1996

[Extra-pulmonary pneumocystosis in the course of AIDS. Report of a case]: Ann Pathol. 1996;16(1):41-4. Unique Identifier : AIDSLINE MED/96236528; Terris B; Marche C; Potet F; Service d'Anatomie et de Cytologie Pathologiques, Hopital; Bichat-Claude Bernard, Paris.; We report a case of splenic pneumocystosis in a human immunodeficiency virus-positive individual treated prophylactically with aerosolized pentamidine. Despite this infection with Pneumocystis carinii, the bronchoalveolar lavage revealed no microorganisms. The use of aerosolized pentamidine as prophylaxis for Pneumocy
Protective immunity against HIV infection: has nature done the experiment for us?: Immunol Today. 1996 Jan;17(1):21-4. Unique Identifier : AIDSLINE MED/96226679; Shearer GM; Clerici M; National Cancer Institute, Bethesda, MD 20892, USA.; Shearerg@dc10a.nci.nih.gov
Soluble HIV-suppressive factor.: Immunol Today. 1996 Jan;17(1):3. Unique Identifier : AIDSLINE MED/96226672
Molecular mimicry: CLIP, MHC Class II supermotifs and MAIDS [letter]: Immunol Today. 1996 Jan;17(1):47-8. Unique Identifier : AIDSLINE MED/96226684; Morse HC 3rd
Ceramide, AIDS and long-term survivors [letter; comment]: Immunol Today. 1996 Jan;17(1):48. Unique Identifier : AIDSLINE MED/96226685; De Simone C; Grazia Cifone M; Roncaioli P; Moretti S; Famularo G; Alesse E; Boschini A; Testi R
Circularizing ribozymes and decoy-competitors by autocatalytic splicing in vitro and in vivo.: SAAS Bull Biochem Biotechnol. 1996;9:77-82. Unique Identifier : AIDSLINE MED/96261112; Puttaraju M; Been MD; Department of Biochemistry, Duke University Medical Center,; Durham, NC-27710, USA.; An Anabaena group I intron was circularly permuted at loop 5, loop 6 and loop 8, and tested for self-splicing activity. Precursor RNAs from these constructs spliced efficiently and produced circular exons in vitro. Using group I permuted-intron-exon sequences, circular forms of the HDV ribozyme, the RNA component of R
Biological mechanisms of HIV sexual transmission [editorial]: Ann Med. 1995 Dec;27(6):621-3. Unique Identifier : AIDSLINE MED/96262747; Milman G
HIV-1 RNA in blood and pathogenesis of HIV infection [editorial]: Ann Med. 1995 Dec;27(6):625-8. Unique Identifier : AIDSLINE MED/96262748; Saksela K
Asymptomatic atherosclerosis in HIV-positive patients: A case-control ultrasound study.: Ann Med. 1995 Dec;27(6):683-5. Unique Identifier : AIDSLINE MED/96262757; Constans J; Marchand JM; Conri C; Peuchant E; Seigneur M; Rispal P; Lasseur C; Pellegrin JL; Leng B; Service de Medecine Interne et Pathologie Vasculaire, Hopital; Saint-Andre, Bordeaux, France.; Atherosclerosis has been reported in some HIV-positive subjects without any known risk factor. The purpose of the present study was to investigate cervical arteries, abdominal aorta and femoral arteries by B-mode ultrasonography and doppler in 30 HIV-positive subjects matched to 18 controls for sex, age, tobacco consu
Cyclosporin A attenuates genetic airway hyperresponsiveness in mice but not through inhibition of CD4+ or CD8+ T cells.: Am J Respir Cell Mol Biol. 1996 Jun;14(6):627-34. Unique Identifier : AIDSLINE MED/96258776; Ewart SL; Gavett SH; Margolick J; Wills-Karp M; Department of Anesthesiology, Johns Hopkins Medical Institutions,; Baltimore, Maryland, USA.; We examined the influence of T lymphocytes on genetically determined airway hyperresponsiveness to acetylcholine (ACh) in mice. A/J and C3H/HeJ mice were treated with the T-cell suppressant cyclosporin A [(CsA) 25 to 100 mg/kg, intraperitoneally (i.p.), for 5 to 10 days], whereas control animals received the vehicle o
[Movement disorders and AIDS]: Neurologia. 1996 Feb;11(2):70-5. Unique Identifier : AIDSLINE MED/96221732; Iranzo A; Kulisevsky J; Cadafalch J; Serrano C; Grau JM; Servicio de Neurologia, Hospital de la Santa Creu i Sant Pau,; Barcelona.; We describe the clinical characteristics, causes and response to treatment in 6 patients with AIDS who presented with abnormal movement disorders between January 1987 and July 1993 in our hospital, 3 with hemiballismus-hemichorea, 1 with athetosis, 1 myoclonia and 1 with rubric tremor. Brain imaging showed lesions in
Health care and its costs for children with perinatally acquired HIV infection.: J Paediatr Child Health. 1996 Feb;32(1):42-7. Unique Identifier : AIDSLINE MED/96241664; Carlin JB; Langdon P; Hurley SF; Ziegler JB; Doherty R; Chondros P; Kaldor JM; Clinical Epidemiology and Biostatistics Unit, Royal Children's; Hospital, Parkville, Victoria, Australia.; OBJECTIVE: To describe survival patterns, use of health services and related costs for Australian children with perinatally acquired human immunodeficiency virus (HIV) infection. METHODOLOGY: A retrospective cross-sectional survey was made of 20 children with HIV infection (91% of those diagnosed) and 13 children with
The mysterious Florida AIDS mystery [letter; comment]: Br Dent J. 1996 May 25;180(10):367. Unique Identifier : AIDSLINE MED/96266740; Lim M
Sexual behaviour and condom acceptance among Nigerian drivers.: West Afr J Med. 1996 Jan-Mar;15(1):6-10. Unique Identifier : AIDSLINE MED/96250994; Araoye MO; Onile BA; Jolayemi ET; Department of Epidemiology, University of Ilorin, Nigeria.; A survey of 180 randomly selected drivers was carried out in June 1994 in Ilorin, Nigeria in order to gain information about high-risk sexual behaviours, to ascertain condom use and to identify obstacles to condom acceptance so as to facilitate the design of an intervention to pre
[Significance of PUVA therapy for adult T-cell leukemia/lymphoma--PUVA therapy can induce apoptosis in leukemic cells]: Hum Cell. 1995 Sep;8(3):121-6. Unique Identifier : AIDSLINE MED/96111291; Takemori N; Hirai K; Department of Internal Medicine, Asahikawa Kosei General; Hospital, Japan.; PUVA therapy is known to be effective for treating cutaneous T-cell lymphoma (CTCL). Considering that adult T-cell leukemia/lymphoma (ATL) represents a T-lymphocytic proliferative disorder similar to CTCL, it is likely that PUVA therapy is effective for treating ATL. We applied PUVA therapy to a 53 year old man with a
Role of methionine 184 of human immunodeficiency virus type-1 reverse transcriptase in the polymerase function and fidelity of DNA synthesis.: Biochemistry. 1996 Feb 20;35(7):2168-79. Unique Identifier : AIDSLINE MED/96194137; Pandey VN; Kaushik N; Rege N; Sarafianos SG; Yadav PN; Modak MJ; Department of Biochemistry and Molecular Biology, UMD-New Jersey; Medical School, Newark 07103, USA.; Methionine 184 of HIV-1 RT is a constituent of the catalytically crucial and highly conserved YXDD motif in the reverse transcriptase class of enzymes. We investigated the role of this residue by substituting it with Ala and Val by site-directed mutagenesis followed by extensive characterization of the two mutant enzy
Arginine-binding RNAs resembling TAR identified by in vitro selection.: Biochemistry. 1996 Feb 20;35(7):2229-38. Unique Identifier : AIDSLINE MED/96194143; Tao J; Frankel AD; Department of Biochemistry and Biophysics, University of; California, San Francisco 94143-0448, USA.; Specific binding of the human immunodeficiency virus Tat protein to its RNA site (TAR) is mediated largely by a single arginine residue located within a basic region of the protein. Many essential features of the interaction can be mimicked by the free amino acid arginine, and an NMR model has been proposed in which t
Regulation of HIV-1 protease activity through cysteine modification.: Biochemistry. 1996 Feb 20;35(7):2482-8. Unique Identifier : AIDSLINE MED/96194171; Davis DA; Dorsey K; Wingfield PT; Stahl SJ; Kaufman J; Fales HM; Levine RL; Laboratory of Biochemistry, National Heart, Lung, and Blood; Institute, National Institutes of Health, Bethesda, Maryland; 20892-0320, USA.; The homodimeric protease of the human immunodeficiency virus 1 contains two cysteine residues per monomer which are highly conserved among viral isolates. However, these cysteine residues are not essential for catalytic activity which raises the question of why they are conserved. We have found previously that these c
Socio-economic and demographic characteristics and HIV-1 infection among female commercial sex workers in Thailand.: AIDS Care. 1995;7(5):557-65. Unique Identifier : AIDSLINE MED/96263762; van Griensven GJ; Limanonda B; Chongwatana N; Tirasawat P; Coutinho RA; Department of Public Health, Municipal Health Service, Amsterdam,; Netherlands.; To identify socio-economic and demographic factors related to prevalent HIV-1 infection among female commercial sex workers (CSW) in Thailand oral interviews and blood samples were taken from 800 female commercial sex workers in northern and southern Thailand during a cross-secti
Sexual risk behaviour reduction associated with voluntary HIV counselling and testing in HIV infected patients in Thailand.: AIDS Care. 1995;7(5):567-72. Unique Identifier : AIDSLINE MED/96263763; Muller O; Sarangbin S; Ruxrungtham K; Sittitrai W; Phanuphak P; Department of Social Medicine and Epidemiology, University of; Hannover, Germany.; Sexual risk behaviour, measured by anonymously self-reported sexual activity, number of sexual partners, and condom use rates, was studied in age- and gender-matched HIV-1 positive consecutive patients from the Thai Red Cross Immune Clinic (IC) (study group, questioned after voluntary HIV counselling and testing) and
AIDS awareness among a cohort of young Thai men: exposure to information, level of knowledge, and perception of risk.: AIDS Care. 1995;7(5):573-91. Unique Identifier : AIDSLINE MED/96263764; Sweat MD; Nopkesorn T; Mastro TD; Sangkharomya S; MacQueen K; Pokapanichwong W; Sawaengdee Y; Weniger BG; Division of HIV/AIDS, National Center for Infectious Diseases,; USA.; Structured interviews and focus group discussions were conducted among 834 young Thai men drafted into military service by random lottery in northern Thailand . Level of AIDS risk, exposure to AIDS information, level of knowledge about AIDS, and perception of risk for acquiring HI
Two HIV/AIDS community support teams: patient characteristics, problems at referral and during the last 6 weeks of life.: AIDS Care. 1995;7(5):593-603. Unique Identifier : AIDSLINE MED/96263765; Butters E; Higginson I; Department of Public Health and Policy, London School of Hygiene,; UK.; Following the debate over the role and funding of specialist HIV/AIDS services there has been a call for more information about the needs of people with advanced HIV/AIDS and the processes and outcomes of care. This study describes the characteristics and problems of patients referred to two HIV/AIDS community teams i
Psychological distress among gay men supporting a lover or partner with AIDS: a pilot study.: AIDS Care. 1995;7(5):605-17. Unique Identifier : AIDSLINE MED/96263766; Irving G; Bor R; Catalan J; Department of Psychology, University of Surrey, Guildford, UK.; To date, there has been little research to examine how much psychological distress is caused to people providing care and support to a lover or partner with AIDS. This study aimed to determine the level of psychological distress experienced by a sample of gay men providing care and support to a lover or partner with A
Gay men's accounts of unsafe sex.: AIDS Care. 1995;7(5):619-30. Unique Identifier : AIDSLINE MED/96263767; Boulton M; McLean J; Fitzpatrick R; Hart G; Academic Department of Public Health, St Mary's Hospital Medical; School, London, UK.; This paper provides a qualitative analysis of the explanations given by a sample of 78 gay men in England of the most recent occasion on which they engaged in anal intercourse without a condom. Explanations are analysed and interpreted from the sociological perspective of accounts : that is, they are not viewed as ex
Heterosexually acquired HIV infection in female blood donors: case series between 1985-1990.: AIDS Care. 1995;7(5):631-8. Unique Identifier : AIDSLINE MED/96263768; McLaws ML; Learmont J; Wylie B; School of Health Services Management, University of New South; Wales, Sydney, Australia.; The case histories aimed to describe the risk behaviours of a series of seven Australian women who acquired the human immunodeficiency virus (HIV) through heterosexual contact. Between 1985 and 1990 eight HIV antibody positive female donors were identified through routine HIV antibody screening at the NSW Red Cross Bl
The vaginal use of herbs/substances: an HIV transmission facilitatory factor?: AIDS Care. 1995;7(5):639-45. Unique Identifier : AIDSLINE MED/96263769; Runganga AO; Kasule J; Obstetric & Gynaecology Department, University of Zimbabwe,; Harare, Zimbabwe.; Heterosexual intercourse accounts for 80% of HIV transmission in sub-Saharan Africa. Factors facilitating cross-infection may include sexual practices such as the vaginal use of herbs/substances to dry, contract and heat the vagina for enhancement of sexual pleasure. The behavioural-analytic study investigated the use
Determinants of HIV risk among men who have homosexual sex and inject drugs.: AIDS Care. 1995;7(5):647-55. Unique Identifier : AIDSLINE MED/96263770; Crofts N; Marcus L; Meade J; Sattler G; Wallace J; Sharp R; Macfarlane Burnet Centre for Medical Research, Fairfield,; Victoria, Australia.; Men with histories of both homosexual contact and injecting drug use (IDU) are at increased risk of HIV infection over men who have only one such risk. Despite this, their special needs and circumstances have been neglected by AIDS prevention programmes. A survey of a wide spectrum of homosexual male IDUs was carried
Vertical transmission of HIV--a rediscussion of testing.: AIDS Care. 1995;7(5):657-62. Unique Identifier : AIDSLINE MED/96263771; Macquart-Moulin G; Hairion D; Auquier P; Manuel C; INSERM Research Unit, Institut Paoli-Calmettes, Marseille,; France.; It is worthwhile reconsidering the debate on mandatory or voluntary testing for HIV antibody among women of childbearing age, in the light of recent virological and therapeutic discoveries that have altered the parameters of the issue. The therapeutic possibilities of reducing the risk of transmission for women confir
Developing AIDS care in Zimbabwe: a case for residential community centres?: AIDS Care. 1995;7(5):663-73. Unique Identifier : AIDSLINE MED/96263772; Jackson H; Kerkhoven R; Southern Africa AIDS Information Dissemination Service, Harare,; Zimbabwe.; New support services are needed as the AIDS epidemic escalates. Home care has been the cornerstone of new developments in Zimbabwe and the southern African region, essentially resource-strapped countries. However, while home care has many benefits, levels of coverage are often lo
WHO global AIDS statistics. AIDS cases reported to the World Health Organization as at 7 July 1995.: AIDS Care. 1995;7(5):689-90. Unique Identifier : AIDSLINE MED/96263773
Oral ganciclovir: a new option for patients with CMV retinitis [editorial]: Int J STD AIDS. 1996 Jan-Feb;7(1):1-3. Unique Identifier : AIDSLINE MED/96228416; Fisher M; Barton S; Cytomegalovirus retinitis is a major cause of morbidity in patients with AIDS. The conventional treatment approach has involved insertion of a central venous catheter and intravenous administration of ganciclovir and/or foscarnet. This has been associated with systemic toxicity, line-related sepsis, and implications f
Vulval intraepithelial neoplasia [editorial]: Int J STD AIDS. 1996 Jan-Feb;7(1):10-3. Unique Identifier : AIDSLINE MED/96228419; Jebakumar S; Woolley PD; Bhattacharyya MN
Uses and limitations of gonococcal serotyping [editorial]: Int J STD AIDS. 1996 Jan-Feb;7(1):14-8. Unique Identifier : AIDSLINE MED/96228420; Ross JD
Tests for infection with Chlamydia trachomatis.: Int J STD AIDS. 1996 Jan-Feb;7(1):19-25; quiz 26. Unique Identifier : AIDSLINE MED/96228421; Taylor-Robinson D; Department of Genitourinary Medicine, St Mary's Hospital,; Paddington, London, UK.
The radiological manifestations of the acquired immune deficiency syndrome--Part 1.: Int J STD AIDS. 1996 Jan-Feb;7(1):27-31. Unique Identifier : AIDSLINE MED/96228422; Banerjee AK; Birmingham Heartlands Hospital (Teaching), Bordesley Green East,; UK.
Case-control study of sexually transmitted diseases as cofactors for HIV-1 transmission.: Int J STD AIDS. 1996 Jan-Feb;7(1):34-8. Unique Identifier : AIDSLINE MED/96228423; Beck EJ; Mandalia S; Leonard K; Griffith RJ; Harris JR; Miller DL; Academic Department of Public Health, St Mary's Hospital and; Medical School, London, UK.; The aim of the study was to investigate the association between infection with HIV-1 infection and a history of other sexually transmitted diseases (STD). We were able to match 1295 HIV-1 infected patients who attended St Mary s Hospital between 1985 and 1991 with 1273 seronegative controls on gender, sexual orientati
Judging a book by its cover: gay men's use of perceptible characteristics to infer antibody status.: Int J STD AIDS. 1996 Jan-Feb;7(1):39-43. Unique Identifier : AIDSLINE MED/96228424; Gold RS; Skinner MJ; School of Psychology, Deakin University, Victoria, Australia.; This study investigated gay men s use of perceptible characteristics to infer antibody status. Participants (n = 66) read brief descriptions of men they did not know and estimated the likelihood that they were HIV-infected. Each description highlighted one of 6 characteristics: physical attractiveness, intelligence/ed
Sexually transmissible agent and African Kaposi's sarcoma [editorial]: Int J STD AIDS. 1996 Jan-Feb;7(1):4-6. Unique Identifier : AIDSLINE MED/96228417; Matondo P; Sivapalan S; Kaposi s sarcoma (KS) has a higher incidence in some parts of Africa than anywhere else in the world. Recent studies in western homosexual men with AIDS-KS suggest that KS may be caused by a putative sexually transmissible agent. Our analytical review of studies on KS in Africa before and during the AIDS era reveals a
AIDS defining conditions in Africans resident in the United Kingdom.: Int J STD AIDS. 1996 Jan-Feb;7(1):44-7. Unique Identifier : AIDSLINE MED/96228425; Del Amo J; Goh BT; Forster GE; Ambrose King Centre, Department of Genitourinary Medicine, Royal; London Hospital, Whitechapel, UK.; A retrospective study of 55 HIV-1 seropositive African patients living in the UK, seen between January 1986 and November 1993, showed a total of 26 (47%) patients with AIDS. Thirty-one (56%) had symptomatic HIV disease at the time of presentation of whom 19 (34.5%) had an AIDS defining condition. Tuberculosis was the
Increasing trend of HIV seropositivity in a sexually transmitted diseases centre and epidemiology of HIV seropositive individuals.: Int J STD AIDS. 1996 Jan-Feb;7(1):48-50. Unique Identifier : AIDSLINE MED/96228426; Ray K; Ramesh V; Karmakar SN; Misra RS; Regional Sexually Transmitted Diseases Teaching, Training and; Research Centre, Safdarjang Hospital, New Delhi, India.; 11,539 STD clinic attenders and 20,897 antenatal clinic (ANC) attenders at a New Delhi hospital were screened for HIV antibodies by ELISA over a 3-year period. Results were confirmed by Western Blot. A low HIV seropositivity rate (1 per 1000) with an increasing trend in 1993 (4 per 1000) was observed in the STD attend
The effects of peer education on STD and AIDS knowledge among prisoners in Mozambique.: Int J STD AIDS. 1996 Jan-Feb;7(1):51-4. Unique Identifier : AIDSLINE MED/96228427; Vaz RG; Gloyd S; Trindade R; National Institute of Health, Ministry of Health, Maputo,; Mozambique,; The study was designed to evaluate the impact of education on AIDS knowledge among prison inmates in Maputo, Mozambique . A 6-month follow-up study was carried out in 1993 among 300 prisoners. A knowledge, attitudes, and practices questionnaire regarding AIDS and STD was adminis
Autoimplantation technique in the treatment of anogenital warts: a clinico-immunological study.: Int J STD AIDS. 1996 Jan-Feb;7(1):55-7. Unique Identifier : AIDSLINE MED/96228428; Usman N; Udayashankar K; Subramanian S; Thyagarajan SP; Department of Sexually Transmitted Diseases, Government Stanley; Hospital, Madras, India.; An autoimplantation technique was adopted in the treatment of 50 cases of anogenital warts and was compared with the conventionally used podophyllin regimen in a matched group of 50 patients. They were assessed with 15 untreated subjects in a control group for the rate of clinical cure after 6 weeks, recurrence after
Undernotification of tuberculosis in patients with AIDS.: Int J STD AIDS. 1996 Jan-Feb;7(1):58-60. Unique Identifier : AIDSLINE MED/96228429; Balogun MA; Wall PG; Noone A; Parkside Health Authority, London, UK.; The purpose of this study was to establish the extent of undernotification of tuberculosis in AIDS patients resident in 2 inner London local authorities. For residents of the 2 authorities, statutory notifications of tuberculosis between 1986 and 1992 were compared, using soundex codes of surnames, sex and year of bir
Coinfection with chlamydia and gonorrhoea among pregnant women and bacterial vaginosis.: Int J STD AIDS. 1996 Jan-Feb;7(1):61-4. Unique Identifier : AIDSLINE MED/96228430; Joesoef MR; Wiknjosastro G; Norojono W; Sumampouw H; Linnan M; Hansell MJ; Hillis SE; Lewis J; Division of STDHIV Prevention, Centers for Disease Control and; Prevention, Atlanta, Georgia, USA.; The role of sexual transmission of microorganisms in bacterial vaginosis (BV) is controversial. If sexual intercourse were a risk factor for BV, then we would expect that women with BV would also be coinfected with other sexually transmitted diseases (STD). We investigated the prevalence of STD among pregnant women a
Contraceptive use and HIV infection in Kenyan family planning clinic attenders.: Int J STD AIDS. 1996 Jan-Feb;7(1):65-70. Unique Identifier : AIDSLINE MED/96228431; Sinei SK; Fortney JA; Kigondu CS; Feldblum PJ; Kuyoh M; Allen MY; Glover LH; Department of Obstetrics and Gynaecology, University of Nairobi,; Kenya.; This pilot study aimed to determine the feasibility of a larger study of contraception and risk of HIV infection in women. We also measured risk factors for and occurrence of HIV infection in the participants. A cohort of 1537 seronegative women attending a family planning clinic in Nairobi,
Syphilis makes a comeback [editorial]: Int J STD AIDS. 1996 Jan-Feb;7(1):7-9. Unique Identifier : AIDSLINE MED/96228418; Drusin LM
Azithromycin in sexually transmitted diseases.: Int J STD AIDS. 1996;7 Suppl 1:1. Unique Identifier : AIDSLINE MED/96230310; Ridgway GL; University College London Hospitals, London, UK.
Treatment of syphilis with azithromycin.: Int J STD AIDS. 1996;7 Suppl 1:13-5. Unique Identifier : AIDSLINE MED/96230314; Mashkilleyson AL; Gomberg MA; Mashkilleyson N; Kutin SA; Semashko Moscow Medical School, Russia.; The efficacy of oral azithromycin (500 mg daily for 10 days or 500 mg on alternate days for 11 days) in 100 patients with seropositive syphilis was studied. Clinical manifestations regressed more rapidly in azithromycin-treated patients compared with patients who received erythromycin or penicillin, and there was also
Azithromycin in the management of opportunistic infections.: Int J STD AIDS. 1996;7 Suppl 1:17. Unique Identifier : AIDSLINE MED/96230315; Young LS; Kuzell Institute for Infectious Diseases and Arthritis, San; Francisco, USA.
The potential role of azithromycin in the treatment of prophylaxis of toxoplasmosis.: Int J STD AIDS. 1996;7 Suppl 1:18-22. Unique Identifier : AIDSLINE MED/96230316; Chang HR; Department of Microbiology, Faculty of Medicine, National; University of Singapore, Singapore.; Infection with Toxoplasma gondii is the most common parasitic infection worldwide with an estimated prevalence of 1-2 billion people. The risk of developing severe toxoplasmosis is higher for immunocompromised individuals and fetuses of mothers who have acquired a primo-infection. The current therapy of choice for tox
Azithromycin in gonorrhoea.: Int J STD AIDS. 1996;7 Suppl 1:2-4. Unique Identifier : AIDSLINE MED/96230311; Waugh MA; Leeds General Infirmary, UK.; The clinical applications of azithromycin in gonorrhoea, often complicated by simultaneously acquired infection with Chlamydia trachomatis, are reviewed in this paper. Clinical trails from major centres in Europe are compared with a large, more recent US study. At the present time, azithromycin is recommended througho
Treatment and prophylaxis of Mycobacterium avium complex.: Int J STD AIDS. 1996;7 Suppl 1:23-7. Unique Identifier : AIDSLINE MED/96230317; Young LS; Kuzell Institute for Arthritis & Infectious Diseases, California; Pacific Medical Center, San Francisco, USA.; The most common pathogens involved in disseminated bacterial infection in people with acquired immunodeficiency syndrome (AIDS) are organisms of the Mycobacterium avium-intracellulare complex (MAC). Azithromycin and clarithromycin, a new azalide and macrolide, respectively, are among the most potent monotherapies for
Human cryptosporidiosis.: Int J STD AIDS. 1996;7 Suppl 1:28-33. Unique Identifier : AIDSLINE MED/96230318; Hoepelman IM; Department of Medicine, Eijkman Winkler Laboratory for Medical; Microbiology, University Hospital, Utrecht, The Netherlands.; Cryptosporidium parvum is a protozoan which can cause severe debilitating disease in immunocompromised individuals. Animal models have shown that cellular immunity is the most important factor against the development of the disease. Individuals with a humoral immune deficiency are also at risk. In HIV-infected patient
Azithromycin in the prophylaxis of opportunistic infections in AIDS.: Int J STD AIDS. 1996;7 Suppl 1:34-7. Unique Identifier : AIDSLINE MED/96230319; McCutchan JA; UCSD Treatment Center, Department of Medicine, San Diego,; California, USA.; Prevention of opportunistic infections contributes to improved quality of life and survival in individuals with acquired immunodeficiency syndrome (AIDS). Agents which are more effective and convenient, less costly, and better tolerated are needed for multiple organism primary prophylaxis. Azithromycin, azalide with h
Azithromycin in the management of Chlamydia trachomatis infections.: Int J STD AIDS. 1996;7 Suppl 1:5-8. Unique Identifier : AIDSLINE MED/96230312; Ridgway GL; Department of Clinical Microbiology, University College London; Hospitals, UK.; The unique pharmacological profile of the azalide macrolide azithromycin, coupled with its in vitro activity against both Chlamydia trachomatis and the ureaplasmas, suggested that genital infections caused by these bacteria could be successfully treated with a single dose of the antibiotic. This has now been confirmed
Treatment of chancroid with azithromycin.: Int J STD AIDS. 1996;7 Suppl 1:9-12. Unique Identifier : AIDSLINE MED/96230313; Ballard RC; Ye H; Matta A; Dangor Y; Radebe F; National Reference Centre for Sexually Transmitted Diseases,; South African Institute for Medical Research, Johannesburg, South; Africa.; A randomized, comparative study undertaken in Nairobi, Kenya and a non-comparative evaluation undertaken in Carletonville, South Africa have both shown that a single oral dose of azithromycin 1 g is effective in the treatment of the genital ulce
[Comments on the position of Sibrowski et al. on the comment by v. Bormann et al.: autologous blood is safer than donated blood--fact or fiction? (letter)]: Anasthesiol Intensivmed Notfallmed Schmerzther. 1996 Mar;31(2):120. Unique Identifier : AIDSLINE MED/96204159; Lorentz A; Tolksdorf B; Becker P
Kaposi's sarcoma-associated herpesvirus (KSHV or HHV8) in primary effusion lymphoma: ultrastructural demonstration of herpesvirus in lymphoma cells.: Blood. 1996 Jun 15;87(12):4937-43. Unique Identifier : AIDSLINE MED/96247494; Said W; Chien K; Takeuchi S; Tasaka T; Asou H; Cho SK; de Vos S; Cesarman E; Knowles DM; Koeffler HP; Department of Pathology, Cedars Sinai Medical Center, Los; Angeles, CA 90048, USA.; Recent molecular evidence suggests an association with a new herpesvirus, Kaposi s sarcoma-associated herpesvirus (KSHV/HHV-8), and primary effusion lymphomas (PELs). PELs have a characteristic morphology, phenotype, and clinical presentation, with malignant effusions in the absence of a contiguous solid tumor mass. W
Fas-mediated apoptosis of CD4+ and CD8+ T cells from human immunodeficiency virus-infected persons: differential in vitro preventive effect of cytokines and protease antagonists.: Blood. 1996 Jun 15;87(12):4959-66. Unique Identifier : AIDSLINE MED/96247497; Estaquier J; Tanaka M; Suda T; Nagata S; Golstein P; Ameisen JC; Inserm U415, Lille, France.; Human immunodeficiency syndrome (HIV) infection leads to a progressive loss of T-cell-mediated immunity associated with T-cell apoptosis. We report here that CD4+ and CD8+ T cells from HIV-1-infected persons are sensitive to Fas (CD95/APO-1)-mediated death induced either by an agonistic anti-Fas antibody or by the phy
Single human T cells stimulated in the absence of feeder cells transcribe interleukin-2 and undergo long-term clonal growth in response to defined monoclonal antibodies and cytokine stimulation.: Blood. 1996 Jun 15;87(12):5179-84. Unique Identifier : AIDSLINE MED/96247520; Sunder-Plassmann R; Breiteneder H; Zimmermann K; Strunk D; Majdic O; Knapp W; Holter W; Institute of Immunology, University of Vienna, Austria.; The two-signal model of T-cell activation postulates that T lymphocytes require at least two distinct signals for activation. This model has been established with bulk cultures of T cells in which T-cell-T-cell interaction can occur, possibly delivering further unrecognized costimulatory signals. The signal requiremen
Antiphosphatidylserine antibodies in human immunodeficiency virus-1 patients with evidence of T-cell apoptosis and mediate antibody-dependent cellular cytotoxicity.: Blood. 1996 Jun 15;87(12):5185-95. Unique Identifier : AIDSLINE MED/96247521; Silvestris F; Frassanito MA; Cafforio P; Potenza D; Di Loreto M; Tucci M; Grizzuti MA; Nico B; Dammacco F; Department of Biomedical Sciences and Human Oncology, University; of Bari, Medical School, Bari, Italy.; Serum reactivities to a panel of phospholipid antigens, including cardiolipin (CL), phosphatidylserine (PS), sphingomyelin, phosphatidylcholine, and phosphatidylethanolamine, were measured by enzyme-linked immunosorbent assay in 196 human immunodeficiency virus-l+ (HIV-1+) patients with CDC II to IVC clinical disease.
[HIV infections in Germany (editorial)]: Bildgebung. 1995 Dec;62(4):242-3. Unique Identifier : AIDSLINE MED/96227393; Goebel FD
[Endoscopy of the upper gastrointestinal tract in HIV disease]: Bildgebung. 1995 Dec;62(4):244-51. Unique Identifier : AIDSLINE MED/96227394; Caca K; Zietz C; Bogner JR; Goebel FD; Zoller WG; Klinikum Innenstadt, Ludwig-Maximilians-Universitat Munchen,; Deutschland.; Gastrointestinal (GI) symptoms are part of the most frequent complaints in HIV disease. A methodical effort is required to identify treatable syndromes. Progressive immunodeficiency is associated with increased prevalence of opportunistic or non-opportunistic infections and neoplasms. Dysphagia and odynophagia, in the
[HIV infection and the lower gastrointestinal tract--characteristics of endoscopic diagnosis]: Bildgebung. 1995 Dec;62(4):252-8. Unique Identifier : AIDSLINE MED/96227395; Mauss S; Borchard F; Jablonowski H; Niederau C; Klinik fur Gastroenterologie, Hepatologie und Infektiologie,; Heinrich-Heine-Universitat, Dusseldorf, Deutschland.; In the course of HIV infection intestinal complaints, particularly diarrhoea, are frequent. As a result of the HIV-induced immunosuppression infections with unusual viral, mycobacterial and protozoan pathogens occur. In addition usually self-limiting intestinal infections become frequently persistent in HIV-positive p
[HIV infection: findings in liver and bile ducts]: Bildgebung. 1995 Dec;62(4):260-70. Unique Identifier : AIDSLINE MED/96227396; Jablonowski H; Klinik fur Gastroenterologie, Hepatologie und Infektiologie,; Heinrich-Heine-Universitat, Dusseldorf, Deutschland.; Gastrointestinal diseases in HIV-infected patients mainly affect the bowel, the oesophagus, and the liver. Most of the hepatic diseases are due to opportunistic infections and associated to AIDS. In the advanced AIDS disease Mycobacterium avium intracellulare is the most frequent bacterial infections agent. Mycobacter
[Ultrasound findings in HIV patients]: Bildgebung. 1995 Dec;62(4):271-80. Unique Identifier : AIDSLINE MED/96227397; Luthen R; Niederau C; Klinik fur Gastroenterologie, Hepatologie und Infektiologie,; Heinrich-Heine-Universitat, Dusseldorf, Deutschland.; A wide range of abnormal findings can be seen at abdominal ultrasonography in patients with HIV infection. The most frequent findings, hepatomegaly, splenomegaly, and enlarged lymph nodes, are nonspecific, however. Increased echogenicity or focal lesions of parenchymal organs, dilated bile ducts, nephromegaly, gut wal
[Ultrasound skin findings in HIV infection by imaging with 7.5 MHz linear transducers]: Bildgebung. 1995 Dec;62(4):281-6. Unique Identifier : AIDSLINE MED/96227398; Bogner JR; Rocken M; Medizinische Poliklinik, Universitat Munchen, Deutschland.; Sonography is an important tool in aiding the diagnosis of tumor-like and cystic findings in the skin and soft tissues. This is also true in patients with HIV infection and AIDS. While sonography of the skin often is performed with 20-MHz transducers, also lower-frequency devices which are more readily available contr
[AIDS: infections of the retina and choroid]: Bildgebung. 1995 Dec;62(4):288-301. Unique Identifier : AIDSLINE MED/96227399; Schimkat M; Althaus C; Augenklinik der Medizinischen, Einrichtungen der; Heinrich-Heine-Universitat Dusseldorf, Deutschland.; Various viral, bacterial, parasitic and fungal agents have been found to cause infections of retina and choroidea in HIV-infected patients. Usually these infections are opportunistic infections caused by the profound immunodeficiency, which is a result of the decay of lymphocytes by HIV. Before the HIV epidemic only r
[Differential radiologic diagnosis of HIV-associated lung diseases]: Bildgebung. 1995 Dec;62(4):302-9. Unique Identifier : AIDSLINE MED/96227400; Becker-Gaab C; Kuffer G; Kammer B; Bogner JR; Institut fur Radiologische Diagnostik,; Ludwig-Maximilians-Universitat, Munchen, Deutschland.; In 1993 in Germany an estimated number of 50,000-70,000 individuals were infected with the human immunodeficiency virus (HIV), WHO estimations ranged up to 14 million HIV-positive individuals including 1 million children. AIDS-related diseases frequently occur in the lung. 65% of
Imaging methods as a diagnostic tool in neuro-AIDS. A review.: Bildgebung. 1995 Dec;62(4):310-9. Unique Identifier : AIDSLINE MED/96227401; Arendt G; Neurologische Klinik, Universitat Dusseldorf, Germany.; Since 1983, central nervous system (CNS) involvement in acquired immune deficiency syndrome (AIDS) is well recognized. Imaging methods are important in diagnosing AIDS-related primary and secondary CNS processes as HIV-1-associated encephalopathy, cerebral toxoplasmosis, primary CNS ly
Intensification of donor interviewing procedures: a feasibility study.: Infusionsther Transfusionsmed. 1996 Feb;23(1):32-4. Unique Identifier : AIDSLINE MED/96220386; van Rhenen DJ; Molijn MH; Gorgels J; van der Linden JM; Ko LK; Red Cross Blood Bank Rotterdam, The Netherlands.; OBJECTIVE: To determine the feasibility and acceptability for the blood donor of an intensified blood donor interviewing procedure on high-risk factors for infectious diseases. To answer the question whether an intensified blood donor interviewing procedure would lead to an unacceptable loss of blood donors. DESIGN: F
[Importance of introduction of PCR in blood banks (editorial)]: Infusionsther Transfusionsmed. 1996 Feb;23(1):4-6. Unique Identifier : AIDSLINE MED/96220381; Gurtler L
Impending flu pandemic [news]: Can Fam Physician. 1996 Apr;42:805-7. Unique Identifier : AIDSLINE MED/96225151; Kermode-Scott B
Chronic care. The military's assault on AIDS.: Hosp Health Netw. 1996 Jul 5;70(13):38. Unique Identifier : AIDSLINE MED/96283616; MacPherson P
AIDS and HIV-1 infection worldwide.: Commun Dis Rep CDR Wkly. 1996 May 17;6(20):179-80. Unique Identifier : AIDSLINE MED/96250775
Using administratively collected hospital discharge data for AIDS surveillance.: Ann Epidemiol. 1995 Sep;5(5):337-46. Unique Identifier : AIDSLINE MED/96113142; Payne SM; Seage GR 3rd; Oddleifson S; Gallagher K; vanBeuzekom M; Losina H; Hertz T; Health Services Department, Boston University School of Public; Health, MA 02118, USA.; The objectives of this study were twofold: to improve methods of identifying possible and acquired immunodeficiency syndrome (AIDS)-related hospital discharges in administrative databases and to measure AIDS-reporting completeness in Massachusetts both overall and by subgroup. We used fiscal year 1988 discharge data f
The value of the lymphocyte proliferation test with phytohemagglutinin in the immune evaluation of Brazilian HIV-infected patients.: J Investig Allergol Clin Immunol. 1995 Nov-Dec;5(6):347-9. Unique Identifier : AIDSLINE MED/96246788; Casseb JS; Benard G; Saito R; Brigido LF; Tanaami D; Joaquim ES; Duarte AJ; Immunogenetic and Experimental Transplantation Laboratory,; University of Sao Paulo, Brazil.; We evaluated phytohemagglutinin (PHA) lymphocyte proliferation and delayed-type hypersensitivity tests in 130 Brazilian HIV-infected patients with the objective of assessing the value of these tests in staging HIV infection. Patients were divided into three groups according to their CD4+ cell counts (cells/mm3):
Importance of human immunodeficiency virus-associated lymphadenopathy and tuberculous lymphadenitis in patients undergoing lymph node biopsy in Zambia.: Br J Surg. 1996 Jan;83(1):75-8. Unique Identifier : AIDSLINE MED/96264054; Bem C; Patil PS; Bharucha H; Namaambo K; Luo N; School of Medicine, University of Zambia, Republic of Zambia.; The relative importance of human immunodeficiency virus (HIV)-associated lymphadenopathy amongst patients presenting for lymph node biopsy in Central Africa is unknown. HIV-1 serology and histology of patients undergoing superficial lymph node biopsy during 1989-1990 in Lusaka, Zambia
Changes in dentists' infection control practices, knowledge, and attitudes about HIV over a 2-year period.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996 Mar;81(3):297-302. Unique Identifier : AIDSLINE MED/96252799; McCarthy GM; Koval JJ; Faculty of Dentistry, University of Western Ontario, London,; Canada.; OBJECTIVE. To investigate changes in the infection control practices, attitudes, and knowledge of dentists as they relate to HIV/AIDS. STUDY DESIGN. A comparison of responses to surveys conducted in 1992 (n = 258) and 1994 (n = 262) with the use of univariate/multivariate analyses and McNemar s test for paired data. R
New nucleoside analogue, lamivudine, released for HIV therapy [news]: Am J Health Syst Pharm. 1996 Jan 15;53(2):116. Unique Identifier : AIDSLINE MED/96263409
Doxorubicin liposome formulation gains marketing approval [news]: Am J Health Syst Pharm. 1996 Jan 15;53(2):116, 119. Unique Identifier : AIDSLINE MED/96263410
Antisense strategies and therapeutic applications.: Am J Health Syst Pharm. 1996 Jan 15;53(2):151-60; quiz 182-3. Unique Identifier : AIDSLINE MED/96263414; Putnam DA; Department of Pharmaceutics and Pharmaceutical Chemistry,; University of Utah, Salt Lake City, UT 84112, USA.; The concepts underlying the antisense approach to disease therapy are discussed, and potential applications are examined. Antisense therapeutic agents bind to DNA or RNA sequences, blocking the synthesis of cellular proteins with unparalleled specificity. Transcription and translation are the two processes with which
[Nervous system infections by retroviruses]: Rev Neurol. 1996 Jun;24(130):703-7. Unique Identifier : AIDSLINE MED/96244171; Roman GC; Institutos Nacionales de Salud de los EE. UU, Universidad de; Tejas en San Antonio, USA.
[The Bratislava International Eye Bank--a member of the International Federation of Eye Banks]: Cesk Slov Oftalmol. 1996 Feb;52(1):34-8. Unique Identifier : AIDSLINE MED/96213459; Cernak A; Galikova M; Ocna klinika IVZ, Bratislava.; The International Eye Bank in Bratislava has assembled during its two-year activities 1007 corneae with a 2mm scleral margin by excision performed in the donor in situ, 11 total eye-balls and 43 sclerae. From this total number 1331 eye tissues had to be eliminated because of serum positivity (115 HBsAg, 12 HCV, 2 HIV
Collaborative care receives stamp of approval in CMA, CNA study involving HIV/AIDS.: Can Med Assoc J. 1996 Jun 15;154(12):1898-9. Unique Identifier : AIDSLINE MED/96258836; Walters D; Morgan D; Colbran-Smith M; The CMA wants to work with national health care groups, such as the Canadian Nurses Association (CNA), to explore ways providers can work collaboratively to provide quality health care. A joint working group of the CMA and the CNA recently examined collaborative care, focusing on examples provided in HIV/AIDS care. Th
Lower lung field tuberculosis in Yaounde, Cameroon.: Cent Afr J Med. 1996 Mar;42(3):62-5. Unique Identifier : AIDSLINE MED/96250764; Kuaban C; Fotsin JG; Koulla-Shiro S; Ekono MR; Hagbe P; Department of Internal Medicine, Faculty of Medicine and; Biomedical Sciences, University of Younde 1/Jamot Hospital; Younde, Cameroon.; Lower lung field tuberculosis was investigated in 273 consecutive adult patients with pulmonary tuberculosis admitted into the Chest Unit of the Jamot Hospital in Yaounde from December 1991 to July 1992. Twenty eight cases were found representing 10.3 pc of the total admissions with pulmonary tuberculosis. Twenty thre
HTLV-I infection in the Free State region of South Africa: a sero-epidemiologic study.: Cent Afr J Med. 1996 Mar;42(3):65-8. Unique Identifier : AIDSLINE MED/96250765; van der Ryst E; Joubert G; Smith MS; Terblanche M; Mollentze F; Pretorius AM; Department of Virology, University of the Orange Free State,; Bloemfotein, South Africa.; Human T-lymphotropic virus type I (HTLV-1) is associated with tropical spastic paraparesis (TSP) and adult T-cell leukemia/lymphoma. HTLV-I infection is endemic in certain parts of the Natal/KwaZulu region of South Africa . No studies on the seroprevalence of HTLV-I infection in th
Reproductive and sexual health: a research and developmental challenge.: Cent Afr J Med. 1996 Mar;42(3):80-5. Unique Identifier : AIDSLINE MED/96250771; Mbizvo MT; Department of Obstetrics and Gynaecology, University of Zimbabwe,; Harare, Zimbabwe.; There is a growing awareness of the burden and implications of reproductive ill health as contributed by unsafe motherhood (during pregnancy, childbirth, abortion), reproductive tract infection (RTIs) and cancer, sexually transmitted infections (STIs) including the human immunodeficiency virus (HIV), poorly regulated
Leishmaniasis in AIDS patients: results of leukocytoconcentration, a fast biological method of diagnosis.: Bull World Health Organ. 1996;74(1):91-3. Unique Identifier : AIDSLINE MED/96267283; Izri MA; Deniau M; Briere C; Rivollet D; Petithory JC; Houin R; Rousset JJ; Laboratory of Parasitology, Hopital Avicenne, Bobigny, France.; Leukocytoconcentration is an easy, fast and inexpensive technique for the diagnosis of leishmaniasis from peripheral blood. The technique involves concentration of blood parasites on a small surface of a microscope slide while the red blood cells are removed by lysis. The results, compared with those of other methods
Fluorometric detection of HIV-1 genome through use of an internal control, inosine-substituted primers, and microtiter plate format.: Clin Chem. 1996 May;42(5):696-703. Unique Identifier : AIDSLINE MED/96211420; Gerard B; Peponnet C; Brunie G; Cave H; Denamur E; d'Auriol L; Monplaisir N; Simon F; Elion J; Grandchamp B; Service de Biochimie Genetique, Hopital Robert Debre, Paris,; France.; We describe a PCR-based fluorometric assay for the detection of the HIV-1 genome. This technique consists of a reverse hybridization with oligonucleotide probes covalently coated onto a microtiter plate as a solid support. Several improvements to the PCR amplification and detection steps gave greater sensitivity and s
Human immunodeficiency virus and the orthopaedic surgeon.: Clin Orthop. 1996 Jul;(328):31-3. Unique Identifier : AIDSLINE MED/96266877; Hamilton JB; Department of Orthopaedic Surgery and Haematology, Bradford; Hospitals, Bradford, United Kingdom.; Human immunodeficiency virus is a devastating disease that ends in death. The fear that it engenders in healthworkers and patients may be out of proportion to the risks involved but an emotional response to the dangers is understandable. However, a careful study of the risks, the adoption of high standards of practice
Long term evaluation of septic arthritis in hemophilic patients.: Clin Orthop. 1996 Jul;(328):54-9. Unique Identifier : AIDSLINE MED/96266881; Gilbert MS; Aledort LM; Seremetis S; Needleman B; Oloumi G; Forster A; Department of Orthopedics, Mount Sinai Hospital, New York, NY,; USA.; Before 1983, septic arthritis was rare in patients with hemophilia. With the advent of human immunodeficiency virus infection in the hemophilia population, many centers noted an increasing incidence of patients with septic arthritis. Fifteen septic joints in 10 patients with severe hemophilia were documented. Eight pa
Intraocular silicone oil for retinal detachment in AIDS: CT and MR appearances.: Clin Radiol. 1996 Jun;51(6):415-7. Unique Identifier : AIDSLINE MED/96262157; Murray JG; Gean AD; Barr RM; Department of Radiology, San Francisco General Hospital, USA.; AIM: To describe the CT and MR features of intraocular silicone oil which is used to treat complex retinal detachments in patients with acquired immune deficiency syndrome (AIDS). PATIENTS AND METHODS: Seven male patients with AIDS were treated by pars plana vitrectomy and intraocular silicone oil injection for comple
Unusual cause of fever and diarrhea in a patient with AIDS. Penicillium marneffei infection.: Dig Dis Sci. 1996 Jun;41(6):1212-5. Unique Identifier : AIDSLINE MED/96258878; Leung R; Sung JY; Chow J; Lai CK; Department of Medicine, Prince of Wales Hospital, Shatin, Hong; Kong.; Penicillium marneffei is an opportunistic pathogen predominantly found in Southeast Asia. Systemic infection of Penicillium marneffei has protean manifestations including fever, weight loss, anaemia, skin lesions, and lymphadenopathy. We report a rare case of penicillium colitis in an AIDS patient who responded succes
Effect of human immunodeficiency virus infection on hepatitis C virus infection in hemophiliacs.: Dig Dis Sci. 1996 Jun;41(6):1265-72. Unique Identifier : AIDSLINE MED/96258886; Ghany MG; Leissinger C; Lagier R; Sanchez-Pescador R; Lok AS; Department of Medicine, Tulane University School of Medicine, New; Orleans, Louisiana, USA.; Chronic liver disease due to hepatitis C virus (HCV) infection is a major problem in hemophiliacs. Recent reports suggested that hemophiliacs coinfected with hepatitis C virus and human immunodeficiency virus (HIV) have an increased incidence of liver failure but the mechanism of accelerated liver injury is not clear.
[Prevalence of Cryptosporidium sp and Isospora belli in patients with acquired immunodeficiency syndrome (AIDS) in Dakar (Senegal]: Dakar Med. 1994;39(2):121-4. Unique Identifier : AIDSLINE MED/96220614; Dieng T; Ndir O; Diallo S; Coll-Seck AM; Dieng Y; Service de Parasitologie-Mycologie, Faculte de Medecine et de; Pharmacie, Dakar.; 72 patients with AIDS, having diarrhoea and admitted in the Unit of Infectious diseases, Fann Hospital from 1989 to 1991 were investigated for Cryptosporidium sp. and Isospora belli isolation by the modified Ziehl-Neelsen technique, after stolls concentration by Ritchie technique. The prevalence were 13.9% for Crypto
Nerve conduction changes in asymptomatic HIV-1 seropositive individuals in the absence of other risk factors for neuropathy.: Electromyogr Clin Neurophysiol. 1996 Jan-Feb;36(1):3-8. Unique Identifier : AIDSLINE MED/96244706; Malessa R; Agelink M; Himmelmann M; Kloss T; Mertins L; Brockmeyer NH; Department of Neurology, University of Essen, Germany.; The major problem in determining the role of HIV-1 infection in the pathogenesis of peripheral neuropathy is the difficulty in separating possible effects of confounding factors such as other infections, malnutrition, neurotoxic medication, drug abuse and antiretrovir
Concordance between polymerase chain reaction and antibody detection in the diagnosis of human immunodeficiency virus type 1 infection.: Eur J Clin Microbiol Infect Dis. 1995 Nov;14(11):1011-14. Unique Identifier : AIDSLINE MED/96246490; Romano L; Catucci M; De Milito A; Venturi G; Zazzi M; Almi P; Gonnelli A; Rubino M; Maestrini R; Valensin PE; Dipartimento di Biologia Molecolare, Universita di Siena, Italy.; A highly sensitive nested polymerase chain reaction (PCR) protocol was used to detect human immunodeficiency virus type 1 (HIV-1) DNA in peripheral blood mononuclear cells from 271 HIV-1-seropositive patients, 240 HIV-1-seronegative subjects at increased risk for HIV-1 infection, 51 serologically indeterminate individ
Influence of human immunodeficiency virus type 1 infection on the natural course of chronic parenterally acquired hepatitis C.: Eur J Clin Microbiol Infect Dis. 1995 Nov;14(11):949-53. Unique Identifier : AIDSLINE MED/96246479; Sanchez-Quijano A; Andreu J; Gavilan F; Luque F; Abad MA; Soto B; Munoz J; Aznar JM; Leal M; Lissen E; Department of Internal Medicine, Virgen del Rocio University; Hospital, Seville, Spain.; The aim of the present study was to investigate the possible role of human immunodeficiency virus (HIV) infection in the natural course of chronic hepatitis C. Seventy-six adult patients with chronic parenterally acquired hepatitis C virus (HCV) infection examined from 1989 to 1993 were enrolled; of these 32 (42.1%) w
Development of subtle neurological signs after systemic illness in HIV-infected individuals.: Eur Neurol. 1996;36(2):71-5. Unique Identifier : AIDSLINE MED/96233869; Lopez OL; Becker JT; Banks G; Giconi J; Sanchez J; Dorst SK; Department of Neurology, University of Pittsburgh School of; Medicine, Pa, USA.; Thirty human immunodeficiency virus (HIV) infected individuals entered a longitudinal study without signs of dysfunction of the central nervous system (CNS). Nine of these individuals developed a systemic illness between study visits, and 7 of these 9 patients (78%) had neurological signs at the next examination (e.g.
Emergence of cryptococcal disease: epidemiologic perspectives 100 years after its discovery.: Epidemiol Rev. 1995;17(2):303-20. Unique Identifier : AIDSLINE MED/96261321; Hajjeh RA; Brandt ME; Pinner RW; Emerging Bacterial and Mycotic Diseases Branch, Centers for; Disease Control and Prevention, Atlanta, GA 30333, USA.
Variation of intracellular distribution of mRNAs expressed from transfected cDNAs--a study by FISH.: Biochem Soc Trans. 1995 Nov;23(4):588S. Unique Identifier : AIDSLINE MED/96227277; Fu L; Suen CK; White KN; Division of Biochemistry and Molecular Biology, UMDS, Guy's; Hospital, London, U.K.
Nucleoside spiroxiranes as suicide inhibitors of the human immunodeficiency virus.: Biochem Soc Trans. 1995 Nov;23(4):619S. Unique Identifier : AIDSLINE MED/96227308; Bailey JM; Nelson KA; Department of Biochemistry and Molecular Biology, George; Washington University, School of Medicine and Health Sciences,; Washington, D.C., USA.
Refined solution structure of p17, the HIV matrix protein.: Biochem Soc Trans. 1995 Nov;23(4):725-9. Unique Identifier : AIDSLINE MED/96227117; Matthews S; Barlow P; Clark N; Kingsman S; Kingsman A; Campbell I; Department of Biochemistry, University of Oxford, U.K.
Reaching young adults through entertainment.: Popul Rep J. 1995 Oct;(41 Suppl |reaching|):4p.. Unique Identifier : AIDSLINE MED/96244100
pHIVTATA-CAT, a versatile vector to study transcriptional regulatory elements in mammalian cells.: Gene. 1996 Feb 12;168(2):173-6. Unique Identifier : AIDSLINE MED/96194892; Thiel G; Petersohn D; Schoch S; Institute for Genetics, University of Cologne, Germany.; thiel@genetik.uni-koeln.de; We have constructed a vector, pHIVTATA-CAT, that contains the Escherichia coli cat gene, encoding chloramphenicol acetyltransferase, under the control of a minimal promoter consisting of the HIV TATA box and the adenovirus major late promoter initiator element. Putative transcriptional elements can be inserted either
An evaluation of the antioxidant and antiviral action of extracts of rosemary and Provencal herbs.: Food Chem Toxicol. 1996 May;34(5):449-56. Unique Identifier : AIDSLINE MED/96243794; Aruoma OI; Spencer JP; Rossi R; Aeschbach R; Khan A; Mahmood N; Munoz A; Murcia A; Butler J; Halliwell B; Pharmacology Group, University of London King's College, UK.; Extracts of herbs and spices are increasingly of interest in the food industry because they retard oxidative degradation of lipids. There is also increasing interest in the antiviral activity of plant products. A liquid, deodorized rosemary extract and an oily extract of a mixture of Provencal herbs were tested for an
AIDS survival and progression in black Africans living in south London, 1986-1994.: Genitourin Med. 1996 Feb;72(1):12-6. Unique Identifier : AIDSLINE MED/96246549; Low N; Paine K; Clark R; Mahalingam M; Pozniak AL; Department of Genitourinary Medicine, King's College School of; Medicine & Dentistry, London.; OBJECTIVES: To describe the rate of progression to AIDS and survival following AIDS diagnosis in HIV-infected Africans living in London. To identify factors influencing progression and outcome of disease. DESIGN: Retrospectively constructed prevalent cohort. SETTING: Outpatient clinic population, London. SUBJECTS: HIV
Ups and downs--and ups in the antiviral therapy of HIV infection.: Genitourin Med. 1996 Feb;72(1):2-5. Unique Identifier : AIDSLINE MED/96246546; Weller IV; Williams I; Department of Sexually Transmitted Diseases, University College; London Medical School.
Reference ranges and sources of variability of CD4 counts in HIV-seronegative women and men.: Genitourin Med. 1996 Feb;72(1):27-31. Unique Identifier : AIDSLINE MED/96246552; Maini MK; Gilson RJ; Chavda N; Gill S; Fakoya A; Ross EJ; Phillips AN; Weller IV; Department of Genitourinary Medicine, Camden and Islington; Community Health Services NHS Trust, London, UK.; BACKGROUND: CD4 lymphocyte counts are used to monitor immune status in HIV disease. An understanding of the variability of CD4 counts which occurs in the absence of HIV infection is essential to their interpretation. The sources and degree of such variability have not been extensively studied. OBJECTIVES: To establish
Changes in sexual behaviour of patients attending an HIV testing centre: a prospective study 1988-1994.: Genitourin Med. 1996 Feb;72(1):37-42. Unique Identifier : AIDSLINE MED/96246554; Cribier B; Schmitt MP; Le Coz C; Grosshans E; Clinique Dermatologique, Hopitaux Universitaires, Strasbourg,; France.; OBJECTIVE: To evaluate the sexual behaviour changes in patients attending HIV testing during the period July 1988 to June 1994. DESIGN: In a prospective study, 6824 face-to-face interviews were carried out before the HIV test was performed. The frequency of condom use and the number of sexual partners during the 6 pre
Sexual health and use of condoms among local and international sex workers in Sydney.: Genitourin Med. 1996 Feb;72(1):47-51. Unique Identifier : AIDSLINE MED/96246556; O'Connor CC; Berry G; Rohrsheim R; Donovan B; Academic Unit of Sexual Health Medicine, University of Sydney,; Australia.; OBJECTIVES: To compare indicators of sexual health and predictors of condom use for commercial sex among local and international female sex workers first attending an STD clinic. SETTING: A public STD clinic in Sydney, Australia . SUBJECTS: All sex workers first attending between
Fatal haemorrhage following liver biopsy in patients with HIV infection.: Genitourin Med. 1996 Feb;72(1):62-4. Unique Identifier : AIDSLINE MED/96246560; Churchill DR; Mann D; Coker RJ; Miller RF; Glazer G; Goldin RD; Lucas SB; Weber JN; De Cock KM; Department of Genitourinary Medicine, Communicable Diseases, St; Mary's Hospital and Medical School, London.; A retrospective review of all 248 liver biopsies performed in patients with HIV infection at two referral centres in London over a 12 year period revealed five cases of major bleeding following biopsy, with four deaths. The risk of major bleeding was 2.0%, and mortality was 1.6% following liver biopsy. The risk of ble
Male duct ectasia associated with HIV infection.: Genitourin Med. 1996 Feb;72(1):65-6. Unique Identifier : AIDSLINE MED/96246561; Downs AM; Fisher M; Tomlinson D; Tanner A; Department GenitoUrinary Medicine, St Marys Hospital, London, UK.; The incidence of male duct ectasia (periductal mastitis) is extremely rare, only eight cases having been reported. The underlying cause (as in females) is uncertain. Two cases in HIV positive males of recurrent unilateral nipple lesions are reported with histology consistent with duct ectasia. At presentation neither
Gonorrhoea in HIV seropositive homosexual men attending an East London genitourinary medicine clinic [letter]: Genitourin Med. 1996 Feb;72(1):74. Unique Identifier : AIDSLINE MED/96246568; Lewis DA; Forster GE; Goh B
Community-based respiratory viral infections in HIV positive patients with lower respiratory tract disease: a prospective bronchoscopic study.: Genitourin Med. 1996 Feb;72(1):9-11. Unique Identifier : AIDSLINE MED/96246548; Miller RF; Loveday C; Holton J; Sharvell Y; Patel G; Brink NS; Academic Department of Genitourinary Medicine, University College; London Medical School.; OBJECTIVES: To evaluate the contribution of community-based respiratory virus infections to lower respiratory tract disease in HIV-1 infected individuals. DESIGN: Prospective clinical cohort study. SETTING: Specialist in-patient unit for HIV and AIDS, University College London Hospitals, London. SUBJECTS: 44 consecuti
Pharmacokinetics of orally administered zidovudine in HIV-infected children and adults.: Infection. 1995 Nov-Dec;23(6):344-8. Unique Identifier : AIDSLINE MED/96263607; Wintergerst U; Rolinski B; Vocks-Hauck M; Wahn V; Debatin KM; Notheis G; Grosch-Worner I; Goebel FD; Roscher AA; Belohradsky BH; Universitats-Kinderklinik Munchen, Germany.; The pharmacokinetics of oral zidovudine in HIV-infected children and adults are reported. Fourty-six patients were investigated. For data analysis three groups of similar size were formed: young children 4 months-4 years, n = 15 (group 1), older children up to 13 years, n = 16 (group 2) and young adults, n = 15 (group
Clinical and microscopical features of small-intestinal microsporidiosis in patients with AIDS.: Infection. 1995 Nov-Dec;23(6):362-8. Unique Identifier : AIDSLINE MED/96263610; Caramello P; Mazzucco G; Romeo M; Ullio A; DeRosa G; Lucchini A; Forno B; Brancale T; Macor A; Preziosi C; et al; Institute of Infectious Diseases, University of Turin, Italy.; Intestinal microsporidiosis by Enterocytozoon bieneusi is an increasingly recognized infection in AIDS patients. We report eight cases of microsporidiosis. All patients were severely immunodepressed. Clinical features were highly variable. Patients were followed up for
First case of HIV-1 subtype 0 infection in Germany.: Infection. 1995 Nov-Dec;23(6):369-70. Unique Identifier : AIDSLINE MED/96263611; Hampl H; Sawitzky D; Stoffler-Meilicke M; Groh A; Schmitt M; Eberle J; Gurtler L; Institut fur Klinische und Experimentelle Virologie, Freie; Universitat Berlin, Germany.
[HIV infections in Switzerland]: Internist (Berl). 1996 Apr;37(4):419-21. Unique Identifier : AIDSLINE MED/96230700; Schneider RE; Institut Froideville, Posieux.
Exogenous and endogenous opioids as biological response modifiers.: Immunopharmacology. 1995 Nov;31(1):59-71. Unique Identifier : AIDSLINE MED/96245822; Carr DJJ; Serou M; Department of Microbiology, Stanley S. Scott Cancer Center, New; Orleans, LA 70112-1393, USA. dcarr@pop3.1sumc.edu; Narcotic opioid compounds are among the most widely prescribed drug interventions for individuals suffering pain. Among the unwarranted side effects of respiratory depression, constipation, and physical dependence are the immunosuppressive qualities, particularly those which affect cell-mediated immunity. The immunosu
Stimulation of human immunodeficiency virus type 1 infected cells with superoxide enhances the chemotactic motile response of CD4+ human T cells: implication for virus transmission by cell-to-cell interaction.: Immunopharmacology. 1995 Nov;31(1):73-84. Unique Identifier : AIDSLINE MED/96245823; Okada Y; Kameoka M; Kimura T; Azuma I; Ikuta K; Institute of Immunological Science, Hokkaido University, Sapporo,; Japan.; We previously showed that superoxide (O2-) significantly enhanced human immunodeficiency virus type 1 (HIV-1)-induced syncytia formation in co-cultured infected and uninfected human T cells. In this study, we describe a novel chemotactic response of uninfected CD4+ T cells by stimulating infected T cells with O2-. Syn
Pentoxifylline therapy in HIV seropositive subjects with elevated TNF.: Immunopharmacology. 1995 Nov;31(1):85-91. Unique Identifier : AIDSLINE MED/96245824; Kruse A; Rieneck K; Kappel M; Orholm M; Bruunsgaard H; Ullum H; Skinhoj P; Pedersen BK; Department of Infectious Diseases, Copenhagen N, Denmark.; Tumor necrosis factor-alpha (TNF-alpha) is thought to induce cachexia in subjects infected with human immunodeficiency virus (HIV), and it has been suggested that HIV-seropositive patients would benefit from treatment with pentoxifylline, a known suppressor of TNF-alpha production. The purpose of the present study was
Expression of TIA-1 and TIA-2 in T cell malignancies and T cell lymphocytosis.: J Clin Pathol. 1996 Feb;49(2):154-8. Unique Identifier : AIDSLINE MED/96264437; Matutes E; Coelho E; Aguado MJ; Morilla R; Crawford A; Owusu-Ankomah K; Catovsky D; Academic Department of Haematology and Cytogenetics, Royal; Marsden Hospital, London.; OBJECTIVE: To investigate the reactivity with TIA-1 and TIA-2, two monoclonal antibodies that recognise, respectively, granular structures in T lymphocytes and the T cell receptor chain in cells from a variety of T cell disorders. METHODS: Cytoplasmic staining with TIA-1 and TIA-2 was carried out by the immunoalkaline
Herpes virus-like sequences are specifically found in Kaposi sarcoma lesions.: J Clin Pathol. 1996 Apr;49(4):306-8. Unique Identifier : AIDSLINE MED/96263265; O'Neill E; Henson TH; Ghorbani AJ; Land MA; Webber BL; Garcia JV; Department of Virology/Molecular Biology, St Jude Children's; Research Hospital, Memphis, TN 38105, USA.; AIM: To detect the prevalence of herpes virus-like DNA sequences in AIDS associated Kaposi sarcoma (KSHV) lesions and normal tissue. METHODS: KSHV detection was performed by polymerase chain reaction (PCR) using four different sets of primers. PCR products were cloned, sequenced, and analysed. RESULTS: All of four bio
Bacillus piliformis infection (Tyzzer's disease) in a patient infected with HIV-1: confirmation with 16S ribosomal RNA sequence analysis.: J Am Acad Dermatol. 1996 Feb;34(2 Pt 2):343-8. Unique Identifier : AIDSLINE MED/96225821; Smith KJ; Skelton HG; Hilyard EJ; Hadfield T; Moeller RS; Tuur S; Decker C; Wagner KF; Angritt P; AIDS Registry, Armed Forces Institute of Pathology, Washington,; D.C., USA.; Bacillus piliformis is a long, rod-shaped bacterium that has never been grown in cell-free medium and whose taxonomic classification is uncertain. B. piliformis is the causative agent of Tyzzer s disease, which is frequently reported in laboratory, wild, and domesticated animals. The spectrum and severity of this dise
CD7-positive Sezary syndrome with a Th1 cytokine profile.: J Am Acad Dermatol. 1996 Feb;34(2 Pt 2):368-74. Unique Identifier : AIDSLINE MED/96225827; Yagi H; Tokura Y; Furukawa F; Takigawa M; Department of Dermatology, Hamamatsu University School of; Medicine, Japan.; Sezary syndrome is a leukemic variant of cutaneous T-cell lymphoma characterized by the appearance of numerous CD4+ cells with cerebriform nuclei in the peripheral blood. Recent observations have suggested that Sezary cells lack CD7 molecules on their surface and are analogous to murine Th2 cells. It remains unclear,
Vaccines: new approaches and concepts.: J Allergy Clin Immunol. 1996 Apr;97(4):896-906. Unique Identifier : AIDSLINE MED/96194240; Dickler HB; Collier E; Clinical Immunology Branch, National Institute of Allergy and; Infectious Diseases, Bethesda, MD 20892, USA.
CD4 T-lymphocyte activation is associated with peak expiratory flow variability in childhood asthma.: J Allergy Clin Immunol. 1996 Apr;97(4):955-62. Unique Identifier : AIDSLINE MED/96194246; Doi S; Murayama N; Inoue T; Takamatsu I; Kameda M; Omoto Y; Toyoshima K; Department of Pediatric Allergy, Osaka Prefectural Habikino; Hospital, Japan.; BACKGROUND: Asthma has been recognized as a chronic inflammatory disorder of the airway. We have investigated the relationships among the activation markers on lymphocytes, eosinophils, their serum products in the peripheral blood, and the variability of airway obstruction in childhood asthma. METHODS: Twenty-two pati
Weight gain and increased concentrations of receptor proteins for tumor necrosis factor after patients with symptomatic HIV infection received fortified nutrition support.: J Am Diet Assoc. 1996 Jun;96(6):565-9. Unique Identifier : AIDSLINE MED/96248129; Suttmann U; Ockenga J; Schneider H; Selberg O; Schlesinger A; Gallati H; Wolfram G; Deicher H; Muller MJ; Zentrum Innere Medizin und Dermatologie, Abteilung Klinische; Immunologie, Lehrte, Germany.; OBJECTIVE: To determine whether certain nutrients and dietary factors act as modulators of the immune system and improve the nutritional status of immunocompromised patients. DESIGN: Controlled, double-blind, crossover phase trials of the effects of a fortified formula in patients infected with the human immunodeficie
AIDS in the elderly: New York City vital statistics.: J Emerg Med. 1996 Jan-Feb;14(1):19-23. Unique Identifier : AIDSLINE MED/96244975; Gaeta TJ; LaPolla C; Melendez E; Department of Emergency Medicine, St. Barnabas Hospital, Bronx,; New York 10457, USA.; The HIV infection primarily affects young adults, but older adults are also susceptible. The number of AIDS cases among persons aged 50 or greater is growing and is of major concern. As our awareness of the prevalence of HIV-related illnesses presenting to the emergency department improves in the younger population, w
Genetic diversity at the internal transcribed spacer regions of the rRNA operon among isolates of Pneumocystis carinii from AIDS patients with recurrent pneumonia.: J Infect Dis. 1996 Jul;174(1):141-56. Unique Identifier : AIDSLINE GENBANK/M96382; Tsolaki AG; Miller RF; Underwood AP; Banerji S; Wakefield AE; Department of Paediatrics, John Radcliffe Hospital, Oxford,; United Kingdom.; The opportunistic fungal pathogen Pneumocystis carinii sp. f. hominis is a frequent cause of pneumonia in the immunocompromised host. Analysis of genetic variation among isolates of P. carinii sp. f. hominis from 12 human immunodeficiency virus (HIV)-infected persons with single and multiple episodes of P. carinii pne
Lamivudine in children with human immunodeficiency virus infection: a phase I/II study. The National Cancer Institute Pediatric Branch-Human Immunodeficiency Virus Working Group.: J Infect Dis. 1996 Jul;174(1):16-25. Unique Identifier : AIDSLINE MED/96261989; Lewis LL; Venzon D; Church J; Farley M; Wheeler S; Keller A; Rubin M; Yuen G; Mueller B; Sloas M; Wood L; Balis F; Shearer GM; Brouwers P; Goldsmith J; Pizzo PA; Pediatric Branch, National Cancer Institute, National Institutes; of Health, Bethesda, Maryland, USA.; The safety, tolerability, pharmacokinetic profile, and preliminary activity of lamivudine (2 -deoxy-3 -thiacytidine), a novel cytidine nucleoside analogue with antiretroviral activity, in human immunodeficiency virus (HIV)-infected children beyond the neonatal period were studied. Ninety children received dosages of 1
Cytomegalovirus glycoprotein B groups associated with retinitis in AIDS.: J Infect Dis. 1996 Jul;174(1):184-7. Unique Identifier : AIDSLINE MED/96262011; Shepp DH; Match ME; Ashraf AB; Lipson SM; Millan C; Pergolizzi R; Department of Medicine, North Shore University Hospital,; Manhasset, NY 11030, USA.; To determine if cytomegalovirus ( CMV ) retinitis occurs more frequently in patients infected with certain strains CMV isolates from the blood of 44 patients with advanced human immunodeficiency virus disease were grouped by th
Low plasma concentrations achieved with conventional schedules of administration of ganciclovir in patients with AIDS.: J Infect Dis. 1996 Jul;174(1):188-90. Unique Identifier : AIDSLINE MED/96262012; Piketty C; Bardin C; Gilquin J; Mahe V; Kazatchkine MD; Chast F; Unite d'Immunologie Clinique, Hopital Broussais, Paris, France.; Plasma concentration of ganciclovir was studied prospectively in 15 AIDS patients treated for acute cytomegalovirus ( CMV ) retinitis. Ganciclovir was administered at a mean dose of 10.3 +/- 0.6 mg/kg/day. The mean trough plasm
Variation in plasma RNA levels, CD4 cell counts, and p24 antigen levels in clinically stable men with human immunodeficiency virus infection.: J Infect Dis. 1996 Jul;174(1):191-4. Unique Identifier : AIDSLINE MED/96262013; Raboud JM; Montaner JS; Conway B; Haley L; Sherlock C; O'Shaughnessy MV; Schechter MT; Department of Health Care and Epidemiology, University of British; Columbia, Canada.; Short-term variability in CD4 cell counts, plasma RNA levels, and p24 antigenemia was measured in clinically stable men with human immunodeficiency virus infection. Blood samples were obtained three times in each of 2 weeks 4 weeks apart. Differences between duplicate assays were considered to be due to technical fact
Primary infection with zidovudine-resistant human immunodeficiency virus type 1 does not adversely affect outcome at 1 year. Sydney Primary HIV Infection Study Group.: J Infect Dis. 1996 Jul;174(1):195-8. Unique Identifier : AIDSLINE MED/96262014; Imrie A; Carr A; Duncombe C; Finlayson R; Vizzard J; Law M; Kaldor J; Penny R; Cooper DA; Centre for Immunology, St Vincent's Hospital, Sydney, Australia.; Human immunodeficiency virus type 1 (HIV-1) variants with reduced in vitro sensitivity to zidovudine, conferred by specific mutations in the viral reverse transcriptase, emerge during prolonged therapy. Late-stage disease and declining CD4 cell count are associated with more rapid emergence of these resistant variants
Pseudouridine and 1-ribosylpyridin-4-one-3-carboxamide (PCNR) serum concentrations in human immunodeficiency virus type 1-infected patients are independent predictors for AIDS progression.: J Infect Dis. 1996 Jul;174(1):199-203. Unique Identifier : AIDSLINE MED/96262015; Intrieri M; Calcagno G; Oriani G; Pane F; Zarrilli F; Cataldo PT; Foggia M; Piazza M; Salvatore F; Sacchetti L; Dipartimento di Biochimica e Biotecnologie Mediche, Universita; degli Studi di Napoli, Federico II, Italy.; A prospective study was conducted with 161 human immunodeficiency virus (HIV)-positive patients to investigate the prognostic role of 10 serum-modified nucleosides with regard to some of the most widely used parameters of AIDS progression. Serum concentrations of pseudouridine (> 3.77 nmol/mL) predicted progression to
Treatment of human immunodeficiency virus infection with hydroxyurea: virologic and clinical evaluation.: J Infect Dis. 1996 Jul;174(1):204-9. Unique Identifier : AIDSLINE MED/96262016; Giacca M; Zanussi S; Comar M; Simonelli C; Vaccher E; de Paoli P; Tirelli U; International Centre for Genetic Engineering and Biotechnology,; Trieste, Italy.; To assess the efficacy of the therapeutic use of inhibitors of ribonucleotide reductase for the treatment of human immunodeficiency virus (HIV) type 1 infection, 7 consecutive patients were enrolled in a clinical trial involving monotherapy with hydroxyurea for 8-19 weeks. During therapy, patients were evaluated for c
Lysis of human immunodeficiency virus type 1 antigen-expressing cells by CD4 and CD8 T cells ex vivo.: J Infect Dis. 1996 Jul;174(1):209-13. Unique Identifier : AIDSLINE MED/96262017; Heinkelein M; Euler-Konig I; Klinker H; Ruckle-Lanz H; Jassoy C; Department of Internal Medicine, and Medical Policlinic,; University of Wurzburg, Germany.; The aim of this study was to investigate the extent of lysis mediated by cytotoxic T lymphocytes (CTL) directed against human immunodeficiency virus (HIV) type 1 gag protein and envelope glycoprotein in peripheral blood mononuclear cells (PBMC) from HIV-1-infected subjects and to compare it with nonspecific envelope g
In vitro inhibition of the replication of human immunodeficiency virus type 1 by beta-mercaptoethylamine (cysteamine).: J Infect Dis. 1996 Jul;174(1):214-8. Unique Identifier : AIDSLINE MED/96262018; Bergamini A; Ventura L; Mancino G; Capozzi M; Placido R; Salanitro A; Cappannoli L; Faggioli E; Stoler A; Rocchi G; Department of Public Health and Cellular Biology, University of; Rome, Tor Vergata, Italy.; This study investigates the effects of cysteamine alone and in association with zidovudine or didanosine on the replication of human immunodeficiency virus type 1 (HIV-1). More than 90% viral inhibition was obtained by 200 microM cysteamine in lymphocytes and 100 microM cysteamine in macrophages against 4 primary isol
Diagnosis of neurosyphilis in patients infected with human immunodeficiency virus type 1.: J Infect Dis. 1996 Jul;174(1):219-21. Unique Identifier : AIDSLINE MED/96262019; Marra CM; Gary DW; Kuypers J; Jacobson MA; Department of Neurology, University of Washington, Seattle, USA.; Establishing the diagnosis of neurosyphilis may be particularly difficult in human immunodeficiency virus type 1 (HIV)-infected persons. Polymerase chain reaction (PCR) was used to detect Treponema pallidum DNA in cerebrospinal fluid (CSF) from 81 HIV-infected patients. On the basis of reactive serum and CSF-VDRL test
Iron overload as a mechanism for the lowered survival in AIDS patients receiving dapsone-iron protoxalate for secondary prophylaxis of Pneumocystis carinii pneumonia [letter; comment]: J Infect Dis. 1996 Jul;174(1):241-2. Unique Identifier : AIDSLINE MED/96262026; Weinberg GA
The changing epidemiology of pneumococcal bacteremia in human immunodeficiency virus infection [letter]: J Infect Dis. 1996 Jul;174(1):242-4. Unique Identifier : AIDSLINE MED/96262027; Earhart KC; Wallace MR
False-negative polymerase chain reaction-based diagnosis of human immunodeficiency virus (HIV) type 1 in children infected with HIV strains of African origin [letter; comment]: J Infect Dis. 1996 Jul;174(1):244-5. Unique Identifier : AIDSLINE MED/96262028; Haas J; Geiss M; Bohler T
No evidence for a role of enteroadherent Escherichia coli in diarrhea in human immunodeficiency virus-infected patients [letter]: J Infect Dis. 1996 Jul;174(1):246. Unique Identifier : AIDSLINE MED/96262029; Schultsz C; Snijders F; Dankert J
Factors influencing human immunodeficiency virus type 1 transmission by blood transfusion. Transfusion Safety Study Group.: J Infect Dis. 1996 Jul;174(1):26-33. Unique Identifier : AIDSLINE MED/96261990; Busch MP; Operskalski EA; Mosley JW; Lee TH; Henrard D; Herman S; Sachs DH; Harris M; Huang W; Stram DO; Irwin Memorial Blood Centers, University of California, San; Francisco, USA.; One hundred thirty-two recipients of blood components that retrospectively tested positive for antibody to human immunodeficiency virus type 1 (anti-HIV-1) were identified. Fourteen (11%) remained seronegative throughout follow-up. Donor and recipient characteristics that could have influenced transmission were examin
Human immunodeficiency virus type 1 (HIV-1)--and Epstein-Barr virus--specific cytotoxic T lymphocyte precursors exhibit different kinetics in HIV-1--infected persons.: J Infect Dis. 1996 Jul;174(1):34-45. Unique Identifier : AIDSLINE MED/96261991; Geretti AM; Dings ME; van Els CA; van Baalen CA; Wijnholds FJ; Borleffs JC; Osterhaus AD; Institute of Virology, Erasmus University Rotterdam, Netherlands.; The frequencies of human immunodeficiency virus type 1 (HIV-1) Gag- and Epstein-Barr virus (EBV)-specific cytotoxic T lymphocyte precursors (CTLp) were studied longitudinally in peripheral blood mononuclear cells from 9 HIV-1-infected persons. By antigen-specific stimulation, HIV-1 Gag-specific CTLp were detected in v
Molecular analysis of decreased interleukin-12 production in persons infected with human immunodeficiency virus.: J Infect Dis. 1996 Jul;174(1):46-53. Unique Identifier : AIDSLINE MED/96261992; Chougnet C; Wynn TA; Clerici M; Landay AL; Kessler HA; Rusnak J; Melcher GP; Sher A; Shearer GM; Experimental Immunology Branch, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892-1360,; USA.; Human immunodeficiency virus (HIV) disease is associated with loss of type 1 responses, including interleukin (IL)-12 production. The dramatic drop in p70 production seen at early stages of disease was found not to be associated with a similarly decreased p40 mRNA expression. p35 mRNA expression was more extensively r
Engagement of adhesion molecules (CD18, CD11a, CD45, CD44, and CD58) enhances human immunodeficiency virus type 1 replication in monocytic cells through a tumor necrosis factor-modulated pathway.: J Infect Dis. 1996 Jul;174(1):54-62. Unique Identifier : AIDSLINE MED/96261993; Shattock RJ; Rizzardi GP; Hayes P; Griffin GE; Division of Infectious Diseases, St. George's Hospital Medical; School, London, United Kingdom.; Engagement of monocytic cell membrane proteins was shown to enhance human immunodeficiency virus type 1 (HIV-1) replication in monocytic cells. Cross-linking of CD18, CD11a, or CD45 by immobilized antibodies produced up to an 11-fold enhancement of HIV-1 release in the OM10.1 monocytic cell line in a tumor necrosis fa
Inhibition of immunoreactive tumor necrosis factor-alpha by a chimeric antibody in patients infected with human immunodeficiency virus type 1.: J Infect Dis. 1996 Jul;174(1):63-8. Unique Identifier : AIDSLINE MED/96261994; Walker RE; Spooner KM; Kelly G; McCloskey RV; Woody JN; Falloon J; Baseler M; Piscitelli SC; Davey RT Jr; Polis MA; Kovacs JA; Masur H; Lane HC; National Institute of Allergy and Infectious Diseases, Critical; Care Medicine Department, National Institutes of Health,; Bethesda, MD 20892, USA.; Tumor necrosis factor-alpha (TNF-alpha), a proinflammatory cytokine known to stimulate human immunodeficiency virus type 1 (HIV-1) replication, has been implicated in the pathogenesis of HIV-1 infection. Inhibition of TNF-alpha by a chimeric humanized monoclonal antibody, cA2, was investigated in 6 HIV-1-infected pati
Adenosine deaminase isoenzymes and pleural tuberculosis [editorial; comment]: J Lab Clin Med. 1996 Apr;127(4):326-7. Unique Identifier : AIDSLINE MED/96202697; Antony VB
The lectin jacalin triggers CD4-mediated lymphocyte signaling by binding CD4 through a protein-protein interaction.: J Leukoc Biol. 1996 May;59(5):691-6. Unique Identifier : AIDSLINE MED/96239300; Lafont V; Dornand J; Covassin L; Liautard JP; Favero J; Institut National de la Sante et de la Recherche Medicale,; Department de Biologie Sante, Universite de Montpellier II,; France.; The lectin jacalin specifically stimulates lymphocytes expressing the CD4 antigen. Recent studies have also demonstrated that this lectin interacts with CD4, inhibits in vitro HIV infection, and triggers cell signaling directly via CD4. Jacalin as a lectin was suggested to trigger CD4-mediated cell signaling by intera
The relationship of HIV status, type of coagulation disorder, and school absenteeism to cognition, educational performance, mood, and behavior of boys with hemophilia.: J Genet Psychol. 1996 Jun;157(2):137-51. Unique Identifier : AIDSLINE MED/96241891; Mayes SD; Handford HA; Schaefer JH; Scogno CA; Neagley SR; Michael-Good L; Pelco LE; Department of Psychiatry, College of Medicine, Pennsylvania State; University, USA.; Psychological and educational data were analyzed for all school-aged males with hemophilia at the Hemophilia Center of Central Pennsylvania (N = 66). Mean IQ (113.5) was higher than normal, and 2.4 times as many boys with hemophilia were enrolled in gifted programming than is the state average for boys. However, there
Basic research plays a key role in new patient treatments [news]: J Natl Cancer Inst. 1996 Jul 3;88(13):869. Unique Identifier : AIDSLINE MED/96264987; Law C
Serum HIV-1 RNA levels and time to development of AIDS in the Multicenter Hemophilia Cohort Study.: JAMA. 1996 Jul 10;276(2):105-10. Unique Identifier : AIDSLINE MED/96272949; O'Brien TR; Blattner WA; Waters D; Eyster E; Hilgartner MW; Cohen AR; Luban N; Hatzakis A; Aledort LM; Rosenberg PS; Miley WJ; Kroner BL; Goedert JJ; Viral Epidemiology Branch, National Cancer Institute, Rockville,; MD 20852, USA.; OBJECTIVE--To determine if the long-term incidence of the acquired immunodeficiency syndrome (AIDS) is related to human immunodeficiency virus type 1 (HIV-1) RNA levels measured early in HIV-1 infection. DESIGN--Epidemiologic cohort study. SETTING--Five hemophilia treatment centers in the
Safety and efficacy of lamivudine-zidovudine combination therapy in zidovudine-experienced patients. A randomized controlled comparison with zidovudine monotherapy. Lamivudine European HIV Working Group.: JAMA. 1996 Jul 10;276(2):111-7. Unique Identifier : AIDSLINE MED/96272950; Staszewski S; Loveday C; Picazo JJ; Dellarnonica P; Skinhoj P; Johnson MA; Danner SA; Harrigan PR; Hill AM; Verity L; McDade H; Klinikum der Johann Wolfgang Goethe Universitat, Frankturt,; Germany.; OBJECTIVE--To compare the safety and efficacy of 2 doses of lamivudine given in combination with zidovudine with continued zidovudine monotherapy. DESIGN--Double-blind, randomized, multicenter, comparative trial of 223 patients treated for 24 weeks. SETTING--Patients from 32 hospitals in Europe were enrolled throughou
Safety and efficacy of lamivudine-zidovudine combination therapy in antiretroviral-naive patients. A randomized controlled comparison with zidovudine monotherapy. Lamivudine European HIV Working Group.: JAMA. 1996 Jul 10;276(2):118-25. Unique Identifier : AIDSLINE MED/96272951; Katlama C; Ingrand D; Loveday C; Clumeck N; Mallolas J; Staszewski S; Johnson M; Hill AM; Pearce G; McDade H; Hospitalier Pitie Salpetriere, Paris, France.; OBJECTIVE--To compare safety and efficacy of lamivudine-zidovudine combination therapy with zidovudine monotherapy in treating human immunodeficiency virus type 1 (HIV-1)-infected, antiretroviral therapy-naive patients. DESIGN--Double-blind, randomized, multicenter, co
Prevalence of HIV infection in the United States, 1984 to 1992.: JAMA. 1996 Jul 10;276(2):126-31. Unique Identifier : AIDSLINE MED/96272952; Karon JM; Rosenberg PS; McQuillan G; Khare M; Gwinn M; Petersen LR; Division of HIV/AIDS Prevention Centers for Disease Control and; Prevention, Atlanta, GA 30333, USA.; OBJECTIVE--To estimate the number of persons infected with the human immunodeficiency virus (HIV) living in the United States and the change in HIV infection prevalence since 1984. DESIGN--We estimated HIV prevalence from 3 data sources. We estimated past HIV infection rates from a sta
Economic impact of treatment of HIV-positive pregnant women and their newborns with zidovudine. Implications for HIV screening.: JAMA. 1996 Jul 10;276(2):132-8. Unique Identifier : AIDSLINE MED/96272953; Mauskopf JA; Paul JE; Wichman DS; White AD; Tilson HH; Glaxo Welcome Inc., Research Triangle Park, NC 27709, USA.; OBJECTIVES--To estimate the economic impact of (1) treating pregnant women who are human immunodeficiency virus (HIV)-positive with zidovudine and (2) voluntary screening programs for pregnant women for HIV infection and offering treatment with zidovudine to those found to be HIV-positive. MAIN OUTCOME MEASURES--Numbe
Cost-effectiveness of short-course zidovudine to prevent perinatal HIV type 1 infection in a sub-Saharan African Developing country setting.: JAMA. 1996 Jul 10;276(2):139-45. Unique Identifier : AIDSLINE MED/96272954; Mansergh G; Haddix AC; Steketee RW; Nieburg PI; Hu DJ; Simonds RJ; Rogers M; Epidemiology Branch, NCHSTP, MSE-45, Centers for Disease Control; and Prevention, Atlanta, GA 30333, USA.; OBJECTIVE--To evaluate the cost-effectiveness of a short-course zidovudine program to prevent perinatal transmission of human immunodeficiency virus (HIV) type 1 in sub-Saharan African country settings. DESIGN AND SETTING--Several clinical trials of short-course zidovudine during pregnancy for prevention of perinatal
Antiretroviral therapy for HIV infection in 1996. Recommendations of an international panel. International AIDS Society-USA.: JAMA. 1996 Jul 10;276(2):146-54. Unique Identifier : AIDSLINE MED/96272955; Carpenter CC; Fischl MA; Hammer SM; Hirsch MS; Jacobsen DM; Katzenstein DA; Montaner JS; Richman DD; Saag MS; Schooley RT; Thompson MA; Vella S; Yeni PG; Volberding PA; Brown University School of Medicine, Providence, RI, USA.; OBJECTIVE--To provide clinical recommendations for antiretroviral therapy for human immunodeficiency virus (HIV) disease with currently (mid 1996) available drugs. When to start therapy, what to start with, when to change, and what to change to were addressed. PARTICIPANTS--A 13-member panel representing international
AIDS in 1996. Much accomplished, much to do [editorial]: JAMA. 1996 Jul 10;276(2):155-6. Unique Identifier : AIDSLINE MED/96272956; Fauci AS
Importance of surrogate markers in evaluation of antiviral therapy for HIV infection.: JAMA. 1996 Jul 10;276(2):159-60. Unique Identifier : AIDSLINE MED/96272957; Deyton L; HIV Research Branch, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Surrogate markers in AIDS research. Is there truth in numbers?: JAMA. 1996 Jul 10;276(2):161-2. Unique Identifier : AIDSLINE MED/96272958; Levy JA; Cancer Research Institute, University of California, San; Francisco, School of Medicine, USA.
Issue dedicated to HIV/AIDS research.: JAMA. 1996 Jul 10;276(2):85-162. Unique Identifier : AIDSLINE MED/96294677
HIV guide for primary care physicians stresses patient-centered prevention [news]: JAMA. 1996 Jul 10;276(2):85-6. Unique Identifier : AIDSLINE MED/96272931; Voelker R
Penicillium marneffei part of Southeast Asian AIDS [news]: JAMA. 1996 Jul 10;276(2):86-7. Unique Identifier : AIDSLINE MED/96272932; Phillips P
From the Centers for Disease Control and Prevention. Update: provisional public health service recommendations for chemoprophylaxis after occupational exposure to HIV.: JAMA. 1996 Jul 10;276(2):90-2. Unique Identifier : AIDSLINE MED/96272935
The changing face of AIDS in Argentina.: JAMA. 1996 Jul 10;276(2):94-6. Unique Identifier : AIDSLINE MED/96272937; Betts CD; Astarloa L; Bloch C; Zacarias F; Chelala C; National Program Against Human Retrovirus and AIDS, Ministry of; Health and Social Action of Argentina, Buenos Aires.
A piece of my mind. Shadow bands.: JAMA. 1996 Jul 10;276(2):98. Unique Identifier : AIDSLINE MED/96272938; Lyons SF
Incidence of HIV infection in a New York City methadone maintenance treatment program [letter]: JAMA. 1996 Jul 10;276(2):99. Unique Identifier : AIDSLINE MED/96272939; Orr MF; Glebatis D; Friedmann P; des Jarlais DC; Prevots DR
Transmission of HIV-1 subtype E in the united states [letter]: JAMA. 1996 Jul 10;276(2):99-100. Unique Identifier : AIDSLINE MED/96272940; Artenstein AW; Ohl CA; VanCott TC; Hegerich PA; Mascola JR
HIV counseling and testing of pregnant women [letter]: JAMA. 1996 Jul 24-31;276(4):283-4. Unique Identifier : AIDSLINE MED/96286138; Phillips KA; Bleecker T; Morrison KR; Sonnad SS
[The role of some cellular components of bacterial parasites in determining the incidence of tuberculosis: studies on mycobacterial antigens, with special reference to mycobacterial immunoreactive ribosomal and secreted proteins]: Kekkaku. 1995 Nov;70(11):639-44. Unique Identifier : AIDSLINE MED/96111766; Yamada T; Ohara N; Matsumoto S; Matsuo T; Kitaura H; Yukitake H; Wada N; Nishiyama T; Naito M; Kinomoto M; et al; Nagasaki University, School of Dentistry, Japan.; Tuberculosis remains as major disease, affecting more than 20 million people. The elimination of the disease with vaccination, rapid diagnosis, and and efficient therapy is an important objective of our study. To realize the objective, the characterization of antigens is essential. We have chosen two kinds of antigens
[The mode of infection of tuberculosis--analysis using molecular epidemiologic methods]: Kekkaku. 1995 Nov;70(11):645-50. Unique Identifier : AIDSLINE MED/96111767; Abe C; Research Institute of Tuberculosis, Japan Anti-Tuberculosis; Association Matsuyama 3-1-24, Tokyo, Japan.; In the 1950 s, evidence showed that INH-resistant Mycobacterium tuberculosis organisms were attenuated in both virulence and pathogenicity in animals, and it was postulated that these bacilli might also be attenuated in their virulence to humans. Subsequent studies, however, indicated that all INH-resistant strains sh
[Clinical comparison of pulmonary tuberculosis with pulmonary M. avium complex disease]: Kekkaku. 1995 Nov;70(11):659-63. Unique Identifier : AIDSLINE MED/96111769; Suzuki K; Chest Disease Research Institute, Kyoto University, Japan.; At first, we reviewed radiographic findings of primary pulmonary tuberculosis, secondary pulmonary tuberculosis, pulmonary M. avium complex (MAC) disease without predisposing conditions, and pulmonary tuberculosis in AIDS patient. Infiltrates in lower field, mediastinal lymphadenopathy, and pleural effusion were the c
SF-20 score and item distributions in a human immunodeficiency virus-seropositive sample.: Med Care. 1996 Jun;34(6):562-9. Unique Identifier : AIDSLINE MED/96258356; Holmes W; Bix B; Shea J; Division of General Internal Medicine, Center for Clinical; Epidemiology and Biostatistics, University of Pennsylvania School; of Medicine, Philadelphia 19104-6021, USA.; The question of whether the full range of possible health states is measured by the Medical Outcomes Study (MOS) 20-Item Short-Form Health Survey (SF-20) in human immunodeficiency virus (HIV)-seropositive individuals is examined in this article. Ninety-five HIV-seropositive men (37 with asymptomatic infection, 58 with
Clinical predictors of functioning in persons with acquired immunodeficiency syndrome.: Med Care. 1996 Jun;34(6):610-23. Unique Identifier : AIDSLINE MED/96258360; Wilson IB; Cleary PD; Department of Medicine, New England Medical Center Hospitals,; Boston, MA, USA.; To help clinicians better assess and treat functional disabilities in persons with acquired immunodeficiency syndrome (AIDS), the authors estimate empirical relations among biologic and physiologic variables, symptoms, and physical functioning in persons with AIDS. The sample of 305 persons with AIDS for this cross-se
[Human gene therapy: trends and current problems]: Med Clin (Barc). 1996 Mar 30;106(12):469-76. Unique Identifier : AIDSLINE MED/96243280; Lazo PA; Unidad de Genetica Molecular (CSIC), Centro Nacional de; Biologia Celular y Retrovirus, Instituto de Salud Carlos III,; Majadahonda, Madrid.
[Disseminated Kaposi's sarcoma with hepatosplenic involvement in AIDS]: Med Clin (Barc). 1996 Apr 27;106(16):622-3. Unique Identifier : AIDSLINE MED/96243329; Gonzalez-Lopez A; Fernandez-Martin JI; Gordillo I; Dronda F; Unidad de Enfermedades Infecciosas-Microbiologia, Hospital; General Penitenciario, Madrid.; Kaposi sarcoma (KS) is the most frequent neoplasm found in AIDS patients. The disease is often disseminated and preferentially involves the skin and the lymphatic and digestive systems. Hepatosplenic involvement which is considered as a frequent autopsy finding is rarely diagnosed at life. A 27-year-old male HIV posit
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) for the treatment of human immunodeficiency virus type 1 (HIV-1) infections: strategies to overcome drug resistance development.: Med Res Rev. 1996 Mar;16(2):125-57. Unique Identifier : AIDSLINE MED/96249959; de Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
[A study of STD patients and their sexual behavior. Safer sex after interviews prior to journey abroad]: Lakartidningen. 1996 Feb 28;93(9):789-92. Unique Identifier : AIDSLINE MED/96248651; Ramstedt K; Karlsson AC; Lundin L; Hallhagen G; Toshach B; Smittskyddsinstitutet, Stockholm.
Transmission of HIV-1 by human bite [letter]: Lancet. 1996 Jun 22;347(9017):1762. Unique Identifier : AIDSLINE MED/96256427; Vidmar L; Poljak M; Tomazic J; Seme K; Klavs I
No relationship between HTLV-1 infection and filariasis--Serological study on patients with filariasis in Recife, Brazil.: Microbiol Immunol. 1995;39(11):917-9. Unique Identifier : AIDSLINE MED/96245553; Linhares MI; Malagueno E; Carvalho LB Jr; de Oliveira VF; Minamishima Y; Laboratorio de Imunopatologia Keizo Asami, Universidade Federal; de Pernambuco, Recife, Brazil.; The seroprevalence of antibodies against human T-cell leukemia virus was determined by ELISA in 68 patients with filarial infestation living in an endemic area. The total seropositivity was 2.9% and the HTLV-1-positive cases were detected in 2 microfilaremic patients 12 and 40 years old. This value is very close to th
Managing HIV. Part 6: People living with HIV. 6.1 Men and HIV.: Med J Aust. 1996 Jun 3;164(11):666-8. Unique Identifier : AIDSLINE MED/96257304; Pethebridge AM; Plummer DC; National Centre for Epidemiology and Population Health,; Australian National University, Canberra.; The medical management of the HIV-infected man is covered throughout Managing HIV. Understanding the sexuality of men is a crucial factor in understanding the HIV pandemic.
Managing HIV. Part 6: People living with HIV. 6.2 Women with HIV.: Med J Aust. 1996 Jun 3;164(11):669-71. Unique Identifier : AIDSLINE MED/96257305; Mijch AM; Clezy K; Furner V; Fairfield Hospital, Melbourne, VIC, NSW.; Gay men with HIV often belong to strong mutually supportive groups, but many women with HIV experience the disease in relative isolation. Informed primary care doctors can make a valuable difference to their management.
Managing HIV. Part 6: People living with HIV. 6.3 Children with HIV.: Med J Aust. 1996 Jun 3;164(11):672-9. Unique Identifier : AIDSLINE MED/96257306; Ziegler JB; Blanche S; Loh R; Department of Immunology and Allergy, Sydney Children's Hospital,; NSW.; Sometimes the diagnosis of HIV in a child is the first sign that other family members are affected by the virus. The immature immune system of children responds to HIV infection differently to that of adults. Disease progression is rapid in some, but most progress to AIDS at a similar or slower rate than do adults. A
['95 pneumology update. Progress and prospects in pneumology. Paradigm of change--II]: Med Klin. 1996 Apr 1;91 Suppl 1:103-17. Unique Identifier : AIDSLINE MED/96222202; Kroegel C; Buhl R; Muller-Querheim J; Wertzel H; Rabe K; Swoboda L; Matthys H; Hasse J; Magnussen H; Virchow JC; Abteilung Pneumologie, Medizinische Kliniken,; Albert-Ludwigs-Universitat, Freiburg.
[Clinical infectiology--I. Diagnosis, pathogen spectrum and resistance]: Med Klin. 1996 Apr 1;91 Suppl 1:166-75. Unique Identifier : AIDSLINE MED/96222208; Schrappe M; Medizinische Klinik I, Universitat Koln.
[Gastroenterology update]: Med Klin. 1996 Apr 1;91 Suppl 1:65-71. Unique Identifier : AIDSLINE MED/96222198; Layer P; Grandt D; Goebell H; Abteilung fur Gastroenterologie, Medizinische; Universitatsklinik, Essen.
[1995 gastroenterology update--I]: Med Klin. 1996 Apr 1;91 Suppl 1:73-80. Unique Identifier : AIDSLINE MED/96222199; Layer P; Brambs HJ; Ell C; Fischbach W; Fleig WE; Scholmerich J; Zirngibl H; Abteilung fur Gastroenterologie, Universitatsklinikum, Essen.
A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes.: Mol Cell Biol. 1996 Apr;16(4):1283-94. Unique Identifier : AIDSLINE GENBANK/D78261; Yamagata T; Nishida J; Tanaka S; Sakai R; Mitani K; Yoshida M; Taniguchi T; Yazaki Y; Hirai H; Third Department of Internal Medicine, Tokyo University, Japan.; We have isolated a novel cDNA clone encoding interferon (IFN) consensus sequence-binding protein in adult T-cell leukemia cell line or activated T cells (ICSAT); this protein is the human homolog of the recently cloned Pip/LSIRF. ICSAT is structurally most closely related to the previously cloned ICSBP, a member of th
Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability.: Mol Cell Biol. 1996 Apr;16(4):1401-9. Unique Identifier : AIDSLINE MED/96239494; Lin R; Beauparlant P; Makris C; Meloche S; Hiscott J; Lady Davis Institute for Medical Research, Sir Mortimer B. Davis; Jewish General Hospital, Montreal, Quebec, Canada.; The NF-kappaB/Rel transcription factors participate in the activation of immune system regulatory genes and viral early genes including the human immunodeficiency virus type 1 long terminal repeat. NF-kappaB/Rel proteins are coupled to inhibitory molecules, collectively termed IkappaB, which are responsible for cytopl
Role of polyadenylation in nucleocytoplasmic transport of mRNA.: Mol Cell Biol. 1996 Apr;16(4):1534-42. Unique Identifier : AIDSLINE MED/96239508; Huang Y; Carmichael GC; Department of Microbiology, University of Connecticut Health; Center, Farmington, 06030, USA.; To examine the role of polyadenylation in the nuclear export of mRNA, we have replaced the poly(A) signal in a Rev-responsive human immunodeficiency virus type 1-based reporter gene with a cis-acting hammerhead ribozyme. Transcripts from this gene thus acquire a 3 terminus by cis-ribozyme cleavage rather than by poly
Transcriptional activation of RNA polymerase III-dependent genes by the human T-cell leukemia virus type 1 tax protein.: Mol Cell Biol. 1996 Apr;16(4):1777-85. Unique Identifier : AIDSLINE MED/96239534; Gottesfeld JM; Johnson DL; Nyborg JK; Department of Molecular Biology, The Scripps Research Institute,; La Jolla, California 92037, USA.; The human T-cell leukemia virus-encoded tax protein is a potent activator of many viral and cellular genes transcribed by RNA polymerase II. We find that both chromatin and cell extracts derived from human T-cell leukemia virus type 1-infected human T lymphocytes support higher levels of 5S rRNA and tRNA gene transcri
Seroconversion to antibodies against Kaposi's sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi's sarcoma.: N Engl J Med. 1996 Jul 25;335(4):233-41. Unique Identifier : AIDSLINE MED/96266385; Gao SJ; Kingsley L; Hoover DR; Spira TJ; Rinaldo CR; Saah A; Phair J; Detels R; Parry P; Chang Y; Moore PS; Division of Epidemiology, School of Public Health, Columbia; University, New York, NY 10032, USA.; BACKGROUND: If Kaposi s sarcoma-associated herpesvirus (KSHV) is the cause of Kaposi s sarcoma, serologic evidence of infection should be present in patients before the disease develops. METHODS: Using an immunoblot assay for two latent nuclear antigens of KSHV, we tested serum samples from homosexual male patients wi
A drumstick? [letter]: N Engl J Med. 1996 Jul 25;335(4):291. Unique Identifier : AIDSLINE MED/96266409; Kessler L
WW domains and retrovirus budding [letter]: Nature. 1996 Jun 27;381(6585):744-5. Unique Identifier : AIDSLINE MED/96267000; Garnier L; Wills JW; Verderame MF; Sudol M
HIV therapy--what's new? [letter]: N Z Med J. 1996 May 10;109(1021):172. Unique Identifier : AIDSLINE MED/96257331; Chew GS
Infected surgeons.: N Z Med J. 1996 May 24;109(1022):177-8. Unique Identifier : AIDSLINE MED/96257337
AIDS [news]: N Z Med J. 1996 May 24;109(1022):196. Unique Identifier : AIDSLINE MED/96257351
Extensive vascular calcification in a patient with perinatally acquired AIDS.: Pediatr Radiol. 1996;26(5):365-6. Unique Identifier : AIDSLINE MED/96270095; Marquis JR; D'Cruz C; Department of Radiology, Children's Hospital of New Jersey,; United Hospitals Medical Center, 15 South Ninth Street, Newark,; NJ 07107, USA.; Extensive vascular calcification in an 8-year-old girl with perinatally acquired AIDS is reported. Complicating factors included cardiomyopathy, chronic lung disease, disseminated Mycobacterium avium complex (MAC), and wasting syndrome with total nutrition dependence. Plain abdominal films and CT of the abdomen immedi
Combination therapy with stavudine and didanosine in children with advanced human immunodeficiency virus infection: pharmacokinetic properties, safety, and immunologic and virologic effects.: Pediatrics. 1996 Jun;97(6 Pt 1):886-90. Unique Identifier : AIDSLINE MED/96237970; Kline MW; Fletcher CV; Federici ME; Harris AT; Evans KD; Rutkiewicz VL; Shearer WT; Dunkle LM; Department of Pediatrics, Baylor College of Medicine, Houston, TX; 77030, USA.; OBJECTIVES. To obtain preliminary information on the pharmacokinetic properties, tolerance, safety, and antiviral activity of combination therapy with stavudine and didanosine in children with advanced
Varicella vaccination [letter]: Pediatrics. 1996 Jun;97(6 Pt 1):932. Unique Identifier : AIDSLINE MED/96237988; May DL
The basic domain/leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE-like sequences containing an ACGT core.: Nucleic Acids Res. 1996 May 15;24(10):1855-64. Unique Identifier : AIDSLINE MED/96226171; Clauss IM; Chu M; Zhao JL; Glimcher LH; Department of Cancer Biology, Harvard School of Public Health,; Boston, MA 02115-6023, USA.; The transcription factor hXBP-1 belongs to the family of basic region/leucine zipper (bZIP) proteins and interacts with the cAMP responsive element (CRE) of the major histocompatibility complex (MHC) class II A alpha, DR alpha and DP beta genes. However, the developmental expression of hXBP-1 as revealed by in situ hy
A nuclear matrix-specific factor that binds a specific segment of the negative regulatory element (NRE) of HIV-1 LTR and inhibits NF-kappa(B) activity.: Nucleic Acids Res. 1996 May 15;24(10):1895-900. Unique Identifier : AIDSLINE MED/96226176; Hoover T; Mikovits J; Court D; Liu YL; Kung HF; Raziuddin; Intramural Research Support Program, SAIC/Frederick, Frederick,; MD 21702-1201, USA.; The negative regulatory element (NRE) of human immunodeficiency virus type-1 (HIV-1) long terminal repeat (LTR) is a defined region that has been reported to downregulate LTR-directed HIV gene expression. However, information on the precise role of this region in regulating HIV gone transcription is lacking. We have i
Fusion with an RNA binding domain to confer target RNA specificity to an RNase: design and engineering of Tat-RNase H that specifically recognizes and cleaves HIV-1 RNA in vitro.: Nucleic Acids Res. 1996 May 15;24(10):1908-12. Unique Identifier : AIDSLINE MED/96226178; Melekhovets YF; Joshi S; Department of Microbiology, Faculty of Medicine, University of; Toronto, Ontario, Canada.; A target RNA/DNA-specific nuclease could be constructed if a specific RNA/DNA binding domain allowing target RNA/DNA recognition was fused to a (deoxy)ribonucleolytic domain allowing target RNA/ DNA cleavage. The design and construction of such a chimeric enzyme could be of value for both basic research involving stru
[Cytokines in persons infected with HIV and patients with AIDS]: Postepy Hig Med Dosw. 1995;49(1):125-35. Unique Identifier : AIDSLINE MED/96254191; Piasecki E; The cytokine system is affected by human immunodeficiency virus. The virus stimulates or inhibits the production of various cytokines. On the other hand, many cytokines may interfere with HIV replication. Interferons (mainly alpha- and beta-type) inhibit and tumor necrosis factors stimulate the virus replication in vi
[Use of anti-H-Y/Db transgenic mice in studies on T-lymphocyte development and mechanisms of leukemogenesis]: Postepy Hig Med Dosw. 1995;49(1):61-5. Unique Identifier : AIDSLINE MED/96254184; Matuszyk J; Laboratorium Immunologii Komorkowej.; During the development of T cells in the thymus, the alpha beta T-cell receptor (TCR) mediated interactions of immature CD4+ CD8+ cells with thymic major histocompatibility complex (MHC) molecules in the absence of specific antigens are required for their survival and further maturation (positive selection) whereas in
[Pentoxifylline]: Postepy Hig Med Dosw. 1995;49(2):201-20. Unique Identifier : AIDSLINE MED/96254198; Paradowski PT; Zeman K; Klinika Chirurgii Urazowej i Ortopedii Instytutu Chirurgii,; Szpital Kliniczny Wojskowej Akademii Medycznej w Lodzi.; Pentoxifylline (PTX), methylxanthine derivative and phosphodiesterase inhibitor, has been in use for more than 20 years (with minimal side effects) for the potent hemorrheologic properties and was recently discovered to have influence on function of some immune cells and production of cytokines. Human and animal studi
[Biological properties and therapeutic use of interleukin 2 (IL-2)]: Postepy Hig Med Dosw. 1995;49(3):367-93. Unique Identifier : AIDSLINE MED/96254208; Robak T; II Klinika Chorob Wewnetrznych Akademii Medycznej w Lodzi.; A cytokine produced by the subpopulation of activated helper lymphocytes T has been called interleukin-2 ( IL-2 ). The obtaining of recombinant cytokine has facilitated the study of its biological properties and its application in the treatment of certain neoplastic and
[Tuberculosis in patients with HIV infections and AIDS]: Probl Tuberk. 1996;(2):16-7. Unique Identifier : AIDSLINE MED/96222214; Alekseeva LP; Gorbacheva ES; Gruzdev VM; As shown by tuberculosis screening in HIV-infected and AIDS subjects performed in the Moscow Anti-AIDS Center from 1989-1994, tuberculosis morbidity in the above subjects is 17.3 per 1,000. Mean age of the tuberculosis subjects was 34 years. Most of them were males with acute generalized pulmonary tuberculosis which c
[Extra meningeal cryptococcosis in a patient with AIDS]: Rev Med Chil. 1995 Aug;123(8):1009-12. Unique Identifier : AIDSLINE MED/96195979; Srur E; Misad C; Henriquez A; Servicio de Medicina, Hospital San Juan de Dios, Santiago de; Chile.; We report a young homosexual male with AIDS that presented a systemic Cryptococcus neoformans infection. He had skin, lymph node and colonic involvement but the central nervous system was spared. Treatment was started with amphotericin B, achieving a good remission of skin lesions. However, malaise and digestive sympt
[Resisting AIDS?]: Rev Med Suisse Romande. 1996 Mar;116(3):229-30. Unique Identifier : AIDSLINE MED/96234642; Bonard EC
Murine acariasis. II. Immunological dysfunction and evidence for chronic activation of Th-2 lymphocytes.: Scand J Immunol. 1996 Jun;43(6):604-12. Unique Identifier : AIDSLINE MED/96257892; Jungmann P; Freitas A; Bandeira A; Nobrega A; Coutinho A; Marcos MA; Minoprio P; Unite d'Immunobiologie, CNRS URA 1961 and 1960, Institut; Pasteur, Paris, France.; The authors describe the immunological profile of BALB/c mice with Mite-Associated Ulcerative Dermatitis (MAUD)-like disease, due to Myocoptes musculinus (Koch 1844) infestation. The disease probably involves allergic mechanisms and is characterized by erythematous and pruritic skin lesions, widespread hair loss, lymp
Heterogeneous expression of recombination activating genes and surface CD5 in CD3low CD4+ CD8+ thymocytes.: Scand J Immunol. 1996 Jun;43(6):619-25. Unique Identifier : AIDSLINE MED/96257894; Sheard M; Sugaya K; Furuta M; Tsuda S; Takahama Y; Masaryk Memorial Cancer Institute, Brno, Czech Republic.; Clonal selection in the thymus occurs mostly in the CD4+ CD8+ (double positive; DP) stage. Within DP thymocytes, cells in the CD3low subset are believed to be involved in clonal selection, and this subset is generally considered as a homogeneous population. T-cell antigen-receptor (TCR) signals on DP thymocytes are kn
Activation of cloned human CD4+ Th1 and Th2 cells by blood dendritic cells.: Scand J Immunol. 1996 Jun;43(6):646-51. Unique Identifier : AIDSLINE MED/96257898; Roth R; Spiegelberg HL; Department of Pediatrics, University of California at San Diego,; School of Medicine, La Jolla 92093-0609, USA.; Dendritic cells (DC) have been reported to be the most potent antigen-presenting cells (APC) for the activation of naive T cells and to be 10-100-fold more potent APC than monocytes (M phi) in the mixed lymphocyte reaction. In this study the authors compared human blood DC with M phi and B cells for their ability to a
The effects of mitogens, IL-2 and anti-CD3 antibody on the T-cell receptor V beta repertoire.: Scand J Immunol. 1996 Jun;43(6):652-61. Unique Identifier : AIDSLINE MED/96257899; Jason J; Inge KL; Immunology Branch, Centers for Disease Control and Prevention; (CDC), Atlanta 30333, USA.; Phytohaemagglutinin (PHA), Concanavalin A (Con A), interleukin-2 ( IL-2 ), and monoclonal antibodies to CD3 (CD3MoAbs) are used for the assessment of the T-cell receptor (TCR) BV gene family expression in autoimmune disorders and multiple sclerosis, and to produce clones
Prevalence and determinants of anti-HCV seropositivity and of HCV genotype among intravenous drug users in Berlin.: Scand J Infect Dis. 1995;27(4):331-7. Unique Identifier : AIDSLINE MED/96108296; Stark K; Schreier E; Muller R; Wirth D; Driesel G; Bienzle U; Institute of Tropical Medicine, Free University, Berlin, Germany.; A cross-sectional study was carried out to identify risk factors for seropositivity for antibodies against hepatitis C virus (HCV) and to assess to the distribution and determinants of HCV genotypes among intravenous drug users (IVDUs). The study population consisted of 405 IVDUs. Serum specimens were tested for serom
Coxiella burnetii infection in subjects with HIV infection and HIV infection in patients with Q fever.: Scand J Infect Dis. 1995;27(4):344-6. Unique Identifier : AIDSLINE MED/96108298; Montes M; Cilla G; Marimon JM; Diaz de Tuesta JL; Perez-Trallero E; Servicio de Microbiologia y Unidad de Epidemiologia Infecciosa,; Facultad de Medicina, Hospital NS Aranzazu, San Sebastian,; Spain.; The objective of the study was to determine whether HIV infection favors the acquisition of Coxiella burnetii infection or increases the frequency of symptomatic Coxiella infections. A total of 754 subjects were tested for Coxiella antibodies: 596 intravenous drug users (IVDUs) (306 HIV-infected IVDUs matched by aged
Persistent reduction in lung function after Pneumocystis carinii pneumonia in AIDS patients.: Scand J Infect Dis. 1995;27(4):351-5. Unique Identifier : AIDSLINE MED/96108300; Nelsing S; Jensen BN; Backer V; Department of Infectious Diseases, Rigshospitalet, Copenhagen,; Denmark.; By means of serial lung function tests we examined the changes in lung function and possible pulmonary long-term sequelae in AIDS patients with a primary episode of Pneumocystis carinii pneumonia (PCP). A total of 19 patients had lung function tests performed prospectively from the time of PCP diagnosis, at 7 days, 14
Pneumocystis carinii in bronchoalveolar lavage and induced sputum: detection with a nested polymerase chain reaction.: Scand J Infect Dis. 1995;27(4):363-7. Unique Identifier : AIDSLINE MED/96108302; Skot J; Lerche AG; Kolmos HJ; Nielsen JO; Mathiesen LR; Lundgren JD; Department of Infectious Diseases, University of Copenhagen,; Hvidovre Hospital, Denmark.; To evaluate polymerase chain reaction (PCR) for detection of Pneumocystis carinii, 117 bronchoalveolar lavage (BAL) specimens, from HIV-infected patients undergoing a diagnostic bronchoscopy, were processed and a nested PCR, followed by Southern blot and hybridization with a P32-labelled probe was performed. The sensi
Oral Candida albicans isolates with reduced susceptibility to fluconazole in Swedish HIV-infected patients.: Scand J Infect Dis. 1995;27(4):391-5. Unique Identifier : AIDSLINE MED/96108307; Chryssanthou E; Torssander J; Petrini B; Department of Clinical Microbiology, Karolinska Hospital,; Stockholm, Sweden.; A total of 62 patients with HIV-related conditions were examined for clinical and mycological oral findings. Cultures from 51 patients were positive for yeasts and included 49 Candida albicans and 8 non-albicans isolates. Of patients with positive culture, 35% had pseudomembranous
Progressive intractable actinomycosis in patients with AIDS.: Scand J Infect Dis. 1995;27(4):405-7. Unique Identifier : AIDSLINE MED/96108311; Manfredi R; Mazzoni A; Marinacci G; Nanetti A; Chiodo F; Institute of Malattie Infettive, Universita di Bologna, Italy.; Two rare cases of progressive oropharyngeal actinomycosis, characterized by a subacute and invasive course despite seemingly appropriate antibiotic and surgical treatment, have been observed in patients with AIDS. A brief review of previously reported cases of actinomycosis in HIV-infected patients is presented. Clini
Tuberculous pericarditis in an HIV-infected patient.: Scand J Infect Dis. 1995;27(4):411-3. Unique Identifier : AIDSLINE MED/96108313; Antony SJ; Haas DW; Department of Medicine, Vanderbilt University School of Medicine,; Nashville, Tennessee 37232-2605, USA.; Persons co-infected with mycobacterium tuberculosis (MTB) and HIV are at increased risk for developing active tuberculosis. While extrapulmonary tuberculosis is particularly common in patients with AIDS, tuberculous pericarditis is a very uncommon complication of AIDS in the United States
[Side effects and consequences of frequently used antibiotics in clinical practice]: Schweiz Med Wochenschr. 1996 Mar 30;126(13):528-34. Unique Identifier : AIDSLINE MED/96214202; Cerny A; Departement Medizin, Inselspital Bern.; Oral antimicrobial substances belonging to the beta-lactams, quinolones, macrolides, tetracyclines and the trimethoprim-sulfamethoxazole combination are among the most prescribed classes of drugs in private practice. Knowledge of the potential side effects considered in the light of various patient-associated factors
The changing quality of life [news]: Sci Am. 1996 Jul;275(1):28. Unique Identifier : AIDSLINE MED/96285997; Doyle R
AIDS and circumcision [letter; comment]: Sci Am. 1996 Jul;275(1):8. Unique Identifier : AIDSLINE MED/96245452; Fleiss PM; Hodges F
AIDS and circumcision [letter; comment]: Sci Am. 1996 Jul;275(1):8. Unique Identifier : AIDSLINE MED/96245451; Padian N
Evidence of continuing risk of HIV transmission among injecting drug users from Dundee.: Scott Med J. 1996 Feb;41(1):3-4. Unique Identifier : AIDSLINE MED/96244228; Haw SJ; Higgins KM; Bell D; Johnston BB; Richardson AM; Royal Dundee Liff Hospital, Drug Problem Centre, Dundee,; Scotland.
AIDS: a global response [editorial]: Science. 1996 Jun 28;272(5270):1855. Unique Identifier : AIDSLINE MED/96275669; Piot P
The changing of the guard [news]: Science. 1996 Jun 28;272(5270):1876-9. Unique Identifier : AIDSLINE MED/96275676; Cohen J
The marketplace of HIV/AID$ [news]: Science. 1996 Jun 28;272(5270):1880-1. Unique Identifier : AIDSLINE MED/96275677; Cohen J
Protease inhibitors: a tale of two companies [news]: Science. 1996 Jun 28;272(5270):1882-3. Unique Identifier : AIDSLINE MED/96275678; Cohen J
Eradicating HIV from a patient: not just a dream? [news]: Science. 1996 Jun 28;272(5270):1884. Unique Identifier : AIDSLINE MED/96275679; Pennisi E; Cohen J
HIV receptors and the pathogenesis of AIDS.: Science. 1996 Jun 28;272(5270):1885-6. Unique Identifier : AIDSLINE MED/96275680; Weiss RA; Institute of Cancer Research, Chester Beatty Laboratories,; London, UK.
HIV therapeutics.: Science. 1996 Jun 28;272(5270):1886-8. Unique Identifier : AIDSLINE MED/96275681; Richman DD; San Diego Veterans Affairs Medical Center, La Jolla, California; 92092-0679, USA.
A perspective on AIDS vaccines.: Science. 1996 Jun 28;272(5270):1888-90. Unique Identifier : AIDSLINE MED/96275682; Bloom BR; Howard Hughes Medical Institute, Department of Microbiology,; Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Tickling memory T cells [comment]: Science. 1996 Jun 28;272(5270):1904. Unique Identifier : AIDSLINE MED/96275683; Ahmed R; Emory Vaccine Center, Emory University School of Medicine,; Atlanta, Georgia 30322, USA. holcombe@microbio.emory.edu
Antiviral effect and ex vivo CD4+ T cell proliferation in HIV-positive patients as a result of CD28 costimulation.: Science. 1996 Jun 28;272(5270):1939-43. Unique Identifier : AIDSLINE MED/96275689; Levine BL; Mosca JD; Riley JL; Carroll RG; Vahey MT; Jagodzinski LL; Wagner KF; Mayers DL; Burke DS; Weislow OS; St. Louis DC; June CH; Naval Medical Research Institute, Bethesda, Maryland 20889, USA.; Because stimulation of CD4+ lymphocytes leads to activation of human immunodeficiency virus-type 1 (HIV-1) replication, viral spread, and cell death, adoptive CD4+ T cell therapy has not been possible. When antigen and CD28 receptors on cultured T cells were stimulated by monoclonal antibodies (mAbs) to CD3 and CD28 t
Induction of bystander T cell proliferation by viruses and type I interferon in vivo [see comments]: Science. 1996 Jun 28;272(5270):1947-50. Unique Identifier : AIDSLINE MED/96275691; Tough DF; Borrow P; Sprent J; Department of Immunology, Scripps Research Institute, La Jolla,; California 92037, USA.; T cell proliferation in vivo is presumed to reflect a T cell receptor (TCR)-mediated polyclonal response directed to various environmental antigens. However, the massive proliferation of T cells seen in viral infections is suggestive of a bystander reaction driven by cytokines instead of the TCR. In mice, T cell proli
CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1.: Science. 1996 Jun 28;272(5270):1955-8. Unique Identifier : AIDSLINE MED/96275693; Alkhatib G; Combadiere C; Broder CC; Feng Y; Kennedy PE; Murphy PM; Berger EA; Laboratory of Viral Diseases, National Institute of Allergy and; Infectious Diseases (NIAID), National Institutes of Health (NIH),; Bethesda, Maryland 20892, USA.; Human immunodeficiency virus-type 1 (HIV-1) entry requires fusion cofactors on the CD4+ target cell. Fusin, a heterotrimeric GTP-binding protein (G protein)-coupled receptor, serves as a cofactor for T cell line-tropic isolates. The chemokines RANTES, MIP-1alpha, and MIP-1beta, which suppress infection by macrophage-t
HIV-2 and natural protection against HIV-1 infection [letter; comment]: Science. 1996 Jun 28;272(5270):1959-60. Unique Identifier : AIDSLINE MED/96275694; Greenberg AE; Wiktor SZ; DeCock KM; Smith P; Jaffe HW; Dondero TJ Jr
Modeling HIV concentration during acute AIDS infection [letter; comment]: Science. 1996 Jun 28;272(5270):1960-2. Unique Identifier : AIDSLINE MED/96275695; Wilson SE; Habeshaw JA; Oxford JS
Rate of killing of HIV-infected T cells and disease progression [letter; comment]: Science. 1996 Jun 28;272(5270):1962. Unique Identifier : AIDSLINE MED/96275696; Huynen MA; Neumann AU
AIDS research. Selling the immune system short [news]: Science. 1996 Jul 5;273(5271):30-1. Unique Identifier : AIDSLINE MED/96275578; Cohen J
Origins and working conditions of female sex workers in urban Thailand: consequences of social context for HIV transmission.: Soc Sci Med. 1996 Feb;42(3):453-62. Unique Identifier : AIDSLINE MED/96201047; Wawer MJ; Podhisita C; Kanungsukkasem U; Pramualratana A; McNamara R; Center for Population and Family Health, Columbia University, New; York, NY 10032, USA.; This paper examines the social origins and working conditions of selected female commercial sex workers in Thailand . Quantitative data gathered from 678 commercial sex workers (CSWs) in low-price brothels, tea houses and other work sites in three urban centers were supplemented b
Attitudes of pediatric nurses facing HIV risk.: Soc Sci Med. 1996 Feb;42(3):463-9. Unique Identifier : AIDSLINE MED/96201048; Berkowitz NF; Nuttall RL; Department of Counseling and Developmental Research Methods,; Boston College, Chestnut Hill, MA 02167, USA.; The purpose of this study was to examine health related attitudes, including willingness to provide care, of health care professionals toward HIV-infected patients. To control for attitudes toward people who may have engaged in high risk behaviors for HIV infection, such as intravenous drug use or homosexual behavior,
The influence of laparoscopy on lymphocyte subpopulations in the surgical patient.: Surg Endosc. 1996 May;10(5):481-4. Unique Identifier : AIDSLINE MED/96270202; Vallina VL; Velasco JM; Department of Surgery, Rush University and Rush North Shore; Medical Center, 9600 Gross Point Road, Skokie, IL 60076, USA.; BACKGROUND: Surgical stress is known to disturb the immune system so that the overall picture is one of generalized immunosuppression proportional to the degree of stress. It has been suggested that minimally invasive procedures, i.e., laparoscopic cholecystectomy, should be accompanied by decreased surgical stress. M
Scottish national survey of tuberculosis notifications 1993 with special reference to the prevalence of HIV seropositivity.: Thorax. 1996 Jan;51(1):78-81. Unique Identifier : AIDSLINE MED/96264411; Leitch AG; Rubilar M; Curnow J; Boyd G; Forbes GI; Burns S; Watt B; Royal Victoria Chest Clinic, Chalmers Hospital, Edinburgh, UK.; BACKGROUND: The study sought to determine the contribution of HIV seropositivity to the arrest of decline in tuberculosis notifications in Scotland. METHODS: Survey forms relating to each tuberculosis notification in 1993 were completed by the notifying consultant. Voluntary anonymous HIV testing of tuberculosis cases
[Quality adjusted life years in assessment of preventive measures. Should blood donors be tested for HTLV-I/II infections?]: Tidsskr Nor Laegeforen. 1996 Apr 20;116(10):1229-32. Unique Identifier : AIDSLINE MED/96250228; Magnus P; Stigum H; Nord E; Bjorndal A; Samdal HH; Skulberg A; Heier HE; Seksjon for epidemiologi, Statens helsetilsyn, Oslo.; In planning preventive health measures, quality adjusted life-years (QALYs) are useful as a measure of benefit. As an example, the question of whether blood donors should be routinely tested for antibodies to the Human T-lymphotropic viruses I and II (HTLV I/II) is analysed. A mathematical model was set up to describe
Lead differentially modifies cytokine production in vitro and in vivo.: Toxicol Appl Pharmacol. 1996 May;138(1):149-57. Unique Identifier : AIDSLINE MED/96218956; Heo Y; Parsons PJ; Lawrence DA; Wadsworth Center, New York State Department of Health, Albany; 12201, USA.; An imbalance between helper T cell type 1 (Th1) and helper T cell type 2 (Th2) activation can result in immunodysregulations leading to impaired cell-mediated immunity with an increased incidence of infectious disease or cancer and/or aberrant humoral immunity that may culminate with an autoimmune disease. Mercury, a
Characterization of chemical allergens as a function of divergent cytokine secretion profiles induced in mice.: Toxicol Appl Pharmacol. 1996 Jun;138(2):308-16. Unique Identifier : AIDSLINE MED/96234330; Dearman RJ; Basketter DA; Kimber I; Zeneca Central Toxicology Laboratory, Macclesfield, Cheshire,; United Kingdom.; Allergic contact dermatitis (contact sensitivity) may be caused by a wide variety of chemicals. In addition, some chemical allergens may also induce respiratory sensitization. It has been demonstrated previously that topical exposure of mice to chemical contact and respiratory sensitizers stimulates divergent immune r
Induction and analysis of lethal graft-versus-host disease in tolerant mice.: Transplant Proc. 1996 Jun;28(3):1241-3. Unique Identifier : AIDSLINE MED/96257393; Vegh P; Vizler C; Janossy T; Savelkoul HF; Nyirati I; Benner R; Department of Experimental Surgery, Albert Szent-Gyorgyi Medical; University, Szeged, Hungary.
Early steroid withdrawal after kidney transplantation.: Transplant Proc. 1996 Jun;28(3):1342-5. Unique Identifier : AIDSLINE MED/96257438; Yagisawa T; Toma H; Ota K; Tanabe K; Ishikawa N; Tokumoto N; Yaguchi H; Nakada T; Kidney Center, Tokyo Women's Medical College, Japan.
Evaluation of serum immunological parameters in acute renal allograft rejection.: Transplant Proc. 1996 Jun;28(3):1443-4. Unique Identifier : AIDSLINE MED/96257484; Yang J; Li XW; Zheng FL; Bi ZQ; Department of Internal Medicine, Peking Union Medical College; Hospital, Chinese Academy of Medical Sciences, Beijing, P.R.; China.
Differences in cellular mechanisms in early and late immunological responses after liver transplantation in rats.: Transplant Proc. 1996 Jun;28(3):1782-3. Unique Identifier : AIDSLINE MED/96257633; Yamaguchi J; Ishii T; Kamohara Y; Gu W; Yamamoto T; Mizoe A; Azuma T; Fujioka H; Furui J; Kanematsu T; Department of Surgery II, Nagasaki University School of Medicine,; Japan.
Role of ICAM-1 in chronic rejection in the rat heart transplantation model.: Transplant Proc. 1996 Jun;28(3):1822. Unique Identifier : AIDSLINE MED/96257651; Hamano K; Ito H; Suzuki K; Shirasawa B; Gohra H; Katoh T; Fujimura Y; Tsuboi H; Esato K; Department of Surgery I, Yamaguchi University, School of; Medicine, Japan.
Effect of recipient T cell subset depletion on graft coronary arteriosclerosis induction in the rat retransplant model.: Transplant Proc. 1996 Jun;28(3):1828-9. Unique Identifier : AIDSLINE MED/96257655; Izutani H; Miyagawa S; Shirakura R; Mikata S; Tanemura M; Fukushima N; Nakata S; Matsuda H; First Department of Surgery, Osaka University Medical School,; Japan.
Commercial living-nonrelated renal transplantation: observations on early complications.: Transplant Proc. 1996 Jun;28(3):1941-4. Unique Identifier : AIDSLINE MED/96257707; Hussein MM; Mooij JM; Roujouleh H; el-Sayed H; Department of Nephrology and Haemodialysis, Al Hada Armed Forces; Hospital, Taif, Saudi Arabia.
Expansion of a peripheral blood perforin+ CD8+ T-cell subset in long-term surviving lung transplanted patients.: Transplant Proc. 1996 Jun;28(3):1964-7. Unique Identifier : AIDSLINE MED/96257714; Berthou C; Legros-Maida S; Soulie A; Wargnier A; Guillet J; Lafaurie C; Stern M; Sasportes M; Israel-Biet D; INSERM U 93, Hopital St Louis, Paris, France.
Construction, expression, and immunogenicity of chimeric HIV-1 virus-like particles.: Virology. 1996 Jun 1;220(1):128-40. Unique Identifier : AIDSLINE MED/96240635; Wagner R; Deml L; Schirmbeck R; Niedrig M; Reimann J; Wolf H; Institute of Medical Microbiology, University of Regensburg,; Germany. Ralf.Wagner@kliuik.uniRegensburg.de; The group-specific antigens Pr55gag of human immunodeficiency virus type-1 (HIV-1) self-assemble into noninfectious virus-like particles (VLP) that are released from various eucaryotic cells by budding. Deletion analysis of Pr55gag mutants revealed three domains into which sequences of the third variable domain V3 or
The human immunodeficiency virus type 1 Vpu protein tethered to the CD4 extracellular domain is localized to the plasma membrane and is biologically active in the secretory pathway of mammalian cells: implications for the mechanisms of Vpu function.: Virology. 1996 Jun 1;220(1):141-51. Unique Identifier : AIDSLINE MED/96240636; Raja NU; Jabbar MA; Department of Molecular Biology, Cleveland Clinic Foundation,; Ohio 44195, USA.; The HIV-1 Vpu protein induces the proteolysis of CD4 in the endoplasmic reticulum (ER) and enhances the release of virus particles from the plasma membrane. The two biological activities of HIV-1 Vpu appear to be reconstituted in distinct membrane compartments of the mammalian cell. We carried out experiments to under
Evidence for direct association of Vpr and matrix protein p17 within the HIV-1 virion.: Virology. 1996 Jun 1;220(1):208-12. Unique Identifier : AIDSLINE MED/96240644; Sato A; Yoshimoto J; Isaka Y; Miki S; Suyama A; Adachi A; Hayami M; Fujiwara T; Yoshie O; Shionogi Institute for Medical Science, Osaka, Japan.; Vpr is one of the auxiliary proteins of HIV-1 and is selectively incorporated into the virion by a process involving the C-terminal p6 portion of the Gag precursor Pr55. Vpr and the matrix protein p17 are the components of the viral preintegration complex and appear to play important roles in the nuclear transport of
[The military medical aspects of HIV infection]: Voen Med Zh. 1992 Feb;(2):62-5. Unique Identifier : AIDSLINE MED/96222268; Dmitriev VI; Bel'gesov NV; Pastushenkov VL; Kuzmich AN; Mitin IuA
[Official statistical data]: Voen Med Zh. 1992 Feb;(2):65-6. Unique Identifier : AIDSLINE MED/96222269
[Quantitative determination of the infective activity of the human immunodeficiency virus by plaque formation using monolayer cultures]: Vopr Virusol. 1995 Sep-Oct;40(5):202-5. Unique Identifier : AIDSLINE MED/96109912; Nosik MN; Stepanova LG; Matsevich GR; A method for assessment of the infective activity of HIV using plaque formation method with human diploid cells (strains L-65, L-68, L-72) has been developed. This method is not inferior to plaque formation with poly-L-lysine in sensitivity, but superior to it in reproducibility of results and standardization of the t
[Morphological analysis of a cell system, infected with different strains of the human immunodeficiency virus]: Vopr Virusol. 1995 Sep-Oct;40(5):227-31. Unique Identifier : AIDSLINE MED/96109920; Gushchin BV; Gushchina EA; Nosik DN; Kalnina LB; Korneeva MN; Bochkova MS; Kiseleva IA; Pokrovskii VV; Klimenko SM; Cell systems infected with 63 strains of types 1 and 2 HIV virus (HIV-1 and HIV-2) were examined under electron microscope. HIV virions were most frequently detected near the cell membrane or budding from it. In the cytoplasm HIV occurred only in vacuole-like formations. Accumulations of mature virions were seen in th
[The cytotoxic activity in intestinal lamina propria and peripheral blood in AIDS and Crohn disease]: Z Gastroenterol. 1996 Feb;34(2):111-5. Unique Identifier : AIDSLINE MED/96230708; Fink CO; Raedler A; Voss A; Medizinische Klinik I, Stadtisches Krankenhaus Solingen.; In this study the cytotoxic activity of natural killer cells (NK) and lymphokine activated killer cells (LAK) in the peripheral blood was examined in ten patients with AIDS and in ten patients with Crohn s disease. The results were compared to the values of ten healthy patients. Cells of the lamina propria of the colo
Mycobacterium haemophilum cellulitis and osteomyelitis in a man with AIDS.: J Am Board Fam Pract. 1996 Mar-Apr;9(2):122-4. Unique Identifier : AIDSLINE MED/96236272; Holladay KL; Carmichael JK; University of Arizona College of Medicine, Tucson, USA.
Treatment of AIDS and HIV-related conditions--1996.: J Am Board Fam Pract. 1996 Mar-Apr;9(2):125-48. Unique Identifier : AIDSLINE MED/96236273; Goldschmidt RH; Dong BJ; Family Practice Residency Program, San Francisco General; Hospital, CA 94110, USA.
Chronic active Epstein-Barr virus infection with giant coronary aneurysms.: Am J Clin Pathol. 1996 Jun;105(6):733-6. Unique Identifier : AIDSLINE MED/96247402; Nakagawa A; Ito M; Iwaki T; Yatabe Y; Asai J; Hayashi K; Department of Pathology, Nagoya University Hospital, Japan.; Chronic active Epstein-Barr virus infection (CAEBV) is a nonfamilial syndrome that shows a specific immunodeficiency for the Epstein-Barr virus (EBV). Prolonged fever, hepatosplenomegaly, lymphadenopathy, and liver dysfunction were seen in CAEBV, but cardiac complications are rare. An autopsy case of CAEBV with giant
Transmission of Mycobacterium tuberculosis from tuberculosis patients with HIV infection or AIDS.: Am J Epidemiol. 1996 Jul 1;144(1):69-77. Unique Identifier : AIDSLINE MED/96259465; Cauthen GM; Dooley SW; Onorato IM; Ihle WW; Burr JM; Bigler WJ; Witte J; Castro KG; Division of Tuberculosis Elimination, Centers for Disease Control; and Prevention, Atlanta, GA 30333, USA.; Contacts exposed to tuberculosis patients with acquired immunodeficiency syndrome (AIDS) or human immunodeficiency virus (HIV) infection were compared with contacts of HIV-negative patients for evidence of Mycobacterium tuberculosis transmission, based on a review of records of tuberculin skin tests administered durin
Home HIV test gets nod [news]: Am J Nurs. 1996 Jul;96(7):14. Unique Identifier : AIDSLINE MED/96280040
A new class of anti-HIV drugs debuts.: Am J Nurs. 1996 Jul;96(7):59-63. Unique Identifier : AIDSLINE MED/96280051
Treatment of clinically resistant cytomegalovirus retinitis with combined intravitreal injections of ganciclovir and foscarnet.: Am J Ophthalmol. 1996 Jul;122(1):121-3. Unique Identifier : AIDSLINE MED/96271321; Desatnik HR; Foster RE; Lowder CY; Division of Ophthalmology, Cleveland Clinic Foundation, OH; 44195-5024, USA. Fosterr@cesmtp.ccf.org; PURPOSE: To determine the efficacy of combined ganciclovir and foscarnet intravitreal injections in controlling clinically resistant cytomegalovirus retinitis in a 37-year-old man with the acquired immunodeficiency syndrome who refused systemic therapy. METHODS: The patient refused
Correlation between intraocular pressure and CD4+ T-lymphocyte counts in patients with human immunodeficiency virus with and without cytomegalovirus retinitis.: Am J Ophthalmol. 1996 Jul;122(1):91-6. Unique Identifier : AIDSLINE MED/96271312; Arevalo JF; Munguia D; Faber D; Friedlander SM; Quiceno JI; Rahhal FM; Kirsch LS; Freeman WR; Department of Ophthalmology, University of California, San Diego,; La Jolla 92093-0946, USA.; PURPOSE: To determine the intraocular pressure in patients with human immunodeficiency virus (HIV) with and without cytomegalovirus retinitis, and to correlate intraocular pressure with CD4+ T-lymphocyte count and the presence, extent, and activity of cytomegalovirus retinitis. MET
Family planning, sexually transmitted diseases, and the prevention of AIDS--divided we fail? [editorial]: Am J Public Health. 1996 Jun;86(6):783-4. Unique Identifier : AIDSLINE MED/96258321; Stein Z
A prison release program for HIV-positive women: linking them to health services and community follow-up [letter]: Am J Public Health. 1996 Jun;86(6):886-7. Unique Identifier : AIDSLINE MED/96258344; Flanigan TP; Kim JY; Zierler S; Rich J; Vigilante K; Bury-Maynard D
Interactions of HIV-1 proteins with human T-cell cyclophilin A.: Ann N Y Acad Sci. 1996 May 15;782:456-61. Unique Identifier : AIDSLINE MED/96250162; Hammerschmid F; Billich A; Wasserbauer E; Rosenwirth B; Sandoz Forschunginstitut Wien, Austria.
Tuberculosis makes a comeback.: AORN J. 1996 Apr;63(4):705-7, 709, 713-5. Unique Identifier : AIDSLINE MED/96267665; Haney PE; Raymond BA; Hernandez JM; Seeman S; Berry AJ; South Texas Veterans Health Care System, Audie L. Murphy; Division, San Antonio, USA.; Tuberculosis (TB) has plagued mankind for many centuries. In the past, the number of people affected with this potentially deadly disease declined, but there has been a recent dramatic increase in TB incidence. This increase is attributed largely to people who are coinfected with TB and HIV and to the development of r
Nurses on Presidential Advisory Council on HIV/AIDS [news]: AORN J. 1996 Apr;63(4):778. Unique Identifier : AIDSLINE MED/96294616
The role of Epstein-Barr virus in Hodgkin's disease from different geographical areas.: Arch Dis Child. 1996 Jan;74(1):27-31. Unique Identifier : AIDSLINE MED/96264348; Weinreb M; Day PJ; Niggli F; Powell JE; Raafat F; Hesseling PB; Schneider JW; Hartley PS; Tzortzatou-Stathopoulou F; Khalek ER; Mangoud A; El-Safy UR; Madanat F; Al Sheyyab M; Mpofu C; Revesz T; Rafii R; Tiedemann K; Waters KD; Barrantes JC; Nyongo A; Riyat MS; Mann JR; Children's Hospital, Ladywood Middleway, Birmingham, UK.; Recent studies have suggested that Epstein-Barr virus (EBV) may play a role in the aetiology of Hodgkin s disease. To determine the role of EBV in childhood Hodgkin s disease in different geographical areas, immunohistochemical staining and in situ hybridisation were used to analyse latent membrane protein 1 (LMP 1) a
Thalidomide treatment of mucosal ulcerations in HIV infection.: Arch Dis Child. 1996 Jan;74(1):64-5. Unique Identifier : AIDSLINE MED/96264359; Soler RA; Migliorati C; van Waes H; Nadal D; Infectious Diseases Unit, University Children's Hospital of; Zurich, Switzerland.; Pain relief and resolution of oral and perianal ulceration after treatment with thalidomide in a 14 year old girl with vertically acquired HIV infection is reported.
Transmission of tuberculosis to contacts of sputum positive adults in Malawi.: Arch Dis Child. 1996 Feb;74(2):140-3. Unique Identifier : AIDSLINE MED/96264255; Topley JM; Maher D; Mbewe LN; College of Medicine, University of Malawi, Blantyre.; Over a period of one year from June 1993 to May 1994, 282 children under 6 years old who were household contacts of sputum positive adults with tuberculosis were evaluated in a screening clinic. Of these, 180 (63.8%) had evidence of tuberculosis, a much higher transmission rate than reported elsewhere. HIV seropositiv
Assessment of cytomegalovirus retinitis. Clinical evaluation vs centralized grading of fundus photographs. Studies of Ocular Complications of AIDS Research Group, AIDS Clinical Trials Group.: Arch Ophthalmol. 1996 Jul;114(7):791-805. Unique Identifier : AIDSLINE MED/96269310; BACKGROUND: In the Foscarnet-Ganciclovir Cytomegalovirus ( CMV ) Retinitis Trial, time to first progression of newly diagnosed CMV retinitis was similar in the 2 treatment groups but was shorter when assessed by grading of fundus photographs at a central reading c
Special issue: AIDS and the eye.: Arch Ophthalmol. 1996 Jul;114(7):791-892. Unique Identifier : AIDSLINE MED/96293345
Cytomegalovirus retinitis and viral resistance. Prevalence of resistance at diagnosis, 1994. Cytomegalovirus Retinitis and Viral Resistance Study Group.: Arch Ophthalmol. 1996 Jul;114(7):809-14. Unique Identifier : AIDSLINE MED/96269311; Jabs DA; Dunn JP; Enger C; Forman M; Bressler N; Charache P; Department of Ophthalmology, Johns Hopkins University School of; Medicine, Baltimore, Md., USA.; OBJECTIVE: To determine the prevalence of cytomegalovirus ( CMV ) isolates resistant to ganciclovir sodium or foscarnet sodium at the time of diagnosis of CMV retinitis, prior to the initiation of therapy. DESIGN: Prospective e
Use of the ganciclovir implant in the treatment of recurrent cytomegalovirus retinitis.: Arch Ophthalmol. 1996 Jul;114(7):815-20. Unique Identifier : AIDSLINE MED/96269312; Marx JL; Kapusta MA; Patel SS; LaBree LD; Walonker F; Rao NA; Chong LP; Doheny Eye Institute, Department of Ophthalmology, University of; Southern California School of Medicine, Los Angeles, USA.; OBJECTIVE: To evaluate the efficacy of the ganciclovir implant in the treatment of recurrent cytomegalovirus ( CMV ) retinitis. METHODS: Patients with acquired immunodeficiency syndrome and recurrent CMV retinitis were evaluate
Occurrence of cytomegalovirus retinitis after human immunodeficiency virus immunosuppression.: Arch Ophthalmol. 1996 Jul;114(7):821-7. Unique Identifier : AIDSLINE MED/96269313; Hoover DR; Peng Y; Saah A; Semba R; Detels RR; Rinaldo CR Jr; Phair JP; Department of Epidemiology, School of Public Health, Johns; Hopkins University, Baltimore, Md., USA.; OBJECTIVE: To estimate the incidence and prevalence of cytomegalovirus retinitis (CMV-R) in late-stage human immunodeficiency virus type 1 disease. DESIGN: Cohort study. SETTING: The Multicenter AIDS Cohort Study, an ongoing 10-year study of human immunodeficiency virus type 1-infe
Effectiveness of entoptic perimetry for locating peripheral scotomas caused by cytomegalovirus retinitis.: Arch Ophthalmol. 1996 Jul;114(7):828-31. Unique Identifier : AIDSLINE MED/96269314; Plummer DJ; Arevalo JF; Fram N; Quiceno JI; Sample PA; Freeman WR; Shiley Eye Center, Department of Ophthalmology, University of; California, San Diego School of Medicine, La Jolla, USA.; OBJECTIVE: To determine the the effectiveness of random particle motion, presented on a computer monitor, as a noninvasive test for detecting cytomegalovirus retinitis. DESIGN: A prospective masked study in which patients were asked to trace out any disturbances on a transparency p
Acquired immunodeficiency syndrome--associated herpes simplex virus retinitis. Clinical description and use of a polymerase chain reaction--based assay as a diagnostic tool.: Arch Ophthalmol. 1996 Jul;114(7):834-40. Unique Identifier : AIDSLINE MED/96269315; Cunningham ET Jr; Short GA; Irvine AR; Duker JS; Margolis TP; Francis I. Proctor Foundation, School of Medicine, University of; California-San Francisco, USA.; OBJECTIVES: To describe 2 patients with acquired immunodeficiency syndrome who experienced a rapidly progressive, bilateral retinitis due to herpes simplex virus (HSV) (1 case due to HSV type 1 [HSV-1] and 1 case due to HSV type 2 [HSV-2] and to present a novel diagnostic polymerase chain reaction (PCR)-based assay. M
Measuring visual function and quality of life in patients with cytomegalovirus retinitis. Development of a questionnaire. Studies of Ocular Complication of AIDS Research Group.: Arch Ophthalmol. 1996 Jul;114(7):841-7. Unique Identifier : AIDSLINE MED/96269316; Wu AW; Coleson LC; Holbrook J; Jabs DA; Department of Health Policy and Management, School of Hygiene and; Public Health, Johns Hopkins University, Baltimore, Md., USA.; OBJECTIVE: To develop and test a brief questionnaire designed to assess visual symptoms, visual function in daily activities, and impact of treatment administration in patients with cytomegalovirus retinitis related to acquired immunodeficiency syndrome. DESIGN: Observational cross
Clinical vs photographic assessment of treatment of cytomegalovirus retinitis. Foscarnet-Ganciclovir Cytomegalovirus Retinitis Trial Report 8. Studies of Ocular Complications of AIDS Research Group, AIDS Clinical Trials Group.: Arch Ophthalmol. 1996 Jul;114(7):848-55. Unique Identifier : AIDSLINE MED/96269317; OBJECTIVE: To illustrate 2 common problems encountered in evaluating the response of cytomegalovirus retinitis to antiviral treatment and to consider their clinical importance. METHODS: Four illustrative cases were selected from 76 cases reviewed during a study that compared clinic
General principles for AIDS research [editorial]: Arch Ophthalmol. 1996 Jul;114(7):862. Unique Identifier : AIDSLINE MED/96269319; Kupfer C
Acquired immunodeficiency syndrome and the eye--1996 [editorial]: Arch Ophthalmol. 1996 Jul;114(7):863-6. Unique Identifier : AIDSLINE MED/96269320; Jabs DA
Cytomegalovirus keratitis in acquired immunodeficiency syndrome [clinical conference]: Arch Ophthalmol. 1996 Jul;114(7):869-72. Unique Identifier : AIDSLINE MED/96269322; Wilhelmus KR; Font RL; Lehmann RP; Cernoch PL; Department of Ophthalmology Cullen Eye Institute, Baylor College; of Medicine, Houston, Tex., USA.; A man with acquired immunodeficiency syndrome developed a generalized rash and bilateral dendritic epithelial keratitis without retinitis. Cytologic examination of superficial corneal scrapings showed many megalosyncytial giant cells that were highly characteristic of cytomegalovirus
Bilateral endogenous Fusarium endophthalmitis associated with acquired immunodeficiency syndrome [clinical conference]: Arch Ophthalmol. 1996 Jul;114(7):873-7. Unique Identifier : AIDSLINE MED/96269323; Glasgow BJ; Engstrom RE Jr; Holland GN; Kreiger AE; Wool MG; Department of Pathology, Jules Stein Eye Institute, Los Angeles,; CA 90095-7000, USA.; A 51-year-old man with acquired immunodeficiency syndrome and cytomegalovirus retinitis had bilateral endogenous fungal endophthalmitis. Cultures yielded Fusarium species. Histopathologic examination showed a severe necrotizing acute and granulomatous reaction, with numerous fungal
Anterior-segment ultrasound biomicroscopy in a patient with AIDS and bilateral angle-closure glaucoma secondary to uveal effusions [letter]: Arch Ophthalmol. 1996 Jul;114(7):878-9. Unique Identifier : AIDSLINE MED/96269324; Krzystolik MG; Kuperwasser M; Low RM; Dreyer EB
Endogenous bacterial endophthalmitis as a complication of intravenous therapy for cytomegalovirus retinopathy [letter]: Arch Ophthalmol. 1996 Jul;114(7):879-80. Unique Identifier : AIDSLINE MED/96269325; Tufail A; Weisz JM; Holland GN
Metastatic choroidal abscess in the acquired immunodeficiency syndrome [letter]: Arch Ophthalmol. 1996 Jul;114(7):880-1. Unique Identifier : AIDSLINE MED/96269326; Walton RC; Wilson J; Chan CC
Long-term, successful maintenance of bilateral cytomegalovirus retinitis using exclusively local therapy [letter]: Arch Ophthalmol. 1996 Jul;114(7):881-2. Unique Identifier : AIDSLINE MED/96269327; Duker JS; Ashton P; Davis JL; Keller R; Chuang E
Cataract extraction after silicone oil repair of retinal detachments due to necrotizing retinitis.: Arch Ophthalmol. 1996 Jul;114(7):885-92. Unique Identifier : AIDSLINE MED/96269328; Meldrum ML; Aaberg TM; Patel A; Davis J; Bascom Palmer Eye Institute, University of Miami, Fla, USA.; Cataract is common after silicone oil repair of retinal detachment due to necrotizing retinitis in acquired immunodeficiency syndrome. Surgical management has not been reported. Twenty-two eyes of 19 patients were reviewed. The majority underwent phacoemulsification with a posterior chamber convexoplano implant withou
Serous retinal detachments in a patient with clinically resistant cytomegalovirus retinitis.: Arch Ophthalmol. 1996 Jul;114(7):896-7. Unique Identifier : AIDSLINE MED/96269329; Dodds EM; Lowder CY; Foster RE; Avery RK; Prayson RA; Division of Ophthalmology, Cleveland Clinic Foundation, OH 44195,; USA.
Increased prevalence of HIV-related retinal microangiopathy syndrome in patients with hepatitis C [letter]: Arch Ophthalmol. 1996 Jul;114(7):899. Unique Identifier : AIDSLINE MED/96269330; Thierfelder S; Linnert D; Grehn F
An upstream positive regulatory element in human GM-CSF promoter is recognized by NF-kappa B/Rel family members.: Biochem Biophys Res Commun. 1996 Jun 5;223(1):64-72. Unique Identifier : AIDSLINE MED/96254030; Musso M; Ghiorzo P; Fiorentini P; Giuffrida R; Ciotti P; Garre C; Ravazzolo R; Bianchi-Scarra G; IBiG, Institute of Biology and Genetics, University of Genova,; Italy.; To further extend the previous analysis of cis-acting elements and cognate trans-acting factors that contribute to GM-CSF transcriptional regulations, we have examined a promoter region between -1742 and -2010. DNase I footprinting assays showed four protected sequences named A, B, C and D. DNA transfections in the T-
Pyrazole-related nucleosides. 4. Synthesis and antitumor activity of some 1-tetrahydropyranyl-4-substituted pyrazoles.: Anticancer Drug Des. 1996 Apr;11(3):193-204. Unique Identifier : AIDSLINE MED/96270763; Manfredini S; Bazzanini R; Baraldi PG; Bonora M; Marangoni M; Simoni D; Pani A; Scintu F; Pinna E; Pisano L; La Colla P; Dipartimento di Scienze Farmaceutiche, Universita di Ferrara,; Italy.; Continuing our studies on the structure-activity relationships of some pyrazole nucleosides (1a-h) structurally related to ribavirin, tiazofurin and selenazofurin, we describe here the synthesis and antitumor/antiviral/antimicrobial activity of a new series of 1-tetrahydropyranyl-4-substituted pyrazoles. In this study
Cytomegalovirus sinusitis. A new manifestation of AIDS.: Arch Otolaryngol Head Neck Surg. 1996 Jul;122(7):789-91. Unique Identifier : AIDSLINE MED/96280081; Marks SC; Upadhyay S; Crane L; Department of Otolaryngology-Head and Neck Surgery, Wayne State; University School of Medicine, Detroit, Mich, USA.; Cytomegalovirus is a common pathogen in patients infected with the human immunodeficiency virus. In this article, cytomegalovirus sinusitis is described and documented for the first time, to our knowledge. Cytomegalovirus was cultured from the sinuses of four patients who were posi
[Germicidal activity of the detergent VIRKON]: Ann Ig. 1995 Jan-Feb;7(1):35-41. Unique Identifier : AIDSLINE MED/96274914; Braga A; Primario Lab. di Microbiologia, Ospedale di Legnano.
[Evaluation of the antiviral activity of the disinfectant VIRKON]: Ann Ig. 1995 Jan-Feb;7(1):55-62. Unique Identifier : AIDSLINE MED/96274917; Bonfanti C; Pollara P; De Rango C; Turano A; Istituto di Microbiologia, Universita degli Studi di Brescia.
[Pancreatic disease in patients with HIV treated with didanosine (DDI)]: Rev Esp Enferm Dig. 1996 Feb;88(2):114-7. Unique Identifier : AIDSLINE MED/96267356; Ortega Gonzalez E; Martin Herrera A; Lopez de Medrano V; de Lelis FP; Ronda Gasulla FA; Gil Egea M; Ballester Belda E; Herrera Ballester A; Seccion de Enfermedades Infecciosas, Hospital General; Universitario, Valencia.; Pancreatic involvement has been studied in 70 HIV infected patients, in diverse stages, that were treated with didanosine (ddI), both as monotherapy or associated to zidovudine; 38% of patients presented adverse reaction that obliged to withdraw the medication: pancreatitis (4%), hyperamylasemia (21%) and abdominal pa
[Idiopathic esophageal ulcer with fistulization to the bronchial tree in a HIV-positive patient]: Rev Esp Enferm Dig. 1996 Feb;88(2):133-6. Unique Identifier : AIDSLINE MED/96267359; Garcia Duran F; Banos E; Hernandez-Albujar A; Perez de Ayala V; Jimenez P; Menchen P; Cos E; Senent C; Servicio de Aparato Digestivo, Hospital General Gregorio; Maranon, Madrid.; Idiopathic esophageal ulcerations (IEUs) associated with human immunodeficiency virus (HIV) infection are now recognized as an important cause of esophageal disease in this population. We report one case of IEU complicated with a fistula to the bronchial tree. Given his variable appearance, which may mimic other cause
[Acute pancreatitis and acquired immunodeficiency syndrome]: Rev Esp Enferm Dig. 1996 Feb;88(2):155-9. Unique Identifier : AIDSLINE MED/96267364; Talens A; Montoya E; Cubells ML; Garcia Novales J; Martinez Sanjuan V; Hernandez E; Pedro F; Donderis P; Celma J; Servicio de Radiodiagnostico, Hospital General Universitario,; Valencia.; Viral acute pancreatitis in Human Immunodeficiency Virus (HIV) infected patients has been occasionally described. We studied nine patients with HIV antibodies and acute pancreatitis attributed to Cytomegalovirus and/or Cryptosporidium infection. In four patients the clinical picture was consistent with acute pancreati
Attitudes of dental health care workers to HIV infected persons [letter]: Br Dent J. 1996 May 11;180(9):326. Unique Identifier : AIDSLINE MED/96248840; Porter S; Scully C
Patterns of sexual behavior and risk taking among young New York City gay men.: AIDS Educ Prev. 1995;7(5 Suppl):13-23. Unique Identifier : AIDSLINE MED/96113086; Meyer IH; Dean L; AIDS Research Unit, Columbia University, School of Public Health,; New York, NY 10032, USA.; One-hundred and seventy-four young New York City gay men (aged 18-24) were studied over a two-year period. We describe patterns of HIV risk taking behavior and factors that predict risk taking. Among men who engaged in receptive anal intercourse we discerned different patterns of behaviors. We defined risk takers as m
Social and sexual networks: their role in the spread of HIV/AIDS among young gay men.: AIDS Educ Prev. 1995;7(5 Suppl):24-35. Unique Identifier : AIDSLINE MED/96113087; Morris M; Zavisca J; Dean L; Department of Sociology, Columbia University, New York, NY 10027,; USA.; This article examines how networks of social and sexual relations affect risky sexual behavior and HIV seroprevalence among young gay men. Social networks can transmit information and cultural norms regarding safer sex, while networks of sexual partners channel the risk of exposure to HIV infection. These two network
Trends in the AIDS epidemic among men who reported sex with men in New York City: 1981-1993.: AIDS Educ Prev. 1995;7(5 Suppl):3-12. Unique Identifier : AIDSLINE MED/96113085; Fordyce EJ; Williams RD; Surick IW; Shum RT; Quintyne RA; Thomas PA; Office of AIDS Surveillance, New York City Department of Health,; NY 10013, USA.; New York City is a major urban epicenter of the AIDS epidemic in the United States , and has reported nearly one fifth of the nation s cases. This paper chronicles trends in the AIDS epidemic among men who have sex with men (MSM) from 1981 through 1993 in New York City. Annual AIDS inci
Effects of AIDS-related bereavement on HIV progression among New York City gay men.: AIDS Educ Prev. 1995;7(5 Suppl):36-47. Unique Identifier : AIDSLINE MED/96113088; Kemeny ME; Dean L; Department of Psychiatry & Biobehavioral Sciences, University of; California, Los Angeles 90024, USA.; This study investigates the relationship between early AIDS-related bereavement and subsequent changes in CD4 T-cell levels and health over a three- to four-year follow-up period in 85 HIV positive gay men. In addition, two psychological responses to loss, grief, and depression were distinguished and used as predictor
Assisting gay men to maintain safer sex: an evaluation of an AIDS service organization's safer sex maintenance program.: AIDS Educ Prev. 1995;7(5 Suppl):48-63. Unique Identifier : AIDSLINE MED/96113089; Miller RL; Gay Men's Health Crisis, Inc., New York, NY 10011, USA.; As the second decade of the AIDS crisis unfolds, increasing concern has been raised that the widespread adoption of condom use that occurred among gay men in the 1980s is not being maintained. Most interventions to promote condom use among gay men are delivered by community-based organizations via programs that are vi
GMHC volunteers and the challenges and hopes for the second decade of AIDS.: AIDS Educ Prev. 1995;7(5 Suppl):64-79. Unique Identifier : AIDSLINE MED/96113090; Ouellette SC; Cassel JB; Maslanka H; Wong LM; Graduate School and University Center, CUNY, New York 10036, USA.; A documentation of the impact of AIDS on New York City during the first decade of the epidemic must highlight the extraordinary responses of the Gay Men s Health Crisis (GMHC) and other community-based organizations. Data collected from volunteers (n = 587) at the close of this decade are presented to address concerns
A typology of AIDS volunteers.: AIDS Educ Prev. 1995;7(5 Suppl):80-90. Unique Identifier : AIDSLINE MED/96113091; Cassel JB; Ouellette S; GMHC Department of Evaluation Research, New York, NY 10011, USA.; Based on our research of volunteers at Gay Men s Health Crisis (GMHC) in New York City, we developed a typology of AIDS volunteers derived from their responses to our Reasons for Volunteering scale. The scale included six basic reasons, three of which were AIDS-specific and three of which represented more general reas
AIDS service organizations and the gay community.: AIDS Educ Prev. 1995;7(5 Suppl):91-5. Unique Identifier : AIDSLINE MED/96113092; Andriote JM
HIV prevention efforts impaired in New York City.: AIDS Educ Prev. 1995;7(5 Suppl):96-100. Unique Identifier : AIDSLINE MED/96113093; Isbell MT; Gay Men's Health Center, New York, NY 10010, USA.
Kinetic analysis of pausing and fidelity of human immunodeficiency virus type 1 reverse transcription.: Biochemistry. 1996 Apr 16;35(15):5054-62. Unique Identifier : AIDSLINE MED/96267099; Pop MP; Biebricher CK; Max-Planck-Institute for Biophysical Chemistry, Am Fassberg,; Gottingen, Germany.; Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase catalyzes DNA synthesis from RNA and DNA templates by a sequential mechanism. This enzyme is neither processive nor distributive but has a rather intermediate behavior; at any template position, there is a certain probability that the replica strand wil
A kissing complex together with a stable dimer is involved in the HIV-1Lai RNA dimerization process in vitro.: Biochemistry. 1996 Apr 16;35(15):5075-82. Unique Identifier : AIDSLINE MED/96267101; Muriaux D; Fosse P; Paoletti J; Laboratoire de Pharmacologie et Physicochimie des Macromolcules; Biologiques, URA 147 CNRS, Institut Gustave Roussy, Villejuif,; France.; Retroviruses contain a dimeric RNA consisting of two identical molecules of genomic RNA. The interaction between the two monomers is thought to occur near their 5 ends. We previously identified a region upstream from the splice donor site, comprising an autocomplementary sequence, responsible for the formation of dime
Suicide and AIDS: lessons from a case note audit in London.: AIDS Care. 1995;7 Suppl 2:S109-16. Unique Identifier : AIDSLINE MED/96263749; Sherr L; Department of Primary Care and Population Sciences, Royal Free; Hospital School of Medicine, London, UK.; There is growing evidence that HIV infection and AIDS have an impact on a range of suicidal issues. The literature lacks clarity and the subject is traditionally problematic to research. True prevalence is often difficult to gauge and many researchers focus simply on death by suicide rather than exploring the extreme
Suicidal behaviour and HIV infection--is there a link?: AIDS Care. 1995;7 Suppl 2:S117-21. Unique Identifier : AIDSLINE MED/96263750; Catalan J; Pugh K; Charing Cross and Westminster Medical School, Psychological; Medicine Unit, South Kensington, UK.; The association between suicidal behaviour and HIV infection has been the subject of much attention in recent years. In this paper we review the evidence about the prevalence of suicide, suicidal ideation and deliberate self-harm in individuals with HIV infection. Finally we discuss the significance of the findings, i
Epidemiology of suicide among persons with AIDS.: AIDS Care. 1995;7 Suppl 2:S123-8. Unique Identifier : AIDSLINE MED/96263751; Starace F; Department of Psychology, University of Napoli, Italy.; In spite of the attention devoted by researchers and clinicians to the suicidal risk of AIDS patients, the magnitude of the phenomenon has not yet been clarified. Indeed, some authors have found a rate of suicide among subjects with AIDS 66 times higher than that of the general population (Marzuk et al., 1988a), where
HIV and suicide in Hamburg.: AIDS Care. 1995;7 Suppl 2:S129-34. Unique Identifier : AIDSLINE MED/96263752; Pueschel K; Heinemann A; Institute of Forensic Medicine, University of Hamburg, Germany.; Established data relating to HIV infection, AIDS, drug user related deaths and suicides were evaluated at the Institute of Forensic Medicine in Hamburg in order to gain an insight into suicide and HIV. There was no evidence of an increased suicide ratio among HIV infected drug users. The drug aid system appears to be
AIDS and suicide issues in Spain.: AIDS Care. 1995;7 Suppl 2:S135-8. Unique Identifier : AIDSLINE MED/96263753; Carvajal MJ; Vicioso C; Santamaria JM; Bosco A; Psychiatry Unit, Hospital Civil de Basurto, Bilbao, Spain.; Current suicidality and other characteristics were assessed in 442 HIV-infected patients, independent of clinical stage, who had been referred to the Consultation Liaison Psychiatrist from an Infectious Disease Unit of a General Hospital in Spain . The referrals were made over a peri
Suicide and custody.: AIDS Care. 1995;7 Suppl 2:S139-43. Unique Identifier : AIDSLINE MED/96263754; Casale S; National AIDS and Prison Forum, NACRO, London, UK.; Custodial settings are recognized as an important context both with respect to suicide and self-harm and for HIV prevention and care. This article examines briefly what is known about suicide and self harm in relation to custody, emphasizing the increased risk of suicide and self-harm with suicidal intent among certai
Drug misuse and suicide: assessing the impact of HIV.: AIDS Care. 1995;7 Suppl 2:S145-55. Unique Identifier : AIDSLINE MED/96263755; Klee H; Social Research on Health and Substance Abuse, Manchester; Metropolitan University, Elizabeth Gaskell Campus, Manchester,; UK.; The mortality rate among drug users is higher than that of the general population. There is some evidence that the risk of suicide is also higher, although major methodological difficulties tend to cast doubt on their accuracy. The factors generally known to be associated with suicide such as mental and physical healt
The risk of suicide in people with haemophilia who are HIV infected.: AIDS Care. 1995;7 Suppl 2:S157-61. Unique Identifier : AIDSLINE MED/96263756; Jones P; Haemophilia Centre, Royal Victoria Infirmary, Newcastle upon; Tyne, UK.; The incidence of suicide in the HIV infected haemophilic population of the United Kingdom is low. Between 1985, when most patients were tested for HIV infection, and 1993 3 possibly HIV-related suicides were reported to Haemophilia Centre Directors. It is argued that haemophilia compre
Euthanasia, assisted suicide and AIDS.: AIDS Care. 1995;7 Suppl 2:S163-7. Unique Identifier : AIDSLINE MED/96263757; Laane HM; Amsterdam, Netherlands.; Euthanasia is the termination of the life of a patient by a doctor at the request of the patient. Over the past 15 years AIDS has become the most common cause of death among men aged 20-50 years in Amsterdam. It follows from this that in Amsterdam euthanasia and assisted suicide among PWAs is seen relatively frequentl
AIDS and euthanasia.: AIDS Care. 1995;7 Suppl 2:S169-73. Unique Identifier : AIDSLINE MED/96263758; Green G; Department of Sociology, University of Essex, Colchester, UK.; This paper estimates the proportion of people with HIV who have considered asking assistance to end their lives and explores their motivations and plans of action to hasten death. 16/57 (28%) people with HIV have considered asking for assistance to hasten death, significantly more than seronegative controls (4/67) (3%
AIDS, euthanasia and grief.: AIDS Care. 1995;7 Suppl 2:5175-85. Unique Identifier : AIDSLINE MED/96263759; van den Boom F; Blood Transfusion Council of the Netherlands Red Cross.; Almost 50% of people with AIDS in the Netherlands make the necessary arrangements for a possible death by the administration of thanatic drugs. In approximately 50% of those who arranged for it, euthanasia is performed. Euthanasia is a well-considered decision. By means of eut
Fear of AIDS and suicide in Finland: a review.: AIDS Care. 1995;7 Suppl 2:5187-97. Unique Identifier : AIDSLINE MED/96263760; Aro AR; Henriksson M; Leinikki P; Lonnqvist J; Department of Mental Health, National Public Health Institute,; Helsinki, Finland.; This review presents data on HIV epidemiology and suicide mortality, and summarizes studies on fear of AIDS in completed suicides in Finland . Finland has a low prevalence of HIV and a high suicide mortality. A 12-month nationwide su
Suicide and AIDS: problem identification during counselling.: AIDS Care. 1995;7 Suppl 2:5199-205. Unique Identifier : AIDSLINE MED/96263761; Miller R; Royal Free Hospital, London, UK.; HIV infection brings with it some pertinent aspects that might make those infected, and even those affected, vulnerable to suicidal thoughts or actions. Health care workers, from varied professional backgrounds, are well placed to take a lead in addressing suicidal issues more routinely in the course of counselling. T
Risk of HIV infection in psychiatrically ill patients.: AIDS Care. 1996 Feb;8(1):103-16. Unique Identifier : AIDSLINE MED/96268876; Grassi L; Department of Psychiatry, University of Ferrara, Italy.; The growing spread of HIV infection and AIDS incidence has led the medical milieu to increase efforts in the study of the at-risk population and in the development of prevention programmes. Nevertheless, little attention has been focused on psychiatric patients as a vulnerable and disadvantaged segment of the populati
Responding to the AIDS epidemic in Asia and the Pacific: report on the Third International Conference on AIDS in Asia and the Pacific, Chiang Mai, Thailand, 17-21 September, 1995.: AIDS Care. 1996 Feb;8(1):117-24. Unique Identifier : AIDSLINE MED/96268877; Ford NJ; Institute of Population Studies, University of Exeter, UK.
WHO Global AIDS Statistics.: AIDS Care. 1996 Feb;8(1):127-8. Unique Identifier : AIDSLINE MED/96268878
Coping and social support as determinants of quality of life in HIV/AIDS.: AIDS Care. 1996 Feb;8(1):15-31. Unique Identifier : AIDSLINE MED/96268869; Friedland J; Renwick R; McColl M; Faculty of Medicine, University of Toronto, Ontario, Canada.; Coping, social support and quality of life (QOL) were examined in 120 HIV+ people (mean age = 37). The sample came from ambulatory clinics and drop-in centres in Toronto: 29% had AIDS, 35% were HIV symptomatic, and 35% were asymptomatic. Information was gathered from self-administered questionnaires. Respondents had g
Characteristics of pregnant HIV-1 infected women in Europe. European Collaborative Study.: AIDS Care. 1996 Feb;8(1):33-42. Unique Identifier : AIDSLINE MED/96268870; Thorne C; Newell ML; Dunn D; Peckham C; Epidemiology and Biostatistics Unit, Institute of Child Health,; London, UK.; There is a growing number of infected women in Europe and an increasing proportion of these have acquired their infection through heterosexual contact. Most infected women are of childbearing age and thus increasing numbers of children are at risk of acquiring infection. In this paper we examine the socio-demographic
Trends in heterosexual tertiary students' knowledge of HIV and intentions to avoid people who might have HIV.: AIDS Care. 1996 Feb;8(1):43-53. Unique Identifier : AIDSLINE MED/96268871; Van de Ven P; Turtle A; Kippax S; Crawford J; French J; National Centre in HIV Social Research, School of Behavioural; Sciences, Macquarie University, Sydney, Australia.; This study investigated trends in HIV knowledge and endorsement of social avoidance of people who might be infected with HIV. The respondents (n = 7387) were self-identified heterosexual students. Most of them (n = 6500) were first-year behavioural or biological sciences students from annual surveys (1988-1995) at Mac
The stressors and stress of being HIV-positive.: AIDS Care. 1996 Feb;8(1):5-14. Unique Identifier : AIDSLINE MED/96268868; Thompson SC; Nanni C; Levine A; Pomona College, Claremont, CA 91711, USA.; Questionnaires were administered to 105 HIV-positive men to assess their stressful life events, rated stress, unhealthy behaviours, and psychological adjustment. Two hypotheses about the effects of stressors and stress were tested. It was found that HIV-positive men experience high numbers of stressors and elevated le
AIDS prevention training for pharmacy workers in Mexico City.: AIDS Care. 1996 Feb;8(1):55-69. Unique Identifier : AIDSLINE MED/96268872; Pick S; Reyes J; Alvarez M; Cohen S; Craige J; Troya A; Mexican Family and Population Research Institute (IMIFAP) Mexico; City, Mexico.; Mexican pharmacies play an important adjunct health care role in sexually transmitted disease prevention and treatment. In light of the rapid spread of the AIDS pandemic, research was initiated in 1989 to investigate the feasibility of pharmacies assisting in AIDS and STD prevention and control through community educa
Regional training in AIDS prevention for health and behavioural science leaders in north-eastern Brazil.: AIDS Care. 1996 Feb;8(1):71-84. Unique Identifier : AIDSLINE MED/96268873; Sipan CL; Hovell MF; Blumberg EJ; Hinrichsen SL; Dubeux CR; Center for Behavioral Epidemiology, Graduate School of Public; Health, San Diego State University, La Mesa, California 92182,; USA.; This article reports results of a World AIDS Foundation-funded training programme in North-Eastern Brazil . Training objectives were: (1) to increase the effectiveness of existing medical and behavioural HIV-related services; (2) to prepare professionals to implement and evaluate so
Risk practices for HIV infection and other STDs amongst female prostitutes working in legalized brothels.: AIDS Care. 1996 Feb;8(1):85-94. Unique Identifier : AIDSLINE MED/96268874; Pyett PM; Haste BR; Snow J; Centre for the Study of Sexually Transmissible Diseases, La Trobe; University, Carlton, Victoria, Australia.; Most research investigating risk practices for HIV infection and other STDs amongst sex workers has focused on street prostitutes to the exclusion of those prostitutes who work in different sections of the industry. This is largely a consequence of methodological difficulties in accessing prostitutes other than those
Home medication injection among Latina women in Los Angeles: implications for health education and prevention.: AIDS Care. 1996 Feb;8(1):95-102. Unique Identifier : AIDSLINE MED/96268875; Flaskerud JH; Nyamathi AM; UCLA School of Nursing 90095-1702, USA.; Reuse of needles and syringes after home injection of medications and vitamins may be a risk for transmission of HIV. An exploratory study was done to determine (1) how commonly injectable medications were used in the home; (2) whether needles and syringes were reused; and (3) common practices for cleaning needles and
Intracellular immunization against HIV-1 infection of human T lymphocytes: utility of anti-rev single-chain variable fragments.: Hum Gene Ther. 1995 Dec;6(12):1561-73. Unique Identifier : AIDSLINE MED/96249460; Duan L; Zhu M; Bagasra O; Pomerantz RJ; Department of Medicine, Jefferson Medical College, Thomas; Jefferson University, Philadelphia, PA 19107, USA.; Genetic therapy offers a potentially promising approach with which to combat human immunodeficiency virus type 1 (HIV-1) infections. Several modalities, using protein- and RNA-based systems, have recently been shown to inhibit HIV-1 replication. A single-chain variable fragment (SFv), constructed from the cDNA of a mo
[Clinical situation, knowledge and risky behavior of patients with human immunodeficiency virus infection attending a health center]: Aten Primaria. 1996 Feb 29;17(3):207-10. Unique Identifier : AIDSLINE MED/96274390; Aguado Taberne C; Martinez de la Iglesia J; Espejo Espejo J; Yun Casalilla A; Munoz Alamo M; Ruiz Moral R; Centro de Salud Occidente, Unidad Docente de Medicina de Familia; y Comunitaria.; OBJECTIVE: To establish what information patients diagnosed in our health centre as infected by HIV have about their infection, to evaluate possible changes in their hazardous behaviour and to establish the monitoring level and stage of the condition. DESIGN: An observational study of a crossover nature. Demographic d
Phenotype and frequency of cells secreting IL-2, IL-4, IL-6, IL-10, IFN and TNF-alpha in human peripheral blood.: Cytokine. 1995 Nov;7(8):815-22. Unique Identifier : AIDSLINE MED/96235582; Hagiwara E; Abbasi F; Mor G; Ishigatsubo Y; Klinman DM; Section of Retroviral Immunology, Food and Drug Administration,; Bethesda, MD 20892-4555, USA.; The phenotype and frequency of cells in normal human peripheral blood spontaneously secreting IL-2 , IL-4, IL-6, IL-10, IFN and TNF-alpha ex vivo was determined using ELIspot assays. CD4+ T cells were the dominant source of IL-2 and IL-4 while multiple cell types (prima
HIV in plasma is best predictor of progression to AIDS [news]: BMJ. 1996 Jun 8;312(7044):1437-8. Unique Identifier : AIDSLINE MED/96257085; Roberts J
Survey of HIV patients' views on confidentiality and non-discrimination policies in general practice.: BMJ. 1996 Jun 8;312(7044):1463-4. Unique Identifier : AIDSLINE MED/96257100; Shaw M; Tomlinson D; Higginson I; Department of genitourinary medicine, St Mary's NHS Hospital; Trust, London.
Using condoms to prevent transmission of HIV. Abstinence and fidelity are only fully effective means of prevention [letter]: BMJ. 1996 Jun 8;312(7044):1478. Unique Identifier : AIDSLINE MED/96257117; Grazioli A
Using condoms to prevent transmission of HIV. Condoms have an appreciable failure rate [letter]: BMJ. 1996 Jun 8;312(7044):1478. Unique Identifier : AIDSLINE MED/96257116; Kelly J
The rights of HIV infected healthcare workers [editorial; comment]: BMJ. 1996 Jun 29;312(7047):1625-6. Unique Identifier : AIDSLINE MED/96266812; Erridge P
Drug users and people with HIV infection need better care in prison [letter]: BMJ. 1996 Jun 29;312(7047):1671. Unique Identifier : AIDSLINE MED/96266848; Ford C
Coming out--a personal dilemma [see comments]: BMJ. 1996 Jun 29;312(7047):1679. Unique Identifier : AIDSLINE MED/96303124; Logie S
A new short form individual quality of life measure (SEIQoL-DW): application in a cohort of individuals with HIV/AIDS [see comments]: BMJ. 1996 Jul 6;313(7048):29-33. Unique Identifier : AIDSLINE MED/96280568; Hickey AM; Bury G; O'Boyle CA; Bradley F; O'Kelly FD; Shannon W; Department of General Practice, University College Dublin, Coombe; Healthcare Centre, Republic of Ireland.; Quality of life is an increasingly important outcome measure in medicine and health care. Many measures of quality of life present patients with predetermined lists of questions that may or may not be relevant to the individual patient. This paper describes a brief measure, the SEIQoL-DW, which is derived from the sch
The HIV-tobacco theorem [letter]: Natl Med J India. 1996 May-Jun;9(3):144. Unique Identifier : AIDSLINE MED/96267972; Vaidya JS
Mycobacterium avium disease: progress at last [editorial; comment]: Am J Respir Crit Care Med. 1996 Jun;153(6 Pt 1):1737-8. Unique Identifier : AIDSLINE MED/96279756; Bates JH
Clarithromycin regimens for pulmonary Mycobacterium avium complex. The first 50 patients [see comments]: Am J Respir Crit Care Med. 1996 Jun;153(6 Pt 1):1766-72. Unique Identifier : AIDSLINE MED/96279759; Wallace RJ Jr; Brown BA; Griffith DE; Girard WM; Murphy DT; The Center for Pulmonary Infectious Disease Control, University; of Texas Health Center, Tyler, Texas 75710, USA.; Intermediate results of the first 50 patients treated with clarithromycin (CLARI) regimens for Mycobacterium avium-intracellulare (MAI) lung disease were evaluated. Patients were HIV negative, and pretreatment isolates were susceptible to CLARI. Patients received CLARI 500 mg twice daily, ethambutol, rifampin (RMP), o
Predictors of survival in human immunodeficiency virus-infected patients with pulmonary tuberculosis. The Makerere University-Case Western Reserve University Research Collaboration.: Am J Respir Crit Care Med. 1996 Jun;153(6 Pt 1):1977-81. Unique Identifier : AIDSLINE MED/96279791; Whalen C; Okwera A; Johnson J; Vjecha M; Hom D; Wallis R; Huebner R; Mugerwa R; Ellner J; Department of Epidemiology and Biostatistics, Case Western; Reserve University School of Medicine, Cleveland, Ohio; 44106-4945, USA.; Infection with the human immunodeficiency virus (HIV) has changed both the epidemiology and natural history of tuberculosis. Despite a generally good response to effective antituberculous therapy, the prognosis remains poor. The objective of this analysis was to determine the independent predictors of survival in HIV-
Reliability of anergy skin testing in persons with HIV infection. The pulmonary Complications of HIV Infection Study Group.: Am J Respir Crit Care Med. 1996 Jun;153(6 Pt 1):1982-4. Unique Identifier : AIDSLINE MED/96279792; Chin DP; Osmond D; Page-Shafer K; Glassroth J; Rosen MJ; Reichman LB; Kvale PA; Wallace JM; Poole WK; Hopewell PC; University of California, San Francisco, California, USA.; Testing with antigens that elicit delayed-type cutaneous hypersensitivity reactions is commonly used to evaluate immune competence in persons infected with the human immunodeficiency virus; however, the reliability of such testing has not been determined. We performed serial testing with tuberculin, mumps, and Candida
Heterosexual HIV transmission.: Infect Agents Dis. 1995 Dec;4(4):273-84. Unique Identifier : AIDSLINE MED/96263671; Mayer KH; Anderson DJ; Department of Medicine and Community Health, Brown University; School of Medicine, Memorial Hospital of Rhode Island, Pawtucket,; Rhode Island 02860, USA.; Most of the people now living with HIV acquired the infection through heterosexual intercourse. HIV transmission has been facilitated by (a) concomitant sexually transmitted diseases (STDs), (b) the presence of social conditions that create core groups who have frequent and numerous partners, (c) sexual practices asso
Some practical aspects of double-resonance techniques in solution-state NMR studies of high-molecular-weight systems.: J Magn Reson B. 1996 May;111(2):135-48. Unique Identifier : AIDSLINE MED/96228756; Tsang P; Rance M; Department of Chemistry, University of Cincinnati, Ohio 45221,; USA.; This paper addresses some of the practical issues associated with solution NMR investigations of high-molecular-weight ( > 20 kDa) biomolecules and their complexes. The experimental example of a high-molecular-weight system used here is a 52 kDa Fab/peptide complex. Theoretical as well as experimental aspects of solut
Oral Mycobacterium avium complex infection in a patient with HIV-related disease. A case report.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996 Feb;81(2):177-9. Unique Identifier : AIDSLINE MED/96221024; Robinson P; Farthing P; Scott GM; Bennett JH; Camden and Islington Community Health Service NHS Trust, London,; UK.; Mycobacterium avium complex infection is a common complication of the later stages of AIDS. Although a recognized cause of oral lesions, atypical mycobacteria are rarely detected in AIDS-related oral ulceration. Here we report a case of oral ulceration in a patient in the later stages of AIDS in which atypical mycobac
Serotype analysis of Indian patients with HIV infection.: Trop Med Int Health. 1996 Apr;1(2):199-204. Unique Identifier : AIDSLINE MED/96273060; Sehgal S; Pasricha N; Jamil S; Department of Immunopathology, Postgraduate Institute of Medical; Education and Research, Chandigarh, New Delhi.; HIV infection has established itself in India . Besides Bombay, Madras and Manipur it has assumed epidemic proportions in Punjab, where 24% of seropositives acquired infection through blood products. Preliminary observations on genetic analysis in 13 isolates revealed that the princi
Seroepidemiological study of retroviruses (HTLV-I/II, HIV-1, HIV-2) in the Department of Atacora, northern Benin.: Trop Med Int Health. 1996 Apr;1(2):205-9. Unique Identifier : AIDSLINE MED/96273061; Houinato D; Verdier M; Josse R; Zohoun T; Letenneur L; Salamon R; Denis F; Preux PM; Institut d'Epidemiologie Neurologique et de Neurologie; Tropicale, Faculte de Medecine, Universite de Limoges, France.; A seroepidemiological survey to determine the prevalence of retrovirus infection (HTLV-I/II, HIV-1, HIV-2) by representative sampling of the general population in the Department of Atacora in north-western Benin is reported. The seroprevalence rate of HTLV-I in this sample was at 1.
High HIV seroprevalence among patients with pyomyositis in northern Uganda.: Trop Med Int Health. 1996 Apr;1(2):210-2. Unique Identifier : AIDSLINE MED/96273062; Ansalonl L; Acaye GL; Re MC; Dr Ambrosoli Memorial Hospital, Kalongo, Kitgum District, Uganda.; With the aim of correlating pyomyositis with HIV infection, we have carried out a case-control comparison of HIV seroprevalence among patients affected by pyomyositis and an age and sex-matched control group of healthy subjects. Over a one-year period, 35 patients with pyomyositis, 20 male and 15 female, mean age 28.3
Update of HIV and AIDS in North America.: Med Health R I. 1996 May;79(5):180-7. Unique Identifier : AIDSLINE MED/96267903; Flanigan TP; Uvin SC; Rich JD; Mileno MD; Vigilante K; Tashima K; Division of Geographic Medicine and Clinical Immunology, Miriam; Hospital, Providence, RI 02906, USA.; The second wave of the HIV epidemic, which increasingly affects injection drug users, women, and minorities, necessitates the development of primary care HIV services so that these individuals may benefit from new therapies. The ability to dramatically decrease vertical transmission of HIV from mother to child with an
Cryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformans.: Clin Microbiol Rev. 1995 Oct;8(4):515-48. Unique Identifier : AIDSLINE MED/96114210; Mitchell TG; Perfect JR; Department of Microbiology, Duke University Medical Center,; Durham, North Carolina 27710, USA.; Although Cryptococcus neoformans and cryptococcosis have existed for several millennia, a century has passed since the discovery of this encapsulated yeast and its devastating disease. With the advent of the AIDS pandemic, cryptococcal meningitis has emerged as a leading cause of infectious morbidity and mortality and
Molecular biology and pathogenesis of animal lentivirus infections.: Clin Microbiol Rev. 1996 Jan;9(1):100-17. Unique Identifier : AIDSLINE MED/96263589; Clements JE; Zink MC; Division of Comparative Medicine, Johns Hopkins University School; of Medicine, Baltimore, Maryland, USA.; Lentiviruses are a subfamily of retroviruses that are characterized by long incubation periods between infection of the host and the manifestation of clinical disease. Human immunodeficiency virus type 1, the causative agent of AIDS, is the most widely studied lentivirus. However, the lentiviruses that infect sheep, g
Human endogenous retroviruses: nature, occurrence, and clinical implications in human disease.: Clin Microbiol Rev. 1996 Jan;9(1):72-99. Unique Identifier : AIDSLINE MED/96263588; Urnovitz HB; Murphy WH; Calypte Biomedical Corporation, Berkeley, California 94710, USA.; hervdoc@aol.com; Retroviral diagnostics have become standard in human laboratory medicine. While current emphasis is placed on the human exogenous viruses (human immunodeficiency virus and human T-cell leukemia virus), evidence implicating human endogenous retroviruses (HERVs) in various human disease entities continues to mount. Lite
High expression of ganglioside alpha-2,8-sialyltransferase (GD3 synthase) gene in adult T-cell leukemia cells unrelated to the gene expression of human T-lymphotropic virus type I.: Cancer Res. 1996 Jun 15;56(12):2844-8. Unique Identifier : AIDSLINE MED/96275759; Okada M; Furukawa K; Yamashiro S; Yamada Y; Haraguchi M; Horibe K; Kato K; Tsuji Y; Furukawa K; Department of Oncology, Internal Medicine, Atomic Bomb Disease; Institute, Nagasaki, Japan.; Expression of ganglioside alpha-2,8-sialyltransferase (GD3 synthetase; EC 2.4.99.8) gene and gangliosides in human leukemia cells were analyzed. Flow cytometric analysis of various types of leukemia cells using monoclonal antibodies revealed that GD3 was expressed at a moderate level on adult T-cell leukemia (ATL) cel
Diverse manifestations of tumorigenicity and immunogenicity displayed by the poorly immunogenic B16-BL6 melanoma transduced with cytokine genes.: Cancer Immunol Immunother. 1996 May;42(4):237-45. Unique Identifier : AIDSLINE MED/96265094; Arca MJ; Krauss JC; Strome SE; Cameron MJ; Chang AE; Department of Surgery, University of Michigan, Ann Arbor 48109,; USA.; We evaluated the in vivo response to the poorly immunogenic B16-BL6 (BL6) murine melanoma genetically altered to secrete interleukin-2 ( IL-2 ), IL-4, interferon gamma (IFN gamma) and granulocyte/macrophage-colony-stimulating factor (GM-CSF). Three parameters were evalua
Dendritic cells in antitumor immune responses. II. Dendritic cells grown from bone marrow precursors, but not mature DC from tumor-bearing mice, are effective antigen carriers in the therapy of established tumors.: Cell Immunol. 1996 May 25;170(1):111-9. Unique Identifier : AIDSLINE MED/96216581; Gabrilovich DI; Nadaf S; Corak J; Berzofsky JA; Carbone DP; Simmons Cancer Center, UT Southwestern Medical Center, Dallas,; Texas, USA.; Antitumor CTL responses were studied in a model tumor hearing a mutant human p53 gene. We found ineffective induction of antitumor CTL in mice bearing these tumors associated with measurable defects in the function of dendritic cells (DC) from these animals. In this study we investigate the mechanism of this defect in
Impaired IgG production in the lungs of HIV-infected individuals.: Cell Immunol. 1996 May 25;170(1):127-33. Unique Identifier : AIDSLINE MED/96216583; Twigg HL 3rd; Spain BA; Soliman DM; Bowen LK; Heidler KM; Wilkes DS; Department of Medicine, Division of Pulmonary and Critical Care; Medicine, Indiana University Medical Center, Indianapolis 46202,; USA.; Human immunodeficiency virus (HIV)-infected individuals are at risk for pulmonary infections with encapsulated bacterial pathogens. This could reflect impaired production of opsonizing antibodies in the lower respiratory tract. We examined antibody production in the alveolar space by measuring immunoglobulin concentra
[HIV therapy with drug combinations (news)]: Dtsch Med Wochenschr. 1996 Jun 21;121(25-26):A36. Unique Identifier : AIDSLINE MED/96303125; Rass H
Nucleocapsid protein 10 activates dimerization of the RNA of Moloney murine leukaemia virus in vitro.: Eur J Biochem. 1996 May 15;238(1):129-35. Unique Identifier : AIDSLINE MED/96248430; Bonnet-Mathoniere B; Girard PM; Muriaux D; Paoletti J; Unite de Biochimie, URA 147 CNRS, Institut Gustave Roussy,; Villejuif, France.; Short RNA species that encompass the psi domain of the retroviral genome spontaneously form dimers in vitro, and the retroviral nucleocapsid protein activates this dimerization in vitro. Addition of gag RNA sequences downstream of the 3 end of the psi domain decreases the level of spontaneous dimerization. Here, we r
The subcellular distribution of eukaryotic translation initiation factor, eIF-5A, in cultured cells.: Exp Cell Res. 1996 Jun 15;225(2):348-56. Unique Identifier : AIDSLINE MED/96251057; Shi XP; Yin KC; Zimolo ZA; Stern AM; Waxman L; Department of Biological Chemistry, Merck Research Laboratories,; West Point, Pennsylvania 19486, USA.; To gain insight into the role of the eukaryotic translation initiation factor, eIF-5A, we investigated the subcellular distribution of this protein in several cultured cell types and at different stages of the cell cycle using a highly potent monospecific polyclonal antibody to eIF-5A. Studies using indirect immunoflu
How many children with HIV? [news]: Fam Plann Perspect. 1995 Nov-Dec;27(6):226. Unique Identifier : AIDSLINE MED/96255675; Davis SF
Women, hiv and condom use [news]: Fam Plann Perspect. 1995 Nov-Dec;27(6):226-7. Unique Identifier : AIDSLINE MED/96255676; Diaz T
Parent and peer communication effects on AIDS-related behavior among U.S. high school students.: Fam Plann Perspect. 1995 Nov-Dec;27(6):235-40, 268. Unique Identifier : AIDSLINE MED/96255678; Holtzman D; Rubinson R; Office of Surveillance and Analysis, Centers for Disease Control; and Prevention, Atlanta, Ga, USA.; Data from a 1989 national probability sample of 8,098 high school students in the United States indicate that young people s discussions about the human immunodeficiency virus (HIV) with parents and with peers are highly correlated and have opposite effects on behavior. Students who di
Multiple partners, risky partners and HIV risk among low-income urban women.: Fam Plann Perspect. 1995 Nov-Dec;27(6):241-5. Unique Identifier : AIDSLINE MED/96255679; Wagstaff DA; Kelly JA; Perry MJ; Sikkema KJ; Solomon LJ; Heckman TG; Anderson ES; Center for AIDS Intervention Research, Medical College of; Wisconsin, Milwaukee, USA.; A sample of 671 predominantly single, young black women living in 10 low-income housing developments in five cities completed an anonymous questionnaire assessing factors related to their risk of contracting the human immunodeficiency virus, including their sexual behavior and condom use, and their partners risk-rela
Cellular and molecular mechanisms in the pathogenesis of severe pulmonary hypertension.: Eur Respir J. 1995 Dec;8(12):2129-38. Unique Identifier : AIDSLINE MED/96263901; Voelkel NF; Tuder RM; Dept of Medicine and Pathology, University of Colorado Health; Sciences Center, Denver, CO 80262, USA.; Chronic pulmonary hypertension leads to structural alterations of the lung vessels. The pathophysiology of this remodelling process is still poorly understood. Furthermore, the structural damage of the lung vessels limits the clinical success of vasodilator treatment. Given a genetic susceptibility, shear stress and i
Activator-dependent regulation of transcriptional pausing on nucleosomal templates.: Genes Dev. 1996 Jun 15;10(12):1479-90. Unique Identifier : AIDSLINE MED/96258249; Brown SA; Imbalzano AN; Kingston RE; Department of Genetics, Harvard Medical School, Boston,; Massachusetts 02114, USA.; Promoter-proximal pausing during transcriptional elongation is an important way of regulating many diverse genes, including human c-myc and c-fos, some HIV genes, and the Drosophila heat shock loci. To characterize the mechanisms that regulate pausing, we have established an in vitro system using the human hsp7O gene.
Retroviral vectors designed for targeted expression of RNA polymerase III-driven transcripts: a comparative study.: Gene. 1996 Jun 1;171(2):203-8. Unique Identifier : AIDSLINE MED/96257220; Ilves H; Barske C; Junker U; Bohnlein E; Veres G; Systemix Inc., Department of Molecular Therapy, Palo Alto, CA; 94304, USA.; Retroviral gene delivery systems for RNA polymerase II (RNA pol II)-based promoters have been developed and are widely used in gene transfer studies. In contrast, gene delivery systems with RNA pol III-based expression cassettes have not been studied comprehensively, although therapeutic applications (e.g., ribozymes,
Hepatitis C in human immunodeficiency virus-coinfected patients: increased variability in the hypervariable envelope coding domain.: Hepatology. 1996 Apr;23(4):688-94. Unique Identifier : AIDSLINE MED/96230088; Sherman KE; Andreatta C; O'Brien J; Gutierrez A; Harris R; Department of Medicine and Pathology, University of Cincinnati; Medical Center, OH, USA.; Patients coinfected with the hepatitis C virus (HCV) and the human immunodeficiency virus (HIV) were studied with regard to nucleotide sequence variability in the E2/NS1 first hypervariable region of the HCV genome. The nucleotide variability within individual patients was compared to patients infected only with HCV.
Etiology, evaluation, and outcome of jaundice in patients with acquired immunodeficiency syndrome.: Hepatology. 1996 Apr;23(4):728-33. Unique Identifier : AIDSLINE MED/96230095; Chalasani N; Wilcox CM; Department of Medicine (Division of Digestive Diseases), Emory; University School of Medicine, Atlanta, Georgia, USA.; Although liver test abnormalities are frequently identified in patients with acquired immunodeficiency syndrome (AIDS), the causes, evaluation, and outcome of jaundice in these patients have not been systematically evaluated. From August 1, 1990 through September 1, 1994, all human immunodeficiency virus (HIV)-infecte
In situ amplification and detection of HIV-1 DNA in fixed pediatric AIDS brain tissue.: Hum Pathol. 1996 Jun;27(6):614-7. Unique Identifier : AIDSLINE MED/96251229; Sharer LR; Saito Y; Da Cunha A; Ung PC; Gelbard HA; Epstein LG; Blumberg BM; Department of Pathology, New Jersey Medical School, Newark 07103,; USA.; To examine whether latent infection by HIV-1 occurs in the central nervous system, we optimized a procedure for amplification and detection of HIV-1 DNA in situ, in formalin-fixed brain tissue from a child with severe HIV-1-associated progressive encephalopathy and severe HIV-1 encephalitis. By the use of a two-step t
Type-1 and type-2 CD8+ T-cell subsets isolated from chronic adult periodontitis tissue differ in surface phenotype and biological functions.: Immunology. 1996 Jan;87(1):113-8. Unique Identifier : AIDSLINE MED/96264101; Wassenaar A; Reinhardus C; Abraham-Inpijn L; Kievits F; Department of General Pathology and Internal Medicine, University; of Amsterdam, Netherlands.; Cloning of CD8+ T cells expressing the alpha beta T-cell receptor from inflamed human gingiva revealed that at least two different subsets were found within the tissue and that these subsets were able to interact with each other. One subset produced high levels of interferon-gamma (IFN-gamma) and no interleukin-4 (IL-
Limiting dilution analysis of CD4 T-cell cytokine production in mice administered native versus polymerized ovalbumin: directed induction of T-helper type-1-like activation.: Immunology. 1996 Jan;87(1):119-26. Unique Identifier : AIDSLINE MED/96264102; Gieni RS; Yang X; Kelso A; Hayglass KT; Department of Immunology, University of Manitoba, Winnipeg,; Canada.; Polarized expression of T-helper type-1 (Th1)- or Th2-like patterns of cytokine production frequently correlates with disease outcome. Previously, we have described the long-lived reciprocal regulation of ovalbumin (OVA)-specific IgE (> 95% inhibition) and IgG2a (300-800-fold increased) production following administra
Suppression of T-helper type-1 immune response against Listeria monocytogenes by treatment of mice with goat antibodies to mouse IgD.: Immunology. 1996 Jan;87(1):15-20. Unique Identifier : AIDSLINE MED/96264087; Matsuzaki G; Song F; Nomoto K; Department of Immunology, Medical Institute of Bioregulation,; Kyushu University, Fukuoka, Japan.; Injection of goat anti-mouse IgD antibodies (GAM IgD) to mice has been shown to induce polyclonal IgG1 and IgE production by B cells and interleukin-4 (IL-4) production by goat Ig-specific T cells. Surface IgD cross-linking also activates B cells to function as antigen-presenting cells (APC). Although the GAM IgD trea
Differential usage of T-cell receptor V beta gene families by CD4+ and CD8+ T cells in patients with CD8hi common variable immunodeficiency: evidence of a post-thymic effect.: Immunology. 1996 Jan;87(1):99-107. Unique Identifier : AIDSLINE MED/96264099; Duchmann R; Jaffe J; Ehrhardt R; Alling DW; Strober W; First Department of Internal Medicine, University of Mainz,; Germany.; In this study, we report that differences between T-cell receptor (TCR) V beta gene family usage in CD4+ and CD8+ T cells are significantly greater in a subgroup of patients with common variable immunodeficiency (CVI) and high levels of activated CD8+ T cells (CD8hi CVI) than in controls (P
An integrated rule- and case-based approach to AIDS initial assessment.: Int J Biomed Comput. 1996 Jan;40(3):197-207. Unique Identifier : AIDSLINE MED/96243973; Xu LD; Department of MSIS, Wright State University, Dayton, OH 45435,; USA.; The traditional approach to the development of knowledge-based systems (KBS) has been rule-based, where heuristic knowledge is encoded in a set of production rules. A rule-based reasoning (RBR) system needs a well constructed domain theory as its reasoning basis, and it does not make substantial use of the knowledge e
AIDS-related conditions: study of a representative sample of 1203 patients deceased in 1992 in France.: Int J Epidemiol. 1996 Feb;25(1):190-7. Unique Identifier : AIDSLINE MED/96237161; Jougla E; Pequignot F; Carbon C; Pavillon G; Mireille EB; Bourdais JP; Bourdais O; Hatton F; Service d'Information sur les Causes Medicales de Deces,; Institut National de la Sante et de la Recherche Medicale; (INSERM-SC8), Le Vesinet, France.; BACKGROUND. Little representative information exists on the frequency of human immunodeficiency virus (HIV)-related diseases among the overall AIDS population. The objective of this research is to assess the nature, frequency and characteristics of these diseases among AIDS patients during their last year of life and
Prevalence of antibiotics to hepatitis C in a population of intravenous drug users in Valencia, Spain, 1990-1992.: Int J Epidemiol. 1996 Feb;25(1):204-9. Unique Identifier : AIDSLINE MED/96237163; Bolumar F; Hernandez-Aguado I; Ferrer L; Ruiz I; Avino MJ; Rebagliato M; Departamento de Salud Publica, Universidad de Alicante, Spain.; BACKGROUND. Hepatitis C has been related to other viral diseases such as the human immunodeficiency virus infection (HIV) or hepatitis B (HBV). The objective of this study was to estimate the prevalence and determinants of antibodies to hepatitis C virus (HCV) in intravenous drug users (IVDU) in Valencia (
Hepatitis B virus core particles as epitope carriers.: Intervirology. 1995;38(1-2):63-74. Unique Identifier : AIDSLINE MED/96263877; Pumpens P; Borisova GP; Crowther RA; Grens E; Biomedical Research and Study Centre, University of Latvia, Riga.; HBV core (HBc) particle is one of the most intensively studied particulate carriers for the insertion of foreign peptide sequences. Recombinant HBc protein expressed from the cloned gene undergoes the correct folding in a large variety of bacterial, yeast, insect and mammalian cells. Unique assembly properties and sha
Lymphocytes induce enhanced expression of HLA class I antigens on cytomegalovirus-infected syngeneic human endothelial cells.: Hum Immunol. 1995 Nov;44(3):136-44. Unique Identifier : AIDSLINE MED/96245598; Scholz M; Blaheta RA; Cinatl J; Encke A; Doerr HW; Markus BH; Johann Wolfgang Goethe-University, Department of General Surgery,; Frankfurt am Main, Germany.; Human cytomegalovirus (HCMV) infection has been associated with enhanced expression of HLA antigens on the endothelium and with cellular infiltrates within the graft following human organ transplantation. We investigated the interactions between human cytomegalovirus-infected cultu
Genetic predisposition to HIV-1 infection and acquired immune deficiency virus syndrome A review of the literature examining associations with HLA.: Hum Immunol. 1995 Nov;44(3):156-69. Unique Identifier : AIDSLINE MED/96245600; Just JJ; School of Public Health, University of California, Berkeley, USA.; Researchers have been studying the relationship between host HLA type and the immune response to HIV-1 since early in the AIDS epidemic. Although the literature is replete with suggestions of an association, the exact locus and nature is unclear. This article reviews the current HLA-HIV/AIDS literature, providing a co
Multiple cis-elements mediate shear stress-induced gene expression.: J Biomech. 1995 Dec;28(12):1451-7. Unique Identifier : AIDSLINE MED/96235737; Shyy JY; Li YS; Lin MC; Chen W; Yuan S; Usami S; Chien S; Department of Bioengineering, University of California, La Jolla; 92093-0412, USA. Schien@bioeng.ucsd.edu.; Fluid shear stress activates the expression of immediate early (IE) genes in vascular endothelial cells. The transcriptional regulation can be mediated through the shear stress-sensitive cis-acting elements at the 5 promoter regions of various IE genes such as the monocyte chemotactic protein-1 (MCP-1) gene. We linke
Detection by PCR of Toxoplasma gondii in blood in the diagnosis of cerebral toxoplasmosis in patients with AIDS.: J Clin Pathol. 1996 Jan;49(1):89-92. Unique Identifier : AIDSLINE MED/96264339; Lamoril J; Molina JM; de Gouvello A; Garin YJ; Deybach JC; Modai J; Derouin F; Laboratoire de Biochimie, Hopital Louis-Mourier, Colombes,; France.; The polymerase chain reaction (PCR) for amplification of Toxoplasma gondii DNA was performed prospectively in the blood of 19 patients with AIDS and cerebral toxoplasmosis. The B1 gene and TGR1E sequence were used as targets and results were confirmed by hybridisation. Controls consisted of 24 HIV infected patients wi
Questing for grails: duplicity, betrayal and self-deception in postmodern medical research.: J Contemp Health Law Policy. 1996 Spring;12(2):297-324. Unique Identifier : AIDSLINE MED/96250835; Annas GJ; Health Law Department, Boston University School of Medicine, USA.
Epicutaneous exposure of protein antigen induces a predominant Th2-like response with high IgE production in mice.: J Immunol. 1996 Jun 1;156(11):4077-82. Unique Identifier : AIDSLINE MED/96247620; Wang LF; Lin JY; Hsieh KH; Lin RH; Graduate Institute of Microbiology, College of Medicine, National; Taiwan University, Taipei, Taiwan, Republic of China.; Hapten-induced contact hypersensitivity has been well-characterized in humans as well as in animal models. However, it is not clear whether or not protein Ag can directly sensitize epicutaneously and induce a primary immune response. We demonstrated in this study, for the first time, that through epicutaneous exposure
TCR-independent activation of human CD4+ 45RO- T cells by anti-CD28 plus IL-2: Induction of clonal expansion and priming for a Th2 phenotype.: J Immunol. 1996 Jun 1;156(11):4100-6. Unique Identifier : AIDSLINE MED/96247623; Brinkmann V; Kinzel B; Kristofic C; Department of Asthma and Allergy Research, Pharmaceuticals; Division, Ciba-Geigy Limited, Basel, Switzerland.; In this study we show that uncommitted human CD4+ CD45RA+ RO- CD25- CD71- HLA-DR- T cells can be primed for a Th2 phenotype before they encounter TCR signals and before they are exposed to IL-4. We found that >99% of uncommitted T cells proliferated upon costimulation by immobilized anti-CD3 plus anti-CD28 mAbs and di
TAP-independent selection of CD8+ intestinal intraepithelial lymphocytes.: J Immunol. 1996 Jun 1;156(11):4209-16. Unique Identifier : AIDSLINE MED/96247637; Sydora BC; Brossay L; Hagenbaugh A; Kronenberg M; Cheroutre H; Department of Microbiology and Immunology and the Molecular; Biology Institute, University of California at Los Angeles, CA; 90095, USA.; Intestinal intraepithelial lymphocytes (IEL) are mostly CD8 single positive T cells. IEL with a TCR-alpha(beta) that are CD8 single positive are absent from beta(2)-microglobulin (beta(2)m)-deficient mice, consistent with the idea that these IEL, like other TCR-alpha(beta)+, CD8+ T cells, require class I molecules for
Genetically determined differences in IL-10 and IFN-gamma responses correlate with clearance of Chlamydia trachomatis mouse pneumonitis infection.: J Immunol. 1996 Jun 1;156(11):4338-44. Unique Identifier : AIDSLINE MED/96247653; Yang X; HayGlass KT; Brunham RC; Department of Medical Microbiology, University of Manitoba,; Winnipeg, Manitoba, Canada.; Cytokine patterns elicited by infection are critical in the regulation of the adaptive immune response and in the resolution of infection. Using a murine model of pneumonia induced by intranasal inoculation with the Chlamydia trachomatis mouse pneumonitis (MoPn) biovar, we found that the patterns of immune responses a
Identification of multiple and distinct CD8+ T cell suppressor activities: dichotomy between infected and uninfected individuals, evolution with progression of disease, and sensitivity to gamma irradiation.: J Immunol. 1996 Jun 1;156(11):4476-83. Unique Identifier : AIDSLINE MED/96247671; Barker TD; Weissman D; Daucher JA; Roche KM; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892, USA.; Using an in vitro model system that reflects the cellular interactions occurring in the microenvironment of lymphoid organs (i.e., the interaction between dendritic cells (DC) and CD4+ T lymphocytes), the ability of CD8+ T cells to inhibit HIV replication was investigated. DC, the most potent APC in the paracortical r
Role of IL-12 in peripheral blood mononuclear cell responses to fungi in persons with and without HIV infection.: J Immunol. 1996 Jun 1;156(11):4492-7. Unique Identifier : AIDSLINE MED/96247673; Harrison TS; Levitz SM; The Evans Memorial Department of Clinical Research and Department; of Medicine, Boston University Medical Center Hospital, MA 02118; Clinical trials of IL-12 in persons infected with HIV have been proposed based on recent evidence suggesting IL-12 plays a critical role in the development of protective immune responses, and the HIV infection is associated with a deficiency of IL-12. As fungal infections are among the most common opportunistic infect
Collagen-induced arthritis in CD4- or CD8-deficient mice: CD8+ T cells play a role in initiation and regulate recovery phase of collagen-induced arthritis.: J Immunol. 1996 Jun 1;156(11):4520-6. Unique Identifier : AIDSLINE MED/96247677; Tada Y; Ho A; Koh DR; Mak TW; Amgen Institute, Ontario Cancer Institute, Ontario, Canada.; Collagen-induced arthritis (CIA) is an experimental autoimmune disease induced by immunization with collagen type II (CII). We studied CIA in CD4- or CD8-deficient DBA/1 mice to further define the roles of CD4+ and CD8+ T cells in the disease. CD4-deficient mice developed severe arthritis, and no differences in incide
Detection and quantification of blood-derived CD8+ T lymphocytes secreting tumor necrosis factor alpha in response to HLA-A2.1-binding melanoma and viral peptide antigens.: J Immunol Methods. 1996 May 27;191(2):131-42. Unique Identifier : AIDSLINE MED/96251682; Herr W; Schneider J; Lohse AW; Meyer zum Buschenfelde KH; Wolfel T; Medizinische Klinik, Johannes Gutenberg-Universitat Mainz,; Germany.; We applied an enzyme-linked immunospot (ELISPOT) assay for the detection and quantification of blood-derived CD8+ T cells recognizing peptide antigens presented by HLA-A2.1. CD8+ T lymphocytes were isolated from peripheral blood and were stimulated for 40 h with peptide-loaded A2.1-positive 0.174 x CEM.T2 cells. Tumor
Antibodies to p24 antigen do not specifically detect HIV-infected lymphocytes in AIDS patients.: J Immunol Methods. 1996 May 27;191(2):179-86. Unique Identifier : AIDSLINE MED/96251687; Kux A; Bertram S; Hufert FT; Schmitz H; von Laer D; Abteilung Virologie, Universitat Freiburg, Germany.; A flow cytometric assay (FCA), which detects the p24 antigen in HIV-infected cell lines and in peripheral blood mononuclear cells (PBMC) of AIDS patients, has been described in several studies. However, the results presented here clearly show that this p24-FCA, although useful for the analysis of HIV infection of cell
The impact of bacteraemia on HIV infection. Nine years experience in a large Italian university hospital.: J Infect. 1995 Sep;31(2):123-31. Unique Identifier : AIDSLINE MED/96116157; Tumbarello M; Tacconelli E; Caponera S; Cauda R; Ortona L; Department of Infectious Diseases, Catholic University, Rome,; Italy.; The object of this case control study was to evaluate the frequency, the risk factors, the microbiological spectrum and the outcome of 249 cases of bacteraemia observed in 209 HIV-infected patients, most them affected by AIDS. The rate of bacteraemia in the total yearly HIV-related admissions increased from 4% in 1985
Circulating levels of mannose binding protein in human immunodeficiency virus infection.: J Infect. 1995 Sep;31(2):145-8. Unique Identifier : AIDSLINE MED/96116160; Senaldi G; Davies ET; Mahalingam M; Lu J; Pozniak A; Peakman M; Reid KB; Vergani D; WHO-Immunology Research and Training Centre, Department of; Pathology, University of Geneva, Switzerland.; Mannose binding protein (MBP) is a serum lectin which, upon binding to a carbohydrate extremity, acquires the ability to activate the classical complement pathway. MBP binds human immunodeficiency virus (HIV) in vitro via glycans on gp120 and thus, it may play a defensive role in HIV infection and contribute to virus
HIV-2 infection with a long asymptomatic period.: J Infect. 1995 Sep;31(2):163-4. Unique Identifier : AIDSLINE MED/96116166; Mota-Miranda A; Gomes H; Marques R; Serrao R; Lourenco H; Santos-Ferreira O; Lecour H; Infectious Diseases Service, School of Medicine, Hospital Sao; Joao, Porto, Portugal.; We give details of a patient infected with HIV-2 which had what we believe to be the longest asymptomatic period so far reported. The infection was probably acquired though a blood transfusion in Africa 27 years ago. At present the patient remains asymptomatic and her cellular defence mechanisms, evaluated by CD+4 lym
Parapharyngeal abscess from Pseudomonas aeruginosa infection in an HIV positive patient [letter]: J Infect. 1995 Sep;31(2):174. Unique Identifier : AIDSLINE MED/96116171; Sanderson RJ; Anstey ST
Better efficacy of twice-monthly than monthly aerosolised pentamidine for secondary prophylaxis of Pneumocystis carinii pneumonia in patients with AIDS. An Italian multicentric randomised controlled trial. The Italian PCP Study Group.: J Infect. 1995 Sep;31(2):99-105. Unique Identifier : AIDSLINE MED/96116154; Rizzardi GP; Lazzarin A; Musicco M; Frigerio D; Maillard M; Lucchini M; Moroni M; Institute of Internal Medicine, Infectious Diseases and; Immunopathology, University of Milan, Italy.; The aim of this multicentric randomised controlled trial was to evaluate long-term efficacy and safety of once-monthly versus twice-monthly 300 mg aerosolized pentamidine (AP) as secondary prophylaxis of Pneumocystis carinii pneumonia (PCP). We randomised 205 patients with a previous confirmed episode of PCP (107 trea
Central role of immunoglobulin (Ig) E in the induction of lung eosinophil infiltration and T helper 2 cell cytokine production: inhibition by a non-anaphylactogenic anti-IgE antibody.: J Exp Med. 1996 Apr 1;183(4):1303-10. Unique Identifier : AIDSLINE MED/96261632; Coyle AJ; Wagner K; Bertrand C; Tsuyuki S; Bews J; Heusser C; Ciba-Geigy Ltd., Asthma and Allergy Research Department,; Pharmaceutical Division, Basel Switzerland.; Elevated levels of immunoglobulin (Ig) E are associated with bronchial asthma, a disease characterized by eosinophilic inflammation of the airways. Activation of antigen-specific T helper (Th) 2 cells in the lung with the subsequent release of interleukin (IL) 4 and IL-5 is believed to play an important role in the pa
Impaired neutrophil response and CD4+ T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans.: J Exp Med. 1996 Apr 1;183(4):1345-55. Unique Identifier : AIDSLINE MED/96261637; Romani L; Mencacci A; Cenci E; Spaccapelo R; Toniatti C; Puccetti P; Bistoni F; Poli V; Microbiology Section, Department of Experimental Medicine and; Biomedical Sciences, University of Perugia, Italy.; To define the role of interleukin (IL)6 in Candida albicans infection, IL-6 deficient mice were assessed for susceptibility to systemic or gastrointestinal infection, as well as for parameters of elicited T helper cell (Th) immunity. IL-6-deficient mice were more susceptible than wild-type mice to either type of infec
Visualization, characterization, and turnover of CD8+ memory T cells in virus-infected hosts.: J Exp Med. 1996 Apr 1;183(4):1367-75. Unique Identifier : AIDSLINE MED/96261639; Zimmerman C; Brduscha-Riem K; Blaser C; Zinkernagel RM; Pircher H; Institute for Medical Microbiology and Hygiene, Department of; Immunology, University of Freiburg, Germany.; The cellular basis of T cell memory is a controversial issue and progress has been hampered by the inability to induce and to trace long-term memory T cells specific for a defined antigen in vivo. By using the murine model of lymphocytic choriomeningitis virus (LCMV) infection and an adoptive transfer system with CD8+
Distinct regulatory roles of lymphocyte costimulatory pathways on T helper type-2 mediated autoimmune disease.: J Exp Med. 1996 Apr 1;183(4):1473-81. Unique Identifier : AIDSLINE MED/96261649; Biancone L; Andres G; Ahn H; Lim A; Dai C; Noelle R; Yagita H; De Martino C; Stamenkovic I; Department of Pathology, Harvard Medical School, Boston,; Massachusetts 02129, USA.; We assessed the role of CD40-CD40L, cytotoxic T lymphocyte (CTL)A4/CD28-B7s, and CD2-CD48/CD58 lymphocyte costimulatory pathways in the development of mercury chloride (HgCl2)-induced autoimmune disease in mice, which is believed to be mediated by T helper (Th) subset Th2. Inhibition of CD40-CD40-L and CTLA4/CD28-B7s
The requirement for proteasome activity class I major histocompatibility complex antigen presentation is dictated by the length of preprocessed antigen.: J Exp Med. 1996 Apr 1;183(4):1545-52. Unique Identifier : AIDSLINE MED/96261656; Yang B; Hahn YS; Hahn CS; Braciale TJ; Beirne B. Carter Center for Immunology Research, University of; Virginia Health Sciences Center, Charlottesville 22908, USA.; Accumulating evidence has implicated the proteasome in the processing of protein along the major histocompatibility complex (MHC) class I presentation pathway. The availability of potent proteasome inhibitors provides an opportunity to examine the role of proteasome function in antigen presentation by MHC class I mole
Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes.: J Exp Med. 1996 Apr 1;183(4):1561-7. Unique Identifier : AIDSLINE MED/96261658; Tian J; Atkinson MA; Clare-Salzler M; Herschenfeld A; Forsthuber T; Lehmann PV; Laufman DL; Department of Molecular and Medical Pharmacology, University of; California, Los Angeles 90095-1735, USA.; We previously demonstrated that a spontaneous Th1 response against glutamate decarboxylase (GAD65) arises in NOD mice at four weeks in age and subsequently T cell autoimmunity spreads both intramolecularly and intermolecularly. Induction of passive tolerance to GAD65, through inactivation of reactive T cells before th
Infection of human immunodeficiency virus 1 transgenic mice with Toxoplasma gondii stimulates proviral transcription in macrophages in vivo.: J Exp Med. 1996 Apr 1;183(4):1645-55. Unique Identifier : AIDSLINE MED/96261665; Gazzinelli RT; Sher A; Cheever A; Gerstberger S; Martin MA; Dickie P; Immunobiology Section, Laboratory of Parasitic Diseases, National; Institute of Allergy and Infectious Diseases, National Institutes; of Health, Bethesda, Maryland 20892, USA.; Human immunodeficiency virus (HIV) 1 transgenic mice expressing low or undetectable levels of viral mRNA in lymphoid tissue were infected with the intracellular protozoan Toxoplasma gondii. Exposure to this parasite resulted in an increase in HIV-1 transcript in lymph nodes, spleens, and lungs during the acute phase o
T cell receptor usage and fine specificity of human immunodeficiency virus 1-specific cytotoxic T lymphocyte clones: analysis of quasispecies recognition reveals a dominant response directed against a minor in vivo variant.: J Exp Med. 1996 Apr 1;183(4):1669-79. Unique Identifier : AIDSLINE GENBANK/U50073; Kalams SA; Johnson RP; Dynan MJ; Hartman KE; Harrer T; Harrer E; Trocha AK; Blattner WA; Buchbinder SP; Walker BD; AIDS Research Center and Infectious Disease Unit, Massachusetts; General Hospital, Boston, 02114, USA.; Numerous virus-specific, class I-restricted cytotoxic T lymphocyte (CTL) epitopes have been identified, yet little information is available regarding the specificity of the CTL response in persons of the same human histocompatibility leukocyte antigen (HLA) type. In this study, the human immunodeficiency virus (HIV) 1
Distinct T cell receptor signaling requirements for perforin- or FasL-mediated cytotoxicity.: J Exp Med. 1996 Apr 1;183(4):1697-706. Unique Identifier : AIDSLINE MED/96261670; Esser MT; Krishnamurthy B; Braciale VL; Department of Microbiology, University of Virginia, Health; Sciences Center, Charlottesville 22908, USA.; A diverse array of signals are generated in a cytotoxic T lymphocyte (CTL) after the T cell receptor (TCR) engages the class I major histocompatibility complex (MHC) peptide complex. These signals result in a multitude of CTL effector functions, including cellular cytotoxicity, cell surface receptor expression, and cy
Requirement for CD8+ T cells in the development of airway hyperresponsiveness in a marine model of airway sensitization.: J Exp Med. 1996 Apr 1;183(4):1719-29. Unique Identifier : AIDSLINE MED/96261672; Hamelmann E; Oshiba A; Paluh J; Bradley K; Loader J; Potter TA; Larsen GL; Gelfand EW; Division of Basic Sciences, Department of Pediatrics, University; of Colorado Health Science Center, Denver 80206, USA.; To study the role of CD8+ T cells in allergic sensitization, we examined the effects of in vivo depletion of CD8+ T cells prior to sensitization on IgE production, immediate type cutaneous hypersensitivity and development of altered airway responsiveness. BALB/c mice were thymectomized and treated with anti-CD8 antibo
Circumventing genetic restriction of protection against malaria with multigene DNA immunization: CD8+ cell-, interferon gamma-, and nitric oxide-dependent immunity.: J Exp Med. 1996 Apr 1;183(4):1739-46. Unique Identifier : AIDSLINE MED/96261674; Doolan DL; Sedegah M; Hedstrom RC; Hobart P; Charoenvit Y; Hoffman SL; Malaria Program, Naval Medical Research Institute, Bethesda,; Maryland 20889-5607, USA.; Despite efforts to develop vaccines that protect against malaria by inducing CD8+ T cells that kill infected hepatocytes, no subunit vaccine has been shown to circumvent the genetic restriction inherent in this approach, and little is known about the interaction of subunit vaccine-induced immune effectors and infected
Patr-A and B, the orthologues of HLA-A and B, present hepatitis C virus epitopes to CD8+ cytotoxic T cells from two chronically infected chimpanzees.: J Exp Med. 1996 Apr 1;183(4):1761-75. Unique Identifier : AIDSLINE GENBANK/L47299; Kowalski H; Erickson AL; Cooper S; Domena JD; Parham P; Walker CM; Department of Structural Biology, Stanford University, California; 94305, USA.; Common chimpanzees (Pan troglodytes) infected with hepatitis C virus (HCV) show a disease progression similar to that observed for human patients. Although most infected animals develop a chronic hepatitis, virus persistence is associated with an ongoing immune response, for which the beneficial or detrimental effects
The interaction of macrophage and non-macrophage tropic isolates of HIV-1 with thymic and tonsillar dendritic cells in vitro.: J Exp Med. 1996 Apr 1;183(4):1851-6. Unique Identifier : AIDSLINE MED/96261684; Cameron PU; Lowe MG; Sotzik F; Coughlan AF; Crowe SM; Shortman K; AIDS Pathogenesis Unit, Macfarlane Burnet Centre for Medical; Research, Fairfield Hospital, Victoria, Australia.; Dendritic cells isolated from thymus and tonsil were tested for susceptibility to HIV-1 strains that are tropic for macrophages or for T cell lines. DCs were purified by cell sorting and before infection expressed high levels of CD4 and HLA-DR and lacked markers for T, B, NK cells, or macrophages. Viral entry and reve
Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells.: J Exp Med. 1996 Apr 1;183(4):1879-92. Unique Identifier : AIDSLINE MED/96261687; Zhou T; Cheng J; Yang P; Wang Z; Liu C; Su X; Bluethmann H; Mountz JD; Department of Medicine, Division of Clinical Immunology and; Rheumatology, University of Alabama at Birmingham, USA.; The Nur77/Nurr1 family of DNA binding proteins has been reported to be required for the signal transduction of CD3/T cell receptor (TCR)-mediated apoptosis in T cell hybridomas. To determine the role of this family of DNA-binding proteins in thymic clonal deletion, transgenic (Tg) mice bearing a dominant negative muta
gamma/delta T cell-deficient mice have impaired mucosal immunoglobulin A responses.: J Exp Med. 1996 Apr 1;183(4):1929-35. Unique Identifier : AIDSLINE MED/96261692; Fujihashi K; McGhee JR; Kweon MN; Cooper MD; Tonegawa S; Takahashi I; Hiroi T; Mestecky J; Kiyono H; Department of Oral Biology, University of Alabama at Birmingham,; Medical Center 35294, USA.; Mucosal tissues of mice are enriched in T cells that express the gamma/delta T cell receptor. Since the function of these cells remains unclear, we have compared mucosal immune responses in gamma/delta T cell receptor-deficient (TCRdelta-/-) mice versus control mice of the same genetic background. The frequency of int
On fighting versus accepting stressful circumstances: primary and secondary control among HIV-positive men in prison.: J Pers Soc Psychol. 1996 Jun;70(6):1307-17. Unique Identifier : AIDSLINE MED/96252506; Thompson SC; Collins MA; Newcomb MD; Hunt W; Department of Psychology, Pomona College, Claremont Graduate; School, California 91711, USA.; The primacy of primary control over secondary control and ethnic differences in control processes were tested in HIV-positive male state prison inmates. They rated their perceptions of control and psychological distress at an initial interview (N = 95) and 3 months later (N = 78). Regression analyses revealed that pri
The role of the consultation-liaison nurse. Caring for patients with AIDS dementia complex.: J Psychosoc Nurs Ment Health Serv. 1995 Dec;33(12):31-4. Unique Identifier : AIDSLINE MED/96255666; Price N; University of Rochester Medical Center, New York 14642-8404, USA.
Preparation and structure-activity relationship of novel P1/P1'-substituted cyclic urea-based human immunodeficiency virus type-1 protease inhibitors.: J Med Chem. 1996 May 24;39(11):2156-69. Unique Identifier : AIDSLINE MED/96238088; Nugiel DA; Jacobs K; Kaltenbach RF; Worley T; Patel M; Meyer DT; Jadhav PK; De Lucca GV; Smyser TE; Klabe RM; Bacheler LT; Rayner MM; Seitz SP; Dupont Merck Pharmaceutical Company, Wilmington, Delaware; 19880-0500, USA.; A series of novel P1/P1 -substituted cyclic urea-based HIV-1 protease inhibitors was prepared. Three different synthetic schemes were used to assemble these compounds. The first approach uses amino acid-based starting materials and was originally used to prepare DMP
From the Food and Drug Administration.: JAMA. 1996 Jul 3;276(1):14. Unique Identifier : AIDSLINE MED/96298965; Nightingale SL; Office of Health Affairs, FDA, Rockland, MD 20857, USA.
Professional boxing, bleeding, and HIV testing [letter]: JAMA. 1996 Jul 17;276(3):193. Unique Identifier : AIDSLINE MED/96290584; Drotman DP
Intestinal intraepithelial lymphocytes: identification of an inhibitory subpopulation.: J Surg Res. 1996 Jun;63(1):123-7. Unique Identifier : AIDSLINE MED/96260055; Teitelbaum DH; Reyes BC; Merion RM; Mosely Lee; Department of Surgery, University of Michigan Medical Center, Ann; Arbor 48109, USA.; The intestinal intraepithelial lymphocytes (iIEL) may play a critical role in preventing overwhelming sensitization to foreign luminal antigens. The purpose of this experiment was to identify the subpopulation of the iIEL responsible for this inhibitory action. One-way mixed lymphocyte cultures (MLC) were performed wi
Melatonin administration attenuates depressed immune functions trauma-hemorrhage.: J Surg Res. 1996 Jun;63(1):256-62. Unique Identifier : AIDSLINE MED/96260078; Wichmann MW; Zellweger R; DeMaso; Ayala A; Chaudry IH; Shock and Trauma Research Laboratories, Department of Surgery,; Michigan State University, East Lansing 48824-1315.; The pineal hormone melatonin has been used in clinical trials in patients suffering from AIDS and also as an adjuvant for cancer therapy. Although melatonin has been reported to have beneficial effects in some animal models of immune dysfunction, it remains unknown whether this hormone has any salutary effects on immu
Cardia allograft unresponsiveness using a posttransplant strategy : characterization of the graft infiltrate.: J Surg Res. 1996 Jun;63(1):86-92. Unique Identifier : AIDSLINE MED/96260049; Krieger NR; Quezada VR; Huie P; Holm B; Sibley RK; Dafoe DC; Alfrey EJ; Department of Surgery, Stanford University, California 94305,; USA.; We evaluated a combined posttransplant strategy using antilymphocyte serum (ALS) at time of engraftment followed by low dose total lymphoid irradiation (TLI) and donor bone marrow cell (BMC) inoculation administered either intrathymically (IT) or intravenously (IV) in the vigorously rejecting strain combination DA int
Association of 6q deletions with AIDS-related diffuse large cell lymphoma.: Leukemia. 1996 Jun;10(6):1051-3. Unique Identifier : AIDSLINE MED/96266517; Pastore C; Carbone A; Gloghini A; Volpe G; Saglio G; Gaidano G; Dipartimento di Scienze Biomediche e Oncologia Umana, Universita; di Torino, Ospedale San Luigi, Italy.; Deletions of chromosome 6 at band q27 represent the site of a putative novel tumor suppressor gene in non-Hodgkin s lymphomas (NHL) of the immunocompetent host. Although several genetic lesions have been identified in AIDS-related NHL (AIDS-NHL), the involvement of 6q27 loss has not been investigated in this NHL categ
[The pattern of AIDS-indicative diseases in adults and adolescents in Spain, 1988-1993]: Med Clin (Barc). 1996 Feb 24;106(7):246-50. Unique Identifier : AIDSLINE MED/96274649; Castilla J; Gutierrez A; Ramos B; Camarero M; Burgoa M; Noguer I; Centro Nacional de Epidemiologia, Instituto de Salud Carlos III,; Madrid.; BACKGROUND: The pattern of AIDS-defining diseases in adults and adolescents in Spain from 1988-1993 has been described. METHODS: Twenty-two thousand two hundred thirty-nine cases (CDC, 1987) diagnosed in patients over the age of 12 years from 1988 to 1993 were taken from the Nationa
[Screening for HIV infection in prisons (letter)]: Med Clin (Barc). 1996 Feb 24;106(7):277-8. Unique Identifier : AIDSLINE MED/96274657; Marco A; Guerrero R; Mercade E; Ballester J
[Reduced transmission of HIV in several African countries]: Lakartidningen. 1996 May 15;93(20):1976-7. Unique Identifier : AIDSLINE MED/96257001; Christenson B; Lundbergh P; Karolinska sjukhuset, Stockholm.
Age as a predictor of progression in HIV infection [comment]: Lancet. 1996 Jun 8;347(9015):1569-70. Unique Identifier : AIDSLINE MED/96240930; Volberding PA; University of California, San Francisco School of Medicine,; 94110, USA.
Importance of age at infection with HIV-1 for survival and development of AIDS in UK haemophilia population. UK Haemophilia Centre Directors' Organisation [see comments]: Lancet. 1996 Jun 8;347(9015):1573-9. Unique Identifier : AIDSLINE MED/96240934; Darby SC; Ewart DW; Giangrande PL; Spooner RJ; Rizza CR; Cancer Epidemiology Unit, Oxford University, Radcliffe Infirmary,; UK.; BACKGROUND: Greater age at infection with HIV-1 is known to be associated with shorter time to development of AIDS, but the size of the differences between people infected in infancy and those infected in old age has not been examined in a single large population of patients with death as an endpoint. We, therefore, i
An uneasy relationship: the tensions between medicine and the media.: Lancet. 1996 Jun 8;347(9015):1600-3. Unique Identifier : AIDSLINE MED/96240942; Nelkin D; Department of Sociology, New York University, NY 10003, USA.; The enduring tensions between medicine and the media are largely due to the different perspectives of biomedical scientists and journalists, as this final essay in the series on medicine and the media underscores. These tensions arise because of perceived differences in defining science news, conflicts over styles of
Surprise twist to Canada's tainted-blood inquiry [news]: Lancet. 1996 Jun 8;347(9015):1617. Unique Identifier : AIDSLINE MED/96240950; Kondro W
Implications of genetic variability in HIV for epidemiology and public health.: Lancet. 1996 Jun 29;347(9018):1778-9. Unique Identifier : AIDSLINE MED/96281723; Anderson RM; Schwartlander B; McCutchan F; Hu D; Centre for the Epidemiology of Infectious Disease, University of; Oxford, UK.
Lethal infection by a previously unrecognised metazoan parasite.: Lancet. 1996 Jun 29;347(9018):1797-801. Unique Identifier : AIDSLINE MED/96281732; Santamaria-Fries M; Fajardo LF; Sogin ML; Olson PD; Relman DA; Department of Pathology, Kaiser-Permanente Medical Center, Santa; Clara, CA, USA.; BACKGROUND: New microbial pathogens or variant clinical manifestations of known organisms may be first found in immunodeficient patients. An HIV-infected man developed a rapidly-enlarging abdominal mass, suggestive of a neoplasm, that subsequently invaded his liver and caused death. Initial studies showed unusual tiss
Timing of fetal membrane rupture predicts HIV risk [news]: Lancet. 1996 Jun 29;347(9018):1821. Unique Identifier : AIDSLINE MED/96304381; McCarthy M
Involuntarily detained HIV-infected patients in Sweden: reasons for referral and psychiatric diagnoses.: Med Law. 1995;14(7-8):491-500. Unique Identifier : AIDSLINE MED/96251836; Alexius B; Heilbrunn U; Beck B; Wistedt B; Karolinska Institute, Department of Psychiatry, St Goran's; Hospital, Stockholm, Sweden.; The Swedish Communicable Diseases Act permits the isolation of an HIV-infected person if there is risk of disease transmission. The purpose is for the patient to receive the support needed to alter his or her attitude and behaviour so that the isolation can be terminated. This study describes the reasons for referral
HIV infection in Malaysia: a report of cases seen at the University Hospital, Kuala Lumpur.: Med J Malaysia. 1995 Dec;50(4):298-301. Unique Identifier : AIDSLINE MED/96224540; Ismail R; Doi S; Naganathna N; Department of Medicine, Faculty of Medicine, University of; Malaya, Kuala, Lumpur.; The spread of HIV infection into Malaysia is estimated to have occurred in the early 1980 s. The first case of AIDS was reported here in 1986. As of March 31, 1994, the numbers have increased to 8049 HIV positive individuals detected in the country. The risk behaviours among thos
The HIV-associated risk behaviour among male drug abusers in Malaysia.: Med J Malaysia. 1995 Dec;50(4):320-5. Unique Identifier : AIDSLINE MED/96224544; Juita G; Osman A; Department of Community Health, Faculty of Medicine, Universiti; Kebangsaan Malaysia, Kuala, Lumpur.; To examine the risk factors of HIV type-I infection among male drug addicts in Malaysia , a case-control study was conducted on inmates, aged 20-40 years, at a drug rehabilitation centre in January, 1994. Stratified random sampling was performed. A total of 87 cases and 261 contro
Age-specific HIV incidence among homosexually active men in Australia.: Med J Aust. 1996 Jun 17;164(12):715-8. Unique Identifier : AIDSLINE MED/96269458; Law MG; Rosenberg PS; McDonald A; Kaldor JM; National Centre in HIV Epidemiology and Clinical Research,; University of New South Wales, Sydney, NSW.; mlaw@nchecr.unsw.edu.au; OBJECTIVE: To estimate age at HIV infection among homosexually active men in Australia . DESIGN: Age-specific back-projection estimates of HIV incidence. METHODS: Monthly counts of AIDS among homosexually active men diagnosed by 30 June 1994 and reported by 31 March 1995 were obt
TFIIH functions in regulating transcriptional elongation by RNA polymerase II in Xenopus oocytes.: Mol Cell Biol. 1996 Jul;16(7):3291-9. Unique Identifier : AIDSLINE MED/96251277; Yankulov KY; Pandes M; McCracken S; Bouchard D; Bentley DL; Amgen Institute, Toronto, Ontario, Canada.; We investigated the role of TFIIH in transcription by RNA polymerase II (pol II) in vivo by microinjection of antibodies against this factor into Xenopus oocytes. Five different antibodies directed against four subunits of TFIIH were tested for effects on transcription of coinjected human immunodeficiency virus type 2
Requirements for interleukin 2 promoter transactivation by the Tax protein of human T-cell leukemia virus type 1.: Mol Cell Biol. 1996 Jul;16(7):3567-75. Unique Identifier : AIDSLINE MED/96251306; Curtiss VE; Smilde R; McGuire KL; Department of Biology, San Diego State University, California; 92182-4614, USA.; The Tax protein of human T-cell leukemia virus type 1 (HTLV-1) upregulates the expression of several cellular genes by activating members of both the NF-kappaB and bZIP families of transcription factors. Recent studies demonstrate that the CD28 response element (CD28RE) of the interleukin 2 (
Changes in sexual behavior and a decline in HIV infection among young men in Thailand [see comments]: N Engl J Med. 1996 Aug 1;335(5):297-303. Unique Identifier : AIDSLINE MED/96283145; Nelson KE; Celentano DD; Eiumtrakol S; Hoover DR; Beyrer C; Suprasert S; Kuntolbutra S; Khamboonruang C; Department of Epidemiology, School of Hygiene and Public Health,; Johns Hopkins University, Baltimore, MD 21205, USA.; BACKGROUND: In Thailand the epidemic of human immunodeficiency virus (HIV) infection is of recent origin. Because of the high seroprevalence of HIV among sex workers, the Ministry of Public Health began a program in 1990 and 1991 to promote the use of condoms during commercial se
The march of AIDS through Asia [editorial; comment]: N Engl J Med. 1996 Aug 1;335(5):343-5. Unique Identifier : AIDSLINE MED/96283154; Weniger BG; Brown T
Physicians' experience and survival in patients with AIDS [letter; comment]: N Engl J Med. 1996 Aug 1;335(5):349; discussion 350-1. Unique Identifier : AIDSLINE MED/96283157; Coker RJ; Poznansky MC
Physicians' experience and survival in patients with AIDS [letter; comment]: N Engl J Med. 1996 Aug 1;335(5):349-50; discussion 350-1. Unique Identifier : AIDSLINE MED/96283158; Bach PB
Physicians' experience and survival in patients with AIDS [letter; comment]: N Engl J Med. 1996 Aug 1;335(5):350; discussion 351. Unique Identifier : AIDSLINE MED/96283159; Guerra-Romero L; Parras Vazquez F
Physicians' experience and survival in patients with AIDS [letter; comment]: N Engl J Med. 1996 Aug 1;335(5):350; discussion 350-1. Unique Identifier : AIDSLINE MED/96283160; Macher AM; Goosby EP
Human herpesvirus 8 and interstitial pneumonitis in an HIV-negative patient [letter]: N Engl J Med. 1996 Aug 1;335(5):351-2. Unique Identifier : AIDSLINE MED/96283161; Luppi M; Torelli G
[Progressive paralysis. A case report]: Minerva Med. 1996 Mar;87(3):113-5. Unique Identifier : AIDSLINE MED/96269489; Trotta M; Sterrantino G; Meli M; Dionisio D; Regoli G; Leoncini F; Unita Operativa Malattie Infettive Azienda USL 10, Antella; Azienda Ospedaliera Careggi, Firenze.; STUDY OBJECTIVE. A fairly uncommon case of neurosyphilis is reported in a not immunocompromised patient. CASE REPORT. A case of general paresis in a 40 year-old male with the recent onset of mania is described. Psychiatric anamnesis was negative. Neurologic examination was negative. Laboratory tests were performed and
Selective activation of the proto-oncogene c-jun promoter by the transforming protein v-Rel.: Oncogene. 1996 May 16;12(10):2193-202. Unique Identifier : AIDSLINE MED/96218669; Fujii M; Minamino T; Nomura M; Miyamoto KI; Tanaka J; Seiki M; Department of Molecular Virology and Oncology, Cancer Research; Institute, Kanazawa University, Japan.; The transcription factor v-Rel is a transforming protein of the reticuloendotheliosis virus. We found that v-Rel activates the promoter of the proto-oncogene c-jun. Two elements in the c-jun promoter were required for the activation by v-Rel. One was a kB-site (v-Rel binding site), and the other was a c-jun promoter r
Opportunistic fungal infections in patients with HIV disease: combating cryptococcosis and histoplasmosis.: Postgrad Med. 1996 Jun;99(6):209-16. Unique Identifier : AIDSLINE MED/96281719; Kirchner JT; Department of Family and Community Medicine, Lancaster General; Hospital, PA 17603, USA.; Both cryptococcosis and histoplasmosis are life-threatening diseases in patients with advanced HIV infection. Cryptococcal disease in patients with AIDS is usually a systemic illness with an insidious onset of meningoencephalitis. Development of potent oral antifungal agents has simplified therapy, although patients w
[Recurrent bilateral uveitis associated with HTLV 1 infection (letter)]: Presse Med. 1996 Apr 13;25(13):643. Unique Identifier : AIDSLINE MED/96263475; Clement MA; Fresard A; Granier-Chevassus C; Lucht F
Screening, health promotion, and prevention in men.: Prim Care. 1995 Dec;22(4):679-95. Unique Identifier : AIDSLINE MED/96245667; Horst T; Meyer B; Taplin S; Group Health Cooperative of Puget Sound, University Medical; Center, Seattle, WA 98105-6099, USA.; The authors emphasize screening for prostate and testicular cancer, HIV, and drug/alcohol abuse. Factors such as firearm safety, violence in the home, smoking, and exercise are also discussed.
Relation between perceived vulnerability to HIV and precautionary sexual behavior.: Psychol Bull. 1996 May;119(3):390-409. Unique Identifier : AIDSLINE MED/96220562; Gerrard M; Gibbons FX; Bushman BJ; Department of Psychology, Iowa State University, Ames 50011-3180,; USA. mgerrard@iastate.edu; Although virtually all major theories of health-protective behavior assume that precautionary behavior is related to perceived vulnerability, the applicability of this assumption to human immunodeficiency virus (HIV) preventive behavior has recently been called into question. This article uses qualitative and quantita
Tuberculosis mortality associated with AIDS and drug or alcohol abuse: analysis of multiple cause-of-death data.: Public Health. 1996 May;110(3):185-9. Unique Identifier : AIDSLINE MED/96268017; White MC; Portillo CJ; School of Nursing, University of California, San Francisco, USA.; The resurgence in tuberculosis morbidity in the mid-1980s has increased interest in tuberculosis mortality. We examined mortality in the United States , from tuberculosis in 1990, using multiple cause-of-death data to describe the impact of AIDS and substance abuse, defined as drug or a
Proton MR spectroscopy of the basal ganglia in healthy children and children with AIDS.: Radiology. 1996 May;199(2):423-8. Unique Identifier : AIDSLINE MED/96202778; Lu D; Pavlakis SG; Frank Y; Bakshi S; Pahwa S; Gould RJ; Sison C; Hsu C; Lesser M; Hoberman M; Barnett T; Hyman RA; Department of Radiology, North Shore University Hospital,; Manhasset, NY 11030, USA.; PURPOSE: To evaluate proton magnetic resonance (MR) spectroscopy in children with the acquired immunodeficiency syndrome (AIDS) and to establish an age-dependent spectroscopic database of the normal basal ganglia in children. MATERIALS AND METHODS: Eighteen healthy children and 45 children with AIDS underwent both bra
[Clarithromycin combined with pyrimethamine in cerebral toxoplasmosis--a a report of 2 cases]: Rev Soc Bras Med Trop. 1995 Oct-Dec;28(4):409-13. Unique Identifier : AIDSLINE MED/96273721; Dalston MO; Tavares W; Bazin AR; Hahn MD; dos Santos AA; Pimentel T; Mello JN; Disciplina de Doencas Infecciosas e Parasitarias, Hospital; Universitario Antonio Pedro, Faculdade de Medicina, Universidade; Federal Fluminense, Niteroi, RJ.; The authors report the use and the outcome of claritromycin associated with pyrimethamine in the treatment of toxoplasma encephalites in two patients with AIDS. Both patients had the diagnosis stablished on clinical grounds, positive sorology (IgG) for toxoplasmosis and computed-tomographic (CT) scan of the brain show
Pathogenesis of cytomegalovirus pneumonia in immunocompromised hosts.: Semin Respir Infect. 1995 Dec;10(4):199-208. Unique Identifier : AIDSLINE MED/96262963; Riddell SR; Department of Medicine, Fred Hutchinson Cancer Research Center,; University of Washington, Seattle 98104, USA.; Cytomegalovirus ( CMV ) is capable of establishing persistent or latent infection after primary infections and reactivation in immunocompromised hosts. The understanding of the nature of this latency is incomplete. The acquisition of CMV-specific immune responses
Cytomegalovirus pneumonia: presentation, diagnosis, and treatment.: Semin Respir Infect. 1995 Dec;10(4):209-15. Unique Identifier : AIDSLINE MED/96262964; Ljungman P; Department of Medicine, Huddinge University Hospital, Sweden.; Cytomegalovirus ( CMV ) pneumonia has been one of the most important opportunistic infections in the immunocompromised host. The disease is particularly severe in allogeneic bone marrow transplant recipients, with an almost 100% mortality rate in untreated patient
Childhood viruses as a cause of pneumonia in adults.: Semin Respir Infect. 1995 Dec;10(4):232-43. Unique Identifier : AIDSLINE MED/96262967; Yang E; Rubin BK; Department of Medicine, St Louis University School of Medicine,; MO 63104-1095, USA.; Respiratory viruses are a common cause of morbidity in childhood. Except in the child with immunodeficiency, the common respiratory viruses rarely pose a serious threat to life. Because infection with most of these viruses in childhood is nearly universal and usually bestows partial immunity, the childhood respiratory
Human herpesvirus 6 as a possible cause of pneumonia.: Semin Respir Infect. 1995 Dec;10(4):254-8. Unique Identifier : AIDSLINE MED/96262969; Cone RW; Department of Medicine, University Hospital, Zurich, Switzerland.; Case reports and limited retrospective studies have established that human herpesvirus 6 (HHV-6) can be found in lung tissues from patients with pneumonia. Most cases of HHV-6-associated pneumonia involve immunocompromised patients, especially those who have received a bone marrow transplant or who have been infected
Bayesian imputation of predictive values when covariate information is available and gold standard diagnosis is unavailable.: Stat Med. 1996 Mar 15;15(5):463-76. Unique Identifier : AIDSLINE MED/96250042; Epstein LD; Munoz A; He D; Department of Biostatistics, Johns Hopkins School of Hygiene and; Public Health, Baltimore, MD 21205, USA.; We suggest a conceptually simple Bayesian approach to inferences about the conditional probability of a specimen being infection-free given the outcome of a diagnostic test and covariate information. The approach assumes that the infection state of a specimen is not observable but uses the outcomes of a second test in
Assessment of HIV testing rates among HIV infected individuals using incidence data on HIV and AIDS diagnoses.: Stat Med. 1996 Mar 15;15(5):497-511. Unique Identifier : AIDSLINE MED/96250044; Marschner IC; Department of Biostatistics, Harvard School of Public Health,; Boston, MA 02115, USA.; This paper considers estimation of the rate HIV diagnosis in a population of HIV positive individuals. A number of previous papers have studied the situation where time of first positive HIV test is available for AIDS cases, and possibly for individuals who have not yet developed AIDS. In this context, AIDS diagnoses
Historical HIV incidence modelling in regional subgroups: use of flexible discrete models with penalized splines based on prior curves.: Stat Med. 1996 Mar 15;15(5):513-25. Unique Identifier : AIDSLINE MED/96250045; Greenland S; Department of Epidemiology, UCLA School of Public Health; 90095-1772, USA.; This paper presents an approach to back-projection (back-calculation) of human immunodeficiency virus (HIV) person-year infection rates in regional subgroups based on combining a log-linear model for subgroup differences with a penalized spline model for trends. The penalized spline approach allows flexible trend esti
Hearing aid systems in undeveloped, developed and industrialized countries.: Scand Audiol Suppl. 1996;42:35-9. Unique Identifier : AIDSLINE MED/96253933; Arslan E; Genovese E; Department of Audiology and Phoniatrics, University of Padova,; Italy.; The problems related with the hearing loss prevalence and deafness rehabilitation in Developing (D) countries are so complex that only basic needs and some suggestions are discussed in this paper. In fact for D countries the main demographic and social indi reveal the enormous gravity of the health situation and so th
Adjuvant properties of montanide CSA 720 with a recombinant HIV P17 gag protein and synthetic peptide antigens.: Scand J Immunol. 1996 Apr;43(4):431-8. Unique Identifier : AIDSLINE MED/96249510; Kirkley JE; Goldstein AL; Naylor PH; Department of Biology, Knox College, Galesburg, IL 61401, USA.; The adjuvant properties of Montanide CSA 720 were assessed in a comparison with alum. BALB/c mice were immunized with recombinant HIV-1 gag protein p17 administered in either of the two adjuvants. The serum antibody response to p17 with Montanide CSA 720 appeared faster and reached a higher titre than with alum. The s
Four dually resistant human cytomegalovirus strains from AIDS patients: single mutations in UL97 and UL54 open reading frames are responsible for ganciclovir- and foscarnet-specific resistance, respectively.: Scand J Infect Dis Suppl. 1995;99:103-4. Unique Identifier : AIDSLINE MED/96244198; Baldanti F; Sarasini A; Silini E; Barbi M; Lazzarin A; Biron KK; Gerna G; Viral Diagnostic Service IRCCS Policlinico S. Matteo, Pavia,; Italy.; Four human cytomegalovirus strains with double resistance to both ganciclovir and foscarnet were recovered from acquired immunodeficiency syndrome (AIDS) patients. The four isolates were genetically unrelated and each of them consisted of a single viral population. In addition, for
The role of CD8+, CD57+ cells in human cytomegalovirus and other viral infections.: Scand J Infect Dis Suppl. 1995;99:69-77. Unique Identifier : AIDSLINE MED/96244190; Wang EC; Borysiewicz LK; Department of Medicine, University of Wales College of Medicine,; Heath Park, Cardiff, UK.; Peripheral blood lymphocytes expressing CD8 and CD57 determinants are a small (1-15%) subset in healthy humans. CD8+, CD57+ peripheral blood lymphocytes may be divided by the level of CD8 expression, into CD8+high (CD57+) T-cells and CD8+low (CD57+) natural killer (NK) cells. CD8+high (CD57+) T-cell numbers are increa
Deletion mutants in human cytomegalovirus glycoprotein US9 are impaired in cell-cell transmission and in altering tight junctions of polarized human retinal pigment epithelial cells.: Scand J Infect Dis Suppl. 1995;99:82-7. Unique Identifier : AIDSLINE MED/96244192; Pereira L; Maidji E; Tugizov S; Jones T; Department of Stomatology, School of Dentistry, University of; California at San Francisco, USA.; Retinal cytomegalovirus ( CMV ) disease is one of the major manifestations of viral pathogenesis in immunosuppressed patients with the acquired immunodeficiency syndrome (AIDS). CMV infection of the retina causes directional de
Diagnosis of cytomegalovirus infection of the nervous system in AIDS by polymerase chain reaction analysis of cerebrospinal fluid.: Scand J Infect Dis Suppl. 1995;99:92-4. Unique Identifier : AIDSLINE MED/96244194; Cinque P; Vago L; Terreni MR; Brytting M; Marenzi R; Castagna A; Lazzarin A; Linde A; Department of Infectious Disease, San Raffaele Scientific; Institute, Milan, Italy.; To evaluate the diagnostic relevance and the clinical impact of the cerebrospinal fluid (CSF) polymerase chain reaction (PCR) for cytomegalovirus ( CMV ) DNA in the diagnosis of CMV infection of the central nervous system (CNS)
CMV PCR in leucocytes as an early marker for the development of CMV disease in AIDS patients.: Scand J Infect Dis Suppl. 1995;99:94-5. Unique Identifier : AIDSLINE MED/96244195; Quarner H; Grutzmeier S; Lewensohn-Fuchs I; Hejdeman B; Sandstrom E; Ehrnst A; Department of Dermatology & Venereal Diseases, South Hospital,; Sweden.; The relationship between cytomegalovirus ( CMV ) DNA in leucocytes and CMV disease in AIDS patients was sought. In 195 HIV-1 infected, mostly AIDS patients, CMV nPCR was performed in 477 peripheral EDTA blood samples which were
Update (1995) on clinical trials of antiviral therapy and prophylaxis for AIDS-related cytomegalovirus disease.: Scand J Infect Dis Suppl. 1995;99:96-9. Unique Identifier : AIDSLINE MED/96244196; Jacobson MA; University of California at San Francisco, San Francisco General; Hospital, USA.; An overview of the current state of antiviral therapy and prophylaxis for opportunistic cytomegalovirus ( CMV ) disease in 1995 is provided, focusing primarily on therapeutic trials for AIDS-related CMV retinitis. Retinitis is
Structure of the amino-terminal core domain of the HIV-1 capsid protein.: Science. 1996 Jul 12;273(5272):231-5. Unique Identifier : AIDSLINE MED/96279637; Gitti RK; Lee BM; Walker J; Summers MF; Yoo S; Sundquist WI; Howard Hughes Medical Institute and Department of Chemistry and; Biochemistry, University of Maryland Baltimore County, Baltimore,; MD 21228, USA.; The three-dimensional structure of the amino-terminal core domain (residues 1 through 151) of the human immunodeficiency virus-type 1 (HIV-1) capsid protein has been solved by multidimensional heteronuclear magnetic resonance spectroscopy. The structure is unlike those of previously characterized viral coat proteins a
A group design for HIV-negative gay men.: Soc Work. 1996 Jul;41(4):407-15. Unique Identifier : AIDSLINE MED/96267612; Koetting ME; Medical and Health Research Association, New York, USA.; The social work and psychotherapeutic literature is replete with information on the psychosocial needs of HIV-positive gay men and gay men living with AIDS. However, scant information focuses on an often-overlooked population: HIV-negative gay men. This article examines the development of a group design that addresses
Determinants of red cell, platelet, plasma, and cryoprecipitate transfusions during coronary artery bypass graft surgery: the Collaborative Hospital Transfusion Study.: Transfusion. 1996 Jun;36(6):521-32. Unique Identifier : AIDSLINE MED/96269511; Surgenor DM; Churchill WH; Wallace EL; Rizzo RJ; Chapman RH; McGurk S; Bertholf MF; Goodnough LT; Kao KJ; Koerner TA; Olson JD; Woodson RD; Center for Blood Research, Harvard Medical School, Boston,; Massachusetts, USA.; BACKGROUND: Very little is known about the determinants of blood transfusions in patients undergoing coronary artery bypass graft surgery. STUDY DESIGN AND METHODS: To identify factors that influenced the transfusion of red cells, platelets, plasma, and cryoprecipitate, statistical methods were used to study 2476 cons
Photosensitized inactivation of Plasmodium falciparum in human red cells by phthalocyanines.: Transfusion. 1996 Jun;36(6):543-6. Unique Identifier : AIDSLINE MED/96269514; Lustigman S; Ben-Hur E; Lindsley F. Kimball Research Institute, New York Blood Center,; New York, USA.; BACKGROUND: Photodynamic treatment of red cell concentrate with phthalocyanines and red light inactivates lipid-enveloped viruses such as vesicular stomatitis virus and human immunodeficiency virus. This procedure is evaluated for its ability to enhance the viral safety of red cell concentrate for transfusion. It is o
Effect of blood donation on the establishment of normal ranges of lymphocyte subsets.: Transfusion. 1996 Jun;36(6):559-66. Unique Identifier : AIDSLINE MED/96269517; Bryant JA; Wylie BR; Yuan FF; Ribeiro A; Thomson AR; Cooley MA; Fletcher A; New South Wales Red Cross Blood Transfusion Service, Sydney,; Australia.; BACKGROUND: Absolute counts of CD4+ T-lymphocytes are used in the management of patients with human immunodeficiency virus infection. Low absolute counts of CD3+CD4+ cells have also been observed in healthy people--a phenomenon called idiopathic CD4 lymphocytopenia. It is common practice for normal ranges for lymphocy
Inhibition of feline immunodeficiency virus infection in vitro by envelope glycoprotein synthetic peptides.: Virology. 1996 Jun 15;220(2):274-84. Unique Identifier : AIDSLINE MED/96251924; Lombardi S; Massi C; Indino E; La Rosa C; Mazzetti P; Falcone ML; Rovero P; Fissi A; Pieroni O; Bandecchi P; Esposito F; Tozzini F; Bendinelli M; Garzelli C; Department of Biomedicine, University of Pisa, Italy.; Sixty-six 20- to 23-amino-acid synthetic peptides, partially overlapping by 10-12 amino acids, spanning the entire sequence of the envelope SU and TM glycoproteins of the Petaluma isolate of FIV, have been used to investigate the Env domains involved in viral infection. Peptides 5 to 7, spanning amino acids 225E-P264
Mutations within the primer binding site of the human immunodeficiency virus type 1 define sequence requirements essential for reverse transcription.: Virology. 1996 Jun 15;220(2):290-8. Unique Identifier : AIDSLINE MED/96251926; Wakefield JK; Morrow CD; Department of Microbiology, University of Alabama at Birmingham; 35294, USA.; The primer binding site (PBS) is involved in two stages during the reverse transcription of the retroviral RNA genome. In the early stage, the PBS provides complementary sequences through which tRNA(Lys,3) binds the viral RNA genome to initiate minus-strand DNA synthesis; in the later stages, complementarity between t
CD40/CD40L interactions and cytokines regulate HIV replication in B cells in vitro.: Virology. 1996 Jun 15;220(2):309-19. Unique Identifier : AIDSLINE MED/96251928; Gras G; Legendre C; Krzysiek R; Dormont D; Galanaud P; Richard Y; Service de Neurovirologie, CEA/CRSSA, Institut Paris-Sud sur les; Cytokines, Fontenay aux Roses, France.; Using our in vitro model of normal B cell infection, we investigated whether cellular interactions and/or cytokines directing the B cell response also regulate HIV replication. Phorbol esters and CD40 Ab plus IL4, added prior to infection, substantially increased subsequent viral replication. Postinfection, IL2 with o
The effect of simian immunodeficiency virus infection in vitro and in vivo on the cytokine production of isolated microglia and peripheral macrophages from rhesus monkey.: Virology. 1996 Jun 15;220(2):320-9. Unique Identifier : AIDSLINE MED/96251929; Sopper S; Demuth M; Stahl-Hennig C; Hunsmann G; Plesker R; Coulibaly C; Czub S; Ceska M; Koutsilieri E; Riederer P; Brinkmann R; Katz M; ter Meulen V; Institut fur Virologie und Immunbiologie, Universitat; Wurzburg, Germany.; Microglia are the major target for human immunodeficiency virus (HIV) infection within the central nervous system. Because only a few cells are productively infected, it has been suggested that an aberrant cytokine production by this cell population may be an indirect mechanism leading to the development of neurologic
Conservation of a hairpin ribozyme sequence in HIV-1 is required for efficient viral replication.: Virology. 1996 Jun 15;220(2):361-6. Unique Identifier : AIDSLINE MED/96251933; Yamada O; Kraus G; Sargueil B; Yu Q; Burke JM; Wong-Staal F; Department of Medicine, University of California at San Diego, La; Jolla 92093-0665, USA.; We have previously described a hairpin ribozyme that targets a highly conserved sequence in the U5 region of HIV-1. To determine if escape mutations would compromise virus replication, we introduced critical mutations into the ribozyme target site of an infectious molecular clone of HIV-1MN. HIV-1 MNA has a substituti
Long-term protection against HIV-1 infection conferred by tat or rev antisense RNA was affected by the design of the retroviral vector.: Virology. 1996 Jun 15;220(2):377-89. Unique Identifier : AIDSLINE GENBANK/M19921; Peng H; Callison D; Li P; Burrell C; National Centre for HIV Virology Research, Division of Medical; Virology, Institute of Medical and Veterinary Science, Adelaide,; South Australia.; We have constructed a series of retroviral vectors in which the expression of antisense RNA targeted at the full length coding sequence of HIV-1 tat or rev was driven by three different promoters and in the context of double-copy or single-copy vectors. Jurkat cells transduced by these vectors were shown to express th
Functional characterization of the V1V2 region of human immunodeficiency virus type 1.: Virology. 1996 Jun 15;220(2):436-49. Unique Identifier : AIDSLINE +; Palmer C; Balfe P; Fox D; May JC; Frederiksson R; Fenyo EM; McKeating JA; University of Reading, School of Animal & Microbial Sciences,; Whiteknights, United Kingdom.; The level of proviral DNA sequence variation in the V1V2 region was monitored over time in six HIV-1-infected individuals. Substitutional and length variation was observed, where the majority of length changes, ranging from 28 to 49 amino acids, was located within the V1 region. Evidence for convergent evolution in th
Chimeric viruses expressing primary envelope glycoproteins of human immunodeficiency virus type I show increased sensitivity to neutralization by human sera.: Virology. 1996 Jun 15;220(2):450-60. Unique Identifier : AIDSLINE GENBANK/U57794; McKeating JA; Zhang YJ; Arnold C; Frederiksson R; Fenyo EM; Balfe P; University of Reading, School of Animal & Microbial Sciences,; Whiteknights, United Kingdom.; We constructed a number of HXB2 viruses chimeric for the gp 120 glycoprotein derived from a number of viable molecular clones obtained from a primary isolate. Comparative biological characterization of the parental primary viruses with the gp 120.HXB2 chimeras demonstrated identical patterns of cell tropism and cytopa
Mutational analysis of HIV-1 gp160-mediated receptor interference: intracellular complex formation.: Virology. 1996 Jun 15;220(2):461-72. Unique Identifier : AIDSLINE MED/96251942; Martin RA; Nayak DP; Department of Microbiology and Immunology, Jonsson Comprehensive; Cancer Center, UCLA School of Medicine 90024-1747, USA.; Formation of CD4-gp160 intracellular complexes represents an important mechanism leading to the induction of receptor interference. Previous studies have demonstrated that cells coexpressing gp160 and CD4 formed complexes of CD4 and gp160 which became blocked within the endoplasmic reticulum (ER), preventing CD4 from
Membrane anchorage of gp160 is necessary and sufficient to prevent CD4 transport to the cell surface.: Virology. 1996 Jun 15;220(2):473-9. Unique Identifier : AIDSLINE MED/96251943; Martin RA; Nayak DP; Department of Microbiology and Immunology, Jonsson Comprehensive; Cancer Center, School of Medicine, University of California at; Los Angeles 90024-1747, USA.; The HIV envelope glycoprotein gp160 plays a major role in the posttranslational down-regulation of its receptor, CD4. In this report we have analyzed the requirements of both CD4 and gp160 involved in transport block of the gp160-CD4 complex causing the down-regulation of cell surface CD4. Using a transient expression
Nucleo-cytoplasmic redistribution of the HTLV-I Rex protein: alterations by coexpression of the HTLV-I p21x protein.: Virology. 1996 Jun 15;220(2):502-7. Unique Identifier : AIDSLINE MED/96251948; Kubota S; Hatanaka M; Pomerantz RJ; Dorrance H. Hamilton Laboratories, Center for Human; Retrovirology, Department of Medicine, Jefferson Medical College,; Thomas Jefferson University, Philadelphia, Pennsylvania 19107,; USA.; The function of the Rex protein of human T-cell leukemia virus type I (HTLV-I) has been demonstrated to be very similar to the Rev protein of human immunodeficiency virus type 1 (HIV-1). Both of these retroviral regulatory proteins rescue unspliced viral RNAs from the nuclei of infected cells. The Rev protein of HIV-1
Prolonged infection in rhesus macaques with simian immunodeficiency virus (SIVmac239) results in animal-specific and rarely tissue-specific selection of nef variants.: Virology. 1996 Jun 15;220(2):522-9. Unique Identifier : AIDSLINE MED/96251951; Zhu GW; Mukherjee S; Sahni M; Narayan O; Stephens EB; Department of Microbiology, Molecular Genetics, and Immunology,; Marion Merell Dow Laboratory for Viral Pathogenesis, University; of Kansas Medical Center, Kansas City 66160-7240, USA.; We analyzed the sequence of nef genes from different tissues of three rhesus macaques that had been infected with molecularly cloned SIVmac239 for 88 to 92 weeks. Comparison of the predicted amino acid sequences revealed that each macaque had selected out specific amino acid substitutions and that most of this variati
HIV-1 Gag protein associates with F-actin present in microfilaments.: Virology. 1996 Jun 15;220(2):530-4. Unique Identifier : AIDSLINE MED/96251952; Rey O; Canon J; Krogstad P; Department of Pediatrics, School of Medicine, University of; California at Los Angeles 90095, USA.;; Several studies have provided evidence that the cellular cytoskeleton may be involved in the assembly and budding of retroviruses. In fractionation studies of HIV-1-infected CEM cells, the majority of the unprocessed Gag polyprotein cofractionated with the cellular cytoskeleton. In vivo and in vitro analyses of this i
[Effect of mesodiencephalic modulation on peripheral blood immunocompetent cells in viral-bacterial infections]: Vopr Virusol. 1996 Jan-Feb;41(1):16-8. Unique Identifier : AIDSLINE MED/96222875; Grishchenko SV; Grishchenko AV; The effect of mesodiencephalic modulation (MDM) on peripheral blood immunocompetent cells during a mixed viral/bacterial infection was studied in 10 patients aged 15 to 35 suffering from acute respiratory diseases complicated by lacunar tonsillitis. Control group consisted of 10 patients aged 16 to 42. A course of MDM
[Nonisotopic variant of quantitative analysis using polymerase chain reaction for diagnosing HIV infection]: Vopr Virusol. 1996 Jan-Feb;41(1):44-5. Unique Identifier : AIDSLINE MED/96222885; Radiuk SN; Matsevich GR; Ryzhov KA; Lariukova TA
[Tuberculous prostatic abscess in a patient with AIDS]: Actas Urol Esp. 1995 Sep;19(8):655-61. Unique Identifier : AIDSLINE MED/96111694; Duarte Ojeda JM; Garcia Luzon A; Carrero VM; Vazquez S; Calahorra L; Passas J; Leiva O; Servicio de Urologia, Hospital Doce de Octubre, Universidad; Complutense, Madrid.; Despite of prostate abscesses having become an uncommon disease, a number of cases has been described lately specially in immunodepressed patients caused by infrequent agents, such as Mycobacterium tuberculosis. This paper describes the case of one HIV-positive patient, diagnosed with a prostate abscess within a tuber
Clinical features of HIV seropositive Zambian subjects.: Afr J Med Med Sci. 1995 Jun;24(2):173-8. Unique Identifier : AIDSLINE MED/96250265; Siziya S; Mwendapole R; Fleming AF; Biostatistics Unit, Tropical Diseases Research Centre, Ndola,; Zambia.; Data was collected from 1595 anti-HIV positive patients out of which 90% of the patients were from the Copperbelt province, and the rest from five out of the eight other provinces of Zambia . One-hundred and one positive HIV patients were less than 2 years of age, 69 were aged 2 to
The enzymatic antioxidant system in blood and glutathione status in human immunodeficiency virus (HIV)-infected patients: effects of supplementation with selenium or beta-carotene.: Am J Clin Nutr. 1996 Jul;64(1):101-7. Unique Identifier : AIDSLINE MED/96282507; Delmas-Beauvieux MC; Peuchant E; Couchouron A; Constans J; Sergeant C; Simonoff M; Pellegrin JL; Leng B; Conri C; Clerc M; Laboratoire Biochimie Medicale A, Universite Bordeaux II,; France.; To investigate the effects of selenium or beta-carotene supplementation in human immunodeficiency virus (HIV)-infected patients, who are known to have deficiencies of selenium and vitamin A, we evaluated the blood enzymatic antioxidant system, including superoxide dismutase (SOD), selenodependent glutathione peroxidas
Localization of human herpes-like virus type 8 in vascular endothelial cells and perivascular spindle-shaped cells of Kaposi's sarcoma lesions by in situ hybridization.: Am J Pathol. 1996 Jun;148(6):1741-8. Unique Identifier : AIDSLINE MED/96234258; Li JJ; Huang YQ; Cockerell CJ; Friedman-Kien AE; Department of Dermatology, New York University Medical Center,; New York, New York 10016, USA.; Kaposi s sarcoma (KS) is a neoplasm that develops as multifocal lesions characterized by a histological picture that includes irregularly shaped vascular spaces surrounded by perivascular and interstitial spindle-shaped cells, extravasated erythrocytes, and an inflammatory mononuclear cell infiltrate. Recently, the DN
Interferon-gamma-producing T cells in giant cell vasculitis represent a minority of tissue-infiltrating cells and are located distant from the site of pathology.: Am J Pathol. 1996 Jun;148(6):1925-33. Unique Identifier : AIDSLINE MED/96234276; Wagner AD; Bjornsson J; Bartley GB; Goronzy JJ; Weyand CM; Department of Medicine, Division of Rheumatology, Mayo Clinic and; Foundation, Rochester, Minnesota 55905, USA.; Giant cell vasculitis is an arteritis that predominantly affects medium- and large-sized arteries. Genetic risk factors and clonal expansion of selected CD4+ T cell specificities in the vascular lesions support the model that giant cell arteritis is a T-cell-driven disease. Interferon (IFN)-gamma production in the tis
Cytokine secretion and adhesion molecule expression by granuloma T lymphocytes in Mycobacterium avium infection.: Am J Pathol. 1996 Jun;148(6):1935-48. Unique Identifier : AIDSLINE MED/96234277; Sacco RE; Jensen RJ; Thoen CO; Sandor M; Weinstock J; Lynch RG; Dailey MO; Department of Pathology, University of Iowa College of Medicine,; Iowa City, IA 52242, USA.; Mice experimentally infected with Mycobacterium avium develop a chronic disease characterized by widespread noncaseating granulomas. In this report, we describe the phenotype and cytokine secretion profile of these granuloma-infiltrating effector T lymphocytes. In response to specific antigen, granuloma T cells and, t
Expression and cytokine regulation of glucocorticoid receptors in Kaposi's sarcoma.: Am J Pathol. 1996 Jun;148(6):1999-2008. Unique Identifier : AIDSLINE MED/96234282; Guo WX; Antakly T; Cadotte M; Kachra Z; Kunkel L; Masood R; Gill P; Department of Pathology, University of Montreal, Canada.; Development of Kaposi s sarcoma (KS) after glucocorticoid therapy has been observed in a variety of clinical states including human immunodeficiency virus-1 infection and recent in vitro studies provided evidence for a direct stimulation effect of glucocorticoid hormones on KS cell proliferation. The importance of glu
Human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) DNA in Kaposi's sarcoma lesions, AIDS Kaposi's sarcoma cell lines, endothelial Kaposi's sarcoma simulators, and the skin of immunosuppressed patients.: Am J Pathol. 1996 Jun;148(6):2009-16. Unique Identifier : AIDSLINE MED/96234283; Dictor M; Rambech E; Way D; Witte M; Bendsoe N; Department of Pathology, University of Lund Hospital, Lund,; Sweden.; We used the polymerase chain reaction on 63 tissue specimens of histologically staged classic Kaposi s sarcoma (KS) from 40 patients, 14 specimens from 14 acquired immune deficiency syndrome (AIDS)-KS cases (all from the same geographic area over a 10-year period), and peripheral blood mononuclear cells from 1 of the
Inhibition of human immunodeficiency virus type 1 wild-type and mutant reverse transcriptases by the phenyl ethyl thiazolyl thiourea derivatives trovirdine and MSC-127.: Antiviral Res. 1995 Dec;28(4):331-42. Unique Identifier : AIDSLINE MED/96264013; Zhang H; Vrang L; Backbro K; Lind P; Sahlberg C; Unge T; Oberg B; Medivir AB, Huddinge, Sweden.; A new class of very potent and selective non-nucleoside inhibitors of HIV reverse transcriptase (RT) has recently been identified. The prototype compound trovirdine (LY 300046 HCl) and one analogue, MSC-127, have been studied with respect to inhibition of wild-type HIV-1 RT and RT with various mutations known to give
Inhibition of neurotropic mouse retrovirus replication in glial cells by synthetic oligo(2'-O-methyl)ribonucleoside phosphorothioates.: Antiviral Res. 1995 Dec;28(4):359-68. Unique Identifier : AIDSLINE MED/96264015; Takase-Yoden S; Shibahara S; Morisawa H; Watanabe R; Institute of Life Science, Soka University, Hachioji, Tokyo,; Japan.; Synthetic oligo(2 -O-methyl)ribonucleoside phosphorothioate, FS-25, which is complementary to the splicing acceptor site of neurotropic mouse retrovirus (FrC6 virus), and non-complementary analogs including 2 -O-methylinosine homo oligomer (MIS-25), both inhibited viral infection in glial cells. In addition, FS-25 and
Vertical transmission of Kaposi's sarcoma.: Arch Dis Child. 1996 May;74(5):455-7. Unique Identifier : AIDSLINE MED/96263202; McCarthy GA; Kampmann B; Novelli V; Miller RF; Mercey DE; Gibb D; Department of Genitourinary Medicine, Camden and Islington; Community Health Services Trust, London.; AIDS related Kaposi s sarcoma is commonly seen in homosexual men, only occasionally in men and women with heterosexually acquired HIV, and extremely rarely in children. The case of an HIV infected mother and her vertically infected child who both developed visceral Kaposi s sarcoma is reported. It is proposed that the
[Seroprevalence of hepatitis C virus among persons visiting the Burundi health services]: Ann Soc Belg Med Trop. 1995 Dec;75(4):283-90. Unique Identifier : AIDSLINE MED/96213422; Ntakarutimana V; Delaporte E; Pollet D; Demedts P; Scharpe S; Universite du Burundi, Faculte des Sciences, Bujumbura,; Burundi.; The epidemiology of hepatitis C (HCV), especially on the African continent, is not well known. In this study, we investigated the presence of antibodies to HCV in 685 out-patients, seen in several health care centers or hospitals in different regions in Burundi from January to Feb
Establishment of peripheral blood and gingival T lymphocyte clones responsive to Porphyromonas gingivalis.: Aust Dent J. 1996 Apr;41(2):113-7. Unique Identifier : AIDSLINE MED/96248831; Gemmell E; Bartold PM; Seymour GJ; Department of Dentistry, University of Queensland.; T cells are central to the immune response to infection and studies have indicated a local immunoregulatory imbalance may exist in human periodontal disease. Since Porphyromonas gingivalis is generally recognized as a major periodontopathogen, the aim of this study was to establish T cell lines and clones specific to
Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases.: Biochem J. 1996 Mar 1;314 ( Pt 2):521-32. Unique Identifier : AIDSLINE MED/96239111; Vollenweider F; Benjannet S; Decroly E; Savaria D; Lazure C; Thomas G; Chretien M; Seidah NG; J.A. DeSeve Laboratories of Biochemical and Molecular; Neuroendocrinology, Montreal, Quebec, Canada.; We present here the pulse and pulse-chase analysis of the biosynthesis of the envelope glycoprotein gp160 and its intracellular processing by the subtilisin/kexin-like convertases furin, PACE4, PC1, PC5 and its isoform PC5/6-B. We demonstrate that furin and to a much lesser extent PACE4, PC5/6-B and PC1 are candidate
Synergistic binding of inhibitors to the protease from HIV type 1.: Biochem J. 1996 Apr 1;315 ( Pt 1):113-7. Unique Identifier : AIDSLINE MED/96207570; Asante-Appiah E; Chan WW; Department of Biochemistry, McMaster University, Hamilton,; Ontario, Canada.; Inhibition of the protease in HIV is a potentially useful approach for the treatment of AIDS. In the course of evaluating inhibitors of the HIV-1 protease, we observed a strong synergism between certain inhibitors that might be expected to bind to different sites in this enzyme. The binding affinity of carbobenzyloxyi
A novel monoclonal antibody to N-myristoyl glycine moiety found a new N-myristoylated HIV-1 p28gag protein in HIV-1-infected cells.: Biochem Biophys Res Commun. 1996 May 15;222(2):344-51. Unique Identifier : AIDSLINE MED/96222505; Furuishi K; Misumi S; Shoji S; Department of Biochemistry, Faculty of Pharmaceutical Sciences,; Kumamoto University, Japan.; A novel monoclonal antibody was raised against a synthetic N-myristoyl glycine that is characteristic of all N-myristoylated proteins. The immunoreaction suppressed in the presence of hemocyanin as well as albumin conjugated with N-myristoyl glycine and other N-myristoyl glycyl peptides, while underivatized and myrist
Cerebrospinal fluid and blood lymphocyte subpopulations following subarachnoid haemorrhage.: Br J Neurosurg. 1996 Feb;10(1):89-92. Unique Identifier : AIDSLINE MED/96259778; Mathiesen T; Lefvert AK; Department of Neurosurgery, Karolinska Hospital, Stockholm,; Sweden.; Lymphocyte subpopulations from 10 patients who had had a subarachnoid haemorrhage were analysed. In CSF, an increase of CD3 cells was found in two of ten, CD4 in one of ten, CD8 in three of ten, and CD19 in three of ten patients. Three patients with delayed ischaemic deficit (DID) showed a statistically significant in
Outcomes of a risk-reduction intervention with high-risk populations: the Harlem AIDS project.: AIDS Educ Prev. 1995 Oct;7(5):379-90. Unique Identifier : AIDSLINE MED/96113078; Deren S; Davis WR; Beardsley M; Tortu S; Clatts M; National Development and Research Institutes, Inc., New York,; USA.; Many studies of interventions with high-risk populations have reported reductions in risk behaviors. To assess effectiveness of interventions, data are also needed on the characteristics of subjects lost to follow-up, and on follow-up risk behaviors for subjects who were not participants in the intervention. This pape
Quasi-experimental evaluation of three AIDS prevention activities for maintaining knowledge, improving attitudes, and changing risk behaviors of high school seniors.: AIDS Educ Prev. 1995 Oct;7(5):391-402. Unique Identifier : AIDSLINE MED/96113079; Smith MU; Katner HP; Mercer University School of Medicine, Macon, Georgia 31201, USA.; Twelfth graders in a small southern city participated in one of three interventions: a question and answer (QA) session, a presentation by a person with AIDS (PWA), or a role-play activity (RP). A pre-intervention questionnaire assessed AIDS-related knowledge and attitudes. Immediate post-intervention questionnaires a
Condom awareness and use in the Arusha and Kilimanjaro regions, Tanzania: a population-based study.: AIDS Educ Prev. 1995 Oct;7(5):403-14. Unique Identifier : AIDSLINE MED/96113080; Mnyika KS; Klepp KI; Kvale G; Schreiner A; Seha AM; Department of Epidemiology & Biostatistics, Muhimbili University; College of Health Sciences, Dar es Salaam, Tanzania.; A cross-sectional study of condom awareness, perceived availability, and use was conducted using a questionnaire in the Arusha and Kilimanjaro regions in northern Tanzania . The questionnaire was administered to a random sample (n = 1,081) of males and females (15-54 years of age)
Perception of AIDS risk and high-risk behaviors in African-American methadone-dependent women.: AIDS Educ Prev. 1995 Oct;7(5):415-28. Unique Identifier : AIDSLINE MED/96113081; Harris RM; Kavanagh KH; School of Nursing, University of Maryland, Baltimore 21201, USA.; AIDS poses a particularly serious threat to African-American women who are or have been intravenous drug users. This study evaluated relationships among AIDS knowledge, perceptions of chances of contracting AIDS, and high-risk AIDS behaviors in 102 low-income African-American women from four methadone-maintenance clin
Stress, coping, and attitudes toward HIV treatment in injecting drug users: a qualitative study.: AIDS Educ Prev. 1995 Oct;7(5):429-42. Unique Identifier : AIDSLINE MED/96113082; Demas P; Schoenbaum EE; Wills TA; Doll LS; Klein RS; AIDS Research Program, Department of Epidemiology and Social; Medicine, Montefiore Medical Center, Albert Einstein College of; Medicine, Bronx, NY 10467, USA.; An exploratory study was conducted with 27 injecting drug users (IDUs) on psychosocial factors (stress, coping reactions, and attitudes toward HIV illness and treatment) which are relevant to treatment acceptance and adherence. A semi-structured interview was used to collect qualitative data in a sample of 13 seroposi
The Nurses' Attitudes About AIDS Scale (NAAS): development and psychometric analysis.: AIDS Educ Prev. 1995 Oct;7(5):443-54. Unique Identifier : AIDSLINE MED/96113083; Preston DB; Young EW; Koch PB; Forti EM; Dept. of Health Education and Nursing, Pennsylvania State; University, University Park 16802, USA.; This article describes the development and psychometric evaluation of the Nurses Attitudes About AIDS Scale (NAAS). Based on a review of the literature on attitude theory and measurement and on HIV/AIDS, 273 items were developed for inclusion in the scale. Content validity was established by a panel of ten nurses in
Pharmacists as HIV/AIDS information resources: survey of Alabama pharmacists.: AIDS Educ Prev. 1995 Oct;7(5):455-66. Unique Identifier : AIDSLINE MED/96113084; Binkley D; Waller L; Potts L; Bronstein J; Department of Health Behavior, University of Alabama at; Birmingham School of Public Health, USA.; Alabama pharmacists were surveyed by researchers from the University of Alabama at Birmingham s School of Public Health in collaboration with investigators at the Schools of Pharmacy at Auburn University and Stamford University as part of a statewide pharmacists demonstration project to mobilize pharmacists and pharm
Partitioning of HIV-1 Gag and Gag-related proteins to membranes.: Biochemistry. 1996 Apr 2;35(13):3933-43. Unique Identifier : AIDSLINE MED/96264770; Ehrlich LS; Fong S; Scarlata S; Zybarth G; Carter C; Department of Molecular Genetics & Microbiology, State University; of New York at Stony Brook, New York, 11794, USA.; The binding of HIV-1 Gag and Gag-related proteins to model membranes was examined using three experimental systems: (i) large unilamellar phospholipid vesicles (LUVs) and recombinant Gag purified from Escherichia coli; (ii) LUVs added to a mammalian cell extract in which Gag proteins were expressed by a coupled transc
Kinetics of G-quartet-mediated tetramer formation.: Biochemistry. 1996 Jun 18;35(24):8002-8. Unique Identifier : AIDSLINE MED/96264914; Wyatt JR; Davis PW; Freier SM; ISIS Pharmaceuticals, Inc., Carlsbad, California 92008, USA.; The phosphorothioate and phosphodiester oligodeoxynucleotides d(TTGGGGTT) form parallel-stranded tetramer structures stabilized by guanosine quartets. The phosphorothioate tetramer has been shown to inhibit human immunodeficiency virus (HIV) in vitro. The kinetics of association and dissociation of both tetramers have
[Attitude to incurable disease]: Aten Primaria. 1996 Apr 15;17(6):389-93. Unique Identifier : AIDSLINE MED/96243539; Fernandez Diaz R; Perez Suarez MC; Cossio Rodriguez I; Martinez Gonzalez P; Centro de Salud de Otero, Asturias.; OBJECTIVE. To find the opinions and attitudes of our patients regarding questions of incurable disease and death. DESIGN. A crossover, descriptive study. SETTING. 2 medical clinics and 2 nursing stations at 2 health centres. PATIENTS. 720 patients between 14 and 90 seeking health-care. Sampling of their appropriatenes
A proportional hazards model for arbitrarily censored and truncated data.: Biometrics. 1996 Jun;52(2):512-24. Unique Identifier : AIDSLINE MED/96310723; Alioum A; Commenges D; INSERM U 330, Universite de Bordeaux II, France.; Turnbull (1976, Journal of Royal Statistical Society, Series B 38, 290-295) proposed a method for nonparametric estimation of the distribution function when the data are incomplete because of censoring and truncation. However, as noted by Frydman (1994, Journal of Royal Statistical society, Series B 56, 71-74), Turnbu
Repair of the in vitro HIV-1-induced immunosuppression and blockade of the generation of functional suppressive CD8 cells by anti-alpha interferon and anti-Tat antibodies.: Biomed Pharmacother. 1996;50(1):13-8. Unique Identifier : AIDSLINE MED/96241011; Lachgar A; Bernard J; Bizzini B; Astgen A; Le Coq H; Fouchard M; Chams V; Feldman M; Burny A; Zagury JF; Universite Pierre et Marie Curie, Paris, France.; The acute human immunodeficiency virus type 1 (HIV-1) infection of activated peripheral blood mononuclear cells (PBMCs) from normal donors results in inhibition of cell proliferation and generation of functional suppressive T cells. Cultured HIV-1 infected PBMCs but not uninfected PBMCs, following irradiation, can inh
[Questionnaire survey of AIDS examination recipients at government-run public health center regarding AIDS awareness promotion and HIV examinations]: Nippon Koshu Eisei Zasshi. 1996 Apr;43(4):276-85. Unique Identifier : AIDSLINE MED/96254469; Hasegawa S; Sawa H; Shimizu K; Fujioka M; Tsushio M; Fujihara N; Ishikawa N; Shimizu M; Kato K; Denpo K; Yoshikawa I; Kanou E; Miyamoto H; Agematsu R; Sunagawa K; Tajima K; Department of Health, Aichi Prefecture, Japan.; An anonymous questionnaire survey was conducted among persons who had undergone screening for AIDS at public health centers under the auspices of 7 local government bodies (Hokkaido, Metropolitan Tokyo, Aichi Prefecture, Osaka Prefecture, Kobe City, Saga Prefecture, Okinawa Prefecture). There were 1,230 replies, for a
HIV infection and AIDS: attitudes and knowledge of Arizona pharmacists.: Ann Pharmacother. 1995 Dec;29(12):1218-23. Unique Identifier : AIDSLINE MED/96245733; Katz MD; Draugalis JR; Lai RP; Department of Pharmacy Practice, University of Arizona, Tucson; 85721, USA.; OBJECTIVE: To assess Arizona pharmacists attitudes and knowledge regarding HIV infection and AIDS. METHODS: Mailing of a 7-page survey, which included demographic and attitudinal items, as well as preparedness, comfort, and knowledge scales. SETTING: Randomly selected pharmacists registered and residing in Arizona. P
Glutathione in health and disease: pharmacotherapeutic issues.: Ann Pharmacother. 1995 Dec;29(12):1263-73. Unique Identifier : AIDSLINE MED/96245741; Lomaestro BM; Malone M; Department of Pharmacy, Albany Medical Center, Hospital, NY; 12208, USA.; OBJECTIVE: To review the current research and importance of glutathione (GSH) therapy in health and disease and to provide a basic overview of the widespread use and interest in this compound. DATA IDENTIFICATION: Articles were obtained via a MEDLINE search of the term glutathione in conjunction with specific disease
Use of zidovudine to prevent maternal transmission of HIV.: Ann Pharmacother. 1995 Dec;29(12):1287-8. Unique Identifier : AIDSLINE MED/96245745; Belgado BS; Hogan TT; University Medical Center, Jacksonville, FL 32209, USA.
AIDS and HIV-1 infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1996 Mar 15;6(11):99-100. Unique Identifier : AIDSLINE MED/96271808
The variety of human virus evolution.: Mol Phylogenet Evol. 1996 Feb;5(1):247-58. Unique Identifier : AIDSLINE MED/96264823; Fitch WM; Department of Ecology and Evolutionary Biology, University of; California, Irvine 92717, USA.; There have been many wise suggestions of ways that evolution may occur but those ways seem often hard to support with good examples. Viruses have proven to be replete with some of these items. This paper reviews work that shows: (1) very fast rates of evolution; (2) positive Darwinian selection with the selective pres
Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jul;12(3):213-20. Unique Identifier : AIDSLINE MED/96275629; Bolmstedt A; Sjolander S; Hansen JE; Akerblom L; Hemming A; Hu SL; Morein B; Olofsson S; Department of Clinical Virology, University of Goteborg, Sweden.; One of the functions of N-linked glycans of viral glycoproteins is protecting otherwise accessible neutralization epitopes of the viral envelope from neutralizing antibodies. The aim of the present study was to explore the possibility to obtain a more broadly neutralizing immune response by immunizing guinea pigs with
A human monoclonal antibody to HIV-1 gp41 with neutralizing activity against diverse laboratory isolates.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jul;12(3):221-32. Unique Identifier : AIDSLINE MED/96275630; Cotropia J; Ugen KE; Kliks S; Broliden K; Broliden PA; Hoxie JA; Srikantan V; Williams WV; Weiner DB; Department of Medicine, University of Pennsylvania School of; Medicine, Philadelphia, USA.; A potential component that may be useful for passive immunotherapy for HIV-1 is human monoclonal antibodies (HumAbs) possessing potent anti-HIV-1 activity that is directed against conserved regions of the envelope glycoprotein. Such antibodies would, in principle, have the ability to neutralize diverse isolates of HIV
T-cell homeostasis, competition, and drift: AIDS as HIV-accelerated senescence of the immune repertoire.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jul;12(3):233-48. Unique Identifier : AIDSLINE MED/96275631; Mittler JE; Levin BR; Antia R; Department of Biology, Emory University, Atlanta, Georgia, USA.; The observation that the density of CD8+ T-lymphocytes increases as the density of CD4+ T-cells declines in adult HIV-1/AIDS patients, together with evidence that the total density of T-cells is regulated (homeostasis) has led to the suggestion that competition between lineages, and classes of T-cells contributes to t
Switching from zidovudine to didanosine in patients with symptomatic HIV infection and disease progression. ddI Iberian Study Group.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jul;12(3):249-58. Unique Identifier : AIDSLINE MED/96275632; Gatell JM; Gonzalez-Lahoz J; Clotet B; Antunes F; Kasparova L; Gil-Aguado A; Saballs P; Santamaria JM; Podzamczer D; Miro JM; Jou A; Verdejo J; Doroana M; Thomis J; Hospital Clinic, Barcelona, Spain.; This study evaluated the efficacy of switching to didanosine in patients who were clinically or immunologically progressing despite zidovudine therapy. This multicenter, open-label study involved 400 patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC), who had tolerated zidovudine
Prenatal care and birth outcomes of a cohort of HIV-infected women.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jul;12(3):259-67. Unique Identifier : AIDSLINE MED/96275633; Turner BJ; McKee LJ; Silverman NS; Hauck WW; Fanning TR; Markson LE; Division of General Internal Medicine, Center for Research in; Medical Education and Health Care, Philadelphia, Pennsylvania,; USA.; Adequate prenatal care has been linked to improved birth outcomes in general populations but has not been assessed in HIV-infected women. We examined longitudinal claims files and vital statistics records for women in the New York State Medicaid HIV/AIDS data base delivering a singleton from 1985 through 1990. Adequac
No evidence of a higher risk of progression to AIDS in patients with HIV-1-related severe thrombocytopenia.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jul;12(3):268-75. Unique Identifier : AIDSLINE MED/96275634; Galli M; Musicco M; Gervasoni C; Ridolfo AL; Niero F; Rusconi S; Riva A; Voltolin L; Lupo A; Lovicu GF; Radice D; Moroni M; Clinica delle Malattie Infettive, University of Milan, Italy.; The prognostic role of platelet (PLT) counts was evaluated in a cohort of 1,533 HIV-1-infected subjects followed for a median of 21 months. Thrombocytopenia (TCP), defined as a PLT count
Increased numbers of granzyme-B-expressing cytotoxic T-lymphocytes in the small intestine of HIV-infected patients.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jul;12(3):276-81. Unique Identifier : AIDSLINE MED/96275635; Snijders F; Wever PC; Danner SA; Hack CE; ten Kate FJ; ten Berge IJ; Division of Infectious Diseases, Tropical Medicine and AIDS,; University of Amsterdam, The Netherlands.; The objective of this study was to determine whether granzyme B-expressing cells, which identify activated cytotoxic lymphocytes, are present in the small intestinal mucosa of human immunodeficiency virus (HIV)-infected patients with and without diarrhea. Therefore, duodenal biopsy specimens from 29 HIV-infected patie
Risk behavior and HIV seroincidence among out-of-treatment injection drug users: a four-year prospective study.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jul;12(3):282-9. Unique Identifier : AIDSLINE MED/96275636; Wiebel WW; Jimenez A; Johnson W; Ouellet L; Jovanovic B; Lampinen T; Murray J; O'Brien MU; Division of Epidemiology-Biostatistics, School of Public Health,; University of Illinois at Chicago, USA.; We monitored trends in HIV risk behaviors and seroconversion among out-of-treatment injection drug users (IDUs) receiving street-based outreach intervention. Beginning in 1988, 641 HIV-seronegative IDUs were recruited by targeted sampling methods to reflect broader IDU populations and were followed for 4 years (1988-1
Acceptability of interventions to reduce mother-to-child transmission of HIV-1 in west Africa.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jul;12(3):290-2. Unique Identifier : AIDSLINE MED/96275637; Cartoux M; Msellati P; Rouamba O; Coulibaly D; Meda N; Blibolo D; Mandelbrot L; Van de Perre P; Dabis F; Centre Muraz/O.C.C.G.E., Bobo-Dioulasso, Burkina Faso.; Would HIV-1-positive pregnant African women use interventions of AIDS testing, medication (oral or vaginal), and vaginal disinfection to reduce the likelihood of HIV-1 transmission to their child? In this pilot study in two west African cities (Abidjan, Cote d Ivoire and Bobo-
Tuberculosis among AIDS patients in the United States, 1993.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jul;12(3):293-7. Unique Identifier : AIDSLINE MED/96275638; Jones JL; Burwen DR; Fleming PL; Ward JW; Division of HIV/AIDS Prevention and Division of Tuberculosis; Elimination, Centers for Disease Control and Prevention, Atlanta,; Georgia, USA.; To evaluate the demographic characteristics, risk factors, and reported mortality of adults and adolescents with AIDS and tuberculosis (TB), we analyzed surveillance reports of persons with AIDS from state, territorial, and local health departments. Of 72,306 persons with AIDS diagnosed in 1993, 3,589 (5%) were report
Sequence variation and subtyping of human and simian T-cell lymphotropic virus type I strains from South Africa.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jul;12(3):298-302. Unique Identifier : AIDSLINE MED/96275639; Englebrecht S; van Rensburg EJ; Robson BA; Department of Medical Virology, University of Stellenbosch and; Tygerberg Hospital, Tygerberg, South Africa.; We report on the subtyping of South African primate T-cell lymphotropic virus type I (PTLV-I) strains by investigating the LTR region using sequence analysis and restriction fragment length polymorphism (RFLP) techniques. DNA from either uncultured peripheral blood mononuclear cells (PBMCs); cultured PBMC or cell line
Delayed-type hypersensitivity testing in Tanzanian adults with HIV infection.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jul;12(3):303-8. Unique Identifier : AIDSLINE MED/96275640; Miller WC; Thielman NM; Swai N; Cegielski JP; Shao J; Ting D; Mlalasi J; Manyenga D; Lallinger GJ; Duke University Medical Center, Durham, North Carolina, USA.; Delayed-type hypersensitivity (DTH) testing and total lymphocyte counts as measures of cell-mediated immune function were assessed for medical patients in Dar es Salaam, Tanzania . DTH testing was performed with the Multitest CMI device which simultaneously administers seven antig
Replacing time since human immunodeficiency virus infection by marker values in predicting residual time to acquired immunodeficiency syndrome diagnosis. Multicenter AIDS Cohort Study.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jul;12(3):309-16. Unique Identifier : AIDSLINE MED/96275641; Shi M; Taylor JM; Currier RJ; Tang H; Hoover DR; Chmiel JS; Bryant JL; Department of Biostatistics, UCLA School of Public Health, Los; Angeles, California, USA.; It is widely assumed that the time since human immunodeficiency virus (HIV) infection is an important indicator of HIV disease stage, yet for most infected individuals the date of infection is unknown. We consider whether marker values, such as CD4 lymphocyte number or percent and levels of serum beta2 microglobulin o
Konzo, an epidemic spastic paraparesis in Africa, is not associated with antibodies to HTLV-I, HIV, or HIV gag-encoded proteins [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jul;12(3):317-8. Unique Identifier : AIDSLINE MED/96275642; Tylleskar T; Banea M; Bottiger B; Thorstensson R; Biberfeld G; Rosling H
Hyperuricemia and progression of HIV disease [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jul;12(3):318-9. Unique Identifier : AIDSLINE MED/96275643; Manfredi R; Mastroianni A; Coronado OV; Chiodo F
Effects of human immunodeficiency virus type 1 infection on programmed cell death in the presence or absence of Bcl-2.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Aug 1;12(4):321-8. Unique Identifier : AIDSLINE MED/96302265; Park IW; Kondo E; Bergeron L; Park J; Sodroski J; Division of Human Retrovirology, Dana-Farber Cancer Institute,; Boston, MA 02115, USA.; The effect of human immunodeficiency virus (HIV-1) infection on the programmed cell death of CD4+ lymphocytes was studied by using Jurkat cells stably expressing high levels of the Bcl-2 protein (Jurkat-Bcl2) or control cells (Jurkat-P). Both Jurkat-Bcl2 and Jurkat-P cells exhibited surface CD4 expression adequate to
Transcriptional effects of superinfection in HIV chronically infected T cells: studies in dually infected clones.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Aug 1;12(4):329-42. Unique Identifier : AIDSLINE MED/96302266; Kim JH; McLinden RJ; Mosca JD; Burke DS; Boswell RN; Birx DL; Redfield RR; Division of Retrovirology, Walter Reed Army Institute of; Research, Rockville, MD 20850, USA.; We had previously shown that chronically infected ACH-2 cells (HIVLAI) could be superinfected with HIVRF, that the frequency of superinfection increased with time, and that the transcription of the superinfecting virus exceeded that of the host HIVLAI provirus. In contrast, ACH-2 cells superinfected with a nef-substit
Inhibition of HIV replication by sense and antisense rev response elements in HIV-based retroviral vectors.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Aug 1;12(4):343-51. Unique Identifier : AIDSLINE MED/96302267; Kim JH; McLinden RJ; Mosca JD; Vahey MT; Greene WC; Redfield RR; University of Maryland, Medical Biotechnology Center, Baltimore; 21201, USA.; The life cycle of human immunodeficiency virus type 1 (HIV-1) is critically dependent on the transregulatory proteins Tat and Rev. Tat increases the production of HIV-specific mRNAs by direct binding to the transactivation response (TAR) element located at the 5 end of all HIV transcripts. In contrast, Rev uses a com
Molecular cloning of full-length HIV-1 genomes directly from plasma viral RNA.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Aug 1;12(4):352-7. Unique Identifier : AIDSLINE MED/96302268; Fang G; Weiser B; Visosky AA; Townsend L; Burger H; Wadsworth Center, New York State Department of Health, Albany; 12201-2002, USA.; Human immunodeficiency virus type 1 (HIV-1) in plasma reflects the replicating virus population at any point in time in vivo. Studies of the relationship of the complete HIV-1 genome to pathogenesis therefore need to focus on plasma virions. Since dual infections and recombination can occur in vivo, cloning an intact
Early clinical markers and CD4 percentage in subjects with human immunodeficiency virus infection.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Aug 1;12(4):358-62. Unique Identifier : AIDSLINE MED/96302269; Wallace MR; Moss RB; Beecham HJ 3rd; Grace CJ; Hersh EM; Peterson E; Murphy R; Shepp DH; Siegal FP; Turner JL; Safrin S; Carlo DJ; Levine AM; U.S. Naval Medical Center-San Diego, California, USA.; In a clinical trial involving asymptomatic, HIV-seropositive subjects treated with either the HIV-1 immunogen (an inactivated, gp120-depleted HIV-1 virus in incomplete Freund s adjuvant) or an adjuvant control, we examined the relationship between changes in the percentage of CD4 cells over time and early clinical mar
Phase 1 study of combination therapy with L-697,661 and zidovudine. The ACTG 184 Protocol Team.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Aug 1;12(4):363-70. Unique Identifier : AIDSLINE MED/96302270; Schooley RT; Campbell TB; Kuritzkes DR; Blaschke T; Stein DS; Rosandich ME; Phair J; Pottage JC; Messari F; Collier A; Kahn J; University of Colorado Health Sciences Center, Denver 80262, USA.; We performed a pilot study that examined the clinical and pharmacokinetic interactions between zidovudine (ZDV) and a pyridinone derivative, L-697-661. The results indicate that the drugs were well tolerated, with no important pharmacokinetic interactions, when administered concomitantly for as long as 8 weeks. Althou
Lifetime cost of human immunodeficiency virus-related health care.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Aug 1;12(4):371-8. Unique Identifier : AIDSLINE MED/96302271; Hurley SF; Kaldor JM; Gardiner S; Carlin JB; Assuncao RM; Evans DB; Department of Public Health and Community Medicine, University of; Melbourne, Carlton, Victoria, Australia.; Estimates of the lifetime cost of illnesses are needed for temporal and international comparisons and for assessment of the efficiency of prevention strategies. The goal of the present study was to estimate the average present value, at both the time of diagnosis and the time of seroconversion, of the lifetime cost of
Predictors of resource utilization for hospitalized patients with Pneumocystis carinii pneumonia (PCP): a summary of effects from the multi-city study of quality of PCP care.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Aug 1;12(4):379-85. Unique Identifier : AIDSLINE MED/96302272; Horner RD; Bennett CL; Achenbach C; Rodriguez D; Adams J; Gilman SC; Cohn SE; Dickinson GM; DeHovitz JA; Weinstein RA; Department of Medicine, Lakeside VA Medical Center (111),; Chicago, IL 60611, USA.; To determine whether patient and hospital characteristics were significantly associated with variations in Pneumocystis carinii (PCP) care and outcomes, we analyzed the use of diagnostic tests, intensive care units (ICUs), anti-PCP medications for persons hospitalized with human immunodeficiency virus (HIV)-related PC
Pilot randomized controlled trial of Chinese herbal treatment for HIV-associated symptoms.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Aug 1;12(4):386-93. Unique Identifier : AIDSLINE MED/96302273; Burack JH; Cohen MR; Hahn JA; Abrams DI; AIDS Program, San Francisco General Hospital, California, USA.; We wished to determine the short-term safety and efficacy of a Chinese medicinal herb preparation in treating symptoms of human immunodeficiency virus (HIV) infection in a 12-week randomized, double-blind, placebo-controlled clinical trial in a University-affiliated acquired immunodeficiency syndrome (AIDS) clinic at
Analysis of an HIV-infected cohort followed for as long as 15 years after seroconversion.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Aug 1;12(4):394-9. Unique Identifier : AIDSLINE MED/96302274; Vallely PJ; Mani GS; Stoddart RW; Cleator GM; Lucas GS; Department of Pathological Sciences, University of Manchester,; U.K.; Data from a cohort of 62 HIV-positive individuals with hemophilia or von Willebrands disease infected for a maximum period of 15 years were analyzed. The relation between CD4+ and total lymphocyte counts and their rate of decline was analyzed with respect to age at seroconversion, time of seroconversion, and developme
Characteristics of HIV-infected pregnant women in the Bahamas.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Aug 1;12(4):400-5. Unique Identifier : AIDSLINE MED/96302275; Gomez MP; Bain RM; Major C; Gray H; Read SE; Princess Margaret Hospital, Department of Public Health, Ministry; of Health, Nassau, Bahamas.; The Commonwealth of the Bahamas has one of the highest rates of acquired immunodeficiency syndrome (AIDS) in the English-speaking Caribbean. A seroprevalence study of pregnant women attending antenatal clinics in New Providence in 1990-91 showed that of 3,914 pregnant women tested
Interest among gay/bisexual men in greater Boston in participating in clinical trials of preventive HIV vaccines.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Aug 1;12(4):406-12. Unique Identifier : AIDSLINE MED/96302276; Gross M; Seage GR; Mayer KH; Goldstein RS; Losina E; Wold C; Abt Associates, Cambridge, MA, USA.; To estimate interest in HIV preventive vaccine trials, we administered questionnaires to two otherwise demographically similar cohorts of older (mean 40 years) and younger (mean 23 years) gay men in Boston. Questionnaire responses were linked to concurrent behavioral and demographic data. Univariate analyses, performe
Costs of HIV+/AIDS at CD4+ counts disease stages based on treatment protocols.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Aug 1;12(4):413-20. Unique Identifier : AIDSLINE MED/96302277; Gable CB; Tierce JC; Simison D; Ward D; Motte K; State and Federal Associates, Alexandria, VA 22314, USA.; We report treatment protocols for HIV+/AIDS patients by CD4+ counts (T-lymphocyte cells/mm3: > or = 500, 499-200, 199-50, and
Performance of a modified HIV-1 p24 antigen assay for early diagnosis of HIV-1 infection in infants and prediction of mother-to-infant transmission of HIV-1 in Dar es Salaam, Tanzania.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Aug 1;12(4):421-6. Unique Identifier : AIDSLINE MED/96302278; Lyamuya E; Bredberg-Raden U; Massawe A; Urassa E; Kawo G; Msemo G; Kazimoto T; Ostborn A; Karlsson K; Mhalu F; Biberfeld G; Department of Microbiology/Immunology, Muhimbili University; College of Health Sciences, Dar es Salaam, Tanzania.; The aim of this study was to determine the utility of an amplified human immunodeficiency virus type 1 (HIV-1) p24 antigen (ag) assay using heated plasma or serum samples for the early diagnosis of HIV-1 infection in infants and for the prediction of the risk of mother-to-infant (MTI) transmission of HIV-1 in Dar es S
Correlation of HIV-1 RNA levels in plasma and heterosexual transmission of HIV-1 from infected transfusion recipients [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Aug 1;12(4):427-8. Unique Identifier : AIDSLINE MED/96302279; Lee TH; Sakahara N; Fiebig E; Busch MP; O'Brien TR; Herman SA
HTLV-I/II indeterminate serology and natural killer cell expansion [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Aug 1;12(4):428-31. Unique Identifier : AIDSLINE MED/96302280; Picchio GR; Bare P; Savignano R; Perez-Bianco R; Yamashita M; Hayami M
Prevalence of and risk factors for HTLV-I and HTLV-II infection among patients at a hospital in the south Bronx, New York [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Aug 1;12(4):431-2. Unique Identifier : AIDSLINE MED/96302281; Factor SH; Irwin KL; Lal RB; Rudolph D; Weber JT; Olivo N; Ernst J
Immunologic changes associated with strenuous exercise.: Clin J Sport Med. 1996 Apr;6(2):140. Unique Identifier : AIDSLINE MED/96254843; Nieman DC; Appalachian State University, Boone, North Carolina, USA.
Nucleoside-analogue resistance involves the p66 subunit of HIV-1 RT.: Nat Struct Biol. 1996 Jul;3(7):579-80. Unique Identifier : AIDSLINE MED/96266344; Boyer PL; Hughes SH; ABL-Basic Research Program, NCI-Frederick Cancer Research and; Development Center, Maryland 21702-1201, USA.
The tuberculosis story: from Koch to the year 2000.: Caduceus. 1996 Spring;12(1):43-60. Unique Identifier : AIDSLINE MED/96248852; Zaki MH; Hibberd ME; Public Health of Suffolk County, New York, USA.
Specific detection of the microsporidia Encephalitozoon intestinalis in AIDS patients.: C R Acad Sci III. 1996 Jan;319(1):39-43. Unique Identifier : AIDSLINE MED/96238508; Ombrouck C; Desportes-Livage I; Achbarou A; Gentilini M; INSERM U, Paris, France.; The microsporidia Encephalitozoon intestinalis is an opportunistic pathogen responsible for severe gastrointestinal diseases and disseminated infection in AIDS patients. No light-microscopical method allows the specific detection of this unicellular parasite and up to this date, only electron microscopy could confirm
Thalidomide for aphthous ulcers in patients infected with the human immunodeficiency virus.: Am J Health Syst Pharm. 1996 Feb 15;53(4):368, 371-2, 378. Unique Identifier : AIDSLINE MED/96225016; Weidle PJ; Department of Pharmacy Services, University of Maryland Medical; System, Baltimore 21201, USA.
Thalidomide in diseases associated with human immunodeficiency virus infection.: Am J Health Syst Pharm. 1996 Feb 15;53(4):429-31. Unique Identifier : AIDSLINE MED/96225025; Minor JR; Piscitelli SC; Pharmacy Department, Warren G. Magnuson Clinical Center, National; Institues of Health, Bethesda, MD 20892-1196, USA.
Dual function of Drosophila cells as APCs for naive CD8+ T cells: implications for tumor immunotherapy.: Immunity. 1996 Jun;4(6):555-64. Unique Identifier : AIDSLINE MED/96256834; Sun S; Cai Z; Langlade-Demoyen P; Kosaka H; Brunmark A; Jackson MR; Peterson PA; Sprent J; Department of Immunology, The Scripps Research Institute, La; Jolla, California 92037, USA.; With unseparated mouse spleen cells as responders, Drosophila cells expressing MHC class I (L(d)) molecules alone lead to peptide-specific responses of CD8+ cells in the absence of exogenous cytokines. Under these conditions, DNA released from dying cells stimulates the B cells in spleen to up-regulate costimulatory m
The impact of HIV-1 infection on child health in sub-Saharan Africa: the burden on the health services.: Trop Med Int Health. 1996 Feb;1(1):3-14. Unique Identifier : AIDSLINE MED/96273037; Walraven G; Nicoll A; Njau M; Timaeus I; Sumve Designated District Hospital, Mwanza, Tanzania.; HIV-1 infection in sub-Saharan Africa is resulting in substantial child mortality and an increase in the number of sick children presenting to health services. Many of the sick children come to health centres and hospitals, inflating numbers on paediatric wards. The presentations of childhood HIV-1 infection are many
Post-natal incidence of HIV-I infection among children in a rural Ugandan population: no evidence for transmission other than mother to child.: Trop Med Int Health. 1996 Feb;1(1):81-5. Unique Identifier : AIDSLINE MED/96273045; Mulder DW; Nunn A; Kamali A; Kengeya-Kayondo JF; Medical Research Council Programme on AIDS in Uganda (MRC),; Uganda Virus Research Institute, Entebbe, Uganda.; We conducted a prospective cohort study to determine the post-natal incidence of and possible transmission routes for HIV-I infection in rural Ugandan children. The cohort consisted of the population of a cluster of 15 villages in Masaka District, south-west Uganda, and was enrolled in 1989-1990 through a demographic
Isolation and characterization of a new subtype A variant of human immunodeficiency virus type I from Nigeria.: Trop Med Int Health. 1996 Feb;1(1):97-106. Unique Identifier : AIDSLINE MED/96273047; Olaleye DO; Sheng Z; Howard TM; Rasheed S; Laboratory of Viral Oncology and AIDS Research, University of; Southern California, School of Medicine, Los Angeles 90032-3626,; USA.; We have isolated a new variant of HIV-1 from Nigeria , Africa. The virus was recovered from the peripheral blood mononuclear cells (PBMCs) of an apparently healthy 23-year-old male from Ibadan, Nigeria. The in vitro studies indicated that the virus was highly cytopathic and replica
HIV and India: looking into the abyss.: Trop Med Int Health. 1996 Jun;1(3):295-304. Unique Identifier : AIDSLINE MED/96273075; Pais P; Department of Medicine, St John's Medical College Hospital,; Bangalore, India.; Serosurveillance of high risk groups started in India in October 1985. The first positive cases were detected in 1986. As of mid-1994, official figures stood at 15000 HIV positive cases and 559 cases of AIDS. This is most certainly an underestimate because of under reporting. Among
Radio immune Western blotting: a possible solution to indeterminate conventional Western blotting results for the serodiagnosis of HIV infections.: New Microbiol. 1996 Jan;19(1):85-90. Unique Identifier : AIDSLINE MED/96274053; Portincasa P; Conti G; Chezzi C; Istituto di Microbiologia, Facolta di Medicina e Chirurgia,; Universita degli studi di Parma, Italy.; Western blot is used worldwide as a confirmatory assay after a positive or doubtful ELISA result in the serodiagnosis of HIV infections. Despite the use of this test some results may be not definitive due to the presence in Western blot of only few or a single band to HIV protein. This result has been defined as indet
Progress towards a vaccine to prevent sexual transmission of HIV.: Nat Med. 1996 Jul;2(7):751-2. Unique Identifier : AIDSLINE MED/96266325; Miller CJ; McGhee JR; California Regional Primate Research Center, University of; California Davis 95616, USA.
Extensive polymorphisms observed in HIV-1 clade B protease gene using high-density oligonucleotide arrays.: Nat Med. 1996 Jul;2(7):753-9. Unique Identifier : AIDSLINE MED/96266326; Kozal MJ; Shah N; Shen N; Yang R; Fucini R; Merigan TC; Richman DD; Morris D; Hubbell E; Chee M; Gingeras TR; Department of Molecular Biology, Affymetrix, Santa Clara,; California 95051, USA.; Naturally occurring mutations in HIV-1-infected patients have important implications for therapy and the outcome of clinical studies. However, little is known about the prevalence of mutations that confer resistance to HIV-1 protease inhibitors in isolates derived f
Ordered accumulation of mutations in HIV protease confers resistance to ritonavir.: Nat Med. 1996 Jul;2(7):760-6. Unique Identifier : AIDSLINE MED/96266327; Molla A; Korneyeva M; Gao Q; Vasavanonda S; Schipper PJ; Mo HM; Markowitz M; Chernyavskiy T; Niu P; Lyons N; Hsu A; Granneman GR; Ho DD; Boucher CA; Leonard JM; Norbeck DW; Kempf DJ; Department of Anti-Infective Research, Abbott Laboratories,; Abbott Park, Illinois 60064, USA.; Analysis of the HIV protease gene from the plasma of HIV-infected patients revealed substitutions at nine different codons selected in response to monotherapy with the protease inhibitor ritonavir . Mutants at valine-82, although insufficient to confer
Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques.: Nat Med. 1996 Jul;2(7):767-75. Unique Identifier : AIDSLINE MED/96266328; Lehner T; Wang Y; Cranage M; Bergmeier LA; Mitchell E; Tao L; Hall G; Dennis M; Cook N; Brookes R; Klavinskis L; Jones I; Doyle C; Ward R; Department of Immunology, United Medical School, Guy's Hospital,; London, UK.; Prevention of sexually transmitted HIV infection was investigated in macaques by immunization with a recombinant SIV (simian immunodeficiency virus) envelope gp 120 and core p27 vaccine. In two independent series of experiments, we used the novel targeted iliac lymph node (TILN) route of immunization, aiming close to
Attitudes and behavior of HIV-infected patients concerning dental care.: J Can Dent Assoc. 1996 Jan;62(1):63-9. Unique Identifier : AIDSLINE MED/96226718; McCarthy GM; Haji FS; Mackie ID; Faculty of Dentistry, University of Western Ontario.; This preliminary, descriptive study investigated the behavior and attitudes of HIV-infected patients concerning dental care. A self-administered, anonymous questionnaire was completed by 101 of 102 consecutive HIV-infected adults (mean age 36 years). Since the diagnosis of HIV infection, 81 respondents reported that t
The XI International Conference on AIDS: at the crossroads of hope and urgency [editorial]: Can Med Assoc J. 1996 Jul 1;155(1):53-4. Unique Identifier : AIDSLINE MED/96269362; Schechter MT; This month Canada will host the largest conference ever held on the worldwide epidemic of AIDS. More than 12,000 participants from over 130 countries are expected to convene in Vancouver from July 7 to 12 for the XI International Conference on AIDS. As at previous conferences, the
Regulations govern semen donations [news]: Can Med Assoc J. 1996 Jul 1;155(1):89-90. Unique Identifier : AIDSLINE MED/96269365
The reality of despair: AIDS in Malawi.: Can Med Assoc J. 1996 Jul 1;155(1):91-2. Unique Identifier : AIDSLINE MED/96269366; Needham D; McMaster University Hamilton. medlib@unza.zm; While completing a recent medical elective in the Central African country of Malawi , medical student Dale Needham learned firsthand that HIV/AIDS represents a true pandemic in Africa. By the end of 1993, Malawi had the continent s highest per capita number of cumulative reported AI
Identification of a novel protein (VBP-1) binding to the von Hippel-Lindau (VHL) tumor suppressor gene product.: Cancer Res. 1996 Jul 1;56(13):2881-5. Unique Identifier : AIDSLINE GENBANK/U56833; Tsuchiya H; Iseda T; Hino O; Department of Experimental Pathology, Cancer Institute, Tokyo,; Japan.; The tumor suppressor VHL gene product (pVHL), recently reported to bind to elongins B and C, is thought to regulate transcription elongation. To establish whether the VHL gene may have other functions, we here searched for additional cellular protein(s) that might bind to pVHL using a two-hybrid system and identified
The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.: Cell. 1996 Jun 28;85(7):1135-48. Unique Identifier : AIDSLINE MED/96270515; Choe H; Farzan M; Sun Y; Sullivan N; Rollins B; Ponath PD; Wu L; Mackay CR; LaRosa G; Newman W; Gerard N; Gerard C; Sodroski J; Division of Human Retrovirology Dana-Farber Cancer Institute,; Boston, Massachusetts 02115, USA.; We examined the ability of chemokine receptors and related G protein-coupled receptors to facilitate infection by primary, clinical HIV-1 isolates. CCR5, when expressed along with CD4, the HIV-1 receptor, allowed cell lines resistant to most primary HIV-1 isolates to be infected. CCR3 facilitated infection by a more r
A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors.: Cell. 1996 Jun 28;85(7):1149-58. Unique Identifier : AIDSLINE MED/96270516; Doranz BJ; Rucker J; Yi Y; Smyth RJ; Samson M; Peiper SC; Parmentier M; Collman RG; Doms RW; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia 19104, USA.; Here, we show that the beta-chemokine receptor CKR-5 serves as a cofactor for M-tropic HIV viruses. Expression of CKR-5 with CD4 enables nonpermissive cells to form syncytia with cells expressing M-tropic, but not T-tropic, HIV-1 env proteins. Expression of CKR-5 and CD4 enables entry of a M-tropic, but not a T-tropic
A role for Th2 T-memory cells in early airway obstruction.: Cell Immunol. 1996 Jun 15;170(2):185-94. Unique Identifier : AIDSLINE MED/96258291; Bell SJ; Metzger WJ; Welch CA; Gilmour MI; Section of Allergy/Immunology, East Carolina University School of; Medicine, Greenville, North Carolina 27858, USA.; stephenb@boehringeringelheim.com; The role of T-cell memory in late-phase allergic lung inflammation is not well defined. To evaluate the role of systemic T-cell memory in allergic late-phase lung inflammation, BALB/c mice were injected intraperitoneally with ovalbumin (OVA) or ragweed (RW) allergens (Test I and Test II groups) or saline (control grou
Splenic CD4+ and CD8+ T cells from influenza immune mice concurrently produce in vitro IL2, IL4, and IFN-gamma.: Cell Immunol. 1996 Jun 15;170(2):222-9. Unique Identifier : AIDSLINE MED/96258295; Falchetti R; Lanzilli G; Casalinuovo IA; Gaziano R; Palamara AT; Di Francesco P; Ravagnan G; Garaci E; Department of Experimental Medicine and Biochemical Sciences,; University of Rome, Italy.; The cytokine responses exerted by virus-primed spleen T cells upon in vitro restimulation were studied. Spleen cells obtained from mice injected intraperitoneally with A/PR8 (H1N1) influenza virus (PR8) were restimulated in vitro with UV-inactivated PR8 virus. The percentage of both CD4+ and CD8+ T cells producing IL2
T cells with two Tcrbeta chains and reactivity to both MHC/idiotypic peptide and superantigen.: Cell Immunol. 1996 Jun 15;170(2):283-90. Unique Identifier : AIDSLINE MED/96258302; Munthe LA; Blichfeldt E; Sollien A; Dembic Z; Bogen B; Institute of Immunology and Rheumatology, University of Oslo,; Oslo, Norway.; It is thought that Tcrbeta genes are effectively allelically excluded, while Tcralpha genes are not. We report here that endogenous Tcrbeta genes are expressed on as much as 5-7% of CD4+ T cells in 8-week-old Tcralphabeta-transgenic mice. In this model, the transgenic Tcr recognizes residues 91 - 101 of a lambda2(315)
The ENT manifestations of HIV infection in children.: Clin Otolaryngol. 1996 Feb;21(1):30-6. Unique Identifier : AIDSLINE MED/96289638; Hadfield PJ; Birchall MA; Novelli V; Bailey CM; Department of Paediatric Otolaryngology, Great Ormond Street; Hospital for Children NHS, London, UK.; This study identified the ENT symptoms of 66 HIV infected children over an 8 year period (1986-1993) at Great Ormond Street Hospital for Children. The incidence, nature and age of onset of ENT symptoms were investigated; 91% of the children had ENT symptoms, the most common being cervical lymphadenopathy, oro-oesophag
Normal levels of allo- but increased levels of potentially autoreactive antibodies against ABO histo-blood group antigens in AIDS patients.: Clin Immunol Immunopathol. 1996 Jul;80(1):96-100. Unique Identifier : AIDSLINE MED/96258198; Friedli F; Rieben R; Wegmuller E; Moerenhout M; Nydegger UE; Medical Department, Regional Hospital Interlaken, Bern,; Switzerland.; The aim of our study was to investigate the immune response of human immunodeficiency virus (HIV)-infected patients in relation to the naturally occurring ABO histo-blood group antibodies. Despite markedly elevated levels of total IgM/G/A, anti-A/B isotypes revealed no significant different mean levels in AIDS patient
Ga-67 scintigraphy in a patient with adult T-cell leukemia/lymphoma.: Clin Nucl Med. 1995 Dec;20(12):1102-3. Unique Identifier : AIDSLINE MED/96229202; Kinoshita T; Ishii K; Naganuma H; Endoh F; Department of Radiology, Sendai Municipal Hospital, Japan.
Sociodemographic profile of children affected by AIDS in Addis Abeba.: Ethiop Med J. 1995 Oct;33(4):227-34. Unique Identifier : AIDSLINE MED/96276811; Bedri A; Kebede S; Negassa H; Department of Paediatrics and Child Health, Faculty of Medicine,; Addis Abeba University.; A survey was conducted in Addis Abeba between October 2, 1993 and December 10, 1993 to assess orphanhood due to AIDS deaths. It was possible to trace only 1,047 AIDS cases among residents of Addis Abeba. During the survey, 59% of the cases and 16% of their spouses were already dead. The total number of children born t
HIV/AIDS awareness, knowledge and practice in patients with sexually transmitted diseases.: Ethiop Med J. 1996 Jan;34(1):25-32. Unique Identifier : AIDSLINE MED/96276820; Ashebir DZ; Adigrat Hospital, Tigray, Ethiopia.; Patients diagnosed to have sexually transmitted diseases in one month at the Adigrat Health Centre were interviewed to determine knowledge about means of transmission and prevention of HIV/AIDS and practice of high risk behaviour. In this study done in October and November 1992, of a total of 812 patients aged between
Anti-oxidants and apoptosis.: Biochem Soc Trans. 1996 Feb;24(1):229-33. Unique Identifier : AIDSLINE MED/96230424; McGowan AJ; Fernandes RS; Samali A; Cotter TG; Department of Biochemistry, University College, Cork, Ireland.
Glutamine requirement of proliferating T lymphocytes.: Biochem Soc Trans. 1996 Feb;24(1):78S. Unique Identifier : AIDSLINE MED/96230518; Yaqoob P; Calder PC; Department of Biochemistry, University of Oxford, UK.
Heat-shock proteins (Hsps)-reactive T-cells in inflammatory disease.: Biochem Soc Trans. 1996 Feb;24(1):84S. Unique Identifier : AIDSLINE MED/96230524; Bell CG; UIC, Coll. Med., Dept. Micro./Immuno., Chicago, IL. 60612, USA.
Speculations on the influence of electromagnetism on genomic and associated structures.: J Int Med Res. 1996 Jan-Feb;24(1):1-11. Unique Identifier : AIDSLINE MED/96231147; Jacobson JI; Institute of Theoretical Physics and Advanced Studies for; Biophysical Research, Jupiter, Florida, USA.; Recent clinical and experimental works in the area of bioelectromagnetics are reviewed and considered from a physical viewpoint. An equation relating the intrinsic (or rest ) energy of a charged particle with its energy of interaction in an externally applied magnetic field is proposed. This equation is intended to r
Granulocyte-colony stimulating factor and erythropoietin therapy in children with human immunodeficiency virus infection.: J Int Med Res. 1996 Jan-Feb;24(1):115-21. Unique Identifier : AIDSLINE MED/96231161; Zuccotti GV; Plebani A; Biasucci G; Clerici-Schoeller M; Banderali G; Decarlis S; Startari R; Riva E; 5th Paediatric Department, University of Milan, Italy.; To determine whether granulocyte-colony stimulating factor and erythropoietin are effective in the therapy of neutropenia and anaemia related to human immunodeficiency virus (HIV) infection and to anti-retroviral agents, we recruited 11 HIV-infected children (mean age 4 years 10 months). All the children were given gr
[Chemical condoms supposed to prevent HIV infection (news)]: Geburtshilfe Frauenheilkd. 1996 Mar;56(3):XVI-XVII. Unique Identifier : AIDSLINE MED/96230646
FK506 inhibits human lymphocyte migration and the production of lymphocyte chemotactic factors in liver allograft recipients.: Hepatology. 1996 Jun;23(6):1476-83. Unique Identifier : AIDSLINE MED/96243169; Adams DH; Liu Q; The Liver Unit Laboratories, Queen Elizabeth Hospital, Edgbaston,; Birmingham, England.; The macroglide immunosuppressant FK506 is effective at preventing and reversing hepatic allograft rejection. The establishment of graft rejection is dependent upon an influx of lymphocytes from the circulation into the graft in response to locally secreted chemotactic factors. Thus, inhibition of lymphocyte migration
Chimpanzee dendritic cells with potent immunostimulatory function can be propagated from peripheral blood.: Immunology. 1996 Apr;87(4):528-34. Unique Identifier : AIDSLINE MED/96256134; Barratt-Boyes SM; Henderson RA; Finn OJ; Department of Molecular Genetics and Biochemistry, School of; Medicine, University of Pittsburgh, PA, USA.; We have established dendritic cell (DC) cultures from chimpanzee peripheral blood mononuclear cells (PBMC) by using recombinant human (rh) granulocyte-macrophage colony-stimulating factor (GM-CSF) and rh interleukin-4 (IL-4) and demonstrate that these cells have all the characteristics of DC as described for other spe
HIV-1 upregulates Fas ligand expression in CD4+ T cells in vitro and in vivo: association with Fas-mediated apoptosis and modulation by aurintricarboxylic acid.: Immunology. 1996 Apr;87(4):581-5. Unique Identifier : AIDSLINE MED/96256141; Mitra D; Steiner M; Lynch DH; Staiano-Coico L; Laurence J; Laboratory for AIDS Virus Research, Cornell University Medical; College, New York 10021, NY, USA.; CD4+ T-lymphocyte apoptosis has been associated with human immunodeficiency virus (HIV)-1 infection in vitro, paralleling the expression of Fas (APO-1, CD95) on peripheral blood mononuclear cells from patients with HIV disease. However, the link between Fas induction, T-cell activation, and cell death is unclear. We d
Cytokines and cell surface markers in prediction of cardiac allograft rejection.: Immunol Invest. 1996 Jan-Mar;25(1-2):13-21. Unique Identifier : AIDSLINE MED/96262585; Chang DM; Ding YA; Kuo SY; Chang ML; Wei J; Division of Rheumatology/Immunology/Allergy, Tri-Service General; Hospital, National Defense Medical Center, Taipei, Taiwan, R.O.C.; Endomyocardial biopsy is generally used to quantify heart allograft rejection and guide immunotherapy. Biopsy, however, is invasive, costly, and risky. Since rejection requires lymphocyte activation, the purpose of this study was to assess alternative methods to evaluate rejection dynamics by investigating serum level
Lipoteichoic acid preparations of gram-positive bacteria induce interleukin-12 through a CD14-dependent pathway.: Infect Immun. 1996 Jun;64(6):1906-12. Unique Identifier : AIDSLINE MED/96238996; Cleveland MG; Gorham JD; Murphy TL; Tuomanen E; Murphy KM; Division of Dermatology, Department of Internal Medicine,; Washington University School of Medicine, St. Louis, Missouri; 63110, USA.; Interleukin 12 (IL-12) strongly augments gamma interferon production by natural killer (NK) and T cells. IL-12 also promotes effective cell-mediated immune responses, which are particularly important against intracellular bacteria such as Listeria monocytogenes. While the lipopolysaccharide (LPS) of gram-negative bact
In vitro simulation of immunosuppression caused by Trypanosoma brucei: active involvement of gamma interferon and tumor necrosis factor in the pathway of suppression.: Infect Immun. 1996 Jun;64(6):1937-43. Unique Identifier : AIDSLINE MED/96239000; Darji A; Beschin A; Sileghem M; Heremans H; Brys L; De Baetselier P; Unit of Cellular Immunology, Flemish Interuniversity Institute of; Biotechnology, University of Brussels (V.U.B.), Sint Genesius; Rode, Belgium.; Experimental infections of mice with the African trypanosome Trypanosoma brucei lead to a profound state of T-cell unresponsiveness in the lymph node cell (LNC) compartment. This suppression is mediated by macrophage-like cells which inhibit interleukin 2 ( IL-2 ) secret
CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins.: J Biol Chem. 1996 May 31;271(22):12852-8. Unique Identifier : AIDSLINE MED/96278675; Gedrich RW; Gilfillan MC; Duckett CS; Van Dongen JL; Thompson CB; Gwen Knapp Center for Lupus and Immunology Research, University; of Chicago, Chicago, Illinois 60637, USA.; CD30 is a member of the tumor necrosis factor (TNF) receptor family of proteins. CD30 can regulate proliferation of lymphocytes and may also play an important role in human immunodeficiency virus replication. However, little is known about CD30 signal transduction. We performed a yeast two-hybrid library screen with t
Sp1 family proteins recognize the U5 repressive element of the long terminal repeat of human T cell leukemia virus type I through binding to the CACCC core motif.: J Biol Chem. 1996 May 31;271(22):12944-50. Unique Identifier : AIDSLINE MED/96278690; Okumura K; Sakaguchi G; Takagi S; Naito K; Mimori T; Igarashi H; Shionogi Institute for Medical Science, 2-5-1 Mishima, Settsu,; Osaka 566, Japan.; We have identified several nuclear proteins binding to the U5 repressive element (U5RE) at the U5 region of the human T cell leukemia virus type I (HTLV-I) long terminal repeat (LTR). In gel mobility shift assays with the U5RE DNA probe, Jurkat T cell nuclear proteins generated five different complexes, named U5RE bin
MEK kinase is involved in tumor necrosis factor alpha-induced NF-kappaB activation and degradation of IkappaB-alpha.: J Biol Chem. 1996 May 31;271(22):13234-8. Unique Identifier : AIDSLINE MED/96278732; Hirano M; Osada S; Aoki T; Hirai S; Hosaka M; Inoue J; Ohno S; Department of Molecular Biology, Yokohama City University School; of Medicine, 3-9 Fuku-ura, Kanazawa-ku, Yokohama 236, Japan.; Signal-dependent activation of the transcription factor NF-kappaB is dominantly regulated by degradation of IkappaB-alpha protein. However, the signaling pathways that lead to the degradation are not clear. Here we report that mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) kinase,
Stroke in a young woman with a history of gonorrhea.: Hosp Pract (Off Ed). 1996 Jun 15;31(6):140-2. Unique Identifier : AIDSLINE MED/96281864; Solis ST; Ebright JR; Department of Internal Medicine, Wayne State University School of; Medicine, USA.
Glucocorticoids and interferon-alpha in the acquired immunodeficiency syndrome.: J Clin Endocrinol Metab. 1996 Jul;81(7):2601-6. Unique Identifier : AIDSLINE MED/96272884; Norbiato G; Bevilacqua M; Vago T; Clerici M; Department of Endocrinology, University Hospital L. Sacco; (Vialba), Milan, Italy.; Some patients with acquired immunodeficiency syndrome (AIDS) develop glucocorticoid resistance characterized by low receptor affinity (Kd) for glucocorticoids in mononuclear, cells and high values of ACTH and cortisol. As glucocorticoids regulate interferon-alpha (IFN alpha) production, we hypothesized that IFN alpha,
Human natural killer cells produce abundant macrophage inflammatory protein-1 alpha in response to monocyte-derived cytokines.: J Clin Invest. 1996 Jun 15;97(12):2722-7. Unique Identifier : AIDSLINE MED/96259518; Bluman EM; Bartynski KJ; Avalos BR; Caligiuri MA; Department of Hematologic Oncology, Roswell Park Cancer; Institute, Buffalo, New York 14263, USA.; Once infected by obligate intracellular pathogens, monocytes/macrophages release cytokines that activate natural killer (NK) cells. NK cells in turn produce and secrete monocyte/macrophage activating factors such as interferongamma (IFN-gamma), which are important in the early control of these infections. Here we demo
Transcription of human herpesvirus-like agent (HHV-8) in Kaposi's sarcoma.: J Clin Invest. 1996 Jun 15;97(12):2803-6. Unique Identifier : AIDSLINE MED/96259527; Huang YQ; Li JJ; Zhang WG; Feiner D; Friedman-Kien AE; Department of Dermatology, New York University Medical Center,; New York 10016, USA.; Recently, DNA sequences of what appear to be a unique human herpesvirus-like agent (HHV-8) have been detected in different types of Kaposi s sarcoma (KS) tumors (Chang, Y., E.C. Cesarman, M.S. Pessin, F. Lee, J.C. Culpepper, D.M. Knowles, and P.S. Moore. 1994. Science (Wash. DC). 266:1865-1869). To further elucidate t
Living with haemophilia and HIV/AIDS: support and coping.: J Adv Nurs. 1995 Dec;22(6):1101-11. Unique Identifier : AIDSLINE MED/96245715; Stewart MJ; Hart G; Mann KV; School of Nursing, Dalhousie University, Halifax, Nova Scotia,; Canada.; This paper describes sources and types of support, appraisal of support, and use of social support as a strategy for coping with Acquired Immune Deficiency Syndrome (AIDS)-related stresses. Thirty people with haemophilia, 23 family caregivers and 17 bereaved relatives participated. The study was conducted in two stage
NMR study of dideoxynucleotides with anti-human immunodeficiency virus (HIV) activity.: J Biochem Biophys Methods. 1996 Feb 5;31(3-4):113-21. Unique Identifier : AIDSLINE MED/96280087; Reddy DV; Jagannadh B; Kunwar AC; Indian Institute of Chemical Technology, Hyderabad, India.; The molecular structures of 3 -azido-2 ,3 -dideoxyribosylthymine 5 -triphosphate (AZTTP), 2 ,3 -dideoxyribosylinosine 5 -triphosphate (ddlTP), 3 -azido-2 ,3 -dideoxyribosylthymine 5 -monophosphate (AZTMP) and 2 ,3 -dideoxyribosyladenine 5 -monophosphate (ddAMP) have been studied by NMR to understand their anti-HIV act
Reduction of otherwise remarkably stable virus-specific cytotoxic T lymphocyte memory by heterologous viral infections.: J Exp Med. 1996 Jun 1;183(6):2489-99. Unique Identifier : AIDSLINE MED/96281900; Selin LK; Vergilis K; Welsh RM; Nahill SR; Department of Pathology, University of Massachusetts Medical; Center, Worcester 01655, USA.; Experimental analyses of the acute cytotoxic T lymphocyte (CTL) response to viruses have focused on studying these infections in immunologically naive hosts. In the natural environment, however, viral CTL responses occur in hosts that are already immune to other infectious agents. To address which factors contribute t
Autoreactive cytotoxic T lymphocytes in human immunodeficiency virus type 1-infected subjects.: J Exp Med. 1996 Jun 1;183(6):2509-16. Unique Identifier : AIDSLINE MED/96281902; di Marzo Veronese F; Arnott D; Barnaba V; Loftus DJ; Sakaguchi K; Thompson CB; Salemi S; Mastroianni C; Sette A; Shabanowitz J; Hunt DF; Appella E; Laboratory of Tumor Cell Biology, National Institutes of Health,; Bethesda, Maryland 20892, USA.; A subtractive analysis of peptides eluted from major histocompatibility complex (MHC) class I human histocompatibility leukocyte antigen (HLA)-A2.1 molecules purified from either human immunodeficiency virus type-1 (HIV-1)-infected or uninfected cells was performed using micro high-performance liquid chromatography an
Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10.: J Exp Med. 1996 Jun 1;183(6):2559-69. Unique Identifier : AIDSLINE MED/96281908; Gerosa F; Paganin C; Peritt D; Paiola F; Scupoli MT; Aste-Amezaga M; Frank I; Trinchieri G; Immunology and Infectious Disease Institute, University of; Verona, Italy.; Interleukin-12 (IL-12) induces differentiation of T helper 1 (Th1) cells, primarily through its ability to prime T cells for high interferon-gamma (IFN-gamma) production. We now report that the presence of IL-12 during the first several days of in vitro clonal expansion in limiting dilution cultures of polyclonally st
Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance.: J Exp Med. 1996 Jun 1;183(6):2605-16. Unique Identifier : AIDSLINE MED/96281912; Neurath MF; Fuss I; Kelsall BL; Presky DH; Waegell W; Strober W; Mucosal Immunity Section, National Institutes of Health,; NIH/NIAID/LCI, Bethesda, Maryland 20892-1890, USA.; In previous studies we showed that a chronic colitis associated with a Th1 T cell response can be induced by the rectal administration of the haptenizing reagent 2,4,6-trinitrobenzene sulfonic acid (TNBS). We report here that oral administration of haptenized colonic proteins (HCP) before rectal administration of TNBS
A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.: J Exp Med. 1996 Jun 1;183(6):2669-74. Unique Identifier : AIDSLINE MED/96281919; Powrie F; Carlino J; Leach MW; Mauze S; Coffman RL; DNAX Research Institute of Molecular and Cellular Biology Inc.,; Palo Alto 94304, USA.; A T helper type 1 (Th1)-mediated colitis with similarities to inflammatory bowel disease in humans developed in severe combined immunodeficiency mice reconstituted with CD45RB(high) CD4+ splenic T cells and could be prevented by cotransfer of CD45RB(low) CD4+ T cells. Inhibition of this Th1 response by the CD45RB(low)
Periodontal disease in HIV seropositive patients and its relation to lymphocyte subsets.: J Periodontol. 1996 Jan;67(1):33-6. Unique Identifier : AIDSLINE MED/96231184; Martinez-Canut P; Guarinos J; Bagan JV; Division of Periodontics, Facultad de Medicina y Odontologia,; Valencia, Spain.; This study was performed to determine the type of periodontal pathology found in a group of HIV+ patients and its relation to serum levels of CD4. The sample consisted of 101 individuals: intravenous drug users (84%), homosexuals (7%), and heterosexuals (10%). Each patient was examined clinically and radiographically.
All that palsies is not Bell's.: J R Soc Med. 1996 Apr;89(4):184-7. Unique Identifier : AIDSLINE MED/96255832; James DG; Royal Free Hospital, Pond Street, London, England.
Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents.: J Med Chem. 1996 Mar 1;39(5):1016-7. Unique Identifier : AIDSLINE MED/96241537; Kashiwada Y; Hashimoto F; Cosentino LM; Chen CH; Garrett PE; Lee KH; Natural Products Laboratory, Division of Medicinal Chemistry and; Natural Products, School of Pharmacy, University of North; Carolina at Chapel Hill, 27599, USA.
Betulinic acid derivatives: a new class of human immunodeficiency virus type 1 specific inhibitors with a new mode of action.: J Med Chem. 1996 Mar 1;39(5):1056-68. Unique Identifier : AIDSLINE MED/96241544; Evers M; Poujade C; Soler F; Ribeill Y; James C; Lelievre Y; Gueguen JC; Reisdorf D; Morize I; Pauwels R; De Clercq E; Henin Y; Bousseau A; Mayaux JF; Le Pecq JB; Dereu N; Rhone-Poulenc Rorer S.A., Centre de Recherche de; Vitry-Alfortville, Vitry sur Seine, France.; A series of omega-undecanoic amides of lup-20(29)-en-28-oic acid derivatives were synthesized and evaluated for activity in CEM 4 and MT-4 cell cultures against human immunodeficiency virus type 1 (HIV-1) strain IIIB/LAI. The potent HIV inhibitors which emerged, compounds 5a, 16a, and 17b, were all derivatives of betu
Betulinic acid derivatives: a new class of specific inhibitors of human immunodeficiency virus type 1 entry.: J Med Chem. 1996 Mar 1;39(5):1069-83. Unique Identifier : AIDSLINE MED/96241545; Soler F; Poujade C; Evers M; Carry JC; Henin Y; Bousseau A; Huet T; Pauwels R; De Clercq E; Mayaux JF; Le Pecq JB; Dereu N; Rhone-Poulenc Rorer, Centre de Recherche de Vitry-Alfortville,; Vitry sur Seine, France.; A novel series of omega-aminoalkanoic acid derivatives of betulinic acid were synthesized and evaluated for their activity against human immunodeficiency virus (HIV). The anti-HIV-1 activity of several members of this new series was found to be in the nanomolar range in CEM 4 and MT-4 cell cultures. The optimization o
Synthesis and biological evaluation of1',2'-seconucleo-5'- phosphonates.: J Med Chem. 1996 Mar 1;39(5):1130-5. Unique Identifier : AIDSLINE MED/96241552; Racha S; Vargeese C; Vemishetti P; El-Subbagh HI; Abushanab E; Panzica RP; Department of Medicinal Chemistry, University of Rhode Island,; Kingston, Rhode Island 02881, USA.; A series of 1 ,2 -seconucleophosphonate analogues were prepared containing adenine, cytosine, thymine, and uracil as the nucleobase. The synthetic methodology is efficient and uses chloromethyl ethers derived from the chirons diethyl (3S)-(benzyloxy)-(2R)-hydroxybutane-phosphonate (1) and diethyl (3S),4-bis(benzyloxy)
[World AIDS year: final declaration]: J Med Liban. 1995;43(1):43-4. Unique Identifier : AIDSLINE MED/96271875
Cyclophilin A is required for the replication of group M human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus SIV(CPZ)GAB but not group O HIV-1 or other primate immunodeficiency viruses.: J Virol. 1996 Jul;70(7):4220-7. Unique Identifier : AIDSLINE GENBANK/U53175; Braaten D; Franke EK; Luban J; Department of Microbiology, Columbia University College of; Physicians and Surgeons, New York, New York 10032, USA.; The human immunodeficiency virus type 1 (HIV-1) Gag polyprotein binds to cyclophilin A and incorporates this cellular peptidyl prolyl-isomerase into virions. Disruption of cyclophilin A incorporation, either by gag mutations or by cyclosporine A, inhibits virion infectivity, indicating that cyclophilin A plays an esse
Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein.: J Virol. 1996 Jul;70(7):4283-90. Unique Identifier : AIDSLINE MED/96256736; Pandori MW; Fitch NJ; Craig HM; Richman DD; Spina CA; Guatelli JC; Department of Medicine, University of California San Diego School; of Medicine, California 92093-0619, USA.; Type 1 human immunodeficiency viruses encoding mutated nef reading frames are 10- to 30-fold less infectious than are isogenic viruses in which the nef gene is intact. This defect in infectivity causes nef-negative viruses to grow at an attenuated rate in vitro. To investigate the mechanism of Nef-mediated enhancement
Binding of the human immunodeficiency virus type 1 Gag polyprotein to cyclophilin A is mediated by the central region of capsid and requires Gag dimerization.: J Virol. 1996 Jul;70(7):4299-310. Unique Identifier : AIDSLINE MED/96256738; Colgan J; Yuan HE; Franke EK; Luban J; Department of Microbiology, College of Physicians and Surgeons of; Columbia University, New York, New York 10032USA.; The cellular peptidyl-prolyl isomerase cyclophilin A (CyPA) is incorporated into human immunodeficiency virus type 1 (HIV-1) virions via direct contacts with the HIV-1 Gag polyprotein. Disruption of the Gag-CyPA interaction leads to the production of HIV-1 particles lacking CyPA; these virions are noninfectious, indic
Therapeutic effect of Gag-nuclease fusion protein on retrovirus-infected cell cultures.: J Virol. 1996 Jul;70(7):4329-37. Unique Identifier : AIDSLINE MED/96256741; Schumann G; Qin L; Rein A; Natsoulis G; Boeke JD; Department of Molecular Biology and Genetics, Johns Hopkins; University School of Medicine, Baltimore, Maryland 21205, USA.; Capsid-targeted viral inactivation is a novel protein-based strategy for the treatment of viral infections. Virus particles are inactivated by targeting toxic fusion proteins to virions, where they destroy viral components from within. We have fused Staphylococcus nuclease (SN) to the C-terminal end of Moloney murine
Transduction of human CD34+ hematopoietic progenitor cells by a retroviral vector expressing an RRE decoy inhibits human immunodeficiency virus type 1 replication in myelomonocytic cells produced in long-term culture.: J Virol. 1996 Jul;70(7):4352-60. Unique Identifier : AIDSLINE MED/96256744; Bahner I; Kearns K; Hao QL; Smogorzewska EM; Kohn DB; Department of Pediatrics, University of Southern California; School of Medicine, California 90027, USA.; Genetic modification of hematopoietic stem cells with a synthetic anti-human immunodeficiency virus type 1 (HIV-1) gene which inhibits replication of HIV-1 may allow production of mature lymphoid and monocytic cells resistant to HIV-1 growth after autologous transplantation. Because productive HIV-1 replication requir
Resistance of previously infected chimpanzees to successive challenges with a heterologous intraclade B strain of human immunodeficiency virus type 1.: J Virol. 1996 Jul;70(7):4361-9. Unique Identifier : AIDSLINE MED/96256745; Shibata R; Seimon C; Cho MW; Arthur LO; Nigida SM Jr; Matthews T; Sawyer LA; Schultz A; Murthy KK; Israel Z; Javadian A; Frost P; Kennedy RC; Lane HC; Martin MA; Laboratory of Molecular Microbiology, Division of AIDS, National; Institute of Allergy and Infectious Diseases, Bethesda, Maryland,; USA.; To test whether the protective effects of attenuated simian immunodeficiency virus vaccines in macaques were applicable to the human immunodeficiency virus type 1 (HIV-1)-chimpanzee system, two groups of animals, previously infected with HIV-1(IIIB) or HIV-1(SF2) were each challenged with a heterologous clade B virus,
TM domain swapping of murine leukemia virus and human T-cell leukemia virus envelopes confers different infectious abilities despite similar incorporation into virions.: J Virol. 1996 Jul;70(7):4380-6. Unique Identifier : AIDSLINE MED/96256747; Denesvre C; Carrington C; Corbin A; Takeuchi Y; Cosset FL; Schulz T; Sitbon M; Sonigo P; Genetique des Virus, ICGM-CNRS UPR415, Institut Cochin de; GenetiqueMoleculaire, France.; We investigated the influence of transmembrane protein (TM) domains on incorporation of retroviral envelopes into virions and on infectivity. We introduced complete, truncated, or chimeric Friend murine leukemia virus (F-MuLV) and human T-cell leukemia virus type 1 (HTLV-1) envelopes into an MuLV particle-producing co
In vivo blockade of gamma interferon affects the influenza virus-induced humoral and the local cellular immune response in lung tissue.: J Virol. 1996 Jul;70(7):4411-8. Unique Identifier : AIDSLINE MED/96256750; Baumgarth N; Kelso A; Cooperative Research Center for Vaccine Technology and; Transplantation Biology Unit, Queensland Institute of Medical; Research, Brisbane, Queensland, Australia. nicoleB@qimr.edu.au; Influenza virus infection induces the local production of gamma interferon (IFN-gamma) by T cells and non-T cells in the respiratory tract. To elucidate the possible functions of this cytokine, the humoral and local cellular immune responses to influenza virus were studied in BALB/c mice with or without in vivo neutra
Activation of transcription factor NF-kappaB by the Tat protein of human immunodeficiency virus type 1.: J Virol. 1996 Jul;70(7):4427-37. Unique Identifier : AIDSLINE MED/96256752; Demarchi F; d'Adda di Fagagna F; Falaschi A; Giacca M; International Centre for Genetic Engineering and Biotechnology,; Trieste, Italy.; A recombinant Tat protein was used to investigate the molecular mechanisms of transcriptional activation of the human immunodeficiency virus type 1 long terminal repeat (LTR). Liposome-mediated delivery of this protein to responsive cells results in dose-dependent LTR activation. As evaluated by mRNA quantitation with
A role for urokinase-type plasminogen activator in human immunodeficiency virus type 1 infection of macrophages.: J Virol. 1996 Jul;70(7):4451-6. Unique Identifier : AIDSLINE MED/96256755; Handley MA; Steigbigel RT; Morrison SA; Department of Pharmacology, University Medical Center at Stony; Brook, Stony Brook, New York, USA.; Urokinase-type plasminogen activator (uPA), a proteinase which activates plasminogen by cleaving at -CPGR(arrow downward)V-, was shown to cleave the V3 loop in recombinant gp120 of human immunodeficiency virus type 1 (HIV-1) IIIB and MN strains, as well as a synthetic, cyclized peptide representing the clade B consens
Synergistic neutralization of human immunodeficiency virus type 1 by a chimpanzee monoclonal antibody against the V2 domain of gp120 in combination with monoclonal antibodies against the V3 loop and the CD4-binding site.: J Virol. 1996 Jul;70(7):4466-73. Unique Identifier : AIDSLINE MED/96256757; Vijh-Warrier S; Pinter A; Honnen WJ; Tilley SA; Public Health Research Institute, New York, New York 10016, USA.; Synergistic neutralization of human immunodeficiency virus type 1 (HIV-1) was observed in studies using a chimpanzee anti-V2 monoclonal antibody (MAb), C108G, in combination with anti-V3 loop and anti-CD4 binding-site (bs) MAbs of different epitope specificities. C108G paired with either of two anti-V3 loop MAbs or ei
Characterization of human immunodeficiency virus type 1 p17 matrix protein motifs associated with mother-to-child transmission.: J Virol. 1996 Jul;70(7):4474-83. Unique Identifier : AIDSLINE MED/96256758; Narwa R; Roques P; Courpotin C; Parnet-Mathieu F; Boussin F; Roane A; Marce D; Lasfargues G; Dormont D; Service de Neurovirologie, Departement de Recherche Medicale,; Direction des Sciences du Vivant, Service de Sante des Armees,; Commissariat a l'Energie Atomique, France.; In order to determine if viral selection occurs during mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1), we used a direct solid-phase sequencing method to sequence the p17 matrix protein-encoding regions of viral isolates from 12 HIV-1-infected mother-and-child pairs, 4 infected infants, 4 t
Inhibition of human immunodeficiency virus type 1 integrase by the Fab fragment of a specific monoclonal antibody suggests that different multimerization states are required for different enzymatic functions.: J Virol. 1996 Jul;70(7):4484-94. Unique Identifier : AIDSLINE MED/96256759; Barsov EV; Huber WE; Marcotrigiano J; Clark PK; Clark AD; Arnold E; Hughes SH; ABL-Basic Research Program, NCI-Frederick Cancer Research and; Development Center, Frederick, Maryland 21702-1201, USA.; We have characterized a murine monoclonal antibody (MAb 35), which was raised against human immunodeficiency virus type 1 (HIV-1) integration protein (IN), and the corresponding Fab 35. Although MAb 35 does not inhibit HIV-1 IN, Fab 35 does. MAb 35 (and Fab 35) binds to an epitope in the C-terminal region of HIV-1 IN.
Alpha/beta interferons increase host resistance to murine AIDS.: J Virol. 1996 Jul;70(7):4517-22. Unique Identifier : AIDSLINE MED/96256763; Heng JK; Price P; Lai CM; Beilharz MW; Department of Microbiology, Queen Elizabeth II Medical Centre,; University of Western Australia, Australia.; Murine AIDS (MAIDS) is caused by a defective retrovirus present in the LP-BM5 murine leukemia virus mixture. Strains of inbred mice differ in resistance to MAIDS development; some are susceptible (e.g., C57BL/6), while others are resistant (e.g., CBA and B10.BR). As an early block to viral replication in resistant mic
Inducible human immunodeficiency virus type 1 packaging cell lines.: J Virol. 1996 Jul;70(7):4530-7. Unique Identifier : AIDSLINE MED/96256765; Yu H; Rabson AB; Kaul M; Ron Y; Dougherty JP; Department of Molecular Genetics and Microbiology, Robert Wood; Johnson Medical School, University of Medicine and Dentistry of; New Jersey, Piscataway, New Jersey 08854-5635, USA.; Packaging cell lines are important tools for transferring genes into eukaryotic cells. Human immunodeficiency virus type 1 (HIV-1)-based packaging cell lines are difficult to obtain, in part owing to the problem that some HIV-1 proteins are cytotoxic in a variety of cells. To overcome this, we have developed an HIV-1-
The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function.: J Virol. 1996 Jul;70(7):4576-84. Unique Identifier : AIDSLINE MED/96256770; Yang X; Herrmann CH; Rice AP; Division of Molecular Virology, Baylor College of Medicine,; Houston, Texas 77030, USA.; Human immunodeficiency virus types 1 and 2 encode closely related proteins, Tat-1 and Tat-2, that stimulate viral transcription. Previously, we showed that the activation domains of these proteins specifically interact in vitro with a cellular protein kinase named TAK. In vitro, TAK phosphorylates the Tat-2 but not th
Location, exposure, and conservation of neutralizing and nonneutralizing epitopes on human immunodeficiency virus type 2 SU glycoprotein.: J Virol. 1996 Jul;70(7):4598-606. Unique Identifier : AIDSLINE MED/96256772; McKnight A; Shotton C; Cordell J; Jones I; Simmons G; Clapham PR; Virology Laboratory, Chester Beatty Laboratories, The Institute; of Cancer Research, London, United Kingdom.; Eleven rat monoclonal antibodies (MAbs) that recognize the SU glycoprotein of human immunodeficiency virus type 2 (HIV-2) ROD were produced and characterized. Binding sites for eight of these MAbs were mapped to epitopes within the Cl, V1/V2, C2, and V3 envelope regions. The three other MAbs defined at least two confo
bc1-2 expression facilitates human immunodeficiency virus type-1 mediated cytopathic effects during acute spreading infections.: J Virol. 1996 Jul;70(7):4617-22. Unique Identifier : AIDSLINE MED/96256774; Sandstrom PA; Pardi D; Goldsmith CS; Chengying D; Diamond AM; Folks TM; Retrovirus Diseases Branch, Division of Viral and Rickettsial; Diseases,National Center for Infectious Diseases, Centers for; Disease Control and Prevention, Atlanta, Georgia 30333, USA.; The cytopathic effects (CPE) resulting from the infection of CD4+ T cells by human immunodeficiency virus (HIV) have generally been characterized as single-cell killing associated with apoptosis and/or the generation of syncytia resulting from the direct cell-to-cell transmission of the virus. Little is known, however
cis-acting elements in human immunodeficiency virus type 1 RNAs direct viral transcripts to distinct intranuclear locations.: J Virol. 1996 Jul;70(7):4667-82. Unique Identifier : AIDSLINE MED/96256779; Berthold E; Maldarelli F; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA.; Two distinct intranuclear locations were identified for alternatively spliced RNA transcripts expressed from the pNL4-3 infectious molecular clone of human immunodeficiency virus (HIV) type 1. Multiply spliced HIV RNA encoding tat was detected within the nucleus in large clusters; immunostaining and colocalization stu
Effects of modifying the tRNA(3Lys) anticodon on the initiation of human immunodeficiency virus type 1 reverse transcription.: J Virol. 1996 Jul;70(7):4700-6. Unique Identifier : AIDSLINE MED/96256782; Huang Y; Shalom A; Li Z; Wang J; Mak J; Wainberg MA; Kleiman L; Lady Davis Institute for Medical Research and McGill AIDS Centre,; McGill University, Montreal, Quebec, Canada.; tRNA(3Lys) is a primer for reverse transcription in human immunodeficiency virus type 1 (HIV-1), and the anticodon of tRNA(3Lys) has been implicated in playing a role in both its placement onto the HIV-1 genome and its interaction with HIV-1 reverse transcriptase (RT). In this work, the anticodon in a tRNA(3Lys) gene
Two separate envelope regions influence induction of brain disease by a polytropic murine retrovirus (FMCF98).: J Virol. 1996 Jul;70(7):4825-8. Unique Identifier : AIDSLINE MED/96256802; Hasenkrug KJ; Robertson SJ; Porti J; McAtee F; Nishio J; Chesebro B; Laboratory of Persistent Viral Diseases, Rocky Mountain; Laboratories, National Institute of Allergy and Infectious; Diseases, Hamilton, Montana 59840, USA. Kim; Hasenkrug@rml.niaid.pc.niaid.nih.gov; The major determinants involved in neurological disease induction by polytropic murine leukemia virus FMCF98 are encoded by the envelope gene. To map these determinants further, we produced four chimeras which contained neurovirulent FMCF98 envelope sequences combined with envelope sequences from the closely related n
Increased polymerase fidelity of E89G, a nucleoside analog-resistant variant of human immunodeficiency virus type 1 reverse transcriptase.: J Virol. 1996 Jul;70(7):4834-8. Unique Identifier : AIDSLINE MED/96256804; Drosopoulos WC; Prasad VR; Department of Microbiology and Immunology, Albert Einstein; College of Medicine, Bronx, New York 10461, USA.; Nucleoside analog resistance in human immunodeficiency virus type 1 results from mutations in reverse transcriptase (RT) that allow the enzyme to discriminate against such analogs. To evaluate the possible impact of such mutations on the ability of human immunodeficiency virus RT to selectively incorporate Watson-Cric
Inhibition of human immunodeficiency virus type 1 replication is enhanced by a combination of transdominant Tat and Rev proteins.: J Virol. 1996 Jul;70(7):4871-6. Unique Identifier : AIDSLINE MED/96256811; Ulich C; Harrich D; Estes P; Gaynor RB; Division of Molecular Virology, Department of Medicine,; University of Texas Southwestern Medical Center at Dallas, Texas; 75235-8594, USA.; Mutation of either of two critical human immunodeficiency virus type 1 (HIV-1) regulatory proteins, Tat and Rev, results in marked defects in viral replication. Thus, inhibition of the function of one or both of these proteins can significantly inhibit viral growth. In the present study, we constructed a novel transdo
Megestrol acetate in patients with AIDS-related cachexia.: JPEN J Parenter Enteral Nutr. 1996 Mar-Apr;20(2):165-6. Unique Identifier : AIDSLINE MED/96255122; Bell SJ; Hestnes JC; Wanke C; Forse RA
[A case of AIDS with bronchial tuberculosis]: Kekkaku. 1996 May;71(5):345-9. Unique Identifier : AIDSLINE MED/96276902; Naganuma M; Toyoda T; Osumi M; Kanno I; Takasugi T; Kawashiro T; Aoyagi T; Fukuda J; Division of Respiratory Disease, National Higasi-Saitama; Hospital, Japan.; A case is 48 years-old Japanese man who had a history of frequent sexual contact with prostitutes in Thailand and the Philippines . He presented with chief complaint of chest discomfort in April 1995. His chest X-ray film showed right medi
AIDS and the lung.: Med Clin North Am. 1996 Jul;80(4):775-801. Unique Identifier : AIDSLINE MED/96313912; Huang L; Stansell JD; Division of Pulmonary and Critical Care Medicine, San Francisco; General Hospital, CA 94110, USA.; Respiratory symptoms are common in HIV-infected persons. The challenge facing clinicians is to determine whether these respiratory symptoms are due to an opportunistic infection or to a chronic process, such as asthma, chronic bronchitis, bronchiectasis, or emphysema. This article reviewed the clinical presentation, d
US approves home HIV test [news]: Lancet. 1996 May 25;347(9013):1472. Unique Identifier : AIDSLINE MED/96225361; Barnett AA
Diverse HIV-1 genetic subtypes in UK [letter]: Lancet. 1996 May 25;347(9013):1487. Unique Identifier : AIDSLINE MED/96225381; Clewley JP; Arnold C; Barlow KL; Grant PR; Parry JV
Hepatitis E antibodies and HIV status [letter]: Lancet. 1996 May 25;347(9013):1494. Unique Identifier : AIDSLINE MED/96225395; Bissuel F; Houhou N; Leport C; Brun-Vezinet F; Vilde JL
Vancouver AIDS meeting highlights combination attack on HIV [news]: Lancet. 1996 Jul 13;348(9020):115. Unique Identifier : AIDSLINE MED/96294525; Sharp D
HIV-1 group O infection identified in USA [news]: Lancet. 1996 Jul 13;348(9020):116. Unique Identifier : AIDSLINE MED/96294526; Rowe PM
Global burden of the HIV pandemic.: Lancet. 1996 Jul 13;348(9020):99-106. Unique Identifier : AIDSLINE MED/96294521; Quinn TC; National Institute of Allergy and Infectious Diseases, Baltimore,; Maryland, USA.; Within the global pandemic of HIV infection there are many different epidemics, each with its own dynamics and each influenced by many factors including time of introduction of the virus, population density, and cultural and social issues. Effective management strategies depend on knowledge of all these factors. By th
Glutamine deficiency as a cause of human immunodeficiency virus wasting.: Med Hypotheses. 1996 Mar;46(3):252-6. Unique Identifier : AIDSLINE MED/96242213; Shabert JK; Wilmore DW; Brigham and Women's Hospital, Boston, MA 02115, USA.; Tissue wasting often occurs during human immunodeficiency virus infection and acquired immune deficiency syndrome. While weight-loss in the human immunodeficiency virus-infected individual can be seen as an isolated symptom, catabolism during acquired immune deficiency syndrome is usually associated with complications
Managing HIV. Part 6: People living with HIV. Medically acquired HIV infection.: Med J Aust. 1996 Jul 1;165(1):36-8. Unique Identifier : AIDSLINE MED/96292141; Garsia RJ; Ross J; Shipway P; Wylie B; Royal Prince Alfred Hospital, Sydney, NSW.; Often an underlying disorder (such as haemophilia) creates special management issues for people with medically acquired HIV. Although the risk of infection through donated biological materials is now slight, an unknown number of undiagnosed cases remain in the community.
Managing HIV. Part 6: People living with HIV. HIV and injecting drug use.: Med J Aust. 1996 Jul 1;165(1):39-40. Unique Identifier : AIDSLINE MED/96292142; Wodak A; van Beek I; Alcohol and Drug Service, St Vincent's Hospital, Sydney, NSW.; Injecting drug use can not only lead to HIV infection via the sharing of injecting equipment, it can also complicate the course and management of infection.
Managing HIV. Part 6: People living with HIV. HIV and isolated Aboriginal communities.: Med J Aust. 1996 Jul 1;165(1):41-2. Unique Identifier : AIDSLINE MED/96292143; Skov S; Bowden F; McCaul P; Thompson J; Scrimgeour D; Tri-State STD/HIV Project, Alice Springs, Australia.; Aboriginal communities and their health services should prepare together and in advance for caring for an HIV-infected person. Good social support will be the keystone to successful clinical management. Health care workers must look to Aboriginal people for the lead in developing appropriate responses.
Managing HIV. Part 6: People living with HIV. Travellers with HIV.: Med J Aust. 1996 Jul 1;165(1):43-5. Unique Identifier : AIDSLINE MED/96292144; Ruff TA; International Health Unit, Macfarlane Burnet Centre for Medical; Research, Melbourne, VIC.; Many HIV-infected people travel abroad, and although most can travel in relative safety there are a range of issues and risks to be considered by their medical advisers.
Is a syringe exchange feasible in a prison setting? [letter]: Med J Aust. 1996 Jul 1;165(1):59. Unique Identifier : AIDSLINE MED/96292146; Eyland SJ
Measles pneumonitis following measles-mumps-rubella vaccination of a patient with HIV infection, 1993.: MMWR Morb Mortal Wkly Rep. 1996 Jul 19;45(28):603-6. Unique Identifier : AIDSLINE MED/96312573; The Advisory Committee on Immunization Practices (ACIP) recommends measles-mumps-rubella vaccine (MMR) for all persons asymptomatically infected with human immunodeficiency virus (HIV) and recommends that MMR be considered for all symptomatic HIV-infected persons who would otherwise be eligible for measles vaccine, be
Recombinant human Fab antibody fragments to HIV-1 Rev and Tat regulatory proteins: direct selection from a combinatorial phage display library.: Mol Immunol. 1996 Mar-Apr;33(4-5):439-50. Unique Identifier : AIDSLINE GENBANK/U33321; Pilkington GR; Duan L; Zhu M; Keil W; Pomerantz RJ; Intracel Corporation, Cambridge, MA 02139, USA.; A human Fab phage display library has been produced from peripheral blood lymphocytes of an individual who was asymptomatic after 10 years of infection with human immunodeficiency virus type-1 (HIV-1). The library was panned against the HIV-1 Rev and Tat regulatory proteins and several clones, producing Fab binding to
A comparison of two regimens for the treatment of Mycobacterium avium complex bacteremia in AIDS: rifabutin, ethambutol, and clarithromycin versus rifampin, ethambutol, clofazimine, and ciprofloxacin. Canadian HIV Trials Network Protocol 010 Study Group [see comments]: N Engl J Med. 1996 Aug 8;335(6):377-83. Unique Identifier : AIDSLINE MED/96293367; Shafran SD; Singer J; Zarowny DP; Phillips P; Salit I; Walmsley SL; Fong IW; Gill MJ; Rachlis AR; Lalonde RG; Fanning MM; Tsoukas CM; Department of Medicine, University of Alberta, Edmonton, Canada.; BACKGROUND: Bacteremia with the Mycobacterium avium complex is common in patients with the acquired immunodeficiency syndrome (AIDS), but the most effective treatment for this infection remains unclear. METHODS: We randomly assigned 229 patients with AIDS and M. avium complex bacteremia to receive either rifampin (600
A randomized trial of clarithromycin as prophylaxis against disseminated Mycobacterium avium complex infection in patients with advanced acquired immunodeficiency syndrome [see comments]: N Engl J Med. 1996 Aug 8;335(6):384-91. Unique Identifier : AIDSLINE MED/96293368; Pierce M; Crampton S; Henry D; Heifets L; LaMarca A; Montecalvo M; Wormser GP; Jablonowski H; Jemsek J; Cynamon M; Yangco BG; Notario G; Craft JC; Vanderbilt University, Nashville, USA.; BACKGROUND: Disseminated infection with Mycobacterium avium complex is the most common opportunistic infection in patients with advanced stages of the acquired immunodeficiency syndrome (AIDS). We studied the efficacy and safety of prophylactic treatment with clarithromycin, a macrolide antibiotic. METHODS: We conduct
Prophylaxis against disseminated Mycobacterium avium complex with weekly azithromycin, daily rifabutin, or both. California Collaborative Treatment Group [see comments]: N Engl J Med. 1996 Aug 8;335(6):392-8. Unique Identifier : AIDSLINE MED/96293369; Havlir DV; Dube MP; Sattler FR; Forthal DN; Kemper CA; Dunne MW; Parenti DM; Lavelle JP; White ACJr; Witt MD; Bozzette SA; McCutchan JA; University of California, San Diego, CA, USA.; BACKGROUND: Azithromycin is active in treating Mycobacterium avium complex disease, but it has not been evaluated as primary prophylaxis in patients with human immunodeficiency virus (HIV) infection. Because the drug is concentrated in macrophages and has a long half-life in tissue, there is a rationale for once-weekl
Advances in the prevention and treatment of Mycobacterium avium disease [editorial; comment]: N Engl J Med. 1996 Aug 8;335(6):428-30. Unique Identifier : AIDSLINE MED/96293375; Horsburgh CR Jr
[Zidovudine-resistant HIV strains in intravenous drug users and homosexual men in Amsterdam]: Ned Tijdschr Geneeskd. 1996 Apr 27;140(17):932-4. Unique Identifier : AIDSLINE MED/96242809; de Ronde A; de Rooij ER; Coutinho RA; Goudsmit J; Afd. Humane Retrovirologie, Academisch Medisch Centrum,; Amsterdam.; OBJECTIVE: To investigate the spread of HIV strains resistant to antiviral drugs prescribed in the Netherlands . DESIGN: Descriptive. SETTING: Amsterdam. METHOD: In several cohorts of homosexual men and intravenous drug users being followed in Amsterdam, in cases of newly acqui
[Dementia-paranoid syndrome as the initial manifestation of AIDS. Case report and diagnostic overview]: Nervenarzt. 1996 Jan;67(1):68-71. Unique Identifier : AIDSLINE MED/96227640; Sobanski T; Assion HJ; Hoflich G; Scholl HP; Psychiatrische Klinik und Poliklinik, Universitat, Bonn.; A 33-year-old HIV-1-positive man developed dementia and a paranoid symptomatology with auditory hallucinations as the first manifestation of AIDS. The immunodeficiency syndrome is currently represented only by the immunohistochemical findings (CD4 216/microliters; CD4/CD8 ratio 0.1
[Arterial hypertension induced by erythropoietin]: Pol Arch Med Wewn. 1996 Feb;95(2):153-9. Unique Identifier : AIDSLINE MED/96282352; Lietz K; Koziak K; Gaciong Z; Centralnego Laboratorium PSK-1 oraz Instytutu Transplantologii; Akademii Medycznej w Warszawie.
[The role of the HTLV-I virus in transformation of T lymphocytes]: Postepy Hig Med Dosw. 1995;49(5):585-97. Unique Identifier : AIDSLINE MED/96254221; Papiez M; Zaklad Wirusologii Instytutu Mikrobiologii Collegium Medicum; Uniwersytetu Jagiellonskiego w Krakowie.; HTLV-I virus is as etiological agent of adult T-cell leukemia (ATL). The virus encodes Tax regulatory protein, which induces malignant transformation of the T lymphocytes. Tax increases the expression of cell protooncogenes as well as lymphokines, among others IL-2 and
Effectiveness of counseling in the health promotion of HIV-positive clients in the community.: Public Health Nurs. 1996 Jun;13(3):209-16. Unique Identifier : AIDSLINE MED/96268026; DiScenza S; Nies M; Jordan C; Adult Special Care Clinic, Regional Medical Center, Memphis,; Tennessee, USA.; The purpose of this study was to examine the effects of a nurse s counseling intervention on high-risk sexual behaviors of HIV-positive patients and to explore the relationship of gender, race, age, and education to high-risk sexual behaviors. A convenience sample of 20 adults who were newly diagnosed with HIV and wer
Latino women and AIDS risk.: Public Health Nurs. 1996 Jun;13(3):217-22. Unique Identifier : AIDSLINE MED/96268027; Peragallo N; Department of Public Health, Mental Health, and Administrative; Nursing, University of Illinois, Chicago College of Nursing; 60680-6998, USA.; This study describes risk behaviors among Puerto Rican women and identifies variables related to high-risk behavior, including sociodemographic status, knowledge about HIV and AIDS, religiosity, acculturation, and attitudes toward contraceptive use and homosexuality. Puerto Rican women (N = 121) were recruited through
HIV/AIDS report.: Proc Annu Meet Med Sect Am Counc Life Insur. 1995;:181-2. Unique Identifier : AIDSLINE MED/96315457; Gleeson RK
Diminished mammary gland lymphocyte functions parallel shifts in trafficking patterns during the postpartum period.: Proc Soc Exp Biol Med. 1996 Jul;212(3):271-80. Unique Identifier : AIDSLINE MED/96268355; Shafer-Weaver KA; Pighetti GM; Sordillo LM; Department of Veterinary Science, Pennsylvania State University,; University Park 16802, USA.; Once activated, lymphocytes can regulate both specific and nonspecific immune responses. Alterations in lymphocyte function may increase the host s vulnerability to bacterial infections such as mastitis. Susceptibility to mastitis as well as diminished leukocyte functional capabilities have been shown to be influenced
The gastrointestinal manifestations of pediatric AIDS.: Radiol Clin North Am. 1996 Jul;34(4):779-90. Unique Identifier : AIDSLINE MED/96291345; Stoane JM; Haller JO; Orentlicher RJ; Department of Radiology, State University of New York Health; Science Center at Brooklyn 11203-2098, USA.; The manifestations of AIDS in the gastrointestinal tract in children are mainly secondary to opportunistic infections and AIDS-related neoplasms. This article reviews the radiologic and pathologic findings seen throughout the gastrointestinal tract and within the abdomen in children afflicted with AIDS. Although many
[Pneumocystis carinii pneumonia in AIDS: retrospective analysis of 80 documented cases (1985-1993)]: Rev Med Interne. 1996;17(1):25-33. Unique Identifier : AIDSLINE MED/96238588; Morlat P; Bartou C; Ragnaud JM; Dequae L; Lacoste D; Buisson M; Bernard N; Mercie P; Couprie B; Beylot J; Aubertin J; Service de medecine interne, hopital Saint-Andre, Bordeaux,; France.; Eighty initial episodes of HIV-associated Pneumocystis carinii pneumonia (PCP) diagnosed at Bordeaux hospital between 1985 and 1993 are reported (57 were men and 23 women). PCP revealed HIV infection in 29 patients (36%). Others cases were patients with poor medical follow up (10%), with a CD4+ lymphocyte count above
[The role of aminoglycosides in HIV-infected patients]: Schweiz Med Wochenschr Suppl. 1996;76:49S-53S. Unique Identifier : AIDSLINE MED/96236353; Opravil M; Abteilung Infektionskrankheiten und Spitalhygiene,; Universitatsspital Zurich.; The frequency of serious infections due to Pseudomonas aeruginosa is increasing among patients with advanced HIV infection; most of the cases are community-acquired. Early diagnosis and adequate treatment--usually with the combination of an anti-pseudomonas beta-lactam antibiotic and an aminoglycoside--have a crucial
HIV quasispecies and resampling [letter; comment]: Science. 1996 Jul 26;273(5274):415-6. Unique Identifier : AIDSLINE MED/96310738; Liu SL; Rodrigo AG; Shankarappa R; Learn GH; Hsu L; Davidov O; Zhao LP; Mullins JI
Cerebral aneurysm in the HIV patient: a report of six cases.: Surg Neurol. 1996 Jul;46(1):49-54. Unique Identifier : AIDSLINE MED/96289997; Maniker AH; Hunt CD; Section of Neurosurgery, University of Medicine and Dentistry of; New Jersey, the New Jersey Medical School, Newark, New Jersey,; USA.; BACKGROUND: In view of the almost certain mortality of the acquired immune deficiency syndrome (AIDS) patient, controversy may arise as to how to treat those individuals with concomitant aneurysmal disease. METHODS: We conducted a retrospective case review of six patients seen in a 1-year period, who had a history of
Characterization of extrathymic T cells of chickens.: Vet Immunol Immunopathol. 1996 Jan;49(4):375-86. Unique Identifier : AIDSLINE MED/96218283; Yamamoto H; Hattori M; Ohashi K; Sugimoto C; Onuma M; Department of epizootiology, Faculty of Veterinary Medicine,; Hokkaido University, Sapporo, Japan.; The function of CD4+ T cells in antibody production was examined by using T cell subset-depleted chickens. CD4- and CD8-depleted chickens, established by the combination of thymectomy and injection of T cell subset-specific monoclonal antibodies, were immunized with sheep red blood cells (SRBC). Titers of anti-SRBC an
Interferon induction by HIV-1-infected cells: a possible role of sulfatides or related glycolipids.: Virology. 1996 Jul 1;221(1):113-9. Unique Identifier : AIDSLINE MED/96266420; Ankel H; Capobianchi MR; Frezza F; Castilletti C; Dianzani F; Medical College of Wisconsin, Milwaukee 53226, USA.; We have investigated the mechanism of interferon (IFN) induction in peripheral blood mononuclear cells by HIV-1(IIIB)-infected H9 cells or by recombinant gp120. A monoclonal antibody specific for the galactosylsphingosinyl moiety in galactocerebrosides and sulfatides inhibited IFN induction in a dose-dependent manner.
Antigenic variation of SIV: mutations in V4 alter the neutralization profile.: Virology. 1996 Jul 1;221(1):14-21. Unique Identifier : AIDSLINE MED/96266411; Kinsey NE; Anderson MG; Unangst TJ; Joag SV; Narayan O; Zink MC; Clements JE; Department of Comparative Medicine, Johns Hopkins University; School of Medicine, Baltimore, Maryland 21205, USA.; Antigenic variation is a characteristic feature of lentiviral infection. The SIV/macaque model of AIDS provides an ideal system in which to investigate the molecular basis of antigenic variation. The purpose of this study was to genetically map the nucleotide changes in env that alter the neutralization phenotype of S
Assembly and release of SIV env proteins with full-length or truncated cytoplasmic domains.: Virology. 1996 Jul 1;221(1):22-33. Unique Identifier : AIDSLINE MED/96266412; Vzorov AN; Compans RW; Department of Microbiology and Immunology, Emory University; School of Medicine, Atlanta, Georgia 30322, USA.; We have used recombinant vaccinia viruses expressing full-length or truncated gag or env genes of SIVmac239 to investigate the requirements for assembly of SIV proteins. We observed that assembly of virus-like particles (VLPs) was found to be 3- to 5-fold higher with full-length Env than with the truncated forms, or t
Lymphocytes are the major reservoir for foamy viruses in peripheral blood.: Virology. 1996 Jul 1;221(1):240-4. Unique Identifier : AIDSLINE MED/96266434; von Laer D; Neumann-Haefelin D; Heeney JL; Schweizer M; Abteilung Virologie, Institute fur Medizinische Mikrobiologie; und Hygiene, Freiburg, Germany.; Simian and human foamy virus (FV) DNA can be readily detected in peripheral blood leukocytes. However, it is unknown which leukocyte populations harbor the virus in vivo. We, therefore, analyzed blood samples from nine African green monkeys, four chimpanzees, and two humans for the presence of foamy virus proviral DNA
Tropical pyomyositis.: World J Surg. 1996 Jun;20(5):613-7. Unique Identifier : AIDSLINE MED/96268108; Ansaloni L; Department of Surgery, Dr. Ambrosoli Memorial Hospital, Kalongo,; Kitgum District, Uganda.; Tropical pyomyositis (TP), a suppurative disease caused predominantly by Staphylococcus aureus, is responsible for 3% to 4% of surgical admissions in some hospitals in certain tropical countries. This study describes the clinical features of 35 patients with TP (20 males, 15 females; mean +/- SD age 28.3 +/- 14.1 year
AIDS-related non-Hodgkin's lymphomas: molecular genetics, viral infection and cytokine deregulation.: Acta Haematol. 1996;95(3-4):193-8. Unique Identifier : AIDSLINE MED/96234649; Gaidano G; Pastore C; Gloghini A; Volpe G; Ghia P; Saglio G; Carbone A; Dipartimento di Scienze Biomediche e Oncologia Umana, Ospedale; San Luigi, Universita di Torino, Italia.; AIDS-related non-Hodgkin s lymphomas (AIDS-NHLs) are almost invariably derived from B cells and are grouped into three distinct histologic categories, including small-non-cleaved-cell lymphoma (SNCCL), diffuse large-cell lymphoma (DLCL), and anaplastic large-cell lymphoma (ALCL). In addition, AIDS-NHLs presenting sole
Anti-HIV viral interference induced by retroviral vectors expressing a nonproducer HIV-1 variant.: Acta Haematol. 1996;95(3-4):199-203. Unique Identifier : AIDSLINE MED/96234650; Federico M; Bona R; D'Aloja P; Baiocchi M; Pugliese K; Nappi F; Chelucci C; Mavilio F; Verani P; Laboratory of Virology, Istituto Superiore di Sanita, Rome,; Italy.; A Hut-78 cell clone (F12) harboring a nonproducer human immunodeficiency virus (HIV-1) variant shows complete resistance to HIV-1 or HIV-2 superinfection. The F12-HIV provirus produces an altered HIV-1 protein pattern and cannot generate even immature viral particles. We demonstrated that HeLa CD4+ cells transfected w
Suppression of hematopoietic support function is associated with overexpression of interleukin-4 and transforming growth factor-beta 1 in LP-BM5 murine-leukemia-virus-infected stromal cell lines.: Acta Haematol. 1996;95(3-4):204-12. Unique Identifier : AIDSLINE MED/96234651; Gallicchio VS; Tse KF; Morrow J; Hughes NK; Department of Internal Medicine, Lucille P. Markey Cancer Center,; Chandler Medical Center, University of Kentucky, Lexington; 0536-0084 (USA).; Murine acquired immunodeficiency syndrome (MAIDS) induced by defective LP-BM5 murine leukemia virus (MuLV) is a disease with many similarities to human AIDS. Our previous studies demonstrated that the depressed hematopoiesis observed in LP-BM5-infected marrow cultures could be attributed to a defective hematopoietic s
Ritonavir for advanced HIV infection [news]: Am Fam Physician. 1996 Jul;54(1):372, 374. Unique Identifier : AIDSLINE MED/96285309
First HIV antigen screening test [news]: Am Fam Physician. 1996 Jul;54(1):376-7. Unique Identifier : AIDSLINE MED/96285310
Public health policies for HIV/AIDS prevention [letter; comment]: Am Fam Physician. 1996 Jul;54(1):66, 68. Unique Identifier : AIDSLINE MED/96285285; Handsfield HH
Meglumine antimoniate-induced pancreatitis [letter]: Am J Gastroenterol. 1996 Apr;91(4):820-1. Unique Identifier : AIDSLINE MED/96186681; Torrus D; Massa B; Boix V; Portilla J; Perez-Mateo M
Failure to detect HTLV-I proviral DNA in the liver of a patient with primary biliary cirrhosis and HTLV-I-associated myelopathy [letter]: Am J Gastroenterol. 1996 Apr;91(4):827-8. Unique Identifier : AIDSLINE MED/96186689; Ijichi T; Miyata K; Nakajima K; Hashimoto K; Kashio N; Osame M
Frequency and clinical profile of precore and surface hepatitis B mutants in Asian-Indian patients with chronic liver disease [see comments]: Am J Gastroenterol. 1996 Jul;91(7):1312-7. Unique Identifier : AIDSLINE MED/96280495; Guptan RC; Thakur V; Sarin SK; Banerjee K; Khandekar P; Department of Gastroenterology, GB Pant Hospital, New Delhi,; India.; BACKGROUND. Infection due to hepatitis B virus (HBV) could be due to wild or mutant (precore or surface) viruses. The prevalence and clinical profile of different viral forms in patients with chronic liver disease has not been established. METHODS. One hundred and twenty patients with histologically proven HBV-related
Massive rectal bleeding from colonic tuberculosis.: Am J Gastroenterol. 1996 Jul;91(7):1439-41. Unique Identifier : AIDSLINE MED/96280521; Monkemuller KE; Lewis JB Jr; Department of Medicine, University of Tennessee and Baptist; Memorial Hospital, Memphis, USA.; We describe a patient with massive rectal bleeding from colonic tuberculosis. This is an uncommon presentation of gastrointestinal tuberculosis with fewer than 20 cases reported in the medical literature. The incidence of tuberculosis has been increasing during the last decade. The resurgence of tuberculosis (secondar
Albendazole-induced pseudomembranous colitis.: Am J Gastroenterol. 1996 Jul;91(7):1453-4. Unique Identifier : AIDSLINE MED/96280525; Shah V; Marino C; Altice FL; Section of Digestive Diseases, Yale University Medical School,; New Haven, Connecticut, USA.; We report a patient with AIDS and intestinal microsporidiosis . While undergoing treatment with albendazole, he developed worsening diarrhea with abdominal pain and fever. The diagnosis of pseudomembranous colitis was made by flexible sigmoidoscopy and a positive stool
Antituberculous drugs and hepatotoxicity [letter; comment]: Am J Gastroenterol. 1996 Jul;91(7):1471-2. Unique Identifier : AIDSLINE MED/96280537; Nishioka S de A
Safety of dapsone as Pneumocystis carinii pneumonia prophylaxis in human immunodeficiency virus-infected patients with allergy to trimethoprim/sulfamethoxazole.: Am J Med. 1996 Jun;100(6):611-6. Unique Identifier : AIDSLINE MED/96291116; Beumont MG; Graziani A; Ubel PA; MacGregor RR; Department of Medicine, University of Pennsylvania Medical; Center, Philadelphia, USA.; OBJECTIVE: To assess the safety of dapsone prophylaxis of Pneumocystis carinii pneumonia (PCP) in patients with prior intolerance to trimethoprim/sulfamethoxazole (TMP/SMX). METHODS: We conducted a retrospective study in the categorical human immunodeficiency virus out-patient program of a university hospital. Patient
Physician attitudes toward human immunodeficiency virus testing in pregnancy.: Am J Obstet Gynecol. 1996 Jun;174(6):1750-5; discussion 1755-6. Unique Identifier : AIDSLINE MED/96305860; Segal AI; OBJECTIVE: Our purpose was to determine physician attitudes regarding voluntary versus mandatory status of human immunodeficiency virus testing in pregnant women. STUDY DESIGN: A questionnaire was sent to a sampling of the membership in District IX of The American College of Obstetricians and Gynecologists. Members we
Advances in the management of AIDS-related cytomegalovirus retinitis [see comments]: Ann Intern Med. 1996 Jul 15;125(2):126-36. Unique Identifier : AIDSLINE MED/96282449; Masur H; Whitcup SM; Cartwright C; Polis M; Nussenblatt R; Critical Care Medicine Department, National Institutes of Health,; Bethesda, MD 20892, USA.; Cytomegalovirus ( CMV ) retinitis, a common complication of the acquired immunodeficiency syndrome (AIDS), is increasing in frequency as patients infected with the human immunodeficiency virus (HIV) live longer. In recent years, the lifetime risk for CMV disease i
Treatment of cytomegalovirus retinitis in patients with AIDS [editorial; comment]: Ann Intern Med. 1996 Jul 15;125(2):144-5. Unique Identifier : AIDSLINE MED/96282452; Jabs DA
Adult group B streptococcal disease [letter; comment]: Ann Intern Med. 1996 Jul 15;125(2):152-3. Unique Identifier : AIDSLINE MED/96282455; Waite DC; Alper EJ; Mady BJ
Tuberculous abscess of the prostate in AIDS [letter]: Ann Intern Med. 1996 Jul 15;125(2):156. Unique Identifier : AIDSLINE MED/96282461; Wolf LE
Treatment of cytomegalovirus retinitis with intravitreous cidofovir in patients with AIDS. A preliminary report [see comments]: Ann Intern Med. 1996 Jul 15;125(2):98-103. Unique Identifier : AIDSLINE MED/96282444; Rahhal FM; Arevalo JF; Chavez de la Paz E; Munguia D; Azen SP; Freeman WR; University of California School of Medicine, San Diego, USA.; BACKGROUND. Cytomegalovirus retinitis remains a major cause of illness in patients with the acquired immunodeficiency syndrome (AIDS), and existing therapies for this condition are relatively ineffective and toxic. OBJECTIVE. To evaluate the efficacy of intravitreous cidofovir injections alone for initial and maintena
Clinical and epidemiologic features of primary HIV infection.: Ann Intern Med. 1996 Aug 15;125(4):257-64. Unique Identifier : AIDSLINE MED/96301137; Schacker T; Collier AC; Hughes J; Shea T; Corey L; University of Washington, Seattle, USA.; BACKGROUND: The acute clinical events surrounding the acquisition of human immunodeficiency virus (HIV) have not been well characterized. OBJECTIVE: To further define the clinical and epidemiologic presentation of primary HIV infection. DESIGN: Descriptive cohort study. SETTING: University research clinic. PATIENTS: 4
Safety and immunogenicity of a candidate HIV-1 vaccine in healthy adults: recombinant glycoprotein (rgp) 120. A randomized, double-blind trial. NIAID AIDS Vaccine Evaluation Group.: Ann Intern Med. 1996 Aug 15;125(4):270-9. Unique Identifier : AIDSLINE MED/96301139; Graham BS; Keefer MC; McElrath MJ; Gorse GJ; Schwartz DH; Weinhold K; Matthews TJ; Esterlitz JR; Sinangil F; Fast PE; Vanderbilt University School of Medicine, Nashville, TN; 37232-2605, USA.; OBJECTIVE: To evaluate the safety and immunogenicity of recombinant glycoprotein (rgp) 120, a candidate vaccine for the human immunodeficiency virus (HIV), formulated with a novel adjuvant, MF59, with or without a biological response modifier, MTP-PE. DESIGN: Multicenter, double-blind, randomized trial. SETTING: Unive
Heterosexual transmission of HIV in Haiti.: Ann Intern Med. 1996 Aug 15;125(4):324-30. Unique Identifier : AIDSLINE MED/96301147; Deschamps MM; Pape JW; Hafner A; Johnson WD Jr; Cornell University Medical College, New York, New York, USA.; BACKGROUND: Despite the importance of human immunodeficiency virus (HIV) transmission through heterosexual contact, the incidence of HIV infection in heterosexual cohorts has not been well studied, particularly in the developing world. OBJECTIVE: To 1) determine the incidence of HIV infection in discordant heterosexua
Widespread papules and nodules in a Ugandan man with acquired immunodeficiency syndrome. African blastomycosis.: Arch Dermatol. 1996 Jul;132(7):821-2, 824. Unique Identifier : AIDSLINE MED/96280609; Cohen LM; Golitz LE; Wilson ML; University of Colorado School of Medicine, Denver General; Hospital, USA.
Absence of human T-cell lymphotropic virus genomic determinants in canine mycosis fungoides [letter]: Arch Dermatol. 1996 Jul;132(7):841-2. Unique Identifier : AIDSLINE MED/96280619; Fivenson DP; Schaffer J; Saed G; Beck ER; Wood GS
Recurrent pneumococcal bacteremia. A warning of immunodeficiency.: Arch Intern Med. 1996 Jul 8;156(13):1429-34. Unique Identifier : AIDSLINE MED/96268176; Rodriguez-Creixems M; Munoz P; Miranda E; Pelaez T; Alonso R; Bouza E; Division of Clinical Microbiology and Infectious Diseases-HIV,; Gregorio Maranon, General Hospital, University of Madrid,; Spain.; BACKGROUND. Recurrent pneumococcal infections are known to occur occasionally in patients with profound immune defects. We performed a case-control analysis of recurrent pneumococcal bacteremias). PATIENTS AND METHODS. The 547 episodes of Streptococcus pneumoniae bacteremia detected from January 1, 1985, to December 3
Bloodstream infections with vancomycin-resistant enterococci.: Arch Intern Med. 1996 Jul 8;156(13):1458-62. Unique Identifier : AIDSLINE MED/96268180; Montecalvo MA; Shay DK; Patel P; Tacsa L; Maloney SA; Jarvis WR; Wormser GP; Department of Medicine, New York Medical College, Valhalla, USA.; OBJECTIVES. To describe the population in whom bloodstream infections with vancomycin-resistant enterococci occur and the clinical and microbiologic features of infection. METHODS. From June 1, 1991, to January 31, 1994, 73 patients with bloodstream infections with vancomycin-resistant enterococci were identified by r
Neutropenia and iatrogenic neutrophil dysfunction in human immunodeficiency virus infection and acquired immunodeficiency syndrome [letter]: Arch Intern Med. 1996 Jul 8;156(13):1475-6. Unique Identifier : AIDSLINE MED/96268167; Arnott MA; Hay J
[Apropos of a case of malignant cardiac lymphoma in HIV infection (letter; comment)]: Arch Mal Coeur Vaiss. 1996 Feb;89(2):269. Unique Identifier : AIDSLINE MED/96263513; Le Heuzey JY; Pousset F; Pialoux G
Identification of a novel splice acceptor in the HIV-1 genome: independent expression of the cytoplasmic tail of the envelope protein.: Arch Virol. 1996;141(5):839-55. Unique Identifier : AIDSLINE MED/96265017; Berkhout B; van Wamel JL; Department of Virology, University of Amsterdam, The Netherlands.; Multiple splicing sites exist in the RNA genome of the human immunodeficiency virus type 1 (HIV-1). In a screen for subgenomic forms of the HIV-1 genome that could be transferred to fresh cells by virus infection, we identified a novel spliced variant of HIV-1 RNA that uses a hitherto unknown splice acceptor site with
Anti-EBNA1/anti-EBNA2 ratio decreases significantly in patients with progression of HIV infection.: Arch Virol. 1996;141(5):857-64. Unique Identifier : AIDSLINE MED/96265018; Winkelspecht B; Grasser F; Pees HW; Mueller-Lantzsch N; Abteilung Innere Medizin IV, Universitatskliniken des; Saarlandes, Homburg/Saar, Federal Republic of Germany.; Reactivation of EBV infection is common in immunocompromised individuals. We determined specific antibodies to EBV-encoded nuclear antigens (EBNA)1 and 2 in 102 sera of HIV-infected individuals. Anti-EBNA1/anti-EBNA2 ratio (E1/E2) is less than 1 in chronic infection and exceeds 1 in healthy EBV-positive carriers. 52%
Atopic allergy and other hypersensitivities editorial overview: technological advances and new insights into pathogenesis prelude novel therapeutic strategies [editorial]: Curr Opin Immunol. 1995 Dec;7(6):745-50. Unique Identifier : AIDSLINE MED/96274011; Romagnani S
Peptide modulation of allergen-specific immune responses.: Curr Opin Immunol. 1995 Dec;7(6):757-61. Unique Identifier : AIDSLINE MED/96274013; Hoyne GF; Kristensen NM; Yssel H; Lamb JR; Imperial College of Science, Technology and Medicine, London, UK.; In vitro peptide stimulation of allergen-reactive T-helper type 1 and type 0 cells, in the absence of costimulatory signals, induces anergy that is accompanied by the modulation of cell surface phenotype and changes in cytokine production. In experimental animal models, the administration of allergen-derived peptides
Role and modulation of T-cell cytokines in allergy.: Curr Opin Immunol. 1995 Dec;7(6):762-70. Unique Identifier : AIDSLINE MED/96274014; Daser A; Meissner N; Herz U; Renz H; Virchow Klinikum of the Humboldt University, Berlin, Germany.; Allergic sensitization and the development of effector functions are controlled by IL-4-secreting and IL-5-secreting type 2 T cells. Recent studies have provided new insights into the events triggering the development of type 1 and type 2 T cells, the discrimination of type 1 and type 2 effector T cells from various T
Antagonizing the differentiation and functions of human T helper type 2 cells.: Curr Opin Immunol. 1995 Dec;7(6):771-8. Unique Identifier : AIDSLINE MED/96274015; de Vries JE; Carballido JM; Sornasse T; Yssel H; Human Immunology Department, Research Institute of Molecular and; Cellular Biology, Palo Alto, CA 94304-1104, USA.; Allergen-specific T cells from atopic patients generally belong to the T-helper type 2 subset. IL-4 and IL-13 produced by these cells induce IgE synthesis by B cells and play a major role in allergic disease mediated by IgE. Recent advances in our understanding of the differentiation and IgE-inducing activities of T-h
The Th1/Th2 balance in autoimmunity.: Curr Opin Immunol. 1995 Dec;7(6):793-8. Unique Identifier : AIDSLINE MED/96274019; Charlton B; Lafferty KJ; John Curtin School of Medical Research, Australian National; University, Canberra.; The study of autoimmune disease in the context of T-helper type 1 (Th1) and T-helper type 2 (Th2) CD4+ T-cell responses demonstrates that the relative contribution of either T-cell type to the development of a particular autoimmune response can influence whether or not this response leads to clinical disease. Moreover
[AIDS-related knowledge and sex behavior: a review of Italian studies of young people]: Ann Ig. 1995 Sep-Oct;7(5):349-58. Unique Identifier : AIDSLINE MED/96288028; Aloisi MS; Girardi E; Ippolito G; Centro di Riferimento AIDS c/o Ospedale L. Spallanzani, Roma.; To plan further AIDS health promotion programmes information is needed about knowledge and attitudes relating to HIV infection among the general public. This article reviews the results of Italian studies conducted from 1990 to 1994 on young s knowledge and behaviour related to HIV infection. Eighteen studies were ide
Three methods for identification of true positive cloned cDNA fragment in differential display.: Biotechniques. 1996 Mar;20(3):400-4. Unique Identifier : AIDSLINE MED/96262563; Zhao S; Ooi SL; Yang FC; Pardee AB; Division of Cell Growth and Regulation, Dana-Farber Cancer; Institute, Boston MA 02115, USA. zhaoshan@mbcrr.harvard.edu
New insights into the role of host cell proteins in antiviral vaccine protection [letter]: AIDS Res Hum Retroviruses. 1995 Dec;11(12):1429-31. Unique Identifier : AIDSLINE MED/96288440; Montefiori DC
HLA class II on HIV particles is functional in superantigen presentation to human T cells: implications for HIV pathogenesis.: AIDS Res Hum Retroviruses. 1995 Dec;11(12):1433-9. Unique Identifier : AIDSLINE MED/96288441; Rossio JL; Bess J Jr; Henderson LE; Cresswell P; Arthur LO; National Cancer Institute-Frederick Cancer Research and; Development Center, Frederick, Maryland 21702, USA.; The mechanisms of immune suppression by the human immunodeficiency virus, HIV-1, are more complex than simple helper T cell deletion via infection and viral-induced lysis. Since the recent description of cellular proteins associated with HIV suggests that these proteins may be active in viral pathogenesis, the nature
Aspects of molecular interaction between HIV p17 and human gamma interferon.: AIDS Res Hum Retroviruses. 1995 Dec;11(12):1441-7. Unique Identifier : AIDSLINE MED/96288442; Flamminio G; Caruso A; Poiesi C; Bonfanti C; Terlenghi L; Donato Canaris A; Varinacci C; Martinelli F; Garotta G; Albertini A; et al; Institute of Microbiology, University of Brescia, Italy.; We describe the specific interaction between high-purity recombinant human immunodeficiency virus (HIV) type 1 p17 and human gamma interferon (hIFN-gamma) proteins. This interaction was found to be dose dependent and to involve conformational epitopes on both sides. Specificity was confirmed by competition ELISA, usin
A resting cell assay for improved detection of antibody-mediated neutralization of HIV type 1 primary isolates.: AIDS Res Hum Retroviruses. 1995 Dec;11(12):1449-58. Unique Identifier : AIDSLINE MED/96288443; Zolla-Pazner S; Sharpe S; Veterans Affairs Medical Center, New York, New York 10010, USA.; The sensitivity with which antibody-mediated neutralization is detected in vitro is dependent on the virus, the antibody, the target cells, and the culture conditions used in the assay. Using activated and transformed target cells, the ability of various culture-adapted and primary strains of HIV-1 to be neutralized b
Genetically engineered HIV type 1 peptides as tools for the determination of anti-V3 loop antibody titers in sera from HIV type 1-infected patients.: AIDS Res Hum Retroviruses. 1995 Dec;11(12):1459-65. Unique Identifier : AIDSLINE MED/96288444; Von Brunn A; Reichhuber C; Pfaff E; Wizemann H; Max-von-Pettenkofer-Institut, Ludwig-Maximilians-Universitat; Munchen, Munich, Germany.; Recombinant peptides from Escherichia coli encoding the principal neutralizing domain (PND) and surrounding sequences of gp120 of human immunodeficiency virus type 1 (HIV-1) with a C-terminal polyhistidine tag were expressed and purified on Ni(2+)-nitrilotriacetate agarose. High yields of more than 99% pure protein we
Redefinition of tropism of common macrophage-tropic human immunodeficiency virus type 1.: AIDS Res Hum Retroviruses. 1995 Dec;11(12):1467-71. Unique Identifier : AIDSLINE MED/96288445; Chowdhury IH; Potash MJ; Volsky DJ; Molecular Virology Laboratory, Columbia University, New York, New; York 10019, USA.; Previous studies have suggested that the abilities of human immunodeficiency virus type 1 (HIV-1) to infect primary macrophages and transformed T cell lines are mutually exclusive and define an important biological distinction among HIV-1 strains. In a survey of eight macrophage-tropic HIV-1 strains and nine T cell li
Temporal relationship between elongation of the HIV type 1 glycoprotein 120 V2 domain and the conversion toward a syncytium-inducing phenotype.: AIDS Res Hum Retroviruses. 1995 Dec;11(12):1473-8. Unique Identifier : AIDSLINE MED/96288446; Fouchier RA; Broersen SM; Brouwer M; Tersmette M; Van't Wout AB; Groenink M; Schuitemaker H; Department of Clinical Viro-Immunology, University of Amsterdam,; Netherlands.; The second and third variable domains (V2 and V3) of the human immunodeficiency virus type 1 (HIV-1) gp120 envelope molecule have been shown to be determinants of syncytium-inducing (SI) capacity. Previously we have reported evidence that increased length of the V2 domain and duplication or relocation of potential N-l
Safety and immunogenicity of a recombinant HIV type 1 glycoprotein 160 boosted by a V3 synthetic peptide in HIV-negative volunteers.: AIDS Res Hum Retroviruses. 1995 Dec;11(12):1479-86. Unique Identifier : AIDSLINE MED/96288447; Salmon-Ceron D; Excler JL; Sicard D; Blanche P; Finkielstzjen L; Gluckman JC; Autran B; Matthews TJ; Meignier B; Kieny MP; et al; Hopital Cochin, Paris, France.; The safety and the immunogenicity of a recombinant hybrid envelope glycoprotein MN/LAI (rgp160) followed by booster injections of a V3 (MN) linear peptide were evaluated in HIV-negative adults at low risk for HIV infection. Volunteers received either rgp160 in alum at 0, 1, and 6 months (group A), rgp160 at 0 and 1 mo
Replication of HIV type 1 in rabbit cell lines is not limited by deficiencies in tat, rev, or long terminal repeat function.: AIDS Res Hum Retroviruses. 1995 Dec;11(12):1487-93. Unique Identifier : AIDSLINE MED/96288448; Cho S; Kindt TJ; Zhao TM; Sawasdikosol S; Hague BF; Laboratory of Immunogenetics, National Institutes of Health,; Rockville, Maryland 20852, USA.; HIV-1 infection has been documented in rabbits, but infection proceeds slowly in this species. Human and rabbit cell lines were compared in order to identify barriers to efficient HIV-1 infection of rabbit cells. A direct comparison of human and rabbit CD4 as receptor for HIV-1 indicated that the rabbit CD4 homolog di
Bidirectional enhancing activities between human T cell leukemia-lymphoma virus type I and human cytomegalovirus in human term syncytiotrophoblast cells cultured in vitro.: AIDS Res Hum Retroviruses. 1995 Dec;11(12):1495-1507. Unique Identifier : AIDSLINE MED/96288449; Toth FD; Aboagye-Mathiesen G; Szabo J; Liu X; Mosborg-Petersen P; Kiss J; Hager H; Zdravkovic M; Andirko I; Aranyosi J; et al; Department of Virus and Cancer, Danish Cancer Society, Aarhus,; Denmark.; The syncytiotrophoblast layer of the human placenta has an important role in limiting transplacental viral spread from mother to fetus. Human cytomegalovirus (HCMV) is capable of establishing a latent infection in syncytiotrophoblast cells, with restriction of gene expression to im
Similar patterns of simian immunodeficiency virus env sequences are found in the blood and lymphoid tissues of chronically infected macaques.: AIDS Res Hum Retroviruses. 1995 Dec;11(12):1509-11. Unique Identifier : AIDSLINE MED/96288450; Slade A; Jones S; Jenkins A; Bootman J; Heath A; Kitchin P; Almond N; AIDS Collaborating Centre, National Institute of Biological; Standards and Control, Herts, UK.; Two cynomolgus macaques were infected with a genetically complex challenge stock of simian immunodeficiency virus (SIVmac251-32H). One animal developed SIV-induced disease and was sacrificed at 16 months postinfection. The second remained healthy until it too was sacrificed at 20 months postinfection. The polymerase c
Effects of total lymphoid irradiation on SIV-infected macaques.: AIDS Res Hum Retroviruses. 1995 Dec;11(12):1517-27. Unique Identifier : AIDSLINE MED/96288451; Fultz PN; Schwiebert RS; Su L; Salter MM; Department of Microbiology, University of Alabama School of; Medicine, Birmingham 35294, USA.; The identification of antiretroviral drugs that prevent, or delay for extended periods, progression of HIV-related disease has been of limited success. Because the number of HIV-infected people continues to increase, other therapeutic approaches must be tested. Using simian immunodeficiency virus (SIV)-infected macaqu
HTLV type I isolated from a Pygmy in Cameroon is related to but distinct from the known central African type.: AIDS Res Hum Retroviruses. 1995 Dec;11(12):1529-31. Unique Identifier : AIDSLINE MED/96288452; Chen J; Zekeng L; Yamashita M; Takehisa J; Miura T; Ido E; Mboudjeka I; Tsague JM; Hayami M; Kaptue L; Institute for Virus Research, Kyoto University, Sakyo-ku, Japan.
The phylogenetic relationship of HTLV type I from non-Mashhadi Iranians to that from Mashhadi Jews.: AIDS Res Hum Retroviruses. 1995 Dec;11(12):1533-35. Unique Identifier : AIDSLINE MED/96288453; Yamashita M; Kitze B; Miura T; Weber T; Fujiyoshi T; Takehisa J; Chen JL; Sonoda S; Hayami M; Institute for Virus Research, Kyoto University, Sakyo-ku, Japan.
Completion of nucleotide sequences of non-syncytium-inducing and syncytium-inducing HIV type 1 variants isolated from the same patient.: AIDS Res Hum Retroviruses. 1995 Dec;11(12):1537-41. Unique Identifier : AIDSLINE MED/96288454; Guillon C; Bedin F; Fouchier RA; Schuitemaker H; Gruters RA; UMR103 CNRS/bioMerieux, ENS Lyon, France.
Sequence analysis of the V1/V2 and V3 domains in an HIV-seronegative AIDS patient.: AIDS Res Hum Retroviruses. 1995 Dec;11(12):1539-41. Unique Identifier : AIDSLINE MED/96288455; Vallejo A; Bravo R; Heredia A; Soriano V; Dronda F; Hewlett IK; Laboratory of Molecular Virology, CBER, FDA, Rockville, Maryland; 20852-1448, USA.
HIV type 1 V3 sequences and the development of dementia during AIDS.: AIDS Res Hum Retroviruses. 1996 Apr 10;12(6):471-6. Unique Identifier : AIDSLINE MED/96296958; Di Stefano M; Wilt S; Gray F; Dubois-Dalcq M; Chiodi F; Microbiology and Tumor Biology Center, Karolinska Institute,; Stockholm, Sweden.; The most frequent neurological complication of AIDS is a dementia-like syndrome. Power and collaborators (J Virol 1994; 68:4643-4649) have reported an association between the clinical signs of AIDS dementia and the amino acid composition of two positions (305 and 329) within the V3 region of HIV-1 strains amplified fr
Sequence analysis of the V3 loop in brain and spleen of patients with HIV encephalitis.: AIDS Res Hum Retroviruses. 1996 Apr 10;12(6):477-82. Unique Identifier : AIDSLINE MED/96296959; Reddy RT; Achim CL; Sirko DA; Tehranchi S; Kraus FG; Wong-Staal F; Wiley CA; Neuropathology Division, Presbyterian University Hospital,; Pittsburgh, Pennsylvania 15213-2582, USA.; Infection with a particularly neurovirulent strain of HIV has been hypothesized to explain why only a subset of patients develops HIV encephalitis. We studied the third hypervariable region (V3) of multiple clones from both brains and spleens of three patients who died with HIV encephalitis, to see if there was a mole
Interaction of human immunodeficiency virus type 1 envelope glycoprotein gp120 with a galactoglycerolipid associated with human sperm.: AIDS Res Hum Retroviruses. 1996 Apr 10;12(6):483-9. Unique Identifier : AIDSLINE MED/96296960; Brogi A; Presentini R; Solazzo D; Piomboni P; Costantino-Ceccarini E; Istituto Biologia Generale, Universita Siena, Italy.; The expression of a molecule recognized by anti-galactosyl ceramide antibodies (MAb) O1 on the surface membrane of human spermatozoa was investigated by biochemical and immunochemical methods. Indirect immunofluorescence shows that this molecule is preferentially localized on the middle piece of the sperm tail. Immuno
Epitope specificity of anti-HIV antibodies in human and murine autoimmune diseases.: AIDS Res Hum Retroviruses. 1996 Apr 10;12(6):491-6. Unique Identifier : AIDSLINE MED/96296961; Fraziano M; Montesano C; Lombardi VR; Sammarco I; De Pisa F; Mattei M; Valesini G; Pittoni V; Colizzi V; Department of Biology, University of Rome Tor Vergata, Italy.; This article reports the HIV epitope specificity of antibodies present in the sera of HIV-negative patients with autoimmune diseases. Recombinant gp120 and a panel of synthetic peptides derived from the amino acid consensus sequences of either related (gp120, gp41, and p24) or unrelated (Mage-1, necdin, heat shock pro
Delayed virus-specific CD8+ cytotoxic T lymphocyte activity in an HIV-infected individual with high CD4+ cell counts: correlations with various parameters of disease progression.: AIDS Res Hum Retroviruses. 1996 Apr 10;12(6):497-506. Unique Identifier : AIDSLINE MED/96296962; Dalod M; Fiorentino S; Delamare C; Rouzioux C; Sicard D; Guillet JG; Gomard E; Unite d'Immunologie des Pathologies Infectieuses et Tumorales,; INSERM U445, Institut Cochin de Genetique Moleculaire, Paris,; France.; This 4-year longitudinal study monitored the temporal association between the HIV-specific cytotoxic T lymphocyte (CTL) response and the control viremia in an individual infected with human immunodeficiency virus type (HIV-1). At the beginning of the study, this asymptomatic individual with a high CD4+ cell count show
Drug combinations and effect parameters of zidovudine, stavudine, and nevirapine in standardized drug-sensitive and resistant HIV type 1 strains.: AIDS Res Hum Retroviruses. 1996 Apr 10;12(6):507-17. Unique Identifier : AIDSLINE MED/96296963; Zhu QY; Scarborough A; Polsky B; Chou TC; Molecular Pharmacology and Therapeutics Program, Memorial; Sloan-Kettering Cancer Center, New York, New York 10021, USA.; Reference strains of HIV-1 from the NIH AIDS Research and Reference Reagent Program, including wild-type IIIB, G762-3, and AZT resistant with RT 215T-->Y (G910-11/AZT); 67D-->N, 70K-->R, 215T-->F, 219K-->Q (G691-2/AZT); as well as
B cell epitopes of HIV type 1 p24 capsid protein: a reassessment.: AIDS Res Hum Retroviruses. 1996 Apr 10;12(6):519-25. Unique Identifier : AIDSLINE MED/96296964; Janvier B; Lasarte JJ; Sarobe P; Hoebeke J; Baillou-Beaufils A; Borras-Cuesta F; Barin F; Departement de Microbiologie Medicale et Moleculaire, URA; CNRS, CHRU Bretonneau, Tours, France.; The objective of the present study was to identify p24 antigenic domains recognized during natural human immunodeficiency virus type 1 (HIV-1) infection, the determination of the major epitopes of p24 having significant applications for both the improvement of diagnostic approaches and the development of vaccines. Rea
Cyclic AMP-mediated growth arrest is associated with increased expression of human T cell leukemia virus type I structural and transforming genes.: AIDS Res Hum Retroviruses. 1996 Apr 10;12(6):527-33. Unique Identifier : AIDSLINE MED/96296965; Poteat HT; Ramstedt U; Yoon S; Dardik M; Terwilliger E; Sodroski JG; Division of Human Retrovirology, Dana-Farber Cancer Institute,; Boston, Massachusetts 02115, USA.; The effect of increased intracellular cyclic AMP levels on gene expression of the human T cell leukemia virus type I (HTLV-I) provirus was examined. Induction of infected cells to produce elevated levels of cyclic AMP was associated with specific increases in viral surface antigen expression, protein synthesis, p24 re
Negative regulation of gene expression from the HTLV type II long terminal repeat by Rex: functional and structural dissociation from positive posttranscriptional regulation.: AIDS Res Hum Retroviruses. 1996 Apr 10;12(6):535-46. Unique Identifier : AIDSLINE MED/96296966; Watanabe CT; Rosenblatt JD; Bakker A; Morgan JP; Luo J; Chun S; Black AC; Department of Medicine, UCLA School of Medicine, Los Angeles,; California, USA.; Regulation of human T cell leukemia virus type II (HTLV-II) gene expression by Rex is mediated by cis-acting elements in the 5 viral long terminal repeat (LTR). Rex acts posttranscriptionally to enhance cytoplasmic accumulation of incompletely spliced viral mRNAs encoding structural proteins. We report a distinct neg
Temporal lobe electroencephalogram power modifications during olfactory stimulation in HIV-infected patients.: AIDS Res Hum Retroviruses. 1996 Apr 10;12(6):547-51. Unique Identifier : AIDSLINE MED/96296967; Grassi B; Locatelli M; Lazzarin A; Scarone S; Department of Biomedical and Technological Sciences, University; of Milan Medical School, Italy.; Evidence derived from studies concerning brain metabolism and brain electrical activity suggests that temporal lobe functioning is impaired in the course of HIV infection. To test the hypothesis of temporal lobe dysfunction in HIV infection, we utilized computerized electroencephalogram (EEG) analysis to evaluate temp
Complete DNA sequence of the gene encoding the external glycoprotein (gp120) from a Cuban HIV type 1 isolate.: AIDS Res Hum Retroviruses. 1996 Apr 10;12(6):553-5. Unique Identifier : AIDSLINE MED/96296968; Gomez CE; Fernandez JR; Iglesias E; Lopez AE; Lobaina L; Noa E; Diaz H; Herrera A; Rolo F; Duarte CA; Vaccine Division, Center for Genetic Engineering and; Biotechnology, Cubanacan, Havana, Cuba.
Sequences and phylogenetic analysis of the nef gene from Thai subjects harboring subtype E HIV-1.: AIDS Res Hum Retroviruses. 1996 Apr 10;12(6):557-60. Unique Identifier : AIDSLINE MED/96296969; Artenstein AW; Hegerich PA; Beyrer C; Rungruengthanakit K; Michael NL; Natpratan C; Division of Retrovirology, Walter Reed Army Institute of; Research, Rockville, Maryland 20850, USA.
Diversity of HIV type 1 envelope V3 loop region in saliva.: AIDS Res Hum Retroviruses. 1996 Apr 10;12(6):561-3. Unique Identifier : AIDSLINE MED/96296970; Kakizawa J; Ushijima H; Morishita Y; Oka S; Ikeda Y; Muller WE; Department of Maternal and Child Health, University of Tokyo,; Japan.
Human rights can mean better health [news]: Nurs Stand. 1995 Nov 29-Dec 5;10(10):14. Unique Identifier : AIDSLINE MED/96321977; Firn S
World AIDS Day. Crisis of silence.: Nurs Stand. 1995 Nov 29-Dec 5;10(10):20-1. Unique Identifier : AIDSLINE MED/96321981; George M
Practice tips: talking sex.: Nurs Stand. 1995 Nov 29-Dec 5;10(10):56. Unique Identifier : AIDSLINE MED/96321994; Beacham S
Simultaneous detection of multiple nucleic acid targets in a homogeneous format.: Biochemistry. 1996 Jun 25;35(25):8429-38. Unique Identifier : AIDSLINE MED/96292373; Nelson NC; Cheikh AB; Matsuda E; Becker MM; Gen-Probe Incorporated, San Diego, California 92121, USA.; The acridinium ester 4-(2-succinimidyloxycarbonylethyl)phenyl-10-methylacridinium 9-carboxylate trifluoromethane sulfonate (AE), which reacts rapidly with alkaline hydrogen peroxide to produce light, has been used as a detection label in a number of assay procedures, including nucleic acid probe-based systems [Nelson d
Alterations to the primer grip of p66 HIV-1 reverse transcriptase and their consequences for template-primer utilization.: Biochemistry. 1996 Jul 2;35(26):8553-62. Unique Identifier : AIDSLINE MED/96266153; Ghosh M; Jacques PS; Rodgers DW; Ottman M; Darlix JL; Le Grice SF; Center for AIDS Research and Division of Infectious Diseases,; Case Western Reserve University School of Medicine, Cleveland,; Ohio 44106, USA.; Alanine scanning mutagenesis was undertaken to evaluate the structural significance of Met230-His235 of the 66 kDa subunit of p66/p51 human immunodeficiency virus reverse transcriptase (HIV-1 RT). Together with Glu224-Trp229, these residues provide the framework of the p66 primer grip, whose proposed role is maintainid
A model of PSI dimerization: destabilization of the C278-G303 stem-loop by the nucleocapsid protein (NCp10) of MoMuLV.: Biochemistry. 1996 Jul 2;35(26):8705-14. Unique Identifier : AIDSLINE MED/96266170; Girard PM; de Rocquigny H; Roques BP; Paoletti J; Unite de Biochimie, URA 147 CNRS, Institut Gustave Roussy,; Villejuif, France.; We have shown that at low ionic strength (i.e., 100 mM NaCl) a short autocomplementary sequence spanning nucleotides C283 to G298 of MoMuLV RNA genome is involved in the process of PSI dimerization in vitro [Girard, P.-M., Bonnet-Mathoniere, B., Muriaux, D., & Paoletti, J. (1995) Biochemistry 34, 9785-9794]. In ord
In vitro analysis of the HIV-1 second strand-transfer reaction.: Biochim Biophys Acta. 1996 Jun 7;1307(2):193-204. Unique Identifier : AIDSLINE MED/96283815; Pop MP; Department of Biochemical Kinetics, Max-Planck-Institute for; Biophysical Chemistry, Gottingen, Germany.; Two strand-transfer reactions are required during the retroviral reverse transcription. The second strand-transfer is believed to occur at the primer binding site (PBS). By using an in vitro model system derived from the human immunodeficiency virus type-1 (HIV-1), molecular events related to the second strand-transfe
Lethal outcome of pelvic inflammatory disease in five women who were seropositive for HIV.: Eur J Surg. 1996 Jan;162(1):67-9. Unique Identifier : AIDSLINE MED/96272572; Quazi MA; Department of Surgery, Masvingo Provincial Hospital, Zimbabwe.
[Stability of human immunodeficiency virus to azidothymidine. II. Kinetic characteristics of AZT-resistant mutant forms of reverse transcriptase]: Biokhimiia. 1996 Jan;61(1):142-51. Unique Identifier : AIDSLINE MED/96288053; Pokholok DK; Gudima SO; Memelova LV; Esipov DS; Rechinskii VO; Kochetkov SN; V.A. Engelgardt Institute of Molecular Biology, Russian Academy; of Sciences, Moscow.; Prolonged treatment of AIDS patients with azidothymidine results in the development of resistance to the drug which correlates with the appearance of point mutations in the reverse transcriptase (RT) coding region within the HIV-1 pol gene. Kinetic studies of interactions of wild type RT and its mutants harbouring the
[HIV infection in women (editorial)]: An Med Interna. 1995 Dec;12(12):573-574. Unique Identifier : AIDSLINE MED/96286580; Cordero M
[Human immunodeficiency virus infection in women]: An Med Interna. 1995 Dec;12(12):576-83. Unique Identifier : AIDSLINE MED/96286581; Martin Suarez I; Aguayo Canela DM; Leon de Lope M; Cuesta Lopez F; Merino Munoz D; Galvez Aceval J; Creagh Cerquera R; Pujol de la Llave E; Servicio de Medicina Interna, Hospital Juan Ramon Jimenez,; Ronda Norte, Huelva.; From last years eighty s decade the number of women with HIV infection have significantly increased. To know the epidemiological and clinic trades in this group we studied retrospectively 476 HIV infected patients attending in a General Hospital from January 1986 to June 1993. Seventy nine (16.5%) were female and 397
[Varicella pneumonia in adults (letter)]: An Med Interna. 1995 Dec;12(12):618-9. Unique Identifier : AIDSLINE MED/96286592; Marti J; Anton E; Lerma A
[Present and future of the antiretroviral therapy (editorial)]: An Med Interna. 1996 Jan;13(1):1-3. Unique Identifier : AIDSLINE MED/96286217; Martinez-Vazquez JM; Cabarcos A
[Cerebral toxoplasmosis in patients with human immunodeficiency virus (HIV) infection. Clinico-radiological and therapeutic aspects in 63 patients]: An Med Interna. 1996 Jan;13(1):4-8. Unique Identifier : AIDSLINE MED/96286218; Ferrer S; Fuentes I; Domingo P; Munoz C; Iranzo A; Barrio JL; Fuster M; Ris J; Sambeat MA; Cadafalch J; Nolla J; Servicio de Medicina Interna, Universidad Autonoma, Barcelona.; We have retrospectively reviewed 63 cases of encephalic toxoplasmosis (ET) in HIV-infected patients in order to determine clinical and radiological characteristics, the diagnostic value of serologic determinations, and the response to antioxoplasmic therapy. ET was the AIDS-defining condition in 44% of the patients. E
[Usefulness of lithium in neutropenia associated with AIDS (letter)]: An Med Interna. 1996 Jan;13(1):49. Unique Identifier : AIDSLINE MED/96286234; Martinez Ruiz M; Llobell Segui G; Peralba Vano JI; Toral Revuelta JR
[Epidemiological study of tuberculosis in the health area of Santiago de Compostella in 1992, 1993 and 1994]: An Med Interna. 1996 Mar;13(3):111-4. Unique Identifier : AIDSLINE MED/96242367; Salgueiro M; Zamarron C; Otero Y; Alvarez-Dobano JM; Arias MR; Alvarez-Calderon P; Palacios A; Fernandez-Naveiro J; Perez del Molino ML; Rodriguez-Suarez JR; Servicio de Neumologia, Hospital General de Galicia; Clinico-Universitario, Santiago de Compostela.; An exhaustive search for the clinical records of patients diagnosed with tuberculous disease was done in the hospitals of the area under study, which involves 392,000 population. During the years 1992, 1993 and 1994. There were included: 1) patients who had positive bacilloscopy and/or positive Lowenstein s culture in
[Study of comparative immunity of patients with M. tuberculosis and atypical Mycobacteria infection and infection by human immunodeficiency virus (HIV)]: An Med Interna. 1996 Mar;13(3):115-7. Unique Identifier : AIDSLINE MED/96242368; Navarro V; Guix J; Roig P; Borras R; Servicio de Medicina Interna, Hospital General Alicant.; The purpose of this retrospective study was to determine the basal immune status, in patients with human immunodeficiency virus (HIV) infection, who were affected from tuberculosis (TB) caused by Mycobacterium tuberculosis or atypical mycobacterium. In the current study, we report our experience with 280 patients diag
[Light, more light. Some other concurrent hypotheses about etiopathogenesis of tuberculosis in our environment]: An Med Interna. 1996 Mar;13(3):146-8. Unique Identifier : AIDSLINE MED/96242376; Salgueiro Rodriguez M; Servicio de Neumologia, Hospital General de Galicia, Facultad de; Medicina, Santiago de Compostela.
[Impact of AIDS on premature mortality in La Rioja]: Aten Primaria. 1996 May 15;17(8):517-20. Unique Identifier : AIDSLINE MED/96244305; Ramalle-Gomara E; Gonzalez Martinez MA; Lezaun Larumbe ME; Consejeria de Salud, Consumo y Bienestar Social de La Rioja,; Logrono.; OBJECTIVE. To describe the evolution of the number of potential years of life lost (PYLL) because of AIDS in La Rioja between 1986 and 1993. DESIGN. Descriptive study. SETTING. Autonomous Community of La Rioja. PATIENTS AND OTHER PARTICIPANTS. Secondary data from the regional Register of AIDS cases in La Rioja, from t
Increased activation and altered ratio of interferon-gamma: interleukin-4 secreting cells in MRL-lpr/lpr mice.: Autoimmunity. 1995;21(2):107-16. Unique Identifier : AIDSLINE MED/96274295; Shirai A; Conover J; Klinman DM; Division of Viral Products, CBER/FDA, Bethesda, MD 20892, USA.; Cytokine specific ELIspot assays were used to monitor the number of cells secreting IL-4 and IFN gamma in MRL-lpr/lpr mice of different ages. The cytokine repertoire expressed by MRL-lpr/lpr mice was skewed towards the over-production of IFN gamma (and away from IL-4) when compared to that of MRL-+/-/+/- and BALB/c mi
Extrapunitive and intropunitive anger of HIV caregivers: nursing implications.: J Assoc Nurses AIDS Care. 1996 Mar-Apr;7(2):17-27. Unique Identifier : AIDSLINE MED/96265817; Phillips KD; Thomas SP; University of South Carolina, USA.; The purpose of this qualitative study was to investigate the anger of individuals who have provided direct patient care to loved ones who are living with or who have died from AIDS. The sample consisted of eight individuals who are currently involved in an AIDS service organization in northeast Tennessee. Data were co
Quality of life and coping styles of HIV-positive women with children.: J Assoc Nurses AIDS Care. 1996 Mar-Apr;7(2):28-34. Unique Identifier : AIDSLINE MED/96265818; Rose MA; Clark-Alexander B; School of Nursing, Medical College of Pennsylvania/Hahnemann; University, Philadelphia, USA.; This descriptive study explored the quality of life and coping methods of HIV positive women (N = 52) with children. The sample consisted of women with HIV/AIDS who answered an adapted Padilla Quality of Life Index and the Jalowiec Coping Scale. Among the psychological, physical, and social quality of life subscales,
Ethnography of an HIV hotel.: J Assoc Nurses AIDS Care. 1996 Mar-Apr;7(2):35-42. Unique Identifier : AIDSLINE MED/96265819; Carr G; AIDS Outpatient Clinic, UCSF AIDS Program, San Francisco General; Hospital, USA.; The human immunodeficiency virus (HIV) epidemic has created new communities of need among people infected with the virus who are already marginalized by poverty, sexual activity and identity, and drug use. An ethnography of one residential hotel in San Francisco, based on the concept of culture, reveals some themes in
Perceived health, HIV illness, and mental distress in African-American clients of AIDS counseling centers.: J Assoc Nurses AIDS Care. 1996 Mar-Apr;7(2):43-51. Unique Identifier : AIDSLINE MED/96265820; Linn JG; Anema MG; Hodess S; Sharpe C; Cain VA; School of Nursing, Tennessee State University, Nashville, USA.; The development of effective coping strategies may require that adults with HIV disease have an accurate, and to the extent possible, positive perception of their own health status. This has been found to be lacking among HIV-infected people with limited education/information, including many minority adults. The objec
Liposomal doxorubicin (Doxil).: J Assoc Nurses AIDS Care. 1996 Mar-Apr;7(2):55-9. Unique Identifier : AIDSLINE MED/96265821; Porche DJ
Chimerism after organ transplantation: is there any clinical significance?: Clin Transplant. 1996 Feb;10(1 Pt 2):110-7. Unique Identifier : AIDSLINE MED/96252072; Burlingham WJ; Department of Surgery, University of Wisconsin Hospital and; Clinics, Madison 53792, USA.; Historically, attempts to clinically correlate microchimerism and cytotoxic T lymphocyte (CTL) dysfunction with allograft tolerance (via a veto effect) have not been highly successful. We have re-examined this question by studying the case of JB, a maternal-renal allograft recipient who did not develop symptoms of acu
Advising your clients on a healthy holiday.: Prof Care Mother Child. 1994 May;4(4):93-7. Unique Identifier : AIDSLINE MED/96317402; Gleeson C; Immunisations often need to be started two or three months before departure, so advise clients to consult the practice in good time. A pre-travel health interview can be an excellent focus for health education. Parents of young children going abroad may benefit from advice on infant feeding avoiding sunburn and being
Deafness in childhood: 1. Diagnosis and treatment of deaf babies and children.: Prof Care Mother Child. 1994 Aug-Sep;4(6):180-3. Unique Identifier : AIDSLINE MED/96317441; Bysshe J; Recent technological advances make it possible to detect hearing impairments in very young babies. Babies as young as a few weeks old can now be helped with hearing aids and early language therapy. The earlier the diagnosis and start of treatment, the better the later performance in speech. Nurses and midwives, togeth
AIDS and tuberculosis control programmes: an integrated approach at educational level.: Monaldi Arch Chest Dis. 1996 Apr;51(2):102-7. Unique Identifier : AIDSLINE MED/96267940; Migliori GB; Spanevello A; Manfrin V; Abongomera A; Pedretti RF; Ballardini L; Neri M; Borghesi A; Depts of Pneumology, Fondazione Salvatore Maugeri, Tradate; Medical Centre, Italy.; In developing countries with a high prevalence of individuals co-infected by human immunodeficiency virus (HIV) and tuberculosis (TB), urgent public health measures should be implemented to prevent the spread of both diseases. This study was performed by a combined acquired immune deficiency syndrome (AIDS)-TB health
Applications of heteroduplex analysis for mutation detection in disease genes.: Hum Mutat. 1995;6(4):281-7. Unique Identifier : AIDSLINE MED/96287377; Glavac D; Dean M; National Institute of Chemistry, Ljubljana, Slovenia.; Double-stranded heteroduplex molecules that form between a mutant and wild-type DNA strand are often distinguished from homoduplex molecules upon gel electrophoresis. This method, heteroduplex analysis (HA), can be performed rapidly without radioisotopes or specialized equipment. Modifications and enhancements of the
Update on immunization.: Curr Opin Pediatr. 1996 Feb;8(1):21-7. Unique Identifier : AIDSLINE MED/96251415; Forrest JM; Burgess MA; Australian Centre for Immunisation Research, Royal Alexandra; Hospital for Children, Parramatta NSW, Australia.; By 1995, measles, mumps, and rubella were eliminated from Finland , acellular vaccines for pertussis were showing great promise, and the global eradication of poliomyelitis by the year 2000 looked possible. The meningococcus was repl
Malignancies in pediatric AIDS.: Curr Opin Pediatr. 1996 Feb;8(1):45-9. Unique Identifier : AIDSLINE MED/96251419; Mueller BU; Pizzo PA; Pediatric Branch, National Cancer Institute, Bethesda, MD; 20892-1928, USA.; Patients with immunodeficiency disorders, including children infected with HIV type 1, are at increased risk to develop a malignancy. Although the exact incidence is not clear, an excess of non-Hodgkin s lymphomas, soft tissue tumors, and, in the case of adolescent girls, cervical carcinomas, has been reported in HIV-
Neonatal infections.: Curr Opin Pediatr. 1996 Feb;8(1):6-10. Unique Identifier : AIDSLINE MED/96251412; Greenough A; Department of Child Health, King's College Hospital, London, UK.; Neonatal infection still carries a high mortality and morbidity. The spectrum of infection is broad and includes congenital syphilis and viral infections. Sadly, nosocomial infection is common, particularly due to coagulase negative staphylococci. Very low birth weight infants are at high risk, particularly following
Acute varicella hepatitis in human T-cell lymphotrophic virus types I and II infection.: J Gastroenterol. 1996 Apr;31(2):273-7. Unique Identifier : AIDSLINE MED/96253684; Mathur S; Achari A; Green L; Anand BS; Department of Internal Medicine, V.A. Medical Center, Houston, TX; 77030, USA.; Varicella (chicken pox) is a common viral infection in children and generally runs a benign course. However, in adults, and especially in immunocompromised subjects such as those on immunosuppressant therapy or with AIDS, varicella infection is particularly severe and is associated with the formation of hemorrhagic sk
Problems in interpreting HIV sentinel seroprevalence studies.: Ann Epidemiol. 1995 Nov;5(6):447-54. Unique Identifier : AIDSLINE MED/96287366; Strickler H; Hoover DR; Dersimonian R; Viral Epidemiology Branch, Division of Cancer Etiology, National; Cancer Institute, National Institutes of Health, Rockville, MD; 20852, USA.; Estimating human immunodeficiency virus (HIV) prevalence from sentinel seroprevalence studies is difficult. We characterize these studies and show that most are investigations of incompletely defined (hypothetical) cohorts and are usually based on nonprobability samples. Prevalence in HIV sentinel serosurveys is also
Pulmonary complications of HIV infection in Dar es Salaam, Tanzania. Role of bronchoscopy and bronchoalveolar lavage.: Am J Respir Crit Care Med. 1996 Jul;154(1):105-10. Unique Identifier : AIDSLINE MED/96291142; Daley CL; Mugusi F; Chen LL; Schmidt DM; Small PM; Bearer E; Aris E; Mtoni IM; Cegielski JP; Lallinger G; Mbaga I; Murray JF; Division of Pulmonary and Critical Care Medicine, University of; California, San Francisco 94143-0841, USA.; To determine the pulmonary complications in HIV-1-infected patients in Dar es Salaam, Tanzania , and to evaluate the diagnostic utility of bronchoscopy and bronchoalveolar lavage, we carried out a prospective study of 237 patients with acute respiratory disease who were hospitaliz
The American Lung Association Conference on re-establishing control of tuberculosis in the United States.: Am J Respir Crit Care Med. 1996 Jul;154(1):251-62. Unique Identifier : AIDSLINE MED/96291166
[Comparative characterization of results of the immunoenzyme method of interleukin-1 determination in blast transformation reaction with indomethacin]: Klin Lab Diagn. 1996 Mar-Apr;(2):42-3. Unique Identifier : AIDSLINE MED/96256980; Plavan VV; Shemshura AB; Siziakina LP; Comparison of the results of blast transformation test and enzyme immunoassay of interleukin-1 in the blood serum and culture fluid demonstrated that assessment of phytohemagglutinin (PHA)-effected level of proliferative activity of lymphocytes is more informative for the diagnosis of manifest forms of HIV infection.
Direct quantification of HIV-1 RNA in human plasma by free solution capillary electrophoresis (FSCE).: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jun 1;12(2):107-11. Unique Identifier : AIDSLINE MED/96279839; Fernandez-Arcas N; Dieguez-Lucena JL; Garcia-Villanova JG; Pena J; Morell-Ocana M; Reyes-Engel A; Department of Biochemistry and Molecular Biology, Faculty of; Medicine, University of Malaga, Spain.; SUMMARY: The levels of human immunodeficiency virus type 1 (HIV-1) RNA have been directly quantitated, after an isolation step, in plasma from patients with primary HIV-1 infection by free solution capillary electrophoresis (FSCE) with ultraviolet detection. HIV-1 RNA was detected and quantified at physiological level
Overexpression of monosialoganglioside GM3 on lymphocyte plasma membrane in patients with HIV infection.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jun 1;12(2):112-9. Unique Identifier : AIDSLINE MED/96279840; Sorice M; Garofalo T; Sansolini T; Griggi T; Circella A; Massetti A; Tai T; Pavan A; Dipartimento di Medicina Sperimentale e Patologia, Universita di; Roma La Sapienza, Italy.; SUMMARY: This study was undertaken to analyze both the GM3 expression on peripheral blood lymphocytes of HIV-infected patients and the relationship between ganglioside content and anti-GM3 reactivity. GM3 expression was determined as a percentage of lipid-bound sialic acid and by cytofluorimetric analysis in 25 AIDS p
Canventol inhibits HIV-1 replication by Tat-induced Tar-independent mechanism.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jun 1;12(2):120-7. Unique Identifier : AIDSLINE MED/96279841; Biswas DK; Tius MA; Zhuo J; Pardee AB; Division of Cell Growth and Regulation, Dana-Farber Cancer; Institute and Harvard Medical School, Boston, Massachusetts,; U.S.A.; SUMMARY: Canventol (2-isopropyl-4-isopropyldencyclohex-2-ene-l-ol), a blocker of tumor necrosis factor alpha (TNF-alpha) release, inhibits human immunodeficiency virus type (HIV-1) production in chronically and acutely infected cells. This effect of Canventol on virus replication could be correlated with its inhibitor
Wild-type and transactivation-defective mutants of human immunodeficiency virus type 1 Tat protein bind human TATA-binding protein in vitro.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jun 1;12(2):128-38. Unique Identifier : AIDSLINE MED/96279842; Wang Z; Morris GF; Rice AP; Xiong W; Morris CB; Department of Pathology and Laboratory Medicine, Tulane Cancer; Center, Tulane University Medical Center, New Orleans, USA.; SUMMARY: Tat regulates human immunodeficiency virus type 1 (HIV-1) gene expression by increasing both the rate of transcription initiation and the efficiency of transcription elongation. The ability of Tat to facilitate HIV-1 transcription preinitiation complex formation suggests that components of the basal transcrip
JCV-DNA and BKV-DNA in the CNS tissue and CSF of AIDS patients and normal subjects. Study of 41 cases and review of the literature.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jun 1;12(2):139-46. Unique Identifier : AIDSLINE MED/96279843; Vago L; Cinque P; Sala E; Nebuloni M; Caldarelli R; Racca S; Ferrante P; Trabottoni G; Costanzi G; Institute of Medical Sciences, University of Milan, Italy.; SUMMARY: We studied the distribution and localization of the human papova-viruses JCV and BKV in the central nervous system (CNS) and cerebrospinal fluid (CSF) of HIV-positive patients with and without progressive multifocal leukoencephalopathy (PML) as compared with HIV-seronegative patients. The presence of JCV-DNA
Pilot study of topical trifluridine for the treatment of acyclovir-resistant mucocutaneous herpes simplex disease in patients with AIDS (ACTG 172). AIDS Clinical Trials Group.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jun 1;12(2):147-52. Unique Identifier : AIDSLINE MED/96279844; Kessler HA; Hurwitz S; Farthing C; Benson CA; Feinberg J; Kuritzkes DR; Bailey TC; Safrin S; Steigbigel RT; Cheeseman SH; McKinley GF; Wettlaufer B; Owens S; Nevin T; Korvick JA; Department of Medicine, Rush Medical College, Chicago, IL 60612,; U.S.A.; SUMMARY: Twenty-six AIDS patients were enrolled in an open label pilot study to evaluate the efficacy and toxicity of topical 1 percent ophthalmic trifluridine solution for the treatment of chronic mucocutaneous herpes simplex virus disease unresponsive to at least 10 days of acyclo
Double-blind placebo-controlled pilot trial of acemannan in advanced human immunodeficiency virus disease.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jun 1;12(2):153-7. Unique Identifier : AIDSLINE MED/96279845; Montaner JS; Gill J; Singer J; Raboud J; Arseneau R; McLean BD; Schechter MT; Ruedy J; Canadian HIV Trials Network, St. Paul's Hospital/University of; British Columbia, Vancouver, Canada.; SUMMARY: We assessed the safety and surrogate markers effect of acemannan as an adjunctive to antiretroviral therapy among patients with advanced HIV disease receiving zidovudine (ZDV) or didanosine (ddI) in a randomized, double-blind, placebo-controlled trial of acemannan (400 mg orally four times daily). Eligible p
Long-term administration of aerosolized pentamidine as primary prophylaxis against Pneumocystis carinii pneumonia in infants and children with symptomatic human immunodeficiency virus infection. The Italian Pediatric Collaborative Study Group on Pentamidine.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jun 1;12(2):158-63. Unique Identifier : AIDSLINE MED/96279846; Principi N; Marchisio P; Onorato J; Gabiano C; Galli L; Caselli D; Morandi B; Campelli A; Clerici M; Gattinara GC; Pediatric Department 4, University of Milan, Italy.; SUMMARY: We assessed the long-term feasibility, safety, and tolerability of two regimens of aerosolized pentamidine (AP) as primary prophylaxis of Pneumocystis carinii pneumonia (PCP) in a large sample of infants and children with symptomatic HIV infection in 21 pediatric departments. One hundred forty children were a
Inhibition of murine AIDS by combination of AZT and dideoxycytidine 5'-triphosphate.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jun 1;12(2):164-73. Unique Identifier : AIDSLINE MED/96279847; Fraternale A; Casabianca A; Rossi L; Chiarantini L; Brandi G; Aluigi G; Schiavano GF; Magnani M; Istituto di Chimica Biologica Giorgio Fornaini, University of; Urbino, Italy.; SUMMARY: A combination of antiretroviral drugs acting on different cell types (lymphocytes and macrophages) was evaluated in a murine retrovirus-induced immunodeficiency model of AIDS (MAIDS). In a first experiment, C57BL/6 mice were infected with a single i.p. administration of LP-BM5 and treated with 0.125 or 0.25 m
The use of auxiliary events to improve the analysis of survival for HIV-infected patients: application to the French Prospective Multicenter Cohort (SEROCO).: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jun 1;12(2):174-81. Unique Identifier : AIDSLINE MED/96279848; Flandre P; Boufassa F; Gerard L; Carre N; Persoz A; Meyer L; Inserm U 436, Paris, France.; SUMMARY: A multicenter prospective cohort study, including 512 patients for whom date of HIV infection was known, showed that the use of an appropriate auxiliary event can improve the analysis of survival data and lead to an earlier detection of risk factors for HIV patients. Age at seroconversion and primary symptoma
An intensive chemotherapy of adult T-cell leukemia/lymphoma: CHOP followed by etoposide, vindesine, ranimustine, and mitoxantrone with granulocyte colony-stimulating factor support.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jun 1;12(2):182-6. Unique Identifier : AIDSLINE MED/96279849; Taguchi H; Kinoshita KI; Takatsuki K; Tomonaga M; Araki K; Arima N; Ikeda S; Uozumi K; Kohno H; Kawano F; Kikuchi H; Takahashi H; Tamura K; Chiyoda S; Tsuda H; Nishimura H; Hosokawa T; Matsuzaki H; Momita S; Yamada O; Miyoshi I; Department of Medicine, Kochi Medical School, Japan.; SUMMARY: An intensive combination chemotherapy regimen supported by granulocyte colony-stimulating factor (G-CSF) was evaluated in adult T-cell leukemia/lymphoma (ATLL) patients in a multiinstitutional, cooperative study. Vincristine 1 mg/m2 i.v. day 1, Adriamycin 40 mg/m2 i.v. day 1, cyclophosphamide 400 mg/m2 i.v. d
Mother-to-child transmission of human T-cell lymphotropic virus types I and II (HTLV-I/II) in Gabon: a prospective follow-up of 4 years.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jun 1;12(2):187-92. Unique Identifier : AIDSLINE MED/96279850; Nyambi PN; Ville Y; Louwagie J; Bedjabaga I; Glowaczower E; Peeters M; Kerouedan D; Dazza M; Larouze B; van der Groen G; Delaporte E; Institute of Tropical Medicine, Antwerp, Belgium.; SUMMARY: For 4 years. we determined the mode and risk of mother-to-child transmission of HTLV-I in a prospective cohort of 34 children born to seropositive mothers in Franceville, Gabon . We also determined the prevalence of antibodies to HTLV-I/II in siblings born to seropositive mo
Male-to-female transmission of human T-cell lymphotropic virus types I and II: association with viral load. The Retrovirus Epidemiology Donor Study Group.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jun 1;12(2):193-201. Unique Identifier : AIDSLINE MED/96279851; Kaplan JE; Khabbaz RF; Murphy EL; Hermansen S; Roberts C; Lal R; Heneine W; Wright D; Matijas L; Thomson R; Rudolph D; Switzer WM; Kleinman S; Busch M; Schreiber GB; Retrovirus Diseases Branch, Division of Viral and Rickettsial; Diseases, National Center for Infections Diseases, Center for; Disease Control and Prevention, Atlanta, GA 30333, U.S.A.; SUMMARY: Risk factors for male-to-female sexual transmission of human T-lymphotropic virus types I and II (HTLV-I/II) were investigated among HTLV-seropositive volunteer blood donors and their long-term (> or = 6 month) sex partners. Direction of transmission in concordantly seropositive pairs was assessed by analyzin
The prevalence of additional injection-related HIV risk behaviors among injection drug users.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jun 1;12(2):202-7. Unique Identifier : AIDSLINE MED/96279852; Koester S; Booth RE; Zhang Y; Department of Psychiatry, University of Colorado Health Sciences; Center, Denver, U.S.A.; SUMMARY: This study assesses the prevalence of injection-related behaviors that may facilitate HIV transmission even when syringes are not directly shared. Subjects who self-reported practicing these indirect sharing behaviors are described, the prevalence of these behaviors are compared with the direct sharing of syr
Proviral HTLV-I and HTLV-II in the Efe pygmies of northeastern Zaire [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jun 1;12(2):208-9. Unique Identifier : AIDSLINE MED/96279853; Goubau P; Vandamme A; Beuselinck K; Desmyter J
Long survival in AIDS-related cytomegalovirus retinitis [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jun 1;12(2):209-10. Unique Identifier : AIDSLINE MED/96279854; Sandy CJ; Bloom PA; Waldron S; Migdal CS
Utility of SHIV for testing HIV-1 vaccine candidates in macaques.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jun 1;12(2):99-106. Unique Identifier : AIDSLINE MED/96279838; Lu Y; Salvato MS; Pauza CD; Li J; Sodroski J; Manson K; Wyand M; Letvin N; Jenkins S; Touzjian N; Chutkowski C; Kushner N; LeFaile M; Payne LG; Roberts B; Virus Research Institute, Cambridge, Massachusetts 02138, USA.; SUMMARY: Intravenous injection of SHIV (simian/human immunodeficiency virus, chimeric virus) into rhesus macaques resulted in a viremia in peripheral blood lymphocytes (PBL) and the generation of anti-HIV-1 (human immunodeficiency virus type 1) envelope immune responses. A challenge stock of a SHIV containing HIV-1 HX
Drug resistance in cytomegalovirus: current knowledge and implications for patient management.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996;12 Suppl 1:S1-22. Unique Identifier : AIDSLINE MED/96319512
Mutations at the capsid-nucleocapsid cleavage site of gag polyprotein of Moloney murine leukemia virus abolish virus infectivity.: C R Acad Sci III. 1996 Feb;319(2):81-9. Unique Identifier : AIDSLINE MED/96307522; Housset V; Darlix JL; Rhone-Poulenc Rorer, centre de recherche de Vitry-Alfortville,; Vitry-sur-Seine.; Capsid protein CAp30 and nucleocapsid protein NCp10 of Moloney murine leukemia virus (MoMuLV) are the 2 major proteic components of the virion core and are generated by processing of the gag polyprotein precursor, Pr65gag, by the viral protease. In the virion core, several hundred NCp10 molecules are bound to the geno
HIV-infected patients and dental care: nondisclosure of HIV status and rejection for treatment.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Dec;80(6):655-9. Unique Identifier : AIDSLINE MED/96287906; McCarthy GM; Haji FS; Mackie ID; Division of Oral Biology, University of Western Ontario, London,; Ontario, Canada.; OBJECTIVE: To investigate reports of nondisclosure of HIV-seropositivity to dentists by HIV-infected patients and their rejection for dental treatment. STUDY DESIGN: An anonymous self-administered questionnaire was completed by 101 consecutive consenting HIV-infected patients. RESULTS: Eighty percent of respondents (m
[The IgA immune system for mucosal vaccine: role of levels one and two Th2 cytokine producing T cells]: Nihon Rinsho Meneki Gakkai Kaishi. 1996 Feb;19(1):114-8. Unique Identifier : AIDSLINE MED/96231694; Shimaoka M; Hiroi T; Kiyono H; Department of Mucosal Immunology, Osaka University, Japan.
[Progresses in communicable diseases in China, 1995]: Chung Hua I Hsueh Tsa Chih. 1995 Dec;75(12):726-8. Unique Identifier : AIDSLINE MED/96286962; Si C
[Kaposi sarcoma of the glans penis with meatal obstruction. Case report and literature review]: Swiss Surg. 1996;(3):134-6. Unique Identifier : AIDSLINE MED/96244355; John H; Pestalozzi DM; Hauri D; Urologische Klinik, Universitatsspital Zurich.; Kaposi sarcoma was first described by Moritz Kaposi 1872. It is a disease of the reticuloendothelial system. Preferred manifestations are mainly skin, mucosa and gastrointestinal tract. Location of penile glans with meatal obstruction has been mentioned to date in 4 cases. We report a patient with acquired immune defi
Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain.: Cell. 1996 Jun 14;85(6):931-42. Unique Identifier : AIDSLINE MED/96279837; Lee CH; Saksela K; Mirza UA; Chait BT; Kuriyan J; The Rockefeller University, New York, New York 10021, USA.; The crystal structure of the conserved core of HIV-1 Nef has been determined in complex with the SH3 domain of a mutant Fyn tyrosine kinase (a single amino acid substitution, Arg-96 to isoleucine), to which Nef binds tightly. The conserved PxxP sequence motif of Nef, known to be important for optimal viral replication
Pharmacokinetics of F105, a human monoclonal antibody, in persons infected with human immunodeficiency virus type 1.: Clin Pharmacol Ther. 1996 Jun;59(6):662-7. Unique Identifier : AIDSLINE MED/96290506; Wolfe EJ; Cavacini LA; Samore MH; Posner MR; Kozial C; Spino C; Trapnell CB; Ketter N; Hammer S; Gambertoglio JG; Division of Clinical Pharmacy, University of California, San; Francisco 94143-0622, USA.; F105 is a human monoclonal antibody that binds to the CD4 binding site of human immunodeficiency virus type 1 gp120 and neutralizes clinical and laboratory isolates of the human immunodeficiency virus. This phase I study investigated the disposition of the antibody in humans. F105 was administered over a 60-minute per
[Magnetic resonance in AIDS-related encephalopathy]: Clin Ter. 1995 Dec;146(12):843-56. Unique Identifier : AIDSLINE MED/96307821; Gualdi GF; Di Biasi C; D'Agostino A; Trasimeni G; Melone A; Istituto di I Clinica Medica, Universita degli Studi di Roma.; Fifty-eight patients with AIDS disease were studied with MR imaging in the aim of detecting the grade of brain involvement. The examinations were performed with a 1.5 Tesla magnet. Thirty-seven showed white matter lesion (63.5%), twenty-five patients showed cerebral atrophy (43%), in eight patients the MR appearance w
Acquired immunodeficiency syndrome, Pneumocystis carinii pneumonia, and futility [editorial; comment]: Crit Care Med. 1996 Jun;24(6):907-9. Unique Identifier : AIDSLINE MED/96283662; Notterman DA
Prospective, controlled study of the outcome of human immunodeficiency virus-1 antibody-positive children admitted to an intensive care unit [see comments]: Crit Care Med. 1996 Jun;24(6):963-7. Unique Identifier : AIDSLINE MED/96283675; Jeena PM; Coovadia HM; Bhagwanjee S; Department of Pediatrics, Faculty of Medicine, University of; Natal, Durban, South Africa.; OBJECTIVE: Intensive care resources are both scarce and costly in South Africa . We set out to ascertain whether human immunodeficiency virus (HIV) status affects the spectrum of disease and the prognosis in children treated in pediatric intensive care units (ICUs). DESIGN: A prosp
The safety of i.v. pentamidine administered in an ambulatory setting.: Chest. 1996 Jul;110(1):136-40. Unique Identifier : AIDSLINE MED/96285243; Yeung KT; Chan M; Chan CK; Department of Medicine, Toronto Hospital and Wellesley Hospital,; University of Toronto, Ontario, Canada.; I.v. pentamidine is well known to cause severe multiorgan adverse effects and is usually given to hospitalized patients under close monitoring. The primary purpose of this retrospective quality assurance study is to assess the safety of administering i.v. pentamidine in the medical daycare unit (MDCU) for outpatients.
An effectiveness community-based clinical trial of Respirgard II and Fisoneb nebulizers for Pneumocystis carinii prophylaxis with aerosol pentamidine in HIV-infected individuals. Toronto Aerosol Pentamidine Study (TAPS) Group.: Chest. 1996 Jul;110(1):141-6. Unique Identifier : AIDSLINE MED/96285244; McIvor RA; Berger P; Pack LL; Rachlis A; Chan CK; Department of Medicine, Sunnybrook Health Science Centre,; University of Toronto, Canada.; STUDY OBJECTIVE: To compare the effectiveness of a standard jet nebulizer, Respirgard II, and a standard ultrasonic nebulizer, Fisoneb, for the administration of aerosolized pentamidine (AP) as primary and secondary prophylaxis against Pneumocystis carinii pneumonia (PCP) in HIV-infected individuals. DESIGN: A retrosp
A death associated with therapy for nosocomially acquired multidrug-resistant tuberculosis [see comments]: Chest. 1996 Jul;110(1):279-81. Unique Identifier : AIDSLINE MED/96285265; Weltman AC; DiFerdinando GT Jr; Washko R; Lipsky WM; Bureau of Tuberculosis Control, New York State Department of; Health, Albany, USA.; Treatment of multidrug-resistant tuberculosis is difficult and has been associated rarely with severe side effects. We report the nosocomial transmission of multidrug-resistant tuberculosis to a health-care worker who was seronegative for HIV infection. She died because of liver failure associated with treatment for a
[Proteinase blockade as active principle against HIV (news)]: Dtsch Med Wochenschr. 1996 Mar 8;121(10):A25. Unique Identifier : AIDSLINE MED/96296731; Weismann H
[Euphoria in HIV therapy (news)]: Dtsch Med Wochenschr. 1996 Mar 8;121(10):A28. Unique Identifier : AIDSLINE MED/96296732; Weismann H
[AIDS therapy on the upwind (news)]: Dtsch Med Wochenschr. 1996 Mar 15;121(11):A7-A8. Unique Identifier : AIDSLINE MED/96296665; Weismann H
[The medical duty of confidentiality with patients on methadone]: Dtsch Med Wochenschr. 1996 Mar 15;121(11):351-4. Unique Identifier : AIDSLINE MED/96296671; Blank JH; Institut fur Rechtsmedizin, Klinikum, Universitat Heidelberg.
[How HIV-1 gets into the cell (news)]: Dtsch Med Wochenschr. 1996 Jul 5;121(27):A9. Unique Identifier : AIDSLINE MED/96322370; Weismann H
[Acute HIV-1 infection--an internal medicine emergency? (news)]: Dtsch Med Wochenschr. 1996 Jul 12;121(28-29):A12. Unique Identifier : AIDSLINE MED/96322371; Morike EM
[The Aids Research Prize 1996 (news)]: Dtsch Med Wochenschr. 1996 Jul 12;121(28-29):A37. Unique Identifier : AIDSLINE MED/96322372
[How does HIV-1 and other retroviruses affect the nervous system?]: Duodecim. 1995;111(9):826-35. Unique Identifier : AIDSLINE MED/96010855; Elovaara I; TAYS:n neurologian ja kuntoutustoimen yksikko, Tampere.
Changing AIDS risk behavior: effects of an intervention emphasizing AIDS risk reduction information, motivation, and behavioral skills in a college student population.: Health Psychol. 1996 Mar;15(2):114-23. Unique Identifier : AIDSLINE MED/96268949; Fisher JD; Fisher WA; Misovich SJ; Kimble DL; Malloy TE; Department of Psychology, University of Connecticut, Storrs; 06269-1020, USA. jfisher@uconnvm.uconn.edu; This research used the Information-Motivation-Behavioral Skills (IMB) model of AIDS risk behavior change (J. D. Fisher & Fisher, 1992a) to reduce AIDS risk behavior in a college student population. College students received an IMB model-based intervention that addressed AIDS risk reduction information, motivation,
Present versus future time perspective and HIV risk among heterosexual college students.: Health Psychol. 1996 Mar;15(2):131-4. Unique Identifier : AIDSLINE MED/96268951; Rothspan S; Read SJ; Department of Psychology, University of Southern California; 90089-1061, USA.; Because safer sex behaviors require planning and forethought and their primary motivations lie in the future, the hypothesis that behaviors that might reduce exposure to HIV would positively correlate with future time orientation, whereas risky behaviors would correlate with present time orientation, was tested in a s
Endocarditis caused by Arcanobacterium haemolyticum.: Eur J Clin Microbiol Infect Dis. 1995 Dec;14(12):1085-8. Unique Identifier : AIDSLINE MED/96273936; Alos JI; Barros C; Gomez-Garces JL; Servicio de Microbiologia, Hospital de Mostoles, Madrid, Spain.; A 33-year-old, active intravenous drug-abusing male infected with the human immunodeficiency virus developed endocarditis due to Arcanobacterium haemolyticum. Empirical treatment with ampicillin plus gentamicin failed to achieve a marked clinical improvement. When the results of antibiotic susceptibility were availabl
Dilated heart muscle disease associated with HIV infection.: Eur Heart J. 1995 Dec;16 Suppl O:50-5. Unique Identifier : AIDSLINE MED/96289601; Herskowitz A; Willoughby SB; Vlahov D; Baughman KL; Ansari AA; Johns Hopkins University School of Medicine, Department of; Medicine, Baltimore, Maryland, USA.; As more effective therapies have produced longer survival times for HIV-infected patients, non-infectious complications of late stage HIV infection such as the development of severe global left ventricular dysfunction (dilated heart muscle disease) have emerged. The demographic and clinical characteristics of HIV-infe
Cellular immune mechanisms in myosin-induced myocarditis.: Eur Heart J. 1995 Dec;16 Suppl O:71-4. Unique Identifier : AIDSLINE MED/96289606; Pummerer C; Grassl G; Neu N; Department of Pediatrics, Medical School, University of; Innsbruck, Austria.; Cardiac myosin-induced myocarditis proved to be a valuable virus-free murine model with which to investigate autoimmunological mechanisms in inflammatory heart disease. The disease was shown to be T cell-mediated. In this contribution the functional role of CD4 and CD8 molecules and the conditions that are required to
Decreased release of glutathione into the systemic circulation of patients with HIV infection.: Eur J Clin Invest. 1996 Jan;26(1):38-44. Unique Identifier : AIDSLINE MED/96284138; Helbling B; von Overbeck J; Lauterburg BH; Department of Clinical Pharmacology, University of Bern,; Switzerland.; Low glutathione (GSH) in patients with HIV infection could contribute to their immune deficiency since GSH plays an important role in the function of lymphocytes and sulphydryls decrease the expression of HIV in vitro. In order to gain more insight into the mechanisms responsible for the deranged sulphydryl homeostasi
My experience with 33 patients infected with HIV.: Del Med J. 1996 Feb;68(2):143-5. Unique Identifier : AIDSLINE MED/96271811; Hadjipanayis CG; Plata-Salaman CR; Jefferson Medical College of Thomas Jefferson University, USA.
The mouse Wnt-10B gene isolated from helper T cells is widely expressed and a possible oncogene in BR6 mouse mammary tumorigenesis.: Gene. 1996 Jun 26;172(2):199-205. Unique Identifier : AIDSLINE GENBANK/U30464; Hardiman G; Albright S; Tsunoda J; McClanahan T; Lee F; Department of Molecular Biology, DNAX Research Institute, Palo; Alto, CA 94304, USA. hardiman@dnax.org; From libraries made from activated mouse T lymphocytes, we have isolated cDNAs encoding Wnt-10B, a new member of the Wnt family of developmental control genes. This protein appears to be the mammalian orthologue of Wnt-10B, first identified in several non-mammalian vertebrates and recently in mouse. The mRNA expressio
[Acquired immunodeficiency syndrome--1995 (Part II)]: Harefuah. 1995 Dec 15;129(12):596-602. Unique Identifier : AIDSLINE MED/96204772; Lasry Y; Bentwich Z
c-Jun, c-Fos and their family members activate the transcription mediated by three 21-bp repetitive sequences in the HTLV-I long terminal repeat.: Intervirology. 1995;38(3-4):221-8. Unique Identifier : AIDSLINE MED/96274247; Fujii M; Tsuchiya H; Meng XB; Seiki M; Department of Molecular Virology and Oncology, Kanazawa; University, Ishikawa, Japan.; Transcription of human T-cell leukemia virus type I is regulated by a viral transactivatior Tax, through the 21-bp sequence in the long terminal repeat (LTR). We found that cellular transcription factor AP-1 (c-Jun/c-Fos heterocomplex) bound to the 21-bp sequence. The binding affinity of the complex increased in propo
Chronic progressive myeloneuropathy in WKAH rats induced by HTLV-I infection as an animal model for HAM/TSP in humans.: Intervirology. 1995;38(3-4):229-37. Unique Identifier : AIDSLINE MED/9