MHC class I-selected CD4-CD8-TCR alpha beta+ T cells: an important source of IL-4. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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MHC class I-selected CD4-CD8-TCR alpha beta+ T cells: an important source of IL-4.

Braz J Med Biol Res. 1995 Aug;28(8):903-5. Unique Identifier : AIDSLINE MED/96098120
Leite-de-Moraes MC; Dy M; Universite Rene Descartes, Paris, France.

Abstract: Differentiation of naive CD4+ lymphocytes into either Th1 or Th2 cells is influenced by the cytokine present during initial antigen priming. IL-4 is the critical element in the induction of Th2 response; however, its origin during a primary immune response is not well-defined. Here, a novel source of IL-4, the class I-selected CD4-CD8-TCR alpha beta+ T cells, potentially implicated in the development of specific Th2 immune cells, is reviewed.
Keywords: Animal Cell Differentiation CD4-Positive T-Lymphocytes/*PHYSIOLOGY CD8-Positive T-Lymphocytes/*PHYSIOLOGY Genes, MHC Class I/*PHYSIOLOGY Interleukin-4/*PHYSIOLOGY Mice Receptors, Antigen, T-Cell, alpha-beta/*PHYSIOLOGY JOURNAL ARTICLE REVIEW REVIEW, TUTORIALKWDanimalcelldifferentiationcd4-positivet-lymphocytes/KWDphysiologycd8-positivet-lymphocytes/KWDphysiologygenes,mhcclassi/KWDphysiologyinterleukin-4/KWDphysiologymicereceptors,antigen,t-cell,alpha-beta/KWDphysiologyjournalarticlereviewreview,tutorial
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