Boromycin, an anti-HIV antibiotic. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Boromycin, an anti-HIV antibiotic.

Biosci Biotechnol Biochem. 1996 Jun;60(6):1036-7. Unique Identifier : AIDSLINE MED/96294286
Kohno J; Kawahata T; Otake T; Morimoto M; Mori H; Ueba N; Nishio M; Kinumaki A; Komatsubara S; Kawashima K; Lead Generation Research Laboratory at Toda, Tanabe Seiyaku Co.,; Ltd., Saitama, Japan.

Abstract: The polyether-macrolide antibiotic, boromycin, was isolated as a potent anti-human immunodeficiency virus (HIV) antibiotic from a fermentation broth of Streptomyces sp. A-3376. Boromycin was found to strongly inhibit the replication of the clinically isolated HIV-1 strain as well as the cultured strain in in vitro laboratory experiments. The mechanism for the anti-HIV activity of boromycin is suggested to involve blocking the later stage of HIV infection, and probably the maturity step for replication of the HIV molecule.
Keywords: Antibiotics/CHEMISTRY/*PHARMACOLOGY Antiviral Agents/CHEMISTRY/*PHARMACOLOGY Borates/CHEMISTRY/*PHARMACOLOGY Cell Line Dextran Sulfate/PHARMACOLOGY Glucosamine/ANALOGS & DERIVATIVES/PHARMACOLOGY Glycoside Hydrolases/ANTAGONISTS & INHIB HIV-1/*DRUG EFFECTS HIV-2/*DRUG EFFECTS Human Molecular Structure RNA-Directed DNA Polymerase/DRUG EFFECTS/METABOLISM Streptomyces/METABOLISM Support, Non-U.S. Gov't JOURNAL ARTICLEKWDantibiotics/chemistry/KWDpharmacologyantiviralagents/chemistry/KWDpharmacologyborates/chemistry/KWDpharmacologycelllinedextransulfate/pharmacologyglucosamine/analogs&derivatives/pharmacologyglycosidehydrolases/antagonists&inhibhiv-1/KWDdrugeffectshiv-2/KWDdrugeffectshumanmolecularstructurerna-directeddnapolymerase/drugeffects/metabolismstreptomyces/metabolismsupport,non-uKWDsKWDgov'tjournalarticle
961130
M96B1869

Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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