A decade of research on the natural history of HIV infection: Part 2. Cofactors. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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A decade of research on the natural history of HIV infection: Part 2. Cofactors.

Clin Invest Med. 1996 Apr;19(2):121-30. Unique Identifier : AIDSLINE MED/96260550
Strathdee SA; Hogg RS; O'Shaughnessy MV; Montaner JS; Schechter MT; British Columbia Centre for Excellence in HIV/AIDS.

Abstract: Cofactors of HIV disease may be considered risk modifiers that are causally related to future disease course. The search for potential cofactors, of viral, host or environmental origin, may provide avenues for altering the natural history of HIV infection. Potential viral cofactors include viral strains, such as syncytium-inducing and nonsyncytium-inducing variants, and strains that are resistant to specific antiretroviral therapies. Although there is strong evidence that sexually transmitted diseases that lead to genital ulcers or abrasions are important cofactors of HIV transmission, their role as cofactors in HIV disease progression is less clear. Further study of agents such as human herpesviruses 6 and 8 and hepatitis C may shed light on the role of other infectious agents in progressive HIV disease. Far less research has been conducted on behavioural, genetic and sociodemographic factors that may influence HIV disease progression rates. Since current anti-HIV therapies do not offer a cure, but only a means of prolonging life, the identification of possible cofactors is critical.
Keywords: Comorbidity Demography Disease Progression Human HIV Infections/EPIDEMIOLOGY/*PHYSIOPATHOLOGY Nutrition Phenotype Risk Factors Sexually Transmitted Diseases Socioeconomic Factors Stress, Psychological Substance Abuse Support, Non-U.S. Gov't Virus Diseases JOURNAL ARTICLE REVIEW REVIEW, ACADEMICKWDcomorbiditydemographydiseaseprogressionhumanhivinfections/epidemiology/KWDphysiopathologynutritionphenotyperiskfactorssexuallytransmitteddiseasessocioeconomicfactorsstress,psychologicalsubstanceabusesupport,non-uKWDsKWDgov'tvirusdiseasesjournalarticlereviewreview,academic
961130
M96B1840

Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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