Analysis of T cell receptor V beta expression in rabbit T lymphocytes induced to proliferate by an HTLV-I-transformed leukemogenic T cell line. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Analysis of T cell receptor V beta expression in rabbit T lymphocytes induced to proliferate by an HTLV-I-transformed leukemogenic T cell line.

J Cancer Res Clin Oncol. 1996;122(8):458-64. Unique Identifier : AIDSLINE MED/96328340
Isono T; Isegawa Y; Seto A; Department of Microbiology, Shiga University of Medical Science,; Japan.

Abstract: Peripheral blood lymphocytes (PBL) from rabbits of the Chbb:HM strain proliferated in coculture with an X-ray-irradiated HTLV-I-transformed leukemogenic cell line of (B/J x Chbb:HM) F1 origin, whereas PBL from rabbits of the B/J and F1 strains hardly proliferated at all in co-culture with the same cell line. A proviral HTLV-I genome was detected in high-molecular-mass DNA from these proliferating cells. An analysis of T cell receptor V beta expression revealed that these lymphocytes were of restricted V beta subfamilies, suggesting that the preferential stimulation and transformation of lymphocytes occurred in this co-culture. Staphylococcal enterotoxins similarly stimulated lymphocytes and the proliferated lymphocytes were mostly of distinct V beta subfamilies depending on stimulator enterotoxins. These results suggested that the leukemogenic cell line possesses an antigen that preferentially stimulates lymphocytes of restricted V beta subfamilies.
Keywords: Animal Base Sequence Cell Line, Transformed Cell Transformation, Viral/*IMMUNOLOGY Enterotoxins/IMMUNOLOGY HTLV-I/*GENETICS Leukemia/IMMUNOLOGY *Lymphocyte Transformation Molecular Sequence Data Rabbits Receptors, Antigen, T-Cell, alpha-beta/*ANALYSIS Superantigens/*ANALYSIS T-Lymphocytes/*IMMUNOLOGY JOURNAL ARTICLEKWDanimalbasesequencecellline,transformedcelltransformation,viral/KWDimmunologyenterotoxins/immunologyhtlv-i/KWDgeneticsleukemia/immunologyKWDlymphocytetransformationmolecularsequencedatarabbitsreceptors,antigen,t-cell,alpha-beta/KWDanalysissuperantigens/KWDanalysist-lymphocytes/KWDimmunologyjournalarticle
961130
M96B1799

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