Colocalisation of human immunodeficiency virus and human cytomegalovirus infection in brain autopsy tissue from AIDS patients. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Colocalisation of human immunodeficiency virus and human cytomegalovirus infection in brain autopsy tissue from AIDS patients.

Ir J Med Sci. 1996 Apr-Jun;165(2):133-8. Unique Identifier : AIDSLINE MED/96293026
Balluz IM; Farrell MA; Kay E; Staunton MJ; Keating JN; Sheils O; Cosby SL; Mabruk MJ; Sheahan BJ; Atkins GJ; Department of Microbiology, Moyne Institute of Preventive; Medicine, Trinity College, Dublin, Northern Ireland.

Abstract: We have examined 26 human AIDS brains obtained at post mortem for infection by human immunodeficiency virus (HIV) and human cytomegalovirus (HCMV), and for dual infection of cells by both viruses. The techniques used were enzyme-linked immunocytochemistry for HCMV and in situ hybridisation using a cDNA probe for HIV. Using these techniques, HCMV infection was detected in 14 brains, HIV infection in 14 brains, and coinfection with HIV and HCMV in 7 brains. Four case of dual HIV/HCMV infection were found where no colocalisation could be detected. In randomly chosen dually infected areas 19.2% of infected cells were coinfected with both viruses. Although cells identified morphologically as macrophages were the most common infected cell type, astrocytes and neurons were both singly and doubly infected with HIV and HCMV. Complete clinical data were available for 4 of the 7 cases with coinfection and each had AIDS dementia complex.
Keywords: Adolescence Adult Autopsy AIDS-Related Opportunistic Infections/*PATHOLOGY Brain/PATHOLOGY/*VIROLOGY Cytomegalovirus/ISOLATION & PURIF Cytomegalovirus Infections/*PATHOLOGY Female Human HIV/ISOLATION & PURIF Immunohistochemistry In Situ Hybridization Male Middle Age Support, Non-U.S. Gov't JOURNAL ARTICLEKWDadolescenceadultautopsyaids-relatedopportunisticinfections/KWDpathologybrain/pathology/KWDvirologycytomegalovirus/isolation&purifcytomegalovirusinfections/KWDpathologyfemalehumanhiv/isolation&purifimmunohistochemistryinsituhybridizationmalemiddleagesupport,non-uKWDsKWDgov'tjournalarticle
961130
M96B1804

Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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