disease in children with HIV infection in Abidjan. Authors should have emphasised lack of tuberculosis in HIV positive children [letter; comment]: BMJ. 1996 May 18;312(7041):1302-3. Unique Identifier : AIDSLINE MED/96225336; Gilks C
A randomized, controlled effectiveness trial of an AIDS prevention program for low-income African-American youths.: Arch Pediatr Adolesc Med. 1996 Apr;150(4):363-72. Unique Identifier : AIDSLINE MED/96241626; Stanton BF; Li X; Ricardo I; Galbraith J; Feigelman S; Kaljee L; Division of General Pediatrics, Department of Pediatrics,; University of Maryland Medical School, Baltimore, USA.; BACKGROUND: Some interventions to reduce the risk of the acquired immunodeficiency syndrome (AIDS) that target youths have resulted in short-term increases in self-reported condom use. However, long-term intervention effects have not been assessed. STUDY QUESTION: Can a theoretically and culturally based, AIDS-risk re
Rapid high-performance liquid chromatographic assay for atovaquone.: J Chromatogr B Biomed Appl. 1996 Jan 12;675(1):180-2. Unique Identifier : AIDSLINE MED/96220415; Hansson AG; Mitchell S; Jatlow P; Rainey PM; Department of Laboratory Medicine, Yale University School of; Medicine, New Haven, CT 06520-8035, USA.; A rapid high-performance liquid chromatography assay has been developed for the drug atovaquone, which is currently being used to treat Pneumocystis carinii pneumonia and Toxoplasma gondii encephalitis associated with the acquired immunodeficiency syndrome (AIDS). Protein is precipitated from plasma with acetonitrile-
Human and bovine tuberculosis--new threats from an old disease [editorial; comment]: Br Vet J. 1996 Jan;152(1):3-5. Unique Identifier : AIDSLINE MED/96214625; Grange JM
Regulated ribosomal frameshifting by an RNA-protein interaction.: RNA. 1996 Apr;2(4):316-23. Unique Identifier : AIDSLINE MED/96211454; Kollmus H; Hentze MW; Hauser H; Genetics of Eukaryotes, GBF Gesellschaft fur Biotechnologische; Forschung mbH, Braunschweig, Germany.; Ribosomal frameshifting is a translational mechanism used as an essential step in the replication cycle of retroviruses. Programmed frameshifting in retroviral translation involves two sequence elements: A heptanucleotide slippery sequence which induces a low basal level of frameshifting and a downstream RNA structure
The sad and tragic life of Typhoid Mary.: Can Med Assoc J. 1996 Mar 15;154(6):915-6. Unique Identifier : AIDSLINE MED/96258172; Brooks J; As society grapples with contemporary moral questions raised by the barring of HIV-infected people from jobs and even crossing some national borders, it is probably useful to re-examine the case of Typhoid Mary. The case of Mary Mallon shows how an earlier age resolved the conflict that arises when society s right to
Seeing medicine through opera glasses.: Can Med Assoc J. 1996 Mar 15;154(6):921-3. Unique Identifier : AIDSLINE MED/96258174; Mason RB; Few opera buffs stop to consider how the illnesses suffered by opera s great heroes and heroines mirrored the medical treatments and public attitudes of their time. A Toronto physician and his wife, an English professor and literary critic, have written a book exploring how opera presents illnesses such as tuberculosi
Understanding the relationship between relative and absolute risk.: Cancer. 1996 Jun 1;77(11):2193-9. Unique Identifier : AIDSLINE MED/96224881; Dupont WD; Plummer WD Jr; Department of Preventive Medicine, Vanderbilt University School; of Medicine, Nashville, Tennessee 37232-2637, USA.; BACKGROUND. Relative risks are the most common statistics used to quantify the risk of mortal or morbid outcomes associated with different patient groups and therapeutic interventions. However, absolute risks are of greater value of both patient and physician in making clinical decisions. METHODS. The relationship bet
Therapy of fungal meningitis.: Clin Neuropharmacol. 1995 Apr;18(2):95-112. Unique Identifier : AIDSLINE MED/96220337; Slavoski LA; Tunkel AR; Division of Infectious Diseases, Medical College of Pennsylvania,; Philadelphia, PA 19129, USA.; There has been an increase in recent years in the number of reported cases of meningitis and brain abscesses caused by fungi. This increase is due to the availability of better diagnostic techniques for fungal infections and the ever-increasing population of immunocompromised hosts (1,2). The patients most susceptible
Specific antitumor activity of tumor-infiltrating lymphocytes expanded first in a culture with both anti-CD3 monoclonal antibody and activated B cells and then in a culture with interleukin-2.: Cancer Immunol Immunother. 1995 Dec;41(6):339-47. Unique Identifier : AIDSLINE MED/96225877; Tamada K; Harada M; Okamoto T; Takenoyama M; Ito O; Matsuzaki G; Nomoto K; Department of Immunology, Kyushu University, Fukuoka, Japan.; In order to expand tumor-infiltrating lymphocytes (TIL) efficiently and in order to use them for immunotherapy, we utilized lipopolysaccharide-activated B cells (LPS blasts) as costimulatory-signal-providing cells in an in vitro culture system. TIL, prepared from subcutaneously inoculated B16 melanoma, failed to expan
Clonally expanded CD8 T cells in patients with polymyalgia rheumatica and giant cell arteritis.: Clin Immunol Immunopathol. 1996 Jun;79(3):263-70. Unique Identifier : AIDSLINE MED/96216539; Martinez-Taboada VM; Goronzy JJ; Weyand CM; Department of Medicine, Division of Rheumatology, Mayo Clinic and; Foundation, Rochester, Minnesota 55905, USA.; Giant cell arteritis (GCA) is a vasculitic entity which exclusively, affects individuals older than 50 years of age. Polymyalgia rheumatica (PMR) is a closely related condition which lacks clinically significant vasculitic lesions but shares with GCA the age dependence and the HLA association. To examine whether age-r
Tuberculosis in pregnancy: interactions, diagnosis, and management.: Clin Obstet Gynecol. 1996 Mar;39(1):120-42. Unique Identifier : AIDSLINE MED/96220940; Miller KS; Miller JM Jr; Respiratory Therapy Services Trident Regional Health System,; Charleston, South Carolina 29406, USA.
Consider anti-CMV therapy [letter]: Chest. 1996 Apr;109(4):1130-1. Unique Identifier : AIDSLINE MED/96211624; Hawley PH; Chan N; Russell JA; Montaner JS
Specfic binding of adenosine deaminase but not HIV-1 transactivator protein Tat to human CD26.: Exp Cell Res. 1996 May 25;225(1):102-11. Unique Identifier : AIDSLINE MED/96217775; Blanco J; Marie I; Callebaut C; Jacotot E; Krust B; Hovanessian AG; Unite de virologie et d'Immunologie Cellulaire, UA CNRS 1157,; Institut Pasteur, Paris Cedex, France.; Adenosine deaminase (ADA) and the HIV-1 transactivator protein Tat have been reported to bind to human CD26, also known as dipeptidyl peptidase IV (DPP IV). In order to demonstrate the specificity of such binding under native conditions of CD26, i.e., when expressed on the cell surface, we established murine cell line
Glycosylation and stability of mature HIV envelope glycoprotein conformation under various conditions.: FEBS Lett. 1996 Jan 29;379(2):171-6. Unique Identifier : AIDSLINE MED/96225964; Papandreou MJ; Idziorek T; Miquelis R; Fenouillet E; IFR Jean Roche, URA 1455, Faculte de Medecine Nord, Marseille,; France.; The role of the glycans of the mature human immunodeficiency virus (HIV) envelope (gp160) in its stability in various conditions was studied. gp160 conformation was monitored through its subsequent ability to bind [125I]CD4. Treatment of glycosylated (CHO+) gp160 with (i) sodium dodecyl sulfate (SDS) concentrations ab
Antioxidant and redox regulation of gene transcription.: FASEB J. 1996 May;10(7):709-20. Unique Identifier : AIDSLINE MED/96224181; Sen CK; Packer L; Department of Molecular and Cell Biology, University of; California at Berkeley, California 94720-3200, USA.; Reactive oxygen species (ROS) are implicated in the pathogenesis of a wide variety of human diseases. Recent evidence suggests that at moderately high concentrations, certain forms of ROS such as H202 may act as signal transduction messengers. To develop a better understanding of the exact mechanisms that underlie ROS
Frequency and distribution of herpesvirus-like DNA sequences (KSHV) in different stages of classic Kaposi's sarcoma and in normal tissues from an Italian population.: Int J Cancer. 1996 May 16;66(4):427-31. Unique Identifier : AIDSLINE MED/96213779; Luppi M; Barozzi P; Maiorana A; Collina G; Ferrari MG; Marasca R; Morselli M; Rossi E; Ceccherini-Nelli L; Torelli G; Department of Medical Sciences, Section of Haematology,; University of Modena, Italy.; The frequency and distribution of herpesvirus-like DNA sequences (KSHV) were investigated by PCR in the pathologic skin lesions of a series of 22 HIV-negative elderly patients with classic Kaposi s sarcoma (KS) from Italy , one of the few regions of the world where classic KS is prev
Novel HPV types present in oral papillomatous lesions from patients with HIV infection.: Int J Cancer. 1996 May 16;66(4):453-6. Unique Identifier : AIDSLINE MED/96213783; Volter C; He Y; Delius H; Roy-Burman A; Greenspan JS; Greenspan D; de Villiers EM; Division for Tumorvirus Characterizatiom, Deutsches; Krebsforschungszentrum, Heidelberg, Germany.; Patients infected with the human immunodeficiency virus (HIV) often develop multiple papillomatous lesions of the oral cavity. In the present study, a total of 67 biopsies from benign oral lesions were analyzed for the presence of human papillomavirus (HPV) DNA using Southern-blot hybridization in combination with a p
Inverse relationship of melanocyte differentiation antigen expression in melanoma tissues and CD8+ cytotoxic-T-cell responses: evidence for immunoselection of antigen-loss variants in vivo.: Int J Cancer. 1996 May 16;66(4):470-6. Unique Identifier : AIDSLINE MED/96213786; Jager E; Ringhoffer M; Karbach J; Arand M; Oesch F; Knuth A; II. Medizinische Klinik, Hamatologie--Onkologie, Krankenhaus; Nordwest, Frankfurt, Germany.; Antigenic peptides derived from differentiation antigens of the melanocyte lineage were recently identified in human melanomas as targets for MHC-restricted cytotoxic T lymphocytes (CTL). CTL directed against peptides derived from the Melan A/MART-1, tyrosinase and gp100/Pmel17 antigens can be detected in melanoma pat
Interconnection between organellar functions, development and drug resistance in the protozoan parasite, Toxoplasma gondii.: Int J Parasitol. 1995 Nov;25(11):1293-9. Unique Identifier : AIDSLINE MED/96229270; Tomavo S; Boothroyd JC; Department of Microbiology and Immunology, Stanford University; School of Medicine, CA 94305-5402, USA.; The protozoan parasite Toxoplasma gondii causes severe disease in animals and humans. In AIDS patients, for example, the encephalitis it produces is a major cause of death. Part of the very successful strategy adopted by the parasite centers on its ability to differentiate from the actively growing tachyzoite form to
Cytokines and immunological control of Eimeria spp.: Int J Parasitol. 1995 Nov;25(11):1331-51. Unique Identifier : AIDSLINE MED/96229273; Ovington KS; Alleva LM; Kerr EA; Division of Biochemistry and Molecular Biology, School of Life; Science, Faculty of Science, Australian National University,; Canberra, Australia.; Protozoan parasites belonging to the genus Eimeria cause considerable losses in livestock production in which stocking densities are high or environments restricted. The ability of hosts to mount immunological responses which limit parasite reproduction vary according to the particular species of Eimeria. Typically th
Low-dose splenic irradiation in human immunodeficiency virus-related immune thrombocytopenia [letter]: Int J Radiat Oncol Biol Phys. 1996 May 1;35(2):417-8. Unique Identifier : AIDSLINE MED/96228862; Giraud P; Soum F; Daly-Schveitzer N; Trille JA; Auvergnat JC; Massip P
The HIV-1 nef protein interferes with phosphatidylinositol 3-kinase activation 1.: J Biol Chem. 1996 Mar 22;271(12):6590-3. Unique Identifier : AIDSLINE MED/96215074; Graziani A; Galimi F; Medico E; Cottone E; Gramaglia D; Boccaccio C; Comoglio PM; Institute for Cancer Research and Treatment (IRCC), University of; Torino Medical School, 10126 Torino, Italy.; nef is a human immunodeficiency virus (HIV) gene encoding a 27-kDa myristoylated protein with structural features of a signal transducing molecule, but whose functions are largely unknown. We studied the interactions of Nef with the signal transduction pathways triggered by the platelet-derived growth factor (PDGF) re
Comparative studies on the substrate specificity of avian myeloblastosis virus proteinase and lentiviral proteinases.: J Biol Chem. 1996 Mar 22;271(12):6781-8. Unique Identifier : AIDSLINE MED/96215101; Tozser J; Bagossi P; Weber IT; Copeland TD; Oroszlan S; Department of Biochemistry, University Medical School of; Debrecen, H-4012 Debrecen, Hungary.; The retroviral proteinase (PR) seems to play crucial roles in the viral life cycle, therefore it is an attractive target for chemotherapy. Previously we studied the specificity of human immunodeficiency virus (HIV) type 1 and type 2 as well as equine infectious anemia virus PRs using oligopeptide substrates. Here a si
Hypothalamo-pituitary-adrenal function in human immunodeficiency virus-infected men.: J Clin Endocrinol Metab. 1996 Feb;81(2):791-6. Unique Identifier : AIDSLINE MED/96225557; Lortholary O; Christeff N; Casassus P; Thobie N; Veyssier P; Trogoff B; Torri O; Brauner M; Nunez EA; Guillevin L; Service de Medecine Interne, Hopital Avicenne, Universite; Paris-Nord, Bobigny, France.; We prospectively studied adrenal function in 51 human immunodeficiency virus-positive male patients, including heterosexuals, homosexuals, and iv drug users, classified according to 1987 CDC criteria as belonging to stages II/III or IVC. Basal serum concentrations of cortisol (F), progesterone (P4) and 17 alpha-hydrox
A femtomolar-acting neuroprotective peptide [see comments]: J Clin Invest. 1996 May 15;97(10):2299-307. Unique Identifier : AIDSLINE MED/96217593; Brenneman DE; Gozes I; Laboratory of Developmental Neurobiology, National Institute of; Child Health and Human Development, National Institutes of; Health, Bethesda, Maryland 20892-4480, USA.; A novel 14-amino acid peptide, with stress-protein-like sequences, exhibiting neuroprotection at unprecedented concentrations, is revealed. This peptide prevented neuronal cell death associated with the envelope protein (GP 120) from HIV, with excitotoxicity (N-methyl d-aspartate), with the beta amyloid peptide (putat
The impact of HIV testing on blood utilization in the intensive care unit in patients with gastrointestinal bleeding.: Intensive Care Med. 1995 Nov;21(11):933-6. Unique Identifier : AIDSLINE MED/96229257; Ravry ME; Paz HL; Department of Medicine, Hahnemann University, Philadelphia, PA; 10102-1192, USA.; OBJECTIVE: To determine whether the AIDS epidemic has influenced physician use of blood products in intensive care unit management of gastrointestinal hemorrhage. METHODS: Retrospective chart review of 148 patients with gastrointestinal hemorrhage admitted to the intensive care unit. Forty-eight patients were admitted
Oral glutamine to prevent chemotherapy induced stomatitis: a pilot study.: J Lab Clin Med. 1996 Feb;127(2):223-8. Unique Identifier : AIDSLINE MED/96223790; Skubitz KM; Anderson PM; Department of Medicine, University of Minnesota Medical School,; Minneapolis, USA.; Mucositis is a common toxicity of cancer chemotherapy. Glutamine appears to be the major energy source for intestinal epithelium, and animal studies have suggested that dietary supplementation with glutamine may protect the gut from both radiation and chemotherapy. Patients experiencing stomatitis after a course of ch
The polymerase chain reaction: a revolutionary new procedure for the laboratory diagnosis of infectious disease.: J Ky Med Assoc. 1996 Apr;94(4):148-52. Unique Identifier : AIDSLINE MED/96215509; Buck GE; Alliant Health System, Louisville, KY, USA.; The polymerase chain reaction (PCR) is a revolutionary new means of amplifying, ie, replicating, selected DNA sequences in vitro. This procedure is rapid, requiring approximately 5 hours for completion, and exquisitely sensitive. Studies have shown that as few as one microorganism can be detected. Thus, it has the pot
Use of polymerase chain reaction and quantitative antibody tests in children born to human immunodeficiency virus-1-infected mothers.: J Med Virol. 1995 Dec;47(4):330-5. Unique Identifier : AIDSLINE MED/96189510; Newell ML; Loveday C; Dunn D; Kaye S; Tedder R; Peckham C; De Maria A; Giaquinto C; Omenaca F; Canosa C; et al; European Collaborative Study Coordinating Centre, Department of; Epidemiology, Institute of Child Health, London, United Kingdom.; The diagnosis of human immunodeficiency virus (HIV) infection in children born to HIV-infected mothers is complicated by the presence of passively acquired maternal antibodies, and exclusion of infection in these infants remains problematic. The use of genome detection by polymerase chain reaction (PCR) amplification
Productive HIV-1 infection of human vascular endothelial cells requires cell proliferation and is stimulated by combined treatment with interleukin-1 beta plus tumor necrosis factor-alpha.: J Med Virol. 1995 Dec;47(4):355-63. Unique Identifier : AIDSLINE MED/96189514; Conaldi PG; Serra C; Dolei A; Basolo F; Falcone V; Mariani G; Speziale P; Toniolo A; Institute of Medicine and Public Health, University of Pavia,; Italy.; Vascular endothelial cells (EC) play a key role in viral tropism in vivo. Since conflicting reports have been published on the capability of HIV to infect EC in vitro, we analyzed some factors potentially capable of influencing the susceptibility of human umbilical vein endothelial cells (HUVEC) to HIV-1. Both primary
Preirradiation chemotherapy with cyclophosphamide, doxorubicin, vincristine, and dexamethasone for primary CNS lymphomas: initial report of radiation therapy oncology group protocol 88-06.: J Clin Oncol. 1996 Feb;14(2):556-64. Unique Identifier : AIDSLINE MED/96223415; Schultz C; Scott C; Sherman W; Donahue B; Fields J; Murray K; Fisher B; Abrams R; Meis-Kindblom J; Department of Radiation Oncology, Medical College of Wisconsin,; Milwaukee 53226, USA.; PURPOSE: This study was a prospective phase I/II trial performed by the Radiation Therapy Oncology Group (RTOG) to test the tolerance and efficacy of preirradiation cyclophosphamide, doxorubicin, vincristine, and dexamethasone (CHOD) chemotherapy followed by large-volume, high-dose brain radiation therapy (RT) for pat
Characterization of T lymphocyte clones derived from Porphyromonas gingivalis infected subjects.: J Periodontal Res. 1996 Jan;31(1):47-56. Unique Identifier : AIDSLINE MED/96198719; Gemmell E; Woodford V; Seymour GJ; Immunopathology Laboratory, Oral Biology and Pathology,; Department of Dentistry, University of Queensland, Australia.; Porphyromonas gingivalis plays a major role in the pathogenesis of periodontal disease, however some individuals with P. gingivalis infection do not experience periodontal breakdown. The aim of this study was to investigate the proliferative responses of two highly defined groups of subjects and to establish and chara
Postbereavement depressive mood and its prebereavement predictors in HIV+ and HIV- gay men.: J Pers Soc Psychol. 1996 Feb;70(2):336-48. Unique Identifier : AIDSLINE MED/96193403; Folkman S; Chesney M; Collette L; Boccellari A; Cooke M; Center of AIDS Prevention Studies, University of California, San; Francisco 94105, USA. folkman@quickmail.ucsf.edu; Prebereavement predictors of the course of postbereavement depressive mood were examined in 110 gay men who were their partner s caregiver until the partner s death of AIDS. In all, 37 HIV+ and 73 HIV- bereaved caregiving partners were assessed bimonthly throughout a 10-month period beginning 3 months before and endin
Personality disorder and sexual risk taking among homosexually active and heterosexually active men attending a genito-urinary medicine clinic.: J Psychosom Res. 1995 Oct;39(7):901-10. Unique Identifier : AIDSLINE MED/96229422; Ellis D; Collis I; King M; Academic Department of Psychiatry, Royal Free Hospital, London,; United Kingdom.; 61 homosexually active men and 57 heterosexually active men attending a genito-urinary medicine clinic were assessed for personality disorder and sexual risk taking. Of the homosexually active men, 23/61 (38%) were found to have personality disorders, as against 16/57 (28%) of the heterosexually active men. Multiple r
IgA and IgG antibodies to distinct serotypes of Mycobacterium avium in HIV seropositivity and AIDS.: J Med Microbiol. 1996 Mar;44(3):165-9. Unique Identifier : AIDSLINE MED/96208536; Hernandez-Munoz HE; Stanford JL; Department of Bacteriology, University College London Medical; School, UK.; IgA and IgG antibodies to cytoplasmic and secreted antigens of serotypes 4 and 8 of Mycobacterium avium and the percentage of agalactosyl immunoglobulin (%Gal[0]) were measured by ELISA in groups of blood donors, HIV seronegative persons, HIV seropositive persons with CD4+ cell counts >300/mm3 and AIDS patients co-inf
A comparison of the Genie and Western blot assays in confirmatory testing for HIV-1 antibody.: J Med Microbiol. 1996 Mar;44(3):223-5. Unique Identifier : AIDSLINE MED/96208546; Chan EL; Sidaway F; Horsman GB; Viral Serology Section, Department of Clinical Microbiology,; Saskatchewan Health, Canada.; The Genie HIV-1/2 kit (Sanofi Diagnostics Pasteur, Montreal, Quebec), a synthetic-peptide solid-phase enzyme immunoassay, was evaluated as a confirmatory assay for HIV-1 antibodies in comparison with Western blot (BioRad, Hercules, CA, USA) on 50 stored HIV-1 antibody-positive sera and the 137 sera yielding repeated p
Molecular genetic approaches to identification, epidemiology and taxonomy of non-albicans Candida species.: J Med Microbiol. 1996 Jun;44(6):399-408. Unique Identifier : AIDSLINE MED/96235983; Sullivan DJ; Henman MC; Moran GP; O'Neill LC; Bennett DE; Shanley DB; Coleman DC; University of Dublin, School of Dental Science, Department of; Oral Medicine and Pathology, Republic of Ireland.; The reported incidence of fungal infections associated with non-albicans species from the Candida genus is increasing. Most of these infections occur in immunocompromised patients, particularly those infected with HIV. The role of molecular genetic techniques alongside the existing techniques for the identification an
Flexible regions of RNA structure facilitate co-operative Rev assembly on the Rev-response element.: J Mol Biol. 1996 May 24;258(5):763-77. Unique Identifier : AIDSLINE MED/96221984; Zemmel RW; Kelley AC; Karn J; Butler PJ; MRC Laboratory of Molecular Biology, Cambridge, UK.; The oligomerisation of Rev on the Rev-response element (RRE) was studied using a series of model substrates. Only a monomer of Rev is able to bind efficiently to a high affinity site that is flanked by perfect duplex RNA. Addition of a bulge or a second stem structure adjacent to the high affinity site permits the co-
Thermodynamic prediction of conserved secondary structure: application to the RRE element of HIV, the tRNA-like element of CMV and the mRNA of prion protein.: J Mol Biol. 1996 May 24;258(5):813-26. Unique Identifier : AIDSLINE +; Luck R; Steger G; Riesner D; Institut fur Physikalische Biologie,; Heinrich-Heine-Universitat, Dusseldorf, FRG.; An algorithm for prediction of conserved secondary structure of single-stranded RNA is presented. For each RNA of a set of homologous RNAs optimal and suboptimal secondary structures are calculated and stored in a base-pair probability matrix. A multiple sequence alignment is performed for the set of RNAs. The resulti
Regarding Lower extremity lymphedema caused by acquired immune deficiency syndrome-related Kaposi's sarcoma [letter]: J Vasc Surg. 1996 Feb;23(2):378. Unique Identifier : AIDSLINE MED/96195187; Dougherty M; Calligaro KD; DeLaurentis DA
From the Centers for Disease Control and Prevention. AIDS associated with injecting-drug use--United States, 1995.: JAMA. 1996 Jun 5;275(21):1628-9. Unique Identifier : AIDSLINE MED/96245228
Primary adult T cell leukemia of bone: two patients with primary bone lesion showing monoclonal integration of HTLV-I proviral DNA.: Leukemia. 1996 Feb;10(2):333-7. Unique Identifier : AIDSLINE MED/96200145; Takemoto S; Matsuoka M; Sakata K; Matsuzaki H; Akagi K; Yamaguchi K; Takatsuki K; Second Department of Internal Medicine, Kumamoto University; School of Medicine, Japan.; Adult T cell leukemia (ATL), a neoplasm of mature helper T lymphocytes is etiologically associated with human T lymphotropic virus type-I (HTLV-I). ATL cells infiltrate various organs, the lung, skin, central nervous system, gastrointestinal tract, and bone, causing various clinical manifestations. Two unusual cases o
[Pleural cryptococcosis in patients with human immunodeficiency virus infection]: Med Clin (Barc). 1996 Mar 16;106(10):380-2. Unique Identifier : AIDSLINE MED/96219424; Mauri M; Fernandez Sola A; Capdevila JA; Ruiz I; Ribera E; Ocana I; Ferrer A; Pahissa A; Unitat de Malalties Infeccioses, Hospital General Vall d'Hebron,; Barcelona.; Four cases of pleural cryptococcosis as the form of onset of cryptococcosis in patients with human immunodeficiency virus (HIV) infection are reported. In two out of the four cases cryptococci were simultaneously isolated in other localizations (blood and meninges). In the two remaining patients the pleura was the onl
[The Oregon health care plan: beyond the experiment (letter)]: Med Clin (Barc). 1996 Mar 16;106(10):396. Unique Identifier : AIDSLINE MED/96219429; Abreu Galan MA
[News about HIV. Combination therapy with new drugs gives hope]: Lakartidningen. 1996 Feb 7;93(6):451-2. Unique Identifier : AIDSLINE MED/96248200; Sonnerborg A; Julander I; Infektionskliniken och avdelningen for klinisk virologi,; Huddinge sjukhus.
HIV epidemic in India: opportunity to learn from the past.: Lancet. 1996 May 18;347(9012):1349-50. Unique Identifier : AIDSLINE MED/96215986; Lalvani A; Shastri JS; Nuffield Department of Clinical Medicine, University of Oxford,; John Radcliffe Hospital, UK.
A cofactor for HIV-1 entry into cells is identified [news]: Lancet. 1996 May 18;347(9012):1395. Unique Identifier : AIDSLINE MED/96215998; Rowe PM
Longstanding presence in Belgians of multiple non-B HIV-1 subtypes [letter]: Lancet. 1996 May 18;347(9012):1403. Unique Identifier : AIDSLINE MED/96216006; Fransen K; Buve A; Nkengasong JN; Laga M; van der Groen G
CD4 lymphopenia and risk of infection in immunogerontologically healthy elderly people [letter]: Lancet. 1996 May 18;347(9012):1408. Unique Identifier : AIDSLINE MED/96216014; Ogata K; Tamura H; Yokose N; Dan K; Nomura T
Parasitism of HIV-infected patients by insect flagellates [letter]: Lancet. 1996 May 18;347(9012):1409. Unique Identifier : AIDSLINE MED/96216017; Dedet JP
Invasive pneumococcal disease in HIV-1 infected patients [letter]: Lancet. 1996 May 18;347(9012):1414. Unique Identifier : AIDSLINE MED/96216027; Domingo P; Puig M; Pericas R; Mirelis B; Prats G
Anterior pitutiary and pitutiary-dependent target organ function in men infected with the human immunodeficiency virus.: Metabolism. 1996 Jun;45(6):738-46. Unique Identifier : AIDSLINE MED/96224247; Wilson LD; Truong MP; Barber AR; Aoki TT; Department of Medicine, University of California, Davis, USA.; To evaluate pituitary and pituitary-dependent target organ function in men infected with the human immunodeficiency virus (HIV), 26 ambulatory HIV-positive men (13 with acquired immunodeficiency syndrome [AIDS]) and nine healthy control men were administered rapid sequential injections of thyrotropin (TSH)-releasing h
Common drug interactions in HIV medicine.: Med J Aust. 1996 May 20;164(10):605-6. Unique Identifier : AIDSLINE MED/96233608; Carey DL; Day RO; Bowden FJ; St Vincent's Hospital, Sydney, NSW.
Antiretroviral therapy.: Med J Aust. 1996 May 20;164(10):607. Unique Identifier : AIDSLINE MED/96233609; Fulcher D; Clezy K; Department of Immunopathology, Westmead Hospital, Sydney, NSW.; Initiating or changing antiretroviral therapy requires specialist knowledge of indications, side effects and drug interactions. This brief guide highlights the key points for monitoring antiretroviral therapy.
HIV and sexually transmitted diseases.: Med J Aust. 1996 May 20;164(10):608-11. Unique Identifier : AIDSLINE MED/96233610; Plummer DC; Furner V; National Centre for Epidemiology and Population Health,; Australian National University, Canberra.; Sexually transmitted diseases (STDs) play a key role in the AIDS epidemic. The transmission of HIV is amplified by some STDs, and HIV has been found to alter the natural history and prevalence of others. The control of STDs is fundamental to effective prevention and management of HIV infection.
HIV and palliative care.: Med J Aust. 1996 May 20;164(10):612-5. Unique Identifier : AIDSLINE MED/96233611; Glare PA; Cooney NJ; Department of Medical Oncology and Palliative Care, Westmead; Hospital, Sydney, NSW.; The goals of palliative care are the relief of pain and suffering in advanced disease and the support of the patient s carers. In HIV medicine, good palliative care often includes active treatment, and the palliative care team may work in support of the primary care doctor.
HIV and autopsies.: Med J Aust. 1996 May 20;164(10):616-7. Unique Identifier : AIDSLINE MED/96233612; Duflou J; Marriott D; New South Wales Institute of Forensic Medicine, Sydney, NSW.
The risk of transfusion-transmitted viral infections. The Retrovirus Epidemiology Donor Study [see comments]: N Engl J Med. 1996 Jun 27;334(26):1685-90. Unique Identifier : AIDSLINE MED/96240528; Schreiber GB; Busch MP; Kleinman SH; Korelitz JJ; Westat, Inc., Rockville, MD 20850, USA.; BACKGROUND: Accurate estimates of the risk of transfusion-transmitted infectious disease are essential for monitoring the safety of the blood supply and evaluating the potential effect of new screening tests. We estimated the risk of transmitting the human Immuno-deficiency virus (HIV), the human T-cell lymphotropic v
A reversible posterior leukoencephalopathy syndrome [letter]: N Engl J Med. 1996 Jun 27;334(26):1745; discussion 1746. Unique Identifier : AIDSLINE MED/96240543; Kahn JS; Romano S; Andiman WA
Massive infiltration of the skin by HIV-specific cytotoxic CD8+ T cells [letter]: N Engl J Med. 1996 Jul 4;335(1):61-2. Unique Identifier : AIDSLINE MED/96249148; Bachelez H; Hadida F; Gorochov G
Ministers seek legal shelter from Canada's HIV inquiry [news]: Nature. 1996 Mar 21;380(6571):188. Unique Identifier : AIDSLINE MED/96207740; Spurgeon D
Panel calls for overhaul of AIDS research [news]: Nature. 1996 Mar 21;380(6571):190. Unique Identifier : AIDSLINE MED/96207741; Wadman M
Pseudomonas aeruginosa pneumonia/sepsis as an initial opportunistic infection in an HIV patient.: Mil Med. 1996 Mar;161(3):179. Unique Identifier : AIDSLINE MED/96215536; Amundson DE; Mancini SA; Department of Critical Care, Naval Medical Center, San Diego, CA; 92134-5000, USA.
Results of a prospective evaluation of three methods of management of pediatric cataracts.: Ophthalmology. 1996 May;103(5):713-20. Unique Identifier : AIDSLINE MED/96221488; Basti S; Ravishankar U; Gupta S; Cornea Service, LV Prasad Eye Institute, Hyderabad, India.; BACKGROUND: Although a variety of approaches to manage cataracts in children have been studied, no consensus exists on the optimum approach. The authors, therefore, conducted a prospective, nonrandomized, consecutive study to evaluate three most commonly adopted methods of management of pediatric cataracts. METHODS: L
Analysis of chimeric Gag-Arg/Abl molecules indicates a distinct negative regulatory role for the Arg C-terminal domain.: Oncogene. 1996 Feb 1;12(3):631-40. Unique Identifier : AIDSLINE MED/96226098; Mysliwiec T; Perego R; Kruh GD; Department of Medical Oncology, Fox Chase Cancer Center,; Philadelphia, Pennsylvania 19111, USA.; Arg and c-Abl represent the mammalian member of the Abelson family of nonreceptor protein tyrosine kinases. The two proteins are composed of SH2, SH3, kinase and C-terminal domains. To examine Arg structure-function relationships we analysed a Gag-Arg fusion protein, analogous to the oncogenic Gag-Abl fusion protein o
Diagnostic imaging: its role in evaluating chest, abdominal, and musculoskeletal infections.: Postgrad Med. 1996 Mar;99(3):175-83. Unique Identifier : AIDSLINE MED/96209883; Stern EJ; Hunter JC; Nghiem HV; Lewis DH; Department of Radiology, Harborview Medical Center, Seattle, WA; 98104, USA. estern@u.washington.edu.; Imaging studies can provide essential information when infection is suspected. Chest radiography remains the best radiographic screening tool for intrathoracic infections. Computed tomographic (CT) scanning is preferred for evaluation of solid-organ abscesses, peritoneal abscesses, and associated malignant tumors or a
Assessment of fever in HIV-infected patients.: Postgrad Med. 1996 Mar;99(3):78-80, 87-9, 93-4 passim. Unique Identifier : AIDSLINE MED/96209878; Gleckman R; Czachor JS; Carney Hospital, Boston, MA 02124-5666, USA.; Fever is common among HIV-infected patients. Because it may signal a serious, potentially fatal underlying infection, a thorough investigation is merited. Where does evaluation begin and end? Drs Gleckman and Czachor discuss a diagnostic approach for primary care physicians that emphasizes rapid identification of the
Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex.: Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2505-10. Unique Identifier : AIDSLINE MED/96197343; Keen NJ; Gait MJ; Karn J; Medical Research Council Laboratory of Molecular Biology,; Cambridge, United Kingdom.; The human immunodeficiency virus type 1 transactivator protein, Tat, stimulates transcriptional elongation from the viral long terminal repeat. To test whether Tat associates directly with activated transcription complexes, we have used the lac repressor protein (LacR) to trap elongating RNA polymerases. The arrested
CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells.: Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2588-92. Unique Identifier : AIDSLINE MED/96197357; Zhou LJ; Tedder TF; Department of Immunology, Duke University Medical Center, Durham,; NC 27710, USA.; Dendritic cells are potent antigen-presenting cells that initiate primary immune responses. Although dendritic cells derive from bone marrow stem cells, the intermediate stages in their development remain unknown. In this study, plastic-adherent blood monocytes (CD14+, CD1a-) cultured for 7 days with granulocyte-monoc
Decline in working memory associated with HIV infection. HNRC Group.: Psychol Med. 1995 Nov;25(6):1221-32. Unique Identifier : AIDSLINE MED/96229496; Stout JC; Salmon DP; Butters N; Taylor M; Peavy G; Heindel WC; Delis DC; Ryan L; Atkinson JH; Chandler JL; et al; San Diego Veterans Affairs Medical Center, USA.; HIV infection has been associated with decline in a number of cognitive functions that are components of working memory . Thus, tests of working memory that require the interaction of these components may be particularly sensitive to cognitive dysfunction that arises from HIV infection. To assess this possibility, wo
Neuropsychological deficits in tests of executive function in asymptomatic and symptomatic HIV-1 seropositive men.: Psychol Med. 1995 Nov;25(6):1233-46. Unique Identifier : AIDSLINE MED/96229497; Sahakian BJ; Elliott R; Low N; Mehta M; Clark RT; Pozniak AL; Department of Psychiatry, University of Cambridge.; There has been much debate about the exact nature and time of onset of the cognitive impairments associated with infection by the human immunodeficiency virus type 1 (HIV-1). Studies to date have not reached consistent conclusions. The present study comprised 22 asymptomatic and 18 symptomatic HIV-1 seropositive men,
Free-hand technique with ordinary antisepsis in abdominal US-guided fine-needle punctures: three-year experience.: Radiology. 1996 Jun;199(3):721-3. Unique Identifier : AIDSLINE MED/96220533; Caturelli E; Giacobbe A; Facciorusso D; Villani MR; Squillante MM; Siena DA; Cellerino C; Andriulli A; Department of Gastroenterology, Ospedale Casa Sollievo della; Sofferenza, Instituto Ricovero e Cura a Carattere Scientifico,; Foggia, Italy.; PURPOSE: To evaluate the adequacy of ordinary antisepsis in ultrasound (US)-guided free-hand fine-needle puncture. MATERIALS AND METHODS: Diagnostic and therapeutic procedures (n = 573) were performed in 456 patients. No puncture attachments, sterile gloves, or drapes or covers were used. Before each procedure the tra
HIV-related metabolic abnormalities in the brain: depiction with proton MR spectroscopy with short echo times.: Radiology. 1996 Jun;199(3):805-10. Unique Identifier : AIDSLINE MED/96220547; Laubenberger J; Haussinger D; Bayer S; Thielemann S; Schneider B; Mundinger A; Hennig J; Langer M; Department of Diagnostic Radiology, Klinikum der; Albert-Ludwigs-Universitat, Freiburg, Germany.; PURPOSE: To analyze brain metabolite changes in human immunodeficiency virus (HIV)-positive neurologically asymptomatic patients and patients with acquired immunodeficiency syndrome (AIDS) dementia complex (ADC). MATERIALS AND METHODS: Twelve ADC patients, 11 HIV-positive asymptoma
AIDS office budget morass settled [news]: Science. 1996 Mar 1;271(5253):1221. Unique Identifier : AIDSLINE MED/96258147
Vaccine drought spurs NIAID plan to improve industry ties... [news]: Science. 1996 Mar 1;271(5253):1227-8. Unique Identifier : AIDSLINE MED/96239616; Cohen J
Investors sought for AIDS vaccine trials [news]: Science. 1996 Mar 1;271(5253):1237. Unique Identifier : AIDSLINE MED/96239621
Blocked Ras activation in anergic CD4+ T cells [see comments]: Science. 1996 Mar 1;271(5253):1276-8. Unique Identifier : AIDSLINE MED/96239626; Fields PE; Gajewski TF; Fitch FW; Ben May Institute, Department of Pathology, University of; Chicago, IL 60637, USA.; T cell anergy is a state of functional unresponsiveness characterized by the inability to produce interleukin-2 ( IL-2 ) upon T cell receptor stimulation. The mitogen-activated protein kinases ERK-1 and ERK-2 and the guanosine triphosphate-binding protein p21ras were fou
Enhanced fidelity of 3TC-selected mutant HIV-1 reverse transcriptase.: Science. 1996 Mar 1;271(5253):1282-5. Unique Identifier : AIDSLINE MED/96239628; Wainberg MA; Drosopoulos WC; Salomon H; Hsu M; Borkow G; Parniak M; Gu Z; Song Q; Manne J; Islam S; Castriota G; Prasad VR; McGill AIDS Centre, Jewish General Hospital, Montreal, Canada.; Monotherapy with (-)2 ,3 -dideoxy-3 -thiacytidine ( 3TC ) leads to the appearance of a drug-resistant variant of human immunodeficiency virus-type 1 (HIV-1) with the methionine-184 --> valine (M184V) substitution in the reverse transcriptase (RT). Despi
Somatic mutation of immunoglobulin V genes in vitro.: Science. 1996 Mar 1;271(5253):1285-9. Unique Identifier : AIDSLINE MED/96239629; Kallberg E; Jainandunsing S; Gray D; Leanderson T; Immunology Unit, Lund University, Sweden.; The molecular mechanism behind affinity maturation is the introduction of point mutations in immunoglobulin (Ig) V genes, followed by the selective proliferation of B cells expressing mutants with increased affinity for antigen. An in vitro culture system was developed in which somatic hypermutation of Ig V genes was
HIV-1 Langerhans' cell tropism associated with heterosexual transmission of HIV.: Science. 1996 Mar 1;271(5253):1291-3. Unique Identifier : AIDSLINE MED/96239631; Soto-Ramirez LE; Renjifo B; McLane MF; Marlink R; O'Hara C; Sutthent R; Wasi C; Vithayasai P; Vithayasai V; Apichartpiyakul C; Auewarakul P; Pena Cruz V; Chui DS; Osathanondh R; Mayer K; Lee TH; Essex M; Harvard AIDS Institute, Boston, MA 02115, USA.; Heterosexual transmission by vaginal intercourse accounts for most transmission of human immunodeficiency virus-type 1 (HIV-1) in Africa and Asia but is less important in the HIV-1 epidemics of the United States and Western Europe. Epithelial Langerhans cells (LCs) represent a possibl
Viral counts count in HIV infection [see comments]: Science. 1996 May 24;272(5265):1124-5. Unique Identifier : AIDSLINE MED/96216285; Ho DD; Aaron Diamond AIDS Research Center, The Rockefeller University,; New York, 10016, USA.
Prognosis in HIV-1 infection predicted by the quantity of virus in plasma [see comments]: Science. 1996 May 24;272(5265):1167-70. Unique Identifier : AIDSLINE MED/96216290; Mellors JW; Rinaldo CR Jr; Gupta P; White RM; Todd JA; Kingsley LA; Department of Medicine, School of Medicine, University of; Pittsburgh, 15213, USA.; The relation between viremia and clinical outcome in individuals infected with human immunodeficiency virus-type 1 (HIV-1) has important implications for therapeutic research and clinical care. HIV-1 RNA in plasma was quantified with a branched-DNA signal amplification assay as a measure of viral load in a cohort of 1
Mycobacterium avium-intracellulare complex pneumonia in a non-HIV-infected individual: an increasingly recognized disease.: South Med J. 1996 May;89(5):522-5. Unique Identifier : AIDSLINE MED/96211038; Asnis DS; Bresciani AR; Cohn M; Department of Internal Medicine, NY 11355, USA.; In the past, Mycobacterium avium complex (MAC) was considered a colonizing microbe in the immunocompetent host. Today it should be considered a potential pathogen. We present a case of MAC necrotizing pneumonia in a 27-year-old man who tested negatively for the human immunodeficiency virus, had no typical granulomas,
Ethics, AIDS, and the neurosurgeon [editorial]: Surg Neurol. 1996 Mar;45(3):299-300. Unique Identifier : AIDSLINE MED/96221340; Heifetz MD
[The AIDS epidemic in Norway--where did it go?]: Tidsskr Nor Laegeforen. 1996 Jan 30;116(3):382-6. Unique Identifier : AIDSLINE MED/96248223; Eskild A; Stigum H; Magnus P; Avdeling for samfunnsmedisin, Statens institutt for folkehelse,; Oslo.; The 1986 prognosis for the AIDS-epidemic in Norway has not been fulfilled. The epidemic has been far less extensive than anticipated. In 1986, little knowledge existed about the parameters that influence the spread of the human immunodeficiency virus (HIV): the prevalence of HIV, t
[Epidermodysplasia verruciformis, human Papillomavirus infection, genital epithelial neoplasia and possible immunodeficiency]: Ugeskr Laeger. 1996 Feb 12;158(7):923-4. Unique Identifier : AIDSLINE MED/96245295; Rossen K; Madsen H; Grunnet N; Amtssygehuset i Gentofte, patologisk-anatomisk institut,; Rigshospitalet, Kobenhavn.; Papilloma virus infections are common in patients with immune defect/suppression. We describe a case of regional localised epidermodysplasia verruciformis in combination with genital intraepithelial neoplasia, refractory anaemia, and impaired immunity as demonstrated by lymphopenia with reduced B-cell/T-cell ratio, bu
Lack of dichotomy between virus load of peripheral blood and lymph nodes during long-term simian immunodeficiency virus infection of African green monkeys.: Virology. 1996 May 15;219(2):367-75. Unique Identifier : AIDSLINE MED/96213506; Beer B; Scherer J; zur Megede J; Norley S; Baier M; Kurth R; Paul-Ehrlich-Institute Langen, Germany.; During the asymptomatic phase of human immunodeficiency virus 1 (HIV-1) infection the lymphatic tissues seem to function as a major reservoir of HIV. We have examined the viral load in peripheral blood mononuclear cells (PBMC) and lymph node mononuclear cells (LNMC) of 12 naturally and 4 experimentally long-term simia
Natural variation in HIV-1 protease, Gag p7 and p6, and protease cleavage sites within gag/pol polyproteins: amino acid substitutions in the absence of protease inhibitors in mothers and children infected by human immunodeficiency virus type 1.: Virology. 1996 May 15;219(2):407-16. Unique Identifier : AIDSLINE +; Barrie KA; Perez EE; Lamers SL; Farmerie WG; Dunn BM; Sleasman JW; Goodenow MM; Pathology, Immunology and Laboratory Medicine, University of; Florida College of Medicine Health Science Center, Gainesville; 32610, USA.; Reduced sensitivity of human immunodeficiency virus type 1 (HIV-1) to protease inhibitors is associated with multiple amino acid substitutions in the virus-encoded protease. The combination of changes that contribute to drug resistance is dependent in part upon the
Differential effects of intronic and exonic locations of the human immunodeficiency virus type 1 Rev-responsive element.: Virology. 1996 May 15;219(2):423-31. Unique Identifier : AIDSLINE MED/96213512; Campbell LH; Borg KT; Arrigo SJ; Department of Microbiology and Immunology, Medical University of; South Carolina, Charleston 29425-2230, USA.; The influence of the location of the Rev-response element (RRE) on human immunodeficiency virus type 1 (HIV-1) protein and RNA expression in COS cells was assessed. The RRE was placed into nef where it would be present in all HIV-1 RNAs. At this location, Gag and Env proteins were produced and the unspliced gag/pol an
Restriction of HIV-1 (subtype B) replication at the entry step in rhesus macaque cells.: Virology. 1996 May 15;219(2):485-8. Unique Identifier : AIDSLINE MED/96213520; Himathongkham S; Luciw PA; Department of Medical Pathology, University of California, Davis; 95616, USA.; Human immunodeficiency virus type 1 (HIV-1) is restricted for replication in rhesus macaque cells and does not establish infection in this species. The block to productive infection of macaque peripheral blood mononuclear cells (PBMC) in culture was investigated. A chimeric virus SHIV containing HIV-1 tat, rev, and en
[Cerebral toxoplasmosis in AIDS patients, CT and MRI images and differential diagnostic problems]: Acta Med Port. 1996 Jan;9(1):29-36. Unique Identifier : AIDSLINE MED/96224419; Miguel J; Champalimaud JL; Borges A; Chorao M; Branco G; Doroana M; Medina E; Servico de Neurorradiologia e Anatomia-Patologica, Hospital; Egas Moniz, Lisboa.; Cranial computed-tomographies (CT) and magnetic resonance imaging (MRI) of 14 patients with AIDS and central nervous system toxoplasmosis (CNST) were reviewed. In spite of the low specificity of CT and MRI findings in CNS mass lesions of AIDS patients, there are some features which have been observed as more typical o
HIV, Ebola virus and public health measures [letter]: Am Fam Physician. 1996 May 15;53(7):2283-4. Unique Identifier : AIDSLINE MED/96222744; Clarke P
AAP tuberculin testing recommendations [news]: Am Fam Physician. 1996 May 15;53(7):2378. Unique Identifier : AIDSLINE MED/96222754
Random suppression of T cells that bear specific T cell receptor V(beta) sequences in adult T cell leukemia/lymphoma (ATLL) patients at each clinical stage: carrier, smoldering, chronic, and acute.: Am J Hematol. 1996 May;52(1):1-7. Unique Identifier : AIDSLINE MED/96219901; Ohshima K; Suzumiya J; Kikuchi M; Takeshita M; Tashiro K; Kimura N; Department of Pathology, School of Medicine, Fukuoka University,; Japan.; Human T cell leukemia virus type I (HTLV-I) is associated with adult T cell leukemia/lymphoma (ATLL), which is well known as a T cell malignancy. In order to clarify whether HTLV-I plays a role as a virus-encoded superantigen in the neoplastic process, we examined the TCR V(beta) families in the peripheral blood at fo
Epstein-Barr virus infection and associated products (LMP, EBNA2, vIL-10) in nodal non-Hodgkin's lymphoma of human immunodeficiency virus-negative Japanese.: Am J Hematol. 1996 May;52(1):21-8. Unique Identifier : AIDSLINE MED/96219904; Ohshima K; Suzumiya J; Tasiro K; Mukai Y; Tanaka T; Kato A; Kikuchi M; Department of Pathology, School of Medicine, Fukuoka University,; Japan.; Sixty cases of B-cell nodal non-Hodgkin s malignant lymphoma (B-ML), and 46 cases of T-cell nodal lymphoma (T-ML) were surveyed for Epstein-Barr virus (EBV) genomes, RNA, and associated proteins. We used a Southern blot analysis, polymerase chain reaction (PCR), and EBV-encoded small RNA-1 (EBER-1) in situ hybridizati
Monoblastic leukemia in an HIV-infected patient: absence of viral expression in RNA blasts.: Am J Hematol. 1996 May;52(1):47-52. Unique Identifier : AIDSLINE MED/96219908; Guillemain C; George F; Courcoul M; Dhiver c; Brunet C; Spire B; Horschowski N; Conciatori M; Sampol J; Hematology Laboratory, CHU-Conception, Marseille, France.; A small number of patients seropositive for the human immunodeficiency virus (HIV) have been reported as developing acute non-lymphoblastic leukemia (ANLL). In the cases previously published, the authors never reported a study of the link joining HIV infection and leukemia. We describe here the case of a 41-year-old H
T-cell receptor J beta 1/J beta 2 locus rear