The solution structure of the bovine leukaemia virus matrix protein and similarity with lentiviral matrix proteins. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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The solution structure of the bovine leukaemia virus matrix protein and similarity with lentiviral matrix proteins.

EMBO J. 1996 Jul 1;15(13):3267-74. Unique Identifier : AIDSLINE PDB
Matthews S; Mikhailov M; Burny A; Roy P; Department of Biochemistry, Imperial College of Science,; Technology and Medicine, University of London, UK.; sjm@bioch.ox.ac.uk

Abstract: In the mature virion, retroviral matrix proteins are found in association with the inner face of the viral membrane. They play a critical role in determining the morphogenesis of virus assembly. We have determined the three-dimensional solution structure of the bovine leukaemia virus (BLV) matrix protein by heteronuclear nuclear magnetic resonance. The protein contains four principal helices that are joined by short, partially structured loops. Despite no sequence similarity with the lentiviruses, the structure shows an intriguing homology with the equivalent protein from the human and simian immunodeficiency viruses. A root-mean-square deviation of 3.78 angstrom is observed over the backbone atoms of 36 equivalent helical positions. The similarity implies a possible common assembly unit for the matrix proteins of type C retroviruses.
Keywords: Amino Acid Sequence Gene Products, gag/*CHEMISTRY/GENETICS Glutathione Transferases/GENETICS Lentivirus/*CHEMISTRY/GENETICS Molecular Sequence Data Nuclear Magnetic Resonance Protein Conformation Recombinant Fusion Proteins/CHEMISTRY/GENETICS Sequence Homology, Amino Acid Support, Non-U.S. Gov't Viral Matrix Proteins/*CHEMISTRY/GENETICS JOURNAL ARTICLEKWDaminoacidsequencegeneproducts,gag/KWDchemistry/geneticsglutathionetransferases/geneticslentivirus/KWDchemistry/geneticsmolecularsequencedatanuclearmagneticresonanceproteinconformationrecombinantfusionproteins/chemistry/geneticssequencehomology,aminoacidsupport,non-uKWDsKWDgov'tviralmatrixproteins/KWDchemistry/geneticsjournalarticle
961130
M96B1832

Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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