1996

[Extra-pulmonary pneumocystosis in the course of AIDS. Report of a case]: Ann Pathol. 1996;16(1):41-4. Unique Identifier : AIDSLINE MED/96236528; Terris B; Marche C; Potet F; Service d'Anatomie et de Cytologie Pathologiques, Hopital; Bichat-Claude Bernard, Paris.; We report a case of splenic pneumocystosis in a human immunodeficiency virus-positive individual treated prophylactically with aerosolized pentamidine. Despite this infection with Pneumocystis carinii, the bronchoalveolar lavage revealed no microorganisms. The use of aerosolized pentamidine as prophylaxis for Pneumocy
Protective immunity against HIV infection: has nature done the experiment for us?: Immunol Today. 1996 Jan;17(1):21-4. Unique Identifier : AIDSLINE MED/96226679; Shearer GM; Clerici M; National Cancer Institute, Bethesda, MD 20892, USA.; Shearerg@dc10a.nci.nih.gov
Soluble HIV-suppressive factor.: Immunol Today. 1996 Jan;17(1):3. Unique Identifier : AIDSLINE MED/96226672
Molecular mimicry: CLIP, MHC Class II supermotifs and MAIDS [letter]: Immunol Today. 1996 Jan;17(1):47-8. Unique Identifier : AIDSLINE MED/96226684; Morse HC 3rd
Ceramide, AIDS and long-term survivors [letter; comment]: Immunol Today. 1996 Jan;17(1):48. Unique Identifier : AIDSLINE MED/96226685; De Simone C; Grazia Cifone M; Roncaioli P; Moretti S; Famularo G; Alesse E; Boschini A; Testi R
Circularizing ribozymes and decoy-competitors by autocatalytic splicing in vitro and in vivo.: SAAS Bull Biochem Biotechnol. 1996;9:77-82. Unique Identifier : AIDSLINE MED/96261112; Puttaraju M; Been MD; Department of Biochemistry, Duke University Medical Center,; Durham, NC-27710, USA.; An Anabaena group I intron was circularly permuted at loop 5, loop 6 and loop 8, and tested for self-splicing activity. Precursor RNAs from these constructs spliced efficiently and produced circular exons in vitro. Using group I permuted-intron-exon sequences, circular forms of the HDV ribozyme, the RNA component of R
Biological mechanisms of HIV sexual transmission [editorial]: Ann Med. 1995 Dec;27(6):621-3. Unique Identifier : AIDSLINE MED/96262747; Milman G
HIV-1 RNA in blood and pathogenesis of HIV infection [editorial]: Ann Med. 1995 Dec;27(6):625-8. Unique Identifier : AIDSLINE MED/96262748; Saksela K
Asymptomatic atherosclerosis in HIV-positive patients: A case-control ultrasound study.: Ann Med. 1995 Dec;27(6):683-5. Unique Identifier : AIDSLINE MED/96262757; Constans J; Marchand JM; Conri C; Peuchant E; Seigneur M; Rispal P; Lasseur C; Pellegrin JL; Leng B; Service de Medecine Interne et Pathologie Vasculaire, Hopital; Saint-Andre, Bordeaux, France.; Atherosclerosis has been reported in some HIV-positive subjects without any known risk factor. The purpose of the present study was to investigate cervical arteries, abdominal aorta and femoral arteries by B-mode ultrasonography and doppler in 30 HIV-positive subjects matched to 18 controls for sex, age, tobacco consu
Cyclosporin A attenuates genetic airway hyperresponsiveness in mice but not through inhibition of CD4+ or CD8+ T cells.: Am J Respir Cell Mol Biol. 1996 Jun;14(6):627-34. Unique Identifier : AIDSLINE MED/96258776; Ewart SL; Gavett SH; Margolick J; Wills-Karp M; Department of Anesthesiology, Johns Hopkins Medical Institutions,; Baltimore, Maryland, USA.; We examined the influence of T lymphocytes on genetically determined airway hyperresponsiveness to acetylcholine (ACh) in mice. A/J and C3H/HeJ mice were treated with the T-cell suppressant cyclosporin A [(CsA) 25 to 100 mg/kg, intraperitoneally (i.p.), for 5 to 10 days], whereas control animals received the vehicle o
[Movement disorders and AIDS]: Neurologia. 1996 Feb;11(2):70-5. Unique Identifier : AIDSLINE MED/96221732; Iranzo A; Kulisevsky J; Cadafalch J; Serrano C; Grau JM; Servicio de Neurologia, Hospital de la Santa Creu i Sant Pau,; Barcelona.; We describe the clinical characteristics, causes and response to treatment in 6 patients with AIDS who presented with abnormal movement disorders between January 1987 and July 1993 in our hospital, 3 with hemiballismus-hemichorea, 1 with athetosis, 1 myoclonia and 1 with rubric tremor. Brain imaging showed lesions in
Health care and its costs for children with perinatally acquired HIV infection.: J Paediatr Child Health. 1996 Feb;32(1):42-7. Unique Identifier : AIDSLINE MED/96241664; Carlin JB; Langdon P; Hurley SF; Ziegler JB; Doherty R; Chondros P; Kaldor JM; Clinical Epidemiology and Biostatistics Unit, Royal Children's; Hospital, Parkville, Victoria, Australia.; OBJECTIVE: To describe survival patterns, use of health services and related costs for Australian children with perinatally acquired human immunodeficiency virus (HIV) infection. METHODOLOGY: A retrospective cross-sectional survey was made of 20 children with HIV infection (91% of those diagnosed) and 13 children with
The mysterious Florida AIDS mystery [letter; comment]: Br Dent J. 1996 May 25;180(10):367. Unique Identifier : AIDSLINE MED/96266740; Lim M
Sexual behaviour and condom acceptance among Nigerian drivers.: West Afr J Med. 1996 Jan-Mar;15(1):6-10. Unique Identifier : AIDSLINE MED/96250994; Araoye MO; Onile BA; Jolayemi ET; Department of Epidemiology, University of Ilorin, Nigeria.; A survey of 180 randomly selected drivers was carried out in June 1994 in Ilorin, Nigeria in order to gain information about high-risk sexual behaviours, to ascertain condom use and to identify obstacles to condom acceptance so as to facilitate the design of an intervention to pre
[Significance of PUVA therapy for adult T-cell leukemia/lymphoma--PUVA therapy can induce apoptosis in leukemic cells]: Hum Cell. 1995 Sep;8(3):121-6. Unique Identifier : AIDSLINE MED/96111291; Takemori N; Hirai K; Department of Internal Medicine, Asahikawa Kosei General; Hospital, Japan.; PUVA therapy is known to be effective for treating cutaneous T-cell lymphoma (CTCL). Considering that adult T-cell leukemia/lymphoma (ATL) represents a T-lymphocytic proliferative disorder similar to CTCL, it is likely that PUVA therapy is effective for treating ATL. We applied PUVA therapy to a 53 year old man with a
Role of methionine 184 of human immunodeficiency virus type-1 reverse transcriptase in the polymerase function and fidelity of DNA synthesis.: Biochemistry. 1996 Feb 20;35(7):2168-79. Unique Identifier : AIDSLINE MED/96194137; Pandey VN; Kaushik N; Rege N; Sarafianos SG; Yadav PN; Modak MJ; Department of Biochemistry and Molecular Biology, UMD-New Jersey; Medical School, Newark 07103, USA.; Methionine 184 of HIV-1 RT is a constituent of the catalytically crucial and highly conserved YXDD motif in the reverse transcriptase class of enzymes. We investigated the role of this residue by substituting it with Ala and Val by site-directed mutagenesis followed by extensive characterization of the two mutant enzy
Arginine-binding RNAs resembling TAR identified by in vitro selection.: Biochemistry. 1996 Feb 20;35(7):2229-38. Unique Identifier : AIDSLINE MED/96194143; Tao J; Frankel AD; Department of Biochemistry and Biophysics, University of; California, San Francisco 94143-0448, USA.; Specific binding of the human immunodeficiency virus Tat protein to its RNA site (TAR) is mediated largely by a single arginine residue located within a basic region of the protein. Many essential features of the interaction can be mimicked by the free amino acid arginine, and an NMR model has been proposed in which t
Regulation of HIV-1 protease activity through cysteine modification.: Biochemistry. 1996 Feb 20;35(7):2482-8. Unique Identifier : AIDSLINE MED/96194171; Davis DA; Dorsey K; Wingfield PT; Stahl SJ; Kaufman J; Fales HM; Levine RL; Laboratory of Biochemistry, National Heart, Lung, and Blood; Institute, National Institutes of Health, Bethesda, Maryland; 20892-0320, USA.; The homodimeric protease of the human immunodeficiency virus 1 contains two cysteine residues per monomer which are highly conserved among viral isolates. However, these cysteine residues are not essential for catalytic activity which raises the question of why they are conserved. We have found previously that these c
Socio-economic and demographic characteristics and HIV-1 infection among female commercial sex workers in Thailand.: AIDS Care. 1995;7(5):557-65. Unique Identifier : AIDSLINE MED/96263762; van Griensven GJ; Limanonda B; Chongwatana N; Tirasawat P; Coutinho RA; Department of Public Health, Municipal Health Service, Amsterdam,; Netherlands.; To identify socio-economic and demographic factors related to prevalent HIV-1 infection among female commercial sex workers (CSW) in Thailand oral interviews and blood samples were taken from 800 female commercial sex workers in northern and southern Thailand during a cross-secti
Sexual risk behaviour reduction associated with voluntary HIV counselling and testing in HIV infected patients in Thailand.: AIDS Care. 1995;7(5):567-72. Unique Identifier : AIDSLINE MED/96263763; Muller O; Sarangbin S; Ruxrungtham K; Sittitrai W; Phanuphak P; Department of Social Medicine and Epidemiology, University of; Hannover, Germany.; Sexual risk behaviour, measured by anonymously self-reported sexual activity, number of sexual partners, and condom use rates, was studied in age- and gender-matched HIV-1 positive consecutive patients from the Thai Red Cross Immune Clinic (IC) (study group, questioned after voluntary HIV counselling and testing) and
AIDS awareness among a cohort of young Thai men: exposure to information, level of knowledge, and perception of risk.: AIDS Care. 1995;7(5):573-91. Unique Identifier : AIDSLINE MED/96263764; Sweat MD; Nopkesorn T; Mastro TD; Sangkharomya S; MacQueen K; Pokapanichwong W; Sawaengdee Y; Weniger BG; Division of HIV/AIDS, National Center for Infectious Diseases,; USA.; Structured interviews and focus group discussions were conducted among 834 young Thai men drafted into military service by random lottery in northern Thailand . Level of AIDS risk, exposure to AIDS information, level of knowledge about AIDS, and perception of risk for acquiring HI
Two HIV/AIDS community support teams: patient characteristics, problems at referral and during the last 6 weeks of life.: AIDS Care. 1995;7(5):593-603. Unique Identifier : AIDSLINE MED/96263765; Butters E; Higginson I; Department of Public Health and Policy, London School of Hygiene,; UK.; Following the debate over the role and funding of specialist HIV/AIDS services there has been a call for more information about the needs of people with advanced HIV/AIDS and the processes and outcomes of care. This study describes the characteristics and problems of patients referred to two HIV/AIDS community teams i
Psychological distress among gay men supporting a lover or partner with AIDS: a pilot study.: AIDS Care. 1995;7(5):605-17. Unique Identifier : AIDSLINE MED/96263766; Irving G; Bor R; Catalan J; Department of Psychology, University of Surrey, Guildford, UK.; To date, there has been little research to examine how much psychological distress is caused to people providing care and support to a lover or partner with AIDS. This study aimed to determine the level of psychological distress experienced by a sample of gay men providing care and support to a lover or partner with A
Gay men's accounts of unsafe sex.: AIDS Care. 1995;7(5):619-30. Unique Identifier : AIDSLINE MED/96263767; Boulton M; McLean J; Fitzpatrick R; Hart G; Academic Department of Public Health, St Mary's Hospital Medical; School, London, UK.; This paper provides a qualitative analysis of the explanations given by a sample of 78 gay men in England of the most recent occasion on which they engaged in anal intercourse without a condom. Explanations are analysed and interpreted from the sociological perspective of accounts : that is, they are not viewed as ex
Heterosexually acquired HIV infection in female blood donors: case series between 1985-1990.: AIDS Care. 1995;7(5):631-8. Unique Identifier : AIDSLINE MED/96263768; McLaws ML; Learmont J; Wylie B; School of Health Services Management, University of New South; Wales, Sydney, Australia.; The case histories aimed to describe the risk behaviours of a series of seven Australian women who acquired the human immunodeficiency virus (HIV) through heterosexual contact. Between 1985 and 1990 eight HIV antibody positive female donors were identified through routine HIV antibody screening at the NSW Red Cross Bl
The vaginal use of herbs/substances: an HIV transmission facilitatory factor?: AIDS Care. 1995;7(5):639-45. Unique Identifier : AIDSLINE MED/96263769; Runganga AO; Kasule J; Obstetric & Gynaecology Department, University of Zimbabwe,; Harare, Zimbabwe.; Heterosexual intercourse accounts for 80% of HIV transmission in sub-Saharan Africa. Factors facilitating cross-infection may include sexual practices such as the vaginal use of herbs/substances to dry, contract and heat the vagina for enhancement of sexual pleasure. The behavioural-analytic study investigated the use
Determinants of HIV risk among men who have homosexual sex and inject drugs.: AIDS Care. 1995;7(5):647-55. Unique Identifier : AIDSLINE MED/96263770; Crofts N; Marcus L; Meade J; Sattler G; Wallace J; Sharp R; Macfarlane Burnet Centre for Medical Research, Fairfield,; Victoria, Australia.; Men with histories of both homosexual contact and injecting drug use (IDU) are at increased risk of HIV infection over men who have only one such risk. Despite this, their special needs and circumstances have been neglected by AIDS prevention programmes. A survey of a wide spectrum of homosexual male IDUs was carried
Vertical transmission of HIV--a rediscussion of testing.: AIDS Care. 1995;7(5):657-62. Unique Identifier : AIDSLINE MED/96263771; Macquart-Moulin G; Hairion D; Auquier P; Manuel C; INSERM Research Unit, Institut Paoli-Calmettes, Marseille,; France.; It is worthwhile reconsidering the debate on mandatory or voluntary testing for HIV antibody among women of childbearing age, in the light of recent virological and therapeutic discoveries that have altered the parameters of the issue. The therapeutic possibilities of reducing the risk of transmission for women confir
Developing AIDS care in Zimbabwe: a case for residential community centres?: AIDS Care. 1995;7(5):663-73. Unique Identifier : AIDSLINE MED/96263772; Jackson H; Kerkhoven R; Southern Africa AIDS Information Dissemination Service, Harare,; Zimbabwe.; New support services are needed as the AIDS epidemic escalates. Home care has been the cornerstone of new developments in Zimbabwe and the southern African region, essentially resource-strapped countries. However, while home care has many benefits, levels of coverage are often lo
WHO global AIDS statistics. AIDS cases reported to the World Health Organization as at 7 July 1995.: AIDS Care. 1995;7(5):689-90. Unique Identifier : AIDSLINE MED/96263773
Oral ganciclovir: a new option for patients with CMV retinitis [editorial]: Int J STD AIDS. 1996 Jan-Feb;7(1):1-3. Unique Identifier : AIDSLINE MED/96228416; Fisher M; Barton S; Cytomegalovirus retinitis is a major cause of morbidity in patients with AIDS. The conventional treatment approach has involved insertion of a central venous catheter and intravenous administration of ganciclovir and/or foscarnet. This has been associated with systemic toxicity, line-related sepsis, and implications f
Vulval intraepithelial neoplasia [editorial]: Int J STD AIDS. 1996 Jan-Feb;7(1):10-3. Unique Identifier : AIDSLINE MED/96228419; Jebakumar S; Woolley PD; Bhattacharyya MN
Uses and limitations of gonococcal serotyping [editorial]: Int J STD AIDS. 1996 Jan-Feb;7(1):14-8. Unique Identifier : AIDSLINE MED/96228420; Ross JD
Tests for infection with Chlamydia trachomatis.: Int J STD AIDS. 1996 Jan-Feb;7(1):19-25; quiz 26. Unique Identifier : AIDSLINE MED/96228421; Taylor-Robinson D; Department of Genitourinary Medicine, St Mary's Hospital,; Paddington, London, UK.
The radiological manifestations of the acquired immune deficiency syndrome--Part 1.: Int J STD AIDS. 1996 Jan-Feb;7(1):27-31. Unique Identifier : AIDSLINE MED/96228422; Banerjee AK; Birmingham Heartlands Hospital (Teaching), Bordesley Green East,; UK.
Case-control study of sexually transmitted diseases as cofactors for HIV-1 transmission.: Int J STD AIDS. 1996 Jan-Feb;7(1):34-8. Unique Identifier : AIDSLINE MED/96228423; Beck EJ; Mandalia S; Leonard K; Griffith RJ; Harris JR; Miller DL; Academic Department of Public Health, St Mary's Hospital and; Medical School, London, UK.; The aim of the study was to investigate the association between infection with HIV-1 infection and a history of other sexually transmitted diseases (STD). We were able to match 1295 HIV-1 infected patients who attended St Mary s Hospital between 1985 and 1991 with 1273 seronegative controls on gender, sexual orientati
Judging a book by its cover: gay men's use of perceptible characteristics to infer antibody status.: Int J STD AIDS. 1996 Jan-Feb;7(1):39-43. Unique Identifier : AIDSLINE MED/96228424; Gold RS; Skinner MJ; School of Psychology, Deakin University, Victoria, Australia.; This study investigated gay men s use of perceptible characteristics to infer antibody status. Participants (n = 66) read brief descriptions of men they did not know and estimated the likelihood that they were HIV-infected. Each description highlighted one of 6 characteristics: physical attractiveness, intelligence/ed
Sexually transmissible agent and African Kaposi's sarcoma [editorial]: Int J STD AIDS. 1996 Jan-Feb;7(1):4-6. Unique Identifier : AIDSLINE MED/96228417; Matondo P; Sivapalan S; Kaposi s sarcoma (KS) has a higher incidence in some parts of Africa than anywhere else in the world. Recent studies in western homosexual men with AIDS-KS suggest that KS may be caused by a putative sexually transmissible agent. Our analytical review of studies on KS in Africa before and during the AIDS era reveals a
AIDS defining conditions in Africans resident in the United Kingdom.: Int J STD AIDS. 1996 Jan-Feb;7(1):44-7. Unique Identifier : AIDSLINE MED/96228425; Del Amo J; Goh BT; Forster GE; Ambrose King Centre, Department of Genitourinary Medicine, Royal; London Hospital, Whitechapel, UK.; A retrospective study of 55 HIV-1 seropositive African patients living in the UK, seen between January 1986 and November 1993, showed a total of 26 (47%) patients with AIDS. Thirty-one (56%) had symptomatic HIV disease at the time of presentation of whom 19 (34.5%) had an AIDS defining condition. Tuberculosis was the
Increasing trend of HIV seropositivity in a sexually transmitted diseases centre and epidemiology of HIV seropositive individuals.: Int J STD AIDS. 1996 Jan-Feb;7(1):48-50. Unique Identifier : AIDSLINE MED/96228426; Ray K; Ramesh V; Karmakar SN; Misra RS; Regional Sexually Transmitted Diseases Teaching, Training and; Research Centre, Safdarjang Hospital, New Delhi, India.; 11,539 STD clinic attenders and 20,897 antenatal clinic (ANC) attenders at a New Delhi hospital were screened for HIV antibodies by ELISA over a 3-year period. Results were confirmed by Western Blot. A low HIV seropositivity rate (1 per 1000) with an increasing trend in 1993 (4 per 1000) was observed in the STD attend
The effects of peer education on STD and AIDS knowledge among prisoners in Mozambique.: Int J STD AIDS. 1996 Jan-Feb;7(1):51-4. Unique Identifier : AIDSLINE MED/96228427; Vaz RG; Gloyd S; Trindade R; National Institute of Health, Ministry of Health, Maputo,; Mozambique,; The study was designed to evaluate the impact of education on AIDS knowledge among prison inmates in Maputo, Mozambique . A 6-month follow-up study was carried out in 1993 among 300 prisoners. A knowledge, attitudes, and practices questionnaire regarding AIDS and STD was adminis
Autoimplantation technique in the treatment of anogenital warts: a clinico-immunological study.: Int J STD AIDS. 1996 Jan-Feb;7(1):55-7. Unique Identifier : AIDSLINE MED/96228428; Usman N; Udayashankar K; Subramanian S; Thyagarajan SP; Department of Sexually Transmitted Diseases, Government Stanley; Hospital, Madras, India.; An autoimplantation technique was adopted in the treatment of 50 cases of anogenital warts and was compared with the conventionally used podophyllin regimen in a matched group of 50 patients. They were assessed with 15 untreated subjects in a control group for the rate of clinical cure after 6 weeks, recurrence after
Undernotification of tuberculosis in patients with AIDS.: Int J STD AIDS. 1996 Jan-Feb;7(1):58-60. Unique Identifier : AIDSLINE MED/96228429; Balogun MA; Wall PG; Noone A; Parkside Health Authority, London, UK.; The purpose of this study was to establish the extent of undernotification of tuberculosis in AIDS patients resident in 2 inner London local authorities. For residents of the 2 authorities, statutory notifications of tuberculosis between 1986 and 1992 were compared, using soundex codes of surnames, sex and year of bir
Coinfection with chlamydia and gonorrhoea among pregnant women and bacterial vaginosis.: Int J STD AIDS. 1996 Jan-Feb;7(1):61-4. Unique Identifier : AIDSLINE MED/96228430; Joesoef MR; Wiknjosastro G; Norojono W; Sumampouw H; Linnan M; Hansell MJ; Hillis SE; Lewis J; Division of STDHIV Prevention, Centers for Disease Control and; Prevention, Atlanta, Georgia, USA.; The role of sexual transmission of microorganisms in bacterial vaginosis (BV) is controversial. If sexual intercourse were a risk factor for BV, then we would expect that women with BV would also be coinfected with other sexually transmitted diseases (STD). We investigated the prevalence of STD among pregnant women a
Contraceptive use and HIV infection in Kenyan family planning clinic attenders.: Int J STD AIDS. 1996 Jan-Feb;7(1):65-70. Unique Identifier : AIDSLINE MED/96228431; Sinei SK; Fortney JA; Kigondu CS; Feldblum PJ; Kuyoh M; Allen MY; Glover LH; Department of Obstetrics and Gynaecology, University of Nairobi,; Kenya.; This pilot study aimed to determine the feasibility of a larger study of contraception and risk of HIV infection in women. We also measured risk factors for and occurrence of HIV infection in the participants. A cohort of 1537 seronegative women attending a family planning clinic in Nairobi,
Syphilis makes a comeback [editorial]: Int J STD AIDS. 1996 Jan-Feb;7(1):7-9. Unique Identifier : AIDSLINE MED/96228418; Drusin LM
Azithromycin in sexually transmitted diseases.: Int J STD AIDS. 1996;7 Suppl 1:1. Unique Identifier : AIDSLINE MED/96230310; Ridgway GL; University College London Hospitals, London, UK.
Treatment of syphilis with azithromycin.: Int J STD AIDS. 1996;7 Suppl 1:13-5. Unique Identifier : AIDSLINE MED/96230314; Mashkilleyson AL; Gomberg MA; Mashkilleyson N; Kutin SA; Semashko Moscow Medical School, Russia.; The efficacy of oral azithromycin (500 mg daily for 10 days or 500 mg on alternate days for 11 days) in 100 patients with seropositive syphilis was studied. Clinical manifestations regressed more rapidly in azithromycin-treated patients compared with patients who received erythromycin or penicillin, and there was also
Azithromycin in the management of opportunistic infections.: Int J STD AIDS. 1996;7 Suppl 1:17. Unique Identifier : AIDSLINE MED/96230315; Young LS; Kuzell Institute for Infectious Diseases and Arthritis, San; Francisco, USA.
The potential role of azithromycin in the treatment of prophylaxis of toxoplasmosis.: Int J STD AIDS. 1996;7 Suppl 1:18-22. Unique Identifier : AIDSLINE MED/96230316; Chang HR; Department of Microbiology, Faculty of Medicine, National; University of Singapore, Singapore.; Infection with Toxoplasma gondii is the most common parasitic infection worldwide with an estimated prevalence of 1-2 billion people. The risk of developing severe toxoplasmosis is higher for immunocompromised individuals and fetuses of mothers who have acquired a primo-infection. The current therapy of choice for tox
Azithromycin in gonorrhoea.: Int J STD AIDS. 1996;7 Suppl 1:2-4. Unique Identifier : AIDSLINE MED/96230311; Waugh MA; Leeds General Infirmary, UK.; The clinical applications of azithromycin in gonorrhoea, often complicated by simultaneously acquired infection with Chlamydia trachomatis, are reviewed in this paper. Clinical trails from major centres in Europe are compared with a large, more recent US study. At the present time, azithromycin is recommended througho
Treatment and prophylaxis of Mycobacterium avium complex.: Int J STD AIDS. 1996;7 Suppl 1:23-7. Unique Identifier : AIDSLINE MED/96230317; Young LS; Kuzell Institute for Arthritis & Infectious Diseases, California; Pacific Medical Center, San Francisco, USA.; The most common pathogens involved in disseminated bacterial infection in people with acquired immunodeficiency syndrome (AIDS) are organisms of the Mycobacterium avium-intracellulare complex (MAC). Azithromycin and clarithromycin, a new azalide and macrolide, respectively, are among the most potent monotherapies for
Human cryptosporidiosis.: Int J STD AIDS. 1996;7 Suppl 1:28-33. Unique Identifier : AIDSLINE MED/96230318; Hoepelman IM; Department of Medicine, Eijkman Winkler Laboratory for Medical; Microbiology, University Hospital, Utrecht, The Netherlands.; Cryptosporidium parvum is a protozoan which can cause severe debilitating disease in immunocompromised individuals. Animal models have shown that cellular immunity is the most important factor against the development of the disease. Individuals with a humoral immune deficiency are also at risk. In HIV-infected patient
Azithromycin in the prophylaxis of opportunistic infections in AIDS.: Int J STD AIDS. 1996;7 Suppl 1:34-7. Unique Identifier : AIDSLINE MED/96230319; McCutchan JA; UCSD Treatment Center, Department of Medicine, San Diego,; California, USA.; Prevention of opportunistic infections contributes to improved quality of life and survival in individuals with acquired immunodeficiency syndrome (AIDS). Agents which are more effective and convenient, less costly, and better tolerated are needed for multiple organism primary prophylaxis. Azithromycin, azalide with h
Azithromycin in the management of Chlamydia trachomatis infections.: Int J STD AIDS. 1996;7 Suppl 1:5-8. Unique Identifier : AIDSLINE MED/96230312; Ridgway GL; Department of Clinical Microbiology, University College London; Hospitals, UK.; The unique pharmacological profile of the azalide macrolide azithromycin, coupled with its in vitro activity against both Chlamydia trachomatis and the ureaplasmas, suggested that genital infections caused by these bacteria could be successfully treated with a single dose of the antibiotic. This has now been confirmed
Treatment of chancroid with azithromycin.: Int J STD AIDS. 1996;7 Suppl 1:9-12. Unique Identifier : AIDSLINE MED/96230313; Ballard RC; Ye H; Matta A; Dangor Y; Radebe F; National Reference Centre for Sexually Transmitted Diseases,; South African Institute for Medical Research, Johannesburg, South; Africa.; A randomized, comparative study undertaken in Nairobi, Kenya and a non-comparative evaluation undertaken in Carletonville, South Africa have both shown that a single oral dose of azithromycin 1 g is effective in the treatment of the genital ulce
[Comments on the position of Sibrowski et al. on the comment by v. Bormann et al.: autologous blood is safer than donated blood--fact or fiction? (letter)]: Anasthesiol Intensivmed Notfallmed Schmerzther. 1996 Mar;31(2):120. Unique Identifier : AIDSLINE MED/96204159; Lorentz A; Tolksdorf B; Becker P
Kaposi's sarcoma-associated herpesvirus (KSHV or HHV8) in primary effusion lymphoma: ultrastructural demonstration of herpesvirus in lymphoma cells.: Blood. 1996 Jun 15;87(12):4937-43. Unique Identifier : AIDSLINE MED/96247494; Said W; Chien K; Takeuchi S; Tasaka T; Asou H; Cho SK; de Vos S; Cesarman E; Knowles DM; Koeffler HP; Department of Pathology, Cedars Sinai Medical Center, Los; Angeles, CA 90048, USA.; Recent molecular evidence suggests an association with a new herpesvirus, Kaposi s sarcoma-associated herpesvirus (KSHV/HHV-8), and primary effusion lymphomas (PELs). PELs have a characteristic morphology, phenotype, and clinical presentation, with malignant effusions in the absence of a contiguous solid tumor mass. W
Fas-mediated apoptosis of CD4+ and CD8+ T cells from human immunodeficiency virus-infected persons: differential in vitro preventive effect of cytokines and protease antagonists.: Blood. 1996 Jun 15;87(12):4959-66. Unique Identifier : AIDSLINE MED/96247497; Estaquier J; Tanaka M; Suda T; Nagata S; Golstein P; Ameisen JC; Inserm U415, Lille, France.; Human immunodeficiency syndrome (HIV) infection leads to a progressive loss of T-cell-mediated immunity associated with T-cell apoptosis. We report here that CD4+ and CD8+ T cells from HIV-1-infected persons are sensitive to Fas (CD95/APO-1)-mediated death induced either by an agonistic anti-Fas antibody or by the phy
Single human T cells stimulated in the absence of feeder cells transcribe interleukin-2 and undergo long-term clonal growth in response to defined monoclonal antibodies and cytokine stimulation.: Blood. 1996 Jun 15;87(12):5179-84. Unique Identifier : AIDSLINE MED/96247520; Sunder-Plassmann R; Breiteneder H; Zimmermann K; Strunk D; Majdic O; Knapp W; Holter W; Institute of Immunology, University of Vienna, Austria.; The two-signal model of T-cell activation postulates that T lymphocytes require at least two distinct signals for activation. This model has been established with bulk cultures of T cells in which T-cell-T-cell interaction can occur, possibly delivering further unrecognized costimulatory signals. The signal requiremen
Antiphosphatidylserine antibodies in human immunodeficiency virus-1 patients with evidence of T-cell apoptosis and mediate antibody-dependent cellular cytotoxicity.: Blood. 1996 Jun 15;87(12):5185-95. Unique Identifier : AIDSLINE MED/96247521; Silvestris F; Frassanito MA; Cafforio P; Potenza D; Di Loreto M; Tucci M; Grizzuti MA; Nico B; Dammacco F; Department of Biomedical Sciences and Human Oncology, University; of Bari, Medical School, Bari, Italy.; Serum reactivities to a panel of phospholipid antigens, including cardiolipin (CL), phosphatidylserine (PS), sphingomyelin, phosphatidylcholine, and phosphatidylethanolamine, were measured by enzyme-linked immunosorbent assay in 196 human immunodeficiency virus-l+ (HIV-1+) patients with CDC II to IVC clinical disease.
[HIV infections in Germany (editorial)]: Bildgebung. 1995 Dec;62(4):242-3. Unique Identifier : AIDSLINE MED/96227393; Goebel FD
[Endoscopy of the upper gastrointestinal tract in HIV disease]: Bildgebung. 1995 Dec;62(4):244-51. Unique Identifier : AIDSLINE MED/96227394; Caca K; Zietz C; Bogner JR; Goebel FD; Zoller WG; Klinikum Innenstadt, Ludwig-Maximilians-Universitat Munchen,; Deutschland.; Gastrointestinal (GI) symptoms are part of the most frequent complaints in HIV disease. A methodical effort is required to identify treatable syndromes. Progressive immunodeficiency is associated with increased prevalence of opportunistic or non-opportunistic infections and neoplasms. Dysphagia and odynophagia, in the
[HIV infection and the lower gastrointestinal tract--characteristics of endoscopic diagnosis]: Bildgebung. 1995 Dec;62(4):252-8. Unique Identifier : AIDSLINE MED/96227395; Mauss S; Borchard F; Jablonowski H; Niederau C; Klinik fur Gastroenterologie, Hepatologie und Infektiologie,; Heinrich-Heine-Universitat, Dusseldorf, Deutschland.; In the course of HIV infection intestinal complaints, particularly diarrhoea, are frequent. As a result of the HIV-induced immunosuppression infections with unusual viral, mycobacterial and protozoan pathogens occur. In addition usually self-limiting intestinal infections become frequently persistent in HIV-positive p
[HIV infection: findings in liver and bile ducts]: Bildgebung. 1995 Dec;62(4):260-70. Unique Identifier : AIDSLINE MED/96227396; Jablonowski H; Klinik fur Gastroenterologie, Hepatologie und Infektiologie,; Heinrich-Heine-Universitat, Dusseldorf, Deutschland.; Gastrointestinal diseases in HIV-infected patients mainly affect the bowel, the oesophagus, and the liver. Most of the hepatic diseases are due to opportunistic infections and associated to AIDS. In the advanced AIDS disease Mycobacterium avium intracellulare is the most frequent bacterial infections agent. Mycobacter
[Ultrasound findings in HIV patients]: Bildgebung. 1995 Dec;62(4):271-80. Unique Identifier : AIDSLINE MED/96227397; Luthen R; Niederau C; Klinik fur Gastroenterologie, Hepatologie und Infektiologie,; Heinrich-Heine-Universitat, Dusseldorf, Deutschland.; A wide range of abnormal findings can be seen at abdominal ultrasonography in patients with HIV infection. The most frequent findings, hepatomegaly, splenomegaly, and enlarged lymph nodes, are nonspecific, however. Increased echogenicity or focal lesions of parenchymal organs, dilated bile ducts, nephromegaly, gut wal
[Ultrasound skin findings in HIV infection by imaging with 7.5 MHz linear transducers]: Bildgebung. 1995 Dec;62(4):281-6. Unique Identifier : AIDSLINE MED/96227398; Bogner JR; Rocken M; Medizinische Poliklinik, Universitat Munchen, Deutschland.; Sonography is an important tool in aiding the diagnosis of tumor-like and cystic findings in the skin and soft tissues. This is also true in patients with HIV infection and AIDS. While sonography of the skin often is performed with 20-MHz transducers, also lower-frequency devices which are more readily available contr
[AIDS: infections of the retina and choroid]: Bildgebung. 1995 Dec;62(4):288-301. Unique Identifier : AIDSLINE MED/96227399; Schimkat M; Althaus C; Augenklinik der Medizinischen, Einrichtungen der; Heinrich-Heine-Universitat Dusseldorf, Deutschland.; Various viral, bacterial, parasitic and fungal agents have been found to cause infections of retina and choroidea in HIV-infected patients. Usually these infections are opportunistic infections caused by the profound immunodeficiency, which is a result of the decay of lymphocytes by HIV. Before the HIV epidemic only r
[Differential radiologic diagnosis of HIV-associated lung diseases]: Bildgebung. 1995 Dec;62(4):302-9. Unique Identifier : AIDSLINE MED/96227400; Becker-Gaab C; Kuffer G; Kammer B; Bogner JR; Institut fur Radiologische Diagnostik,; Ludwig-Maximilians-Universitat, Munchen, Deutschland.; In 1993 in Germany an estimated number of 50,000-70,000 individuals were infected with the human immunodeficiency virus (HIV), WHO estimations ranged up to 14 million HIV-positive individuals including 1 million children. AIDS-related diseases frequently occur in the lung. 65% of
Imaging methods as a diagnostic tool in neuro-AIDS. A review.: Bildgebung. 1995 Dec;62(4):310-9. Unique Identifier : AIDSLINE MED/96227401; Arendt G; Neurologische Klinik, Universitat Dusseldorf, Germany.; Since 1983, central nervous system (CNS) involvement in acquired immune deficiency syndrome (AIDS) is well recognized. Imaging methods are important in diagnosing AIDS-related primary and secondary CNS processes as HIV-1-associated encephalopathy, cerebral toxoplasmosis, primary CNS ly
Intensification of donor interviewing procedures: a feasibility study.: Infusionsther Transfusionsmed. 1996 Feb;23(1):32-4. Unique Identifier : AIDSLINE MED/96220386; van Rhenen DJ; Molijn MH; Gorgels J; van der Linden JM; Ko LK; Red Cross Blood Bank Rotterdam, The Netherlands.; OBJECTIVE: To determine the feasibility and acceptability for the blood donor of an intensified blood donor interviewing procedure on high-risk factors for infectious diseases. To answer the question whether an intensified blood donor interviewing procedure would lead to an unacceptable loss of blood donors. DESIGN: F
[Importance of introduction of PCR in blood banks (editorial)]: Infusionsther Transfusionsmed. 1996 Feb;23(1):4-6. Unique Identifier : AIDSLINE MED/96220381; Gurtler L
Impending flu pandemic [news]: Can Fam Physician. 1996 Apr;42:805-7. Unique Identifier : AIDSLINE MED/96225151; Kermode-Scott B
Chronic care. The military's assault on AIDS.: Hosp Health Netw. 1996 Jul 5;70(13):38. Unique Identifier : AIDSLINE MED/96283616; MacPherson P
AIDS and HIV-1 infection worldwide.: Commun Dis Rep CDR Wkly. 1996 May 17;6(20):179-80. Unique Identifier : AIDSLINE MED/96250775
Using administratively collected hospital discharge data for AIDS surveillance.: Ann Epidemiol. 1995 Sep;5(5):337-46. Unique Identifier : AIDSLINE MED/96113142; Payne SM; Seage GR 3rd; Oddleifson S; Gallagher K; vanBeuzekom M; Losina H; Hertz T; Health Services Department, Boston University School of Public; Health, MA 02118, USA.; The objectives of this study were twofold: to improve methods of identifying possible and acquired immunodeficiency syndrome (AIDS)-related hospital discharges in administrative databases and to measure AIDS-reporting completeness in Massachusetts both overall and by subgroup. We used fiscal year 1988 discharge data f
The value of the lymphocyte proliferation test with phytohemagglutinin in the immune evaluation of Brazilian HIV-infected patients.: J Investig Allergol Clin Immunol. 1995 Nov-Dec;5(6):347-9. Unique Identifier : AIDSLINE MED/96246788; Casseb JS; Benard G; Saito R; Brigido LF; Tanaami D; Joaquim ES; Duarte AJ; Immunogenetic and Experimental Transplantation Laboratory,; University of Sao Paulo, Brazil.; We evaluated phytohemagglutinin (PHA) lymphocyte proliferation and delayed-type hypersensitivity tests in 130 Brazilian HIV-infected patients with the objective of assessing the value of these tests in staging HIV infection. Patients were divided into three groups according to their CD4+ cell counts (cells/mm3):
Importance of human immunodeficiency virus-associated lymphadenopathy and tuberculous lymphadenitis in patients undergoing lymph node biopsy in Zambia.: Br J Surg. 1996 Jan;83(1):75-8. Unique Identifier : AIDSLINE MED/96264054; Bem C; Patil PS; Bharucha H; Namaambo K; Luo N; School of Medicine, University of Zambia, Republic of Zambia.; The relative importance of human immunodeficiency virus (HIV)-associated lymphadenopathy amongst patients presenting for lymph node biopsy in Central Africa is unknown. HIV-1 serology and histology of patients undergoing superficial lymph node biopsy during 1989-1990 in Lusaka, Zambia
Changes in dentists' infection control practices, knowledge, and attitudes about HIV over a 2-year period.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996 Mar;81(3):297-302. Unique Identifier : AIDSLINE MED/96252799; McCarthy GM; Koval JJ; Faculty of Dentistry, University of Western Ontario, London,; Canada.; OBJECTIVE. To investigate changes in the infection control practices, attitudes, and knowledge of dentists as they relate to HIV/AIDS. STUDY DESIGN. A comparison of responses to surveys conducted in 1992 (n = 258) and 1994 (n = 262) with the use of univariate/multivariate analyses and McNemar s test for paired data. R
New nucleoside analogue, lamivudine, released for HIV therapy [news]: Am J Health Syst Pharm. 1996 Jan 15;53(2):116. Unique Identifier : AIDSLINE MED/96263409
Doxorubicin liposome formulation gains marketing approval [news]: Am J Health Syst Pharm. 1996 Jan 15;53(2):116, 119. Unique Identifier : AIDSLINE MED/96263410
Antisense strategies and therapeutic applications.: Am J Health Syst Pharm. 1996 Jan 15;53(2):151-60; quiz 182-3. Unique Identifier : AIDSLINE MED/96263414; Putnam DA; Department of Pharmaceutics and Pharmaceutical Chemistry,; University of Utah, Salt Lake City, UT 84112, USA.; The concepts underlying the antisense approach to disease therapy are discussed, and potential applications are examined. Antisense therapeutic agents bind to DNA or RNA sequences, blocking the synthesis of cellular proteins with unparalleled specificity. Transcription and translation are the two processes with which
[Nervous system infections by retroviruses]: Rev Neurol. 1996 Jun;24(130):703-7. Unique Identifier : AIDSLINE MED/96244171; Roman GC; Institutos Nacionales de Salud de los EE. UU, Universidad de; Tejas en San Antonio, USA.
[The Bratislava International Eye Bank--a member of the International Federation of Eye Banks]: Cesk Slov Oftalmol. 1996 Feb;52(1):34-8. Unique Identifier : AIDSLINE MED/96213459; Cernak A; Galikova M; Ocna klinika IVZ, Bratislava.; The International Eye Bank in Bratislava has assembled during its two-year activities 1007 corneae with a 2mm scleral margin by excision performed in the donor in situ, 11 total eye-balls and 43 sclerae. From this total number 1331 eye tissues had to be eliminated because of serum positivity (115 HBsAg, 12 HCV, 2 HIV
Collaborative care receives stamp of approval in CMA, CNA study involving HIV/AIDS.: Can Med Assoc J. 1996 Jun 15;154(12):1898-9. Unique Identifier : AIDSLINE MED/96258836; Walters D; Morgan D; Colbran-Smith M; The CMA wants to work with national health care groups, such as the Canadian Nurses Association (CNA), to explore ways providers can work collaboratively to provide quality health care. A joint working group of the CMA and the CNA recently examined collaborative care, focusing on examples provided in HIV/AIDS care. Th
Lower lung field tuberculosis in Yaounde, Cameroon.: Cent Afr J Med. 1996 Mar;42(3):62-5. Unique Identifier : AIDSLINE MED/96250764; Kuaban C; Fotsin JG; Koulla-Shiro S; Ekono MR; Hagbe P; Department of Internal Medicine, Faculty of Medicine and; Biomedical Sciences, University of Younde 1/Jamot Hospital; Younde, Cameroon.; Lower lung field tuberculosis was investigated in 273 consecutive adult patients with pulmonary tuberculosis admitted into the Chest Unit of the Jamot Hospital in Yaounde from December 1991 to July 1992. Twenty eight cases were found representing 10.3 pc of the total admissions with pulmonary tuberculosis. Twenty thre
HTLV-I infection in the Free State region of South Africa: a sero-epidemiologic study.: Cent Afr J Med. 1996 Mar;42(3):65-8. Unique Identifier : AIDSLINE MED/96250765; van der Ryst E; Joubert G; Smith MS; Terblanche M; Mollentze F; Pretorius AM; Department of Virology, University of the Orange Free State,; Bloemfotein, South Africa.; Human T-lymphotropic virus type I (HTLV-1) is associated with tropical spastic paraparesis (TSP) and adult T-cell leukemia/lymphoma. HTLV-I infection is endemic in certain parts of the Natal/KwaZulu region of South Africa . No studies on the seroprevalence of HTLV-I infection in th
Reproductive and sexual health: a research and developmental challenge.: Cent Afr J Med. 1996 Mar;42(3):80-5. Unique Identifier : AIDSLINE MED/96250771; Mbizvo MT; Department of Obstetrics and Gynaecology, University of Zimbabwe,; Harare, Zimbabwe.; There is a growing awareness of the burden and implications of reproductive ill health as contributed by unsafe motherhood (during pregnancy, childbirth, abortion), reproductive tract infection (RTIs) and cancer, sexually transmitted infections (STIs) including the human immunodeficiency virus (HIV), poorly regulated
Leishmaniasis in AIDS patients: results of leukocytoconcentration, a fast biological method of diagnosis.: Bull World Health Organ. 1996;74(1):91-3. Unique Identifier : AIDSLINE MED/96267283; Izri MA; Deniau M; Briere C; Rivollet D; Petithory JC; Houin R; Rousset JJ; Laboratory of Parasitology, Hopital Avicenne, Bobigny, France.; Leukocytoconcentration is an easy, fast and inexpensive technique for the diagnosis of leishmaniasis from peripheral blood. The technique involves concentration of blood parasites on a small surface of a microscope slide while the red blood cells are removed by lysis. The results, compared with those of other methods
Fluorometric detection of HIV-1 genome through use of an internal control, inosine-substituted primers, and microtiter plate format.: Clin Chem. 1996 May;42(5):696-703. Unique Identifier : AIDSLINE MED/96211420; Gerard B; Peponnet C; Brunie G; Cave H; Denamur E; d'Auriol L; Monplaisir N; Simon F; Elion J; Grandchamp B; Service de Biochimie Genetique, Hopital Robert Debre, Paris,; France.; We describe a PCR-based fluorometric assay for the detection of the HIV-1 genome. This technique consists of a reverse hybridization with oligonucleotide probes covalently coated onto a microtiter plate as a solid support. Several improvements to the PCR amplification and detection steps gave greater sensitivity and s
Human immunodeficiency virus and the orthopaedic surgeon.: Clin Orthop. 1996 Jul;(328):31-3. Unique Identifier : AIDSLINE MED/96266877; Hamilton JB; Department of Orthopaedic Surgery and Haematology, Bradford; Hospitals, Bradford, United Kingdom.; Human immunodeficiency virus is a devastating disease that ends in death. The fear that it engenders in healthworkers and patients may be out of proportion to the risks involved but an emotional response to the dangers is understandable. However, a careful study of the risks, the adoption of high standards of practice
Long term evaluation of septic arthritis in hemophilic patients.: Clin Orthop. 1996 Jul;(328):54-9. Unique Identifier : AIDSLINE MED/96266881; Gilbert MS; Aledort LM; Seremetis S; Needleman B; Oloumi G; Forster A; Department of Orthopedics, Mount Sinai Hospital, New York, NY,; USA.; Before 1983, septic arthritis was rare in patients with hemophilia. With the advent of human immunodeficiency virus infection in the hemophilia population, many centers noted an increasing incidence of patients with septic arthritis. Fifteen septic joints in 10 patients with severe hemophilia were documented. Eight pa
Intraocular silicone oil for retinal detachment in AIDS: CT and MR appearances.: Clin Radiol. 1996 Jun;51(6):415-7. Unique Identifier : AIDSLINE MED/96262157; Murray JG; Gean AD; Barr RM; Department of Radiology, San Francisco General Hospital, USA.; AIM: To describe the CT and MR features of intraocular silicone oil which is used to treat complex retinal detachments in patients with acquired immune deficiency syndrome (AIDS). PATIENTS AND METHODS: Seven male patients with AIDS were treated by pars plana vitrectomy and intraocular silicone oil injection for comple
Unusual cause of fever and diarrhea in a patient with AIDS. Penicillium marneffei infection.: Dig Dis Sci. 1996 Jun;41(6):1212-5. Unique Identifier : AIDSLINE MED/96258878; Leung R; Sung JY; Chow J; Lai CK; Department of Medicine, Prince of Wales Hospital, Shatin, Hong; Kong.; Penicillium marneffei is an opportunistic pathogen predominantly found in Southeast Asia. Systemic infection of Penicillium marneffei has protean manifestations including fever, weight loss, anaemia, skin lesions, and lymphadenopathy. We report a rare case of penicillium colitis in an AIDS patient who responded succes
Effect of human immunodeficiency virus infection on hepatitis C virus infection in hemophiliacs.: Dig Dis Sci. 1996 Jun;41(6):1265-72. Unique Identifier : AIDSLINE MED/96258886; Ghany MG; Leissinger C; Lagier R; Sanchez-Pescador R; Lok AS; Department of Medicine, Tulane University School of Medicine, New; Orleans, Louisiana, USA.; Chronic liver disease due to hepatitis C virus (HCV) infection is a major problem in hemophiliacs. Recent reports suggested that hemophiliacs coinfected with hepatitis C virus and human immunodeficiency virus (HIV) have an increased incidence of liver failure but the mechanism of accelerated liver injury is not clear.
[Prevalence of Cryptosporidium sp and Isospora belli in patients with acquired immunodeficiency syndrome (AIDS) in Dakar (Senegal]: Dakar Med. 1994;39(2):121-4. Unique Identifier : AIDSLINE MED/96220614; Dieng T; Ndir O; Diallo S; Coll-Seck AM; Dieng Y; Service de Parasitologie-Mycologie, Faculte de Medecine et de; Pharmacie, Dakar.; 72 patients with AIDS, having diarrhoea and admitted in the Unit of Infectious diseases, Fann Hospital from 1989 to 1991 were investigated for Cryptosporidium sp. and Isospora belli isolation by the modified Ziehl-Neelsen technique, after stolls concentration by Ritchie technique. The prevalence were 13.9% for Crypto
Nerve conduction changes in asymptomatic HIV-1 seropositive individuals in the absence of other risk factors for neuropathy.: Electromyogr Clin Neurophysiol. 1996 Jan-Feb;36(1):3-8. Unique Identifier : AIDSLINE MED/96244706; Malessa R; Agelink M; Himmelmann M; Kloss T; Mertins L; Brockmeyer NH; Department of Neurology, University of Essen, Germany.; The major problem in determining the role of HIV-1 infection in the pathogenesis of peripheral neuropathy is the difficulty in separating possible effects of confounding factors such as other infections, malnutrition, neurotoxic medication, drug abuse and antiretrovir
Concordance between polymerase chain reaction and antibody detection in the diagnosis of human immunodeficiency virus type 1 infection.: Eur J Clin Microbiol Infect Dis. 1995 Nov;14(11):1011-14. Unique Identifier : AIDSLINE MED/96246490; Romano L; Catucci M; De Milito A; Venturi G; Zazzi M; Almi P; Gonnelli A; Rubino M; Maestrini R; Valensin PE; Dipartimento di Biologia Molecolare, Universita di Siena, Italy.; A highly sensitive nested polymerase chain reaction (PCR) protocol was used to detect human immunodeficiency virus type 1 (HIV-1) DNA in peripheral blood mononuclear cells from 271 HIV-1-seropositive patients, 240 HIV-1-seronegative subjects at increased risk for HIV-1 infection, 51 serologically indeterminate individ
Influence of human immunodeficiency virus type 1 infection on the natural course of chronic parenterally acquired hepatitis C.: Eur J Clin Microbiol Infect Dis. 1995 Nov;14(11):949-53. Unique Identifier : AIDSLINE MED/96246479; Sanchez-Quijano A; Andreu J; Gavilan F; Luque F; Abad MA; Soto B; Munoz J; Aznar JM; Leal M; Lissen E; Department of Internal Medicine, Virgen del Rocio University; Hospital, Seville, Spain.; The aim of the present study was to investigate the possible role of human immunodeficiency virus (HIV) infection in the natural course of chronic hepatitis C. Seventy-six adult patients with chronic parenterally acquired hepatitis C virus (HCV) infection examined from 1989 to 1993 were enrolled; of these 32 (42.1%) w
Development of subtle neurological signs after systemic illness in HIV-infected individuals.: Eur Neurol. 1996;36(2):71-5. Unique Identifier : AIDSLINE MED/96233869; Lopez OL; Becker JT; Banks G; Giconi J; Sanchez J; Dorst SK; Department of Neurology, University of Pittsburgh School of; Medicine, Pa, USA.; Thirty human immunodeficiency virus (HIV) infected individuals entered a longitudinal study without signs of dysfunction of the central nervous system (CNS). Nine of these individuals developed a systemic illness between study visits, and 7 of these 9 patients (78%) had neurological signs at the next examination (e.g.
Emergence of cryptococcal disease: epidemiologic perspectives 100 years after its discovery.: Epidemiol Rev. 1995;17(2):303-20. Unique Identifier : AIDSLINE MED/96261321; Hajjeh RA; Brandt ME; Pinner RW; Emerging Bacterial and Mycotic Diseases Branch, Centers for; Disease Control and Prevention, Atlanta, GA 30333, USA.
Variation of intracellular distribution of mRNAs expressed from transfected cDNAs--a study by FISH.: Biochem Soc Trans. 1995 Nov;23(4):588S. Unique Identifier : AIDSLINE MED/96227277; Fu L; Suen CK; White KN; Division of Biochemistry and Molecular Biology, UMDS, Guy's; Hospital, London, U.K.
Nucleoside spiroxiranes as suicide inhibitors of the human immunodeficiency virus.: Biochem Soc Trans. 1995 Nov;23(4):619S. Unique Identifier : AIDSLINE MED/96227308; Bailey JM; Nelson KA; Department of Biochemistry and Molecular Biology, George; Washington University, School of Medicine and Health Sciences,; Washington, D.C., USA.
Refined solution structure of p17, the HIV matrix protein.: Biochem Soc Trans. 1995 Nov;23(4):725-9. Unique Identifier : AIDSLINE MED/96227117; Matthews S; Barlow P; Clark N; Kingsman S; Kingsman A; Campbell I; Department of Biochemistry, University of Oxford, U.K.
Reaching young adults through entertainment.: Popul Rep J. 1995 Oct;(41 Suppl |reaching|):4p.. Unique Identifier : AIDSLINE MED/96244100
pHIVTATA-CAT, a versatile vector to study transcriptional regulatory elements in mammalian cells.: Gene. 1996 Feb 12;168(2):173-6. Unique Identifier : AIDSLINE MED/96194892; Thiel G; Petersohn D; Schoch S; Institute for Genetics, University of Cologne, Germany.; thiel@genetik.uni-koeln.de; We have constructed a vector, pHIVTATA-CAT, that contains the Escherichia coli cat gene, encoding chloramphenicol acetyltransferase, under the control of a minimal promoter consisting of the HIV TATA box and the adenovirus major late promoter initiator element. Putative transcriptional elements can be inserted either
An evaluation of the antioxidant and antiviral action of extracts of rosemary and Provencal herbs.: Food Chem Toxicol. 1996 May;34(5):449-56. Unique Identifier : AIDSLINE MED/96243794; Aruoma OI; Spencer JP; Rossi R; Aeschbach R; Khan A; Mahmood N; Munoz A; Murcia A; Butler J; Halliwell B; Pharmacology Group, University of London King's College, UK.; Extracts of herbs and spices are increasingly of interest in the food industry because they retard oxidative degradation of lipids. There is also increasing interest in the antiviral activity of plant products. A liquid, deodorized rosemary extract and an oily extract of a mixture of Provencal herbs were tested for an
AIDS survival and progression in black Africans living in south London, 1986-1994.: Genitourin Med. 1996 Feb;72(1):12-6. Unique Identifier : AIDSLINE MED/96246549; Low N; Paine K; Clark R; Mahalingam M; Pozniak AL; Department of Genitourinary Medicine, King's College School of; Medicine & Dentistry, London.; OBJECTIVES: To describe the rate of progression to AIDS and survival following AIDS diagnosis in HIV-infected Africans living in London. To identify factors influencing progression and outcome of disease. DESIGN: Retrospectively constructed prevalent cohort. SETTING: Outpatient clinic population, London. SUBJECTS: HIV
Ups and downs--and ups in the antiviral therapy of HIV infection.: Genitourin Med. 1996 Feb;72(1):2-5. Unique Identifier : AIDSLINE MED/96246546; Weller IV; Williams I; Department of Sexually Transmitted Diseases, University College; London Medical School.
Reference ranges and sources of variability of CD4 counts in HIV-seronegative women and men.: Genitourin Med. 1996 Feb;72(1):27-31. Unique Identifier : AIDSLINE MED/96246552; Maini MK; Gilson RJ; Chavda N; Gill S; Fakoya A; Ross EJ; Phillips AN; Weller IV; Department of Genitourinary Medicine, Camden and Islington; Community Health Services NHS Trust, London, UK.; BACKGROUND: CD4 lymphocyte counts are used to monitor immune status in HIV disease. An understanding of the variability of CD4 counts which occurs in the absence of HIV infection is essential to their interpretation. The sources and degree of such variability have not been extensively studied. OBJECTIVES: To establish
Changes in sexual behaviour of patients attending an HIV testing centre: a prospective study 1988-1994.: Genitourin Med. 1996 Feb;72(1):37-42. Unique Identifier : AIDSLINE MED/96246554; Cribier B; Schmitt MP; Le Coz C; Grosshans E; Clinique Dermatologique, Hopitaux Universitaires, Strasbourg,; France.; OBJECTIVE: To evaluate the sexual behaviour changes in patients attending HIV testing during the period July 1988 to June 1994. DESIGN: In a prospective study, 6824 face-to-face interviews were carried out before the HIV test was performed. The frequency of condom use and the number of sexual partners during the 6 pre
Sexual health and use of condoms among local and international sex workers in Sydney.: Genitourin Med. 1996 Feb;72(1):47-51. Unique Identifier : AIDSLINE MED/96246556; O'Connor CC; Berry G; Rohrsheim R; Donovan B; Academic Unit of Sexual Health Medicine, University of Sydney,; Australia.; OBJECTIVES: To compare indicators of sexual health and predictors of condom use for commercial sex among local and international female sex workers first attending an STD clinic. SETTING: A public STD clinic in Sydney, Australia . SUBJECTS: All sex workers first attending between
Fatal haemorrhage following liver biopsy in patients with HIV infection.: Genitourin Med. 1996 Feb;72(1):62-4. Unique Identifier : AIDSLINE MED/96246560; Churchill DR; Mann D; Coker RJ; Miller RF; Glazer G; Goldin RD; Lucas SB; Weber JN; De Cock KM; Department of Genitourinary Medicine, Communicable Diseases, St; Mary's Hospital and Medical School, London.; A retrospective review of all 248 liver biopsies performed in patients with HIV infection at two referral centres in London over a 12 year period revealed five cases of major bleeding following biopsy, with four deaths. The risk of major bleeding was 2.0%, and mortality was 1.6% following liver biopsy. The risk of ble
Male duct ectasia associated with HIV infection.: Genitourin Med. 1996 Feb;72(1):65-6. Unique Identifier : AIDSLINE MED/96246561; Downs AM; Fisher M; Tomlinson D; Tanner A; Department GenitoUrinary Medicine, St Marys Hospital, London, UK.; The incidence of male duct ectasia (periductal mastitis) is extremely rare, only eight cases having been reported. The underlying cause (as in females) is uncertain. Two cases in HIV positive males of recurrent unilateral nipple lesions are reported with histology consistent with duct ectasia. At presentation neither
Gonorrhoea in HIV seropositive homosexual men attending an East London genitourinary medicine clinic [letter]: Genitourin Med. 1996 Feb;72(1):74. Unique Identifier : AIDSLINE MED/96246568; Lewis DA; Forster GE; Goh B
Community-based respiratory viral infections in HIV positive patients with lower respiratory tract disease: a prospective bronchoscopic study.: Genitourin Med. 1996 Feb;72(1):9-11. Unique Identifier : AIDSLINE MED/96246548; Miller RF; Loveday C; Holton J; Sharvell Y; Patel G; Brink NS; Academic Department of Genitourinary Medicine, University College; London Medical School.; OBJECTIVES: To evaluate the contribution of community-based respiratory virus infections to lower respiratory tract disease in HIV-1 infected individuals. DESIGN: Prospective clinical cohort study. SETTING: Specialist in-patient unit for HIV and AIDS, University College London Hospitals, London. SUBJECTS: 44 consecuti
Pharmacokinetics of orally administered zidovudine in HIV-infected children and adults.: Infection. 1995 Nov-Dec;23(6):344-8. Unique Identifier : AIDSLINE MED/96263607; Wintergerst U; Rolinski B; Vocks-Hauck M; Wahn V; Debatin KM; Notheis G; Grosch-Worner I; Goebel FD; Roscher AA; Belohradsky BH; Universitats-Kinderklinik Munchen, Germany.; The pharmacokinetics of oral zidovudine in HIV-infected children and adults are reported. Fourty-six patients were investigated. For data analysis three groups of similar size were formed: young children 4 months-4 years, n = 15 (group 1), older children up to 13 years, n = 16 (group 2) and young adults, n = 15 (group
Clinical and microscopical features of small-intestinal microsporidiosis in patients with AIDS.: Infection. 1995 Nov-Dec;23(6):362-8. Unique Identifier : AIDSLINE MED/96263610; Caramello P; Mazzucco G; Romeo M; Ullio A; DeRosa G; Lucchini A; Forno B; Brancale T; Macor A; Preziosi C; et al; Institute of Infectious Diseases, University of Turin, Italy.; Intestinal microsporidiosis by Enterocytozoon bieneusi is an increasingly recognized infection in AIDS patients. We report eight cases of microsporidiosis. All patients were severely immunodepressed. Clinical features were highly variable. Patients were followed up for
First case of HIV-1 subtype 0 infection in Germany.: Infection. 1995 Nov-Dec;23(6):369-70. Unique Identifier : AIDSLINE MED/96263611; Hampl H; Sawitzky D; Stoffler-Meilicke M; Groh A; Schmitt M; Eberle J; Gurtler L; Institut fur Klinische und Experimentelle Virologie, Freie; Universitat Berlin, Germany.
[HIV infections in Switzerland]: Internist (Berl). 1996 Apr;37(4):419-21. Unique Identifier : AIDSLINE MED/96230700; Schneider RE; Institut Froideville, Posieux.
Exogenous and endogenous opioids as biological response modifiers.: Immunopharmacology. 1995 Nov;31(1):59-71. Unique Identifier : AIDSLINE MED/96245822; Carr DJJ; Serou M; Department of Microbiology, Stanley S. Scott Cancer Center, New; Orleans, LA 70112-1393, USA. dcarr@pop3.1sumc.edu; Narcotic opioid compounds are among the most widely prescribed drug interventions for individuals suffering pain. Among the unwarranted side effects of respiratory depression, constipation, and physical dependence are the immunosuppressive qualities, particularly those which affect cell-mediated immunity. The immunosu
Stimulation of human immunodeficiency virus type 1 infected cells with superoxide enhances the chemotactic motile response of CD4+ human T cells: implication for virus transmission by cell-to-cell interaction.: Immunopharmacology. 1995 Nov;31(1):73-84. Unique Identifier : AIDSLINE MED/96245823; Okada Y; Kameoka M; Kimura T; Azuma I; Ikuta K; Institute of Immunological Science, Hokkaido University, Sapporo,; Japan.; We previously showed that superoxide (O2-) significantly enhanced human immunodeficiency virus type 1 (HIV-1)-induced syncytia formation in co-cultured infected and uninfected human T cells. In this study, we describe a novel chemotactic response of uninfected CD4+ T cells by stimulating infected T cells with O2-. Syn
Pentoxifylline therapy in HIV seropositive subjects with elevated TNF.: Immunopharmacology. 1995 Nov;31(1):85-91. Unique Identifier : AIDSLINE MED/96245824; Kruse A; Rieneck K; Kappel M; Orholm M; Bruunsgaard H; Ullum H; Skinhoj P; Pedersen BK; Department of Infectious Diseases, Copenhagen N, Denmark.; Tumor necrosis factor-alpha (TNF-alpha) is thought to induce cachexia in subjects infected with human immunodeficiency virus (HIV), and it has been suggested that HIV-seropositive patients would benefit from treatment with pentoxifylline, a known suppressor of TNF-alpha production. The purpose of the present study was
Expression of TIA-1 and TIA-2 in T cell malignancies and T cell lymphocytosis.: J Clin Pathol. 1996 Feb;49(2):154-8. Unique Identifier : AIDSLINE MED/96264437; Matutes E; Coelho E; Aguado MJ; Morilla R; Crawford A; Owusu-Ankomah K; Catovsky D; Academic Department of Haematology and Cytogenetics, Royal; Marsden Hospital, London.; OBJECTIVE: To investigate the reactivity with TIA-1 and TIA-2, two monoclonal antibodies that recognise, respectively, granular structures in T lymphocytes and the T cell receptor chain in cells from a variety of T cell disorders. METHODS: Cytoplasmic staining with TIA-1 and TIA-2 was carried out by the immunoalkaline
Herpes virus-like sequences are specifically found in Kaposi sarcoma lesions.: J Clin Pathol. 1996 Apr;49(4):306-8. Unique Identifier : AIDSLINE MED/96263265; O'Neill E; Henson TH; Ghorbani AJ; Land MA; Webber BL; Garcia JV; Department of Virology/Molecular Biology, St Jude Children's; Research Hospital, Memphis, TN 38105, USA.; AIM: To detect the prevalence of herpes virus-like DNA sequences in AIDS associated Kaposi sarcoma (KSHV) lesions and normal tissue. METHODS: KSHV detection was performed by polymerase chain reaction (PCR) using four different sets of primers. PCR products were cloned, sequenced, and analysed. RESULTS: All of four bio
Bacillus piliformis infection (Tyzzer's disease) in a patient infected with HIV-1: confirmation with 16S ribosomal RNA sequence analysis.: J Am Acad Dermatol. 1996 Feb;34(2 Pt 2):343-8. Unique Identifier : AIDSLINE MED/96225821; Smith KJ; Skelton HG; Hilyard EJ; Hadfield T; Moeller RS; Tuur S; Decker C; Wagner KF; Angritt P; AIDS Registry, Armed Forces Institute of Pathology, Washington,; D.C., USA.; Bacillus piliformis is a long, rod-shaped bacterium that has never been grown in cell-free medium and whose taxonomic classification is uncertain. B. piliformis is the causative agent of Tyzzer s disease, which is frequently reported in laboratory, wild, and domesticated animals. The spectrum and severity of this dise
CD7-positive Sezary syndrome with a Th1 cytokine profile.: J Am Acad Dermatol. 1996 Feb;34(2 Pt 2):368-74. Unique Identifier : AIDSLINE MED/96225827; Yagi H; Tokura Y; Furukawa F; Takigawa M; Department of Dermatology, Hamamatsu University School of; Medicine, Japan.; Sezary syndrome is a leukemic variant of cutaneous T-cell lymphoma characterized by the appearance of numerous CD4+ cells with cerebriform nuclei in the peripheral blood. Recent observations have suggested that Sezary cells lack CD7 molecules on their surface and are analogous to murine Th2 cells. It remains unclear,
Vaccines: new approaches and concepts.: J Allergy Clin Immunol. 1996 Apr;97(4):896-906. Unique Identifier : AIDSLINE MED/96194240; Dickler HB; Collier E; Clinical Immunology Branch, National Institute of Allergy and; Infectious Diseases, Bethesda, MD 20892, USA.
CD4 T-lymphocyte activation is associated with peak expiratory flow variability in childhood asthma.: J Allergy Clin Immunol. 1996 Apr;97(4):955-62. Unique Identifier : AIDSLINE MED/96194246; Doi S; Murayama N; Inoue T; Takamatsu I; Kameda M; Omoto Y; Toyoshima K; Department of Pediatric Allergy, Osaka Prefectural Habikino; Hospital, Japan.; BACKGROUND: Asthma has been recognized as a chronic inflammatory disorder of the airway. We have investigated the relationships among the activation markers on lymphocytes, eosinophils, their serum products in the peripheral blood, and the variability of airway obstruction in childhood asthma. METHODS: Twenty-two pati
Weight gain and increased concentrations of receptor proteins for tumor necrosis factor after patients with symptomatic HIV infection received fortified nutrition support.: J Am Diet Assoc. 1996 Jun;96(6):565-9. Unique Identifier : AIDSLINE MED/96248129; Suttmann U; Ockenga J; Schneider H; Selberg O; Schlesinger A; Gallati H; Wolfram G; Deicher H; Muller MJ; Zentrum Innere Medizin und Dermatologie, Abteilung Klinische; Immunologie, Lehrte, Germany.; OBJECTIVE: To determine whether certain nutrients and dietary factors act as modulators of the immune system and improve the nutritional status of immunocompromised patients. DESIGN: Controlled, double-blind, crossover phase trials of the effects of a fortified formula in patients infected with the human immunodeficie
AIDS in the elderly: New York City vital statistics.: J Emerg Med. 1996 Jan-Feb;14(1):19-23. Unique Identifier : AIDSLINE MED/96244975; Gaeta TJ; LaPolla C; Melendez E; Department of Emergency Medicine, St. Barnabas Hospital, Bronx,; New York 10457, USA.; The HIV infection primarily affects young adults, but older adults are also susceptible. The number of AIDS cases among persons aged 50 or greater is growing and is of major concern. As our awareness of the prevalence of HIV-related illnesses presenting to the emergency department improves in the younger population, w
Genetic diversity at the internal transcribed spacer regions of the rRNA operon among isolates of Pneumocystis carinii from AIDS patients with recurrent pneumonia.: J Infect Dis. 1996 Jul;174(1):141-56. Unique Identifier : AIDSLINE GENBANK/M96382; Tsolaki AG; Miller RF; Underwood AP; Banerji S; Wakefield AE; Department of Paediatrics, John Radcliffe Hospital, Oxford,; United Kingdom.; The opportunistic fungal pathogen Pneumocystis carinii sp. f. hominis is a frequent cause of pneumonia in the immunocompromised host. Analysis of genetic variation among isolates of P. carinii sp. f. hominis from 12 human immunodeficiency virus (HIV)-infected persons with single and multiple episodes of P. carinii pne
Lamivudine in children with human immunodeficiency virus infection: a phase I/II study. The National Cancer Institute Pediatric Branch-Human Immunodeficiency Virus Working Group.: J Infect Dis. 1996 Jul;174(1):16-25. Unique Identifier : AIDSLINE MED/96261989; Lewis LL; Venzon D; Church J; Farley M; Wheeler S; Keller A; Rubin M; Yuen G; Mueller B; Sloas M; Wood L; Balis F; Shearer GM; Brouwers P; Goldsmith J; Pizzo PA; Pediatric Branch, National Cancer Institute, National Institutes; of Health, Bethesda, Maryland, USA.; The safety, tolerability, pharmacokinetic profile, and preliminary activity of lamivudine (2 -deoxy-3 -thiacytidine), a novel cytidine nucleoside analogue with antiretroviral activity, in human immunodeficiency virus (HIV)-infected children beyond the neonatal period were studied. Ninety children received dosages of 1
Cytomegalovirus glycoprotein B groups associated with retinitis in AIDS.: J Infect Dis. 1996 Jul;174(1):184-7. Unique Identifier : AIDSLINE MED/96262011; Shepp DH; Match ME; Ashraf AB; Lipson SM; Millan C; Pergolizzi R; Department of Medicine, North Shore University Hospital,; Manhasset, NY 11030, USA.; To determine if cytomegalovirus ( CMV ) retinitis occurs more frequently in patients infected with certain strains CMV isolates from the blood of 44 patients with advanced human immunodeficiency virus disease were grouped by th
Low plasma concentrations achieved with conventional schedules of administration of ganciclovir in patients with AIDS.: J Infect Dis. 1996 Jul;174(1):188-90. Unique Identifier : AIDSLINE MED/96262012; Piketty C; Bardin C; Gilquin J; Mahe V; Kazatchkine MD; Chast F; Unite d'Immunologie Clinique, Hopital Broussais, Paris, France.; Plasma concentration of ganciclovir was studied prospectively in 15 AIDS patients treated for acute cytomegalovirus ( CMV ) retinitis. Ganciclovir was administered at a mean dose of 10.3 +/- 0.6 mg/kg/day. The mean trough plasm
Variation in plasma RNA levels, CD4 cell counts, and p24 antigen levels in clinically stable men with human immunodeficiency virus infection.: J Infect Dis. 1996 Jul;174(1):191-4. Unique Identifier : AIDSLINE MED/96262013; Raboud JM; Montaner JS; Conway B; Haley L; Sherlock C; O'Shaughnessy MV; Schechter MT; Department of Health Care and Epidemiology, University of British; Columbia, Canada.; Short-term variability in CD4 cell counts, plasma RNA levels, and p24 antigenemia was measured in clinically stable men with human immunodeficiency virus infection. Blood samples were obtained three times in each of 2 weeks 4 weeks apart. Differences between duplicate assays were considered to be due to technical fact
Primary infection with zidovudine-resistant human immunodeficiency virus type 1 does not adversely affect outcome at 1 year. Sydney Primary HIV Infection Study Group.: J Infect Dis. 1996 Jul;174(1):195-8. Unique Identifier : AIDSLINE MED/96262014; Imrie A; Carr A; Duncombe C; Finlayson R; Vizzard J; Law M; Kaldor J; Penny R; Cooper DA; Centre for Immunology, St Vincent's Hospital, Sydney, Australia.; Human immunodeficiency virus type 1 (HIV-1) variants with reduced in vitro sensitivity to zidovudine, conferred by specific mutations in the viral reverse transcriptase, emerge during prolonged therapy. Late-stage disease and declining CD4 cell count are associated with more rapid emergence of these resistant variants
Pseudouridine and 1-ribosylpyridin-4-one-3-carboxamide (PCNR) serum concentrations in human immunodeficiency virus type 1-infected patients are independent predictors for AIDS progression.: J Infect Dis. 1996 Jul;174(1):199-203. Unique Identifier : AIDSLINE MED/96262015; Intrieri M; Calcagno G; Oriani G; Pane F; Zarrilli F; Cataldo PT; Foggia M; Piazza M; Salvatore F; Sacchetti L; Dipartimento di Biochimica e Biotecnologie Mediche, Universita; degli Studi di Napoli, Federico II, Italy.; A prospective study was conducted with 161 human immunodeficiency virus (HIV)-positive patients to investigate the prognostic role of 10 serum-modified nucleosides with regard to some of the most widely used parameters of AIDS progression. Serum concentrations of pseudouridine (> 3.77 nmol/mL) predicted progression to
Treatment of human immunodeficiency virus infection with hydroxyurea: virologic and clinical evaluation.: J Infect Dis. 1996 Jul;174(1):204-9. Unique Identifier : AIDSLINE MED/96262016; Giacca M; Zanussi S; Comar M; Simonelli C; Vaccher E; de Paoli P; Tirelli U; International Centre for Genetic Engineering and Biotechnology,; Trieste, Italy.; To assess the efficacy of the therapeutic use of inhibitors of ribonucleotide reductase for the treatment of human immunodeficiency virus (HIV) type 1 infection, 7 consecutive patients were enrolled in a clinical trial involving monotherapy with hydroxyurea for 8-19 weeks. During therapy, patients were evaluated for c
Lysis of human immunodeficiency virus type 1 antigen-expressing cells by CD4 and CD8 T cells ex vivo.: J Infect Dis. 1996 Jul;174(1):209-13. Unique Identifier : AIDSLINE MED/96262017; Heinkelein M; Euler-Konig I; Klinker H; Ruckle-Lanz H; Jassoy C; Department of Internal Medicine, and Medical Policlinic,; University of Wurzburg, Germany.; The aim of this study was to investigate the extent of lysis mediated by cytotoxic T lymphocytes (CTL) directed against human immunodeficiency virus (HIV) type 1 gag protein and envelope glycoprotein in peripheral blood mononuclear cells (PBMC) from HIV-1-infected subjects and to compare it with nonspecific envelope g
In vitro inhibition of the replication of human immunodeficiency virus type 1 by beta-mercaptoethylamine (cysteamine).: J Infect Dis. 1996 Jul;174(1):214-8. Unique Identifier : AIDSLINE MED/96262018; Bergamini A; Ventura L; Mancino G; Capozzi M; Placido R; Salanitro A; Cappannoli L; Faggioli E; Stoler A; Rocchi G; Department of Public Health and Cellular Biology, University of; Rome, Tor Vergata, Italy.; This study investigates the effects of cysteamine alone and in association with zidovudine or didanosine on the replication of human immunodeficiency virus type 1 (HIV-1). More than 90% viral inhibition was obtained by 200 microM cysteamine in lymphocytes and 100 microM cysteamine in macrophages against 4 primary isol
Diagnosis of neurosyphilis in patients infected with human immunodeficiency virus type 1.: J Infect Dis. 1996 Jul;174(1):219-21. Unique Identifier : AIDSLINE MED/96262019; Marra CM; Gary DW; Kuypers J; Jacobson MA; Department of Neurology, University of Washington, Seattle, USA.; Establishing the diagnosis of neurosyphilis may be particularly difficult in human immunodeficiency virus type 1 (HIV)-infected persons. Polymerase chain reaction (PCR) was used to detect Treponema pallidum DNA in cerebrospinal fluid (CSF) from 81 HIV-infected patients. On the basis of reactive serum and CSF-VDRL test
Iron overload as a mechanism for the lowered survival in AIDS patients receiving dapsone-iron protoxalate for secondary prophylaxis of Pneumocystis carinii pneumonia [letter; comment]: J Infect Dis. 1996 Jul;174(1):241-2. Unique Identifier : AIDSLINE MED/96262026; Weinberg GA
The changing epidemiology of pneumococcal bacteremia in human immunodeficiency virus infection [letter]: J Infect Dis. 1996 Jul;174(1):242-4. Unique Identifier : AIDSLINE MED/96262027; Earhart KC; Wallace MR
False-negative polymerase chain reaction-based diagnosis of human immunodeficiency virus (HIV) type 1 in children infected with HIV strains of African origin [letter; comment]: J Infect Dis. 1996 Jul;174(1):244-5. Unique Identifier : AIDSLINE MED/96262028; Haas J; Geiss M; Bohler T
No evidence for a role of enteroadherent Escherichia coli in diarrhea in human immunodeficiency virus-infected patients [letter]: J Infect Dis. 1996 Jul;174(1):246. Unique Identifier : AIDSLINE MED/96262029; Schultsz C; Snijders F; Dankert J
Factors influencing human immunodeficiency virus type 1 transmission by blood transfusion. Transfusion Safety Study Group.: J Infect Dis. 1996 Jul;174(1):26-33. Unique Identifier : AIDSLINE MED/96261990; Busch MP; Operskalski EA; Mosley JW; Lee TH; Henrard D; Herman S; Sachs DH; Harris M; Huang W; Stram DO; Irwin Memorial Blood Centers, University of California, San; Francisco, USA.; One hundred thirty-two recipients of blood components that retrospectively tested positive for antibody to human immunodeficiency virus type 1 (anti-HIV-1) were identified. Fourteen (11%) remained seronegative throughout follow-up. Donor and recipient characteristics that could have influenced transmission were examin
Human immunodeficiency virus type 1 (HIV-1)--and Epstein-Barr virus--specific cytotoxic T lymphocyte precursors exhibit different kinetics in HIV-1--infected persons.: J Infect Dis. 1996 Jul;174(1):34-45. Unique Identifier : AIDSLINE MED/96261991; Geretti AM; Dings ME; van Els CA; van Baalen CA; Wijnholds FJ; Borleffs JC; Osterhaus AD; Institute of Virology, Erasmus University Rotterdam, Netherlands.; The frequencies of human immunodeficiency virus type 1 (HIV-1) Gag- and Epstein-Barr virus (EBV)-specific cytotoxic T lymphocyte precursors (CTLp) were studied longitudinally in peripheral blood mononuclear cells from 9 HIV-1-infected persons. By antigen-specific stimulation, HIV-1 Gag-specific CTLp were detected in v
Molecular analysis of decreased interleukin-12 production in persons infected with human immunodeficiency virus.: J Infect Dis. 1996 Jul;174(1):46-53. Unique Identifier : AIDSLINE MED/96261992; Chougnet C; Wynn TA; Clerici M; Landay AL; Kessler HA; Rusnak J; Melcher GP; Sher A; Shearer GM; Experimental Immunology Branch, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892-1360,; USA.; Human immunodeficiency virus (HIV) disease is associated with loss of type 1 responses, including interleukin (IL)-12 production. The dramatic drop in p70 production seen at early stages of disease was found not to be associated with a similarly decreased p40 mRNA expression. p35 mRNA expression was more extensively r
Engagement of adhesion molecules (CD18, CD11a, CD45, CD44, and CD58) enhances human immunodeficiency virus type 1 replication in monocytic cells through a tumor necrosis factor-modulated pathway.: J Infect Dis. 1996 Jul;174(1):54-62. Unique Identifier : AIDSLINE MED/96261993; Shattock RJ; Rizzardi GP; Hayes P; Griffin GE; Division of Infectious Diseases, St. George's Hospital Medical; School, London, United Kingdom.; Engagement of monocytic cell membrane proteins was shown to enhance human immunodeficiency virus type 1 (HIV-1) replication in monocytic cells. Cross-linking of CD18, CD11a, or CD45 by immobilized antibodies produced up to an 11-fold enhancement of HIV-1 release in the OM10.1 monocytic cell line in a tumor necrosis fa
Inhibition of immunoreactive tumor necrosis factor-alpha by a chimeric antibody in patients infected with human immunodeficiency virus type 1.: J Infect Dis. 1996 Jul;174(1):63-8. Unique Identifier : AIDSLINE MED/96261994; Walker RE; Spooner KM; Kelly G; McCloskey RV; Woody JN; Falloon J; Baseler M; Piscitelli SC; Davey RT Jr; Polis MA; Kovacs JA; Masur H; Lane HC; National Institute of Allergy and Infectious Diseases, Critical; Care Medicine Department, National Institutes of Health,; Bethesda, MD 20892, USA.; Tumor necrosis factor-alpha (TNF-alpha), a proinflammatory cytokine known to stimulate human immunodeficiency virus type 1 (HIV-1) replication, has been implicated in the pathogenesis of HIV-1 infection. Inhibition of TNF-alpha by a chimeric humanized monoclonal antibody, cA2, was investigated in 6 HIV-1-infected pati
Adenosine deaminase isoenzymes and pleural tuberculosis [editorial; comment]: J Lab Clin Med. 1996 Apr;127(4):326-7. Unique Identifier : AIDSLINE MED/96202697; Antony VB
The lectin jacalin triggers CD4-mediated lymphocyte signaling by binding CD4 through a protein-protein interaction.: J Leukoc Biol. 1996 May;59(5):691-6. Unique Identifier : AIDSLINE MED/96239300; Lafont V; Dornand J; Covassin L; Liautard JP; Favero J; Institut National de la Sante et de la Recherche Medicale,; Department de Biologie Sante, Universite de Montpellier II,; France.; The lectin jacalin specifically stimulates lymphocytes expressing the CD4 antigen. Recent studies have also demonstrated that this lectin interacts with CD4, inhibits in vitro HIV infection, and triggers cell signaling directly via CD4. Jacalin as a lectin was suggested to trigger CD4-mediated cell signaling by intera
The relationship of HIV status, type of coagulation disorder, and school absenteeism to cognition, educational performance, mood, and behavior of boys with hemophilia.: J Genet Psychol. 1996 Jun;157(2):137-51. Unique Identifier : AIDSLINE MED/96241891; Mayes SD; Handford HA; Schaefer JH; Scogno CA; Neagley SR; Michael-Good L; Pelco LE; Department of Psychiatry, College of Medicine, Pennsylvania State; University, USA.; Psychological and educational data were analyzed for all school-aged males with hemophilia at the Hemophilia Center of Central Pennsylvania (N = 66). Mean IQ (113.5) was higher than normal, and 2.4 times as many boys with hemophilia were enrolled in gifted programming than is the state average for boys. However, there
Basic research plays a key role in new patient treatments [news]: J Natl Cancer Inst. 1996 Jul 3;88(13):869. Unique Identifier : AIDSLINE MED/96264987; Law C
Serum HIV-1 RNA levels and time to development of AIDS in the Multicenter Hemophilia Cohort Study.: JAMA. 1996 Jul 10;276(2):105-10. Unique Identifier : AIDSLINE MED/96272949; O'Brien TR; Blattner WA; Waters D; Eyster E; Hilgartner MW; Cohen AR; Luban N; Hatzakis A; Aledort LM; Rosenberg PS; Miley WJ; Kroner BL; Goedert JJ; Viral Epidemiology Branch, National Cancer Institute, Rockville,; MD 20852, USA.; OBJECTIVE--To determine if the long-term incidence of the acquired immunodeficiency syndrome (AIDS) is related to human immunodeficiency virus type 1 (HIV-1) RNA levels measured early in HIV-1 infection. DESIGN--Epidemiologic cohort study. SETTING--Five hemophilia treatment centers in the
Safety and efficacy of lamivudine-zidovudine combination therapy in zidovudine-experienced patients. A randomized controlled comparison with zidovudine monotherapy. Lamivudine European HIV Working Group.: JAMA. 1996 Jul 10;276(2):111-7. Unique Identifier : AIDSLINE MED/96272950; Staszewski S; Loveday C; Picazo JJ; Dellarnonica P; Skinhoj P; Johnson MA; Danner SA; Harrigan PR; Hill AM; Verity L; McDade H; Klinikum der Johann Wolfgang Goethe Universitat, Frankturt,; Germany.; OBJECTIVE--To compare the safety and efficacy of 2 doses of lamivudine given in combination with zidovudine with continued zidovudine monotherapy. DESIGN--Double-blind, randomized, multicenter, comparative trial of 223 patients treated for 24 weeks. SETTING--Patients from 32 hospitals in Europe were enrolled throughou
Safety and efficacy of lamivudine-zidovudine combination therapy in antiretroviral-naive patients. A randomized controlled comparison with zidovudine monotherapy. Lamivudine European HIV Working Group.: JAMA. 1996 Jul 10;276(2):118-25. Unique Identifier : AIDSLINE MED/96272951; Katlama C; Ingrand D; Loveday C; Clumeck N; Mallolas J; Staszewski S; Johnson M; Hill AM; Pearce G; McDade H; Hospitalier Pitie Salpetriere, Paris, France.; OBJECTIVE--To compare safety and efficacy of lamivudine-zidovudine combination therapy with zidovudine monotherapy in treating human immunodeficiency virus type 1 (HIV-1)-infected, antiretroviral therapy-naive patients. DESIGN--Double-blind, randomized, multicenter, co
Prevalence of HIV infection in the United States, 1984 to 1992.: JAMA. 1996 Jul 10;276(2):126-31. Unique Identifier : AIDSLINE MED/96272952; Karon JM; Rosenberg PS; McQuillan G; Khare M; Gwinn M; Petersen LR; Division of HIV/AIDS Prevention Centers for Disease Control and; Prevention, Atlanta, GA 30333, USA.; OBJECTIVE--To estimate the number of persons infected with the human immunodeficiency virus (HIV) living in the United States and the change in HIV infection prevalence since 1984. DESIGN--We estimated HIV prevalence from 3 data sources. We estimated past HIV infection rates from a sta
Economic impact of treatment of HIV-positive pregnant women and their newborns with zidovudine. Implications for HIV screening.: JAMA. 1996 Jul 10;276(2):132-8. Unique Identifier : AIDSLINE MED/96272953; Mauskopf JA; Paul JE; Wichman DS; White AD; Tilson HH; Glaxo Welcome Inc., Research Triangle Park, NC 27709, USA.; OBJECTIVES--To estimate the economic impact of (1) treating pregnant women who are human immunodeficiency virus (HIV)-positive with zidovudine and (2) voluntary screening programs for pregnant women for HIV infection and offering treatment with zidovudine to those found to be HIV-positive. MAIN OUTCOME MEASURES--Numbe
Cost-effectiveness of short-course zidovudine to prevent perinatal HIV type 1 infection in a sub-Saharan African Developing country setting.: JAMA. 1996 Jul 10;276(2):139-45. Unique Identifier : AIDSLINE MED/96272954; Mansergh G; Haddix AC; Steketee RW; Nieburg PI; Hu DJ; Simonds RJ; Rogers M; Epidemiology Branch, NCHSTP, MSE-45, Centers for Disease Control; and Prevention, Atlanta, GA 30333, USA.; OBJECTIVE--To evaluate the cost-effectiveness of a short-course zidovudine program to prevent perinatal transmission of human immunodeficiency virus (HIV) type 1 in sub-Saharan African country settings. DESIGN AND SETTING--Several clinical trials of short-course zidovudine during pregnancy for prevention of perinatal
Antiretroviral therapy for HIV infection in 1996. Recommendations of an international panel. International AIDS Society-USA.: JAMA. 1996 Jul 10;276(2):146-54. Unique Identifier : AIDSLINE MED/96272955; Carpenter CC; Fischl MA; Hammer SM; Hirsch MS; Jacobsen DM; Katzenstein DA; Montaner JS; Richman DD; Saag MS; Schooley RT; Thompson MA; Vella S; Yeni PG; Volberding PA; Brown University School of Medicine, Providence, RI, USA.; OBJECTIVE--To provide clinical recommendations for antiretroviral therapy for human immunodeficiency virus (HIV) disease with currently (mid 1996) available drugs. When to start therapy, what to start with, when to change, and what to change to were addressed. PARTICIPANTS--A 13-member panel representing international
AIDS in 1996. Much accomplished, much to do [editorial]: JAMA. 1996 Jul 10;276(2):155-6. Unique Identifier : AIDSLINE MED/96272956; Fauci AS
Importance of surrogate markers in evaluation of antiviral therapy for HIV infection.: JAMA. 1996 Jul 10;276(2):159-60. Unique Identifier : AIDSLINE MED/96272957; Deyton L; HIV Research Branch, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Surrogate markers in AIDS research. Is there truth in numbers?: JAMA. 1996 Jul 10;276(2):161-2. Unique Identifier : AIDSLINE MED/96272958; Levy JA; Cancer Research Institute, University of California, San; Francisco, School of Medicine, USA.
Issue dedicated to HIV/AIDS research.: JAMA. 1996 Jul 10;276(2):85-162. Unique Identifier : AIDSLINE MED/96294677
HIV guide for primary care physicians stresses patient-centered prevention [news]: JAMA. 1996 Jul 10;276(2):85-6. Unique Identifier : AIDSLINE MED/96272931; Voelker R
Penicillium marneffei part of Southeast Asian AIDS [news]: JAMA. 1996 Jul 10;276(2):86-7. Unique Identifier : AIDSLINE MED/96272932; Phillips P
From the Centers for Disease Control and Prevention. Update: provisional public health service recommendations for chemoprophylaxis after occupational exposure to HIV.: JAMA. 1996 Jul 10;276(2):90-2. Unique Identifier : AIDSLINE MED/96272935
The changing face of AIDS in Argentina.: JAMA. 1996 Jul 10;276(2):94-6. Unique Identifier : AIDSLINE MED/96272937; Betts CD; Astarloa L; Bloch C; Zacarias F; Chelala C; National Program Against Human Retrovirus and AIDS, Ministry of; Health and Social Action of Argentina, Buenos Aires.
A piece of my mind. Shadow bands.: JAMA. 1996 Jul 10;276(2):98. Unique Identifier : AIDSLINE MED/96272938; Lyons SF
Incidence of HIV infection in a New York City methadone maintenance treatment program [letter]: JAMA. 1996 Jul 10;276(2):99. Unique Identifier : AIDSLINE MED/96272939; Orr MF; Glebatis D; Friedmann P; des Jarlais DC; Prevots DR
Transmission of HIV-1 subtype E in the united states [letter]: JAMA. 1996 Jul 10;276(2):99-100. Unique Identifier : AIDSLINE MED/96272940; Artenstein AW; Ohl CA; VanCott TC; Hegerich PA; Mascola JR
HIV counseling and testing of pregnant women [letter]: JAMA. 1996 Jul 24-31;276(4):283-4. Unique Identifier : AIDSLINE MED/96286138; Phillips KA; Bleecker T; Morrison KR; Sonnad SS
[The role of some cellular components of bacterial parasites in determining the incidence of tuberculosis: studies on mycobacterial antigens, with special reference to mycobacterial immunoreactive ribosomal and secreted proteins]: Kekkaku. 1995 Nov;70(11):639-44. Unique Identifier : AIDSLINE MED/96111766; Yamada T; Ohara N; Matsumoto S; Matsuo T; Kitaura H; Yukitake H; Wada N; Nishiyama T; Naito M; Kinomoto M; et al; Nagasaki University, School of Dentistry, Japan.; Tuberculosis remains as major disease, affecting more than 20 million people. The elimination of the disease with vaccination, rapid diagnosis, and and efficient therapy is an important objective of our study. To realize the objective, the characterization of antigens is essential. We have chosen two kinds of antigens
[The mode of infection of tuberculosis--analysis using molecular epidemiologic methods]: Kekkaku. 1995 Nov;70(11):645-50. Unique Identifier : AIDSLINE MED/96111767; Abe C; Research Institute of Tuberculosis, Japan Anti-Tuberculosis; Association Matsuyama 3-1-24, Tokyo, Japan.; In the 1950 s, evidence showed that INH-resistant Mycobacterium tuberculosis organisms were attenuated in both virulence and pathogenicity in animals, and it was postulated that these bacilli might also be attenuated in their virulence to humans. Subsequent studies, however, indicated that all INH-resistant strains sh
[Clinical comparison of pulmonary tuberculosis with pulmonary M. avium complex disease]: Kekkaku. 1995 Nov;70(11):659-63. Unique Identifier : AIDSLINE MED/96111769; Suzuki K; Chest Disease Research Institute, Kyoto University, Japan.; At first, we reviewed radiographic findings of primary pulmonary tuberculosis, secondary pulmonary tuberculosis, pulmonary M. avium complex (MAC) disease without predisposing conditions, and pulmonary tuberculosis in AIDS patient. Infiltrates in lower field, mediastinal lymphadenopathy, and pleural effusion were the c
SF-20 score and item distributions in a human immunodeficiency virus-seropositive sample.: Med Care. 1996 Jun;34(6):562-9. Unique Identifier : AIDSLINE MED/96258356; Holmes W; Bix B; Shea J; Division of General Internal Medicine, Center for Clinical; Epidemiology and Biostatistics, University of Pennsylvania School; of Medicine, Philadelphia 19104-6021, USA.; The question of whether the full range of possible health states is measured by the Medical Outcomes Study (MOS) 20-Item Short-Form Health Survey (SF-20) in human immunodeficiency virus (HIV)-seropositive individuals is examined in this article. Ninety-five HIV-seropositive men (37 with asymptomatic infection, 58 with
Clinical predictors of functioning in persons with acquired immunodeficiency syndrome.: Med Care. 1996 Jun;34(6):610-23. Unique Identifier : AIDSLINE MED/96258360; Wilson IB; Cleary PD; Department of Medicine, New England Medical Center Hospitals,; Boston, MA, USA.; To help clinicians better assess and treat functional disabilities in persons with acquired immunodeficiency syndrome (AIDS), the authors estimate empirical relations among biologic and physiologic variables, symptoms, and physical functioning in persons with AIDS. The sample of 305 persons with AIDS for this cross-se
[Human gene therapy: trends and current problems]: Med Clin (Barc). 1996 Mar 30;106(12):469-76. Unique Identifier : AIDSLINE MED/96243280; Lazo PA; Unidad de Genetica Molecular (CSIC), Centro Nacional de; Biologia Celular y Retrovirus, Instituto de Salud Carlos III,; Majadahonda, Madrid.
[Disseminated Kaposi's sarcoma with hepatosplenic involvement in AIDS]: Med Clin (Barc). 1996 Apr 27;106(16):622-3. Unique Identifier : AIDSLINE MED/96243329; Gonzalez-Lopez A; Fernandez-Martin JI; Gordillo I; Dronda F; Unidad de Enfermedades Infecciosas-Microbiologia, Hospital; General Penitenciario, Madrid.; Kaposi sarcoma (KS) is the most frequent neoplasm found in AIDS patients. The disease is often disseminated and preferentially involves the skin and the lymphatic and digestive systems. Hepatosplenic involvement which is considered as a frequent autopsy finding is rarely diagnosed at life. A 27-year-old male HIV posit
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) for the treatment of human immunodeficiency virus type 1 (HIV-1) infections: strategies to overcome drug resistance development.: Med Res Rev. 1996 Mar;16(2):125-57. Unique Identifier : AIDSLINE MED/96249959; de Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
[A study of STD patients and their sexual behavior. Safer sex after interviews prior to journey abroad]: Lakartidningen. 1996 Feb 28;93(9):789-92. Unique Identifier : AIDSLINE MED/96248651; Ramstedt K; Karlsson AC; Lundin L; Hallhagen G; Toshach B; Smittskyddsinstitutet, Stockholm.
Transmission of HIV-1 by human bite [letter]: Lancet. 1996 Jun 22;347(9017):1762. Unique Identifier : AIDSLINE MED/96256427; Vidmar L; Poljak M; Tomazic J; Seme K; Klavs I
No relationship between HTLV-1 infection and filariasis--Serological study on patients with filariasis in Recife, Brazil.: Microbiol Immunol. 1995;39(11):917-9. Unique Identifier : AIDSLINE MED/96245553; Linhares MI; Malagueno E; Carvalho LB Jr; de Oliveira VF; Minamishima Y; Laboratorio de Imunopatologia Keizo Asami, Universidade Federal; de Pernambuco, Recife, Brazil.; The seroprevalence of antibodies against human T-cell leukemia virus was determined by ELISA in 68 patients with filarial infestation living in an endemic area. The total seropositivity was 2.9% and the HTLV-1-positive cases were detected in 2 microfilaremic patients 12 and 40 years old. This value is very close to th
Managing HIV. Part 6: People living with HIV. 6.1 Men and HIV.: Med J Aust. 1996 Jun 3;164(11):666-8. Unique Identifier : AIDSLINE MED/96257304; Pethebridge AM; Plummer DC; National Centre for Epidemiology and Population Health,; Australian National University, Canberra.; The medical management of the HIV-infected man is covered throughout Managing HIV. Understanding the sexuality of men is a crucial factor in understanding the HIV pandemic.
Managing HIV. Part 6: People living with HIV. 6.2 Women with HIV.: Med J Aust. 1996 Jun 3;164(11):669-71. Unique Identifier : AIDSLINE MED/96257305; Mijch AM; Clezy K; Furner V; Fairfield Hospital, Melbourne, VIC, NSW.; Gay men with HIV often belong to strong mutually supportive groups, but many women with HIV experience the disease in relative isolation. Informed primary care doctors can make a valuable difference to their management.
Managing HIV. Part 6: People living with HIV. 6.3 Children with HIV.: Med J Aust. 1996 Jun 3;164(11):672-9. Unique Identifier : AIDSLINE MED/96257306; Ziegler JB; Blanche S; Loh R; Department of Immunology and Allergy, Sydney Children's Hospital,; NSW.; Sometimes the diagnosis of HIV in a child is the first sign that other family members are affected by the virus. The immature immune system of children responds to HIV infection differently to that of adults. Disease progression is rapid in some, but most progress to AIDS at a similar or slower rate than do adults. A
['95 pneumology update. Progress and prospects in pneumology. Paradigm of change--II]: Med Klin. 1996 Apr 1;91 Suppl 1:103-17. Unique Identifier : AIDSLINE MED/96222202; Kroegel C; Buhl R; Muller-Querheim J; Wertzel H; Rabe K; Swoboda L; Matthys H; Hasse J; Magnussen H; Virchow JC; Abteilung Pneumologie, Medizinische Kliniken,; Albert-Ludwigs-Universitat, Freiburg.
[Clinical infectiology--I. Diagnosis, pathogen spectrum and resistance]: Med Klin. 1996 Apr 1;91 Suppl 1:166-75. Unique Identifier : AIDSLINE MED/96222208; Schrappe M; Medizinische Klinik I, Universitat Koln.
[Gastroenterology update]: Med Klin. 1996 Apr 1;91 Suppl 1:65-71. Unique Identifier : AIDSLINE MED/96222198; Layer P; Grandt D; Goebell H; Abteilung fur Gastroenterologie, Medizinische; Universitatsklinik, Essen.
[1995 gastroenterology update--I]: Med Klin. 1996 Apr 1;91 Suppl 1:73-80. Unique Identifier : AIDSLINE MED/96222199; Layer P; Brambs HJ; Ell C; Fischbach W; Fleig WE; Scholmerich J; Zirngibl H; Abteilung fur Gastroenterologie, Universitatsklinikum, Essen.
A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes.: Mol Cell Biol. 1996 Apr;16(4):1283-94. Unique Identifier : AIDSLINE GENBANK/D78261; Yamagata T; Nishida J; Tanaka S; Sakai R; Mitani K; Yoshida M; Taniguchi T; Yazaki Y; Hirai H; Third Department of Internal Medicine, Tokyo University, Japan.; We have isolated a novel cDNA clone encoding interferon (IFN) consensus sequence-binding protein in adult T-cell leukemia cell line or activated T cells (ICSAT); this protein is the human homolog of the recently cloned Pip/LSIRF. ICSAT is structurally most closely related to the previously cloned ICSBP, a member of th
Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability.: Mol Cell Biol. 1996 Apr;16(4):1401-9. Unique Identifier : AIDSLINE MED/96239494; Lin R; Beauparlant P; Makris C; Meloche S; Hiscott J; Lady Davis Institute for Medical Research, Sir Mortimer B. Davis; Jewish General Hospital, Montreal, Quebec, Canada.; The NF-kappaB/Rel transcription factors participate in the activation of immune system regulatory genes and viral early genes including the human immunodeficiency virus type 1 long terminal repeat. NF-kappaB/Rel proteins are coupled to inhibitory molecules, collectively termed IkappaB, which are responsible for cytopl
Role of polyadenylation in nucleocytoplasmic transport of mRNA.: Mol Cell Biol. 1996 Apr;16(4):1534-42. Unique Identifier : AIDSLINE MED/96239508; Huang Y; Carmichael GC; Department of Microbiology, University of Connecticut Health; Center, Farmington, 06030, USA.; To examine the role of polyadenylation in the nuclear export of mRNA, we have replaced the poly(A) signal in a Rev-responsive human immunodeficiency virus type 1-based reporter gene with a cis-acting hammerhead ribozyme. Transcripts from this gene thus acquire a 3 terminus by cis-ribozyme cleavage rather than by poly
Transcriptional activation of RNA polymerase III-dependent genes by the human T-cell leukemia virus type 1 tax protein.: Mol Cell Biol. 1996 Apr;16(4):1777-85. Unique Identifier : AIDSLINE MED/96239534; Gottesfeld JM; Johnson DL; Nyborg JK; Department of Molecular Biology, The Scripps Research Institute,; La Jolla, California 92037, USA.; The human T-cell leukemia virus-encoded tax protein is a potent activator of many viral and cellular genes transcribed by RNA polymerase II. We find that both chromatin and cell extracts derived from human T-cell leukemia virus type 1-infected human T lymphocytes support higher levels of 5S rRNA and tRNA gene transcri
Seroconversion to antibodies against Kaposi's sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi's sarcoma.: N Engl J Med. 1996 Jul 25;335(4):233-41. Unique Identifier : AIDSLINE MED/96266385; Gao SJ; Kingsley L; Hoover DR; Spira TJ; Rinaldo CR; Saah A; Phair J; Detels R; Parry P; Chang Y; Moore PS; Division of Epidemiology, School of Public Health, Columbia; University, New York, NY 10032, USA.; BACKGROUND: If Kaposi s sarcoma-associated herpesvirus (KSHV) is the cause of Kaposi s sarcoma, serologic evidence of infection should be present in patients before the disease develops. METHODS: Using an immunoblot assay for two latent nuclear antigens of KSHV, we tested serum samples from homosexual male patients wi
A drumstick? [letter]: N Engl J Med. 1996 Jul 25;335(4):291. Unique Identifier : AIDSLINE MED/96266409; Kessler L
WW domains and retrovirus budding [letter]: Nature. 1996 Jun 27;381(6585):744-5. Unique Identifier : AIDSLINE MED/96267000; Garnier L; Wills JW; Verderame MF; Sudol M
HIV therapy--what's new? [letter]: N Z Med J. 1996 May 10;109(1021):172. Unique Identifier : AIDSLINE MED/96257331; Chew GS
Infected surgeons.: N Z Med J. 1996 May 24;109(1022):177-8. Unique Identifier : AIDSLINE MED/96257337
AIDS [news]: N Z Med J. 1996 May 24;109(1022):196. Unique Identifier : AIDSLINE MED/96257351
Extensive vascular calcification in a patient with perinatally acquired AIDS.: Pediatr Radiol. 1996;26(5):365-6. Unique Identifier : AIDSLINE MED/96270095; Marquis JR; D'Cruz C; Department of Radiology, Children's Hospital of New Jersey,; United Hospitals Medical Center, 15 South Ninth Street, Newark,; NJ 07107, USA.; Extensive vascular calcification in an 8-year-old girl with perinatally acquired AIDS is reported. Complicating factors included cardiomyopathy, chronic lung disease, disseminated Mycobacterium avium complex (MAC), and wasting syndrome with total nutrition dependence. Plain abdominal films and CT of the abdomen immedi
Combination therapy with stavudine and didanosine in children with advanced human immunodeficiency virus infection: pharmacokinetic properties, safety, and immunologic and virologic effects.: Pediatrics. 1996 Jun;97(6 Pt 1):886-90. Unique Identifier : AIDSLINE MED/96237970; Kline MW; Fletcher CV; Federici ME; Harris AT; Evans KD; Rutkiewicz VL; Shearer WT; Dunkle LM; Department of Pediatrics, Baylor College of Medicine, Houston, TX; 77030, USA.; OBJECTIVES. To obtain preliminary information on the pharmacokinetic properties, tolerance, safety, and antiviral activity of combination therapy with stavudine and didanosine in children with advanced
Varicella vaccination [letter]: Pediatrics. 1996 Jun;97(6 Pt 1):932. Unique Identifier : AIDSLINE MED/96237988; May DL
The basic domain/leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE-like sequences containing an ACGT core.: Nucleic Acids Res. 1996 May 15;24(10):1855-64. Unique Identifier : AIDSLINE MED/96226171; Clauss IM; Chu M; Zhao JL; Glimcher LH; Department of Cancer Biology, Harvard School of Public Health,; Boston, MA 02115-6023, USA.; The transcription factor hXBP-1 belongs to the family of basic region/leucine zipper (bZIP) proteins and interacts with the cAMP responsive element (CRE) of the major histocompatibility complex (MHC) class II A alpha, DR alpha and DP beta genes. However, the developmental expression of hXBP-1 as revealed by in situ hy
A nuclear matrix-specific factor that binds a specific segment of the negative regulatory element (NRE) of HIV-1 LTR and inhibits NF-kappa(B) activity.: Nucleic Acids Res. 1996 May 15;24(10):1895-900. Unique Identifier : AIDSLINE MED/96226176; Hoover T; Mikovits J; Court D; Liu YL; Kung HF; Raziuddin; Intramural Research Support Program, SAIC/Frederick, Frederick,; MD 21702-1201, USA.; The negative regulatory element (NRE) of human immunodeficiency virus type-1 (HIV-1) long terminal repeat (LTR) is a defined region that has been reported to downregulate LTR-directed HIV gene expression. However, information on the precise role of this region in regulating HIV gone transcription is lacking. We have i
Fusion with an RNA binding domain to confer target RNA specificity to an RNase: design and engineering of Tat-RNase H that specifically recognizes and cleaves HIV-1 RNA in vitro.: Nucleic Acids Res. 1996 May 15;24(10):1908-12. Unique Identifier : AIDSLINE MED/96226178; Melekhovets YF; Joshi S; Department of Microbiology, Faculty of Medicine, University of; Toronto, Ontario, Canada.; A target RNA/DNA-specific nuclease could be constructed if a specific RNA/DNA binding domain allowing target RNA/DNA recognition was fused to a (deoxy)ribonucleolytic domain allowing target RNA/ DNA cleavage. The design and construction of such a chimeric enzyme could be of value for both basic research involving stru
[Cytokines in persons infected with HIV and patients with AIDS]: Postepy Hig Med Dosw. 1995;49(1):125-35. Unique Identifier : AIDSLINE MED/96254191; Piasecki E; The cytokine system is affected by human immunodeficiency virus. The virus stimulates or inhibits the production of various cytokines. On the other hand, many cytokines may interfere with HIV replication. Interferons (mainly alpha- and beta-type) inhibit and tumor necrosis factors stimulate the virus replication in vi
[Use of anti-H-Y/Db transgenic mice in studies on T-lymphocyte development and mechanisms of leukemogenesis]: Postepy Hig Med Dosw. 1995;49(1):61-5. Unique Identifier : AIDSLINE MED/96254184; Matuszyk J; Laboratorium Immunologii Komorkowej.; During the development of T cells in the thymus, the alpha beta T-cell receptor (TCR) mediated interactions of immature CD4+ CD8+ cells with thymic major histocompatibility complex (MHC) molecules in the absence of specific antigens are required for their survival and further maturation (positive selection) whereas in
[Pentoxifylline]: Postepy Hig Med Dosw. 1995;49(2):201-20. Unique Identifier : AIDSLINE MED/96254198; Paradowski PT; Zeman K; Klinika Chirurgii Urazowej i Ortopedii Instytutu Chirurgii,; Szpital Kliniczny Wojskowej Akademii Medycznej w Lodzi.; Pentoxifylline (PTX), methylxanthine derivative and phosphodiesterase inhibitor, has been in use for more than 20 years (with minimal side effects) for the potent hemorrheologic properties and was recently discovered to have influence on function of some immune cells and production of cytokines. Human and animal studi
[Biological properties and therapeutic use of interleukin 2 (IL-2)]: Postepy Hig Med Dosw. 1995;49(3):367-93. Unique Identifier : AIDSLINE MED/96254208; Robak T; II Klinika Chorob Wewnetrznych Akademii Medycznej w Lodzi.; A cytokine produced by the subpopulation of activated helper lymphocytes T has been called interleukin-2 ( IL-2 ). The obtaining of recombinant cytokine has facilitated the study of its biological properties and its application in the treatment of certain neoplastic and
[Tuberculosis in patients with HIV infections and AIDS]: Probl Tuberk. 1996;(2):16-7. Unique Identifier : AIDSLINE MED/96222214; Alekseeva LP; Gorbacheva ES; Gruzdev VM; As shown by tuberculosis screening in HIV-infected and AIDS subjects performed in the Moscow Anti-AIDS Center from 1989-1994, tuberculosis morbidity in the above subjects is 17.3 per 1,000. Mean age of the tuberculosis subjects was 34 years. Most of them were males with acute generalized pulmonary tuberculosis which c
[Extra meningeal cryptococcosis in a patient with AIDS]: Rev Med Chil. 1995 Aug;123(8):1009-12. Unique Identifier : AIDSLINE MED/96195979; Srur E; Misad C; Henriquez A; Servicio de Medicina, Hospital San Juan de Dios, Santiago de; Chile.; We report a young homosexual male with AIDS that presented a systemic Cryptococcus neoformans infection. He had skin, lymph node and colonic involvement but the central nervous system was spared. Treatment was started with amphotericin B, achieving a good remission of skin lesions. However, malaise and digestive sympt
[Resisting AIDS?]: Rev Med Suisse Romande. 1996 Mar;116(3):229-30. Unique Identifier : AIDSLINE MED/96234642; Bonard EC
Murine acariasis. II. Immunological dysfunction and evidence for chronic activation of Th-2 lymphocytes.: Scand J Immunol. 1996 Jun;43(6):604-12. Unique Identifier : AIDSLINE MED/96257892; Jungmann P; Freitas A; Bandeira A; Nobrega A; Coutinho A; Marcos MA; Minoprio P; Unite d'Immunobiologie, CNRS URA 1961 and 1960, Institut; Pasteur, Paris, France.; The authors describe the immunological profile of BALB/c mice with Mite-Associated Ulcerative Dermatitis (MAUD)-like disease, due to Myocoptes musculinus (Koch 1844) infestation. The disease probably involves allergic mechanisms and is characterized by erythematous and pruritic skin lesions, widespread hair loss, lymp
Heterogeneous expression of recombination activating genes and surface CD5 in CD3low CD4+ CD8+ thymocytes.: Scand J Immunol. 1996 Jun;43(6):619-25. Unique Identifier : AIDSLINE MED/96257894; Sheard M; Sugaya K; Furuta M; Tsuda S; Takahama Y; Masaryk Memorial Cancer Institute, Brno, Czech Republic.; Clonal selection in the thymus occurs mostly in the CD4+ CD8+ (double positive; DP) stage. Within DP thymocytes, cells in the CD3low subset are believed to be involved in clonal selection, and this subset is generally considered as a homogeneous population. T-cell antigen-receptor (TCR) signals on DP thymocytes are kn
Activation of cloned human CD4+ Th1 and Th2 cells by blood dendritic cells.: Scand J Immunol. 1996 Jun;43(6):646-51. Unique Identifier : AIDSLINE MED/96257898; Roth R; Spiegelberg HL; Department of Pediatrics, University of California at San Diego,; School of Medicine, La Jolla 92093-0609, USA.; Dendritic cells (DC) have been reported to be the most potent antigen-presenting cells (APC) for the activation of naive T cells and to be 10-100-fold more potent APC than monocytes (M phi) in the mixed lymphocyte reaction. In this study the authors compared human blood DC with M phi and B cells for their ability to a
The effects of mitogens, IL-2 and anti-CD3 antibody on the T-cell receptor V beta repertoire.: Scand J Immunol. 1996 Jun;43(6):652-61. Unique Identifier : AIDSLINE MED/96257899; Jason J; Inge KL; Immunology Branch, Centers for Disease Control and Prevention; (CDC), Atlanta 30333, USA.; Phytohaemagglutinin (PHA), Concanavalin A (Con A), interleukin-2 ( IL-2 ), and monoclonal antibodies to CD3 (CD3MoAbs) are used for the assessment of the T-cell receptor (TCR) BV gene family expression in autoimmune disorders and multiple sclerosis, and to produce clones
Prevalence and determinants of anti-HCV seropositivity and of HCV genotype among intravenous drug users in Berlin.: Scand J Infect Dis. 1995;27(4):331-7. Unique Identifier : AIDSLINE MED/96108296; Stark K; Schreier E; Muller R; Wirth D; Driesel G; Bienzle U; Institute of Tropical Medicine, Free University, Berlin, Germany.; A cross-sectional study was carried out to identify risk factors for seropositivity for antibodies against hepatitis C virus (HCV) and to assess to the distribution and determinants of HCV genotypes among intravenous drug users (IVDUs). The study population consisted of 405 IVDUs. Serum specimens were tested for serom
Coxiella burnetii infection in subjects with HIV infection and HIV infection in patients with Q fever.: Scand J Infect Dis. 1995;27(4):344-6. Unique Identifier : AIDSLINE MED/96108298; Montes M; Cilla G; Marimon JM; Diaz de Tuesta JL; Perez-Trallero E; Servicio de Microbiologia y Unidad de Epidemiologia Infecciosa,; Facultad de Medicina, Hospital NS Aranzazu, San Sebastian,; Spain.; The objective of the study was to determine whether HIV infection favors the acquisition of Coxiella burnetii infection or increases the frequency of symptomatic Coxiella infections. A total of 754 subjects were tested for Coxiella antibodies: 596 intravenous drug users (IVDUs) (306 HIV-infected IVDUs matched by aged
Persistent reduction in lung function after Pneumocystis carinii pneumonia in AIDS patients.: Scand J Infect Dis. 1995;27(4):351-5. Unique Identifier : AIDSLINE MED/96108300; Nelsing S; Jensen BN; Backer V; Department of Infectious Diseases, Rigshospitalet, Copenhagen,; Denmark.; By means of serial lung function tests we examined the changes in lung function