Photoaccentuated erythroderma associated with CD4+ T lymphocytopenia: successful treatment with 5-methoxypsoralen and UVA, interferon alfa-2b, and extracorporeal photopheresis. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Photoaccentuated erythroderma associated with CD4+ T lymphocytopenia: successful treatment with 5-methoxypsoralen and UVA, interferon alfa-2b, and extracorporeal photopheresis.

J Am Acad Dermatol. 1996 Aug;35(2 Pt 2):291-4. Unique Identifier : AIDSLINE MED/96319546
Wolf P; Mullegger R; Cerroni L; Aigner R; Fueger G; Hofler G; Derbaschnig J; Kerl H; Department of Dermatology, Karl Franzens University, Graz,; Austria.

Abstract: We describe a 53-year-old HIV-negative white man who had chronic CD4+ T lymphocytopenia and photoaccentuated erythroderma with lymphoma-like histologic changes. The erythroderma completely responded to 5-methoxypsoralen and UVA (PUVA), interferon alfa-2b, and extracorporeal photopheresis. During therapy opportunistic skin infections, including tinea corporis, warts, and disseminated molluscum contagiosum, developed. Although the patient met the current definition of idiopathic CD4+ T lymphocytopenia (ICTL), we cannot rule out the possibility that this peripheral CD4+ T lymphocytopenia resulted from sequestration of CD4+ T lymphocytes in erythrodermic skin.
Keywords: Case Report Dermatitis, Exfoliative/DRUG THERAPY/*PATHOLOGY Human HIV Seronegativity Interferon Alfa-2b/*THERAPEUTIC USE Lymphoma, T-Cell, Cutaneous/PATHOLOGY Male Methoxsalen/*ANALOGS & DERIVATIVES/THERAPEUTIC USE Middle Age Molluscum Contagiosum/ETIOLOGY Opportunistic Infections/ETIOLOGY *Photopheresis Photosensitivity Disorders/DRUG THERAPY/*PATHOLOGY *PUVA Therapy Skin Neoplasms/PATHOLOGY Support, Non-U.S. Gov't T-Lymphocytopenia, Idiopathic CD4-Positive/DRUG THERAPY/ *PATHOLOGY Tinea/ETIOLOGY Warts/ETIOLOGY JOURNAL ARTICLEKWDcasereportdermatitis,exfoliative/drugtherapy/KWDpathologyhumanhivseronegativityinterferonalfa-2b/KWDtherapeuticuselymphoma,t-cell,cutaneous/pathologymalemethoxsalen/KWDanalogs&derivatives/therapeuticusemiddleagemolluscumcontagiosum/etiologyopportunisticinfections/etiologyKWDphotopheresisphotosensitivitydisorders/drugtherapy/KWDpathologyKWDpuvatherapyskinneoplasms/pathologysupport,non-uKWDsKWDgov'tt-lymphocytopenia,idiopathiccd4-positive/drugtherapy/KWDpathologytinea/etiologywarts/etiologyjournalarticle
961130
M96B1795

Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1996. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1996. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .