Characterization of a transcriptional attenuator within the 5' R region of the human T cell leukemia virus type 1. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Characterization of a transcriptional attenuator within the 5' R region of the human T cell leukemia virus type 1.

AIDS Res Hum Retroviruses. 1995 Sep;11(9):1123-9. Unique Identifier : AIDSLINE MED/96089220
Montagne J; Jalinot P; Laboratoire de Biologie Moleculaire et Cellulaire, CNRS UMR49,; Ecole Normale Superieure de Lyon, France.

Abstract: Several regulatory sequences have been characterized in the HTLV-I promoter. We report here identification of a sequence element downstream of the transcriptional start site within the first 52 nucleotides of the 5' R region, which acts negatively on the activity of the HTLV-I promoter. Determination of the half-lives of the RNAs either including or lacking this sequence element showed that the observed effect intervenes at the transcriptional level. This negative element does not affect basal activity of the HTLV-I TATA box, but down-regulates transcription induced by strong activators. Thus, we propose that this so-called negative regulatory sequence functions as an attenuator of transcription.
Keywords: Actins/GENETICS Base Sequence Down-Regulation (Physiology) Genes, Regulator Genes, Reporter *Genes, Viral Globin/GENETICS Hela Cells Human HTLV-I/*GENETICS Molecular Sequence Data Nucleic Acid Conformation Promoter Regions (Genetics) RNA, Viral/CHEMISTRY/GENETICS Support, Non-U.S. Gov't Trans-Activation (Genetics) JOURNAL ARTICLEKWDactins/geneticsbasesequencedown-regulation(physiology)genes,regulatorgenes,reporterKWDgenes,viralglobin/geneticshelacellshumanhtlv-i/KWDgeneticsmolecularsequencedatanucleicacidconformationpromoterregions(genetics)rna,viral/chemistry/geneticssupport,non-uKWDsKWDgov'ttrans-activation(genetics)journalarticle
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M9651086

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