Expression of L-selectin (CD62L) discriminates Th1- and Th2-like cytokine-producing memory CD4+ T cells.

Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

Expression of L-selectin (CD62L) discriminates Th1- and Th2-like cytokine-producing memory CD4+ T cells.

Immunology. 1996 Feb;87(2):186-90. Unique Identifier : AIDSLINE MED/96245969
Kanegane H; Kasahara Y; Niida Y; Yachie A; Sughii S; Takatsu K; Taniguchi N; Miyawaki T; Department of Pediatrics, School of Medicine, Kanazawa; University, Japan.

Abstract: Human memory (CD45RO+) CD4+ T cells can be distinguished into two subpopulations on the basis of expression of the lymph node homing receptor, L-selectin (CD62L). In a prior study we showed that human L-selectin-positive memory T-helper (Th) cells promote the maturation of IgG- and IgA-producing cells by naive B cells. To further elucidate the contribution of memory CD4+ T cells to B-cell differentiation, human memory CD4+ T cells with or without L-selectin expression were evaluated for production of cytokines that participate in regulation of immunoglobulin production. It was found that L-selectin-positive human memory CD4+ T cells produce mainly interleukin (IL)-4 and IL-5, whereas L-selectin-negative CD4+ T cells produce mainly interferon-gamma (IFN-gamma). This profile of cytokine expression coincides with the profile that distinguishes Th1 and Th2 subsets. In contrast to the murine system, IL-10 production was similarly contributed by human L-selectin-positive and -negative memory CD4+ T-cell subpopulations. These results suggest that the human L-selectin-negative and -positive subpopulations of human memory CD4+ T cells contain Th1-like and Th2-like cytokine-producing cells, respectively.

Keywords: Adult Base Sequence Cell Culture Cytokines/*BIOSYNTHESIS Fluorescent Antibody Technique Human *Immunologic Memory Interferon Type II/BIOSYNTHESIS Interleukins/BIOSYNTHESIS L-Selectin/*BLOOD Molecular Sequence Data Polymerase Chain Reaction Support, Non-U.S. Gov't Th1 Cells/*IMMUNOLOGY Th2 Cells/*IMMUNOLOGY JOURNAL ARTICLE
961130
M96B1814

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