Importance of human immunodeficiency virus-associated lymphadenopathy and tuberculous lymphadenitis in patients undergoing lymph node biopsy in Zambia.

Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

Importance of human immunodeficiency virus-associated lymphadenopathy and tuberculous lymphadenitis in patients undergoing lymph node biopsy in Zambia.

Br J Surg. 1996 Jan;83(1):75-8. Unique Identifier : AIDSLINE MED/96264054
Bem C; Patil PS; Bharucha H; Namaambo K; Luo N; School of Medicine, University of Zambia, Republic of Zambia.

Abstract: The relative importance of human immunodeficiency virus (HIV)-associated lymphadenopathy amongst patients presenting for lymph node biopsy in Central Africa is unknown. HIV-1 serology and histology of patients undergoing superficial lymph node biopsy during 1989-1990 in Lusaka, Zambia, were examined in a prospective cohort study of HIV serology and by retrospective review of laboratory records. Of 727 lymph nodes biopsied in Lusaka in 1989-1990, 380 (52 per cent) showed tuberculous lymphadenitis, 160 (22 per cent) histology suggestive of primary HIV lymphadenopathy and 66 (9 per cent) nodal Kaposi's disease. HIV serology was tested in 280 adults and was positive in 91 per cent (255 patients), including 89 per cent (153 of 171) of those with tuberculous lymphadenitis, 98 per cent (63 of 64) of those with histology suspicious of primary HIV lymphadenopathy and all (24 of 24) with nodal Kaposi's disease. Other HIV-associated lymphadenopathy included nodal lymphomas and lymphoepithelial cysts. HIV serology was tested in 22 children and was positive in eight, including four of 14 with tuberculous lymphadenitis. It is concluded that HIV-associated lymphadenopathy, especially tuberculous lymphadenitis, is very common amongst patients presenting for lymph node biopsy in Central Africa.

Keywords: Adolescence Adult Age Distribution AIDS-Related Complex/COMPLICATIONS/*EPIDEMIOLOGY/PATHOLOGY AIDS-Related Opportunistic Infections/COMPLICATIONS/*EPIDEMIOLOGY/ PATHOLOGY Biopsy, Needle Child Child, Preschool Cohort Studies Female Human HIV Seropositivity Incidence Infant Infant, Newborn Male Middle Age Mycobacterium tuberculosis/ISOLATION & PURIF Retrospective Studies Sex Distribution Support, Non-U.S. Gov't Tuberculosis, Lymph Node/COMPLICATIONS/*EPIDEMIOLOGY/PATHOLOGY Zambia/EPIDEMIOLOGY JOURNAL ARTICLE
961030
M96A1395

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