Infective complications after minor operations in patients infected with HIV: role of CD4 lymphocytes in prognosis.

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Infective complications after minor operations in patients infected with HIV: role of CD4 lymphocytes in prognosis.

Eur J Surg. 1995 Oct;161(10):721-3. Unique Identifier : AIDSLINE MED/96136956
Emparan C; Iturburu IM; Portugal V; Apecechea A; Bilbao JE; Mendez JJ; Department of Surgery, Universidad del Pais Vasco, General; Surgery B, Hospital de Basurto, Bilbao, Spain.

Abstract: OBJECTIVE: To find out the incidence of wound infection in patients with HIV and reduced counts of CD4 lymphocytes. DESIGN: Open study. SETTING: University hospital, Spain. SUBJECTS: 70 patients with HIV infection and enlarged lymph nodes. INTERVENTIONS: Biopsy of lymph nodes and withdrawal of a sample of blood for counts of CD4 lymphocytes and neutrophils. MAIN OUTCOME MEASURE: Development of infection at the biopsy site, and correlation of infecting organism with culture taken at the time of biopsy. RESULTS: Patients were divided into three groups depending on their CD4 count: more than 500 cells/ml (n = 26), 200-500 cells/ml (n = 24), and less than 200 cells/ml (n = 20). Their neutrophil counts were 5.1, 3.8, and 2.5 x 10(9)/1, respectively. There were found four wound infections (6%); 2 were in the group with more than 500 CD4 cells/ml, and these were caused by Staphylococcus aureus (which had been grown from nodes in 6 patients at the time of biopsy). The other 2 were in the group with less than 500 cells/ml and these were caused by Mycobacterium tuberculosis; cultures of the nodes had shown Staphylococcus epidermidis (n = 3) and M tuberculosis (n = 17). There were no infections in the group with 200-500 CD4 cells/ml, in which S epidermidis (n = 5) and M tuberculosis (n = 8) had been cultured from the lymph nodes. CONCLUSIONS: The CD4 count was of no prognostic importance in the development of wound infection, but severe depression of the CD4 count may increase the risk of atypical wound infections.

Keywords: Biopsy CD4 Lymphocyte Count CD4-Positive T-Lymphocytes/*PHYSIOLOGY Human HIV Infections/*IMMUNOLOGY Leukocyte Count Lymph Nodes/MICROBIOLOGY/PATHOLOGY Neutrophils Prognosis Staphylococcal Infections/IMMUNOLOGY/MICROBIOLOGY Surgical Wound Infection/*IMMUNOLOGY/MICROBIOLOGY Tuberculosis/IMMUNOLOGY/MICROBIOLOGY JOURNAL ARTICLE
960530
M9651061

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