Hepatitis C virus genotypes and severity of chronic liver disease in haemophiliacs. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Hepatitis C virus genotypes and severity of chronic liver disease in haemophiliacs.

Br J Haematol. 1995 Nov;91(3):708-13. Unique Identifier : AIDSLINE MED/96048918
Tagariello G; Pontisso P; Davoli PG; Ruvoletto MG; Traldi A; Alberti A; Centre for Blood Diseases, Castelfranco Veneto Hospital, TV,; Italy.

Abstract: We studied the activity and stage of chronic liver disease in 45 HCV-seropositive/HIV-seronegative patients with severe haemophilia followed for at least 10 years. HCV-RNA was detected in serum in 36 patients (80%) Viraemic cases were further analysed for HCV genotypes: 10 (28%) were infected by type 1a, 10 (28%) by type 1b, seven (19%) by type 2, four (11%) by type 3, four (11%) had mixed infections (one by 1a + 1b, one by 1a + 2, one by type 2 + 3, and one by 1a + 2 + 3). ALT levels were within the normal range in 55% of the HCV-RNA negative patients but in only 11% of the viraemic cases. Results show a trend for higher levels of ALT in HCV-RNA-positive patients compared with those without viraemia (98 +/- 56 v 60 +/- 61), and particularly with patients with type 3 HCV infection (148 +/- 44). We suggest that a slow progression of chronic liver disease occurs in haemophilic HCV-positive/HIV-negative patients and conclude that presence of HCV-RNA in serum correlates well with cytolitic damage but, in the time-scale of our follow-up period, commonly used clinical-laboratory parameters cannot predict the chronic evolution of liver infection or identify differences in disease progression in relation to specific HCV subtypes.
Keywords: Adolescence Adult Base Sequence Child Chronic Disease Genotype Hemophilia/COMPLICATIONS/*VIROLOGY Hepatitis C/COMPLICATIONS/GENETICS Hepatitis C Viruses/*GENETICS Human Liver Diseases/COMPLICATIONS/*VIROLOGY Male Middle Age Molecular Sequence Data RNA, Viral/GENETICS Support, Non-U.S. Gov't JOURNAL ARTICLEKWDadolescenceadultbasesequencechildchronicdiseasegenotypehemophilia/complications/KWDvirologyhepatitisc/complications/geneticshepatitiscviruses/KWDgeneticshumanliverdiseases/complications/KWDvirologymalemiddleagemolecularsequencedatarna,viral/geneticssupport,non-uKWDsKWDgov'tjournalarticle
960530
M9651072

Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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