L-cycloserine, an inhibitor of sphingolipid biosynthesis, inhibits HIV-1 cytopathic effects, replication, and infectivity.

Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

L-cycloserine, an inhibitor of sphingolipid biosynthesis, inhibits HIV-1 cytopathic effects, replication, and infectivity.

J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):137-41. Unique Identifier : AIDSLINE MED/96147313
Mizrachi Y; Lev M; Harish Z; Sundaram SK; Rubinstein A; Department of Pediatrics, Microbiology and Immunology, Albert; Einstein College of Medicine, Bronx, NY 10461, USA.

Abstract: Drugs that reduce viral production or prevent viral spread by interference with the host's cellular components are unlikely to induce resistance, in contrast to treatment modalities that interact with the HIV-1 life cycle. Two features make L-cycloserine (L-CS) a candidate drug of this kind: (a) L-CS is a potent inhibitor of the sphingolipid pathway (b) sphingolipids, galactocerebrosides, and sulfatides have been shown, by others, to bind gp120. In a feasibility and efficacy study, we have found that L-CS inhibits HIV-1 replication in a CD4+ lymphoid cell line (CEM) as documented by the reduction of syncytium formation, the number of HIV-1 infected cells, and p24 protein production. This observation may lead to a new strategy for the treatment of HIV-1 infection.

Keywords: Antimetabolites/*PHARMACOLOGY Cell Line Cycloserine/*PHARMACOLOGY Cytopathogenic Effect, Viral/DRUG EFFECTS CD4-Positive T-Lymphocytes/PHYSIOLOGY/VIROLOGY Fluorescent Antibody Technique Giant Cells Human HIV Core Protein p24/BIOSYNTHESIS HIV-1/*DRUG EFFECTS/PHYSIOLOGY Sphingolipids/*ANTAGONISTS & INHIB/BIOSYNTHESIS Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Virus Replication/*DRUG EFFECTS/PHYSIOLOGY JOURNAL ARTICLE
960530
M9651036

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