1996

Interferon-gamma-induced downregulation of CD4 inhibits the entry of human immunodeficiency virus type-1 in primary monocytes.: Pathobiology. 1995;63(2):93-9. Unique Identifier : AIDSLINE MED/96108566; Dhawan S; Heredia A; Wahl LM; Epstein JS; Meltzer MS; Hewlett IK; Laboratory of Molecular Virology, Food and Drug Administration,; Rockville, Md., USA.; We have previously shown that the treatment of monocytes with interferon-gamma (IFN-gamma) prior to exposure with human immunodeficiency virus type-1 (HIV) results in complete inhibition of HIV infection of monocytes. In the present report, we have extended this study to obtain information on the mechanism(s) underlyi
The accurate diagnosis of oral lesions in human immunodeficiency virus infection. Impact on medical staging.: Arch Otolaryngol Head Neck Surg. 1996 Jan;122(1):68-73. Unique Identifier : AIDSLINE MED/96133394; Cruz GD; Lamster IB; Begg MD; Phelan JA; Gorman JM; el-Sadr W; New York City (NY) Department of Health, USA.; OBJECTIVE: To compare identification of oral candidiasis (OC) and oral hairy leukoplakia (OHL) by medical examiners and oral/dental examiners and to assess the impact of these diagnoses on the medical staging of the human immunodeficiency virus (HIV). DESIGN: Retrospective analysis of data collected by medical and ora
Analysis and localization of cyclophilin A found in the virions of human immunodeficiency virus type 1 MN strain.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1003-6. Unique Identifier : AIDSLINE MED/96089206; Ott DE; Coren LV; Johnson DG; Sowder RC 2nd; Arthur LO; Henderson LE; AIDS Vaccine Program, National Cancer Institute, Frederick Cancer; Research and Development Center, Maryland 21702-1201, USA.; Previous reports have shown that cyclophilin A (CyPA) is found to be specifically associated with human immunodeficiency virus type-1 (HIV-1) virions and is required for infectivity (Franke et al. Nature 372:359; Thali et al. Nature 372:363). We have examined CyPA associated with HIV-1MN virions. Virions from infected
HIV acquires functional adhesion receptors from host cells.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1007-13. Unique Identifier : AIDSLINE MED/96089207; Guo MM; Hildreth JE; Department of Pharmacology and Molecular Sciences, Johns Hopkins; University School of Medicine, Baltimore, Maryland 21205, USA.; CD4 is known to serve as the principal cellular receptor for HIV. However, several observations suggest that other molecules may be involved in infection of cells by HIV. Cell adhesion molecules and their ligands expressed on HIV-susceptible cells have been implicated in the biology of HIV in a number of studies. We h
Enhanced susceptibility to human immunodeficiency virus infection in CD4+ T lymphocytes genetically deficient in CD43.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1015-21. Unique Identifier : AIDSLINE MED/96089208; Srinivas RV; Su T; Trimble LA; Lieberman J; Ardman B; Department of Infectious Diseases, St. Jude Children's Research; Hospital, Memphis, Tennessee 38105, USA.; CD43 is a cell surface sialoglycoprotein expressed by most cells of hematopoietic origin, including all T lymphocytes. Elimination of CD43 expression by gene targeting in the CEM T cell line results in its increased homotypic adhesion and binding to HIV-1 gp120. Here we report that the CD43-negative CEM cells show inc
Kinetics of HIV infection of human placental syncytiotrophoblast cultures: an ultrastructural and immunocytochemical study.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1023-30. Unique Identifier : AIDSLINE MED/96089209; Fazely F; Fry GN; Thirkill TL; Hakim H; King BF; Douglas GC; Department of Medical Pathology, School of Medicine, University; of California, Davis 95616, USA.; We previously demonstrated that syncytiotrophoblast (ST) cells from term human placentas could be infected when cocultured with HIV-infected lymphocytic cells. Here, we have used fluorescence microscopy and transmission electron microscopy to examine the kinetics of this infection process. Molt-4 clone 8 cells infecte
Suppression of HIV replication in human monocyte-derived macrophages induced by granulocyte/macrophage colony-stimulating factor.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1031-8. Unique Identifier : AIDSLINE MED/96089210; Matsuda S; Akagawa K; Honda M; Yokota Y; Takebe Y; Takemori T; AIDS Research Center, National Institute of Health, Tokyo, Japan.; Susceptibility to HIV infection was examined in macrophages differentiated from human monocytes by macrophage colony-stimulating factor (M-CSF) or granulocyte/macrophage colony-stimulating factor (GM-CSF). The replication of macrophage-tropic human immunodeficiency virus type-1 (HIV-1), which was determined by reverse
HIV type 1 extracellular Tat protein stimulates growth and protects cells of BK virus/tat transgenic mice from apoptosis.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1039-48. Unique Identifier : AIDSLINE MED/96089211; Campioni D; Corallini A; Zauli G; Possati L; Altavilla G; Barbanti-Brodano G; Institute of Microbiology, School of Medicine, University of; Ferrara, Italy.; Cells from BKV/tat transgenic mice were characterized for their tumorigenic phenotype in nude and syngeneic BDF mice. The results indicate that the BKV/tat recombinant transgene has a weak tumorigenic potential, mostly predisposing to oncogenesis, and that second events are required for the development of tumorigenici
Iron chelation decreases NF-kappa B and HIV type 1 activation due to oxidative stress.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1049-61. Unique Identifier : AIDSLINE MED/96089212; Sappey C; Boelaert JR; Legrand-Poels S; Forceille C; Favier A; Piette J; Laboratory of Virology, University of Liege, Belgium.; An important aspect of human immunodeficiency virus (HIV-1) infection is the regulation of its expression by nuclear factor kappa B (NF-kappa B) through redox-controlled signal transduction pathways. In this study, we demonstrate that iron chelation by deferoxamine (DFO) protects against the cytotoxic and reactivating
Intracellular trafficking of the human immunodeficiency virus type 1 Rev protein: involvement of continued rRNA synthesis in nuclear retention.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1063-71. Unique Identifier : AIDSLINE MED/96089213; D'Agostino DM; Ciminale V; Pavlakis GN; Chieco-Bianchi L; Institute of Oncology, University of Padova, Italy.; We have explored the mechanism directing the intracellular trafficking and nucleolar accumulation of the human immunodeficiency virus type 1 (HIV-1) Rev protein. Treatment of Rev-expressing cells with mycophenolic acid, an inhibitor of inosine monophosphate dehydrogenase, resulted in a redistribution of Rev from the n
Development of a human thymic organ culture model for the study of HIV pathogenesis.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1073-80. Unique Identifier : AIDSLINE MED/96089214; Bonyhadi ML; Su L; Auten J; McCune JM; Kaneshima H; HIV Group, SyStemix, Inc., Palo Alto, California 94304, USA.; The development of effective therapies for the treatment of AIDS would be facilitated by a better understanding of HIV pathogenesis in vivo. While some aspects of pathogenesis may be assessed by standard tissue culture assays, in vivo animal models may provide clues to other aspects of HIV-mediated progression toward
Rapid molecular epidemiology of human immunodeficiency virus transmission.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1081-93. Unique Identifier : AIDSLINE MED/96089215; Delwart EL; Busch MP; Kalish ML; Mosley JW; Mullins JI; Aaron Diamond AIDS Research Center, New York University School of; Medicine, New York 10016, USA.; Close sequence homology between strains of HIV-1 have been used to corroborate cases of epidemiologically identified transmission. As an alternative to extensive DNA sequence analysis, genetic relateness between pairs of HIV quasispecies was estimated using the reduced electrophoretic mobilities of HIV-1 envelope DNA
Functional activities of 20 human immunodeficiency virus type 1 (HIV-1)-specific human monoclonal antibodies.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1095-9. Unique Identifier : AIDSLINE MED/96089216; Forthal DN; Landucci G; Gorny MK; Zolla-Pazner S; Robinson WE Jr; Department of Medicine, University of California, Irvine College; of Medicine, Orange 92668, USA.; Antibodies that are useful in the treatment of HIV infection should result in virus neutralization or lysis of infected cells but should not enhance infection. In this study, the potential clinical use of 20 HIV-1-specific human monoclonal antibodies (HuMAbs) was determined by measuring their enhancing (C-ADE) activit
Alanine substitution of two arginines in amino terminus of V3 of SIV disrupts CD4 binding whereas a similar replacement of two amino acids, lysine and arginine, in the carboxyl half of V3 prevents binding of a neutralizing monoclonal antibody.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1101-5. Unique Identifier : AIDSLINE MED/96089217; Javaherian K; Zuchowski L; Clark FT; Repligen Corporation, Cambridge, Massachusetts 02139, USA.; A series of amino acid substitutions were carried out in the V3 loop of SIV gp120 to investigate their effects on binding of the envelope to CD4 and neutralizing monoclonal antibodies. Alanine replacement of two adjacent arginines at the amino terminus of V3 resulted in a molecule that bound neither sCD4 nor conformat
Involvement of gag- and env-specific cytotoxic T lymphocytes in protective immunity to feline immunodeficiency virus.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1107-13. Unique Identifier : AIDSLINE MED/96089218; Flynn JN; Beatty JA; Cannon CA; Stephens EB; Hosie MJ; Neil JC; Jarrett O; Department of Veterinary Pathology, University of Glasgow,; Bearsden, Scotland.; Definition of the immunological mechanisms involved in protective immunity against lentiviral infections is crucial to the development of an effective vaccine. The induction of gag- and env-specific cell-mediated immune responses was studied in cats following vaccination with whole inactivated feline immunodeficiency
HTLV-I activates complement leading to increased binding to complement receptor-positive cells.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1115-22. Unique Identifier : AIDSLINE MED/96089219; Saifuddin M; Landay AL; Ghassemi M; Patki C; Spear GT; Department of Immunology/Microbiology, Rush University, Chicago,; Illinois 60612, USA.; This investigation was performed to determine whether HTLV-I can activate complement, since previous studies show that complement activation by some viruses, including HIV-1, can enhance binding to, and infection of complement receptor-positive (CR+) cells. Complement treatment increased binding of HTLV-I to CR+ HPB-A
Characterization of a transcriptional attenuator within the 5' R region of the human T cell leukemia virus type 1.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1123-9. Unique Identifier : AIDSLINE MED/96089220; Montagne J; Jalinot P; Laboratoire de Biologie Moleculaire et Cellulaire, CNRS UMR49,; Ecole Normale Superieure de Lyon, France.; Several regulatory sequences have been characterized in the HTLV-I promoter. We report here identification of a sequence element downstream of the transcriptional start site within the first 52 nucleotides of the 5 R region, which acts negatively on the activity of the HTLV-I promoter. Determination of the half-lives
Does the key to a successful HIV type 1 vaccine lie among the envelope sequences of infected individuals?: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1131-3. Unique Identifier : AIDSLINE +; Rencher SD; Slobod KS; Dawson DH; Lockey TD; Hurwitz JL; Department of Immunology, St. Jude Children's Research Hospital,; Memphis, Tennessee, USA.
Analysis of the V3 loop sequences from 10 HIV type 1-infected AIDS patients from Paraguay.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1135-7. Unique Identifier : AIDSLINE MED/96089222; Cabello A; Cabral M; Vera ME; Kiefer R; Azorero RM; Eberle J; Gurtler L; Von Brunn A; Instituto de Investigaciones en Ciencias de la Salud, Universidad; Nacional de Asuncion, Paraguay.
Highly divergent env sequences of HIV-1 B subtype with two novel V3 loop motifs detected in an AIDS patient in Miami, Florida.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1139-41. Unique Identifier : AIDSLINE MED/96089223; Xin KQ; Shapshak P; Kawamoto S; Nagano I; McCoy CB; Okuda K; Department of Psychiatry, University of Miami Medical School,; Florida 33136, USA.
Sequence and phylogenetic analysis of glycoprotein 120 of an HIV type 1 variant (GWGR) prevalent in Brazil.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1143-5. Unique Identifier : AIDSLINE MED/96089224; da Costa SM; Schechter M; Shindo N; Vicente AC; Oliveira EF; Pinto ME; Tanuri A; Departamento de Genetica, Universidade Federal do Rio de; Janeiro, Brazil.
Molecular characterization of an HIV type 1 isolate from Burundi.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1146. Unique Identifier : AIDSLINE MED/96089225; Ranjbar
Apparent bypass of negative selection in CD8+ tumours in CD2-myc transgenic mice.: Br J Cancer. 1996 Jan;73(1):13-7. Unique Identifier : AIDSLINE MED/96146594; Cameron ER; Campbell M; Blyth K; Argyle SA; Keanie L; Neil JC; Onions DE; Department of Veterinary Pathology, University of Glasgow; Veterinary School, UK.; A role for antigen stimulation in lymphoid neoplasia has been postulated and is supported by indirect evidence that suggests that the interaction of antigen with both T cells and B cells may constitute an epigenetic event that can contribute to tumour induction or tumour progression. Using myc-bearing transgenic mice
Outreach work in HIV prevention effective [news]: Nurs Stand. 1995 Nov 22-28;10(9):14. Unique Identifier : AIDSLINE MED/96153242; Blakey V; Franklan J
Efficacy of ultraviolet B phototherapy for psoriasis in patients infected with human immunodeficiency virus.: Photodermatol Photoimmunol Photomed. 1995 Jun;11(3):107-11. Unique Identifier : AIDSLINE MED/96139930; Fotiades J; Lim HW; Jiang SB; Soter NA; Sanchez M; Moy J; Ronald O. Perelman Department of Dermatology, New York University; School of Medicine, NY 10016, USA.; To evaluate the efficacy of ultraviolet B (UVB) phototherapy for the treatment of psoriasis in patients infected with human immunodeficiency virus (HIV), the response of 14 patients was compared to that of matched seronegative control individuals. All patients were evaluated prior to treatment (baseline) and after 21
HIV disease and Malassezia yeasts: a quantitative study of patients presenting with seborrhoeic dermatitis.: Br J Dermatol. 1995 Nov;133(5):694-8. Unique Identifier : AIDSLINE MED/96142527; Schechtman RC; Midgley G; Hay RJ; Medical Mycology Department, St John's Institute of Dermatology,; St Thomas' Hospital, London, U.K.; Seborrhoeic dermatitis (SD) is a disease that affects 1-3% of the general population, 3-5% of young adults and 20-83% of patients with AIDS. Malassezia yeasts have been associated with the pathogenesis of this condition. The association between the Malassezia yeasts and HIV-related SD is still a controversial subject.
Pityriasis rubra pilaris and HIV infection: a part of the spectrum of HIV-associated follicular syndrome [letter]: Br J Dermatol. 1995 Nov;133(5):818-9. Unique Identifier : AIDSLINE MED/96142556; Sanchez-Regana M; Fuentes CG; Creus L; Salleras M; Umbert P
Autoimmune mechanisms of depletion of CD4 cells in HIV infection.: Br J Haematol. 1995 Nov;91(3):525-34. Unique Identifier : AIDSLINE MED/96048888; Dalgleish AG; Division of Oncology, St George's Hospital Medical School,; London.
Decreased potency of MDR-modulators under serum conditions determined by a functional assay.: Br J Haematol. 1995 Nov;91(3):652-7. Unique Identifier : AIDSLINE MED/96048907; Ludescher C; Eisterer W; Hilbe W; Hofmann J; Thaler J; Department of Internal Medicine, University of Innsbruck,; Austria.; A variety of agents are capable of overcoming P-glycoprotein-mediated multidrug resistance (MDR) in vitro. However, the clinical potential of these compounds is often limited due to high plasma protein binding. We compared the efficacy of several MDR-reversing compounds in serum-free culture medium and under serum con
Persistent hepatitis C virus RNA replication in haemophiliacs: role of co-infection with human immunodeficiency virus.: Br J Haematol. 1995 Nov;91(3):703-7. Unique Identifier : AIDSLINE MED/96048917; Chambost H; Gerolami V; Halfon P; Thuret I; Michel G; Sicardi F; Rousseau S; Perrimond H; Cartouzou G; Service d'Hematologie Pediatrique, CHU Timone, Marseille,; France.; In order to evaluate the evolution of transfusional hepatitis C in haemophiliacs, we performed a retrospective study of ALT levels and HCV viraemia with a RNA PCR assay in 57 patients. We found that the vast majority of HCV-infected patients remained viraemic (43/57 = 75%) and higher ALT levels correlated with HCV vir
Hepatitis C virus genotypes and severity of chronic liver disease in haemophiliacs.: Br J Haematol. 1995 Nov;91(3):708-13. Unique Identifier : AIDSLINE MED/96048918; Tagariello G; Pontisso P; Davoli PG; Ruvoletto MG; Traldi A; Alberti A; Centre for Blood Diseases, Castelfranco Veneto Hospital, TV,; Italy.; We studied the activity and stage of chronic liver disease in 45 HCV-seropositive/HIV-seronegative patients with severe haemophilia followed for at least 10 years. HCV-RNA was detected in serum in 36 patients (80%) Viraemic cases were further analysed for HCV genotypes: 10 (28%) were infected by type 1a, 10 (28%) by t
Effect of human immunodeficiency virus type 1 (HIV-1) nucleocapsid protein on HIV-1 reverse transcriptase activity in vitro.: Biochemistry. 1996 Jan 9;35(1):132-43. Unique Identifier : AIDSLINE MED/96134828; Ji X; Klarmann GJ; Preston BD; Department of Biochemistry, University of Utah, Salt Lake City; 84112, USA.; Conversion of human immunodeficiency virus type 1 (HIV-1) genomic RNA to viral DNA is a requisite step in the virus life cycle. This conversion is catalyzed by reverse transcriptase (RT) associated with a large nucleoprotein complex composed of several viral proteins including nucleocapsid (NC). To better characterize
Extension of the polarity-dependent switch phenomenon of the gp120 binding domain as a target for antiviral chemotherapy.: Biochemistry. 1996 Jan 16;35(2):411-7. Unique Identifier : AIDSLINE MED/96140213; Graf von Stosch A; Kinzel V; Reed J; Department of Pathochemistry, German Cancer Research Center,; Heidelberg, Germany.; A 15-residue fragment within the major continuous domain of gp120 from HIV-1 that can bind independently to the CD4 receptor has been shown to have the property of behaving as a solvent polarity-dependent conformational switch. The switch behavior (cooperative transition from beta-sheet to helical conformation as a fu
Public policy statement on primary medical care for HIV infected patients in addiction treatment.: J Addict Dis. 1995;14(3):129-30. Unique Identifier : AIDSLINE MED/96127017
Public policy statement on HIV testing of patients in addiction treatment facilities.: J Addict Dis. 1995;14(3):131-3. Unique Identifier : AIDSLINE MED/96127018
Seroprevalence and risk factors associated with HTLV-I/II infection in injection drug users in northern New Jersey.: J Addict Dis. 1995;14(3):51-66. Unique Identifier : AIDSLINE MED/96127013; Freeman RC; Rodriguez GM; French JF; New Jersey State Department of Health, Division of Alcoholism,; Drug Abuse, and Addiction Services, Newark, USA.; Data from an AIDS Demonstration Research project in Paterson, NJ, that enrolled out-of-treatment injection drug users (IDUs) were analyzed to detect demographic patterns and risk factors associated with infection with human immunodeficiency virus (HIV) and human T-lymphotropic virus types I or II (HTLV-I/II). Of 410 I
[Pneumocystis carinii infection in AIDS patients. Current prognosis of the respiratory insufficiency (editorial)]: Enferm Infecc Microbiol Clin. 1995 Oct;13(8):447-9. Unique Identifier : AIDSLINE MED/96079579; Rello J; Villagra A; Cervantes M
[Didanosine]: Enferm Infecc Microbiol Clin. 1995 Oct;13(8):487-90. Unique Identifier : AIDSLINE MED/96079589
[Attempted suicide using massive doses of zidovudine (letter)]: Enferm Infecc Microbiol Clin. 1995 Oct;13(8):494-5. Unique Identifier : AIDSLINE MED/96079592; Perez-Molina JA; Canas P; Casado JL
[Epidemiology of a hospital outbreak of scabies (letter)]: Enferm Infecc Microbiol Clin. 1995 Oct;13(8):495-6. Unique Identifier : AIDSLINE MED/96079593; Ortega L; Sierra M; Cid R; Rodriguez T; Aparicio M
[Ulcer in the urethral meatus and HIV infection (letter)]: Enferm Infecc Microbiol Clin. 1995 Oct;13(8):497-8. Unique Identifier : AIDSLINE MED/96079596; Len O; de Otero J; Ribera E; Ocana I
Infective complications after minor operations in patients infected with HIV: role of CD4 lymphocytes in prognosis.: Eur J Surg. 1995 Oct;161(10):721-3. Unique Identifier : AIDSLINE MED/96136956; Emparan C; Iturburu IM; Portugal V; Apecechea A; Bilbao JE; Mendez JJ; Department of Surgery, Universidad del Pais Vasco, General; Surgery B, Hospital de Basurto, Bilbao, Spain.; OBJECTIVE: To find out the incidence of wound infection in patients with HIV and reduced counts of CD4 lymphocytes. DESIGN: Open study. SETTING: University hospital, Spain . SUBJECTS: 70 patients with HIV infection and enlarged lymph nodes. INTERVENTIONS: Biopsy of lymph nodes and wi
[Fusion of negatively-charged liposomes under the effect of peptides from the N-terminal fragment of the HIV-1 transmembrane protein]: Biokhimiia. 1995 Oct;60(10):1711-9. Unique Identifier : AIDSLINE MED/96098219; Terletskaia IaT; Trikash IO; Serdiuk ES; Andreev SM; The effect of a series of synthetic peptides mimicking the N-terminus of HIV transmembrane glycoprotein (gp41) on fusion of negatively charged liposomes consisting of phosphatidylcholine, phosphatidylethanolamine and cardiolipin at a 2:3:5 molar ratio, respectively, has been studied. Peptides P514 and P385 (residue 51
Complete remission in severe aplastic anemia after high-dose cyclophosphamide without bone marrow transplantation.: Blood. 1996 Jan 15;87(2):491-4. Unique Identifier : AIDSLINE MED/96141068; Brodsky RA; Sensenbrenner LL; Jones RJ; Johns Hopkins Oncology Center, Johns Hopkins Medical; Institutions, Baltimore, MD 21287-8967, USA.; Severe aplastic anemia (SAA) can be successfully treated with allogeneic bone marrow transplantation (BMT) or immunosuppressive therapy. However, the majority of patients with SAA are not eligible for BMT because they lack an HLA-identical sibling. Conventional immunosuppressive therapy also has major limitations; man
Persistent activation of the tumor necrosis factor system in a subgroup of patients with common variable immunodeficiency--possible immunologic and clinical consequences.: Blood. 1996 Jan 15;87(2):674-81. Unique Identifier : AIDSLINE MED/96141088; Aukrust P; Lien E; Kristoffersen AK; Muller F; Haug CJ; Espevik T; Froland SS; Medical Department A, National Hospital, University of Oslo,; Norway.; In patients with common variable immunodeficiency (CVI), we have previously defined a subgroup of patients (CVIHyper) characterized by decreased numbers of CD4+ lymphocytes in peripheral blood, splenomegaly, and persistent immune activation in vivo, particularly of monocytes/macrophages. To further characterize this h
Hepatitis C virus RNA in patients with anti-HCV on hemodialysis. Relationship to transaminase levels.: ASAIO J. 1994 Jul-Sep;40(3):M450-3. Unique Identifier : AIDSLINE MED/96145400; Garcia-Valdecasas J; Bernal C; Cerezo S; Garcia F; Montiel N; Leyva A; Umana WO; Bosch JP; Department of Medicine, Hospital Universitario, University of; Granada, Spain.; This study was performed in patients with hepatitis C virus (HCV) who were treated with hemodialysis to determine the relationships among alanine amino-transferase (ALT) levels, immunoglobulin (Ig) G anti-HCV, IgM anti-HCV core, and HCV RNA. Of 107 patients on hemodialysis, 27 had positive IgG anti-HCV. Eight of the p
Cell cycle inhibition of HTLV-I transformed T cell lines by retinoic acid: the possible therapeutic use of thioredoxin reductase inhibitors.: Oncol Res. 1995;7(3-4):183-9. Unique Identifier : AIDSLINE MED/96170919; U-Taniguchi Y; Furuke K; Masutani H; Nakamura H; Yodoi J; Institute for Virus Research, Kyoto University, Japan.; Adult T cell leukemia derived factor (ADF), which was first reported as a cytokine-like factor produced by human T lymphotropic virus I (HTLV-I)-transformed T cells, is a human homologue of thioredoxin (TRX). ADF/TRX has multiple functions including growth promoting, antiapoptotic and radical scavenging activities, an
Ovine lentivirus infection: an animal model for pediatric HIV infection?: Arch Med Res. 1995 Winter;26(4):345-54. Unique Identifier : AIDSLINE MED/96107853; de la Concha-Bermejillo A; Juste RA; Kretschmer R; Aguilar Setien A; Department of Pathology, Texas A & M University Agricultural; Experiment Station, San Angelo, USA.; While the incidence of the human immunodeficiency virus (HIV) infection has leveled off somewhat in homosexual men, infection in women, children and adolescents is rising. Unless effective preventive measures are introduced, the number of pediatric patients with HIV and related illnesses will continue to increase. Ani
Clinical neurophysiological comparative study on HTLV-1 associated myelopathy/tropical spastic paraparesis.: Arch Med Res. 1995 Winter;26(4):397-403. Unique Identifier : AIDSLINE MED/96107859; Leon FE; Arimura K; Arimura Y; Sonoda Y; Suwazono S; Osame M; Third Department of Internal Medicine, Kagoshima University; School of Medicine, Japan.; In order to determine the neurophysiological characteristics of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) throughout the world, we analyzed and compared the most common clinical neurophysiological studies (CNPS) performed in this entity from those places with a high prevalence and interesting
[The seroprevalence of human immunodeficiency virus infection (HIV) in patients with tuberculosis at the National Hospital of Niamey, Niger (1990-1991)]: Bull Soc Pathol Exot. 1995;88(3):121-3. Unique Identifier : AIDSLINE MED/96150686; Ousseini H; Kim DS; Adamou A; Faculte des Sciences de la Sante, Niamey, Niger.; This study has been planned in order to determinate the frequency of the infection by VIH among the 394 new tuberculous, for a period extended from July 1990 to July 1991 at the section of pneumophtisiology in the National Hospital of Niamey. The number of seropositives is 7.6%. The two types of viruses, i.e. VIH1 and
[The seroprevalence of human immunodeficiency virus infection (HIV) in the Touaregs and Peuls Bororo in Niger]: Bull Soc Pathol Exot. 1995;88(3):124-5. Unique Identifier : AIDSLINE MED/96150687; Ousseini H; Meynard D; Soumana Adamou H; Faculte des Sciences de la Sante, Niamey, Niger.; A seroepidemiological study of endemic treponematosis (bejel) in Niger allows us to realise an anonymous non correlated screening of VIH infection in Nomads: Touaregs of Tchirozerine (Agadez), Peuls Boro of Bermo (Maradi). On the 424 Touaregs screened only one was seropositive to VI
[Seroprevalence of rickettsial infections of the Boutonneuse fever group or its apparent group in Bangui (Central African Republic)]: Bull Soc Pathol Exot. 1995;88(3):126-8. Unique Identifier : AIDSLINE MED/96150688; Ekala MT; Gresenguet G; Belec L; Laboratoire de Virologie, Hopital Broussais, Paris, France.; 115 sera from African individuals, including 66 HIV-1-infected individuals and 49 HIV-seronegative age-matched healthy controls, living in Bangui, Central African Republic , were screened for Rickettsia conorii antibody by indirect immunofluorescent assay; 53 (46%) s
[Intra-family transmission of human T-cell lymphotropic virus-1 (HTLV-1) in a cohort of HTLV-1-positive patients (Benin)]: Bull Soc Pathol Exot. 1995;88(3):79-80. Unique Identifier : AIDSLINE MED/96150674; Houinato D; Verdier M; Josse R; Foundohou J; Preux PM; Avode G; Zohoun T; Denis F; Dumas M; Institut d'Epidemiologie neurologique et de neurologie; tropicale, Limoges.; We are reporting the results of a familial study carried out in Benin in March 1994 within a cohort of HTLV-1 positive subjects. This study aims at appraising the different modes of intra-familial transmission of this retrovirus. The study has included 212 persons: 33 seropositive s
[Pulmonary abscess in Lome. Apropos of 144 cases collected in the Pneumo-Phthisiology Department of the University Hospital Center-Tokoin from 1981-1993]: Bull Soc Pathol Exot. 1995;88(3):95-6. Unique Identifier : AIDSLINE MED/96150678; Tidjani O; Gbadoe AH; Grunitzky-Bekele M; Adjadja K; Lawson-Apetoh A; Djinadou G; Service de Pneumo-phtisiologie et des Maladies Infectieuses,; CHU-Tokoin, Lome, Togo.; The authors report the results of a retrospective study of 144 cases of lung abscess observed in the Pneumo-Phthisiology Department of Tokoin University Teaching Hospital of Lome ( Togo ) between 1981 and 1993 for to determine epidemiological, clinical, therapeutical and evolutive aspe
Science throws light on HIV suppression [news]: BMJ. 1995 Dec 16;311(7020):1591. Unique Identifier : AIDSLINE MED/96111851; Boulton A
Notification of tuberculosis is compatible with venereal diseases regulations [letter]: BMJ. 1995 Dec 16;311(7020):1642. Unique Identifier : AIDSLINE MED/96111886; Metters JS
Incidence of HIV infection decreases because of nature of epidemics [letter]: BMJ. 1996 Jan 13;312(7023):125. Unique Identifier : AIDSLINE MED/96141956; Brody S
HIV prevalence and risk behaviour among intravenous drug users attending HIV counselling and testing centres in Paris.: Addiction. 1995 Dec;90(12):1627-33. Unique Identifier : AIDSLINE MED/96127656; Helal H; Momas I; Pretet S; Marsal L; Poinsard R; Centre d'information et de depistage anonyme et gratuit du VIH,; Paris, France.; This study was designed to analyse sexual and drug use behaviour, to determine whether increased awareness can lead to behaviour change, and to evaluate the association between HIV seropositivity and potential risk factors. A 4-month survey was carried out on 147 IVDUs attending three HIV counselling and testing centr
The role of needle exchanges in modifying sharing behaviour: cross-study comparisons 1989-1993.: Addiction. 1995 Dec;90(12):1635-45. Unique Identifier : AIDSLINE MED/96127657; Klee H; Morris J; Manchester Metropolitan University, Department of Psychology, UK.; In this paper the relationship between sharing behaviour and needle-exchange attendance is examined. Data from three studies of drug misuse carried out consecutively from 1989 to 1993 in the north-west of England are compared. Samples differed in their drug preferences. Analyses of sharing injecting equipment comparin
The need to preserve historical material [letter]: Addiction. 1995 Dec;90(12):1683. Unique Identifier : AIDSLINE MED/96127661; Berridge V
MHC class I-selected CD4-CD8-TCR alpha beta+ T cells: an important source of IL-4.: Braz J Med Biol Res. 1995 Aug;28(8):903-5. Unique Identifier : AIDSLINE MED/96098120; Leite-de-Moraes MC; Dy M; Universite Rene Descartes, Paris, France.; Differentiation of naive CD4+ lymphocytes into either Th1 or Th2 cells is influenced by the cytokine present during initial antigen priming. IL-4 is the critical element in the induction of Th2 response; however, its origin during a primary immune response is not well-defined. Here, a novel source of IL-4, the class I
Differences in the glycosylation of recombinant and native human milk bile salt-stimulated lipase revealed by peptide mapping.: J Chromatogr A. 1995 Dec 1;718(1):53-8. Unique Identifier : AIDSLINE MED/96129766; Stromqvist M; Lindgren K; Hansson L; Juneblad K; ASTRA HASSLE AB, Umea, Sweden.; The milk of some mammals contains a bile salt-stimulated lipase (BSSL). Human milk BSSL is heavily glycosylated (30-40% carbohydrate) and present at a concentration of approximately 100-200 mg/l, thereby being one of the most abundant human whey proteins. BSSL has been shown to have an important role in the uptake of
A randomized, double-blind, placebo-controlled, dose-ranging study of dofetilide in patients with inducible sustained ventricular tachyarrhythmias.: J Cardiovasc Electrophysiol. 1995 Sep;6(9):687-99. Unique Identifier : AIDSLINE MED/96098524; Echt DS; Lee JT; Murray KT; Vorperian V; Borganelli SM; Crawford DM; Friedrich T; Roden DM; Department of Medicine, Vanderbilt University School of Medicine,; Nashville, Tennessee, USA.; INTRODUCTION: Dofetilide is a new antiarrhythmic agent with potent IK blocking properties in vitro. We developed a dose-ranging, placebo-controlled study design to define the range of effective doses and to evaluate the clinical electrophysiology of intravenous dofetilide in patients in whom sustained ventricular tach
Selective effects of DNA damaging agents on HIV long terminal repeat activation and virus replication in vitro.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):109-16. Unique Identifier : AIDSLINE MED/96147310; Manome Y; Yao XJ; Kufe DW; Cohen EA; Fine HA; Division of Cancer Pharmacology, Dana Farber Cancer Institute,; Harvard Medical School, Boston, Massachusetts 02115, USA.; Much attention has recently focused on the observation that UV light can activate the long terminal repeat (LTR) of the human immunodeficiency virus (HIV). Although the mechanism of LTR activation remains obscure, several lines of investigation have suggested that it is a result of activation of the NF-kappa B transcr
Zidovudine kinetics in the pregnant baboon.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):117-27. Unique Identifier : AIDSLINE MED/96147311; Garland M; Szeto HH; Daniel SS; Tropper PJ; Myers MM; Stark RI; College of Physicians and Surgeons, Columbia University, New; York, NY 10032, USA.; The devastating impact of human immunodeficiency virus (HIV) infection during pregnancy has made the pharmacologic evaluation of potentially therapeutic agents of high priority. The results presented here are the maternal pharmacokinetics from a series of experiments to delineate more clearly the complex maternal-feta
CD4+ T-lymphocyte lines developed from HIV-1-seropositive patients recognize different epitopes within the V3 loop.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):128-36. Unique Identifier : AIDSLINE MED/96147312; Ratto S; Sitz KV; Scherer AM; Loomis LD; Cox JH; Redfield RR; Birx DL; Henry M. Jackson Foundation, Rockville, MD 20850, USA.; To define the epitopes present within the V3 loop sequence recognized by five HIV-1 envelope-specific T-cell lines, a panel of V3 LAI peptides bearing sequential truncations from both the N- and C-terminus was synthesized and tested for their ability to induce proliferation. Each individual T-cell line had a different
L-cycloserine, an inhibitor of sphingolipid biosynthesis, inhibits HIV-1 cytopathic effects, replication, and infectivity.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):137-41. Unique Identifier : AIDSLINE MED/96147313; Mizrachi Y; Lev M; Harish Z; Sundaram SK; Rubinstein A; Department of Pediatrics, Microbiology and Immunology, Albert; Einstein College of Medicine, Bronx, NY 10461, USA.; Drugs that reduce viral production or prevent viral spread by interference with the host s cellular components are unlikely to induce resistance, in contrast to treatment modalities that interact with the HIV-1 life cycle. Two features make L-cycloserine (L-CS) a candidate drug of this kind: (a) L-CS is a potent inhib
Long-term follow-up of symptomatic HIV-infected patients originally randomized to early versus later zidovudine treatment; report of a Veterans Affairs Cooperative Study. VA Cooperative Study Group on AIDS Treatment.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):142-50. Unique Identifier : AIDSLINE MED/96147314; Simberkoff MS; Hartigan PM; Hamilton JD; Day PL; Diamond GR; Dickinson GM; Drusano GL; Egorin MJ; George WL; Gordin FM; Hawkes CA; Jensen PC; Kilmas NG; Labriola AM; O'Brien WA; Oster CN; Weinhold KJ; Wray NP; Pazner SB; Department of Veterans Affairs Medical Centers, New York, New; York, Baltimore, Maryland, USA.; Following a 4-year controlled trial comparing early and later zidovudine treatment, we conducted an additional 3-year follow-up. Of the original 338 patients, 275 participated. Clinical outcome measures were AIDS and death. In the early therapy group (n = 170), 67 patients progressed to AIDS compared with 85 in the la
Decisions to get HIV tested and to accept antiretroviral therapies among gay/bisexual men: implications for secondary prevention efforts.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):151-60. Unique Identifier : AIDSLINE MED/96147315; Stall R; Hoff C; Coates TJ; Paul J; Phillips KA; Ekstrand M; Kegeles S; Catania J; Daigle D; Diaz R; Center for AIDS Prevention Studies, University of California, San; Francisco 94143, USA.; The objective of this study was to report prevalence rates of adherence by HIV-seropositive individuals to medical recommendations for the treatment of HIV infection, a behavioral pattern referred to as AIDS secondary prevention. We report cross-sectional data (n = 2,593) from two household-based and two bar-based sam
Response of CD4 lymphocytes and clinical consequences of treatment using ddI or ddC in patients with advanced HIV infection.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):161-9. Unique Identifier : AIDSLINE MED/96147316; Goldman AI; Carlin BP; Crane LR; Launer C; Korvick JA; Deyton L; Abrams DI; Division of Biostatistics, School of Public Health, University of; Minnesota, Minneapolis 55455-0392, USA.; The value of CD4 lymphocyte counts as a surrogate marker in persons with advanced human immunodeficiency virus infection during antiretroviral treatment was assessed using longitudinal models and data from the Terry Beirn Community Programs for Clinical Research on AIDS didanosine/zalcitabine trial of 467 HIV-infected
Liver biopsy findings in 501 patients infected with human immunodeficiency virus (HIV).: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):170-7. Unique Identifier : AIDSLINE MED/96147317; Poles MA; Dieterich DT; Schwarz ED; Weinshel EH; Lew EA; Lew R; Scholes JV; New York University Medical Center, NY 10016, USA.; Patients infected with human immunodeficiency virus (HIV) are at risk for a variety of liver diseases. We undertook a retrospective study of 501 HIV-seropositive patients to assess the yield of percutaneous liver biopsy. The most common indications for liver biopsy were liver test abnormalities (89.5%), fever for 2 we
Marital status in relation to Kaposi's sarcoma, non-Hodgkin's lymphoma, and anal cancer in the pre-AIDS era.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):178-82. Unique Identifier : AIDSLINE MED/96147318; Biggar RJ; Melbye M; Viral Epidemiology Branch, National Cancer Institute, Bethesda,; Maryland, USA.; Persons with human immunodeficiency virus/AIDS are at high risk of Kaposi s sarcoma (KS), non-Hodgkin lymphoma (NHL), and possibly anal cancers. To examine whether this risk preceded the AIDS epidemic, we used pre-AIDS era data from the Surveillance, Epidemiology, and End Results program (excluding Connecticut) from 1
High rates of sexual contact with female sex workers, sexually transmitted diseases, and condom neglect among HIV-infected and uninfected men with tuberculosis in Abidjan, Cote d'Ivoire.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):183-7. Unique Identifier : AIDSLINE MED/96147319; Sassan-Morokro M; Greenberg AE; Coulibaly IM; Coulibaly D; Sidibe K; Ackah A; Tossou O; Gnaore E; Wiktor SZ; De Cock KM; Project RETRO-CI, Abidjan, Cote d'Ivoire.; To characterize human immunodeficiency virus (HIV) risk practices among men with tuberculosis, and to determine what factors are associated with HIV infection in this population, we conducted a case-control analysis of data collected during enrollment in a prospective cohort study in the two large tuberculosis treatme
Changes in membrane enzymes and glycosphingolipids in lymphocytes from HIV-1--infected and noninfected intravenous drug users.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):188-97. Unique Identifier : AIDSLINE MED/96147320; Leoni LM; Losa GA; Laboratory of Cellular Pathology, Institute of Pathology,; Locarno, Switzerland.; The amounts of cell-surface glycosphingolipids and plasma membrane enzymes produced on the peripheral blood mononuclear cells (PBMNCs) isolated from 101 intravenous drug users (IDUs), of whom 91 were HIV-1 seropositive, were examined. Seronegative IDUs and age-matched healthy donors served as controls. The numbers of
Psychological dysfunction and HIV/AIDS risk behavior.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):198-202. Unique Identifier : AIDSLINE MED/96147321; Camacho LM; Brown BS; Simpson DD; Institute of Behavioral Research, Texas Christian University,; Forth Worth 76129, USA.; The relationship between psychological problems and human immunodeficiency virus HIV/AIDS risk-taking behaviors was examined among 834 daily opioid users entering methadone treatment programs. A composite measure of psychological dysfunction was created using depression, anxiety, and hostility scales. This measure was
Role of primary infection in epidemics of HIV in gay cohorts [letter; comment]: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):204. Unique Identifier : AIDSLINE MED/96147323; Ahlgren DJ
p24 antigenemia in African patients during primary HIV infection [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):204-5. Unique Identifier : AIDSLINE MED/96147324; Simon F; Descamps D; Boucheaud O; Lacassin F; Bedos JP; Dussaix E; Brun-Vezinet F
Using HIV/AIDS surveillance to monitor public health efforts to reduce perinatal transmission of HIV [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):205-6. Unique Identifier : AIDSLINE MED/96147325; Wortley PM; Fleming PL; Lindegren ML; Sweeney PA; Davis S
14-year follow-up of HIV-infected homosexual men with lymphadenopathy syndrome [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):206-8. Unique Identifier : AIDSLINE MED/96147326; Kaplan JE; Spira TJ; Fishbein DB; Lyn HS
HIV seroprevalence study among 729 female prostitutes in Italy [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):208-9. Unique Identifier : AIDSLINE MED/96147327; Tirelli U; Spina M; Mancuso S; Traina C; Sinicco A
[Withdrawal in opiate addicts in an internal medicine hospital unit]: Bull Acad Natl Med. 1995 Oct;179(7):1335-51; discussion 1351-4. Unique Identifier : AIDSLINE MED/96151625; Cremer GA; Boissonnas A; Service de Medecine Interne, Groupe hospitalier Cochin, Paris.; Withdrawal of opiates drug addicts in Internal Medicine is unusual in France . Four main preliminary conditions are requested: 1--Drug addict preparation and self motivation, 2--Inter and intra institution team collaboration, 3--Opening the hospital towards community agencies, 4--Ho
Markers of hepatitis C and B virus infections among blood donors in Ho Chi Minh City and Hanoi, Vietnam.: Clin Diagn Lab Immunol. 1994 Jul;1(4):413-8. Unique Identifier : AIDSLINE MED/96050848; Song P; Duc DD; Hien B; Nakata S; Chosa T; Watanabe J; Tsuda F; Murata K; Okamoto H; Institute for Clinical Research in Tropical Medicine, Bach Mai; Hospital, Hanoi, Vietnam.; Blood donors in two cities in Vietnam were tested for markers of hepatitis C virus (HCV) and hepatitis B virus infections. Antibody to HCV was detected by passive hemagglutination with antigens of the second generation in 101 (20.6%) of 491 donors in Ho Chi Minh City; it was detec
Antineurofilament and antiretinal antibodies in AIDS patients with cytomegalovirus retinitis.: Clin Diagn Lab Immunol. 1994 Jul;1(4):445-9. Unique Identifier : AIDSLINE MED/96050853; Rosberger DF; Tshering SL; Polsky B; Heinemann MH; Klein RF; Cunningham-Rundles S; Department of Ophthalmology, Cornell University Medical College,; New York, New York 10021, USA.; Sera obtained from AIDS patients with cytomegalovirus ( CMV ) retinitis before and after treatment with foscarnet, AIDS patients with human immunodeficiency virus (HIV) retinopathy, AIDS patients without retinal disease, and no
Inhibitory effect of 3'-azido-3'-deoxythymidine on proliferative responsiveness of CD8+ lymphocytes to interleukin-2.: Clin Diagn Lab Immunol. 1994 Jul;1(4):482-5. Unique Identifier : AIDSLINE MED/96050859; Mercure L; Lalonde R; Phaneuf D; Brenner B; Wainberg MA; McGill University AIDS Centre, Montreal, Quebec, Canada.; Although several studies have shown that 3 -azido-3 -deoxythymidine ( AZT ) is not toxic for CD4+ lymphocytes, its effect on CD8+ cells has never been studied in a systematic way. We purified CD8+ cells from the peripheral blood mononuclear cells of bot
Monokine-mediated increase in human immunodeficiency virus type 1 expression in chronically infected promonocyte- and T-cell-derived lines.: Clin Diagn Lab Immunol. 1994 Sep;1(5):517-25. Unique Identifier : AIDSLINE MED/96050865; Ho WZ; Tomassini N; Cherukuri R; Shun-D G; Song L; Lee HR; Douglas SD; Department of Pediatrics, Children's Hospital of Philadelphia,; University of Pennsylvania Medical School 19104, USA.; The ACH-2 cell clone derived from a human T-cell line and chronically infected with human immunodeficiency virus 1 (HIV-1) and the U1 cell clone derived from a human promonocyte cell line and also chronically infected with HIV-1 produce HIV-1 in a response to stimulation with monokine-enriched supernatants prepared fr
Blood monocytes from most human immunodeficiency virus type 1-infected patients do not carry proviral DNA.: Clin Diagn Lab Immunol. 1994 Sep;1(5):531-7. Unique Identifier : AIDSLINE MED/96050867; Shen Y; Rudnik J; Cassol S; Drouin J; Cameron W; Izaguirre CA; Filion LG; Department of Microbiology, University of Ottawa General; Hospital, Ontario, Canada.; In blood, the CD4+ T cells of patients with human immunodeficiency virus type 1 (HIV-1) harbor HIV-1; however, whether the CD4+ blood monocytes carry the virus is controversial. Tissue macrophages are known to be infected. To determine in blood monocytes from HIV-1-seropositive patients contain HIV-1, we separated mon
Interleukin-2-inducible natural immune (lymphokine-activated killer cell) responses as a functional correlate of progression to AIDS.: Clin Diagn Lab Immunol. 1994 Sep;1(5):538-44. Unique Identifier : AIDSLINE MED/96050868; Brenner BG; Gornitsky M; Wainberg MA; McGill AIDS Centre, Lady Davis Institute--Jewish General; Hospital, Montreal, Quebec, Canada.; The functions of natural killer (NK) cells and their interleukin-2-deducible counterparts, lymphokine-activated killer (LAK) cells, are often impaired in human immunodeficiency virus (HIV)-infected individuals. A statistical approach was used to establish if changes in LAK activity were associated with antiviral drug
Characterization of circulating CD4+ CD8+ lymphocytes in healthy individuals prompted by identification of a blood donor with a markedly elevated level of CD4+ CD8+ lymphocytes.: Clin Diagn Lab Immunol. 1994 Sep;1(5):597-605. Unique Identifier : AIDSLINE MED/96050877; Prince HE; Golding J; York J; Cellular Immunology Laboratory, American Red Cross Blood and; Tissue Services, Southern California Region, Los Angeles, USA.; During flow cytometric analysis of lymphocytes from healthy donors, we identified a donor (donor A) with 22% CD4+ CD8+ cells (versus values of
Rapid culture and quantitation of human immunodeficiency virus type 1 from patient cells without the use of mitogen-stimulated donor cells.: Clin Diagn Lab Immunol. 1994 Nov;1(6):660-6. Unique Identifier : AIDSLINE MED/96050887; Kim PK; He S; HO JL; Division of International Medicine, Cornell University Medical; College, New York, New York 10021, USA.; We report the development of a rapid, sensitive virus culture method for direct quantitation of human immunodeficiency virus (HIV) in peripheral blood mononuclear cells (PBMCs). This new method involves culturing 10(7) PBMCs from HIV-seropositive persons in 10 ml of medium containing phorbol 12-myristate 13-acetate an
Major antigenic region on the integrase (IN) protein of human immunodeficiency virus type 1 determined by reactivity of human sera and a monoclonal antibody to IN protein.: Clin Diagn Lab Immunol. 1994 Nov;1(6):678-83. Unique Identifier : AIDSLINE MED/96050890; Tachibana Y; Yasuda A; Kurata T; Oka S; Shimada K; Kojima A; Department of Pathology, National Institute of Health, Tokyo,; Japan.; The gene encoding the integrase (IN) protein of human immunodeficiency virus type 1 (HIV-1) was expressed in vaccinia virus and Escherichia coli, and sera from 55 HIV-1-infected individuals were examined for immunoreactivity to the recombinant IN proteins by Western immunoblot. Approximately 98% (54 of 55) of the HIV-
The prevalence of HIV-1 infection among inmates in Ontario, Canada.: Can J Public Health. 1995 Sep-Oct;86(5):335-9. Unique Identifier : AIDSLINE MED/96114373; Calzavara LM; Major C; Myers T; Schlossberg J; Millson M; Wallace E; Rankin J; Fearon M; HIV Social, Behavioural and Epidemiological Studies Unit, Faculty; of Medicine, University of Toronto, ON.
Neuropsychiatric HIV-1 infection study: in Kenya and Zaire cross-sectional phase I and II.: Cent Afr J Med. 1995 Oct;41(10):315-22. Unique Identifier : AIDSLINE MED/96137271; Sebit MB; Department of Psychiatry, University of Zimbabwe, Avondale,; Harare, Zimbabwe.; The objective of the study was to determine the prevalence and natural history of human immunodeficiency virus type 1 (HIV-1) associated psychiatric, neuropsychological and neurological abnormalities. A total of 408 subjects were recruited in Nairobi and Kinshasa. The study consisted of a cross sectional phase and a l
Kaposi's sarcoma in a two week old infant born to a mother with Kaposi's sarcoma/AIDS.: Cent Afr J Med. 1995 Oct;41(10):330-1. Unique Identifier : AIDSLINE MED/96137275; McCarty KA; Bungu Z; Chidamoyo Christian Hospital, Karoi, Zimbabwe.
Measurement of apoptotic cells in peripheral blood.: Cytometry. 1995 Sep 15;22(3):161-7. Unique Identifier : AIDSLINE MED/96106598; Carbonari M; Cibati M; Fiorilli M; Department of Clinical Medicine, University of Rome La Sapienza,; Italy.; The measurement of apoptosis in peripheral blood might represent a useful tool in acquired immunodeficiency syndrome (AIDS) and cancer research. Among the many assays that are currently used to identify apoptotic leukocytes, flow cytometric methods are the most valuable in terms of rapidity, simplicity, and level of a
Standardization of absolute CD4+ lymphocyte counts across laboratories: an evaluation of the Ortho CytoronAbsolute flow cytometry system on normal donors.: Cytometry. 1995 Sep 15;22(3):200-10. Unique Identifier : AIDSLINE MED/96106603; Connelly MC; Knight M; Giorgi JV; Kagan J; Landay AL; Parker JW; Page E; Spino C; Wilkening C; Mercolino TJ; Immunocytometry Research and Development, Ortho Diagnostic; Systems, Raritan, New Jersey 08869, USA.; The Ortho CytoronAbsolute is a flow cytometer designed to provide direct absolute counts of lymphocytes and their subsets from a single instrument. This study was designed to determine the performance of four geographically separated CytoronAbsolute instruments using 24-h-old, shipped, whole blood samples and to compa
Peripheral gamma delta T-cell populations in HIV-infected individuals with mycobacterial infection.: Cytometry. 1995 Sep 15;22(3):211-6. Unique Identifier : AIDSLINE MED/96106604; Ruiz P; Geraldino N; Department of Pathology, University of Miami School of Medicine,; Florida.; Previous studies have suggested that gamma delta T cells can be increased in HIV-1-seropositive individuals, although characterization of gamma delta T cell subtypes and correlation with clinical status of these patients have not been performed. We investigated groups of HIV-seropositive persons to determine the preva
CD43 and CD5 antibodies define four normal and neoplastic B-cell subsets: a three-color flow cytometric study.: Cytometry. 1995 Sep 15;22(3):223-31. Unique Identifier : AIDSLINE MED/96106606; Lynch EF; Jones PA; Swerdlow SH; Department of Pathology, University of Pittsburgh School of; Medicine, Pennsylvania, USA.; CD43 antibodies are best known for identifying normal and neoplastic T cells and a subset of neoplastic B cells in paraffin sections. The frequency of nonneoplastic CD43 + B cells in different reactive settings, the proportion of B-cell neoplasms with small CD43+ populations, and the relationship of CD43+ B cells was
Are there differences between laboratories that use or fail to use the CDC's guidelines to measure CD4+ and CD8+ T cells? [letter]: Cytometry. 1995 Sep 15;22(3):256-7. Unique Identifier : AIDSLINE MED/96106610; Ferbas J; Logar AJ
Patterns of injecting and sharing in a Scottish prison.: Drug Alcohol Depend. 1995 Oct;39(3):237-43. Unique Identifier : AIDSLINE MED/96127545; Shewan D; Macpherson A; Reid MM; Davies JB; Department of Psychology, Glasgow Caledonian University, UK.; Although the potential for prisons to act as the setting for HIV transmission has been recognised, there is an enduring lack of knowledge in this area. Data are presented on patterns of injecting and sharing in Edinburgh prison (Scotland), 1993-1994. There was a relatively low level of injecting in Edinburgh prison du
Inactivation of HIV-1 by chemical disinfectants: sodium hypochlorite.: Epidemiol Infect. 1995 Dec;115(3):567-79. Unique Identifier : AIDSLINE MED/96150221; Van Bueren J; Simpson RA; Salman H; Farrelly HD; Cookson BD; Laboratory of Hospital Infection, Central Public Health; Laboratory, London, UK.; The efficacy of sodium hypochlorite was assessed against human immunodeficiency virus type 1 suspended in low (8% v/v) or high (80% v/v) concentrations of serum or in a high (80%) concentration of blood. In the presence of 8% serum, 100 p.p.m. available chlorine in the disinfectant test mixture inactivated 3.75 log TC
NF-kappa B-mediated chromatin reconfiguration and transcriptional activation of the HIV-1 enhancer in vitro.: Genes Dev. 1996 Jan 1;10(1):37-49. Unique Identifier : AIDSLINE MED/96136707; Pazin MJ; Sheridan PL; Cannon K; Cao Z; Keck JG; Kadonaga JT; Jones KA; Department of Biology, University of California, San Diego; (UCSD), La Jolla 92093-0347, USA.; NF-kappa B is a potent inducible transcription factor that regulates many genes in activated T cells. In this report we examined the ability of different subunits of NF-kappa B to enhance HIV-1 transcription in vitro with chromatin templates. We find that the p65 subunit of NF-kappa B is a strong transcriptional activ
Human papillomavirus is associated with the frequent detection of warty and basaloid high-grade neoplasia of the vulva and cervical neoplasia among immunocompromised women.: Gynecol Oncol. 1996 Jan;60(1):30-4. Unique Identifier : AIDSLINE MED/96139371; Petry KU; Kochel H; Bode U; Schedel I; Niesert S; Glaubitz M; Maschek H; Kuhnle H; Department of Gynecological Oncology, University of Hannover,; Germany.; A total of 158 women who either HIV-infected or under iatrogenic immunosuppression were examined regularly during a 4-year period to evaluate if certain vulvar neoplasms and cervical neoplasia have similar associated risk factors. Patients with CIN were matched prospectively with immunocompetent controls with CIN. For
Multiple host defense defects in failure of C57BL/6 ep/ep (pale ear) mice to resolve visceral Leishmania donovani infection.: Infect Immun. 1996 Jan;64(1):161-6. Unique Identifier : AIDSLINE MED/96110929; Murray HW; Hariprashad J; McDermott DF; Stoeckle MY; Department of Medicine, Cornell University Medical College, New; York, New York 10021, USA.; Euthymic C57BL/L ep/ep (pale ear [PE]) mice halt the visceral replication of intracellular Leishmania donovani but fail to properly resolve infection. A previous study identified an isolated defect in tissue granuloma formation in these mice; CD4+ and CD8+ cell number, gamma interferon (IFN-gamma) production, and macr
Human CD4+ and CD8+ T lymphocytes are both cytotoxic to Toxoplasma gondii-infected cells.: Infect Immun. 1996 Jan;64(1):176-81. Unique Identifier : AIDSLINE MED/96110931; Montoya JG; Lowe KE; Clayberger C; Moody D; Do D; Remington JS; Talib S; Subauste CS; Department of Immunology and Infectious Diseases, Palo Alto; Medical Foundation, California 94301, USA.; Studies to determine if Toxoplasma gondii-specific human T cells lyse parasite-infected cells have yielded conflicting results. Furthermore, attempts to obtain human cytotoxic CD8+ T lymphocytes have been difficult because of the lack of a reproducible system for their generation. By using paraformaldehyde-fixed, T. g
Antigenic differences associated with genetically distinct Pneumocystis carinii from rats.: Infect Immun. 1996 Jan;64(1):290-7. Unique Identifier : AIDSLINE MED/96110946; Vasquez J; Smulian AG; Linke MJ; Cushion MT; Department of Internal Medicine, James Quillen College of; Medicine, Johnson City, Tennessee 37614-0622, USA.; Pneumocystis carinii is a family of organisms found in a wide variety of mammalian lungs. In immunocompromised hosts, the organisms are able to produce an oftentimes fatal pneumonia. The existence of distinct types of Pneumocystis populations is strongly supported by antigenic and genetic evidence. In the present stud
Complete development of Cryptosporidium parvum in bovine fallopian tube epithelial cells.: Infect Immun. 1996 Jan;64(1):349-54. Unique Identifier : AIDSLINE MED/96110955; Yang S; Healey MC; Du C; Zhang J; Department of Animal, Dairy and Veterinary Sciences, Utah State; University, Logan 84322-5600, USA.; Cryptosporidium parvum is a coccidian parasite responsible for causing protracted and life-threatening diarrheal illness in immunocompromised humans, especially patients with AIDS. The lack of medications effective in treating people suffering from cryptosporidiosis has prompted the development of in vivo and in vitro
Reconstitution of B-cell-depleted mice with B cells restores Th2-type immune responses during Plasmodium chabaudi chabaudi infection.: Infect Immun. 1996 Jan;64(1):366-70. Unique Identifier : AIDSLINE MED/96110959; Taylor-Robinson AW; Phillips RS; Wellcome Laboratories for Experimental Parasitology, University; of Glasgow, United Kingdom.; In mice depleted of B cells from birth by treatment with anti-immunoglobulin M(mu) antibodies, progression from a Th1- to a Th2-regulated immune response during primary infection with Plasmodium chabaudi chabaudi fails to occur. While Th1-type immunity limits parasitemia, in the absence of B cells, chronic low-grade i
Predicting in-hospital outcome in HIV-associated Pneumocystis carinii pneumonia.: Infection. 1995 Sep-Oct;23(5):272-7. Unique Identifier : AIDSLINE MED/96128586; Bauer T; Ewig S; Hasper E; Rockstroh JK; Luderitz B; Berufsgenossenschaftliche Kliniken Bergmannsheil, Abt. f.; Pneumologie u. Allergologie, Bochum, Germany.; Pneumocystis carinii pneumonia (PCP) in HIV-infected patients remains a life-threatening complication in the course of HIV infection. Despite effective treatment, mortality may still be as high as 10%. The identification of risk factors associated with a lethal outcome might be helpful as a guide to therapy for patien
Cerebrospinal fluid antiganglioside antibodies in patients with AIDS.: Infection. 1995 Sep-Oct;23(5):288-91. Unique Identifier : AIDSLINE MED/96128589; Sorice M; Griggi T; Circella A; Nicodemo G; Ciardi M; Mastroianni CM; Lenti L; Sorice F; Dip. Malattie Infettive e Tropicali, Universita La Sapienza,; Rome, Italy.; In this study the presence of brain antiganglioside antibodies in the cerebrospinal fluid (CSF) of patients with HIV infection was analysed. CSF samples were collected from 45 patients with AIDS and from 45 anti-HIV negative subjects, 15 of whom presented aseptic meningitis. Nineteen AIDS patients had clinically well-
First case of disseminated Mycobacterium avium infection following chemotherapy for childhood acute myeloid leukemia.: Infection. 1995 Sep-Oct;23(5):301-2. Unique Identifier : AIDSLINE MED/96128592; Claass A; Claviez A; Westphal E; Rusch-Gerdes S; Schneppenheim R; Institut fur Immunologie, Christian-Albrechts-Universitat,; Kiel, Germany.; A 14-year-old girl of Indian origin with acute myeloid leukemia (AML) is presented, who was diagnosed at the age of twelve. Antileukemic chemotherapy had to be discontinued after 6 weeks because of persistent high fever and the emergence of liver and spleen abscesses. Serologic and biopsy findings were consistent with
Bordetella bronchiseptica pneumonia in an AIDS patient: a new opportunistic infection [letter]: Infection. 1995 Sep-Oct;23(5):312-3. Unique Identifier : AIDSLINE MED/96128597; Libanore M; Rossi MR; Pantaleoni M; Bicocchi R; Carradori S; Sighinolfi L; Ghinelli F
Munchhausen's syndrome in an HIV-sero-indeterminate patient [letter]: Infection. 1995 Sep-Oct;23(5):315. Unique Identifier : AIDSLINE MED/96128599; Caron F; Young P; Villeneuve H; Mendel I; Pestel M; Gueit I; Lecomte F; Humbert G
Multicentre study for diagnostic evaluation of an assay for simultaneous detection of antibodies to HIV-1, HIV-2 and HIV-1 subtype 0 (HIV-0).: Infection. 1995 Sep-Oct;23(5):322-33. Unique Identifier : AIDSLINE MED/96128601; Bachmann P; Beyer J; Brust S; Engelhardt W; Gurtler LG; Habermehl KO; Karakassopoulos A; Michl U; Muhlbacher A; Stoffler-Meilicke M; et al; Swiss Red Cross, Central Laboratory, Bern, Switzerland.; The aim of the study was to evaluate a new ELISA for detection of HIV-1, HIV-2 and HIV-1 subtype 0 (HIV-0) antibodies. The assay format is based on the antigen sandwich principle. To enable specific detection of HIV-0 antibodies, in addition to HIV-1 and HIV-2 antigens HIV-0 antigen is used for coating the solid phase
Syringe exchange: HIV prevention, key findings, and future directions.: Int J Addict. 1995;30(12):1647-83. Unique Identifier : AIDSLINE MED/96122207; Paone D; Des Jarlais DC; Gangloff R; Milliken J; Friedman SR; Beth Israel Medical Center, Chemical Dependency Institute, New; York, NY 10003, USA.; HIV among injecting drug users (IDUs) has now been documented in over 60 countries in the world, and there are an additional 40 countries where injecting drug use has been reported including widespread epidemics in Southeast and southern Asia and in Latin America. At present HIV infection is almost always fatal, and t
The effect of human immunodeficiency virus infection on birthweight, and infant and child mortality in urban Malawi.: Int J Epidemiol. 1995 Oct;24(5):1022-9. Unique Identifier : AIDSLINE MED/96128733; Taha TE; Dallabetta GA; Canner JK; Chiphangwi JD; Liomba G; Hoover DR; Miotti PG; Department of Epidemiology, Johns Hopkins University School of; Hygiene and Public Health, Baltimore, MD 21205, USA.; BACKGROUND. Low birthweight, prematurity and intra-uterine growth retardation (IUGR) are major determinants of child survival. Therefore, it is important to assess excess mortality due to human immunodeficiency virus (HIV) infection in populations where low birthweight is common. METHODS. A prospective study was condu
Prevalence of HIV-1 infection in 18 year old men in Tuscany. The Toscana Collaborative Group.: Int J Epidemiol. 1995 Oct;24(5):1030-3. Unique Identifier : AIDSLINE MED/96128734; Mazzotta F; Di Pietro M; Balocchini E; Paci P; Galanti C; Abeni DD; Perucci CA; Divisione di Malattie Infettive, Ospedale S M Annunziata,; Firenze, Italy.; BACKGROUND. The main route of transmission of the human immunodeficiency virus type 1 (HIV-1) is sexual contact. A high proportion of young adults is exposed to this mode of transmission. Therefore it is important to assess the level of HIV-1 prevalence among 18 year olds in Italy .
Dietary determinants of a non-progressive spastic paraparesis (Konzo): a case-referent study in a high incidence area of Zaire.: Int J Epidemiol. 1995 Oct;24(5):949-56. Unique Identifier : AIDSLINE MED/96128723; Tylleskar T; Banea M; Bikangi N; Nahimana G; Persson LA; Rosling H; Department of Pediatrics, University Hospital, Uppsala, Sweden.; BACKGROUND. Konzo is an upper motor neuron disease in Africa, characterized by an abrupt onset of a permanent but non-progressive spastic paraparesis. It is named after the local designation in the first report from Zaire . Konzo has been attributed to a metabolic insult from the c
Effect of phosphodiesterase inhibition on IL-4 and IL-5 production of the murine TH2-type T cell clone D10.G4.1.: Immunopharmacology. 1995 Sep;30(3):191-8. Unique Identifier : AIDSLINE MED/96128551; Schmidt J; Hatzelmann A; Fleissner S; Heimann-Weitschat I; Lindstaedt R; Szelenyi I; ASTA Medica AG, Department of Pharmacology, Frankfurt/Main,; Germany.; The effect of various phosphodiesterase (PDE) inhibitors on anti-CD3 induced interleukin-(IL)-4 and IL-5 production of the murine T helper cell clone of type 2 phenotype D10.G4.1 (D10) has been investigated in vitro. D10 cells were incubated in the presence of drugs and anti-CD3 mAb for 16 h before measurement of cyto
Effects of isoniazid treatment on human lymphocyte proliferative response, lymphocyte subsets and natural killer cell activity.: Immunopharmacology. 1995 Sep;30(3):247-53. Unique Identifier : AIDSLINE MED/96128558; Ravn P; Linnet J; Klokker M; Pedersen BK; Department of Infectious Diseases, Rigshospitalet, Copenhagen,; Denmark.; The effect of isoniazid on proliferative response, natural killer (NK) cell activity and lymphocyte subset distribution of blood mononuclear cells (BMNC) was investigated. To evaluate the effect of treatment with isoniazid in pharmacologic concentrations, twenty healthy HIV-seronegative volunteers were randomized into
PCR in situ: aspects which reduce amplification and generate false-positive results.: Histochem J. 1995 Sep;27(9):660-9. Unique Identifier : AIDSLINE MED/96121506; Teo IA; Shaunak S; Department of Infectious Diseases, Royal Postgraduate Medical; School, London, UK.; PCR in situ promises the ability to amplify and detect very low levels of target nucleic acid in tissues. Despite considerable effort, the technique is still technically difficult and has not yet proved to be reliable or reproducible. We have now identified a number of factors which can contribute to the poor amplific
Reexamination of the paradigm of HIV risk reduction in adolescents.: J Am Osteopath Assoc. 1995 Dec;95(12):725-8. Unique Identifier : AIDSLINE MED/96148238; Earl DT; Department of Family Medicine, East Tennessee State University,; James H. Quillen College of Medicine, Johnson City, TN 37604,; USA.; Infection with the human immunodeficiency virus (HIV) in the adolescent/young adult population of the United States is a serious, growing problem. The current HIV risk-reduction strategies for adolescents have been less than effective in stemming the tide of infection. This ineffective
Eulicin inhibits human immunodeficiency virus infection and replication.: J Antibiot (Tokyo). 1995 Nov;48(11):1362-3. Unique Identifier : AIDSLINE MED/96139408; Nakamura M; Yoshida K; Yoshida M; Kunimoto S; Takeuchi T; Ohno T; Department of Microbiology, Jikei University School of Medicine,; Tokyo, Japan.
Siamycins I and II, new anti-HIV-1 peptides: II. Sequence analysis and structure determination of siamycin I.: J Antibiot (Tokyo). 1995 Dec;48(12):1515-7. Unique Identifier : AIDSLINE MED/96139438; Detlefsen DJ; Hill SE; Volk KJ; Klohr SE; Tsunakawa M; Furumai T; Lin PF; Nishio M; Kawano K; Oki T; et al; Bristol-Myers Squibb Pharmaceutical Research Institute,; Wallingford, CT 06492, USA.
Signal transduction pathway of interleukin-4 and interleukin-13 in human B cells derived from X-linked severe combined immunodeficiency patients.: J Biol Chem. 1996 Jan 12;271(2):619-22. Unique Identifier : AIDSLINE MED/96132783; Izuhara K; Heike T; Otsuka T; Yamaoka K; Mayumi M; Imamura T; Niho Y; Harada N; Department of Human Genetics, National Institute of Genetics,; Shizuoka, Japan.; Interleukin-4 (IL-4) and IL-13 are functionally similar cytokines. The functional IL-4 receptor (IL-4R) consists of the IL-4R alpha chain (IL-4R alpha) and the IL-2R gamma chain (gamma c), which is shared by the IL-2, IL-7, IL-9, and IL-15 receptors. The functional IL-13R is thought to involve the IL-4R alpha but not
Steps toward gene therapy: 1. The initial trials.: Hosp Pract (Off Ed). 1995 Nov 15;30(11):33-40. Unique Identifier : AIDSLINE MED/96110745; Blaese RM; Clinical Gene Therapy Branch, National Center for Human Genome; Research, National Institutes of Health, Bethesda, Md., USA.; Hopes for correcting the instruction tape in patients with genetic disease are being intensively explored. Initial efforts centered on monogenic immunodeficiency states, but in a pattern not wholly expected by researchers, the acquired genetic diseases of cancer and AIDS account for most ongoing clinical trials. Exper
Limited T cell receptor usage by HTLV-I tax-specific, HLA class I restricted cytotoxic T lymphocytes from patients with HTLV-I associated neurological disease.: J Neuroimmunol. 1995 Dec;63(1):47-53. Unique Identifier : AIDSLINE MED/96110770; Elovaara I; Utz U; Smith S; Jacobson S; Department of Neurology, Tampere University Hospital, Finland.; T cell receptor (TCR) V alpha and V beta chain usage of HTLV-I tax-specific, HLA class I restricted CD8+ cytotoxic T cells (CTL) was determined from lymphocytes obtained from peripheral blood of patients with HTLV-I associated neurological disease. To characterize TCR repertoire, CD8+ lymphocytes from peripheral blood
Position of the American Dietetic Association: oral health and nutrition.: J Am Diet Assoc. 1996 Feb;96(2):184-9. Unique Identifier : AIDSLINE MED/96160814
Abnormal thymocyte subset distribution and differential reduction of CD4+ and CD8+ T cell subsets during peripheral maturation in diabetes-prone BioBreeding rats.: J Immunol. 1996 Feb 1;156(3):1269-75. Unique Identifier : AIDSLINE MED/96144354; Groen H; Klatter FA; Brons NH; Mesander G; Nieuwenhuis P; Kampinga J; Department of Histology and Cell Biology, University of; Groningen, The Netherlands.; In this study we quantified CD8+ and CD4+ T cells in T lymphocytopenic BB rats as compared with control rats at given stages along the maturational pathway from immature thymocytes to mature peripheral T cells. Our results show that BB rats exhibit abnormal thymocyte subset distribution. Numbers of mature TCRhigh/CD4-
Adoptively transferred CD8+ T lymphocytes provide protection against TMEV-induced demyelinating disease in BALB/c mice.: J Immunol. 1996 Feb 1;156(3):1276-83. Unique Identifier : AIDSLINE MED/96144355; Nicholson SM; Dal Canto MC; Miller SD; Melvold RW; Department of Microbiology-Immunology, Northwestern University; Medical School, Chicago, IL 60611, USA.; On intracerebral infection with the BeAn strain of Theiler s murine encephalomyelitis virus (TMEV), certain mouse strains develop a chronic demyelinating disease similar both clinically and pathologically to human multiple sclerosis. Other strains remain resistant. We previously established that differential susceptib
Mechanisms for the transendothelial migration of HIV-1-infected monocytes into brain.: J Immunol. 1996 Feb 1;156(3):1284-95. Unique Identifier : AIDSLINE MED/96144356; Nottet HS; Persidsky Y; Sasseville VG; Nukuna AN; Bock P; Zhai QH; Sharer LR; McComb RD; Swindells S; Soderland C; Gendelman HE; Department of Pathology, Eppley Institute for Cancer and Allied; Disease, University of Nebraska Medical Center, Omaha 68198, USA.; HIV-1 penetration of the brain is a pivotal event in the neuropathogenesis of AIDS-associated dementia . The establishment of productive viral replication or up-regulation of adhesion molecule expression on brain microvascular endothelial cells (BMVEC) could permit entry of HIV into
HIV glycoprotein 120 enhances intercellular adhesion molecule-1 gene expression in glial cells. Involvement of Janus kinase/signal transducer and activator of transcription and protein kinase C signaling pathways.: J Immunol. 1996 Feb 1;156(3):1307-14. Unique Identifier : AIDSLINE MED/96144358; Shrikant P; Benos DJ; Tang LP; Benveniste EN; Department of Cell Biology, University of Alabama, Birmingham; 35294, USA.; It is well established that the two major glial cells in the central nervous system (CNS), astrocytes and microglia, are key participants in mediating the neurologic dysfunction associated with HIV infection of the CNS. In this study, we investigated the ability of the major envelope glycoprotein of HIV, glycoprotein
IL-12, as an adjuvant, promotes a T helper 1 cell, but does not suppress a T helper 2 cell recall response.: J Immunol. 1996 Feb 1;156(3):887-94. Unique Identifier : AIDSLINE MED/96144306; Bliss J; Van Cleave V; Murray K; Wiencis A; Ketchum M; Maylor R; Haire T; Resmini C; Abbas AK; Wolf SF; Genetics Institute Inc., Cambridge, MA 02140, USA.; IL-12 is a potent inducer of NK and cytolytic T cell activity, IFN-gamma production, and T cell proliferation, and is necessary for differentiation of naive T cells to the Th1 subset. We have previously shown that IL-12 promotes a primary Th1 response and suppresses a primary Th2 response in lymph nodes of mice primed
The role of BALB/c donor CD8+ lymphocytes in graft-versus-host disease in (BALB/c x A/J)F1 (CAF1) mice.: J Immunol. 1996 Feb 1;156(3):997-1005. Unique Identifier : AIDSLINE MED/96144319; Vidal S; Labrador M; Rodriguez-Sanchez JL; Gelpi C; Department of Immunology, Hospital de Sant Pau, Universitat; Autonoma de Barcelona, Avgda, Spain.; To investigate the role of donor T lymphocyte subsets in the development of chronic graft-vs-host disease (GVHD) induced in (BALB/c x A/J)F1 (CAF1) mice by injecting BALB/c lymphoid cells, we analyzed the effect that CD8+ cell removal from donor inoculum has on the manifestation of the disease. Compared with age- and
Further clinical studies of curdlan sulfate (CRDS)--an anti-HIV agent.: J Med. 1995;26(3-4):97-131. Unique Identifier : AIDSLINE MED/96098544; Gordon M; Guralnik M; Kaneko Y; Mimura T; Goodgame J; Lang W; Aji Pharma USA, Inc., Glenpointe Centre West, Teaneck, NJ 07666,; USA.; Curdlan sulfate (CRDS) is a semi-synthetic sulfated polysaccharide which inhibits the attachment of HIV to T-cells, and also has intracellular anti-HIV activity. In Phase I clinical trials, CRDS was found in 4 hr i.v. infusions, to be well tolerated up to 200 mg/70 kg and unexpectedly to produce marked, dose-related i
Essential role of NF-kappa B in transactivation of the human immunodeficiency virus long terminal repeat by the human cytomegalovirus 1E1 protein.: J Gen Virol. 1996 Jan;77 ( Pt 1):83-91. Unique Identifier : AIDSLINE MED/96145137; Kim S; Yu SS; Kim VN; Institute for Molecular Biology and Genetics, Seoul National; University, Kwan-Ak-Gu, Korea.; The 72 kDa 1E1 protein of human cytomegalovirus (HCMV) is one of a few viral regulatory proteins expressed immediately after infection of a host cell. Although it is now well-established that 1E1 is a potent transcriptional activator of the human immunodeficiency virus (HIV) long t
Comparative study of the cell tropism of feline immunodeficiency virus isolates of subtypes A, B and D classified on the basis of the env gene V3-V5 sequence.: J Gen Virol. 1996 Jan;77 ( Pt 1):93-100. Unique Identifier : AIDSLINE MED/96145138; Hohdatsu T; Hirabayashi H; Motokawa K; Koyama H; Department of Veterinary Infectious Diseases, School of; Veterinary Medicine and Animal Sciences, Kitasato University,; Aomori, Japan.; Feline immunodeficiency virus (FIV) isolates have been classified into subtypes A, B, C and D based on the env gene V3-V5 sequence. The cell tropism of seven new Japanese isolates and a Petaluma (prototype) isolate of FIV, which classified into subtypes A, B and D, for feline lymphoblastoid and feline fibroblastoid ce
Cyclosporin A does not reverse clinical resistance to paclitaxel in patients with relapsed non-Hodgkin's lymphoma.: J Clin Oncol. 1996 Jan;14(1):233-9. Unique Identifier : AIDSLINE MED/96140305; Sarris AH; Younes A; McLaughlin P; Moore D; Hagemeister F; Swan F; Rodriguez MA; Romaguera J; North L; Mansfield P; Callendar D; Mesina O; Cabanillas F; Department of Hematology, University of Texas M.D. Anderson; Cancer Center, Houston 77030, USA.; PURPOSE: Cyclosporin A has been shown to reverse paclitaxel resistance in vitro by inhibiting P-gp function. Therefore, we determined whether addition of cyclosporine to paclitaxel reversed clinical paclitaxel resistance in patients with non-Hodgkin s lymphoma (NHL). PATIENTS AND M
Necrotizing ulcerative gingivitis, periodontitis, and stomatitis: clinical staging and predisposing factors.: J Periodontol. 1995 Nov;66(11):990-8. Unique Identifier : AIDSLINE MED/96162545; Horning GM; Cohen ME; Naval Dental School, Bethesda, MD, USA.; Necrotizing ulcerative gingivitis (NUG), necrotizing ulcerative periodontitis (NUP), and necrotizing stomatitis (NS), collectively termed necrotizing gingivostomatitis (NG), represent a dramatic, but rare oral infection associated with diminished systemic resistance, including HIV infection. Over a 5-year period, 68 c
Cationized hyperimmune immunoglobulins: pharmacokinetics, toxicity evaluation and treatment of human immunodeficiency virus-infected human-peripheral blood lymphocytes-severe combined immune deficiency mice.: J Pharmacol Exp Ther. 1996 Jan;276(1):246-52. Unique Identifier : AIDSLINE MED/96135073; Pardridge WM; Kang YS; Diagne A; Zack JA; Department of Medicine, University of California at Los Angeles; School of Medicine, USA.; The in vivo pharmacokinetics and efficacy of cationized human immunoglobulins in the human-peripheral blood lymphocytes-severe combined immune deficiency mouse model were evaluated in the present studies using the severe combined immunodeficient mouse transplanted with human lymphocytes and infected with human immunod
Biological and biochemical anti-human immunodeficiency virus activity of UC 38, a new non-nucleoside reverse transcriptase inhibitor.: J Pharmacol Exp Ther. 1996 Jan;276(1):298-305. Unique Identifier : AIDSLINE MED/96135081; McMahon JB; Buckheit RW Jr; Gulakowski RJ; Currens MJ; Vistica DT; Shoemaker RH; Stinson SF; Russell JD; Bader JP; Narayanan VL; Schultz RJ; Brouwer WG; Felauer EE; Boyd MR; Laboratory of Drug Discovery Research and Development, National; Cancer Institute, Frederick, Maryland, USA.; UC 38, a simple analog of oxathiin carboxanilide, UC 84, lacking the oxathiin ring, was found to be a potent inhibitor of human immunodeficiency virus (HIV)-1-induced cell killing and HIV replication in a variety of human cell lines, as well as in human peripheral blood lymphocytes and macrophages. UC 38 was active ag
A novel, picomolar inhibitor of human immunodeficiency virus type 1 protease.: J Med Chem. 1996 Jan 19;39(2):392-7. Unique Identifier : AIDSLINE MED/96145172; Sham HL; Zhao C; Stewart KD; Betebenner DA; Lin S; Park CH; Kong XP; Rosenbrook W Jr; Herrin T; Madigan D; Vasavanonda S; Lyons N; Molla A; Saldivar A; Marsh KC; McDonald E; Wideburg NE; Denissen JF; Robins T; Kempf DJ; Plattner JJ; Norbeck DW; Pharmaceutical Products Division, Abbott Laboratories, Abbott; Park, Illinois 60064-3500.; The design, synthesis, and molecular modeling studies of a novel series of azacyclic ureas, which are inhibitors of human immunodeficiency virus type 1 (HIV-1) protease that incorporate different ligands for the S1 , S2, and S2 substrate-binding sites of HIV-1 protease are described. The synthesis of this series is h
Metal-chelating inhibitors of a zinc finger protein HIV-EP1. Remarkable potentiation of inhibitory activity by introduction of SH groups.: J Med Chem. 1996 Jan 19;39(2):503-7. Unique Identifier : AIDSLINE MED/96145184; Fujita M; Otsuka M; Sugiura Y; Institute for Chemical Research, Kyoto University, Japan.; HIV-EP1 is a C2H2 type zinc finger protein which binds to DNA kappa B site present in the long terminal repeat of HIV provirus. Previously we have reported zinc chelators having histidine--pyridine--histidine skeleton and were successful in inhibiting the DNA binding of HIV-EP1 by removing zinc from the zinc finger do
Correlation of anti-HIV potency with lipophilicity in a series of cosalane analogs having normal alkenyl and phosphodiester chains as cholestane replacements.: J Med Chem. 1996 Jan 19;39(2):508-14. Unique Identifier : AIDSLINE MED/96145185; Keyes RF; Golebiewski WM; Cushman M; Department of Medicinal Chemistry and Pharmacognosy, School of; Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA.; In order to define the role of the cholestane moiety in the anti-HIV agent cosalane, a series of cosalane analogs was synthesized in which the cholestane ring system was replaced by normal alkenyl and phosphodiester substituents having varied chain lengths and lipophilicities. The compounds containing simple alkenyl s
2-Sulfonyl-4-chloroanilino moiety: a potent pharmacophore for the anti-human immunodeficiency virus type 1 activity of pyrrolyl aryl sulfones.: J Med Chem. 1996 Jan 19;39(2):522-30. Unique Identifier : AIDSLINE MED/96145187; Artico M; Silvestri R; Massa S; Loi AG; Corrias S; Piras G; La Colla P; Dipartimento di Studi Farmaceutici, Universita di Roma, Italy.; The synthesis and the evaluation of cytotoxicity and anti-HIV-1 activity of new aryl pyrrolyl (8) and aryl indolyl (9) sulfones are reported. Preparation of above sulfones was achieved by reacting arylsulfonyl chlorides with substituted pyrroles and indoles or by condensing sulfonamides with 2,5-dimethoxytetrahydrofur
Synthesis and antiviral activity of 2'-deoxy-4'-thio purine nucleosides.: J Med Chem. 1996 Jan 19;39(2):538-42. Unique Identifier : AIDSLINE MED/96145189; Van Draanen NA; Freeman GA; Short SA; Harvey R; Jansen R; Szczech G; Koszalka GW; Division of Experimental Therapy, Burroughs Wellcome Company,; Research Triangle Park, North Carolina 27709, USA.; A series of 2 -deoxy-4 -thioribo purine nucleosides was prepared by trans-N-deoxyribosylase-catalyzed reaction of 2 -deoxy-4 -thiouridine with a variety of purine bases. This synthetic procedure is an improvement over methods previously used to prepare purine 4 -thio nucleosides. The compounds were tested against hepa
An ethical approach to HIV carriage and AIDS [letter]: J Med Ethics. 1995 Oct;21(5):311-2. Unique Identifier : AIDSLINE MED/96122513; Nores JM
Voiding dysfunction in human immunodeficiency virus infections.: J Urol. 1996 Feb;155(2):523-6. Unique Identifier : AIDSLINE MED/96134288; Kane CJ; Bolton DM; Connolly JA; Tanagho EA; Department of Urology, University of California School of; Medicine, San Francisco 94143-0738, USA.; PURPOSE: We prospectively evaluated the current spectrum of urodynamic pathology in patients infected with human immunodeficiency virus (HIV) who presented with voiding dysfunction. MATERIALS AND METHODS: We obtained a directed genitourinary and neurological history, and performed a physical examination and urodynamic
School health services.: J Sch Health. 1995 Oct;65(8):319-26. Unique Identifier : AIDSLINE MED/96130430; Small ML; Majer LS; Allensworth DD; Farquhar BK; Kann L; Pateman BC; Surveillance Research Section, Centers for Disease Control and; Prevention, Atlanta, GA 30341-3724, USA.
Alcohol-related risk factors associated with HIV infection among patients entering alcoholism treatment: implications for prevention.: J Stud Alcohol. 1995 Nov;56(6):642-53. Unique Identifier : AIDSLINE MED/96130453; Boscarino JA; Avins AL; Woods WJ; Lindan CP; Hudes ES; Clark W; Center for AIDS Prevention Studies, University of California, San; Francisco 94105, USA.; OBJECTIVE: Reports suggest that alcoholics may be at risk for HIV infection. In this article we examine several alcohol-related risk factors for HIV infection among patients entering alcoholism treatment in an AIDS epicenter. Our objective was to identify key factors for HIV prevention and screening among populations
Playing doctors: refiguring the doctor-patient relationship in Herve Guibert's AIDS novels.: Lit Med. 1995 Fall;14(2):237-49. Unique Identifier : AIDSLINE MED/96122859; Caron D
[Granulomatous pneumonitis: a clinical manifestation and atypical pathology of pneumocystosis in AIDS (letter)]: Med Clin (Barc). 1995 Dec 8;105(20):797. Unique Identifier : AIDSLINE MED/96150977; Macias J; Navarro G; Pineda JA; Lissen E
Recent development in the design of antiviral agents.: Med Res Rev. 1995 Nov;15(6):497-531. Unique Identifier : AIDSLINE MED/96130678; Saunders J; Cameron JM; Department of Medicinal Chemistry II, Glaxo Research and; Development Limited, Stevenage, Herts, UK.
TNF and AIDS: two sides of the same coin?: Med Res Rev. 1995 Nov;15(6):533-46. Unique Identifier : AIDSLINE MED/96130679; Pallares-Trujillo J; Lopez-Soriano FJ; Argiles JM; Departament de Bioquimica i Fisiologia, Facultat de Biologia,; Universitat de Barcelona, Spain.
[Relationship between chronic liver diseases and hepatitis C in Burundi adults]: Med Trop (Mars). 1995;55(3):235-7. Unique Identifier : AIDSLINE MED/96141169; Aubry P; Larouze B; Muhirwa G; Henzel D; Ndabaneze E; Nsabimana JM; Departement de Medecine Interne, Centre Hospitalier; Universitaire Kamenge, Bujumbura, Burundi.; A case/control study was conducted in Bujumbura, Burundi , from 1991 to 1992 to assess the relationship between chronic liver disease and hepatitis C virus (HCV). Patients presenting chronic liver disease (n = 80) were selected based on clinical, laboratory, ultrasonographic, and/o
[Kaposi's sarcoma in dermatology consultations at Lome, Togo]: Med Trop (Mars). 1995;55(3):246-8. Unique Identifier : AIDSLINE MED/96141172; Pitche P; Kombate K; Napo-Koura G; Mijiyawa M; Tchangai-Walla K; Service de Dermatologie, Centre Hospitalier Universitaire Tokoin,; Lome, Togo.; The purpose of this retrospective study conducted in a dermatologic out patient clinic in Lome was to assess the epidemiologic, clinical, and prognostic profile of Kaposi s sarcoma in Togo during the 15 years period between 1980 and 1994. Only patients who had undergone serologic tes
[Bilharziasis and human immunodeficiency virus infection in Congo]: Med Trop (Mars). 1995;55(3):249-51. Unique Identifier : AIDSLINE MED/96141173; N'Zoukoudi-N'Doundou MY; Dirat I; Akouala JJ; Penchenier L; Makuwa M; Rey JL; Laboratoire d'Epidemiologie des Grandes Endemies Tropicales,; Brazzaville, Congo.; To assess the relationship between schistosomiasis and human immunodeficiency virus (HIV) infection, a cross-sectional study of HIV seroprevalence was carried out in 1992 in a village in the Bouenza region of the Congo where there is a high incidence of urinary schistosomiasis. No correlation was found between eggs in
[Autopsy findings in 70 AIDS patients who died in a department of pneumology in Ivory Coast: impact of tuberculosis]: Med Trop (Mars). 1995;55(3):252-4. Unique Identifier : AIDSLINE MED/96141174; Domoua K; N'Dhatz M; Coulibaly G; Traore F; Konan JB; Lucas S; Beaumel A; De Cock KM; Dago-Akribi A; Yapi A; Service de Pneumo-phtisiologie, Centre Hospitalier Universitaire; de Treichville, Projet RETRO-CI, Cote d'Ivoire.; Based on autopsy findings in 70 patients infected by human immunodeficiency virus (HIV) who died in the Pulmonology Department of the Treichville University Hospital Center in Abidjan, Ivory Coast . the authors assess the incidence of tuberculosis as the cause of death and anal
[Noma or cancrum oris: etiopathogenic and nosologic aspects]: Med Trop (Mars). 1995;55(3):263-73. Unique Identifier : AIDSLINE MED/96141177; Costini B; Larroque G; Duboscq JC; Montandon D; Service de Chirurgie Maxillo-faciale et Plastique de la Face,; Centre Hospitalier Universitaire Nord, Marseille, France.; Noma is a gangrenous disease that usually begins in the mouth and is characterized by rapid necrotizing destruction of soft tissue and underlying bone. The disease, which is associated with a strong putrid odor suggestive of mixed bacterial infection, develops only in predisposed persons, especially children whose nat
A new wave of treatments for HIV infection is on the horizon.: Mo Med. 1995 Oct;92(10):638-9. Unique Identifier : AIDSLINE MED/96072283; McKinsey D; Kansas City AIDS Research Consortium, USA.
Mycetoma due to Exophiala jeanselmei and Mycobacterium chelonae in a 73-year-old man with idiopathic CD4+ T lymphocytopenia.: Mycoses. 1995 Jul-Aug;38(7-8):271-6. Unique Identifier : AIDSLINE MED/96129847; Neumeister B; Zollner TM; Krieger D; Sterry W; Marre R; Abteilung Medizinische Mikrobiologie und Hygiene, Instituts fur; Medizinische Mikrobiologie und Immunologie, Ulm, Germany.; Exophiala jeanselmei and Mycobacterium chelonae were isolated from cutaneous nodules in a 73-year-old man with mycetoma of the right lower leg. Further evaluation revealed CD4+ lymphocytopenia without evidence of HIV infection. Antibodies to HIV 1/2, p24 antigen and HIV 1/2 (PCR) and reverse transcriptase activity wer
Herpesvirus-like DNA sequence in angiosarcoma in a patient without HIV infection [letter]: N Engl J Med. 1996 Feb 22;334(8):540-1. Unique Identifier : AIDSLINE MED/96157034; Gyulai R; Kemeny L; Kiss M; Adam E; Nagy F; Dobozy A
Tokyo professor accused of perjury over evidence of HIV infection [news]: Nature. 1996 Feb 1;379(6564):388. Unique Identifier : AIDSLINE MED/96158862
[Frequency and mode of use of testing for HIV infection in women hospitalized for childbirth]: Minerva Ginecol. 1995 Oct;47(10):439-45. Unique Identifier : AIDSLINE MED/96158251; Puro V; Romano S; De Santis MT; Aloisi MS; D'Ubaldo C; Girardi E; Ippolito G; Centro di Riferimento AIDS, Ospedale L. Spallanzani, Roma.; OBJECTIVE: To assess the use of HIV testing because of pregnancy. DESIGN: Cross-sectional study. PATIENTS: Parturients admitted to the obstetric divisions of a public hospital located in Rome (February-April 1994). INTERVENTION: Standardized interview during post test counseling. OUT-COMES: Frequency and characteristi
Pregnancy rates among women infected with human immunodeficiency virus. Adult/Adolescent HIV Spectrum of Disease Project Group.: Obstet Gynecol. 1996 Feb;87(2):195-8. Unique Identifier : AIDSLINE MED/96148892; Chu SY; Hanson DL; Jones JL; Division of HIV/AIDS Prevention, Centers for Disease Control and; Prevention, Atlanta, Georgia, USA.; OBJECTIVE: To examine pregnancy rates among women infected with human immunodeficiency virus (HIV). METHODS: We used data from an ongoing survey of medical records of 3915 women who were 15-44 years of age, infected with HIV, and who received care between January 1990 and August 1994 in more than 90 clinics, hospitals
Myelopathy as a presenting sign of acquired immunodeficiency syndrome.: Pediatr Infect Dis J. 1995 Sep;14(9):808-9. Unique Identifier : AIDSLINE MED/96079361; Fiser RT; Hickerson SL; Sharp GB; Schutze GE; University of Arkansas for Medical Science, Little Rock, USA.
How long may perinatally acquired human immunodeficiency virus infection last asymptomatically? [letter]: Pediatr Infect Dis J. 1995 Sep;14(9):821-2. Unique Identifier : AIDSLINE MED/96079370; Manfredi R; Ragazzini I; Zucchini A; Di Fiore MT; Manfredi G
Maddening inaction [news]: Nurs Times. 1995 Dec 13-19;91(50):14-5. Unique Identifier : AIDSLINE MED/96153294; Day M
[Informing a child about his illness in HIV infection: words and meaning]: Psychiatr Enfant. 1995;38(1):109-39. Unique Identifier : AIDSLINE MED/96137090; Funck-Brentano I; Departement de Pediatrie, Hopital Necker-Enfants malades.; The account of the medical and psychological treatment of Pascal over a period of three years shows the complexity and the stakes of the problem that families and the medical core are faced with when confronted to a child infected by the HIV: to talk of his infection or his illness. How do you approach the problem wit
Comments on Alcohol use and risky sex among college students.: Psychol Rep. 1995 Oct;77(2):421-2. Unique Identifier : AIDSLINE MED/96130884; Ridley DR; Greenlee SP; Department of Psychology, Christopher Newport University, Newport; News, VA 23606-2988, USA.
Willingness to work with and sympathy for HIV-positive coworkers: an experimental examination of mode of transmission concern, and knowledge.: Psychol Rep. 1995 Oct;77(2):571-6. Unique Identifier : AIDSLINE MED/96130900; Zagumny MJ; Deckbar R; Tennessee Technological University, Department of School Services; Personnel and Psychology, Cookeville 38505, USA.; This study investigated concern about HIV infection, knowledge about HIV/AIDS, and mode of transmission on willingness to work with and sympathy expressed towards a coworker with AIDS. 120 undergraduate students were randomly assigned to one of 12 groups in a 3 x 4 between-subjects design. Subjects viewed one of three
Gender differences of reported safer sex behaviors within a random sample of college students.: Psychol Rep. 1995 Dec;77(3 Pt 1):963-8. Unique Identifier : AIDSLINE MED/96130949; Hawkins WE; Gray C; Hawkins WE; Catholic University of America, National Catholic School of; Social Service, Washington, DC 20064, USA.; This study investigated the frequency of safer sex behaviors with a random sample of sexually active college students (N = 315) at a university in the Northwest. The most frequent safer sex behaviors were discussion of contraceptives (58.6%), being more selective (46.5%), and reducing the number of sexual partners (43
How many HIV infections are there in Israel? Reconstructing HIV incidence from AIDS case reporting.: Public Health Rev. 1995;23(3):215-35. Unique Identifier : AIDSLINE MED/96137686; Kaplan EH; Slater PE; Soskolne V; Hebrew University-Hadassah Braun School of Public Health and; Community Medicine, Jerusalem, Israel.; BACKGROUND: The reporting of AIDS cases to Israel s Ministry of Health is believed to be accurate, but the completeness of HIV surveillance is unknown. We implement a model that reconstructs HIV incidence in Israel from AIDS case reports excluding Ethiopian immigrants. METHODS: We apply the well-known method of backca
[Parasitic and viral marker detection in pregnant adolescents and their newborn infants at risk]: Rev Chil Obstet Ginecol. 1995;60(2):85-9. Unique Identifier : AIDSLINE MED/96093537; Contreras MC; Escaff V; Salinas P; Saavedra T; Suarez M; Departamento de Parasitologia, Facultad de Medicina, Universidad; de Chile.; We have investigated the prevalence of antibodies against Toxoplasma gondii, Trypanosoma cruzzi, Hepatitis B virus, cytomegalovirus , rubella virus, and human immunodeficiency virus in 139 adolescent pregnant women and in their high risk newborn children. The methods employed were t
[Muscle pain and swelling in a HIV-positive patient]: Rev Clin Esp. 1995 Nov;195(11):811-2. Unique Identifier : AIDSLINE MED/96158300; de la Fuente Aguado J; Moreno Sanjuan JA; Martinez-Vazquez C; Estevez Diz A; Fernandez Villar A; Sopena Perez-Arguelles B; Servicio de Medicina Interna, Unidad de Enfermedades Infecciosas,; Complejo Hospitalario Xeral-Cies, Vigo.
[Ischemic cerebrovascular incident associated with crack consumption (letter)]: Rev Clin Esp. 1995 Nov;195(11):814. Unique Identifier : AIDSLINE MED/96158302; Santamaria A; Ormaechea E; Guardiola J; Domingo P
Probability and characteristics of human immunodeficiency virus infection in male Greek military personnel with tuberculosis.: Respiration. 1995;62(5):280-5. Unique Identifier : AIDSLINE MED/96079419; Bouros D; Panagou P; Tzanakis N; Siafakas N; Department of Thoracic Medicine, Medical School, University of; Crete, Heraklion, Greece.; The probability of an AIDS patient being infected with tuberculosis (TB) has been studied in different populations and found to be increased by as much as 500 times, but the reverse, i.e. the probability of a patient with TB being infected with HIV, has not been studied. The aim of this study was to investigate the hy
[Microsporidiosis in patients with chronic diarrhea and AIDS, in HIV asymptomatic patients and in patients with acute diarrhea]: Rev Med Chil. 1995 Jul;123(7):849-56. Unique Identifier : AIDSLINE MED/96093577; Weitz JC; Botehlo R; Bryan R; Departamento de Medicina, Facultad de Medicina (Campus Oriente),; Universidad de Chile, Santiago de Chile.; Microsporidia are intracellular protozoa that mainly affect AIDS patients and chronic diarrhea, caused by the strains Enterocytozoon bieneusi and Septata intestinalis, is the most common clinical manifestation. The diagnosis is made in intestinal biopsies, however the recently developed trichromic stain with chromotro
[HIV-associated nephropathy]: Rev Hosp Clin Fac Med Sao Paulo. 1995 Jul-Aug;50(4):189-90. Unique Identifier : AIDSLINE MED/96093558; de Menezes MR; de Oliveira IR; Saito O de C; Instituto de Radiologia, Hospital das Clinicas, Faculdade de; Medicina, USP.; AIDS can affect many parenchymal organs but the renal involvement is of vital value for patient s prognosis. Sonography can easily analyse most of all renal insult even in those patients without symptoms.
[Facial and cervical manifestations of AIDS]: Rev Hosp Clin Fac Med Sao Paulo. 1995 Jul-Aug;50(4):222-6. Unique Identifier : AIDSLINE MED/96093564; Gebrim EM; Gomes RL; Bambirra S; Rocha M de S; Setor de Tomografia Computadorizada, Hospital das Clinicas,; Faculdade de Medicina da USP.; The manifestations of the acquired immunodeficiency syndrome (AIDS) are common in the head and neck and include opportunistic infections, malignancies and diffuse reactive adenopathy. This article reviews the usual and unusual manifestation of AIDS affections of the parotid gland, sinonasal and oral cavity, nasopharyn
HLA-B27-restricted cytotoxic T lymphocyte responses to arthritogenic enterobacteria or self-antigens are dominated by closely related TCRBV gene segments. A study in patients with reactive arthritis.: Scand J Immunol. 1996 Jan;43(1):101-8. Unique Identifier : AIDSLINE +; Duchmann R; May E; Ackermann B; Goergen B; Meyer zum Buschenfelde KH; Marker-Hermann E; First Department of Medicine, Johannes Gutenberg University of; Mainz, Germany.; Identification of the T-cell receptors (TCR) used by synovial cytotoxic T lymphocytes (CTL) of patients with reactive arthritis (ReA) may be crucial to better understanding the pathogenetic mechanism underlying the HLA-B27 association of spondylarthropathies. The authors, therefore, sequenced 25 TCRB chains from HLA-B
Chagasic patients lack CD28 expression on many of their circulating T lymphocytes.: Scand J Immunol. 1996 Jan;43(1):88-93. Unique Identifier : AIDSLINE MED/96151206; Dutra WO; Martins-Filho OA; Cancado JR; Pinto-Dias JC; Brener Z; Gazzinelli G; Carvalho JF; Colley DG; Centro de Pesquisas Rene Rachou, FIOCRUZ, Belo Horizonte,; Brazil.; A balanced host-parasite interaction during Trypanosoma cruzi infection allows for the establishment of a chronic infection that can last for many years. T cells are a major element responsible for parasite specific and non-specific immunity during the complex immune response of the host. However, the subpopulations o
IFN-gamma restores HIV- and non-HIV-specific cell mediated immune response in vitro and its activity is neutralized by antibodies from patients with AIDS.: Scand J Immunol. 1996 Jan;43(1):94-100. Unique Identifier : AIDSLINE MED/96151207; De Francesco MA; Caruso A; Dima F; Cantalamessa A; Canaris AD; Folghera S; Fiorentini S; Flamminio G; Licenziati S; Peroni L; Gao J; Garotta G; Turano A; Insitute of Microbiology, University of Brescia, Italy.; The addition of IFN-gamma to cultures of peripheral blood mononuclear cells (PBMCs) obtained from asymptomatic HIV-infected patients increased cell proliferation in response to HIV envelope synthetic peptides (Env), influenza A virus (VIRUS), and allogeneic lymphocytes (ALLO) but not to phytohaemagglutinin (PHA) stimu
AIDS task force fizzles out [news]: Science. 1996 Jan 26;271(5248):438-9. Unique Identifier : AIDSLINE MED/96152354; Cohen J
Can some infants beat HIV? [news]: Science. 1996 Jan 26;271(5248):441. Unique Identifier : AIDSLINE MED/96152356; Thompson C
Reduction of HIV concentration during acute infection: independence from a specific immune response.: Science. 1996 Jan 26;271(5248):497-9. Unique Identifier : AIDSLINE MED/96152367; Phillips AN; Department of Primary Care and Population Sciences, Royal Free; Hospital School of Medicine, London, UK.; After infection with the human immunodeficiency virus (HIV), the concentration of the virus in the person s plasma increases. The subsequent decrease in concentration a few weeks later was though to result from an HIV-specific immune response. This purported causal relation is investigated with a model of the dynamics
Transfusion-dependent thalassemia: viral complications (epidemiology and follow-up).: Semin Hematol. 1995 Oct;32(4):280-7. Unique Identifier : AIDSLINE MED/96124305; de Montalembert M; Girot R; Mattlinger B; Lefrere JJ; Centre de Transfusion, Hopital Necker, Paris, France.
Social interventions in the care of human immunodeficiency virus (HIV)-infected pregnant women.: Semin Perinatol. 1995 Aug;19(4):323-9. Unique Identifier : AIDSLINE MED/96076548; Levine C; Allen MH; Orphan Project: Families and Children in the HIV Epidemic, New; York, NY 10013, USA.; The incidence of infection with the human immunodeficiency virus (HIV) is increasing among women of childbearing age. Women now account for 18% of the total number of cases of the acquired immunodeficiency syndrome (AIDS), compared with 9% a decade ago. The medical care of pregnant HIV-infected women must take into ac
Fear of AIDS and homophobia: implications for direct practice and advocacy.: Soc Work. 1996 Jan;41(1):51-8. Unique Identifier : AIDSLINE MED/96151936; O'Hare T; Williams CL; Ezoviski A; Graduate School of Social Work, Boston College, Chestnut Hill, MA; 02167-3807, USA.; Studies of health care trainees and professionals have demonstrated that their level of empathy and caring is negatively affected by the knowledge that the person being treated is homosexual, in part because of stigma associated with HIV infection and AIDS. The survey discussed in this article examined the relationshi
Understanding the social needs of streetwalking prostitutes.: Soc Work. 1996 Jan;41(1):97-105. Unique Identifier : AIDSLINE MED/96151940; Weiner A; Wurzweiler School of Social Work, Yeshiva University, New York,; NY 10033, USA.; The social dynamics of prostitution render prostitutes unable at times to meet basic human needs, vulnerable to violence, and at risk for sexually transmitted disease. Since April 1989 a mobile van from a private foundation has been contacting prostitutes throughout the five boroughs of New York City to provide HIV te
Primary xanthoma of thoracic spine presenting with myelopathy.: Spine. 1995 Sep 1;20(17):1933-7. Unique Identifier : AIDSLINE MED/96060156; Robertson DP; Langford LA; McCutcheon IE; Department of Neurosurgery, University of Texas M. D. Anderson; Cancer Center, Houston, USA.; STUDY DESIGN. This retrospective case study reports on a patient with an isolated primary xanthoma arising in the second thoracic vertebra with paravertebral and spinal canal extension. OBJECTIVE. The possibility of this lesion s occurrence in the spine is presented with radiologic and pathologic findings appropriate
Occupational stress among AIDS social service providers.: Soc Work Health Care. 1995;21(3):115-31. Unique Identifier : AIDSLINE MED/96131848; Cushman LF; Evans P; Namerow PB; Center for Population and Family Health, Columbia University; School of Public Health, USA.; This survey reveals high levels of job-related stress among social workers, counselors and health educators working with HIV/AIDS patients in five large, urban medical centers. Stress is associated not only with the severity of AIDS as a disease, but also with several organizational characteristics of respondents job
Tuberculosis and AIDS: the impact on the hospital social worker.: Soc Work Health Care. 1995;21(3):29-41. Unique Identifier : AIDSLINE MED/96131844; Wade K; Stein E; Beckerman N; The second decade of the AIDS epidemic is marked by increasing numbers of people being diagnosed with HIV infection as well as mycobacterium infection (pulmonary tuberculosis). The convergence of these two epidemics presents new challenges for social workers. Serious threat of HIV infection from occupational exposure
Psychosocial outcomes of HIV illness in male and female African American clients.: Soc Work Health Care. 1995;21(3):43-60. Unique Identifier : AIDSLINE MED/96131845; Linn JG; Poku KA; Cain VA; Holzapfel KM; Crawford DF; Tennessee State University, Murfreesboro, USA.; With the rapid growth of HIV infection among African Americans, the issue of how medical problems relate to psychological functioning in the black community population has acquired new meaning and urgency for health care policy. To develop effective strategies to meet the mental health needs of infected African Americ
Occupational exposure of health care workers (HCWs) to human immunodeficiency virus (HIV): stress reactions and counseling interventions.: Soc Work Health Care. 1995;21(3):61-80. Unique Identifier : AIDSLINE MED/96131846; Armstrong K; Gorden R; Santorella G; University of California, San Francisco, USA.; As more people become infected with HIV, Health Care Workers (HCWs) have a greater likelihood of being exposed at work. HIV exposure threatens the life of the HCW and can elicit a stress reaction. Although HCWs have reactions similar to those of people who have been exposed to other traumatic events, the nature of thi
Racial minorities and other high-risk groups with HIV and AIDS at increased risk for psychological adjustment problems in association with health locus of control orientation.: Soc Work Health Care. 1995;21(3):81-114. Unique Identifier : AIDSLINE MED/96131847; Spalding AD; SUNY College, Department of Health Sciences, 14420, USA.; This study compared minority subjects (n = 45) with non-minority subjects (n = 49) with HIV and AIDS, examining levels of perceived locus of control over health status, and whether different health locus of control (HLOC) orientations (internal, powerful others, or chance) determined psychological adjustment as measur
Social work with dying and bereaved clients: helping the workers.: Soc Work Health Care. 1995;21(4):1-16. Unique Identifier : AIDSLINE MED/96134620; Davidson KW; Foster Z; Hunter College School of Social Work, New York, NY 10021, USA.; This paper considers the stresses and satisfactions experienced by health care social workers as they help clients with grief and loss at a time of great fiscal restraint. Their clients face life-threatening illnesses such as AIDS and many forms of cancer. There are untimely losses in families and communities whose re
Five-year follow-up of human anti-mouse antibody in multitransfused HIV negative haemophilics treated with a monoclonal purified plasma derived factor VIII concentrate [letter]: Thromb Haemost. 1995 Oct;74(4):1203. Unique Identifier : AIDSLINE MED/96124420; Smid WM; van der Meer J
High prevalence of Enterocytozoon bieneusi infections among HIV-positive individuals with persistent diarrhoea in Harare, Zimbabwe.: Trans R Soc Trop Med Hyg. 1995 Sep-Oct;89(5):478-80. Unique Identifier : AIDSLINE MED/96142781; van Gool T; Luderhoff E; Nathoo KJ; Kiire CF; Dankert J; Mason PR; Department of Medical Microbiology, University of Amsterdam, The; Netherlands.; Infection with the microsporidian parasite Enterocytozoon bieneusi may be a major cause of prolonged diarrhoea in individuals also infected with human immunodeficiency virus (HIV). The parasite has been reported from Europe, Australia and the Americas, with a prevalence of 7-29%
Prevalence of hepatitis C virus and other blood-borne viruses in Pygmies and neighbouring Bantus in southern Cameroon.: Trans R Soc Trop Med Hyg. 1995 Sep-Oct;89(5):484-6. Unique Identifier : AIDSLINE MED/96142783; Kowo MP; Goubau P; Ndam EC; Njoya O; Sasaki S; Seghers V; Kesteloot H; Department of Gastroenterology and Nutrition, University of; Yaounde, Cameroon.; The prevalences of antibodies to hepatitis C virus (anti-HCV), human immunodeficiency virus (anti-HIV), human T lymphotrophic virus (anti-HTLV) and of hepatitis B surface antigen (HbsAg) were determined in 168 subjects aged 12 years and over (108 Pygmies, 60 Bantus) living in south C
Hodgkin's disease after transplantation.: Transplantation. 1996 Jan 15;61(1):71-6. Unique Identifier : AIDSLINE MED/96144871; Garnier JL; Lebranchu Y; Dantal J; Bedrossian J; Cahen R; Assouline D; Jaccard A; Fetissoff F; Moreau A; Martin X; Delsol G; Berger F; Touraine JL; Inserm U80, Service d'Urologie, Departement d' Hematologie,; Hopital Edouard Herriot, Lyon, France.; Hodgkin s disease (HD) has seldom been reported after transplantation. Epstein-Barr virus (EBV) is present in about 50% of Reed-Sternberg cells in HD developing in immunocompetent individuals, but is more frequently found in HD of acquired immune deficiency syndrome patients. We report 7 cases of HD that occurred in t
The role of endogenous glucocorticoids on host T cell populations in the peripheral lymphoid organs of mice with graft-versus-host disease.: Transplantation. 1996 Jan 15;61(1):76-83. Unique Identifier : AIDSLINE MED/96144872; You-Ten KE; Lapp WS; Department of Physiology, McGill University, Montreal, Quebec,; Canada.; Previously, we demonstrated that immature CD4+8+ and mature CD4+ thymocyte populations were selectively eliminated during murine graft-versus-host disease (GVHD) as a consequence of elevated levels of endogenous glucocorticoids. In this report, we investigated whether the marked reduction of CD4+8+ and CD4+ thymocyte
The changing pattern of mortality in an African medical ward.: Trop Geogr Med. 1995;47(4):171-4. Unique Identifier : AIDSLINE MED/96085991; Harries AD; Mvula B; Department of Medicine, Queen Elizabeth Central Hospital,; Blantyre, Malawi.; The pattern of adult medical deaths in Queen Elizabeth Central Hospital, Blantyre, Malawi was documented over a 12 month period between April 1992 and March 1993. Results were compared with mortality data collected from the same wards in the pre-AIDS era in 1973. Tuberculosis and A
N-linked glycans in the CD4-binding domain of human immunodeficiency virus type 1 envelope glycoprotein gp160 are essential for the in vivo priming of T cells recognizing an epitope located in their vicinity.: Virology. 1996 Jan 15;215(2):124-33. Unique Identifier : AIDSLINE MED/96146726; Sjolander S; Bolmstedt A; Akerblom L; Horal P; Olofsson S; Morein B; Sjolander A; Department of Veterinary Microbiology, College of Veterinary; Medicine, Swedish University of Agricultural Sciences, Uppsala,; Sweden.; Deglycosylation of viral glycoproteins has been suggested to influence the number of available T cell determinants and to increase T cell recognition of antigens. In this study, we have investigated whether T cell responses to the HIV-1 envelope glycoprotein gp160 were influenced by deletion of three N-glycans of the
Coexpression of a nonsyncytium inducer HIV-1 glycoprotein inhibits syncytium formation by another HIV-1 Env protein.: Virology. 1996 Jan 15;215(2):197-202. Unique Identifier : AIDSLINE MED/96146734; Li YY; O'Donnell MA; Perez LG; Molecular Biology and Biotechnology Program, Salem-Teikyo; University-Tampa Bay Research Institute, St. Petersburg, Florida; 33716, USA.; The biosynthesis and biological properties of the envelope glycoprotein from a primary isolate of the human immunodeficiency virus type 1, HIV-1 YU2, and the Env product from the laboratory-adapted strain, HIV-1 LAI were compared in the absence of viral replication. We found that the level of expression and proteolyti
Molecular analysis of human T-cell lymphotropic virus type II from Wayuu Indians of Colombia demonstrates two subtypes of HTLV-IIb.: Virus Genes. 1995;10(2):153-62. Unique Identifier : AIDSLINE GENBANK/U12795; Switzer WM; Owen SM; Pieniazek DA; Nerurkar VR; Duenas-Barajas E; Heneine W; Lal RB; Retrovirus Diseases Branch, Centers for Disease Control and; Prevention, Atlanta, Georgia 30333, USA.; Studies of the genetic heterogeneity of human T-cell lymphotropic virus type II (HTLV-II) have revealed the presence of two genetic subtypes, termed HTLV-IIa and HTLV-IIb. The HTLV-IIb subtype encodes an immunodominant epitope present at the C-terminus of the extended Tax protein and, by using an LTR-based, restrictio
Computer simulations to predict the availability of peptides with known HLA class I motifs possibly generated by proteolysis of HIV-1 proteins in infected cells.: Virus Genes. 1995;10(3):227-37. Unique Identifier : AIDSLINE MED/96124518; Becker Y; Department of Molecular Virology, Faculty of Medicine, Hebrew; University of Jerusalem, Israel.; Cytotoxic T cells that recognize HIV-1 peptides generated from all viral proteins were reported. To predict the cleavage pattern of HIV-1 proteins by cytoplasmic proteasomes into peptides with motifs fitting known HLA class I molecules, the computer program Findpatterns was used. In this paper the combined amino acids
[Distribution of p27 and gp70 feline leukemia virus antigens in various tissues]: Vojnosanit Pregl. 1994 Jul-Aug;51(4):277-80. Unique Identifier : AIDSLINE MED/96141625; Kovacevic S; Knezevic M; Univerzitet u Beogradu, Veterinarski fakultet, Katedra za; patolosku morfologiju, Beograd.; Application of immunocytochemical methods (DP, IP, PAP, APAAP and IP-IP) has confirmed the existence of p27 and gp70 feline leukosis viral antigens (FeLV) in various tissues of 22 cats. Both viral antigens were found in bone marrow stem cells, but p27 antigens were mostly found in epithelial cells of intestinal crypts
[Erectile dysfunction in patients with type I diabetes mellitus]: Wien Med Wochenschr. 1995;145(21):584-6. Unique Identifier : AIDSLINE MED/96118197; Brunner GA; Pieber TR; Schattenberg S; Ressi G; Wieselmann G; Altziebler S; Krejs GJ; Medizinischen Universitatsklinik, Graz.; To improve diabetes care according to the St. Vincent Declaration an interdisciplinary working group on erectile dysfunction in patients with diabetes was installed in the Departments of Internal Medicine, Urology and Psychiatry at the University of Graz. The screening and basic diagnostic procedures are performed in
Cytomegalovirus infection of the brain in AIDS: a clinicopathological study.: Acta Neuropathol (Berl). 1995;90(5):511-5. Unique Identifier : AIDSLINE MED/96136529; Setinek U; Wondrusch E; Jellinger K; Steuer A; Drlicek M; Grisold W; Lintner F; Institute of Pathology and Bacteriology, Vienna, Austria.; Based on neuropathological findings, a retrospective case control study of 39 patients with acquired immune deficiency syndrome (AIDS) and confirmed cytomegalovirus ( CMV ) infection of the brain is presented. Since 1989, the i
Elevated plasma concentration of reduced homocysteine in patients with human immunodeficiency virus infection.: Am J Clin Nutr. 1996 Feb;63(2):242-8. Unique Identifier : AIDSLINE MED/96148838; Muller F; Svardal AM; Aukrust P; Berge RK; Ueland PM; Froland SS; Medical Department A, University of Oslo, National Hospital,; Norway.; Oxidative stress has been suggested to be an important factor in the immunopathogenesis of human immunodeficiency virus (HIV) infection. Reduced plasma thiols may lead to production of reactive oxygen species, thus contributing to the oxidative stress. We quantified the total, reduced, and protein-bound forms of the t
A rapid and inexpensive method for processing induced sputum for detection of Pneumocystis carinii.: Am J Clin Pathol. 1996 Jan;105(1):52-7. Unique Identifier : AIDSLINE MED/96143465; Rocha P; Awe RJ; Guy ES; Gaines V; Banez EI; Stager CE; Guntupalli KK; Department of Pulmonary Medicine, Ben Taub General Hospital,; Houston, TX 77030, USA.; The authors describe a method to process induced sputum specimens for detection of Pneumocystis carinii which is simple, rapid and inexpensive. Induced sputum and bronchoalveolar lavage (BAL) were obtained within a 24-hour period from 41 patients who were HIV-positive and had pulmonary symptoms suspicious for P carini
Gender differences in high-risk sex behaviours among heterosexual drug injectors and crack smokers.: Am J Drug Alcohol Abuse. 1995 Nov;21(4):419-32. Unique Identifier : AIDSLINE MED/96112353; Booth RE; Department of Psychiatry, University of Colorado Health Sciences; Center, Denver 80211, USA.; This study was designed to assess gender differences in high-risk sex behaviors related to the transmission of HIV among injection drug users (IDUs) and crack smokers. Using a standard national survey instrument, 593 verified drug users were questioned about their sexual activities and drug use in the 30 day period pr
Subacute mitochondrial liver disease in a patient with AIDS: possible relationship to prolonged fluconazole administration.: Am J Gastroenterol. 1996 Jan;91(1):165-8. Unique Identifier : AIDSLINE MED/96145309; Guillaume MP; De Prez C; Cogan E; Department of Internal Medicine, Hopital Universitaire Brugmann,; Belgium.; Azole-derived antifungal medications are particularly involved in drug-induced hepatic injury encountered in patients with AIDS. Fluconazole may induce multiple hepatic abnormalities usually characterized by asymptomatic and reversible mild hepatic necrosis. We here describe severe subacute liver damage occurring in a
Cytomegalovirus colitis mimicking colon carcinoma in an HIV-negative patient with chronic renal failure.: Am J Gastroenterol. 1996 Jan;91(1):168-9. Unique Identifier : AIDSLINE MED/96145310; Falagas ME; Griffiths J; Prekezes J; Worthington M; Department of Medicine, St. Elizabeth's Medical Center at Boston,; Massachusetts 02135, USA.; Cytomegalovirus ( CMV ) colitis is thought to occur almost exclusively in immunosuppressed persons. Colonoscopy in patients with CMV colitis usually shows diffuse or localized ulceration, although mucosal friability, erosions, hemorrhage, and plaque-like pseudomem
Primary rectal Hodgkin's lymphoma: initial manifestation of HIV [letter]: Am J Gastroenterol. 1996 Jan;91(1):180-1. Unique Identifier : AIDSLINE MED/96145319; Ranganathan V
Temporal trends of initial CD4 cell counts following human immunodeficiency virus seroconversion in Italy, 1985-1992. The Human Immunodeficiency Virus Italian Seroconversion Study.: Am J Epidemiol. 1996 Feb 1;143(3):278-82. Unique Identifier : AIDSLINE MED/96148853; Galai N; Lepri AC; Vlahov D; Pezzotti P; Sinicco A; Rezza G; Department of Epidemiology, School of Hygiene and Public Health,; Johns Hopkins University, Baltimore, MD, USA.; To determine whether initial CD4 cell counts after human immunodeficiency virus (HIV) seroconversion have decreased over calendar time among participants in the Italian Seroconversion Study, HIV seroconverters who between 1985 and 1992 had a documented negative serology followed by a positive serology within 12 months
A double-blind trial of haloperidol, chlorpromazine, and lorazepam in the treatment of delirium in hospitalized AIDS patients.: Am J Psychiatry. 1996 Feb;153(2):231-7. Unique Identifier : AIDSLINE MED/96155935; Breitbart W; Marotta R; Platt MM; Weisman H; Derevenco M; Grau C; Corbera K; Raymond S; Lund S; Jacobson P; Department of Neurology, Memorial Sloan-Kettering Cancer Center,; New York, NY 10021, USA.; OBJECTIVE: The purpose of this study was to examine the efficacy and side effects of haloperidol, chlorpromazine, and lorazepam for the treatment of the symptoms of delirium in adult AIDS patients in a randomized, double-blind, comparison trial. METHOD: Nondelirious, medically hospitalized AIDS patients (N = 244) cons
Interest in physician-assisted suicide among ambulatory HIV-infected patients.: Am J Psychiatry. 1996 Feb;153(2):238-42. Unique Identifier : AIDSLINE MED/96155936; Breitbart W; Rosenfeld BD; Passik SD; Department of Neurology, Memorial Sloan-Kettering Cancer Center,; New York, NY 10021, USA.; OBJECTIVE: This study surveyed HIV-infected patients attitudes toward physician-assisted suicide and examined the relationship between interest in physician-assisted suicide and physical and psychosocial variables. METHOD: Three hundred seventy-eight ambulatory HIV-infected patients, 90% of whom met the criteria of t
Predominant CD8+ infiltrate in limb biopsies of individuals with filarial lymphedema and elephantiasis.: Am J Trop Med Hyg. 1995 Dec;53(6):633-8. Unique Identifier : AIDSLINE MED/96155958; Freedman DO; Horn TD; Maia e Silva CM; Braga C; Maciel A; Division of Geographic Medicine, University of Alabama at; Birmingham, USA.; In 34 individuals with a spectrum of clinical manifestations of Bancroftian filariasis, we investigated whether immunoperoxidase-stained, random, superficial dermal biopsies could further elucidate the nature of the diffuse damage to superficial lymphatics that had been recently demonstrated by radionuclide lymphoscin
Epidemiology of isosporiasis among persons with acquired immunodeficiency syndrome in Los Angeles County.: Am J Trop Med Hyg. 1995 Dec;53(6):656-9. Unique Identifier : AIDSLINE MED/96155964; Sorvillo FJ; Lieb LE; Seidel J; Kerndt P; Turner J; Ash LR; HIV Epidemiology Program, Los Angeles County Department of Health; Services, California, USA.; To determine factors associated with isosporiasis in persons with acquired immunodeficiency syndrome (AIDS) in Los Angeles County, data from the AIDS surveillance registry were analyzed for the eight-year period 1985-1992. Isosporiasis was reported in 127 (1.0%) of 16,351
Alcohol ingestion impairs host defenses predisposing otherwise healthy mice to Pneumocystis carinii infection.: Alcohol Clin Exp Res. 1995 Oct;19(5):1219-25. Unique Identifier : AIDSLINE MED/96119379; D'Souza NB; Mandujano JF; Nelson S; Summer WR; Shellito JE; Section of Pulmonary and Critical Care Medicine, Louisiana State; University Medical Center, New Orleans 70112, USA.; Pulmonary infection with Pneumocystis carinii, an opportunistic pathogen, is associated with a variety of immunosuppressive states, including human immunodeficiency virus infection. We hypothesized that alcohol ingestion might compromise host defenses against this pathogen and, in an immunocompromised host, increase t
Effects of prenatal ethanol exposure and stress in adulthood on lymphocyte populations in rats.: Alcohol Clin Exp Res. 1995 Oct;19(5):1286-94. Unique Identifier : AIDSLINE MED/96119388; Giberson PK; Weinberg J; Department of Anatomy, University of British Columbia, Vancouver,; Canada.; The present study was undertaken to assess the possible interactive effects of prenatal ethanol exposure and stress in adulthood on lymphocyte populations in rat offspring, and to examine differential vulnerability of males and females to these challenges. Male and female offspring from prenatal ethanol-exposed (E), p
[Study on the prevention of HIV transmission between patients in the psychiatric hospital milieu]: Ann Med Psychol (Paris). 1995 Oct;153(8):512-6; discussion 516-7. Unique Identifier : AIDSLINE MED/96150554; Charmasson C; Georgieff A; Veil C; A survey of staff opinion using anonymous questionnaires was conducted simultaneously in five French psychiatric hospitals in January and February 1995. The 36 questions concerned collective HIV prevention practices for hospitalised patients, actual participation in various actions, and personal choice and judgement c
[Malignant non-Hodgkin lymphoma of cardiac localization.Apropos of a case]: Ann Cardiol Angeiol (Paris). 1995 Sep;44(7):345-8. Unique Identifier : AIDSLINE MED/96144914; Ghannem M; Godard S; Trylesinski A; Duhamel P; Philippe J; Sabbah L; Belhani A; Centre Medical et Cardiologique Leopold Bellan Ollencourt,; Tracy-le-Mont.; Malignant non-Hodgkin s lymphomas are rare in the absence of human immunodeficiency virus infection and it is exceptional for a cardiac site to be the prominent feature. In our case, the malignant lymphoma was revealed by pericardial effusion in a context of alteration of the general state. Echocardiography revealed a
Ribonuclease H activity during initiation of reverse transcription using tRNA(lys)/RNA primer/template of human immunodeficiency virus.: Arch Biochem Biophys. 1996 Jan 15;325(2):209-16. Unique Identifier : AIDSLINE MED/96139301; Artzi HB; Shemesh J; Zeelon E; Amit B; Kleiman L; Gorecki M; Panet A; Bio-Technology General Israel, Ltd., Kiryat Weizmann, Rehovot,; Israel.; The specificity of the initial cleavage by the RNaseH activity of HIV-1 reverse transcriptase (RT) during minus strong-stop DNA synthesis was studied using the authentic primer/template tRNA(lys)/HIV RNA. We observed that concomitant with the initiation of DNA synthesis, RNaseH activity of HIV RT introduced the first
Use of murine subinoculation for the diagnosis and isolation of toxoplasmosis in HIV-infected patients with persistent lymphadenopathy.: Ann Trop Med Parasitol. 1993 Apr;87(2):179-84. Unique Identifier : AIDSLINE MED/96170905; Diego JA; Vazquez JJ; Penin P; Fernandez J; Sanchez S; Gamallo C; Departamento de Medicina Preventiva y Salud Publica, Facultad de; Medicina (UAM), Madrid, Spain.; A murine model was used to try to elucidate the importance of Toxoplasma gondii infection in HIV-positive patients. Laboratory mice were inoculated with lymph node homogenates or buffy coats from 30 HIV-infected individuals with persistent lymphadenopathy. Sabin and Feldman dye-tests, direct agglutination tests and in
Professional HIV risk taking, levels of victimization, and well-being in female prostitutes in The Netherlands.: Arch Sex Behav. 1995 Oct;24(5):503-15. Unique Identifier : AIDSLINE MED/96119676; Vanwesenbeeck I; de Graaf R; van Zessen G; Straver CJ; Visser JH; Tilburg University, Utrecht, The Netherlands.; Professional HIV risk taking (nonconsistent condom use with clients) of female prostitutes in The Netherlands is addressed within the context of (early) experiences with abuse, well-being, coping behavior, job satisfaction, and financial need. Data were gathered from 127 femal
T cell lymphoma in transgenic mice expressing the human Hsp70 gene.: Biochem Biophys Res Commun. 1996 Jan 17;218(2):582-7. Unique Identifier : AIDSLINE MED/96144719; Seo JS; Park YM; Kim JI; Shim EH; Kim CW; Jang JJ; Kim SH; Lee WH; Transgenic Mice Center, Cancer Research Institute, Seoul, Korea.; In the course of studying the role of hsp70 in the differentiation of pancreatic beta cells, transgenic founder mice were generated with the human hsp70 gene fused to the human insulin gene promoter. One resulted in a transgenic line that consistently developed diabetes mellitus, but unexpectedly three other independe
Do asymptomatic HIV-seropositive individuals show cognitive deficit? [editorial]: AIDS. 1995 Nov;9(11):1211-20. Unique Identifier : AIDSLINE MED/96126174; Newman SP; Lunn S; Harrison MJ
Autocrine interferon-beta synthesis for gene therapy of HIV infection: increased resistance to HIV-1 in lymphocytes from healthy and HIV-infected individuals.: AIDS. 1995 Nov;9(11):1221-8. Unique Identifier : AIDSLINE MED/96126175; Vieillard V; Lauret E; Maguer V; Jacomet C; Rozenbaum W; Gazzolo L; De Maeyer E; URA 1343 Centre National de la Recherche Scientifique, Institut; Curie, University of Paris 11, Orsay, France.; OBJECTIVE: To explore the possibility of gene therapy of HIV infection based on the multiple antiretroviral activities of interferon (IFN)-beta. DESIGN: We introduced into HIV target cells an IFN-beta gene placed under an expression control ensuring a low and constitutive expression, sufficient to confer a permanent a
The gp120 envelope of HIV-1 binds peptides in a similar manner to human leukocyte antigens.: AIDS. 1995 Nov;9(11):1229-35. Unique Identifier : AIDSLINE MED/96126176; Sheikh MJ; Ongradi J; Austen BM; Dalgleish AG; Department of Cellular and Molecular Sciences, St George's; Hospital Medical School, London, UK.; OBJECTIVE: All the conserved regions of HIV gp120 have at least some partial homology with human leukocyte antigen (HLA) class I or class II. One functional similarity is the ability of gp120 and HLA class II to bind CD4. Given the close association between HIV-induced disease and the amount of immune activation and a
HIV-1 Tat modulates invasion by a bacterial enteric pathogen into a human intestinal cell line.: AIDS. 1995 Nov;9(11):1237-42. Unique Identifier : AIDSLINE MED/96126177; Mayer HB; Wanke CA; Du B; Hammer SM; Terwilliger EF; Division of Infectious Diseases, New England Deaconess Hospital,; Boston, MA 02115, USA.; OBJECTIVE: To explore the possibility that an HIV-1 gene product may modulate entry of an invasive enteric pathogen into a terminally differentiated human intestinal cell line. HIV-1 Tat was selected for investigation because of its unique ability to cross cell membranes. METHODS: After transient transfection of HT29-
Early biopsy versus empiric treatment with delayed biopsy of non-responders in suspected HIV-associated cerebral toxoplasmosis: a decision analysis.: AIDS. 1995 Nov;9(11):1243-50. Unique Identifier : AIDSLINE MED/96126178; Mathews C; Barba D; Fullerton SC; Department of Medicine, University of California, San Diego, USA.; OBJECTIVE: To construct and evaluate a decision analytic model of proposed management strategies for HIV-infected patients presenting with cerebral mass lesions, radiographically compatible with toxoplasmosis, lymphoma, or other etiologies, assuming knowledge of Toxoplasma antibody status in serum. METHODS: Using deci
Autopsy-proven causes of death in HIV-infected patients treated for tuberculosis in Abidjan, Cote d'Ivoire.: AIDS. 1995 Nov;9(11):1251-4. Unique Identifier : AIDSLINE MED/96126179; Greenberg AE; Lucas S; Tossou O; Coulibaly IM; Coulibaly D; Kassim S; Ackah A; De Cock KM; Projet RETRO-CI, Abidjan, Cote d'Ivoire.; OBJECTIVE: To determine autopsy-proven causes of death in HIV-infected patients treated for tuberculosis in Abidjan, Cote d Ivoire . METHODS: A computerized listing of 9523 patients diagnosed with tuberculosis and tested for HIV infection at Abidjan s two large tuberculosis tre
Prospective study of high grade anal squamous intraepithelial neoplasia in a cohort of homosexual men: influence of HIV infection, immunosuppression and human papillomavirus infection.: AIDS. 1995 Nov;9(11):1255-62. Unique Identifier : AIDSLINE MED/96126180; Critchlow CW; Surawicz CM; Holmes KK; Kuypers J; Daling JR; Hawes SE; Goldbaum GM; Sayer J; Hurt C; Dunphy C; et al; Department of Epidemiology, School of Public Health and Community; Medicine, University of Washington, Seattle 98195, USA.; OBJECTIVE: To determine the risk of developing high grade anal squamous intraepithelial neoplasia (HG-AIN) in relation to HIV infection and immunosuppression, after controlling for the effects of human papillomavirus (HPV) infection. DESIGN: Prospective cohort study of 158 HIV-seropositive and 147 HIV-seronegative hom
Modelling the impact of alternative HIV intervention strategies in rural Uganda.: AIDS. 1995 Nov;9(11):1263-70. Unique Identifier : AIDSLINE MED/96126181; Robinson NJ; Mulder DW; Auvert B; Hayes RJ; INSERM Unit 88, National Hospital of Saint-Maurice, France.; OBJECTIVE: To assess the likely impact on HIV incidence of increased condom use, a reduction in casual sexual partners, treatment programmes for other sexually transmitted diseases (STD) and combinations of these in rural Uganda . METHODS: A simulation model for the transmission dyn
A randomized trial of an education and support program for HIV-infected individuals.: AIDS. 1995 Nov;9(11):1271-8. Unique Identifier : AIDSLINE MED/96126182; Cleary PD; Van Devanter N; Steilen M; Stuart A; Shipton-Levy R; McMullen W; Rogers TF; Singer E; Avorn J; Pindyck J; Department of Health Care Policy, Harvard Medical School, Boston,; Massachusetts 02115, USA.; OBJECTIVES: To assess the effectiveness of an intervention for providing information and support to HIV-positive donors on changes in their sexual behavior, and to assess which donor characteristics are predictive of behavior change. DESIGN: Subjects were randomly assigned to a structured intervention or community ref
Acceptability of HIV vaccine trials in high-risk heterosexual cohorts in Mombasa, Kenya.: AIDS. 1995 Nov;9(11):1279-83. Unique Identifier : AIDSLINE MED/96126183; Jackson DJ; Martin HL Jr; Bwayo JJ; Nyange PM; Rakwar JP; Kashonga F; Mandaliya K; Ndinya-Achola JO; Kreiss JK; Department of Epidemiology, University of Washington, Seattle; 98104-2499, USA.; OBJECTIVES: To ascertain the level of acceptance of a prophylactic HIV vaccine trial in high-risk HIV-seronegative heterosexual cohorts of men and women in Mombasa, Kenya , and to assess the anticipated effects of participation on risk behavior. METHODS: Standardized questionnaire ad
Tolerance of a triple combination therapy with zidovudine, didanosine and interferon-alpha in seven HIV-infected patients [letter]: AIDS. 1995 Nov;9(11):1285. Unique Identifier : AIDSLINE MED/96126184; Bissuel F; Trabaud MA; Leriche K; Cotte L; Schlienger I; Rougier P; Trepo C
Weekly fluconazole for the suppression of recurrent thrush in HIV-seropositive patients: impact on the incidence of disseminated cryptococcal infection [letter]: AIDS. 1995 Nov;9(11):1286-7. Unique Identifier : AIDSLINE MED/96126185; Newton JA Jr; Tasker SA; Bone WD; Oldfield EC 3rd; Olson PE; Nguyen MT; Wallace MR
Cluster of HIV-2 infections among older male bisexuals in Gipuzkoa, Basque Country, Spain [letter]: AIDS. 1995 Nov;9(11):1287-8. Unique Identifier : AIDSLINE MED/96126186; Perez-Trallero E; de la Puente E; Cilla G
Serum and saliva immunoglobulin A concentrations show an inverse relationship in HIV infection and AIDS [letter]: AIDS. 1995 Nov;9(11):1288-9. Unique Identifier : AIDSLINE MED/96126187; Sweet SP; Rahman D; Challacombe SJ
Tuberculin reaction size in patients infected with HIV [letter]: AIDS. 1995 Nov;9(11):1289-90. Unique Identifier : AIDSLINE MED/96126188; Moreno S; Baraia-Etxaburu J; Miralles P; Berenguer J; Cosin J; Bernaldo de Qurios JC
Hydroxyurea and HIV-1 viraemia [letter]: AIDS. 1995 Nov;9(11):1290-1. Unique Identifier : AIDSLINE MED/96126189; Lafeuillade A; Pellegrino P; Poggi C; Profizi N; Thiebaut C
Risk factors and patterns of HIV-1 transmission in the El Salvador military during war time [letter]: AIDS. 1995 Nov;9(11):1291-2. Unique Identifier : AIDSLINE MED/96126190; Wollants E; Schoenenberg M; Figueroa C; Shor-Posner G; Klaskala W; Baum MK
Smoking marijuana before sex: a high-risk behavior in Jamaica? [letter]: AIDS. 1995 Nov;9(11):1293-4. Unique Identifier : AIDSLINE MED/96126191; Simeon DT; Bain BC; Wyatt GE; Le Franc E; Ricketts H; Chambers C; Tucker MB
Retrospective versus prospective estimates of number of sexual partners [letter]: AIDS. 1995 Nov;9(11):1294-5. Unique Identifier : AIDSLINE MED/96126192; Feldblum PJ; Weir SS
Sex hormones as a cofactor in the pathogenesis of epidemic Kaposi's sarcoma [letter]: AIDS. 1995 Nov;9(11):1295-6. Unique Identifier : AIDSLINE MED/96126193; Klauke S; Schoefer H; Althoff PH; Michels B; Helm EB
Statistics from the World Health Organization.: AIDS. 1995 Nov;9(11):1297-8. Unique Identifier : AIDSLINE MED/96126194
Collaborative AIDS prevention research in the developing world: the CAPS experience.: AIDS. 1995 Jul;9 Suppl 1:S1-5. Unique Identifier : AIDSLINE MED/96085737; Hearst N; Mandel JS; Coates TJ; Center for AIDS Prevention Studies (CAPS), University of; California, San Francisco 94143, USA.; BACKGROUND: Prevention through behavior change is the only way to control the spread of HIV infection in the developing world. Success in prevention requires consistent and persistent intervention over time, a clear understanding of the realities of target populations and involvement of members of these populations in
AIDS prevention research in the developing world.: AIDS. 1995 Jul;9 Suppl 1:S1-77. Unique Identifier : AIDSLINE MED/96171457
Female partners of AIDS patients in Uganda: reported knowledge, perceptions and plans.: AIDS. 1995 Jul;9 Suppl 1:S15-9. Unique Identifier : AIDSLINE MED/96085739; Baingana G; Choi KH; Barrett DC; Byansi R; Hearst N; Department of Medicine, New Mulago Hospital, Kampala, Uganda.; OBJECTIVE: To assess reported knowledge of a partner s AIDS diagnosis, perceived risk of HIV infection, need for HIV testing and future support plans among women partners of male Ugandan AIDS patients. SUBJECTS AND METHODS: A cross-sectional descriptive survey was conducted at New Mulago Hospital, Kampala, Uganda. The
Impact of an intervention on HIV, sexually transmitted diseases, and condom use among sex workers in Bombay, India.: AIDS. 1995 Jul;9 Suppl 1:S21-30. Unique Identifier : AIDSLINE MED/96085740; Bhave G; Lindan CP; Hudes ES; Desai S; Wagle U; Tripathi SP; Mandel JS; AIDS Surveillance Center, Department of Microbiology, Seth G.S.; Medical College, Bombay, India.; OBJECTIVE: To develop and test an HIV intervention targeting sex workers and madams in the brothels of Bombay. SUBJECTS AND METHODS: In a controlled intervention trial, with measurements before and after the intervention, 334 sex workers and 20 madams were recruited from an intervention site, and 207 and 17, respectiv
Socioeconomic status and risk of HIV-1, syphilis and hepatitis B infection among sex workers in Sao Paulo State, Brazil. Instituto Adolfo Lutz Study Group.: AIDS. 1995 Jul;9 Suppl 1:S31-7. Unique Identifier : AIDSLINE MED/96085741; Lurie P; Fernandes ME; Hughes V; Arevalo EI; Hudes ES; Reingold A; Hearst N; Center for AIDS Prevention Studies (CAPS), University of; California, San Francisco 94105, USA.; OBJECTIVES: To determine how HIV risk behavior and the prevalences of sexually transmitted diseases vary according to socioeconomic status and city among sex workers in Sao Paulo State, Brazil . SUBJECTS AND METHODS: A cross-sectional study of 600 female sex workers (100 of a higher
AIDS risk-taking behavior during carnival in Sao Paulo, Brazil.: AIDS. 1995 Jul;9 Suppl 1:S39-44. Unique Identifier : AIDSLINE MED/96085742; Hughes V; Stall RD; Klouri C; Barrett DC; Arevalo EI; Hearst N; Office of the Secretary of Health, State of Sao Paulo, Brazil.; OBJECTIVE: The Brazilian Carnival is thought to be a time when the risk of HIV infection is likely to be high. We therefore compared the risk during Carnival to risk in the past month among male samba school participants in Sao Paulo, Brazil. SUBJECTS AND METHODS: A cross-sectional study was conducted among 380 male s
A family planning intervention to reduce vertical transmission of HIV in Rwanda.: AIDS. 1995 Jul;9 Suppl 1:S45-51. Unique Identifier : AIDSLINE MED/96085743; King R; Estey J; Allen S; Kegeles S; Wolf W; Valentine C; Serufilira A; Department of Epidemiology and Biostatistics, UCSF, USA.; OBJECTIVES: Since contraception is an effective way of preventing the vertical transmission of HIV, we evaluated the impact of a family planning intervention on hormonal contraceptive use and incident pregnancy in a group of HIV-positive and HIV-negative urban Rwandan women. SUBJECTS AND METHODS: In a longitudinal coh
Adolescent sexuality in Saint Petersburg, Russia.: AIDS. 1995 Jul;9 Suppl 1:S53-60. Unique Identifier : AIDSLINE MED/96085744; Lunin I; Hall TL; Mandel JS; Kay J; Hearst N; Center for AIDS Prevention Studies (CAPS), University of; California, San Francisco 94105, USA.; OBJECTIVES: To describe adolescent knowledge, attitudes and behavior relevant to sexuality and the prevention of AIDS in Saint Petersburg, Russia . SUBJECTS AND METHODS: A cross-sectional descriptive study was designed, taking a random sample of 10th grade students at 14 Saint Peter
'Dry sex' and HIV infection among women attending a sexually transmitted diseases clinic in Lusaka, Zambia.: AIDS. 1995 Jul;9 Suppl 1:S61-8. Unique Identifier : AIDSLINE MED/96085745; Sandala L; Lurie P; Sunkutu MR; Chani EM; Hudes ES; Hearst N; Department of Dermato-Venereology, University Teaching Hospital,; Lusaka, Zambia.; OBJECTIVES: To describe dry sex practices intended to decrease vaginal secretions and to determine whether these practices are related to HIV infection. SUBJECTS AND METHODS: A cross-sectional study was conducted in a sexually transmitted diseases clinic in a teaching hospital in Lusaka,
'Superstar' and 'model brothel': developing and evaluating a condom promotion program for sex establishments in Chiang Mai, Thailand.: AIDS. 1995 Jul;9 Suppl 1:S69-75. Unique Identifier : AIDSLINE MED/96085746; Visrutaratna S; Lindan CP; Sirhorachai A; Mandel JS; Chiang Mai Provincial Public Health Office, Thailand.; OBJECTIVES: We developed and evaluated a multifaceted AIDS prevention program to increase condom use among sex workers in the city of Chiang Mai, Northern Thailand . SUBJECTS AND METHODS: A year-long intervention targeted sex workers, brothel owners and clients, promoted cooperati
Results of a model AIDS prevention program for high school students in the Philippines.: AIDS. 1995 Jul;9 Suppl 1:S7-13. Unique Identifier : AIDSLINE MED/96085738; Aplasca MR; Siegel D; Mandel JS; Santana-Arciaga RT; Paul J; Hudes ES; Monzon OT; Hearst N; Research Institute for Tropical Medicine, Department of Health,; Alabang, Muntinlupa, Metro Manila, Philippines.; OBJECTIVES: To describe the sexual practices of high school students; to describe the process of development of a school-based AIDS prevention program; and to evaluate the effect of this program on students AIDS-related knowledge, attitudes and AIDS-preventive behaviors. SUBJECTS AND METHODS: A cluster-randomized, co
Primary central nervous system lymphoma: treatment with chemotherapy and radiotherapy.: Eur J Cancer. 1995 Nov;31A(12):2003-7. Unique Identifier : AIDSLINE MED/96164933; Sarazin M; Ameri A; Monjour A; Nibio A; Poisson M; Delattre JY; Department of Neurology, Hopital de la Salpetriere, Paris,; France.; Between 1989 and 1993, 22 HIV negative patients with primary central nervous system lymphoma (PCNLS) were treated with three different regimens. In group A, 13 patients received preradiotherapy systemic and intrathecal methotrexate (MTX), radiotherapy (RT) and three courses of post-RT chemotherapy (CT) with thiotepa a
Selenium and cellular immunity. Evidence that selenoproteins may be encoded in the +1 reading frame overlapping the human CD4, CD8, and HLA-DR genes.: Biol Trace Elem Res. 1995 Aug-Sep;49(2-3):85-95. Unique Identifier : AIDSLINE MED/96087332; Taylor EW; Computational Center for Molecular Structure and Design,; University of Georgia, Athens 30602-2352, USA.; Selenium deficiency can lead to impaired immune function and reduced T-cell counts, as well as various specific disorders. Significantly, in ARC and AIDS patients, a progressive decline in plasma Se, paralleling T-cell loss, has been widely documented. Since evidence now suggests that there is an extremely high turnov
Zidovudine therapy in HIV infection: which patients should be treated and when.: Br J Clin Pharmacol. 1995 Aug;40(2):107-10. Unique Identifier : AIDSLINE MED/96020129; Barry MG; Back DJ; Breckenridge AM; Department of Pharmacology and Therapeutics, University of; Liverpool, UK.
A mAb against HLA-A2 can be influenced both positively and negatively by the associated peptide.: Int Immunol. 1995 Oct;7(10):1599-605. Unique Identifier : AIDSLINE MED/96128653; Barouch D; Davenport M; McMichael A; Reay P; Nuffield Department of Clinical Medicine, Institute of Molecular; Medicine, John Radcliffe Hospital, Oxford, UK.; Presentation of peptides by class I HLA molecules is essential for the development of a T cell-mediated immune response. TCRs have the ability to discriminate among large numbers of different HLA-peptide complexes. We have identified a mAb, MA2.1, that also discriminates among HLA-A2 associated with different peptides
Administration of IL-12 during ongoing immune responses fails to permanently suppress and can even enhance the synthesis of antigen-specific IgE.: Int Immunol. 1995 Oct;7(10):1649-57. Unique Identifier : AIDSLINE MED/96128658; Germann T; Guckes S; Bongartz M; Dlugonska H; Schmitt E; Kolbe L; Kolsch E; Podlaski FJ; Gately MK; Rude E; Institut fur Immunologie, Mainz, Germany.; The synthesis of antibodies of the IgE isotype in mice largely depends on IL-4, a cytokine that is released by T lymphocytes of the Th2 subtype. IL-12 is a cytokine considered to direct Th cell development into a Th1 direction and to suppress Th2 responses including the synthesis of IgE. Here we report about the influ
Cross-linking of Fc gamma receptors activates HIV-1 long terminal repeat-driven transcription in human monocytes.: Int Immunol. 1995 Oct;7(10):1665-70. Unique Identifier : AIDSLINE MED/96128660; Tsitsikov EN; Fuleihan R; McIntosh K; Scholl PR; Geha RS; Division of Immunology, Children's Hospital, Boston, MA 02115,; USA.; Elevation of the levels of circulating immune complexes frequently accompanies HIV-1 infection and is a prognostic indicator of clinical progression from asymptomatic infection to AIDS. Here we report that cross-linking of Fc gamma RI or Fc gamma RII by adherent human IgG or by specific anti-Fc gamma R mAb activates H
ICAM-1 is required for T cell proliferation but not for anergy or apoptosis induced by Staphylococcus aureus enterotoxin B in vivo.: Int Immunol. 1995 Oct;7(10):1691-8. Unique Identifier : AIDSLINE MED/96128663; Gonzalo JA; Martinez C; Springer TA; Gutierrez-Ramos JC; Center for Blood Research, Harvard Medical School, Boston, MA; 02115, USA.; The response of T lymphocytes to superantigens requires expression of the appropriate TCR V beta gene products as well as the establishment of cellular interactions mediated by adhesion molecules. To study the role of intercellular adhesion molecule (ICAM)-1 in the response in vivo to superantigens, we have analyzed t
Pigmented conjunctival epithelial dysplasia in an HIV positive African: detection of human papillomavirus type 16 [letter]: Br J Ophthalmol. 1995 Dec;79(12):1138-40. Unique Identifier : AIDSLINE MED/96164902; Loeffler KU; Witschel H; Ikenberg H; Wiegering I; Sundmacher R
Neuroretinitis, aseptic meningitis, and lymphadenitis associated with Bartonella (Rochalimaea) henselae infection in immunocompetent patients and patients infected with human immunodeficiency virus type 1.: Clin Infect Dis. 1995 Aug;21(2):352-60. Unique Identifier : AIDSLINE MED/96002790; Wong MT; Dolan MJ; Lattuada CP Jr; Regnery RL; Garcia ML; Mokulis EC; LaBarre RA; Ascher DP; Delmar JA; Kelly JW; et al; Department of Infectious Diseases/PSMI, Wilford Hall Medical; Center, Lackland Air Force Base, Texas 78236-5300, USA.; Bartonella (Rochalimaea) henselae causes a variety of diseases, including bacillary angiomatosis , peliosis hepatis, lymphadenitis, aseptic meningitis with bacteremia, and cat-scratch disease (CSD). Cases of B. henselae-related disease were collected from September 1991 throug
Clinical spectrum of herpes zoster in adults infected with human immunodeficiency virus.: Clin Infect Dis. 1995 Aug;21(2):370-5. Unique Identifier : AIDSLINE MED/96002792; Glesby MJ; Moore RD; Chaisson RE; Department of Medicine, Johns Hopkins University, School of; Medicine, Baltimore, Maryland 21205, USA.; To determine the incidence and clinical manifestations of herpes zoster in a hospital-based clinic for adults infected with human immunodeficiency virus (HIV), we reviewed the records of all patients for whom zoster was diagnosed at or after their first clinic visit. Fifty-two episodes of zoster occurred in 45 patient
Thrombocytopenia in patients infected with human immunodeficiency virus: treatment update.: Clin Infect Dis. 1995 Aug;21(2):415-23. Unique Identifier : AIDSLINE MED/96002799; Glatt AE; Anand A; Department of Medicine, Catholic Medical Center of Brooklyn and; Queens, Jamaica, New York 11432, USA.; Thrombocytopenia that is associated with infection due to human immunodeficiency virus (HIV) is an important and common hematologic abnormality. Although this condition is often asymptomatic, it may manifest clinically as a spectrum of bleeding problems including petechiae, ecchymoses, epistaxis, or menorrhagia or as
Usefulness of bone marrow examination in the evaluation of unexplained fevers in patients infected with human immunodeficiency virus.: Clin Infect Dis. 1995 Aug;21(2):427-8. Unique Identifier : AIDSLINE MED/96002801; Engels E; Marks PW; Kazanjian P; Department of Medicine, Brigham and Women's Hospital, Boston,; Massachusetts, USA.; The diagnostic usefulness of 69 bone marrow examinations (BMEs) performed for evaluating unexplained fever in 65 persons who were infected with human immunodeficiency virus was retrospectively compared with the usefulness of other diagnostic modalities used to investigate the cause of fever. An etiology for the fever
Clinical course and treatment of adults with severe measles pneumonitis [letter]: Clin Infect Dis. 1995 Aug;21(2):443. Unique Identifier : AIDSLINE MED/96002807; Goetz MB; Mathisen GE
Pasteurella pneumotropica pneumonia in a patient with AIDS [letter]: Clin Infect Dis. 1995 Aug;21(2):445-6. Unique Identifier : AIDSLINE MED/96002809; Cuadrado-Gomez LM; Arranz-Caso JA; Cuadros-Gonzalez J; Albarran-Hernandez F
Primary human immunodeficiency virus infection presenting as myopericarditis and rhabdomyolysis [letter]: Clin Infect Dis. 1995 Aug;21(2):451-2. Unique Identifier : AIDSLINE MED/96002814; Guillaume MP; Van Beers D; Delforge ML; Devriendt J; Cogan E
Toxoplasmosis of the bladder in a patient with AIDS [letter]: Clin Infect Dis. 1995 Aug;21(2):452-4. Unique Identifier : AIDSLINE MED/96002815; Besnier JM; Verdier M; Cotty F; Fetissof F; Besancenez A; Choutet P
The growth of human HIV-1 infected U937 cells in immune-deprived mice.: Biomed Pharmacother. 1995;49(7-8):358-63. Unique Identifier : AIDSLINE MED/96145528; Chernukhin IV; Chepurnov AA; Gaidul KV; Siberian Branch of the Russian Academy of Medical Sciences,; Novosibirsk, Russia.; We report in vivo growth of human promonocytic cells infected with HIV-1 presented in new mouse model. Cloned U937 cells chronically infected with HIV-1 were grafted in (CBA*C57B1/6)F1 mice deprived of immunity by thymectomia and total body irradiation with subsequent marrow reconstitution. Nine weeks after cell inocu
Changes in T-cell subpopulations in mice during prolonged experimental secondary infection with Echinococcus granulosus.: Biosci Rep. 1995 Aug;15(4):201-8. Unique Identifier : AIDSLINE MED/96126621; Rueda MC; Osuna A; De Rycke PH; Janssen D; Laboratorio de Analisis, Hospital Torrecardenas, Almeria,; Spain.; Balb/c mice were infected intraperitoneally with protoscoleces of Echinococcus granulosus. After 15 months of infection, and by means of flow cytometry, the expression of T-cell markers CD3, CD4, and CD8 on T cells from peripheral blood, spleen, and thymus was analyzed and compared with that of age-matched controls. I
A deletion in the proximal untranslated pX region of human T-cell leukemia virus type II decreases viral replication but not infectivity in vivo.: Blood. 1996 Feb 1;87(3):1030-5. Unique Identifier : AIDSLINE MED/96151985; Cockerell GL; Rovnak J; Green PL; Chen IS; Department of Pathology, College of Veterinary Medicine and; Biomedical Sciences, Colorado State University, Fort Collins; 80523-1671, USA.; The function of untranslated (UT) nucleotide sequences in the proximal portion of the pX region of the human T-cell leukemia virus (HTLV) family of retroviruses remains enigmatic. Previous studies have shown that these sequences are not necessary for the expression of viral proteins or for the induction, transmission,
Expression of Epstein-Barr virus-encoded latent membrane protein 1 in nonendemic Burkitt's lymphomas [letter]: Blood. 1996 Feb 1;87(3):1202-4. Unique Identifier : AIDSLINE MED/96152009; Carbone A; Gloghini A; Zagonel V; Tirelli U
Deletion variants within the NF-kappa B activation domain of the LMP1 oncogene prevail in acquired immunodeficiency syndrome-related large cell lymphomas and human immunodeficiency virus-negative atypical lymphoproliferations.: Blood. 1996 Feb 1;87(3):876-81. Unique Identifier : AIDSLINE MED/96151965; Knecht H; Raphael M; McQuain C; Rothenberger S; Pihan G; Camilleri-Broet S; Bachmann E; Kershaw GR; Ryan S; Kittler EL; Quesenberry PJ; Schlaifer D; Woda BA; Brousset P; LINK Laboratories, University of Massachusetts Medical Center,; Worcester 01655-0246, USA.; This sequencing study of 17 acquired immunodeficiency syndrome-related lymphomas (9 primary brain, 8 systemic) and 8 human immunodeficiency virus-negative atypical lymphoproliferations expressing large amounts of the latent membrane protein 1 (LMP1) of Epstein-Barr virus was performed to characterize the carboxy termi
Human immunodeficiency virus infection of bone marrow endothelium reduces induction of stromal hematopoietic growth factors.: Blood. 1996 Feb 1;87(3):919-25. Unique Identifier : AIDSLINE MED/96151972; Moses AV; Williams S; Heneveld ML; Strussenberg J; Rarick M; Loveless M; Bagby G; Nelson JA; Department of Molecular Microbiology, Oregon Health Sciences; University, Portland, USA.; The majority of human immunodeficiency virus (HIV)-seropositive patients develop bone marrow abnormalities associated with hematopoietic malfunction during the progression of disease. One important manifestation of HIV-associated hematopoietic dysfunction is that after myelosuppression, bone marrow recovery, a process
Cytokines in the acquired immunodeficiency syndrome and other infectious diseases.: Int J Clin Lab Res. 1995;25(3):128-34. Unique Identifier : AIDSLINE MED/96121690; Poli G; Vicenzi E; Ghezzi S; Lazzarin A; Department of Infectious Diseases, San Raffaele Hospital and; Scientific Institute, IRCCS, Milan, Italy.; The pathogenesis of several infectious diseases is frequently related not only to their etiological agents of viral, bacterial, or parasitic nature, but also to the host immune response. Both inflammatory responses and specific immune responses to the invading microorganisms are controlled by complex networks of inter
New diagnostic techniques for the detection of opportunistic pathogens involved in pneumonia in immunocompromised hosts [editorial]: Intern Med. 1995 Oct;34(10):933-4. Unique Identifier : AIDSLINE MED/96157619; Oizumi K
More acquired immunodeficiency syndrome (AIDS) dementia complex in Japan? [editorial; comment]: Intern Med. 1995 Oct;34(10):935. Unique Identifier : AIDSLINE MED/96157620; Kanazawa I
Adult T-cell leukemia.: Intern Med. 1995 Oct;34(10):947-52. Unique Identifier : AIDSLINE MED/96157624; Takatsuki K; Second Department of Internal Medicine, Kumamoto University; School of Medicine.; Adult T-cell leukemia (ATL) was first reported in Japan , where it has a high incidence in the southwestern region. The retrovirus, human T-lymphotropic virus type I (HTLV-I), is the causative agent of ATL. In ATL-endemic areas, the rate of HTLV-I carriers is high. A definite diagnos
Varied effects of thoracic irradiation on peripheral lymphocyte subsets in lung cancer patients.: Intern Med. 1995 Oct;34(10):959-65. Unique Identifier : AIDSLINE MED/96157626; Nakayama Y; Makino S; Fukuda Y; Min KY; Ikemoto T; Shimizu A; Ohsawa N; First Department of Internal Medicine, Osaka Medical College,; Takatsuki.; To investigate the influence of thoracic irradiation on immunological competence in patients with lung cancer, we examined the changes in peripheral blood lymphocyte subsets in 15 patients before and after radiation therapy by two-color flow cytometry techniques. After radiation therapy, the percentage and the absolut
Detection of Pneumocystis carinii, Mycobacterium tuberculosis, and cytomegalovirus in human immunodeficiency virus (HIV)-infected patients with hemophilia by polymerase chain reaction of induced sputum samples.: Intern Med. 1995 Oct;34(10):976-81. Unique Identifier : AIDSLINE MED/96157629; Shimomoto H; Hasegawa Y; Takagi N; Ichiyama S; Takamatsu J; Saito H; Shimokata K; First Department of Internal Medicine, Nagoya University School; of Medicine.; The purpose of this study was to diagnose the initial stage of acute pulmonary infections due to Pneumocystis carinii (P. carinii), Mycobacterium tuberculosis (M. tuberculosis), and cytomegalovirus ( CMV ) by polymerase chain r
A hemophiliac with human immunodeficiency virus (HIV)-1-associated dementia complex [see comments]: Intern Med. 1995 Oct;34(10):995-9. Unique Identifier : AIDSLINE MED/96157633; Arimura H; Nakagawa M; Maruyama Y; Arimura K; Osame M; Third Department of Internal Medicine, Faculty of Medicine,; Kagoshima University.; We report a 29-year-old male hemophiliac with human immunodeficiency virus (HIV)-1-associated dementia complex, who died 2.5 months after the onset of dementia. The patient s cognitive abnormalities including forgetfulness, loss of concentration and slowing of thought appeared abou
Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP): recent perspectives.: Intern Med. 1995 Aug;34(8):713-21. Unique Identifier : AIDSLINE MED/96085862; Ijichi S; Osame M; Third Department of Internal Medicine, Faculty of Medicine,; Kagoshima University.; Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a well-defined clinicopathological entity, and approximately 1,900 patients with HAM/TSP have been reported in the world. Improved polymerase chain reaction (PCR)-based in situ techniques have allowed a better ap
Interleukin-2 therapy of Langerhans cell histiocytosis.: Acta Paediatr. 1995 Oct;84(10):1204-6. Unique Identifier : AIDSLINE MED/96157173; Hirose M; Saito S; Yoshimoto T; Kuroda Y; Department of Pediatrics, Tokushima University School of; Medicine, Japan.; A 20-month-old girl was diagnosed with Langerhans cell histiocytosis on the basis of a seborrheic skin rash, multiple punched out bony lesions, and skin biopsy findings. Combination therapy including alpha-interferon, vincristine, vindesine, cyclophosphamide, etoposide, cisplatin, betamethasone, THP-adriamycin, cytara
A web-based architecture for a medical vocabulary server.: Proc Annu Symp Comput Appl Med Care. 1995;:275-9. Unique Identifier : AIDSLINE MED/96123727; Gennari JH; Oliver DE; Pratt W; Rice J; Musen MA; Section on Medical Informatics, Knowledge Systems Laboratory,; Stanford University, CA 94305-5479, USA.; For health care providers to share computing resources and medical application programs across different sites, those applications must share a common medical vocabulary. To construct a common vocabulary, researchers must have an architecture that supports collaborative, networked development. In this paper, we presen
A comparison of the temporal expressiveness of three database query methods.: Proc Annu Symp Comput Appl Med Care. 1995;:331-7. Unique Identifier : AIDSLINE MED/96123738; Das AK; Musen MA; Section on Medical Informatics, Stanford University School of; Medicine, California 94305-5479, USA.; Time is a multifaceted phenomenon that developers of clinical decision-support systems can model at various levels of complexity. An unresolved issue for the design of clinical databases is whether the underlying data model should support interval semantics. In this paper, we examine whether interval-based operations
A comparison of two computer-based prognostic systems for AIDS.: Proc Annu Symp Comput Appl Med Care. 1995;:737-41. Unique Identifier : AIDSLINE MED/96123820; Ohno-Machado L; Musen MA; Section on Medical Informatics, Stanford University School of; Medicine, CA 94305, USA.; We compare the performances of a Cox model and a neural network model that are used as prognostic tools for a cohort of people living with AIDS. We modeled disease progression for patients who had AIDS (according to the 1993 CDC definition) in a cohort of 588 patients in California, using data from the ATHOS project.
[Coagulase-negative staphylococci in normal and chronically inflamed conjunctiva]: Ophthalmologe. 1995 Dec;92(6):793-801. Unique Identifier : AIDSLINE MED/96147371; Grasbon T; Mino de Kaspar H; Klauss V; Augenklinik, Universitat M nchen.; This study examines the prevalence of coagulase-negative Staphylococcus species in normal and mildly inflamed conjunctiva, their sensitivity to antibiotics, and their relationship to the remaining flora. PATIENTS AND METHODS: In 99 patients including 9 HIV-positives in an early stage of the infection, 100 conjunctival
[Selective inhibition of replication of human cytomegalovirus by desferrioxamine in vitro and in vivo (case report)]: Ophthalmologe. 1995 Dec;92(6):840-3. Unique Identifier : AIDSLINE MED/96147378; Gumbel H; Cinatl J Jr; Rabenau H; Vogel JU; Doerr HW; Ohrloff C; Zentrum der Augenheilkunde, Universitat Frankfurt/Main.; In AIDS patients cytomegalovirus (HCMV) retinitis is one of the most frequent opportunistic infections. Antiviral therapy aims at preserving vision as long as possible, but more and more HCMV isolates are proving to be resistant to ganciclovir (GCV) and foscarnet (PFA) in vitro. We
Assignment and modeling of the Rev Response Element RNA bound to a Rev peptide using 13C-heteronuclear NMR.: J Biomol NMR. 1995 Dec;6(4):375-89. Unique Identifier : AIDSLINE MED/96141450; Battiste JL; Tan R; Frankel AD; Williamson JR; Department of Chemistry, Massachusetts Institute of Technology,; Cambridge 02139, USA.; The Rev Response Element (RRE) RNA-Rev protein interaction is important for regulation of gene expression in the human immunodeficiency virus. A model system for this interaction, which includes stem IIB of the RRE RNA and an arginine-rich peptide from the RNA-binding domain of Rev, was studied using multidimensional
Morphological studies on avian spinal cord chimeras.: Int Arch Allergy Immunol. 1996 Feb;109(2):116-26. Unique Identifier : AIDSLINE MED/96162072; Saito K; Sugisaki T; Yang G; Milgrom F; Albini B; Department of Microbiology, State University of New York at; Buffalo 14214, USA.; Spinal cord chimeras were constructed by orthotopic grafting of quail embryonal neutral folds, neural crest and neural tube into chicken embryos. The spinal cord xenografts were accepted for varying lengths of time, but most chimeras eventually rejected the quail transplant. This was associated with perivenular cuffin
Contract minimum dataset includes confidential data [letter]: BMJ. 1996 Jan 20;312(7024):185. Unique Identifier : AIDSLINE MED/96152052; Goodyear OM
Comparison of immunodeficiency and AIDS defining conditions in HIV negative and HIV positive men with haemophilia A [see comments]: BMJ. 1996 Jan 27;312(7025):207-10. Unique Identifier : AIDSLINE MED/96160276; Sabin CA; Pasi KJ; Phillips AN; Lilley P; Bofill M; Lee CA; Department of Public Health, Royal Free Hospital School of; Medicine, London.; OBJECTIVE--To investigate the hypothesis that high usage of clotting factor concentrate, rather than HIV infection, is the cause of immunodeficiency and AIDS in men with haemophilia. DESIGN--A comparison of AIDS defining conditions and CD4 counts in HIV positive and HIV negative patients with haemophilia matched for u
Commentary: non-HIV hypotheses must be studied more carefully [comment]: BMJ. 1996 Jan 27;312(7025):210-1. Unique Identifier : AIDSLINE MED/96160277; Duesberg P; Department of Molecular and Cell Biology, University of; California, Berkeley 94720-3206, USA.
Response: arguments contradict the foreign protein-zidovudine hypothesis.: BMJ. 1996 Jan 27;312(7025):211-2. Unique Identifier : AIDSLINE MED/96160278; Sabin CA; Phillips AN; Lee CA; Department of Public Health, Royal Free Hospital School of; Medicine, London.
Characterization of Encephalitozoon (Septata) intestinalis isolates cultured from nasal mucosa and bronchoalveolar lavage fluids of two AIDS patients.: J Eukaryot Microbiol. 1996 Jan-Feb;43(1):34-43. Unique Identifier : AIDSLINE MED/96151459; Didier ES; Rogers LB; Orenstein JM; Baker MD; Vossbrinck CR; Van Gool T; Hartskeerl R; Soave R; Beaudet LM; Department of Microbiology, Tulane Regional Primate Research; Center, Covington, Louisiana 70433, USA.; Microsporidia are obligate intracellular protozoan parasites that can cause opportunistic infections in AIDS patients. Species from five genera of microsporidia are presently known to infect man. One species, Septata intestinalis originally was detected in stool specimens of individuals with chronic diarrhea and subse
Comparative development of two microsporidian species: Enterocytozoon bieneusi and Enterocytozoon salmonis, reported in AIDS patients and salmonid fish, respectively.: J Eukaryot Microbiol. 1996 Jan-Feb;43(1):49-60. Unique Identifier : AIDSLINE MED/96151460; Desportes-Livage I; Chilmonczyk S; Hedrick R; Ombrouck C; Monge D; Maiga I; Gentilini M; Inserm U. 313, Complexe Hospitalier Universitaire; Pitie-Salpetriere, Paris, France.; Enterocytozoon bieneusi and Enterocytozoon salmonis are reported in HIV-infected patients and in salmonid fish, respectively. Both species share the early development of the extrusion apparatus of the spores, which is completed prior to fission of the sporogonic syncytium into sporoblasts, and the early synthesis of p
Illness and compassion: AIDS in an American Zen community.: Camb Q Healthc Ethics. 1995 Fall;4(4):488-93. Unique Identifier : AIDSLINE MED/96126809; Nakasone RY
Can communities protect autonomy? Ethical dilemmas in HIV preventative drug trials.: Camb Q Healthc Ethics. 1995 Fall;4(4):516-23. Unique Identifier : AIDSLINE MED/96126812; Zion D; Centre for Human Bioethics, Monash University, Victoria,; Australia.
HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons.: Eur J Neurosci. 1995 Nov 1;7(11):2285-93. Unique Identifier : AIDSLINE MED/96149639; Lannuzel A; Lledo PM; Lamghitnia HO; Vincent JD; Tardieu M; Laboratoire de Neurovirologie et Neuroimmunologie, UFR; Kremlin-Bicetre, Universite Paris XI, Le Kremlin-Bicetre,; France.; The envelope glycoprotein gp120 of the human immunodeficiency virus HIV-1 has been proposed to cause neuron death in developing murine hippocampal cultures and rat retinal ganglion cells. In the present study, cultured human embryonic cerebral and spinal neurons from 8- to 10-week-old embryos were used to study the ne
Inflammatory and T-cell profile of asthmatic airways 6 hours after local allergen provocation.: Am J Respir Crit Care Med. 1996 Feb;153(2):515-20. Unique Identifier : AIDSLINE MED/96160556; Gratziou C; Carroll M; Montefort S; Teran L; Howarth PH; Holgate ST; University Medicine, Southampton General Hospital, United; Kingdom.; T cells in the airways are considered to play a key role in orchestrating the inflammatory response of asthma through the elaboration of specific cytokines. Using flow cytometry we have investigated the T-cell response of sensitized asthmatic airways 6 h after local allergen provocation. Twelve subjects with atopic as
Increased release of interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha by bronchoalveolar cells lavaged from involved sites in pulmonary tuberculosis.: Am J Respir Crit Care Med. 1996 Feb;153(2):799-804. Unique Identifier : AIDSLINE MED/96160601; Law K; Weiden M; Harkin T; Tchou-Wong K; Chi C; Rom WN; Department of Medicine, New York University Medical Center, New; York 10016, USA.; Mycobacterium tuberculosis and its components have been shown to stimulate mononuclear phagocytes in vitro to release interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6). Animal models of tuberculosis (TB) also demonstrate the presence of cytokines in granulomas. We hypoth
Independent origin of mono-rifampin-resistant Mycobacterium tuberculosis in patients with AIDS.: Am J Respir Crit Care Med. 1996 Feb;153(2):837-40. Unique Identifier : AIDSLINE MED/96160606; Lutfey M; Della-Latta P; Kapur V; Palumbo LA; Gurner D; Stotzky G; Brudney K; Dobkin J; Moss A; Musser JM; Kreiswirth BN; Tuberculosis Center, Public Health Research Institute, Columbia; Presbyterian Medical Center, New York, New York 10016, USA.; Historically, infections caused by Mycobacterium tuberculosis have been treated simultaneously with isoniazid and rifampin. As a consequence of this combined therapy, strains resistant only to rifampin were rarely recovered. However, recently there has been an increasing number of reports describing HIV-positive patie
Cryptococcal meningitis.: Br J Hosp Med. 1995 Nov 1-14;54(9):439-45. Unique Identifier : AIDSLINE MED/96154524; Jones GA; Nathwani D; Infection and Immunodeficiency Unit, Dundee Teaching Hospitals; NHS Trust, Kings Cross Hospital, Dundee.; Fungal meningitis caused by the yeast Cryptococcus neoformans is most commonly seen in patients with defective T-lymphocyte function. This article focuses on the clinical presentation, diagnosis and management of patients with cryptococcal meningitis, in the setting of AIDS and other immunocompromised hosts, and in n
Long-term survivors of HIV-1 infection.: Trends Microbiol. 1995 Oct;3(10):386-91. Unique Identifier : AIDSLINE MED/96124456; Klein MR; Miedema F; Dept of Clinical Viro-immunology, Central Laboratory of The; Netherlands, Red Cross Blood Transfusion Service, Amsterdam, The; Netherlands.; The clinical course and outcome of HIV-1 infection are highly variable. A full spectrum of pathology has been observed, from rapid progression to AIDS within months of HIV-1 seroconversion, to asymptomatic survival for more than a decade. This phenomenon probably reflects the multiphasic and multifactorial nature of t
Anti-AIDS agents--XIX. Neotripterifordin, a novel anti-HIV principle from Tripterygium wilfordii: isolation and structural elucidation.: Bioorg Med Chem. 1995 Oct;3(10):1345-8. Unique Identifier : AIDSLINE MED/96120454; Chen K; Shi Q; Fujioka T; Nakano T; Hu CQ; Jin JQ; Kilkuskie RE; Lee KH; Natural Products Laboratory, School of Pharmacy, University of; North Carolina, Chapel Hill 27599, USA.; A new kaurane type diterpene lactone, neotripterifordin (1), has been isolated from the roots of Tripterygium wilfordii. The structure of 1 was elucidated by spectroscopic methods, which included the concerted application of a number of 2-D NMR techniques including 1H-1H COSY, phase-sensitive NOESY, HETCOR, and long-r
Synthesis and antiviral effects of 2-heteroaryl substituted adenosine and 8-heteroaryl substituted guanosine derivatives.: Bioorg Med Chem. 1995 Oct;3(10):1377-82. Unique Identifier : AIDSLINE MED/96120458; Persson T; Gronowitz S; Hornfeldt AB; Johansson NG; Chemical Center, Lund, Sweden.; 2-(2- and 3-Thienyl)adenosine and the corresponding furyl derivatives were prepared though Pd(0)-catalyzed coupling of 2 ,3 ,5 -tri-O-(t-butyldimethylsilyl)-2-iodoadenosine with the appropriate tributyltin derivatives followed by deprotection. Preparation of the 8-(2- and 3-thienyl)guanosines and 8-(2- and 3-furyl)gua
Stereoselective synthesis, chemistry and antiviral evaluation of 1-(2,3-dideoxy-3-C-hydroxymethyl-beta-D-threo-pentofuranosyl)thym- ine derivatives.: Bioorg Med Chem. 1995 Sep;3(9):1223-9. Unique Identifier : AIDSLINE MED/96103865; Wengel J; Schinazi RF; Caruthers MH; Department of Chemistry and Biochemistry, University of Colorado,; Boulder 80309-0215, USA.; A series of novel 3 -C-branched 2 ,3 -dideoxynucleosides have been synthesized and evaluated as anti-HIV agents. Hydroboration of 2 ,3 -dideoxy-3 -C-methylene nucleoside proceeded regio- and stereoselectively to give 1-(2,3-dideoxy-3-C-hydroxy methyl-5-O-trityl-beta-D-threo-pentofuranosyl)thymine (5) after oxidation.
Comprehensive guidelines on HIV-related opportunistic infections released [news]: Am J Health Syst Pharm. 1995 Oct 15;52(20):2166, 2170. Unique Identifier : AIDSLINE MED/96119404
Treatment during primary HIV infection shows promise [news]: Am J Health Syst Pharm. 1995 Nov 1;52(21):2383-4. Unique Identifier : AIDSLINE MED/96126258
New report validates needle-exchange programs. Programs slow spread of HIV without encouraging drug abuse [news]: Am J Health Syst Pharm. 1995 Nov 1;52(21):2384-6. Unique Identifier : AIDSLINE MED/96126259
Home infusion of antimicrobials as an option for patients with AIDS [letter]: Am J Health Syst Pharm. 1995 Nov 1;52(21):2467-8. Unique Identifier : AIDSLINE MED/96126275; Laing RB; Morgan R; Leen CL
MR imaging of soft-tissue infection.: Magn Reson Imaging Clin N Am. 1995 Nov;3(4):743-51. Unique Identifier : AIDSLINE MED/96157871; Beltran J; Department of Radiology, Hospital for Joint Diseases, New York,; New York, USA.; MR imaging is the ideal technique to display the soft-tissue abnormalities produced by infectious processes. In general these soft-tissue alterations consist of signal intensity changes that reflect the increased water content of the soft tissues induced by the inflammatory reactions. In some cases these changes are n
Inhibition of human immunodeficiency virus type 1 multiplication by transforming growth factor beta 1 and AZT in HIV-1-infected myeloid cells.: J Interferon Cytokine Res. 1995 Oct;15(10):849-55. Unique Identifier : AIDSLINE MED/96122471; McKiel V; Gu Z; Wainberg MA; Hiscott J; Lady Davis Institute for Medical Research, Jewish General; Hospital, Department of Microbiology and Immunology, Montreal,; Quebec, Canada.; Myeloid cells are important reservoirs of HIV-1 infection. In response to pathogenic agents, macrophages secrete inflammatory cytokines that can modulate viral replication and contribute to AIDS pathogenesis. Because HIV replication is dependent on cellular activation, immunosuppressive cytokines that deactivate macro
Bee venom immunotherapy induces a shift in cytokine responses from a TH-2 to a TH-1 dominant pattern: comparison of rush and conventional immunotherapy.: Clin Exp Allergy. 1995 Sep;25(9):828-38. Unique Identifier : AIDSLINE MED/96105566; McHugh SM; Deighton J; Stewart AG; Lachmann PJ; Ewan PW; Molecular Immunopathology Unit, Medical Research Centre,; Cambridge, UK.; BACKGROUND: The mechanism of immunotherapy is unclear. Allergic disease is known to involve enhanced TH-2 cytokine responses to allergen. OBJECTIVE: In order to investigate the mechanisms of immunotherapy, we have examined changes in cytokine secretion before (13 patients) and during (nine patients) both rush and conv
Baboon bone marrow transplanted to AIDS patient [news]: Nat Med. 1996 Jan;2(1):17. Unique Identifier : AIDSLINE MED/96135152; Steele FR
Xenotransplantation at a crossroads: prevention versus progress.: Nat Med. 1996 Jan;2(1):18-21. Unique Identifier : AIDSLINE MED/96135153; Allan JS; Department of Virology and Immunology, Southwest Foundation for; Biomedical Research, San Antonio, Texas 78228, USA.; The infectious disease risks associated with baboon-to-human transplants may represent an insurmountable hurdle in the race to save lives. Yet, public health agencies are reluctant to regulate xenotransplantation in spite of those risks.
Generation of human T lymphocytes from bone marrow CD34+ cells in vitro.: Nat Med. 1996 Jan;2(1):46-51. Unique Identifier : AIDSLINE MED/96135164; Freedman AR; Zhu H; Levine JD; Kalams S; Scadden DT; Division of Hematology/Oncology, New England Deaconess Hospital,; Harvard Medical School, Boston, Massachusetts 02129, USA.; Analysis of the events that regulate development of red blood cells or granulocytes has led to therapies altering clinical conditions associated with anemia or neutropenia. The development of therapeutic approaches to target conditions associated with lymphopenia, such as AIDS, has been thwarted by limited techniques
HIV summit is a good show [news]: Nat Med. 1996 Jan;2(1):9. Unique Identifier : AIDSLINE MED/96135151; Steele FR
Access to adult liver transplantation in Canada: a survey and ethical analysis.: Can Med Assoc J. 1996 Feb 1;154(3):337-42. Unique Identifier : AIDSLINE MED/96164731; Mullen MA; Kohut N; Sam M; Blendis L; Singer PA; University of Toronto Joint Centre for Bioethics, Ont.; OBJECTIVES: To describe the substantive and procedural criteria used for placing patients on the waiting list for liver transplantation and for allocating available livers to patients on the waiting list; to identify principal decision-makers and the main factors limiting liver transplantation in
The use of oral ganciclovir in the treatment of cytomegalovirus retinitis in patients with AIDS.: Can Med Assoc J. 1996 Feb 1;154(3):363-8. Unique Identifier : AIDSLINE MED/96164734; Ward-Able C; Phillips P; Tsoukas CM; BioMed Business Unit of Hoffmann-La Roche (Canada), Mississauga,; Ont.; OBJECTIVE: To recommend the appropriate use of oral ganciclovir as an alternative to intravenous (i.v.) maintenance therapy for cytomegalovirus ( CMV ) retinitis in patients with AIDS. OPTIONS: i.v. infusion of ganciclovir and
45,000 may have been infected with HIV [news]: Can Med Assoc J. 1996 Feb 1;154(3):372. Unique Identifier : AIDSLINE MED/96164735
Concerns of patients, MDs are transforming transfusion medicine.: Can Med Assoc J. 1996 Feb 1;154(3):391-6. Unique Identifier : AIDSLINE MED/96164740; Robb N; Fear of HIV and AIDS has been the driving force in reducing physicians use of blood and blood products. Nancy Robb interviewed doctors across the country to determine steps they are taking to lower the number of transfusions and discovered that transfusion medicine in Canada has u
Symptomatic management of HIV associated gastrointestinal disease.: Cancer Surv. 1994;21:157-77. Unique Identifier : AIDSLINE MED/96157336; McGowan I; Allason-Jones E; Department of Gastroenterology, Radcliffe Infirmary, Oxford.; This chapter describes the differential diagnosis and management of gastrointestinal symptoms associated with HIV infection. There is no clear point when management moves from intervention to palliation, and as with other manifestations of HIV disease, clinical decisions have to be guided by the wishes of the patient.
Hydroxychloroquine treatment of patients with human immunodeficiency virus type 1.: Clin Ther. 1995 Jul-Aug;17(4):622-36. Unique Identifier : AIDSLINE MED/96098329; Sperber K; Louie M; Kraus T; Proner J; Sapira E; Lin S; Stecher V; Mayer L; Division of Clinical Immunology, Mount Sinai Medical Center, New; York, New York, USA.; Hydroxychloroquine (HCQ), an antimalarial agent used to treat patients with autoimmune diseases, has been shown to suppress human immunodeficiency virus type 1 (HIV-1) replication in vitro in T cells and monocytes by inhibiting posttranscriptional modification of the virus. These in vitro observations have been expand
AIDS and the contact lens practice.: CLAO J. 1995 Oct;21(4):233-5. Unique Identifier : AIDSLINE MED/96120756; Slonim CB; Department of Ophthalmology, University of South Florida, College; of Medicine, Tampa 33613, USA.; The probability of the ophthalmologist and office personnel coming into direct contact with a patient infected with the human immunodeficiency virus (HIV) is extremely high. HIV has been recovered from the ocular tissues, tears, and soft contact lenses of patients with acquired immunodeficiency syndrome. All ophthalmi
Cross-reactive antibodies between HIV-gp120 and platelet gpIIIa (CD61) in HIV-related immune thrombocytopenic purpura.: Clin Exp Immunol. 1996 Jan;103(1):19-23. Unique Identifier : AIDSLINE MED/96150276; Bettaieb A; Oksenhendler E; Duedari N; Bierling P; Laboratoire d'Immunologie Leuco-Plaquettaire, Centre de; Transfusion, Creteil, France.; We have previously demonstrated that immune platelet destruction observed in an AIDS-free HIV-infected patient was associated with the presence of a cross-reactive antibody recognizing both HIV-glycoprotein (gp)120 and platelet gpIIIa (CD61). We have now investigated the presence of such antibodies in other HIV-infect
Mitogenic effect of HIV-infected human T cell lines on mouse B cells mediated by surface immunoglobulin.: Clin Exp Immunol. 1996 Jan;103(1):24-9. Unique Identifier : AIDSLINE MED/96150277; Arase N; Arase H; Ohki K; Nishino Y; Ikuta K; Onoe K; Section of Pathology, Hokkaido University, Sapporo, Japan.; Following HIV-1 infection, a number of disorders are induced in both normal T and B cells by virus products derived from infected CD4+ T cells. In the present study, we found that HIV-infected, but not uninfected, human T cell lines generated vigorous blastogenesis and proliferation of freshly isolated mouse B cells i
Generalized immune activation in pulmonary tuberculosis: co-activation with HIV infection.: Clin Exp Immunol. 1996 Jan;103(1):30-4. Unique Identifier : AIDSLINE MED/96150278; Vanham G; Edmonds K; Qing L; Hom D; Toossi Z; Jones B; Daley CL; Huebner B; Kestens L; Gigase P; Ellner JJ; Department of Infection and Immunity, Institute of Tropical; Medicine, Antwerpen, Belgium.; Parameters of immune activation/differentiation were studied in a group of newly diagnosed HIV- and HIV+ pulmonary tuberculosis (TB) patients. Compared with controls, HLA-DR expression on both CD4 and CD8 T cells from the HIV- TB patients was approximately doubled; HLA-DR on T cells from the HIV+ group was tripled. Th
Prevalence of hepatitis C in patients with primary antibody deficiency.: Clin Exp Immunol. 1996 Jan;103(1):5-7. Unique Identifier : AIDSLINE MED/96150273; Webster AD; Brown D; Franz A; Dusheiko G; Department of Clinical Immunology, Royal Free Hospital, London,; UK.; Concern over sporadic hepatitis C virus (HCV) infection from treatment with contaminated immunoglobulin in patients with immunodeficiency prompted use to screen serum from 44 patients for HCV RNA. We found no evidence of either horizontal or iatrogenic infection in our Clinic, except in two patients known to have rece
Gamma delta T lymphocyte responses to HIV.: Clin Exp Immunol. 1996 Feb;103(2):177-84. Unique Identifier : AIDSLINE MED/96152662; Wallace M; Bartz SR; Chang WL; Mackenzie DA; Pauza CD; Malkovsky M; Department of Medical Microbiology and Immunology, University of; Wisconsin Medical School, Madison, USA.; Natural immunity may be involved in controlling viral spread in hosts infected with HIV. A panel of gamma delta T cell receptor-positive lymphocyte clones was isolated from the peripheral blood of healthy HIV- donors and tested for anti-HIV cytotoxic responses. Twelve of 30 (40%) V gamma 9+/V delta 2+ T cell clones, b
Differential maturation of avidity of IgG antibodies to gp41, p24 and p17 following infection with HIV-1.: Clin Exp Immunol. 1996 Feb;103(2):185-91. Unique Identifier : AIDSLINE MED/96152663; Thomas HI; Wilson S; O'Toole CM; Lister CM; Saeed AM; Watkins RP; Morgan-Capner P; Department of Virology, Royal Preston Hospital, UK.; We have evaluated solid-phase ELISA IgG antibody avidity studies as a means of identifying cases of recent HIV-1 infection. Although separate studies on the avidity of anti-gp41 and anti-p24 antibodies in seroconvertors have been reported, a comparison of the ability of patients to simultaneously mature their immune r
Interferon-gamma (IFN-gamma) treatment decreases the inflammatory response in chronic Pseudomonas aeruginosa pneumonia in rats.: Clin Exp Immunol. 1996 Feb;103(2):212-8. Unique Identifier : AIDSLINE MED/96152667; Johansen HK; Hougen HP; Rygaard J; Hoiby N; Department of Clinical Microbiology, Rigshospitalet, Copenhagen,; Denmark.; In a rat model of chronic Pseudomonas aeruginosa lung infection mimicking cystic fibrosis (CF), we studied whether the inflammatory response could be altered by intraperitoneal treatment with recombinant rat interferon-gamma (rrIFN-gamma). Rats were treated either before or after intratracheal challenge with P. aerugi
Administration of anti-CD3 monoclonal antibody during experimental Chagas' disease induces CD8+ cell-dependent lethal shock.: Clin Exp Immunol. 1996 Feb;103(2):233-8. Unique Identifier : AIDSLINE MED/96152670; Jacobs F; Dubois C; Carlier Y; Goldman M; Laboratoire Pluridisciplinaire de Recherche Experimentale; Biomedicale, Hopital Erasme, Brussels, Belgium.; The injection of the 145-2C11 anti-CD3 MoAb in mice induces a polyclonal T cell activation resulting in the release of several cytokines, including interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha). As these cytokines are known to be involved in the host defence against Trypanosoma cruzi, we me
Immune dysregulation in Ethiopian immigrants in Israel: relevance to helminth infections?: Clin Exp Immunol. 1996 Feb;103(2):239-43. Unique Identifier : AIDSLINE MED/96152671; Bentwich Z; Weisman Z; Moroz C; Bar-Yehuda S; Kalinkovich A; R. Ben-Ari Institute of Clinical Immunology, Kaplan Hospital,; Hebrew University Hadassah Medical School, Rehovot, Israel.; The infectious disease background and particularly the helminth infections that are endemic in Africa could have profound effects on the host immune system. Studies that we have performed on an Ethiopian HIV- immigrant population that has recently reached Israel , lend support to th
T cell clones from a Sjogren's syndrome salivary gland biopsy produce high levels of IL-10.: Clin Exp Immunol. 1996 Feb;103(2):268-72. Unique Identifier : AIDSLINE MED/96152675; Brookes SM; Cohen SB; Price EJ; Webb LM; Feldmann M; Maini RN; Venables PJ; Kennedy Institute of Rheumatology, London, UK.; Sjogren s syndrome (SS) is characterized by a focal periductal salivary gland infiltrate consisting mainly of T and B lymphocytes. Most of the T cells bear the memory CD4+ Th1-like phenotype and express high levels of class II, though CD8+ cells are also present. We have studied 17 labial salivary gland and 15 periphe
Treatment with an anti-CD4 monoclonal antibody strongly ameliorates established rat adjuvant arthritis.: Clin Exp Immunol. 1996 Feb;103(2):273-8. Unique Identifier : AIDSLINE MED/96152676; Pelegri C; Morante MP; Castellote C; Franch A; Castell M; Unit of Physiology, Faculty of Pharmacy, University of Barcelona,; Spain.; Some experimental arthritic diseases can be prevented by treatment with anti-CD4 MoAbs. Trials with ongoing disease have not been successful so far. The aim of this study was to ascertain whether W3/25 could reverse adjuvant arthritis (AA), when beginning treatment on day 14, i.e. when the disease was established. Mor
Pediatric AIDS with severe T-cell depression and hypogammaglobulinemia.: Clin Pediatr (Phila). 1995 Nov;34(11):605-7. Unique Identifier : AIDSLINE MED/96165597; Koutsonikolis A; Nelson RP Jr; Kornfeld SJ; Day NK; Good RA; Division of Allergy and Clinical Immunology, University of South; Florida/All Children's Hospital, St. Petersburg 33701, USA.
More on circumcision [letter]: Clin Pediatr (Phila). 1995 Nov;34(11):623-4. Unique Identifier : AIDSLINE MED/96165604; Fleiss PM
Rahnella aquatilis bacteremia in an HIV-infected intravenous drug abuser.: Diagn Microbiol Infect Dis. 1995 Jul;22(3):293-6. Unique Identifier : AIDSLINE MED/96098384; Funke G; Rosner H; Department of Medical Microbiology, Zurich University Hospital,; Switzerland.; Rahnella aquatilis, an unusual enteric Gram-negative rod, was isolated from three of four blood cultures of an HIV-infected intravenous drug abuser. The outcome was favorable after a 14-day course with ciprofloxacin. The identification of R. aquatilis isolates is discussed and a synopsis of the previously published an
Botryomycosis in a patient with acquired immunodeficiency syndrome.: Cutis. 1995 Sep;56(3):158-60. Unique Identifier : AIDSLINE MED/96098371; Salvemini JN; Baldwin HE; SUNY Health Science Center at Brooklyn, New York 11203, USA.; Botryomycosis is a bacterial infection of either the skin alone or in combination with visceral organs. It resembles a deep fungal infection. A histologic evaluation of cutaneous lesions reveals the characteristic Splendore-Hoepple phenomena and assists with management. Patients with acquired immunodeficiency syndrome
Caring for HIV-infected drug users: a provider's perspective [editorial]: Cutis. 1995 Nov;56(5):250-2. Unique Identifier : AIDSLINE MED/96157418; Selwyn PA
Cutaneous Acanthamoeba infection in the acquired immunodeficiency syndrome: response to multidrug therapy.: Cutis. 1995 Nov;56(5):285-7. Unique Identifier : AIDSLINE MED/96157427; Hunt SJ; Reed SL; Mathews WC; Torian B; University of California San Diego Medical Center, USA.; Acanthamoeba, a free-living ameba of soil and water, produces the rare infections of granulomatous amebic encephalitis and amebic keratitis. We report a 38-year-old white man with the acquired immunodeficiency syndrome (AIDS) who experienced Acanthamoeba infection that presented as multiple skin nodules without associ
Alterations of the percentage of lymphocytes in patients with acute myocardial infarction and clinical evaluation.: Chin Med J (Engl). 1995 Oct;108(10):784-6. Unique Identifier : AIDSLINE MED/96147680; Che J; Zhu L; Li K; Chen S; General Hospital of Tianjin Medical University.
[A new antiviral substance against AIDS is already tested by phase II trial (news)]: Dtsch Med Wochenschr. 1996 Jan 5;121(1-2):A21. Unique Identifier : AIDSLINE MED/96171020; Diehl M
[Bartonella (Rochalimaea) infections: cat-scratch disease and bacillary angiomatosis]: Dtsch Med Wochenschr. 1996 Jan 19;121(3):65-9. Unique Identifier : AIDSLINE MED/96163349; Sander A; Kaliebe T; Bredt W; Institut fur Medizinische Mikrobiologie und Hygiene, Freiburg.
Preoperative HIV testing [letter]: Ear Nose Throat J. 1995 Sep;74(9):657. Unique Identifier : AIDSLINE MED/96094071; Pincus RL
Validation of measures of condom and other contraceptive use among women at high risk for HIV infection and unintended pregnancy.: Health Psychol. 1995 Nov;14(6):570-8. Unique Identifier : AIDSLINE MED/96139232; Galavotti C; Cabral RJ; Lansky A; Grimley DM; Riley GE; Prochaska JO; Women's Health and Fertility Branch, Centers for Disease Control; and Prevention, Atlanta, Georgia 30341-3724, USA.; This study assessed the applicability of the transtheoretical model of behavior change (J.O. Prochaska & C.C. DiClemente, 1983, 1984) to the measurement of contraceptive use among 296 women at high risk for HIV infection and transmission. Structural equation modeling suggested that a measure of general contraceptiv
Intestinal and extraintestinal cryptosporidiosis in AIDS patients.: Eur J Clin Microbiol Infect Dis. 1995 Aug;14(8):677-81. Unique Identifier : AIDSLINE MED/96089500; Lopez-Velez R; Tarazona R; Garcia Camacho A; Gomez-Mampaso E; Guerrero A; Moreira V; Villanueva R; Department of Clinical Microbiology & Infectious Diseases,; Hospital Ramon y Cajal, Madrid, Spain.; In a prospective study in AIDS patients with chronic diarrhea, the overall prevalence of intestinal cryptosporidiosis was 15.6% (43/275). The prevalence was higher in homosexual patients (33.3%) than in intravenous drug abusers (10.6%) (p
Prevalence of infection by human T-cell leukemia virus types I and II in southern Spain.: Eur J Clin Microbiol Infect Dis. 1995 Aug;14(8):686-90. Unique Identifier : AIDSLINE MED/96089502; Calderon EJ; Rey C; Medrano FJ; Sanchez-Roman J; Soriano V; Torres Y; Ruiz M; Lissen E; Leal M; Department of Internal Medicine, Viral Hepatitis and AIDS Study; Group, Virgen del Rocio University Hospital, Sevilla, Spain.; To assess the spread of human T-cell leukemia virus (HTLV) type I and II in different population groups at potential risk of infection in Spain , a total of 756 subjects were studied: 453 belonging to groups at risk for retrovirus infection, 255 with diseases potentially linked to HT
Testing of saliva and serum for HIV in high-risk populations. Ad Hoc Group for the Comparative Saliva and Serum Study.: Eur J Clin Microbiol Infect Dis. 1995 Aug;14(8):710-3. Unique Identifier : AIDSLINE MED/96089508; Vall Mayans M; Casabona J; Rabella N; De Miniac D; AIDS Programme, Department of Health, Generalitat de Catalunya,; Barcelona, Spain.; Paired samples of saliva and serum from 286 high-risk subjects were tested for HIV using two commercial enzyme immunoassays following the same WHO testing strategy supplemented with a Western blot technique. Agreement between HIV testing in both sample types was 98.9% (95% confidence interval: 97.7-100). The sensitivi
Lack of inducible nitric oxide synthase activity in T cell clones and T lymphocytes from naive and Leishmania major-infected mice.: Eur J Immunol. 1995 Dec;25(12):3229-34. Unique Identifier : AIDSLINE MED/96140654; Thuring H; Stenger S; Gmehling D; Rollinghoff M; Bogdan C; Institute for Clinical Microbiology and Immunology, University of; Erlangen-Nurnberg, Germany.; Nitric oxide (NO) generated by the inducible isoform of nitric oxide synthase (iNOS) is implicated in a number of immunological processes including killing of intracellular parasites, suppression of T cell proliferation, production of cytokines and destruction of tissue in autoimmune diseases. Considering that cytokin
Mitochondrial perturbations define lymphocytes undergoing apoptotic depletion in vivo.: Eur J Immunol. 1995 Dec;25(12):3277-84. Unique Identifier : AIDSLINE MED/96140663; Castedo M; Macho A; Zamzami N; Hirsch T; Marchetti P; Uriel J; Kroemer G; CNRS-UPR420, Villejuif, France.; We have recently shown that lymphocyte apoptosis induced by dexamethasone or superantigens is accompanied by reduction of mitochondrial transmembrane potential (delta psi m) which precedes nuclear DNA fragmentation. Here, we demonstrate that fluorochromes such as 3,3 dihexyloxacarbocyanine iodide [DiOC6(3)] which mea
Altered Th1/Th2 balance associated with the immunosuppressive/protective effect of the H-2Ab allele on the response to allo-4-hydroxyphenylpyruvate dioxygenase.: Eur J Immunol. 1995 Dec;25(12):3285-9. Unique Identifier : AIDSLINE MED/96140664; Brunner M; Larsen S; Sette A; Mitchison A; Deutsches Rheuma-Forschungszentrum, Berlin, Germany.; The H-2Ab allele exerts a dominant down-regulatory effect on the anti-allo-HPPD (4-hydroxyphenylpyruvate dioxygenase) antibody response, through a hitherto unknown mechanism. In the present study, the allo-variable peptide bound to responder H-2Ak molecules with higher affinity than to H-2Ab ones, arguing against the
CD14lowCD16high: a cytokine-producing monocyte subset which expands during human immunodeficiency virus infection.: Eur J Immunol. 1995 Dec;25(12):3418-24. Unique Identifier : AIDSLINE MED/96140681; Thieblemont N; Weiss L; Sadeghi HM; Estcourt C; Haeffner-Cavaillon N; Laboratory of Immunopathology, INSERM U430, Hopital Broussais,; Paris, France.; Infection with the human immunodeficiency virus HIV-1 is associated with the expansion of a CD14lowCD16high monocyte subset in peripheral blood. This subset, which represents a minor subpopulation of monocytes in healthy individuals, increases during HIV infection and, in patients with AIDS, may represent up to 40% of
Definition of sites on HLA-DR1 involved in the T cell response to staphylococcal enterotoxins E and C2.: Eur J Immunol. 1995 Dec;25(12):3437-44. Unique Identifier : AIDSLINE MED/96140684; Hargreaves RE; Brehm RD; Tranter H; Warrens AN; Lombardi G; Lechler RI; Department of Immunology, Royal Postgraduate Medical School,; Hammersmith Hospital, London, GB.; We have exploited the relative inefficiency of interaction between staphylococcal enterotoxins, SEE or SEC2, and H-2Ek compared to HLA-DR1 molecules to deduce which regions of the major histocompatibility complex (MHC) class II molecule are involved in the T cell response to these superantigens. Transfectants expressi
C-C chemokines, but not the C-X-C chemokines interleukin-8 and interferon-gamma inducible protein-10, stimulate transendothelial chemotaxis of T lymphocytes.: Eur J Immunol. 1995 Dec;25(12):3482-8. Unique Identifier : AIDSLINE MED/96140690; Roth SJ; Carr MW; Springer TA; Center for Blood Research, Boston, MA 02115, USA.; Eight chemokines were tested for ability to elicit transendothelial chemotaxis of unstimulated peripheral blood T lymphocytes. The C-C chemokines monocyte chemotactic protein (MCP)-2, MCP-3, RANTES, macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta, and, as previously described, MCP-1 induced significant, dose
Default development of cloned human naive CD4 T cells into interleukin-4- and interleukin-5- producing effector cells.: Eur J Immunol. 1995 Dec;25(12):3517-20. Unique Identifier : AIDSLINE MED/96140696; Yang LP; Byun DG; Demeure CE; Vezzio N; Delespesse G; University of Montreal, Louis-Charles Simard Research Center,; Notre-Dame Hospital, Montreal, Canada.; It was recently demonstrated that naive human and mouse CD4 T cells release low but sufficient levels of interleukin (IL)-4 at priming to support their development into IL-4 producers. To determine whether this IL-4 is produced by a minor subset of cells, freshly isolated human naive CD4 T cells were directly cloned b
Analysis of major histocompatibility complex class I-restricted hapten recognition by mutation of the V-J joining of T cell receptor alpha chains.: Eur J Immunol. 1996 Jan;26(1):179-86. Unique Identifier : AIDSLINE MED/96152743; von Bonin A; Plaga S; Ruh H; Hebbelmann S; Pflugfelder U; Martin S; Weltzien HU; Max-Planck-Institut fur Immunbiologie, Freiburg, Germany.; Hapten-specific T cell responses are responsible for chemically induced immune disorders. However, the molecular details of hapten interactions with T cell receptors (TCR) are poorly understood. Recent studies of trinitrophenyl (TNP)-specific responses revealed major histocompatibility complex-associated TNP-peptides
The potential importance of MHC mimicry by HIV in the pathogenesis of AIDS.: Biochem Soc Trans. 1995 Aug;23(3):471S. Unique Identifier : AIDSLINE MED/96077332; Sheikh J; Ongradi J; Austen B; Dalgleish A; Division of Oncology, St. George's Hospital Medical School,; Cranmer Terrace, London.
The role of myristoylation in the interactions between human immunodeficiency virus type I Nef and cellular proteins.: Biochem Soc Trans. 1995 Aug;23(3):557-61. Unique Identifier : AIDSLINE MED/96077225; Harris M; Department of Veterinary Pathology, University of Glasgow,; Scotland, UK.
Subacute measles encephalitis in a boy with perinatal HIV-1 infection [letter]: Dev Med Child Neurol. 1995 Dec;37(12):1117-9. Unique Identifier : AIDSLINE MED/96146642; Vigliano P; Boffi P; Giordana MT; Tovo PA; Palomba E; Rigardetto R
Decreased interleukin-2 production in murine acute pancreatitis: potential for immunomodulation [see comments]: Gastroenterology. 1996 Feb;110(2):583-8. Unique Identifier : AIDSLINE MED/96156062; Curley P; Nestor M; Collins K; Saporoschetz I; Mendez M; Mannick JA; Rodrick ML; Department of Surgery, Brigham and Women's Hospital, Boston,; Massachusetts, USA.; BACKGROUND & AIMS: The role of the cytokine interleukin 2 ( IL-2 ) has long been recognized as central to normal immunologic function and defense against infection after burns and trauma, but little effort has been directed towards its role in acute pancreatitis (AP), wh
Natural history and prognosis of diarrhea of unknown cause in patients with acquired immunodeficiency syndrome (AIDS).: Gastrointest Endosc. 1995 Nov;42(5):496. Unique Identifier : AIDSLINE MED/96149678; Fennerty MB
IRINE symposium; immunologic advances in the Commonwealth of Independent States(Part 1).: Allergy Proc. 1995 Jul-Aug;16(4):171-5. Unique Identifier : AIDSLINE MED/96043892; DuBuske LM; Harvard University Medical School, Boston, Massachusetts, USA.; This symposium describes the advances in immunology that have occurred in the Commonwealth of Independent States. The worldwide difficulties of allergists and immunologists who face problems including increasing morbidity and mortality from HIV, immunoregulatory disorders, and asthma are also germane to our colleagues
Immunopathogenesis of HIV infection: a specific anti-HIV tolerance as a mechanism of control of disease progression.: Allergy Proc. 1995 Jul-Aug;16(4):203-7. Unique Identifier : AIDSLINE MED/96043896; Sidorovitch IG; Ignatieva GA; Biotechnology Laboratory, Ministry of Public Health, Moscow,; Russia.; The pathogenesis of HIV has been evaluated by many investigators, yet the precise reasons for certain patients developing lethal infection while others appear to live for long periods tolerating the HIV virus remain to be determined. The immune response to HIV may be critical in the development of the fatal infected s
Molecular pathogenesis of non-Hodgkin lymphoma: a clinical perspective.: Haematologica. 1995 Sep-Oct;80(5):454-72. Unique Identifier : AIDSLINE MED/96058921; Gaidano G; Pastore C; Volpe G; Laboratorio di Medicina e Oncologia Molecolare, Ospedale San; Luigi Gonzaga, Universita di Torino, Orbassano (TO), Italy.; Despite a common origin from mature lymphoid cells, non-Hodgkin lymphomas (NHL) represent a surprisingly heterogeneous group of lymphoid malignancies whose classification is continuously being remodeled. The most recent proposal, the Revised European-American classification, introduces pathogenetic features among the
Risk behaviour and STD acquisition in genitourinary clinic attenders who have travelled.: Genitourin Med. 1995 Dec;71(6):351-4. Unique Identifier : AIDSLINE MED/96164962; Hawkes S; Hart GJ; Bletsoe E; Shergold C; Johnson AM; Academic Department of Genito-Urinary Medicine, Mortimer Market; Centre, London, UK.; OBJECTIVE--To investigate the travel history of clients presenting at a genitourinary medicine (GUM) clinic in order to assess the contribution made by sexual partnerships abroad to STD transmission in the UK. SUBJECTS--386 old and new clients who attended during a 3-month period and who had travelled abroad in the 3
Response to influenza immunisation in asymptomatic HIV infected men.: Genitourin Med. 1995 Dec;71(6):355-7. Unique Identifier : AIDSLINE MED/96164963; Huengsberg M; Chakraverty MP; Cooper G; Shahmanesh M; Department of Genitourinary Medicine, General Hospital,; Birmingham, UK.; OBJECTIVE--This study aimed to determine if patients with HIV infection can develop a significant antibody response to influenza immunisation, and whether such immunisation is detrimental to the progression of their HIV illness. DESIGN--Prospective, non-randomised study. METHODS--The titres of antibody response to inf
AIDS in Africans living in London.: Genitourin Med. 1995 Dec;71(6):358-62. Unique Identifier : AIDSLINE MED/96164964; O'Farrell N; Lau R; Yoganathan K; Bradbeer CS; Griffin GE; Pozniak AL; Department of Genitourinary Medicine, Guy's Hospital, London.; OBJECTIVES--To investigate the presentation of HIV infection and AIDS amongst Africans diagnosed with AIDS living in London. METHODS--Identification of all AIDS cases of African origin attending four HIV specialist centres in South London--Guy s, King s, St George s and St Thomas Hospitals--up to March 1994, by retro
Prevalence of antibodies to HIV-1 and HIV-2 in women attending a sexually transmitted disease clinic in Luanda, Angola [letter]: Genitourin Med. 1995 Dec;71(6):413-4. Unique Identifier : AIDSLINE MED/96164980; Portincasa P; Zannino T; Dettori G; Chezzi C; Dos Santos N; Vandunen M; Lemos C; Rubino S; Cappuccinelli P; Colombo MM
Anaphylaxis due to liposomal amphotericin (AmBisome) [letter]: Genitourin Med. 1995 Dec;71(6):414. Unique Identifier : AIDSLINE MED/96164981; Bates CM; Carey PB; Hind CR
Polypoidal and giant molluscum contagiosum [letter]: Genitourin Med. 1995 Dec;71(6):417. Unique Identifier : AIDSLINE MED/96164985; Rea AJ; Goh BT
Sequential production of Th1 and Th2 cytokines in response to live bacillus Calmette-Guerin.: Immunology. 1995 Dec;86(4):512-8. Unique Identifier : AIDSLINE MED/96165025; Sander B; Skansen-Saphir U; Damm O; Hakansson L; Andersson J; Andersson U; Department of Pathology, Faculty of Health Sciences, University; of Linkoping, Sweden.; Causes of individual variation in susceptibility to mycobacterial diseases are only partly understood. An efficient cell-mediated immune response is crucial for resistance. Macrophages and T cells interact to eliminate the mycobacteria, partially through the effects of secreted cytokines. A vigorous anti-bacterial inf
CD45RO expression on bovine T cells: relation to biological function.: Immunology. 1995 Dec;86(4):537-44. Unique Identifier : AIDSLINE MED/96165029; Bembridge GP; MacHugh ND; McKeever D; Awino E; Sopp P; Collins RA; Gelder KI; Howard CJ; Institute for Animal Health, Compton Laboratory, UK.; The 180,000 MW isoform of CD45 (CD45RO) has been identified in cattle with a novel monoclonal antibody (mAb) (IL-A116). This has allowed a more precise analysis of T-cell function in relation to CD45 isoform expression. Within the CD4+ and CD8+ T-cell populations, CD45RO+ and CD45RO- subsets were evident. Most CD4+ an
The 5' coding sequence of IL-2 receptor alpha chain mRNA mediates mRNA stabilization by HTLV-1 Rex.: Immunology. 1995 Dec;86(4):551-5. Unique Identifier : AIDSLINE MED/96165031; Kanamori H; Kodama T; Yazaki Y; Third Department of Internal Medicine, University of Tokyo,; Japan.; The interleukin-2 receptor alpha chain (IL-2R alpha) is a T-cell growth factor receptor and is known to be induced in helper T cells by infection with human T-cell leukaemia virus type-1 (HTLV-1). The Rex protein of HTLV-1 has been shown to stabilize IL-2R alpha mRNA. Although the 3 untranslated region of many RNA ha
IgA subclasses in HIV disease: dichotomy between raised levels in serum and decreased secretion rates in saliva.: Immunology. 1995 Dec;86(4):556-9. Unique Identifier : AIDSLINE MED/96165032; Sweet SP; Rahman D; Challacombe SJ; Department of Oral Medicine and Pathology, UMDS Guy's Hospital,; London, UK.; This study sought to determine IgA, IgA1 and IgA2 concentrations and secretion rates in unstimulated whole saliva and stimulated parotid saliva and IgA, IgA1 and IgA2 concentrations in serum from asymptomatic human immunodeficiency virus (HIV)-infected, acquired immune deficiency syndrome (AIDS) and control subjects.
Major histocompatibility complex class I presentation of exogenous and endogenous protein-derived peptides by a transfected human monocyte cell line.: Immunology. 1995 Dec;86(4):606-11. Unique Identifier : AIDSLINE MED/96165039; Harris PE; Colovai AI; Maffei A; Liu Z; Foca NS; Department of Pathology, College of Physicians and Surgeons of; Columbia University, New York, NY, USA.; Monocyte/macrophages are professional antigen-presenting cells of the cellular immune system, serving to generate peptides for major histocompatibility complex (MHC) class II-restricted recognition by CD4+ T-lymphocyte effector cells. Antigen presentation by these cells involves the internalization of extracellular pr
Over-expression of hepatocyte growth factor in human Kaposi's sarcoma.: Int J Cancer. 1996 Jan 17;65(2):168-72. Unique Identifier : AIDSLINE MED/96152765; Maier JA; Mariotti M; Albini A; Comi P; Prat M; Comogilio PM; Soria MR; Department of Biological and Technological Research-Dibit, San; Raffaele Institute, Milan, Italy.; Kaposi s sarcoma is a highly vascularized multifocal tumor which frequently appears as a complication of HIV infection. It has been suggested that a disorder in the cytokine network may contribute to the development of the disease. We examined the expression of several cytokines in human sporadic Kaposi s-sarcoma spec
Kaposi's sarcoma in childhood: an analysis of 100 cases from Uganda and relationship to HIV infection.: Int J Cancer. 1996 Jan 17;65(2):200-3. Unique Identifier : AIDSLINE MED/96152770; Ziegler JL; Katongole-Mbidde E; Uganda Cancer Institute, Kampala, Uganda.; We report 100 cases of Kaposi s sarcoma (KS) in children under 15 years of age treated at the Uganda Cancer Institute in the 6-year period 1989-1994. The incidence of childhood KS has risen more than 40-fold in the era of AIDS, and 78% of 63 cases tested were seropositive for HIV-1
Patterns of HTLV-I infection among family members of patients with adult T-cell leukemia/lymphoma and HTLV-I associated myelopathy/tropical spastic paraparesis [letter]: Int J Cancer. 1996 Jan 17;65(2):272-3. Unique Identifier : AIDSLINE MED/96152781; Wilks R; Hanchard B; Morgan O; Williams E; Cranston B; Smith ML; Rodgers-Johnson P; Manns A
Stereochemical analysis of the antigenic tip of the V3 loop peptide of HIV-1 gp120.: Int J Pept Protein Res. 1995 Nov;46(5):359-65. Unique Identifier : AIDSLINE MED/96139684; Gunasekaran K; Ramakrishnan C; Balaram P; Molecular Biophysics Unit, Indian Institute of Science,; Bangalore, India.; A novel multiple turn conformation has been observed for a segment GPGRAFY in the crystal structure of a complex of HIV-1 gp120 V3 loop peptide with the Fab fragment of a neutralizing antibody [Ghiara et al. (1994) Science 264, 82-85]. A structural motif has been defined for the peptide segment, employing idealized ba
[Therapy and prevention of pneumocystis carinii pneumonia]: Internist (Berl). 1995 Dec;36(12):1150-5. Unique Identifier : AIDSLINE MED/96137007; Goebel FD; Bogner JR; Medizinische Poliklinik, Klinikum Innenstadt,; Ludwig-Maximilians-Universitat, Munchen.
[Renaissance of tuberculosis?]: Internist (Berl). 1995 Dec;36(12):1162-73. Unique Identifier : AIDSLINE MED/96137009; Meyer FJ; Konietzko N; Abteilung Pneumologie, Ruhrlandklinik, Universitatsklinik; Essen-Heidhausen.
[New strategies in the treatment of chronic viral hepatitis (news)]: Internist (Berl). 1995 Dec;36(12):1201. Unique Identifier : AIDSLINE MED/96137014; Manns M; Neuhaus P
[Acquired ichthyosis-like skin disease. A challenge for diagnostic evaluation]: Hautarzt. 1995 Dec;46(12):836-40. Unique Identifier : AIDSLINE MED/96136410; Kutting B; Traupe H; Universitatshautklinik, Munster.; We report on four patients with acquired ichthyosis-like skin lesions seen in our out-patients clinic in the last 6 years. Emphasis is placed on the case of a 25-year-old patient who suffered from mycosis fungoides with the clinical features of an acquired ichthyosis-like condition. Three further observations illustr
Activation of lavage lymphocytes in lung injuries caused by radiotherapy for lung cancer.: Int J Radiat Oncol Biol Phys. 1996 Jan 15;34(2):459-67. Unique Identifier : AIDSLINE MED/96158778; Nakayama Y; Makino S; Fukuda Y; Min KY; Shimizu A; Ohsawa N; First Department of Internal Medicine, Osaka Medical College,; Japan.; PURPOSE: Radiation pneumonitis sometimes extends beyond the irradiated area of a lung and can also affect the opposite lung. Some immunological mechanisms, in addition to simple direct injury of the lungs by radiation, seem to be involved in the onset of radiation pneumonitis. To clarify such mechanisms, the effects o
Strand displacement synthesis of the long terminal repeats by HIV reverse transcriptase.: J Biol Chem. 1996 Jan 26;271(4):1966-71. Unique Identifier : AIDSLINE MED/96147167; Fuentes GM; Rodriguez-Rodriguez L; Palaniappan C; Fay PJ; Bambara RA; Department of Microbiology & Immunology, University of Rochester,; School of Medicine and Dentistry, New York 14642, USA.; According to the current model for retroviral replication, strand displacement of the long terminal repeat (LTR) is a necessary step during plus strand DNA synthesis in vivo. We have investigated the ability of human immunodeficiency virus reverse transcriptase (HIV-RT) to synthesize in vitro over a 634-nucleotide HIV
Helix structure and ends of RNA/DNA hybrids direct the cleavage specificity of HIV-1 reverse transcriptase RNase H.: J Biol Chem. 1996 Jan 26;271(4):2063-70. Unique Identifier : AIDSLINE MED/96147182; Palaniappan C; Fuentes GM; Rodriguez-Rodriguez L; Fay PJ; Bambara RA; Department of Biochemistry, University of Rochester, New York; 14642, USA.; RNA/DNA hybrids in human immunodeficiency virus (HIV) replication are cleaved by HIV-1 reverse transcriptase (RT) H in locations determined by hybrid structure. Minus strand DNA synthesis is accompanied by cleavage of template viral RNA directed by RT positioned at the growing 3 DNA end. Some RNA remains as oligomers
Cultured AIDS-related Kaposi's sarcoma (AIDS-KS) cells demonstrate impaired bioenergetic adaptation to oxidant challenge: implication for oxidant stress in AIDS-KS pathogenesis.: J Cell Biochem. 1995 Nov;59(3):317-28. Unique Identifier : AIDSLINE MED/96155663; Mallery SR; Bailer RT; Hohl CM; Ng-Bautista CL; Ness GM; Livingston BE; Hout BL; Stephens RE; Brierley GP; Department of Dentistry, College of Dentistry, Ohio State; University, Columbus 43210-1241, USA.; Despite its recognition as the most prevalent HIV associated cancer, speculation still abounds regarding the pathogenesis of AIDS-related Kaposi s sarcoma (AIDS-KS). However, it has been established that both cytokines, e.g. IL-6, and HIV-associated products, e.g., Tat, are integral in AIDS-KS cellular proliferation.
Increased expression of Candida albicans secretory proteinase, a putative virulence factor, in isolates from human immunodeficiency virus-positive patients.: J Clin Microbiol. 1995 Oct;33(10):2543-9. Unique Identifier : AIDSLINE MED/96087184; Ollert MW; Wende C; Gorlich M; McMullan-Vogel CG; Borg-von Zepelin M; Vogel CW; Korting HC; Department of Dermatology, Ludwig-Maximilians-Universitat; Munchen, Germany.; The increased prevalence and the severity of oropharyngeal candidiasis in human immunodeficiency virus (HIV)-positive patients are attributed exclusively to the virus-induced immune deficiency of the host. The present study was aimed at answering the question of whether Candida albicans secretory proteinase, a putativ
Human cytomegalovirus (CMV) DNA in plasma reflects quantity of CMV DNA present in leukocytes.: J Clin Microbiol. 1995 Oct;33(10):2607-11. Unique Identifier : AIDSLINE MED/96087195; Zipeto D; Morris S; Hong C; Dowling A; Wolitz R; Merigan TC; Rasmussen L; Division of Infectious Diseases, Stanford University School of; Medicine, California 94305, USA.; A quantitative DNA amplification assay for human cytomegalovirus ( CMV ) DNA has been used to evaluate the relationship between quantities of CMV DNA in plasma and those in infected leukocytes (WBC) from human immunodeficiency
Torulopsis glabrata: azole susceptibilities by microdilution colorimetric and macrodilution broth assays.: J Clin Microbiol. 1995 Oct;33(10):2612-5. Unique Identifier : AIDSLINE MED/96087196; Tiballi RN; Zarins LT; He X; Kauffman CA; Department of Internal Medicine, Veterans Affairs Medical Center,; Ann Arbor, Michigan 48105, USA.; Fluconazole and itraconazole MICs were determined by both the standard macrodilution method of the National Committee for Clinical Laboratory Standards and a colorimetric broth microdilution method for 140 isolates of Torulopsis (Candida) glabrata obtained over a 15-year period. Using the method of the National Commit
Cervical lymphadenitis caused by a fastidious mycobacterium closely related to Mycobacterium genavense in an apparently immunocompetent woman: diagnosis by culture-free microbiological methods.: J Clin Microbiol. 1995 Oct;33(10):2670-4. Unique Identifier : AIDSLINE MED/96087207; Bosquee L; Bottger EC; De Beenhouwer H; Fonteyne PA; Hirschel B; Larsson L; Meyers WM; Palomino JC; Realini L; Rigouts L; et al; Hopital de Verviers, Verviers, Antwerp, Belgium.; Fastidious mycobacteria usually infect immunocompromised hosts (human immunodeficiency virus-infected or otherwise immunosuppressed patients). We here describe severe lymphadenitis, caused by a fastidious mycobacterium closely related to Mycobacterium genavense, in an apparently immunocompetent woman, whose brother ha
Fluconazole- and itraconazole-resistant Candida albicans strains from AIDS patients: multilocus enzyme electrophoresis analysis and antifungal susceptibilities.: J Clin Microbiol. 1995 Oct;33(10):2732-7. Unique Identifier : AIDSLINE MED/96087219; Le Guennec R; Reynes J; Mallie M; Pujol C; Janbon F; Bastide JM; Laboratoire d'Immunologie et Parasitologie, Faculte de; Pharmacie, Montpellier, France.; Multilocus enzyme electrophoresis and in vitro susceptibility testing with a broth microdilution method were used to analyze Candida albicans strain diversity in four AIDS patients with recurrent oropharyngeal candidiasis who successively developed clinical resistance to fluconazole (FCZ) and itraconazole (ITZ). One t
Nonisotopic hybridization assay for determination of relative amounts of genotypic human immunodeficiency virus type 1 zidovudine resistance.: J Clin Microbiol. 1995 Oct;33(10):2777-80. Unique Identifier : AIDSLINE MED/96087230; Eastman PS; Boyer E; Mole L; Kolberg J; Urdea M; Holodniy M; Chiron Corporation, Emeryville, California 94608, USA.; A nonisotopic hybridization assay for human immunodeficiency virus genotypic zidovudine resistance determination is described. Biotinylated PCR product was hybridized with enzyme-labeled probes for wild-type or resistant mutant sequences and detected colorimetrically or chemiluminescently in a microplate format. Chang
Recombinant interferon-alpha selectively inhibits the production of interleukin-5 by human CD4+ T cells.: J Clin Invest. 1996 Jan 15;97(2):309-15. Unique Identifier : AIDSLINE MED/96149155; Schandene L; Del Prete GF; Cogan E; Stordeur P; Crusiaux A; Kennes B; Romagnani S; Goldman M; Department of Immunology, Hopital Erasme-Cliniques; Universitaires de Bruxelles, Belgium.; The effects of recombinant IFN-alpha on the production of IL-5 by human CD4+ T cells were first analyzed on resting CD4+ T cells purified from normal PBMC and stimulated either with a combination of PMA and anti-CD28 mAb or anti-CD3 mAb cross-linked on B7-1/CD32-transfected mouse fibroblasts. We found that IFN-alpha p
Dynamics of viral replication in infants with vertically acquired human immunodeficiency virus type 1 infection.: J Clin Invest. 1996 Jan 15;97(2):323-30. Unique Identifier : AIDSLINE MED/96149157; De Rossi A; Masiero S; Giaquinto C; Ruga E; Comar M; Giacca M; Chieco-Bianchi L; Institute of Oncology, InterUniversity Center for Cancer; Research, AIDS Reference Center, University of Padova, Italy.; About one-third of vertically HIV-1 infected infants develop AIDS within the first months of life; the remainder show slower disease progression. We investigated the relationship between the pattern of HIV-1 replication early in life and disease outcome in eleven infected infants sequentially studied from birth. Viral
Purification and characterization of a naturally processed hepatitis B virus peptide recognized by CD8+ cytotoxic T lymphocytes.: J Clin Invest. 1996 Jan 15;97(2):577-84. Unique Identifier : AIDSLINE MED/96149188; Tsai SL; Chen MH; Yeh CT; Chu CM; Lin AN; Chiou FH; Chang TH; Liaw YF; Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung; Medical College, Taipei, Taiwan.; In vitro studies in patients with hepatitis B virus (HBV) infection have suggested that hepatocytolysis induced by CD8+ cytotoxic T lymphocytes (CTLs) is the most important effector pathway in eliminating infected cells. The recognition is implicated in the endogenously processed HBV antigens in the context of HLA cla
Lymphocyte subset counts in skin puncture and venous blood compared.: J Clin Pathol. 1995 Dec;48(12):1137-8. Unique Identifier : AIDSLINE MED/96165060; Cracknell SE; Hinchliffe RF; Lilleyman JS; University of Sheffield Department of Paediatrics, Children's; Hospital, Western Bank.; To determine whether skin puncture blood can be used reliably for CD4 lymphocyte counts, the numbers of the major subsets of lymphocytes were assessed in paired venous and skin puncture blood samples from 22 children and 10 adults. Paired values were highly correlated, with skin puncture values being about 7% higher t
Need for action against tuberculosis [news]: J Adv Nurs. 1995 Nov;22(5):827. Unique Identifier : AIDSLINE MED/96154759
UK estimate of children affected by HIV [news]: J Adv Nurs. 1995 Nov;22(5):827. Unique Identifier : AIDSLINE MED/96154760
Nurses' knowledge and beliefs about AIDS: comparing nurses in hospital, community and hospice settings.: J Adv Nurs. 1995 Nov;22(5):879-87. Unique Identifier : AIDSLINE MED/96154768; Steele A; Melby V; Robinson Hospital, Ballymoney, Northern Ireland.; The literature reports an ongoing debate amongst nurses regarding the risk of contracting human immunodeficiency virus (HIV) through routine nursing care. An emotionally charged dilemma appears to exist for many nurses regarding what they perceive as conflict between professional obligation and personal risk. This stu
How do nurses inspire and instil hope in terminally ill HIV patients?: J Adv Nurs. 1995 Nov;22(5):888-95. Unique Identifier : AIDSLINE MED/96154769; Cutcliffe JR; Millbrook Mental Health Unit, Sutton-in-Ashfield,; Nottinghamshire, England.; In this study the researcher examined how nurses inspire and instil hope in terminally ill HIV patients. The study therefore focuses on the interventions, attitudes, principles and process utilized by nurses working within a liaison psychiatry unit where in-patient care for terminally ill HIV patients is available. Us
1995: A year of achievement for the ADA [news]: J Am Dent Assoc. 1996 Jan;127(1):26, 28, 30 passim. Unique Identifier : AIDSLINE MED/96171485
[HTLV1 infection and sicca syndrome]: J Fr Ophtalmol. 1995;18(10):597-602. Unique Identifier : AIDSLINE MED/96146812; Hajjar C; Sainte-Foie S; Savin J; Lacave J; Berlet F; Teron-Aboud B; Batelier L; Guillemin B; Service d'Ophtalmologie (specialites chirurgicales), C.H.G.I.; Basse-Terre/Saint-Claude, Guadeloupe.; PURPOSE OF THE STUDY AND MATERIAL: A search for sicca syndrome was performed in 54 HTLV 1 positive patients. Cases of sicca syndrome due to associated pathologies, or iatrogenic, were eliminated from this study. RESULTS: Lacrimal hyposecretion was found in 79% of the cases. Defective lacrimal quality was found in 86%
[Prognosis of retinal detachment in cytomegalovirus retinitis]: J Fr Ophtalmol. 1995;18(10):603-7. Unique Identifier : AIDSLINE MED/96146813; Cochereau I; Korobelnik JF; Petit E; Matheron S; Longuet P; Hoang-Xuan T; Service d'Ophtalmologie, Hopital Bichat-Claude-Bernard, Paris,; France.; PURPOSE: To evaluate the incidence and the prognosis of retinal detachment in CMV retinitis in AIDS. To test intravitreal injections of ganciclovir into the vitreal cavity filled with silicone. METHODS: Among 136 eyes with CMV retinitis, 15 (11%) had retinal det
[Anisocoria disclosing malignant lymphoma]: J Fr Ophtalmol. 1995;18(10):617-20. Unique Identifier : AIDSLINE MED/96146816; Fongione A; Leger F; Paty MC; Diallo Rosier L; De Caqueray C; Fourmaux E; Le Rebeller MJ; Service d'Ophtalmologie, CHR de Bordeaux, Hopital; Pellegrin-Tripode, place Amelie-Raba-Leon.; Intraocular lymphoma is a rare disease. We present a patient in which anisocoria led to the diagnosis of iris lymphoma and systemic malignant non Hodgkin s lymphoma.
[Bilateral acute retinal necrosis in a patient with acquired immunodeficiency syndrome]: J Fr Ophtalmol. 1995;18(10):625-33. Unique Identifier : AIDSLINE MED/96146818; Menerath JM; Gerard M; Laurichesse H; Goldschmidt P; Peigue-Lafeuille H; Rozenberg F; Beytout J; Service d'Ophtalmologie, Hopital Gabriel Montpied, CHU, BP 69,; Clermont-Ferrand.; A case of bilateral progressive outer retinal necrosis occurred after herpes zoster ophthalmicus in a patient with acquired immunodeficiency syndrome. This case does not correspond to the classical picture of progressive outer retinal necrosis. The disease led to blindness despite intravenous therapy with
[Chorioretinal manifestations in AIDS]: J Fr Ophtalmol. 1995;18(10):634-44. Unique Identifier : AIDSLINE MED/96146819; Snyers B; Lefevre A; Zech F; Departement d'Ophtalmologie, Clinique Universitaie Saint-Luc,; Universite Catholique de Louvain, Bruxelles, Belgique.
CD30 expression does not discriminate between human Th1- and Th2-type T cells.: J Immunol. 1996 Feb 15;156(4):1387-91. Unique Identifier : AIDSLINE MED/96164564; Hamann D; Hilkens CM; Grogan JL; Lens SM; Kapsenberg ML; Yazdanbakhsh M; van Lier RA; Central Laboratory of the Netherlands Red Cross Blood Transfusion; Service, University of Amsterdam, The Netherlands.; CD30 is a member of the TNF receptor superfamily that is commonly used as a marker for Hodgkin and Reed-Sternberg cells in Hodgkin s disease. More recently, it has been proposed that CD30 is preferentially up-regulated on Th2-type human T cells. We analyzed regulation of CD30 expression on both peripheral blood T cell
Roles of IFN-gamma and IFN-alpha in IL-12-induced T helper cell-1 development.: J Immunol. 1996 Feb 15;156(4):1442-7. Unique Identifier : AIDSLINE MED/96164572; Wenner CA; Guler ML; Macatonia SE; O'Garra A; Murphy KM; Department of Pathology, Washington University School of; Medicine, St. Louis, MO 63110, USA.; IL-12 and IL-4 direct T cell development toward Th1 and Th2 phenotypes, respectively. While IFN-gamma and IFN-alpha have been reported to regulate Th1 development as well, the mechanism and cellular locus of their effects are unclear. In this study, we use a TCR-transgenic system to examine the actions of these cytoki
The T cell receptor gene usage by simian immunodeficiency virus gag-specific cytotoxic T lymphocytes in rhesus monkeys.: J Immunol. 1996 Feb 15;156(4):1469-75. Unique Identifier : AIDSLINE MED/96164575; Chen ZW; Shen L; Regan JD; Kou Z; Ghim SH; Letvin NL; Harvard Medical School, Beth Israel Hospital, Boston, MA 02215,; USA. Zchen@Bih.Harvard.edu; MHC class I-restricted CTL play an important role in limiting the spread of HIV-1 in the infected individual. Elucidating the molecular interactions of CTL with the virus is, therefore, of central importance for characterizing the immune control of this infection. In exploring this CTL response, we have defined the TC
T cell-derived IL-3 induces the production of IL-4 by non-B, non-T cells to amplify the Th2-cytokine response to a non-parasite antigen in Schistosoma mansoni-infected mice.: J Immunol. 1996 Feb 15;156(4):1482-9. Unique Identifier : AIDSLINE MED/96164577; Kullberg MC; Berzofsky JA; Jankovic DL; Barbieri S; Williams ME; Perlmann P; Sher A; Troye-Blomberg M; Immunobiology Section, National Institute of Allergy and; Infectious Diseases (NIAID), National Institutes of Health,; Bethesda, MD 20892, USA.; We describe a novel amplification mechanism underlying the increased early IL-4 production observed in Schistosoma mansoni-infected mice in response to a non-parasite Ag, sperm whale myoglobin (SwMb). Earlier studies have shown that splenic Fc epsilon R+ non-B, non-T (NBNT) cells from schistosome-infected mice secrete
Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella.: J Immunol. 1996 Feb 15;156(4):1504-14. Unique Identifier : AIDSLINE MED/96164580; VanCott JL; Staats HF; Pascual DW; Roberts M; Chatfield SN; Yamamoto M; Coste M; Carter PB; Kiyono H; McGhee JR; Immunobiology Vaccine Center, University of Alabama Medical; Center, Birmingham 35294, USA.; We have assessed regulatory Th cell and cytokine responses in mice after oral immunization with recombinant Salmonella (BRD 847) expressing fragment C of tetanus toxoid, since little information is available to explain how these vectors induce mucosal IgA responses. A single dose of BRD 847 elicited serum IgG2a and mu
In vitro culture of human peripheral blood monocytes induces hyaluronan binding and up-regulates monocyte variant CD44 isoform expression.: J Immunol. 1996 Feb 15;156(4):1557-65. Unique Identifier : AIDSLINE MED/96164586; Levesque MC; Haynes BF; Department of Medicine, Duke University Medical Center, Durham,; NC 27710, USA.; CD44 is a cell surface proteoglycan homologous to cartilage link protein that serves as a receptor for hyaluronan (HA). CD44 isoforms include an unspliced 80- to 90-kDa standard form (CD44S) and isoforms derived from alternative splicing of nine CD44 variant exons (CD44V). Ligation of CD44 isoforms on monocytes induce
IL-12 expression in AIDS-related lymphoma B cell lines.: J Immunol. 1996 Feb 15;156(4):1626-37. Unique Identifier : AIDSLINE MED/96164595; Benjamin D; Sharma V; Kubin M; Klein JL; Sartori A; Holliday J; Trinchieri G; Division of Hematology and Oncology, Arthur G. James Cancer; Hospital and Research Institute, Columbus, OH 43210, USA.; IL-12 is a 70-kDa heterodimer formed by the 40-kDa heavy chain (p40) and the 35-kDa light chain (p35). Twenty-five Burkitt s lymphoma cell lines (CL) and seven normal lymphoblastoid B CL were studied. The Burkitt s CL included AIDS-associated B CL (AABCL) (7 EBV+/2 EBV-) and non-AABCL (8 EBV+/8 EBV-). Reverse transcri
HIV-1-Tat modulates the function of monocytes and alters their interactions with microvessel endothelial cells. A mechanism of HIV pathogenesis.: J Immunol. 1996 Feb 15;156(4):1638-45. Unique Identifier : AIDSLINE MED/96164596; Lafrenie RM; Wahl LM; Epstein JS; Hewlett IK; Yamada KM; Dhawan S; Laboratory of Developmental Biology, National Institute of Dental; Research, Bethesda, MD 20892, USA.; Monocytes are major targets of HIV infection in patients with AIDS. In vitro infection of monocytes with HIV is associated with increased expression of beta 2 integrins, which increases both monocyte aggregation and monocyte/endothelial adhesion as well as monocyte metalloproteinase (MMP-9) expression. Treatment of pr
Establishment and characterization of a murine CD4+ T cell line and clone that induce experimental autoimmune uveoretinitis in B10.A mice.: J Immunol. 1996 Feb 15;156(4):1654-60. Unique Identifier : AIDSLINE MED/96164598; Rizzo LV; Silver P; Wiggert B; Hakim F; Gazzinelli RT; Chan CC; Caspi RR; Laboratory of Immunology, NEI/NIH, Bethesda, MD 20892-1858, USA.; B10.A mice develop experimental autoimmune uveoretinitis after active immunization with the interphotoreceptor retinoid-binding protein (IRBP). CD4+ T cells play an important role in the development of the disease. In this study we have isolated and characterized a CD4+ T cell line and a T cell clone that induce exper
Evidence for distinct contributions of heavy and light chains to restriction of antibody recognition of the HIV-1 principal neutralization determinant.: J Immunol. 1996 Feb 15;156(4):1676-83. Unique Identifier : AIDSLINE GENBANK/U33142; Watkins BA; Davis AE; Fiorentini S; di Marzo Veronese F; Reitz MS Jr; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, MD 20892, USA.; We have used phage Ab display technology to analyze two mAbs to HIV-1 envelope proteins gp120 and gp41. From the data obtained we are able to demonstrate that the recognition of the principal neutralization determinant of different strains of HIV-1 by neutralizing mAb M77 is restricted by its heavy and light chains in
Alterations in the immune response of human immunodeficiency virus (HIV)-infected subjects treated with an HIV-specific protease inhibitor, ritonavir.: J Infect Dis. 1996 Feb;173(2):321-9. Unique Identifier : AIDSLINE MED/96162089; Kelleher AD; Carr A; Zaunders J; Cooper DA; Centre for Immunology, HIV-Medicine Unit, St. Vincent's Hospital,; Sydney, Australia.; Effects of a human immunodeficiency virus (HIV) type 1 protease inhibitor, ritonavir , were evaluated in 21 patients enrolled in a phase I/II study. The magnitude and rates of CD4 and CD8 lymphocyte increase, changes in subsets of CD4 and CD8 lymphocyt
A dose-ranging study of a prototype synthetic HIV-1MN V3 branched peptide vaccine. The National Institute of Allergy and Infectious Diseases AIDS Vaccine Evaluation Group.: J Infect Dis. 1996 Feb;173(2):330-9. Unique Identifier : AIDSLINE MED/96162090; Gorse GJ; Keefer MC; Belshe RB; Matthews TJ; Forrest BD; Hsieh RH; Koff WC; Hanson CV; Dolin R; Weinhold KJ; Frey SE; Ketter N; Fast PE; Division of Infectious Diseases and Immunology, Saint Louis; University School of Medicine, Missouri 63110-0250, USA.; A phase I double-blind trial was done to examine the safety and immunogenicity of a prototype synthetic human immunodeficiency virus type 1 MN strain (HIV-1MN) third variable region domain (V3) branched peptide vaccine in HIV-1-uninfected healthy adult volunteers. Subjects were randomly assigned to receive 20, 100, or
Immunization with envelope subunit vaccine products elicits neutralizing antibodies against laboratory-adapted but not primary isolates of human immunodeficiency virus type 1. The National Institute of Allergy and Infectious Diseases AIDS Vaccine Evaluation Group.: J Infect Dis. 1996 Feb;173(2):340-8. Unique Identifier : AIDSLINE MED/96162091; Mascola JR; Snyder SW; Weislow OS; Belay SM; Belshe RB; Schwartz DH; Clements ML; Dolin R; Graham BS; Gorse GJ; Keefer MC; McElrath MJ; Walker MC; Wagner KF; McNeil JG; McCutchan FE; Burke DS; Division of Retrovirology, Walter Reed Army Institute of; Research, Henry M. Jackson Foundation for the Advancement of; Military Medicine, Rockville, MD 20850, USA.; Phase I studies of volunteers not infected with human immunodeficiency virus type 1 (HIV-1) have shown that immunization with envelope subunit vaccine products elicits antibodies that neutralize laboratory-adapted (prototype) HIV-1 strains in vitro. Prototype strains are adapted to grow in continuous (neoplastic) cell
Relation between changes in cellular load, evolution of viral phenotype, and the clonal composition of virus populations in the course of human immunodeficiency virus type 1 infection.: J Infect Dis. 1996 Feb;173(2):349-54. Unique Identifier : AIDSLINE MED/96162092; Koot M; van 't Wout AB; Kootstra NA; de Goede RE; Tersmette M; Schuitemaker H; Department of Clinical Viro-Immunology, Netherlands Red Cross; Blood Transfusion Service, University of Amsterdam, Netherlands.; The relationship between the evolution of human immunodeficiency virus type 1 (HIV-1) biologic phenotype, changes in the proportion of infected peripheral blood mononuclear cells, and the relative contribution of non-syncytium-inducing (NSI) and syncytium-inducing (SI) HIV-1 variants to virus load was studied during t
Lamivudine or stavudine in two- and three-drug combinations against human immunodeficiency virus type 1 replication in vitro.: J Infect Dis. 1996 Feb;173(2):355-64. Unique Identifier : AIDSLINE MED/96162093; Merrill DP; Moonis M; Chou TC; Hirsch MS; Infectious Disease Unit, Massachusetts General Hospital, Harvard; Medical School, Boston 02114, USA.; Two- and three-drug combinations of lamivudine or stavudine with other antiretroviral drugs were evaluated for activity against human immunodeficiency virus type 1 (HIV-1) activity in peripheral blood mononuclear cells. Other agents included zidovudin
Haemophilus ducreyi elicits a cutaneous infiltrate of CD4 cells during experimental human infection.: J Infect Dis. 1996 Feb;173(2):394-402. Unique Identifier : AIDSLINE MED/96162098; Spinola SM; Orazi A; Arno JN; Fortney K; Kotylo P; Chen CY; Campagnari AA; Hood AF; Department of Medicine, Indiana University, Indianapolis, USA.; Human subjects were experimentally infected with Haemophilus ducreyi for up to 2 weeks. Bacterial suspensions were delivered into the epidermis and dermis through puncture wounds made by an allergy-testing device. Subjects developed papular lesions that evolved into pustules resembling natural disease. Some papular le
Soluble tumor necrosis factor-alpha receptor type II (sTNF alpha RII) correlates with human immunodeficiency virus (HIV) RNA copy number in HIV-infected patients.: J Infect Dis. 1996 Feb;173(2):464-7. Unique Identifier : AIDSLINE MED/96162110; Bilello JA; Stellrecht K; Drusano GL; Stein DS; Department of Medicine, Albany Medical College, New York 12208,; USA.; Soluble TNF receptor type II (sTNF alpha RII) levels in serum, CD4 lymphocyte counts, and human immunodeficiency virus (HIV) burdens have each been correlated with HIV disease progression. The level of sTNF alpha RII and HIV RNA was measured in serum and the CD4 lymphocyte count of 25 HIV-infected patients was determi
Relationship between infectious cell-associated human immunodeficiency virus type 1 load, T lymphocyte subsets, and stage of infection in homosexual men.: J Infect Dis. 1996 Feb;173(2):468-71. Unique Identifier : AIDSLINE MED/96162111; Margolick JB; Farzadegan H; Hoover DR; Saah AJ; Department of Molecular Microbiology and Immunology, Johns; Hopkins University School of Hygiene and Public Health, Baltimore; 21205, USA.; The relationship between cell-associated infectious human immunodeficiency virus type 1 (HIV) load (infectious units/10(6) peripheral blood mononuclear cells [IUPM]) and phenotypes of CD4+ and CD8+ lymphocytes was studied. IUPM were measured in 242 HIV-infected homosexual men by quantitative microculture and T cell su
Human immunodeficiency virus type 1 (HIV-1)-seronegative injection drug users at risk for HIV exposure have antibodies to HLA class I antigens and T cells specific for HIV envelope.: J Infect Dis. 1996 Feb;173(2):472-6. Unique Identifier : AIDSLINE MED/96162112; Beretta A; Weiss SH; Rappocciolo G; Mayur R; De Santis C; Quirinale J; Cosma A; Robbioni P; Shearer GM; Berzofsky JA; Villa ML; Siccardi AG; Clerici M; Department of Biology and Technology, S. Raffaele Scientific; Institute, Milan, Italy.; The question of whether persistently seronegative persons at high risk for human immunodeficiency virus type 1 (HIV-1) infection exhibit HIV-1-specific T cell responses and antibodies to HIV-1 envelope epitopes shared with selected HLAs was assessed. These antibodies are not detectable by conventional serologic method
Recognition of the highly conserved YMDD region in the human immunodeficiency virus type 1 reverse transcriptase by HLA-A2-restricted cytotoxic T lymphocytes from an asymptomatic long-term nonprogressor.: J Infect Dis. 1996 Feb;173(2):476-9. Unique Identifier : AIDSLINE MED/96162113; Harrer E; Harrer T; Barbosa P; Feinberg M; Johnson RP; Buchbinder S; Walker BD; AIDS Research Center and Infectious Disease Unit, Massachusetts; General Hospital, Boston 02114, USA.; The human immunodeficiency virus (HIV) type 1 reverse transcriptase (RT) is an important target for therapeutic intervention and for HIV-1-specific cytotoxic T lymphocytes (CTL). An HLA-A2-restricted CTL epitope containing the sequence YMDD, which is highly conserved among human and animal retroviruses and essential f
Effect of pregnancy on the risk of developing active tuberculosis.: J Infect Dis. 1996 Feb;173(2):488-91. Unique Identifier : AIDSLINE MED/96162116; Espinal MA; Reingold AL; Lavandera M; Division of Public Health Biology and Epidemiology, School of; Public Health, University of California, Berkeley 94720-7360,; USA.; In a case-control study, the effect of recent pregnancy on the risk of developing active tuberculosis among women of reproductive age was investigated in Santo Domingo. Human immunodeficiency virus (HIV)-positive and HIV-negative women diagnosed with new-onset tuberculosis (TB) were compared, respectively, with HIV-po
Primary and secondary syphilis lesions contain mRNA for Th1 cytokines.: J Infect Dis. 1996 Feb;173(2):491-5. Unique Identifier : AIDSLINE GENBANK; Van Voorhis WC; Barrett LK; Koelle DM; Nasio JM; Plummer FA; Lukehart SA; Department of Medicine, University of Washington, Seattle; 98195-7185, USA.; Phagocytosis of Treponema pallidum by cytokine-activated macrophages aids bacterial clearance and lesion resolution in early syphilis. To investigate the cytokine profiles of cells infiltrating primary and secondary syphilis lesions, reverse transcription and polymerase chain reaction (RT-PCR) were used to detect cyto
Cerebrospinal fluid antibodies detected by ELISA against a 33-kDa antigen from spherules of Coccidioides immitis in patients with coccidioidal meningitis. The National Institute of Allergy and Infectious Diseases Mycoses Study Group.: J Infect Dis. 1996 Feb;173(2):499-502. Unique Identifier : AIDSLINE MED/96162119; Galgiani JN; Peng T; Lewis ML; Cloud GA; Pappagianis D; Medical Service, VA Medical Center, Tucson, AZ 85723, USA.; Antibodies against a 33-kDa antigen from Coccidioides immitis were detected by ELISA in patients cerebrospinal fluid (CSF). Anti-33-kDa antibodies were detected at dilutions > 1:80 in only 1 (1.4%) of 73 patients without coccidioidal meningitis but in 74 (71.8%) of 103 with meningitis. Anti-33-kDa antibodies were det
Acyclovir in human immunodeficiency virus patients [letter]: J Infect Dis. 1996 Feb;173(2):504-7. Unique Identifier : AIDSLINE MED/96162121; Stein DS; Graham NM; Park LP; Hoover DR; Saah AJ
Inflammation in human immunodeficiency virus type 1 infection as a cause of decreased plasma retinol [letter]: J Infect Dis. 1996 Feb;173(2):507-9. Unique Identifier : AIDSLINE MED/96162122; Rosales FJ; Ross AC
Hepatitis C virus genotypes in different risk populations in Spain. The Hepatitis-HIV Spanish Study Group [letter]: J Infect Dis. 1996 Feb;173(2):509-12. Unique Identifier : AIDSLINE MED/96162123; Bravo R; Soriano V; Garcia-Samaniego J; Gonzalez J; Castro A; Colmenero M; Carballo E; Mas A; Gonzalez-Lahoz J
Immunologic mechanism for human immunodeficiency virus type 1 gp120 vaccine failure [letter]: J Infect Dis. 1996 Feb;173(2):512-3. Unique Identifier : AIDSLINE MED/96162124; O'Toole C; Muller S; Nara P; Kohler H
Living wills, durable powers of attorney for health care, and HIV infection. The need for statutory reform.: J Leg Med. 1995 Dec;16(4):461-80. Unique Identifier : AIDSLINE MED/96137424; Loue S; Department of Epidemiology and Biostatistics, School of Medicine,; Case Western Reserve University, Cleveland, Ohio, USA.
Vertical transmission of HIV-1 infection. Diagnosis and prevention.: J Fla Med Assoc. 1995 Dec;82(12):825-6. Unique Identifier : AIDSLINE MED/96156899; Ugen KE; Department of Medical Microbiology and Immunology, University of; South Florida College of Medicine, USA.; With an increase in the number of women of childbearing age being infected with HIV-1, the incidence of pediatric AIDS is rising precipitously. Therefore, it is necessary to identify the risks and the potential preventive methods that may be effective in decreasing the transmission from mother to child, i.e., vertical
Limited value of cerebrospinal fluid for direct detection of Toxoplasma gondii in toxoplasmic encephalitis associated with AIDS.: J Neurol. 1995 Oct;242(10):644-9. Unique Identifier : AIDSLINE MED/96122571; Eggers C; Gross U; Klinker H; Schalke B; Stellbrink HJ; Kunze K; Department of Neurology, University Hospital, Hamburg, Germany.; The diagnosis of acquired immunodeficiency syndrome-associated toxoplasmic encephalitis (TE), a typically focal disease resulting from reactivation of tissue cysts, relies mainly on indirect diagnostic methods. In a prospective study, we investigated the value of detection of Toxoplasma gondii in cerebrospinal fluid (
Bacterial pneumonia in adult patients with HIV infection.: J Chemother. 1995 Aug;7(4):292-306. Unique Identifier : AIDSLINE MED/96084088; Moroni M; Franzetti F; Infectious Diseases Clinic, University of Milano, Italy.; Patients with HIV infection are at increased risk for community-acquired bacterial pneumonias, due in part to their defects in B-cell function. Streptococcus pneumoniae is the commonest cause of community-acquired pneumonia, with the second most common bacterial agent being Haemophilus influenzae. These two organisms
Distribution of CD1a-positive Langerhans cells and lymphocyte subsets in transitional cell carcinoma of the urinary bladder. An immunohistological study on frozen sections.: J Pathol. 1995 Dec;177(4):401-6. Unique Identifier : AIDSLINE MED/96165097; Ioachim-Velogianni E; Stavropoulos NE; Kitsiou E; Stefanaki S; Agnantis NJ; Department of Pathology, University of Ioannina Medical School,; Greece.; The distribution of CD1a-positive Langerhans cells, CD4-positive T-helper cells, and CD8-positive T-suppressor cells in 36 patients with transitional cell carcinoma of the urinary bladder was studied immunohistochemically on frozen sections. Multiple tissue specimens from the tumour, the adjacent mucosa, and random bl
Pregnancy, immunosuppression and reactivation of latent toxoplasmosis.: J Perinat Med. 1995;23(3):191-203. Unique Identifier : AIDSLINE MED/96026972; Biedermann K; Flepp M; Fierz W; Joller-Jemelka H; Kleihues P; Department of Gynecology and Obstetrics, University Hospital of; Zurich, Switzerland.; Toxoplasmosis is a chronic, latent infection which can be reactivated in the presence of immunosuppression. The critical question in obstetrics is whether toxoplasmosis may be reactivated in the presence of the physiological immunosuppression of pregnancy. Standard in vitro tests, done in 24 healthy pregnant women and
Post-natal somatic cell gene therapy.: J Postgrad Med. 1994 Jan-Mar;40(1):23-30. Unique Identifier : AIDSLINE MED/96129798; Culver KW; Human Gene Therapy Research Institute, Des Moines, Iowa; 50309-9976, USA.
The mythology of modern medicine--IV. HIV: heuristically important virus. AIDS: advances induced deficiency syndromes.: J Postgrad Med. 1994 Jan-Mar;40(1):42-5. Unique Identifier : AIDSLINE MED/96129805; Kothari MV; Mehta LA; Dept of Anatomy, Seth GS Medical College, Parel, Bombay,; Maharashtra.
Dealing with drug misuse.: J R Soc Health. 1995 Dec;115(6):391-4. Unique Identifier : AIDSLINE MED/96135528; Gabbay MB; University of Manchester.; This paper provides a background to current trends in the treatment of drug misuse in the UK. It presents an argument for adopting a client-centred approach emphasising harm minimisation, as a means of reducing the negative impact of drug misuse behaviour on the community, particularly in housing estates. The paper co
Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibit human immunodeficiency virus replication. 2. Effect of heteroaromatic linkers on the activity of bicyclams.: J Med Chem. 1996 Jan 5;39(1):109-19. Unique Identifier : AIDSLINE MED/96136793; Bridger GJ; Skerlj RT; Padmanabhan S; Martellucci SA; Henson GW; Abrams MJ; Joao HC; Witvrouw M; De Vreese K; Pauwels R; De Clercq E; Johnson Matthey Pharmaceutical Research, West Chester,; Pennsylvania 19380, USA.; A series of bicyclam analogs connected through a heteroaromatic linker have been synthesized and evaluated for their inhibitory effects on HIV-1 (IIIB) and HIV-2 (ROD) replication in MT-4 cells. The activity of pyridine- and pyrazine-linked bicyclams was found to be highly dependent upon the substitution of the hetero
(-)-Arctigenin as a lead structure for inhibitors of human immunodeficiency virus type-1 integrase.: J Med Chem. 1996 Jan 5;39(1):86-95. Unique Identifier : AIDSLINE MED/96136791; Eich E; Pertz H; Kaloga M; Schulz J; Fesen MR; Mazumder A; Pommier Y; Institut fur Pharmazeutische Biologie, Freie Universitat; Berlin, Germany.; The natural dibenzylbutyrolactone type lignanolide (-)-arctigenin (2), an inhibitor of human immunodeficiency virus type-1 (HIV-1) replication in infected human cell systems, was found to suppress the integration of proviral DNA into the cellular DNA genome. In the present study 2 was tested with purified HIV-1 integr
Potent human immunodeficiency virus type 1 protease inhibitors that utilize noncoded D-amino acids as P2/P3 ligands.: J Med Chem. 1996 Jan 5;39(1):96-108. Unique Identifier : AIDSLINE MED/96136792; Jungheim LN; Shepherd TA; Baxter AJ; Burgess J; Hatch SD; Lubbehusen P; Wiskerchen M; Muesing MA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis,; Indiana 46285-1523, USA.; Noncoded D-amino acids have been designed to replace the quinaldic amide-asparaginyl moiety (P2/P3 ligand) found in several potent human immunodeficiency virus (HIV) protease inhibitors such as LY289612. The substituted nitrogen, optimally an N-methanesulfonyl moiet
Calbindin D28K-containing neurons, and not HSP70-expressing neurons, are more resistant to HIV-1 envelope (gp120) toxicity in cortical cell cultures.: J Neurosci Res. 1995 Oct 1;42(2):252-8. Unique Identifier : AIDSLINE MED/96122605; Diop AG; Lesort M; Esclaire F; Dumas M; Hugon J; Cellular Neurobiology Unit-Laboratory of Histology, Medical; Institute of Cellular and Molecular Biology, Faculty of Medicine,; Limoges, France.; HIV-1-associated cognitive/motor complex is one of the major neurological complications of AIDS and is associated with neuronal loss. Gp120, the HIV envelope protein, is toxic for neurons in cultures and produces a rise in intracytosolic calcium. This neurotoxicity is dose-dependent and time-dependent. We evaluated th
Prenatal and neonatal HIV testing [letter]: JAMA. 1996 Feb 7;275(5):357-8. Unique Identifier : AIDSLINE MED/96163385; Fischer CT
HIV and physical examination skills [letter]: JAMA. 1996 Feb 7;275(5):361. Unique Identifier : AIDSLINE MED/96163393; Buhl WR
Differential effects of gonadectomy on thymic stromal cells in promoting T cell differentiation in mice.: Mech Ageing Dev. 1995 Jul 14;81(2-3):107-17. Unique Identifier : AIDSLINE MED/96171086; Utsuyama M; Hirokawa K; Mancini C; Brunelli R; Leter G; Doria G; Department of Immunopathology, Tokyo Metropolitan Institute of; Gerontology, Japan.; Twenty-six week-old BDF1 mice were gonadectomized and grafted with thymus from irradiated (8.5 Gy) newborn, 6-week-old, or 26-week-old mice. One month later, grafted thymuses were recovered and examined in terms of thymocyte numbers, subpopulations and proliferative responses to Concananavlin A (Con A). The growth of
Undisclosed prevalent HIV disease in district general hospitals in London [letter]: Lancet. 1996 Feb 3;347(8997):327-8. Unique Identifier : AIDSLINE MED/96158658; Gore SM; Bird AG; Brettle RP
HIV-1 subtype B in west Africa [letter]: Lancet. 1996 Feb 3;347(8997):328. Unique Identifier : AIDSLINE MED/96158659; Ariyoshi K; Cheingsong-Popov R; Wilkins A; Corrah T; Weber J; Whittle H
CD4 lymphopenia in very elderly people [letter]: Lancet. 1996 Feb 3;347(8997):328-9. Unique Identifier : AIDSLINE MED/96158660; Rae IM; Alexander HD; Crockard AD; Morris TC
Programs need to educate youth about drugs, sex, and HIV [letter]: Md Med J. 1996 Jan;45(1):22. Unique Identifier : AIDSLINE MED/96148241; Berger RS
Development of a knowledge-based electronic patient record.: MD Comput. 1996 Jan-Feb;13(1):46-54, 63. Unique Identifier : AIDSLINE MED/96166413; Safran C; Rind DM; Sands DZ; Davis RB; Wald J; Slack WV; Department of Medicine, Beth Israel Hospital, Boston, MA, USA.; To help clinicians care for patients with HIV infection, we developed an interactive knowledge-based electronic patient record that integrates rule-based decision support and full-text information retrieval with an online patient record. This highly interactive clinical workstation now allows the clinicians at a large
Low occurrence of arthritic manifestations in patients with pulmonary tuberculosis. T cell subsets and humoral studies.: Mem Inst Oswaldo Cruz. 1995 Sep-Oct;90(5):623-8. Unique Identifier : AIDSLINE MED/96092394; Dlugovitzky D; Torres A; Hourquescos MC; Svetaz MJ; Quagliato N; Valentini E; Amigot B; Molteni O; Bottasso O; Catedra de Microbiologia, Facultad de Ciencias Medicas,; Universidad Nacional de Rosario, Argentina.; Given the suspected role of mycobacteria in the establishment of disorders with an autoimmune background and joint damage, a study was conducted to analyze whether rheumatic symptoms were likely to be present in tuberculosis (TB) patients. To this end, 330 patients with a bacteriologic confirmation of tuberculosis wer
Overproduction, purification, and diagnostic use of the recombinant HIV-1 Gag proteins, the precursor protein p55 and the processed products p17, p24, and p15.: Microbiol Immunol. 1995;39(7):473-83. Unique Identifier : AIDSLINE MED/96025417; Saito A; Morimoto M; Ohara T; Takamizawa A; Nakata A; Shinagawa H; Department of Molecular Microbiology, Osaka University, Japan.; HIV-1 Gag protein precursor p55, and its processed products, p17, p24, and p15 were overproduced in Escherichia coli and purified to near homogeneity. To study the antigenic properties and the potentiality as the diagnostic and prognostic reagents, varying amounts of the purified Gag proteins were dotted onto the poly
Sequential involvement of NK cells and CD8+ T cells in granuloma formation of Rhodococcus aurantiacus-infected mice.: Microbiol Immunol. 1995;39(7):499-507. Unique Identifier : AIDSLINE MED/96025420; Asano M; Nakane A; Kohanawa M; Minagawa T; Department of Microbiology, Hokkaido University School of; Medicine, Japan.; We investigated the effect of in vivo administration of antibodies against T-cell subsets and natural killer (NK) cells on endogenous gamma interferon (IFN-gamma) production and granuloma formation in Rhodococcus aurantiacus-infected mice. High titers of endogenous IFN-gamma were detected in the extracts of the livers
TCR-independent induction of low responsiveness by chemically fixed cells in alloreactive CTL clones and its prevention through cognate cell-cell interaction.: Microbiol Immunol. 1995;39(7):509-15. Unique Identifier : AIDSLINE MED/96025421; Lwin T; Nakashima I; Nagase F; Department of Immunology, Nagoya University School of Medicine,; Aichi, Japan.; We established BALB/c-derived CD8+ CTL clones D2-22 (V beta 6+), D2-23 (V beta 8+) and D2-24 (V beta 8+) specific for B10.D2 minor H antigen. D2-22 and D2-23 proliferated without producing IL-2 in response to X-ray-irradiated antigenic cells, Con A, aCD3, PMA and IL-2.
From pseudocholinesterase to human immunodeficiency virus.: Med Hypotheses. 1995 Sep;45(3):225-6. Unique Identifier : AIDSLINE MED/96130661; Madhavankutty K; Shyamasundar K; Andrews W; Department of Pediatrics, Faculty of Medicine, Memorial; University of Newfoundland, Canada.; Pseudocholinesterase is a protein for which no function exists in mammals including human beings. To date, no substrate has been identified for this enzyme . Involvement of this protein in the aetiopathogenesis of many diseases, such as hyperlipoproteinaemia, is still actively debated. Here, we propose a theoretical
Con A cytotoxicity: a model for the study of key signaling steps leading to lymphocyte apoptosis in AIDS?: Med Hypotheses. 1995 Sep;45(3):311-5. Unique Identifier : AIDSLINE MED/96130676; Pitts OM; Lymphocytes respond to mitogens, viruses and other activation agents with hydrogen peroxide or reactive oxygen bursts which may originate at or near the cell membrane. It has been shown that a very small increase in the ratio of Con A cells results in a rapid switchover from mitogenicity to cytotoxicity. It is hypothe
Primary HIV infection.: Med J Aust. 1996 Jan 15;164(2):105-6. Unique Identifier : AIDSLINE MED/96158827; Carr A; Boyle MJ; HIV Medicine Unit and Centre for Immunology, St Vincent's; Hospital, Sydney, NSW.; The most important principle in managing primary HIV infection is not to miss the diagnosis. It presents an early opportunity for counselling and education aimed at maximising quality of life and minimising the risk of transmitting HIV (particularly high during the viraemia of primary infection).
Early HIV-induced immune deficiency.: Med J Aust. 1996 Jan 15;164(2):107-8. Unique Identifier : AIDSLINE MED/96158828; Kelleher AD; Orth D; Centre for Immunology, St Vincent's Hospital, Sydney, NSW.; From the resolution of primary infection until the CD4 cell count falls below 500/microL, people with HIV are usually functioning at their normal capacity physically, mentally and socially. However, HIV is replicating actively within lymph nodes during this period of early immune deficiency. It is important to determi
HIV and intermediate immune deficiency.: Med J Aust. 1996 Jan 15;164(2):109-10. Unique Identifier : AIDSLINE MED/96158829; Adelstein S; McKnight I; Pethebridge AM; Department of Clinical Immunology, Royal Prince Alfred Hospital,; Sydney, NSW.; Intermediate immune deficiency is defined by a CD4 cell count between 500/microL and 200/microL. This phase is one of increasing therapeutic intervention, mostly for minor infections of skin and mucous membranes and mostly manageable within general practice. Most people with HIV begin antiretroviral therapy during thi
HIV and advanced immune deficiency.: Med J Aust. 1996 Jan 15;164(2):111-2. Unique Identifier : AIDSLINE MED/96158830; Marriott D; McMurchie M; Department of Clinical Microbiology and Infectious Diseases, St; Vincent's Hospital, Sydney, NSW.; Advanced immune deficiency is defined as a CD4 cell count below 200/microL. This phase is marked by considerable medical intervention requiring close coordination between general practitioner and specialist, with the goal of minimising the patient s time in hospital. The patient must be assisted with the psychological
HTLV-I in Australia and Oceania: long-term resident or recent immigrant?: Med J Aust. 1996 Jan 15;164(2):84-6. Unique Identifier : AIDSLINE MED/96158820; Doherty RR; Department of Paediatrics, Faculty of Medicine, Monash; University, Melbourne, VIC. richard.doherty@med.monash.edu.au; Human T-cell lymphotropic virus type I (HTLV-I) has a worldwide distribution; infection rates of up to 14% have been found in Aboriginal communities, but there is little evidence of typical HTLV-I-associated disease. The strains among Australian Aboriginals and Melanesians are more closely related to each other at the
HIV medicine in the mainstream.: Med J Aust. 1996 Jan 15;164(2):97-8. Unique Identifier : AIDSLINE MED/96158825; Stewart GJ; Department of Clinical Immunology and Allergy, Westmead Hospital,; Sydney, NSW.; After more than a decade of special treatment, HIV medicine is ready to enter the mainstream of medical practice in developed countries. Access to a conveniently located, well informed, primary care doctor who works well with an appropriate specialist is the cornerstone of best medical care for chronic illness, includ
Strategies of care in managing HIV.: Med J Aust. 1996 Jan 15;164(2):99-104. Unique Identifier : AIDSLINE MED/96158826; Stewart GJ; Irvine SS; Scott M; Kelleher AD; Marriott DJ; McKnight I; Pethebridge AM; Wodak A; Ziegler J; Department of Clinical Immunology and Allergy, Westmead Hospital,; Sydney, NSW.; Apply the science, use a team approach, help patients to promote their own health, ensure access to support and accept a public health role. These are the practical lessons of our experience in HIV medicine.
Variable efficiency of three primer pairs for the diagnosis of Pneumocystis carinii pneumonia by the polymerase chain reaction.: Mol Cell Probes. 1995 Oct;9(5):333-40. Unique Identifier : AIDSLINE MED/96123416; De Luca A; Tamburrini E; Ortona E; Mencarini P; Margutti P; Antinori A; Visconti E; Siracusano A; Institute of Clinical Infectious Diseases, Catholic University,; Rome, Italy.; The efficiency of three different primer pairs, complementary to different Pneumocystis carinii DNA regions, was compared in the polymerase chain reaction (PCR) for the diagnosis of Pneumocystis carinii pneumonia (PCP) on bronchoalveolar fluid (BALF) from patients with AIDS. PCR coupled with dot-blot hybridization (BL
Internal controls as performance monitors and quantitative standards in the detection by polymerase chain reaction of herpes simplex virus and cytomegalovirus in clinical specimens.: Mol Cell Probes. 1995 Oct;9(5):347-56. Unique Identifier : AIDSLINE GENBANK/U06236; Nash KA; Klein JS; Inderlied CB; Department of Pathology, Childrens Hospital Los Angeles, CA; 90027, USA.; Internal controls (IC) were produced and characterized for an HSV and a CMV PCR assay which serve both as test performance monitors and as quantitative standards. In each of the PCR assays the IC and native targets were amplified with equal efficiency and were d
Design and evaluation of new, highly sensitive and specific primers for polymerase chain reaction detection of HIV-1 infected primary lymphocytes.: Mol Cell Probes. 1995 Oct;9(5):373. Unique Identifier : AIDSLINE MED/96123422; Fransen K; Zhong P; De Beenhouwer H; Carpels G; Peeters M; Louwagie J; Janssens W; Piot P; van der Groen G
Fungaemia in hospitalized patients.: Mycoses. 1995 Sep-Oct;38(9-10):385-7. Unique Identifier : AIDSLINE MED/96135574; Perduca M; Marangoni E; Guanziroli A; Romero E; Filice G; Institute of Microbiology, University of Pavia, Italy.; At various clinics of IRCCS S. Matteo Hospital, Pavia, Italy , 269 blood cultures recovered from immunocompromised patients over 4 years have been examined mycologically. Of the 269 cultures, 101 were from HIV-infected patients and five were from cardiac transplant recipients. Of the
Deoxyglucose uptake by mouse astrocytes: effects of temperature and retrovirus infection.: Neurochem Res. 1995 Sep;20(9):1013-20. Unique Identifier : AIDSLINE MED/96117160; Vann JM; Goldman AJ; Szurek PF; Brooks BR; Neurology Service, William S. Middleton Memorial Veterans; Hospital, Madison, WI 53705-2286, USA.; Deoxyglucose uptake by FVB/N mouse astrocytes was studied before and after infection by ts1 retrovirus which causes a neurodegenerative disease in mice similar to HIV-1 encephalopathy in man. The Michaelis-Menten kinetic parameters, Km and Vmax, of 2-deoxy-D-glucose uptake by brain and cerebellar astrocytes were measu
Immunoscintigraphy with a 99Tcm-labelled anti-granulocyte monoclonal antibody in patients with human immunodeficiency virus infection and AIDS.: Nucl Med Commun. 1995 Oct;16(10):838-45. Unique Identifier : AIDSLINE MED/96123947; Prvulovich EM; Miller RF; Costa DC; Severn A; Corbett E; Bomanji J; Becker WS; Ell PJ; Institute of Nuclear Medicine, University College London Medical; School, UK.; The value of immunoscintigraphy with technetium-99m (99Tcm) labelled anti-granulocyte monoclonal antibody (BW250/183) was studied prospectively in human immunodeficiency virus (HIV-1) antibody-positive patients presenting with fever without localizing symptoms or signs. Twenty-three studies were performed in 23 patien
Cytomegalovirus optic neuritis: characteristics, therapy and survival.: Ophthalmologica. 1995;209(5):260-6. Unique Identifier : AIDSLINE MED/96141238; Mansor AM; Li HK; Department of Ophthamology, University of Texas Medical Branch,; Galveston 77555-0787, USA.; Little is known about the natural history of cytomegalovirus ( CMV ) optic neuritis in the acquired immunodeficiency syndrome. We analyzed the clinical course of CMV optic neuritis in 30 consecutive subjects (35 eyes), and comp
HIV-tat protein is a heparin-binding angiogenic growth factor.: Oncogene. 1996 Jan 18;12(2):289-97. Unique Identifier : AIDSLINE PIR/A23553; Albini A; Benelli R; Presta M; Rusnati M; Ziche M; Rubartelli A; Paglialunga G; Bussolino F; Noonan D; Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy.; Transgenic animal studies have linked the expression of the HIV-1 tat gene to the appearance of Kaposi s sarcoma (KS)-like lesions. We have recently shown that recombinant tat is angiogenic in vivo, and that tat angiogenic response is enhanced by heparin. Also in the rabbit cornea model, recombinant HIV-1 tat alone is
The Gag-Myb-Ets fusion oncogene alters the apoptotic response and growth factor dependence of interleukin-3 dependent murine cells.: Oncogene. 1996 Jan 18;12(2):337-44. Unique Identifier : AIDSLINE MED/96152899; Athanasiou M; Mavrothalassitis GJ; Yuan CC; Blair DG; Laboratory of Cellular Biochemistry, SAIC Frederick, Maryland,; USA.; Expression of the avian E26-derived Gag-Myb-Ets fusion oncogene in interleukin-3(IL3)-dependent murine hematopoietic cell lines results in a pattern of cell line dependent changes in growth factor-induced proliferation and apoptosis. A drug-selectable retrovirus expressing p135Gag-Myb-Ets induced an erythropoietin(Epo
Microsporidial rhinosinusitis: is this the next pathogen to infect the sinuses of the immunocompromised host?: Otolaryngol Head Neck Surg. 1996 Jan;114(1):137-9. Unique Identifier : AIDSLINE MED/96155473; Josephson GD; Sarlin J; Reidy J; Pincus R; Department of Otolaryngology-Head and Neck Surgery, New York Eye; and Ear Infirmary, New York, NY 10003, USA.
HIV-related Pneumocystis carinii thyroiditis: a unique case and literature review.: Otolaryngol Head Neck Surg. 1996 Jan;114(1):158-61. Unique Identifier : AIDSLINE MED/96155477; Danahey DG; Kelly DR; Forrest LA; Department of Otolaryngology-Head and Neck Surgery, Ohio State; University College of Medicine, Columbus 43210, USA.
[HCV antibodies in hemodialyzed patients in Tunisia]: Pathol Biol (Paris). 1995 Sep;43(7):581-3. Unique Identifier : AIDSLINE MED/96146822; Hmida S; Mojaat N; Chaouchi E; Mahjoub T; Khlass B; Abid S; Boukef K; Centre National de Transfusion Sanguine, TUNIS, Tunisie.; The prevalence of seropositivity to Hepatitis C and B virus and HIV infection in Haemodialysis patients was assessed in sera from 235 patients from 6 dialysis units in Tunisia . Anti-HCV antibodies were found in 106 patients (45.10%), the hepatitis B surface antigene was found in 1
Commonly asked questions regarding infections in neonates.: Pediatr Ann. 1995 Nov;24(11):583-6, 589-91. Unique Identifier : AIDSLINE MED/96157932; Calhoun DA; Christensen RD; Department of Pediatrics, University of Florida College of; Medicine, Gainesville 32610, USA.
Blood management: facts and fictions.: Orthopedics. 1995 Sep;18(9):836-7. Unique Identifier : AIDSLINE MED/96100535; Head WC; Emerson RH Jr; Hillyard JM; Texas Center for Joint Replacement, Plano 75093, USA.
Human immunodeficiency virus type 1 infection alters chemokine beta peptide expression in human monocytes: implications for recruitment of leukocytes into brain and lymph nodes.: Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):700-4. Unique Identifier : AIDSLINE MED/96149367; Schmidtmayerova H; Nottet HS; Nuovo G; Raabe T; Flanagan CR; Dubrovsky L; Gendelman HE; Cerami A; Bukrinsky M; Sherry B; Picower Institute for Medical Research, Manhasset, NY 11030, USA.; Two chemokine (chemoattractant cytokines) beta peptides, macrophage inflammatory proteins 1 alpha and 1 beta (MIP-1 alpha and MIP-1 beta), were induced in human monocyte cultures following infection with the human immunodeficiency virus type 1 (HIV-1). Induction depended on productive viral infection: not only did the
Intracerebral injection of human immunodeficiency virus type 1 coat protein gp120 differentially affects the expression of nerve growth factor and nitric oxide synthase in the hippocampus of rat.: Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):928-33. Unique Identifier : AIDSLINE MED/96149412; Bagetta G; Corasaniti MT; Aloe L; Berliocchi L; Costa N; Finazzi-Agro A; Nistico G; Department of Biology, Mondino-Tor Vergata Center for; Experimental Neurobiology, Rome, Italy.; We have studied the neuropathological characteristics of the brain of rats receiving daily intracerebroventricular administration of freshly dissolved human immunodeficiency virus type 1 recombinant protein gp120 (100 ng per rat per day) given for up to 14 days. Histological examination of serial brain sections reveal
Synthesis and biological activity of 1,2,4-triazinotriazinone derivatives.: Pharmazie. 1995 Nov;50(11):726-9. Unique Identifier : AIDSLINE MED/96128321; Abdel-Halim AM; el-Gendy Z; Abdel-Rahman RM; Department of Chemistry, Faculty of Education,; Ain-Shams-University, Roxy, Cairo, Egypt.; The synthesis of 1,2,4-triazines bearing a 1,2,4-triazinone moiety and of 1,2,4-triazolo[4,3-b]-1,2,4-triazonones have been achieved by reaction of 1,6-dihydro-3-hydrazino-6-spiro- (9-fluorenyl)-1,2,4-triazin-5(4H)-one with various oxo- and halo-compounds. Structures of the products have been deduced by elemental anal
OTA swan song has many verses [news]: Public Health Rep. 1995 Nov-Dec;110(6):651-2. Unique Identifier : AIDSLINE MED/96158885
Levels and predictors of HIV risk behavior among women in low-income public housing developments.: Public Health Rep. 1995 Nov-Dec;110(6):707-13. Unique Identifier : AIDSLINE MED/96158901; Sikkema KJ; Koob JJ; Cargill VC; Kelly JA; Desiderato LL; Roffman RA; Norman AD; Shabazz M; Copeland C; Winett RA; et al; Center for AIDS Intervention Research (CAIR), Medical College of; Wisconsin, Milwaukee 53226, USA.; The prevalence of increases in human immunodeficiency virus infection and illness rates among urban disadvantaged women underscore the urgent need for acquired immunodeficiency syndrome prevention interventions for high-risk women. Few studies, however, have examined the factors contributing to risk in this population
Consistency in self-reports of HIV testing: longitudinal findings from the National AIDS Behavioral Surveys.: Public Health Rep. 1995 Nov-Dec;110(6):749-53. Unique Identifier : AIDSLINE MED/96158907; Phillips KA; Catania JA; Center for AIDS Prevention Studies, School of Medicine,; University of California, San Francisco 94105, USA.; This paper assesses consistency in self-reports of human immunodeficiency virus testing using two waves of longitudinal data from a large, national probability survey, the National AIDS Behavioral Survey. Of those reporting at Wave I that they had been tested for reasons other than blood donation, 18 percent reported
Endobronchial non-Hodgkin's lymphoma in an AIDS patient.: Respir Med. 1995 Nov;89(10):697-9. Unique Identifier : AIDSLINE MED/96150467; el-Solh A; Ameen K; Sherif S; Department of Medicine, State University of New York at Buffalo; 14215, USA.
[Effect of primary prevention of Pneumocystis carinii pneumonia on the inaugural clinical and biological presentation of AIDS: 624 cases (Aquitaine Cohort, 1985-1994)]: Rev Med Interne. 1995;16(11):815-7. Unique Identifier : AIDSLINE MED/96145680; Morlat P; Hubert JB; Chene G; Buisson M; Paty MC; Lasseur C; Constans J; Bernard N; Beylot J; Service de medecine interne, hopital Saint-Andre, Bordeaux,; France.; In a cohort of HIV-infected patients, this study compares the clinical and immunological features at the time of AIDS diagnosis of patients who either received primary Pneumocystis carinii prophylaxis (P+; n = 335) or who did not (P-; n = 289). Frequency of P carinii pneumonia was lower in P+ than in P- patients (14.9
[New methods of quantification of the viral load in HIV infection]: Rev Med Interne. 1995;16(12):976-8. Unique Identifier : AIDSLINE MED/96145710; Agut H; Calvez V; Laboratoire de virologie du CERVI, CNRS EP 57, CHU; Pitie-Salpetriere, Paris, France.
[Immunopathological mechanisms of HIV infection]: Rev Med Interne. 1995;16 Suppl 3:303s-307s. Unique Identifier : AIDSLINE MED/96145673; Gluckman JC; Hopital de la Pitie-Salpetriere, Paris, France.
[Immunomodulator treatments in HIV infection: rational bases and therapeutic prospects]: Rev Med Interne. 1995;16 Suppl 3:308s-312s. Unique Identifier : AIDSLINE MED/96145674; Durant J; Dellamonica P; Service des maladies infectieuses et tropicales, hopital; l'Archet, Nice, France.
[Prevention of opportunistic infections in HIV infection]: Rev Med Interne. 1995;16 Suppl 3:315s-319s. Unique Identifier : AIDSLINE MED/96145675; Pesce A; Service de medecine interne, hopital de Cimiez, Nice, France.
[Infectious diseases during pregnancy (II). Diagnosis, prevention, fetal risks, therapeutic consequences]: Rev Prat. 1995 Nov 1;45(17):2215-37. Unique Identifier : AIDSLINE MED/96146164; Giovangrandi Y; Costa JM; Malka D; Belein V; Universite Rene-Descartes, Paris V, Laboratoire d'immunologie; des tumeurs URA 1484, CNRS.
[Vaginal and intrauterine contraception]: Rev Prat. 1995 Dec 1;45(19):2407-15. Unique Identifier : AIDSLINE MED/96148041; Serfaty D; Centre de regulation des naissances Hopital, Saint-Louis,; Paris.; Vaginal contraception (condom, diaphragm and spermicide in pessary, tablet, jelly, cream, or sponge form) have been little used in France and generally in Europe since the advent of modern contraception with the pill and the intrauterine contraceptive device. The former methods, wh
[Choice and follow-up of contraception without risk factor]: Rev Prat. 1995 Dec 1;45(19):2417-21. Unique Identifier : AIDSLINE MED/96148042; Drapier-Faure E; Departement de gynecologie, oncologie gynecologique,; senologie medecine de la reproduction Hopital Edouard-Herriot,; Lyon.; Every young healthy and truly informed woman may use any contraceptive method. Teenagers have to avoid not only pregnancy but also AIDS and other sexually transmitted diseases. Therefore they may use condoms when aware of postcoital contraception or must use both condoms and oral contraceptives. Non smoker women over
[Problems in the diagnosis and therapy of lymph node tuberculosis in HIV-negative patients]: Schweiz Med Wochenschr. 1995 Dec 26;125(51-52):2511-7. Unique Identifier : AIDSLINE MED/96143633; Canova CR; Kuhn M; Reinhart WH; Medizinische Klinik, Kantonsspital Chur.; Tuberculosis is the world s foremost cause of death from a single infectious agent in adults. During the past decade the nature and magnitude of the problem of tuberculosis have dramatically changed. Much of what physicians have learned about this disease is no longer true and tuberculosis has become a new entity. Mig
Oxidative stress and apoptosis in HIV infection [letter]: Science. 1996 Feb 2;271(5249):582-3. Unique Identifier : AIDSLINE MED/96165380; Baier-Bitterlich G; Wachter H; Fuchs D
Overhauling AIDS research: views from the community [news]: Science. 1996 Feb 2;271(5249):590-1. Unique Identifier : AIDSLINE MED/96165382; Cohen J
Plasma viral load, CD4+ cell counts, and HIV-1 production by cells [letter]: Science. 1996 Feb 2;271(5249):670-1. Unique Identifier : AIDSLINE MED/96165398; Levy JA; Ramachandran B; Barker E; Guthrie J; Elbeik T
[An organized sector mobilized against AIDS]: Servir. 1995 Sep-Oct;43(5):270-2. Unique Identifier : AIDSLINE MED/96155422; Mehra-Kerpelman K
Cells and cytokines in the pathogenesis of MAIDS, a retrovirus-induced immunodeficiency syndrome of mice.: Springer Semin Immunopathol. 1995;17(2-3):231-45. Unique Identifier : AIDSLINE MED/96124353; Morse HC 3rd; Giese N; Morawetz R; Tang Y; Gazzinelli R; Kim WK; Chattopadhyay S; Hartley JW; Laboratory of Immunopathology, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892-0760, USA.
[The value of conventionally fractionated radiotherapy in the local treatment of HIV-related Kaposi's sarcoma]: Strahlenther Onkol. 1995 Oct;171(10):594-9. Unique Identifier : AIDSLINE MED/96163581; Saran F; Adamietz IA; Mose S; Thilmann C; Bottcher HD; Abteilung fur Strahlentherapie und Onkologie,; Johann-Wolfgang-Goethe-Universitat, Frankfurt am Main.; BACKGROUND: During the course of AIDS, 25 to 44% of homosexual patients infected with the human immunodeficiency virus develop Kaposi s sarcoma. Main manifestation is the skin. Response rates of 80 to 100% can be achieved with total dosage up to 50 Gy. Nevertheless, remissions can also be attained with 20 Gy of fracti
[The clinical manifestations of HIV infection during seroconversion]: Ter Arkh. 1995;67(11):24-7. Unique Identifier : AIDSLINE MED/96151288; Kravchenko AV; Iurin OG; Buravtsova EV; Pankova GIu; Serebrovskaia LV; Galina MV; Roslyi IM; Pokrovskii VV; 21 seroconversion HIV-infected subjects have been examined. 16 of them presented with acute symptoms. The disease in the period of seroconversion manifested with fever, weakness, headache, pain in the throat, enlargement of peripheral lymph nodes, polymorphous eruption. Typical mononucleosis-like syndrome occurred in
[Retroviruses in human infectious pathology]: Ter Arkh. 1995;67(11):59-61. Unique Identifier : AIDSLINE MED/96151300; Pokrovskii VI; Godovannyi BA; Isaevich LV
[Occurrence of anterior uveitis in a HIV patient treated with rifabutin, ethambutol, clarithromycin (letter)]: Therapie. 1995 Sep-Oct;50(5):482-3. Unique Identifier : AIDSLINE MED/96146148; Pinzani V; Mauboussin JM; Berthault C; Aubry I; Balmes P; Blayac JP
[Therapy and prognosis of tuberculosis]: Versicherungsmedizin. 1995 Dec 1;47(6):212-6. Unique Identifier : AIDSLINE MED/96119093; Fischer B; Ferlinz R; III Medizinischen Klinik und Poliklinik, Univ. Mainz.; Treatment and prognosis of tuberculosis. Worldwide the so-called short-course chemotherapy has become the standard treatment for tuberculosis. The 6-month regimen consists of isoniazid, rifampin, and pyrazinamid given for 2 month followed by isoniazid and rifampin for 4 month. Ethambutol or streptomycin is added in th
Development and application of an antibody ELISA for the marker protein of ovine pulmonary carcinoma.: Vet Immunol Immunopathol. 1995 Aug;47(3-4):323-31. Unique Identifier : AIDSLINE MED/96016705; Kwang J; Keen J; Rosati S; Tolari F; USDA, ARS, US Meat Animal Research Center, Clay Center, NE 68933,; USA.; Ovine pulmonary carcinoma (OPC) is a contagious pulmonary neoplasia with a suspected retroviral etiology. The major core protein (P27) of the putative OPC virus cross-reacts with antibodies to P27 of the Mason- Pfizer monkey virus (MPMV), a type-D retrovirus. This serologic
Molecular pathogenesis of AIDS-related lymphomas.: Adv Cancer Res. 1995;67:113-53. Unique Identifier : AIDSLINE MED/96126126; Gaidano G; Dalla-Favera R; Dipartimento di Scienze Biomediche e Oncologia Umana, Universita; di Torino, Ospedale San Luigi Gonzaga, Turin, Italy.
Detection and differential diagnosis of pulmonary infections and tumors in patients with AIDS: value of chest radiography versus CT.: AJR Am J Roentgenol. 1996 Jan;166(1):15-9. Unique Identifier : AIDSLINE MED/96110487; Kang EY; Staples CA; McGuinness G; Primack SL; Muller NL; Department of Radiology, University of British Columbia,; Vancouver, Canada.; OBJECTIVE. The purpose of this study was to compare the sensitivity and specificity of chest radiography with those of CT in the detection of pulmonary infections and tumors in patients with AIDS. MATERIALS AND METHODS. The study was retrospective and included the radiographs and CT scans of 139 patients. Eighty-nine
Cystic thymic hyperplasia in a child with HIV infection: imaging findings.: AJR Am J Roentgenol. 1996 Jan;166(1):171-2. Unique Identifier : AIDSLINE MED/96110520; Mercado-Deane MG; Sabio H; Burton EM; Hatley R; Department of Radiology, Medical College of Georgia, Augusta; 30912, USA.
Concurrent thrombotic thrombocytopenic purpura and immune thrombocytopenic purpura in an HIV-positive patient: case report and review of the literature.: Am J Hematol. 1996 Jan;51(1):73-8. Unique Identifier : AIDSLINE MED/96159001; Yospur LS; Sun NC; Figueroa P; Niihara Y; Department of Pathology, Harbor-UCLA Medical Center, Torrance; 90509, USA.; Immune thrombocytopenic purpura (ITP) and thrombotic thrombocytopenic purpura (TTP) have each been associated with HIV infection. Sequential occurrence of these two diseases with a disease-free interval has been occasionally reported in the literature, whereas simultaneous manifestations of these two diseases have not
Sequence analysis of HTLV-1 provirus associated with adult T-cell leukemia/lymphoma in Hong Kong [letter]: Am J Hematol. 1996 Jan;51(1):94-5. Unique Identifier : AIDSLINE MED/96159006; Chan WP; Liang R
The need for anonymous genetic counseling and testing.: Am J Hum Genet. 1996 Feb;58(2):393-7. Unique Identifier : AIDSLINE MED/96152136; Mehlman MJ; Kodish ED; Whitehouse P; Zinn AB; Sollitto S; Berger J; Chiao EJ; Dosick MS; Cassidy SB; Law-Medicine Center, Case Western Reserve University School of; Law, Cleveland, OH, USA.; Concerns are mounting about the risks of genetic discrimination resulting from the release of predictive and presymptomatic genetic test results to employers, insurers, and others. The ability to keep this information confidential is questionable, particularly in view of the expansion of electronic medical databases.
The changing epidemiology of foodborne diseases.: Am J Med Sci. 1996 Jan;311(1):23-9. Unique Identifier : AIDSLINE MED/96164688; Altekruse SF; Swerdlow DL; Centers for Disease Control, Atlanta, Georgia 30333, USA.; The epidemiology of foodborne diseases in the United States have changed in recent decades as new pathogens have emerged, the food supply has changed, and the number of people with heightened susceptibility to foodborne diseases has increased. Emerging pathogens are those that have rec
Simian immunodeficiency virus variants: threat of new lentiviruses.: Am J Med Sci. 1996 Jan;311(1):30-3. Unique Identifier : AIDSLINE MED/96164689; McClure HM; Novembre FJ; Yerkes Regional Primate Research Center, Emory University,; Atlanta, Georgia 30322, USA.; Infection in humans with the lentivirus HIV-1 typically results in the development of a chronic disease state characterized by the slow decline of CD4+ lymphocytes, the development of immunosuppression, and the development of opportunistic infections, ultimately leading to death. Although the average course of disease
Uptake of human immunodeficiency virus envelope protein gp120 by human trophoblast in culture.: Am J Obstet Gynecol. 1996 Jan;174(1 Pt 1):49-54. Unique Identifier : AIDSLINE MED/96148667; Esterman AL; Finlay TH; Lee JD; Dancis J; Department of Pediatrics, New York University Medical Center, NY; 10016, USA.; OBJECTIVE: Our purpose was to determine whether human trophoblast has a cell surface CD4 antigen that will bind to gp120, the envelope protein of human immunodeficiency virus. STUDY DESIGN: Uptake of iodine 125-labeled gp120 by trophoblast in culture was measured. Particular attention was paid to technical details tha
Ultrastructural findings in the vestibular end-organs of AIDS cases.: Am J Otol. 1995 Mar;16(2):140-5. Unique Identifier : AIDSLINE MED/96149069; Pappas DG Jr; Roland JT Jr; Lim J; Lai A; Hillman DE; Department of Otolaryngology, NYU Medical Center, NY 10016, USA.; Neurotologic manifestations are apparent in human immunodeficiency virus (HIV) infection, but are poorly understood. Symptoms related to the vestibular system include episodes of vertigo, imbalance, ataxia, and nausea. Although patients present more often with hearing impairment, vestibular complaints are described an
In situ polymerase chain reaction technique revealed by flow cytometry as a tool for gene detection.: Anal Biochem. 1995 Jul 1;228(2):252-8. Unique Identifier : AIDSLINE MED/96171045; Gibellini D; Zauli G; Re MC; Furlini G; Lolli S; Bassini A; Celeghini C; La Placa M; Institute of Microbiology, University of Bologna, Italy.; We report a methodology for detecting specific DNA sequences directly inside cells, combining in situ PCR and flow cytometry. This technique is based on in situ PCR performed in the presence of digoxigenin-labeled dUTP to obtain a digoxigenin-labeled amplicon, which is then revealed by an anti-digoxigenin polyclonal a
HIV-1 protease specificity derived from a complex mixture of synthetic substrates.: Anal Biochem. 1995 Jul 1;228(2):259-66. Unique Identifier : AIDSLINE MED/96171046; Kassel DB; Green MD; Wehbie RS; Swanstrom R; Berman J; Glaxo-Wellcome Research Institute, Research Triangle Park, North; Carolina 27709, USA.; A rapid and semiquantitative method is described for determining the relative kcat/Km for individual peptides in defined substrate mixtures. The method utilizes electrospray ionization/mass spectrometry alone to semiquantitatively determine relative peptide substrate turnover rates. Unlike previous studies, in which c
[Lymphoma with skin manifestations in HIV infection: 8 cases]: Ann Dermatol Venereol. 1995;122(8):488-93. Unique Identifier : AIDSLINE MED/96146750; Esteve E; Bagot M; Grange F; Beylot-Barry M; D'Incan M; Vaillant L; Laroche L; Joly P; Pradinaud R; Vergier B; et al; Service de Dermatologie, Hopital Robert-Debre, Reims.; INTRODUCTION. Cutaneous lymphomas occurring in HIV infection are a rare disease. Most of them are high grade lymphomas with fulminant course and poor prognosis. OBJECTIVE. Evaluate clinical and histological aspects as well as immunophenotype and evolution of these lymphomas. PATIENTS AND METHODS. Eight patients with H
[Local treatments of AIDS-related Kaposi disease]: Ann Dermatol Venereol. 1995;122(8):551-7. Unique Identifier : AIDSLINE MED/96146767; Saiag P; Brunet H; Fortier-Beaulieu M; Service de Dermatologie, CHU Ambroise-Pare,; Boulogne-Billancourt.
Immunological alterations induced by adjuvant treatment of postoperative colon carcinoma Duke's B or C with levamisole in combination with 5-FU.: Anticancer Res. 1995 Sep-Oct;15(5B):2271-7. Unique Identifier : AIDSLINE MED/96152477; De Brabander M; Vandebroek J; Wassenaar H; De Cree J; Baisier A; Demoen B; De Ridder R; Jagers E; Roels V; Vogels O; et al; Clinical Research Unit St. Bartholomeus, Jan Palftjn Hospital,; Merksem, Belgium.; BACKGROUND: Postoperative 5-FU combined with levamisole increases 5 year survival in colon cancer patients (Duke C) by 30% (1). In order to investigate the potential immunological mechanism, we determined lymphocyte subtypes and markers of immune activation in 22 patients before and during one year of postoperative ad
Serologic response to treatment of syphilis in patients with HIV infection.: Arch Intern Med. 1996 Feb 12;156(3):321-5. Unique Identifier : AIDSLINE MED/96163313; Yinnon AM; Coury-Doniger P; Polito R; Reichman RC; Infectious Diseases Unit, University of Rochester Medical Center,; NY, USA.; BACKGROUND: Much controversy exists concerning the manifestations, therapy, and response to treatment of syphilis in patients coinfected with the human immunodeficiency virus (HIV). OBJECTIVE: To assess the effect of HIV infection on the serologic response to treatment of patients with syphilis. METHODS: Sixty-four HI
Interferon and tumor necrosis factor responses of HIV+ patients as markers for monitoring of the AIDS progression.: Arch Immunol Ther Exp (Warsz). 1994;42(5-6):439-45. Unique Identifier : AIDSLINE MED/96171330; Piasecki E; Ledwon TK; Inglot AD; Knysz B; Simon K; Inglot M; Gladysz A; Laboratory of Virology, Polish Academy of Sciences, Wroclaw.; The blood samples taken from 31 HIV+ and AIDS patients were used to study interferon (IFN) and tumor necrosis factor (TNF) responses. The IFN and TNF levels in plasma were determined. In the whole blood assay (whole blood diluted 1:10 with culture medium) Newcastle disease virus (NDV) and phytohemagglutinin (PHA) were
Evidence for vaginal transmission of HIV [letter]: Arch Sex Behav. 1995 Dec;24(6):655-61. Unique Identifier : AIDSLINE MED/96152984; Carey MP; Kalichman SC
Host dependent variation of hepatitis C virus: phylogenetic analyses.: Arch Virol. 1995;140(12):2123-33. Unique Identifier : AIDSLINE MED/96140609; Maekawa S; Enomoto N; Kurosaki M; Marumo F; Sato C; Second Department of Internal Medicine, Tokyo Medical and Dental; University, Japan.; Hepatitis C virus quasispecies in six patients from three families were separated by single strand conformation polymorphism analysis and by determination of nucleotide sequences of envelope regions containing the E1 gene segment and hypervariable region-1 of each quasispecies. Four of the six patients had multiple qu
Both SU and TM env proteins are responsible for monkey cell tropism of simian immunodeficiency virus SIV mac.: Arch Virol. 1995;140(12):2255-60. Unique Identifier : AIDSLINE MED/96140618; Sakuragi S; Sakuragi J; Adachi A; Institute for Virus Research, Kyoto University, Japan.; While simian immunodeficiency virus (SIV) derived from an infectious molecular clone pMA239 is tropic and pathogenic for monkeys, the virus derived from another infectious clone pMA142 does not replicate in monkey cells. To determine genetic sequences responsible for this tropism, a series of recombinant clones were c
Aggressive conjunctival squamous cell carcinoma in three young Africans.: Arch Ophthalmol. 1996 Feb;114(2):215-8. Unique Identifier : AIDSLINE MED/96164709; Lewallen S; Shroyer KR; Keyser RB; Liomba G; Department of Ophthalmology, Queen Elizabeth Central Hospital,; Blantyre, Malawi.; Polymerase chain reaction was used to test for the presence of human papillomavirus in conjunctival squamous cell carcinomas from three young Africans with aggressive disease. Two of these patients had the acquired immunodeficiency syndrome. Test results for human papillomavirus were positive in all three cases.
Fluoxetine treatment of depressed patients with HIV infection.: Aust N Z J Psychiatry. 1995 Sep;29(3):433-6. Unique Identifier : AIDSLINE MED/96126499; Judd FK; Mijch AM; Cockram A; Fairfield Infectious Diseases Hospital, Victoria.; OBJECTIVE: The aim of this paper is to describe the outcome of fluoxetine treatment of depressed patients with HIV infection. METHOD: An open study was made of 20 patients with varying stages of HIV infection treated for depression with fluoxetine. RESULTS: 15 of 20 patients improved with fluoxetine treatment; the dru
Inhibition of NF-kappa B activation in human T-cell lines by anetholdithiolthione.: Biochem Biophys Res Commun. 1996 Jan 5;218(1):148-53. Unique Identifier : AIDSLINE MED/96136291; Sen CK; Traber KE; Packer L; Department of Molecular & Cell Biology, University of; California-Berkeley 94720-3200, USA.; Nuclear factor (NF)-kappa B is a redox sensitive cytosolic transcription factor. Redox regulation of NF-kappa B has been implicated in the activation of the human immuno-deficiency virus (HIV). Therefore, inhibition of NF-kappa B activation may be an effective strategy for acquired immunodeficiency syndrome therapy. A
Expression of HIV-1 envelope glycoprotein alters cellular calmodulin.: Biochem Biophys Res Commun. 1996 Jan 5;218(1):192-7. Unique Identifier : AIDSLINE MED/96136299; Radding W; Pan ZQ; Hunter E; Johnston P; Williams JP; McDonald JM; Department of Pathology, University of Alabama at Birmingham; 35294-0007, USA.; Removal of parts of a known calmodulin binding site at the C-terminus of HIV-1 envelope glycoprotein, gp160, can result in diminished infectivity. We investigated whether expression of full length gp160 would result in changes in intracellular calmodulin compared to expression of gp160 truncated to remove both known c
The Vpr protein of human immunodeficiency virus type 1 binds to nucleocapsid protein p7 in vitro.: Biochem Biophys Res Commun. 1996 Jan 5;218(1):352-5. Unique Identifier : AIDSLINE MED/96136326; Li MS; Garcia-Asua G; Bhattacharyya U; Mascagni P; Austen BM; Roberts MM; Department of Medical Microbiology, St. George's Hospital Medical; School, University of London, U.K.; The Vpr protein of human immunodeficiency virus type 1 (HIV-1) is incorporated into the virion by the Gag polyprotein precursor Pr55gag. The importance of the p6gag sequence at the C-terminal end of Pr55gag has a crucial role in Vpr incorporation. To identify the Gag sequences directly involved in Vpr binding, we comp
[Identification of immunoreactive epitopes in proteins coded by gag, env, and pol genes of the type I human T-lymphotropic virus (HTLV-I) using synthetic peptides]: Bioorg Khim. 1995 Oct;21(10):752-60. Unique Identifier : AIDSLINE MED/96096919; Iaroslavtseva NG; Ivanov VS; Grebennikova ZhO; Kornilaeva GV; Pashkova TA; Chikin LD; Ostrovskii AG; Andreev SM; Khaitov RM; Karamov EV; Reactivity of 26 synthetic peptides that comprise 12 to 26 amino acid residues corresponding to segments of the gag p19, env gp46, and pol proteins of human T-lymphotropic virus type I toward 31 positive sera was studied using enzyme-linked immunosorbent assay. Specific reactivity with high titers of antibodies (prese
[Substrate properties of dioxolane analogs of 3'-deoxythymidine-5'-triphosphate in DNA synthesis reactions, catalyzed by various DNA polymerases]: Bioorg Khim. 1995 Oct;21(10):781-9. Unique Identifier : AIDSLINE MED/96096923; Efimtseva EV; Mikhailov SN; Viktorova LS; Rozovskaia TA; Bibilashvili RSh; The substrate properties of 3 -deoxythymidine 5 -triphosphate analogs prepared on the basis of 2,4-disubstituted 1,3-dioxolanes were investigated in reactions of the DNA synthesis catalyzed by various DNA polymerases. The 4 -triphosphates of (+/-)-cis-4-hydroxymethyl-2-(1-thyminylmethyl)-1,3-dioxolane and the correspo
Perinatal AIDS in Southeast Asia [editorial]: Pediatr AIDS HIV Infect. 1995 Oct;6(5):257-61. Unique Identifier : AIDSLINE AIDS/96156173; MacDonald MG
Pneumocystis carinii pneumonia: a pediatric perspective.: Pediatr AIDS HIV Infect. 1995 Oct;6(5):262-70. Unique Identifier : AIDSLINE AIDS/96156174; Hunter JM; Cooper DM; Colin AA; Boston Children's Hospital, Massachusetts, USA.
Is sexual abuse in childhood or adolescence a predisposing factor for HIV infection during adolescence?: Pediatr AIDS HIV Infect. 1995 Oct;6(5):271-5. Unique Identifier : AIDSLINE AIDS/96156175; Lyon ME; Richmond D; D'Angelo LJ; Department of Adolescent and Young Adult Medicine, Children's; National Medical Center, Washington, D.C., USA.; This exploratory study was conducted to determine whether sexual abuse might be a risk factor or marker for other risk factors for Human Immunodeficiency Virus (HIV) infection. Twenty-five HIV-positive adolescents were assessed for a variety of possible risk factors for HIV infection, including prior history of sexual
Resting energy expenditure and body composition in pediatric HIV infection.: Pediatr AIDS HIV Infect. 1995 Oct;6(5):276-80. Unique Identifier : AIDSLINE AIDS/96156176; Alfaro MP; Siegel RM; Baker RC; Heubi JE; Department of Pediatrics, Children's Hospital Research; Foundation, Cincinnati, Ohio, USA.; One of the most striking features of HIV disease is the wasting syndrome or failure to thrive. Eighty percent of all perinatally HIV-infected children fail to grow normally. OBJECTIVE. Because severe malnutrition increases the morbidity of HIV infection and may shorten the already limited life expectancy of this popul
Growth hormone in HIV/AIDS: current uses and future prospects.: Pediatr AIDS HIV Infect. 1995 Oct;6(5):281-91. Unique Identifier : AIDSLINE AIDS/96156177; Laurence J; Laboratory for AIDS Virus Research, Cornell University Medical; College, New York, NY 10021, USA.; Recombinant human growth hormone (rhGH) and its primary induced product, insulin-like growth factor-I (IGF-I), have beneficial effects on a myriad of syndromes associated with catabolic metabolism in children and in adults. Their ability to promote nitrogen retention and protein synthesis and to enhance lipolysis has
Pediatric HIV infection and chronic myelogenous leukemia.: Pediatr AIDS HIV Infect. 1995 Oct;6(5):292-4. Unique Identifier : AIDSLINE AIDS/96156178; Verneris MR; Tuel L; Seibel NL; Department of Pediatrics, Children's National Medical Center,; George Washington University School of Medicine, Washington,; D.C., USA.; Malignancy occurs in 2-4% of children infected with human immunodeficiency virus (HIV). The most commonly reported type is non-Hodgkin s lymphoma . We describe the first reported case of chronic myelogenous leukemia (CML) in a child infected with HIV. The initial diagnosis was consi
The unrealized benefits of antiretroviral therapy.: Pediatr AIDS HIV Infect. 1995 Oct;6(5):295-300. Unique Identifier : AIDSLINE AIDS/96156179; Cohn JA; Department of Medicine, University of Maryland School of; Medicine, USA.
The prevention of maternal-fetal HIV-1 infection through passive antibody products (HIVIG) and active immunization (AIDS vaccines).: Pediatr AIDS HIV Infect. 1995 Oct;6(5):300-2. Unique Identifier : AIDSLINE AIDS/96156180; Lambert JS; Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
Semba RD, et al., Maternal vitamin A deficiency and mother-to-child transmission of HIV-1. Lancet 1994;343:1593-7.: Pediatr AIDS HIV Infect. 1995 Oct;6(5):303-4. Unique Identifier : AIDSLINE AIDS/96156181; Ramasethu J; Division of Neonatology Children's National Medical Center,; Washington, D.C., USA.
Mofenson, L.M., et al., for the Women and Infants Transmission Study Group, Mycobacterium tuberculosis infection in pregnant and non-pregnant women infected with HIV in the Women and Infants Transmission Study. (Arch Intern Med. 1995; 155:1066-72).: Pediatr AIDS HIV Infect. 1995 Oct;6(5):304-5. Unique Identifier : AIDSLINE AIDS/96156182; Revenis ME; Division of Neonatology, Children's National Medical Center,; Washington, DC, USA.
Nicoll A, et al., Infant feeding policy and practice in the presence of HIV-1 infection. AIDS 1995;9:107-19.: Pediatr AIDS HIV Infect. 1995 Oct;6(5):305-10. Unique Identifier : AIDSLINE AIDS/96156183; Ruff AJ; Department of International Health, Johns Hopkins School of; Hygiene and Public Health Baltimore, Maryland, USA.
Cytokines and transplantation: Th1/Th2 regulation of the immune response to solid organ transplants in the adult.: Curr Opin Immunol. 1995 Oct;7(5):632-8. Unique Identifier : AIDSLINE MED/96142863; Dallman MJ; Department of Biology, Imperial College of Science Technology and; Medicine, London, UK.; It has been very tempting to accept the suggestion that the route to rejection or tolerance of organ transplants is determined by T-helper type 1 and type 2 cells, respectively. Much of the data used to support this idea, however, is indirect and therefore cannot be used to imply a causal role for either population as
A direct association between HIV and AIDS in blood transfusion donors and recipients.: AIDS Res Hum Retroviruses. 1995 Oct;11(10):1147-8. Unique Identifier : AIDSLINE MED/96157200; Sullivan JS; Learmont J; Lumley T; Geczy AF; Cook L; Dyer WB; New South Wales Red Cross Blood Transfusion Service, Sydney,; Australia.
Hydroxyurea and AIDS: an old drug finds a new application?: AIDS Res Hum Retroviruses. 1995 Oct;11(10):1149-51. Unique Identifier : AIDSLINE MED/96157201; Lori F; Gallo RC; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892, USA.
Fine specificity of antibody recognition may predict amino acid substitution in the third variable region of gp120 during HIV type 1 infection.: AIDS Res Hum Retroviruses. 1995 Oct;11(10):1153-62. Unique Identifier : AIDSLINE MED/96157202; Langedijk JP; Zwart G; Goudsmit J; Meloen RH; Institute for Animal Science and Health (ID-DLO), Lelystad, The; Netherlands.; To investigate how human immunodeficiency virus type 1 (HIV-1) escapes from antibodies directed against the neutralization domain in the third variable region (V3) of gp120, we examined precisely which amino acid contributed to antibody binding. From six HIV-1-infected individuals, sequential sera were tested for anti
Random copolymers containing specific ratios of negatively charged and aromatic amino acids bind V3 disulfide loop and neutralize diverse HIV type 1 isolates.: AIDS Res Hum Retroviruses. 1995 Oct;11(10):1163-8. Unique Identifier : AIDSLINE MED/96157203; Javaherian K; McDanal C; Repligen Corporation, Cambridge, Massachusetts 02139, USA.; Random copolymers of polyamino acids containing negatively charged and aromatic residues at specific ratios appear to bind HIV type 1 V3 loop and neutralize diverse laboratory isolates. At least the putative heparin binding domain and isoleucine residues in the amino half of V3 are involved in the interactions with th
Maintenance of syncytium-inducing phenotype of HIV type 1 is associated with positively charged residues in the HIV type 1 gp120 V2 domain without fixed positions, elongation, or relocated N-linked glycosylation sites.: AIDS Res Hum Retroviruses. 1995 Oct;11(10):1169-75. Unique Identifier : AIDSLINE MED/96157204; Cornelissen M; Hogervorst E; Zorgdrager F; Hartman S; Goudsmit J; Human Retrovirus Laboratory, Academic Medical Centre, Amsterdam,; The Netherlands.; The prevalence of HIV-1 sequences of the envelope domains V1V2 and V3 was analyzed by RT-PCR amplification. Two distinct biological phenotypes of HIV-1 have been described: the nonsyncytium-inducing (NSI) phenotype, best characterized by the inability to infect MT-2 cells, and the syncytium-inducing phenotype (SI), wi
Antigenic analysis of HIV type 1 external envelope (Env) glycoprotein C2 region: implication for the structure of Env.: AIDS Res Hum Retroviruses. 1995 Oct;11(10):1177-86. Unique Identifier : AIDSLINE MED/96157205; Lemasson I; Housset V; Calas B; Devaux C; Laboratoire d'Immunologie des Infections Retrovirales, CNRS; UPR9008 et INSERM U249, Montpellier, France.; To determine whether the amino acid sequence extending from residue 273 to residue 288 in the second conserved region C2 of the HIV-1 envelope glycoprotein represents a target for antibodies on monomeric and oligomerized HIV-1 gp120env, we characterized several antisera and monoclonal antibodies (MAb) raised against C
Induction of HIV type 1 neutralizing and env-CD4 blocking antibodies by immunization with genetically engineered HIV type 1-like particles containing unprocessed gp160 glycoproteins.: AIDS Res Hum Retroviruses. 1995 Oct;11(10):1187-95. Unique Identifier : AIDSLINE MED/96157206; Rovinski B; Rodrigues L; Cao SX; Yao FL; McGuinness U; Sia C; Cates G; Zolla-Pazner S; Karwowska S; Matthews TJ; et al; Department of Molecular Genetics, Connaught Centre for; Biotechnology Research, Willowdale, Ontario, Canada.; Genetically engineered, noninfectious HIV-1-like particles containing processed envelope glycoproteins represent potential candidate immunogens for a vaccine against HIV-1. However, since the gp120 glycoprotein is known to be rapidly lost from the surface of infected cells and purified virions as a result of its low-a
The genetic diversification of the HIV type 1 gag p17 gene in patients infected from a common source.: AIDS Res Hum Retroviruses. 1995 Oct;11(10):1197-201. Unique Identifier : AIDSLINE GENBANK/U32149; Kasper P; Simmonds P; Schneweis KE; Kaiser R; Matz B; Oldenburg J; Brackmann HH; Holmes EC; Institut fur Medizinische Mikrobiologie und Immunologie,; Universitat Bonn, Germany.; An evolutionary analysis was undertaken of HIV-1 gag p17 sequences taken from a small cohort of hemophilia B patients infected from a common batch of clotting factor concentrate. The sequence population found at seroconversion was highly homogeneous, suggesting that the infecting batch also contained little sequence v
Plasma viremia titration and RNA quantitation in ICD-p24 negative HIV type-1-infected patients.: AIDS Res Hum Retroviruses. 1995 Oct;11(10):1203-7. Unique Identifier : AIDSLINE MED/96157208; Ercoli L; Sarmati L; el-Sawaf G; Cochi S; Lanti T; Iudicone P; Guglielmetti M; Giannini G; Galluzzo C; Tomino C; et al; Department of Public Health and Cellular Biology, University Tor; Vergata, Rome, Italy.; Quantitative culture of human immunodeficiency virus (HIV) was performed on 202 plasma samples obtained from asymptomatic and early symptomatic HIV-1 infected patients (mean CD4+ count: 186/mm3) before antiretroviral therapy was started. HIV could be isolated from 84% of the plasma samples (titers ranging from 10(0) t
Immunological characteristics of HIV-infected children: relationship to age, CD4 counts, disease progression, and survival.: AIDS Res Hum Retroviruses. 1995 Oct;11(10):1209-19. Unique Identifier : AIDSLINE MED/96157209; Chirmule N; Lesser M; Gupta A; Ravipati M; Kohn N; Pahwa S; Department of Pediatrics, North Shore University Hospital-Cornell; University Medical College, Manhasset, New York 11030, USA.; We have evaluated immunologic markers of disease progression in 79 children perinatally infected with HIV. Laboratory testing included T lymphocyte subsets and lymphoproliferative responses (LPR) to mitogens (PHA, Con A, and PWM), antigens (Candida, Tetanus), and alloantigens (MLC). Patients were graded into grades I,
The appearance of drug resistance-associated point mutations in HIV type 1 plasma RNA precedes their appearance in proviral DNA.: AIDS Res Hum Retroviruses. 1995 Oct;11(10):1221-5. Unique Identifier : AIDSLINE MED/96157210; Kaye S; Comber E; Tenant-Flowers M; Loveday C; Department of Virology, University College London Medical School,; U.K.; Point mutations in the reverse transcriptase (RT) gene of human immunodeficiency virus type-1 (HIV-1) have been associated with reduced sensitivity of the virus to inhibition by the antiretroviral drug zidovudine (ZDV). During therapy we have previously observed the accumulation of these mutations, at codons 41, 67, 7
Intracellular activation and cytotoxicity of three different combinations of 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine.: AIDS Res Hum Retroviruses. 1995 Oct;11(10):1227-33. Unique Identifier : AIDSLINE MED/96157211; Palmer S; Cox S; Virology Department, Swedish Institute for Infectious Disease; Control, Karolinska Institute, Stockholm, Sweden.; We measured the intracellular activation and cytotoxicity of 3 -azido-3 -deoxythymidine (zidovudine, ZDV) and 2 ,3 -dideoxyinosine (ddI) when combined at three different clinically relevant combinations of 1:1, 1:10, and 10:1 (ZDV:ddI). The activation of ddI to ddA-TP was increased in all three combinations with ZDV,
Investigation of proviral load in individuals infected with human T-lymphotropic virus type II.: AIDS Res Hum Retroviruses. 1995 Oct;11(10):1235-9. Unique Identifier : AIDSLINE MED/96157212; Woods TC; Graber JM; Hershow RC; Khabbaz RF; Kaplan JE; Heneine W; Retrovirus Diseases Branch, Centers for Disease Control and; Prevention, Atlanta, Georgia 30333, USA.; Human T-lymphotrophic virus type II (HTLV-II) has not yet been associated with any disease. Little is known about the proviral loads of HTLV-II in vivo and its relationship, if any, to lack of pathogenicity. We determined the HTLV-II proviral copy number in peripheral blood lymphocyte (PBL) samples from 49 HTLV-II-inf
Human herpesvirus 6 variant A, but not variant B, infects EBV-positive B lymphoid cells, activating the latent EBV genome through a BZLF-1-dependent mechanism.: AIDS Res Hum Retroviruses. 1995 Oct;11(10):1241-5. Unique Identifier : AIDSLINE MED/96157213; Cuomo L; Angeloni A; Zompetta C; Cirone M; Calogero A; Frati L; Ragona G; Faggioni A; Dipartimento di Medicina Sperimentale, Universita La Sapienza,; Rome, Italy.; Human herpesvirus 6, a predominantly T lymphotropic virus, has been recently shown to infect some EBV-positive B cell lines, and to induce in them the activation of the EBV lytic cycle. Here we have confirmed and extended such observations, showing that (1) this phenomenon is restricted to the variant A of HHV-6: in f
Regional distribution of lesions in the central nervous system of cats infected with feline immunodeficiency virus.: AIDS Res Hum Retroviruses. 1995 Oct;11(10):1247-53. Unique Identifier : AIDSLINE MED/96157214; Abramo F; Bo S; Canese MG; Poli A; Department of Animal Pathology, University of Pisa, Italy.; Neuropathological examination of the central nervous system of 13 naturally and 13 experimentally feline immunodeficiency virus (FIV)-infected cats revealed diffuse gliosis of gray and white matter and vacuolar myelinopathy in a large proportion of infected animals, sometimes associated with lymphocytic meningitis. Mu
Molecular characterization of human T-lymphotropic virus, type 1 (HTLV-1) found in Kuwait: close similarity with HTLV-1 isolates originating from Mashhad, Iran.: AIDS Res Hum Retroviruses. 1995 Oct;11(10):1255-9. Unique Identifier : AIDSLINE GENBANK/L42225; Voevodin A; al-Mufti S; Farah S; Khan R; Miura T; Department of Microbiology, Faculty of Medicine, Kuwait; University.; Human T-lymphotropic virus, type 1 (HTLV-1) infection was detected in two unrelated Kuwaiti patients with tropical spastic paraparesis (HAM/TSP) and in the asymptomatic mother of one of them. The family roots of these patients were traced to the Najaf region of
Sequence analysis of simian T cell lymphoma/leukemia virus type 1 from naturally infected monkeys from central and west Africa reveals evolutionary conservation of immunogenic and neutralizing domains of gp46.: AIDS Res Hum Retroviruses. 1995 Oct;11(10):1261-3. Unique Identifier : AIDSLINE GENBANK/U33946; Saksena N; Ge YC; Herve V; Diop O; Miranda-Saksena M; Mathiot C; Digoutte JP; Department of Virology, ICPMR, Westmead Hospital, Sydney,; Australia.
Analysis of partial gag and env gene sequences of HIV type 1 strains from southern Africa.: AIDS Res Hum Retroviruses. 1995 Oct;11(10):1265-7. Unique Identifier : AIDSLINE GENBANK/X52154; Becker ML; De Jager G; Becker WB; Department of Virology, Tygerberg Hospital, South Africa.
Identification of env subtypes in fourteen HIV type 1 isolates from south Africa.: AIDS Res Hum Retroviruses. 1995 Oct;11(10):1269-71. Unique Identifier : AIDSLINE GENBANK/U33782; Engelbrecht S; Laten JD; Smith TL; van Rensburg EJ; Department of Medical Virology, University of Stellenbosch,; Tygerberg, South Africa.
Conference on Advances in AIDS Vaccine Development: 7th annual meeting of the National Cooperative Vaccine Development Groups for AIDS. November 6-10, 1994.: AIDS Res Hum Retroviruses. 1995 Oct;11(10):1273-319. Unique Identifier : AIDSLINE MED/96171771
Suppression of activation of the human immunodeficiency virus long terminal repeat by CD8+ T cells is not lentivirus specific.: AIDS Res Hum Retroviruses. 1995 Nov;11(11):1321-6. Unique Identifier : AIDSLINE MED/96159128; Copeland KF; McKay PJ; Rosenthal KL; Department of Pathology, McMaster University Health Sciences; Centre, Hamilton, Ontario, Canada.; CD8+ T lymphocytes of HIV-1-infected individuals can efficiently suppress HIV-1 replication in CD4+ T lymphocytes. To elucidate the molecular events underlying this suppression, we have used the HIV-1 LTR directing the chloramphenicol acetyltransferase gene (CAT) in transient transfection assays using human Jurkat T c
Expansion of CD11abright cells in CD8+CD45RA+ from HIV-infected patients: a new early marker for disease progression?: AIDS Res Hum Retroviruses. 1995 Nov;11(11):1327-33. Unique Identifier : AIDSLINE MED/96159129; Scala E; Ansotegui IJ; Bellioni B; Guerra EC; Aiuti F; Paganelli R; Department of Clinical Medicine, University of Rome, La Sapienza,; Italy.; CD8+CD45RA+ T lymphocytes present two distinct subpopulations expressing the CD11a molecule (LFA-1 alpha chain) with different intensity. CD11adim cells represent the unprimed population within the CD8+CD45RA+ subset, whereas CD11abright cells are activated and may be considered as memory lymphocytes. The aim of this
Helper and cytotoxic T cell responses of HIV type 1-infected individuals to synthetic peptides of HIV type 1 Rev.: AIDS Res Hum Retroviruses. 1995 Nov;11(11):1335-42. Unique Identifier : AIDSLINE MED/96159130; Blazevic V; Ranki A; Krohn KJ; Institute of Medical Technology, University of Tampere, Finland.; In cell-mediated immunity T cells recognize peptide fragments of the antigenic protein in association with major histocompatibility complex (MHC) proteins. Synthetic 9- to 16-mer peptides have been widely used to identify the region(s) of a protein that act as T cell epitope. Here, we report antigenic peptides identif
Analysis of trans-dominant mutants of the HIV type 1 Rev protein for their ability to inhibit Rev function, HIV type 1 replication, and their use as anti-HIV gene therapeutics.: AIDS Res Hum Retroviruses. 1995 Nov;11(11):1343-53. Unique Identifier : AIDSLINE MED/96159131; Ragheb JA; Bressler P; Daucher M; Chiang L; Chuah MK; Vandendriessche T; Morgan RA; National Heart, Lung, and Blood Institute, Bethesda, Maryland,; USA.; The HIV-1 rev gene product facilitates the transport of singly spliced and unspliced HIV-1 transcripts and is necessary for productive HIV-1 infection. On the basis of the previously described trans-dominant Rev mutant M10, four point mutants and one frameshift mutant of the Rev protein were constructed. The mutants w
Inhibition of HIV type 1 Tat-mediated trans-activation by oncostatin M in HLtat cells.: AIDS Res Hum Retroviruses. 1995 Nov;11(11):1355-8. Unique Identifier : AIDSLINE MED/96159132; Este JA; Witvrouw M; Tu J; Desmyter J; De Clercq E; Vandamme AM; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.; We have tested the effect of oncostatin M (OSM) on the Tat-mediated trans-activation in a HeLa cell line (HLtat) expressing Tat, using a transfection assay with the LacZ gene under the control of the HIV-1 LTR. Oncostatin M reduced the LacZ expression by 50% at a concentration of 9.5 ng/ml (IC50), which was far below
Anti-Tat MTT assay: a novel anti-HIV drug screening system using the viral regulatory network of replication.: AIDS Res Hum Retroviruses. 1995 Nov;11(11):1359-66. Unique Identifier : AIDSLINE MED/96159133; Kira T; Merin JP; Baba M; Shigeta S; Okamoto T; Department of Microbiology, Fukushima Medical College, Japan.; Since the recognition of its pivotal role in viral replication, Tat activity has become an interesting target for chemotherapeutic intervention of HIV infection. Here, we report a sensitive and simple colorimetric assay for the screening of Tat inhibitors. We have constructed a plasmid that contains the hygromycin B p
Function of exon 2 in optimal trans-activation by Tat of HIV type 2.: AIDS Res Hum Retroviruses. 1995 Nov;11(11):1367-72. Unique Identifier : AIDSLINE MED/96159134; Pagtakhan AS; Tong-Starksen SE; Department of Medicine, Veterans Administration Medical Center,; San Francisco, California, USA.; HIV-1 and HIV-2 are human retroviruses whose life cycles require viral regulatory proteins, one of which is the trans-activator, Tat. Tat of HIV-1 (Tat-1) displays modular function with independent activation function localized to the amino-terminal, cysteine-rich, and core regions and independent RNA-binding function
Structural modification of serum vitamin D3-binding protein and immunosuppression in AIDS patients.: AIDS Res Hum Retroviruses. 1995 Nov;11(11):1373-8. Unique Identifier : AIDSLINE MED/96159135; Yamamoto N; Naraparaju VR; Srinivasula SM; Laboratory of Cancer Immunology and Molecular Biology, Albert; Einstein Cancer Center, Philadelphia, Pennsylvania 19141, USA.; A serum glycoprotein, vitamin D3-binding protein (Gc protein), can be converted by beta-galactosidase of stimulated B lymphocytes and sialidase of T lymphocytes to a potent macrophage-activating factor (MAF), a protein with N-acetylgalactosamine as the remaining sugar moiety. Thus, Gc protein is a precursor for MAF. T
Differential role of V3-specific antibodies in neutralization assays involving primary and laboratory-adapted isolates of HIV type 1.: AIDS Res Hum Retroviruses. 1995 Nov;11(11):1379-91. Unique Identifier : AIDSLINE MED/96159136; Vancott TC; Polonis VR; Loomis LD; Michael NL; Nara PL; Birx DL; Division of Retrovirology, Walter Reed Army Institute of; Research, Rockville, Maryland 20850, USA.; To identify epitopes important in neutralizing primary HIV-1 isolates, we have selectively depleted HIV-1 sera of antibodies specific for the third hypervariable region (V3) of the HIV-1 envelope glycoprotein gp120, and then assessed the functional consequences of such depletion in neutralization assays. The nucleotid
Low anticoagulant heparin retains anti-HIV type 1 activity in vitro.: AIDS Res Hum Retroviruses. 1995 Nov;11(11):1393-6. Unique Identifier : AIDSLINE MED/96159137; Coombe DR; Harrop HA; Watton J; Mulloy B; Barrowcliffe TW; Rider CC; Institute for Child Health Research, Perth, Western Australia.; Heparin is a potent inhibitor of HIV-1 replication, in addition to being a well-established inhibitor of blood coagulation. The major anticoagulant activity of heparin results from binding to the plasma protein antithrombin (AT). The high-affinity binding site for AT is a specific pentasaccharide sequence that is of l
Highly attenuated SIVmac142 is immunogenic but does not protect against SIVmac251 challenge.: AIDS Res Hum Retroviruses. 1995 Nov;11(11):1397-406. Unique Identifier : AIDSLINE MED/96159138; Denesvre C; Le Grand R; Boissin-Cans F; Chakrabarti L; Hurtrel B; Vaslin B; Dormont D; Sonigo P; ICGM-CNRS UPR415, Institut Cochin de Genetique Moleculaire,; Paris, France.; We report here the use of the highly attenuated SIVmac142 clone, unable to establish permanent infection of rhesus macaques, in a vaccine trial. Four rhesus macaques were immunized over a long time period with HUT-78 cells infected with wild-type SIVmac142 or, in order to reinforce the safety use of the vaccine, a del
Identification of new genetic subtypes of human T cell leukemia virus type I in Gabon from encoding sequence of surface envelope glycoprotein.: AIDS Res Hum Retroviruses. 1995 Nov;11(11):1407-11. Unique Identifier : AIDSLINE MED/96159139; Moynet D; Cosnefroy JY; Bedjabaga I; Roelants G; Georges-Courbot MC; Guillemain B; INSERM, Unite 328, Structures et Fonctions des Retrovirus; Humains, Bordeaux, France.
A computer program designed to screen rapidly for HIV type 1 intersubtype recombinant sequences.: AIDS Res Hum Retroviruses. 1995 Nov;11(11):1413-6. Unique Identifier : AIDSLINE MED/96159140; Siepel AC; Halpern AL; Macken C; Korber BT; Los Alamos National Laboratory, New Mexico 87545, USA.
Topiary pruning of the HIV and SIV phylogenetic tree.: AIDS Res Hum Retroviruses. 1995 Nov;11(11):1417-9. Unique Identifier : AIDSLINE MED/96159141; Wills C; Department of Biology, University of California, San Diego, La; Jolla 92093, USA.
HIV-1 subtype A in Canada.: AIDS Res Hum Retroviruses. 1995 Nov;11(11):1421-2. Unique Identifier : AIDSLINE MED/96159142; Montpetit M; Bureau of HIV/AIDS Laboratories and Research, Ottawa, Ontario,; Canada.
Identification of breakpoints in intergenotypic recombinants of HIV type 1 by bootscanning.: AIDS Res Hum Retroviruses. 1995 Nov;11(11):1423-5. Unique Identifier : AIDSLINE MED/96159143; Salminen MO; Carr JK; Burke DS; McCutchan FE; Henry M. Jackson Foundation for the Advancement of Military; Medicine, Rockville, Maryland 20850, USA.
Karyotyping of fluconazole-resistant yeasts with phenotype reported as Candida krusei or Candida inconspicua.: Int J Syst Bacteriol. 1996 Jan;46(1):35-40. Unique Identifier : AIDSLINE MED/96138963; Essayag SM; Baily GG; Denning DW; Burnie JP; Department of Medical Microbiology, Manchester Royal Infirmary,; University of Manchester, United Kingdom.; The yeasts Candida krusei and Candida inconspicua have similar phenotypes, which may make discrimination of these organisms difficult. In this study we determined the karyotypes of 51 isolates of these two yeast species by contour-clamped homogeneous electric field electrophoresis. We found that the 43 isolates that h
Verruga peruana: an infectious endemic angiomatosis.: Crit Rev Oncog. 1995;6(1):47-56. Unique Identifier : AIDSLINE MED/96157416; Caceres-Rios H; Rodriguez-Tafur J; Bravo-Puccio F; Maguina-Vargas C; Diaz CS; Ramos DC; Patarca R; Servicio de Dermatologia, Instituto Nacional del Nino, Lima,; Peru.; Microbial-related dysplastic and neoplastic angiomatous proliferative processes are seen with increased frequency, particularly in the acquired immunodeficiency syndrome (AIDS). The microbial-encoded or -induced mediators of angiopathogenesis in AIDS-associated Kaposi s sarcoma and
Transduction of rIL-2 expanded CD4+ and CD8+ ovarian TIL-derived T cell lines with the G1Na (neor) replication-deficient retroviral vector.: Hum Gene Ther. 1995 Nov;6(11):1379-89. Unique Identifier : AIDSLINE MED/96139252; Nash MA; Platsoucas CD; Wong BY; Wong PM; Cottler-Fox M; Otto E; Freedman RS; Department of Gynecologic Oncology, University of Texas M.D.; Anderson Cancer Center, Houston 77030, USA.; We have expanded ovarian tumor-infiltrating lymphocytes (TIL) in low concentrations of recombinant interleukin-2 (rIL-2) to conduct intraperitoneal adoptive immunotherapy trials in patients with ovarian cancer. We have previously demonstrated that certain T cell lines and clones derived from ovarian TIL exhibit in vit
HIV-regulated diphtheria toxin A chain gene confers long-term protection against HIV type 1 infection in the human promonocytic cell line U937.: Hum Gene Ther. 1995 Nov;6(11):1437-45. Unique Identifier : AIDSLINE MED/96139257; Dinges MM; Cook DR; King J; Curiel TJ; Zhang XQ; Harrison GS; Department of Pediatrics, University of Minnesota Hospital and; Clinic, Minneapolis 55455, USA.; Gene therapy approaches have recently been investigated for the treatment of acquired immunodeficiency syndrome (AIDS), both in preclinical and clinical studies, because more traditional antiviral agents have proven to be of limited effectiveness. We have previously shown that long-term protection against both laborat
A simple quantitative culture of Malassezia spp. in HIV-positive persons.: Dermatology. 1995;191(4):348-9. Unique Identifier : AIDSLINE MED/96159488; Pechere M; Remondat C; Bertrand C; Didierjean L; Saurat JH; Department of Dermatology, Geneva University Hospital,; Switzerland.; BACKGROUND: Etiological role of Malassezia spp. remains controversial in certain skin diseases. OBJECTIVE: To adapt a tape method for quantitative culture of Malassezia spp. METHOD: Samples for culture were taken from clinically normal forehead skin of HIV-positive and negative persons by stripping with a tape that
Pseudomonas aeruginosa as a cause of infectious diarrhea successfully treated with oral ciprofloxacin.: Ann Pharmacother. 1995 Nov;29(11):1122-3. Unique Identifier : AIDSLINE MED/96156285; Porco FV; Visconte EB; Department of Internal Medicine, Lutheran Medical Center,; Brooklyn, NY 11220, USA.; OBJECTIVE: To describe an immunocompromised patient (without AIDS) with nosocomial infectious diarrhea caused by Pseudomonas aeruginosa. Oral ciprofloxacin therapy proved to be effective. CASE SUMMARY: An 80-year-old woman with type II diabetes mellitus and hypertension developed progressive renal insufficiency, was h
Rifabutin-associated uveitis.: Ann Pharmacother. 1995 Nov;29(11):1149-55. Unique Identifier : AIDSLINE MED/96156289; Tseng AL; Walmsley SL; Wellesley Health Center, University of Toronto, Ontario, Canada.; OBJECTIVE: To review rifabutin-associated uveitis and discuss the mechanism and potential role of drug interactions with clarithromycin and fluconazole in contributing to this adverse event. DATA SOURCES: A MEDLINE search (1991 through September 1994) of English-language literature using the main MeSH headings rifabut
Clinical utility of a new contrast option from magnetization transfer contrast.: J Magn Reson Imaging. 1995 Sep-Oct;5(5):545-50. Unique Identifier : AIDSLINE MED/96107641; Gillams AR; Silver MS; Carter AP; Boston University Medical School, MA 02118, USA.; Two magnetization transfer (MT) contrast effects, a T2-like effect and the improved contrast observed when gadolinium is used with MT, are combined in a single sequence. Forty patients (22 males:18 females; mean age, 45 years (23-87)) with suspected intracranial pathology underwent MRI on a 1.5 Tesla system. Of 46 les
Message from the director of the RCMI program.: Cell Mol Biol (Noisy-le-grand). 1995;41 Suppl 1:Siii-Siv. Unique Identifier : AIDSLINE MED/96171627; McNairy SA Jr; Research Centers in Minority Institutions Program, National; Institutes of Health, Bethesda, Maryland, USA.
Special issue on AIDS.: Cell Mol Biol (Noisy-le-grand). 1995;41 Suppl 1:S1-161. Unique Identifier : AIDSLINE MED/96171626
Synthesis and anti-HIV activity of steroidal prodrugs of 3'-azido-3'-deoxythymidine (AZT).: Cell Mol Biol (Noisy-le-grand). 1995;41 Suppl 1:S1-7. Unique Identifier : AIDSLINE MED/96171628; Balagopala MI; Ollapally AP; Lee HJ; Department of Chemistry, Florida A. & M. University, Tallahassee; 32307, USA.; A total of seven steroidal prodrugs of AZT were synthesized and tested in vitro for their anti-HIV activity. Three of them were steroidal carboxylic esters prepared from steroidal 17 beta-carboxylic acids and AZT. The remaining four were alkyl steroid
Zidovudine as an immunomodulatory agent.: Cell Mol Biol (Noisy-le-grand). 1995;41 Suppl 1:S103-12. Unique Identifier : AIDSLINE MED/96171640; Urso P; Majekodunmi MJ; Cobb JR; Lemon T; Etemadi AA; Jones TM; Wirsiy YG; Department of Microbiology and Immunology, Morehouse School of; Medicine, Atlanta, GA 30310, USA.; In view of the increase of HIV infection in women, and of transplacental infectivity, 3 -azido-3 -deoxythymidine (zidovudine) is being explored to control infection in offspring. Zidovudine toxicity in humans and experimental animals is well documented. However, information on immunotoxicity in pregnant females and th
Uptake and distribution of 2',3'-dideoxyinosine and its derivatives in a human monocytoid cell line.: Cell Mol Biol (Noisy-le-grand). 1995;41 Suppl 1:S113-9. Unique Identifier : AIDSLINE MED/96171641; Vazquez-Padua MA; Mayol N; Lopez M; Department of Anatomy and Cell Biology, Universidad Central del; Caribe, School of Medicine, Bayamon, Puerto Rico 00960-6032.; The dideoxynucleoside analogue 2 ,3 -dideoxyinosine (ddI) has been used in the clinic as an alternative drug to zidovudine ( AZT ) in the treatment of patients with the acquired immunodeficiency syndrome (AIDS). However, it shows significant and variabl
Anti-CD4 cytotoxic T lymphocyte (CTL) activity in HIV+ patients: flow cytometric analysis.: Cell Mol Biol (Noisy-le-grand). 1995;41 Suppl 1:S133-44. Unique Identifier : AIDSLINE MED/96171643; Yamamura Y; Rodriguez N; Schwartz A; Eylar E; Yano N; Ponce School of Medicine, AIDS Research Program, Puerto Rico; 00732.; A new cell proliferation analysis by flow cytometry was applied to the mitogen induced cultures of peripheral blood mononuclear cells (PBMC) from either normal, healthy donors or those individuals who are infected by human immunodeficiency virus, type 1 (HIV-1). While phytohemagglutinin (PHA) stimulation of normal PBM
Molecular phylogeny and dissemination of human T-cell lymphotropic virus type I viewed within the context of primate evolution and human migration.: Cell Mol Biol (Noisy-le-grand). 1995;41 Suppl 1:S145-61. Unique Identifier : AIDSLINE GENBANK/M92818; Yanagihara R; Saitou N; Nerurkar VR; Song KJ; Bastian I; Franchini G; Gajdusek DC; Laboratory of Central Nervous System Studies, National Institute; of Neurological Disorders and Stroke, National Institutes of; Health, Bethesda, Maryland 20892, USA.; A renewed interest in the emergence and evolution of the primate T-cell lymphotropic viruses has followed the discovery of genetically distinct variants of human T-cell lymphotropic virus type I (HTLV-I) in Melanesia and Australia . Phylogenetic trees based on selected regions of
Calmodulin inhibitors and calcium channel blockers influence dideoxycytidine renal excretion.: Cell Mol Biol (Noisy-le-grand). 1995;41 Suppl 1:S15-8. Unique Identifier : AIDSLINE MED/96171630; Enigbokan MA; West D; Preston J; Thompson JO; College of Pharmacy and Health Sciences, Texas Southern; University, Houston 77004, USA.; Renal handling of 2 ,3 -dideoxycytidine ( ddC ), a new anti-HIV dideoxynucleoside which undergoes renal and non-renal clearance, was determined in CF-1 male mice. Since calmodulin inhibitors (CIs) and calcium channel blockers (CCBs) have been shown to i
Prevalence of enteric parasitic infection among HIV-infected attendees of an inner city AIDS clinic.: Cell Mol Biol (Noisy-le-grand). 1995;41 Suppl 1:S19-23. Unique Identifier : AIDSLINE MED/96171631; Esfandiari A; Jordan WC; Brown CP; Dept. of Otolaryngology, Drew University of Medicine and Science,; Los Angeles, CA 90059, USA.; One hundred individuals confirmed to be infected with the human immunodeficiency virus (HIV), volunteered to participate in a pilot study comparing clinical status and enteric parasite burden with race, age, CD4 levels, risk factors and sexual practice. The prevalence of enteric parasites was 55 (55%) for Giardia lamb
Suppressed proliferative response and interleukin-2 production in hispanic HIV+ and AIDS T-cell subsets.: Cell Mol Biol (Noisy-le-grand). 1995;41 Suppl 1:S25-33. Unique Identifier : AIDSLINE MED/96171632; Eylar EH; Baez I; Vazquez A; Colon-Martinez SL; Yamamura Y; Department of Biochemistry, Ponce School of Medicine 00732,; Puerto Rico.; We find that interleukin-2 ( IL-2 ) production is severely depressed (80-90%) in AIDS T-cells (CD4+ or CD8+) stimulated with anti-CD3 or Con A together with phorbol ester (PMA) or anti-CD28 coactivation. Likewise, the proliferative response of CD4+ T-cells was suppressed
N-acetylcysteine (NAC) enhances interleukin-2 but suppresses interleukin-4 secretion from normal and HIV+ CD4+ T-cells.: Cell Mol Biol (Noisy-le-grand). 1995;41 Suppl 1:S35-40. Unique Identifier : AIDSLINE MED/96171633; Eylar EH; Baez I; Vazquez A; Yamamura Y; Department of Biochemistry and Microbiology, Ponce School of; Medicine, Puerto Rico 00732.; We find that purified CD4+ T cells from 30 HIV+ individuals have a suppressed Interleukin-4 (IL-4) production compared to normal controls regardless of activator (anti-CD3 or Con A) or co-activator [phorbol ester (PMA or anti-CD28)], generally by 2-4 fold. In every case, the cells producing IL-4 respond more strongly
Properties of virus-like particles produced by SIV-chronically infected human cell clones.: Cell Mol Biol (Noisy-le-grand). 1995;41 Suppl 1:S41-52. Unique Identifier : AIDSLINE MED/96171634; Kraiselburd EN; Torres JV; Dept. of Microbiology and Medical Zoology, UPR School of; Medicine, San Juan 00936-5067, Puerto Rico.; SIVsm chronically infected cultures were obtained after infection of CEMX174 cells with either SIVsmH3 or SIVsmE660. These phenotypically CD4 cells, formed syncytia but only when cocultivated with CD4+ cells. Single cell clones were derived from these cultures and examined for the production of virus-specific proteins
HIV/AIDS in Costa Rica: epidemiological and sociological features, 1993.: Cell Mol Biol (Noisy-le-grand). 1995;41 Suppl 1:S53-63. Unique Identifier : AIDSLINE MED/96171635; Mata L; Ramirez G; Quesada J; Section of Infection/Nutrition, University of Costa Rica,; Guadalupe.; Acquired immunodeficiency syndrome (AIDS) was first detected in Costa Rica in 1983. For four years most known cases were in hemophiliac men. Thereafter, AIDS in homosexual and bisexual men predominated. By December 31 of 1993, 563 persons had been diagnosed with the syndrome, 71
Changes in serum antioxidant concentrations during infection with caprine lentivirus.: Cell Mol Biol (Noisy-le-grand). 1995;41 Suppl 1:S65-72. Unique Identifier : AIDSLINE MED/96171636; Mdurvwa EG; Ogunbiyi PO; Reddy PG; Gakou HS; Sodeke SO; Carty AJ; Center for Biomedical Research/RCMI, Carver Research Foundation,; Tuskegee University, Alabama 36088, USA.; We are currently using caprine arthritis encephalitis virus (CAEV) infection in goats as a model to understand changes in some clinical parameters and host response to infection with human immunodeficiency virus (HIV). The objective of this study was to measure changes in serum antioxidant activities in various age gr
Distribution of linear antigenic epitopes on GP120 encoded in sibling clones of novel New York HIV-1 subtype B isolates.: Cell Mol Biol (Noisy-le-grand). 1995;41 Suppl 1:S83-91. Unique Identifier : AIDSLINE MED/96171638; Riley JP; Pestano GA; Harewood K; Alfred LJ; Guyden J; Boto WM; Department of Biology and Chemistry, City College of the City; University of New York, NY 10031, USA.; We have initiated studies to characterize the predominant subtypes of HIV-1 which account for infections in a defined cohort of intravenous (IV) drug addicts. A region of ENV encoding the C2 to the V5 regions was amplified from the leukocytes of two subjects currently enrolled in a methadone maintenance program at the
Synthesis, activity and toxicity of novel macrocyclic ligands against HIV-1 in Jurkat and CEM-SS cell lines.: Cell Mol Biol (Noisy-le-grand). 1995;41 Suppl 1:S9-14. Unique Identifier : AIDSLINE MED/96171629; Balogh-Nair V; Brathwaite CE; Chen CX; Vargas J Jr; Department of Chemistry, City College of New York, CUNY 10031,; USA.; We have developed versatile synthetic routes that afford metal-free macrocycles containing different functionalities in their framework. Novel oxaziridine and amide containing macrocycles were synthesized, and the metal complexes of the latter were also prepared. A series of theophilline and thymidine side-arm contain
Changes in viral expression and cytokine profile induced by a polyantigenic immunomodulator in HIV-infected peripheral blood mononuclear cells.: Cell Mol Biol (Noisy-le-grand). 1995;41 Suppl 1:S93-101. Unique Identifier : AIDSLINE MED/96171639; Rios Z; Rios EO; Garcia MI; De Leon C; Guzman LM; Rodriguez W; Romero D; Hunter R; Department of Microbiology and Immunology, Universidad Central; del Caribe, School of Medicine, Bayamon, Puerto Rico 00960-6032.; This is the first time, to our knowledge, that evidence is presented showing that a polyantigenic immunomodulator (PAI), acting as a biological response modifier, can either induce or suppress HIV expression depending on the viral load of infected PBMC. PAI consists of a mixture of inactivated bacteria with influenza
Frequent presence of latent Epstein-Barr virus infection in peripheral T cell lymphomas. A review.: Leuk Lymphoma. 1995 Sep;19(1-2):1-12. Unique Identifier : AIDSLINE MED/96116921; Anagnostopoulos I; Hummel M; Stein H; Institute of Pathology, Klinikum Benjamin Franklin, Free; University Berlin, Germany.; Two-hundred and four cases of peripheral T cell lymphoma (PTCL) occurring in Europeans without any sign of HIV-infection were investigated for their association with an Epstein-Barr virus (EBV) infection. Polymerase chain reaction (PCR) was applied for EBV-DNA detection, in situ hybridisation (ISH) for the cellular lo
In situ PCR: protocols and applications.: PCR Methods Appl. 1995 Feb;4(4):S151-67. Unique Identifier : AIDSLINE MED/96000051; Nuovo GJ; Department of Pathology, State University of New York at Stony; Brook 11794, USA.; Many groups have now published data based on the in situ detection of PCR-amplified DNA and cDNA. As with standard in situ hybridization or PCR, variables that can affect in situ PCR results include type of fixative and time of fixation, protease digestion, and the composition of the amplifying solution and oligoprobe
The one-tube quantitative HIV-1 RNA NASBA: precision, accuracy, and application.: PCR Methods Appl. 1995 Feb;4(4):S177-84. Unique Identifier : AIDSLINE MED/96000053; van Gemen B; v d Wiel P; van Beuningen R; Sillekens P; Jurriaans S; Dries C; Schoones R; Kievits T; Organon Teknika, Boxtel, The Netherlands.
[Infection caused by Mycobacterium tuberculosis with primary resistance to multiple drugs: a case report of a patient with AIDS]: Rev Assoc Med Bras. 1995 May-Jun;41(3):255-6. Unique Identifier : AIDSLINE MED/96098905; Grinbaum RS; Daher M; Medeiros EA; de Mendonca JS; Beu MF; Kusano E; Telles MA; Ueki SY; Servico de Molestias Infecciosas, Hospital do Servidor Publico; Estadual de Sao Paulo (HSPE).; Primary multidrug-resistant Mycobacterium tuberculosis is an important problem in the United States . There is no report in formal literature of this pathogen in Brazilian patients. CASE REPORT--We report a case of ganglionar tuberculosis diagnosed by acid-fast smears in a male, HIV pos
Inhibition of dipeptidyl peptidase IV (DP IV) by anti-DP IV antibodies and non-substrate X-X-Pro- oligopeptides ascertained by capillary electrophoresis.: J Chromatogr A. 1995 Nov 17;716(1-2):355-62. Unique Identifier : AIDSLINE MED/96104282; Hoffmann T; Reinhold D; Kahne T; Faust J; Neubert K; Frank R; Ansorge S; Center of Internal Medicine, Otto-von-Guericke University; Magdeburg, Germany.; Dipeptidyl peptidase IV (DP IV)-catalyzed hydrolysis of the NH2-X-Pro-containing N-terminal dodecapeptide of IL-2 was studied using free zone capillary electrophoresis as an alternative peptidase assay. In contrast to the conventional DP IV substrate glycyl-prolyl-p-ni
Drug-resistant tuberculosis: mechanisms and management.: Br J Hosp Med. 1995 Nov 15-Dec 12;54(10):494-500. Unique Identifier : AIDSLINE MED/96161529; Hayward CM; Herrman JL; Griffin GE; Division of Infectious Diseases, St George's Hospital Medical; School, London.; Infection with Mycobacterium tuberculosis remains a major global health problem and the recent outbreaks of multidrug resistant (MDR) tuberculosis have been a major cause for concern. An accurate picture of the extent of this problem is not possible because only a limited number of countries have reliable surveillance
Glycosylation inhibitors in biology and medicine.: Curr Opin Struct Biol. 1995 Oct;5(5):605-11. Unique Identifier : AIDSLINE MED/96127424; Jacob GS; GD Searle, St Louis, USA.; Glycosidase inhibitors are moving increasingly out of the laboratory and into the clinic as potential agents for the treatment of diseases including diabetes, AIDS and cancer. These compounds, originally isolated from natural sources and utilized for unraveling the glycosylation pathways involved in post-translational
Laboratory tests for detection of human immunodeficiency virus type 1 infection.: Clin Diagn Lab Immunol. 1995 Nov;2(6):637-45. Unique Identifier : AIDSLINE MED/96157362; Nuwayhid NF; Department of Veterans Affairs Medical Center, Department of; Internal Medicine, Amarillo, USA.
Detection of human immunodeficiency virus type 1-specific memory cytotoxic T lymphocytes in freshly donated and frozen-thawed peripheral blood mononuclear cells.: Clin Diagn Lab Immunol. 1995 Nov;2(6):678-84. Unique Identifier : AIDSLINE MED/96157368; Huang XL; Fan Z; Liebmann J; Rinaldo C; Department of Infectious Diseases and Microbiology, University of; Pittsburgh Graduate School of Public Health, Pennsylvania 15261,; USA.; Loss of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte (CTLm) responses is associated with disease progression in HIV-1 infection. In this study, nonspecific stimulation of peripheral blood mononuclear cells (PBMC) from HIV-1-infected homosexual men with anti-CD3 monoclonal antibody (MA
Dysregulated production of interleukin-10 (IL-10) and IL-12 by peripheral blood lymphocytes from human immunodeficiency virus-infected individuals is associated with altered proliferative responses to recall antigens.: Clin Diagn Lab Immunol. 1995 Nov;2(6):712-8. Unique Identifier : AIDSLINE MED/96157376; Daftarian MP; Diaz-Mitoma F; Creery WD; Cameron W; Kumar A; Department of Pediatrics, Children's Hospital of Eastern Ontario,; University of Ottawa, Canada.; The loss of immune function following infection with human immunodeficiency virus (HIV) may result from altered production of immunoregulatory cytokines such as interleukin-10 (IL-10) and IL-12. In this study, we analyzed IL-10 and IL-12 production by mitogen-stimulated peripheral blood mononuclear cells (PBMC) from H
Mouse Eotaxin expression parallels eosinophil accumulation during lung allergic inflammation but it is not restricted to a Th2-type response.: Immunity. 1996 Jan;4(1):1-14. Unique Identifier : AIDSLINE GENBANK/U40672; Ganzalo JA; Jia GQ; Aguirre V; Friend D; Coyle AJ; Jenkins NA; Lin GS; Katz H; Lichtman A; Copeland N; Kopf M; Gutierrez-Ramos JC; Center for Blood Research, Incorporated, Boston, Massachusetts; 02115, USA.; A model of lung eosinophilia based on the repeated exposure of mice to aerosolized OVA has been used to identify C-C chemokine genes expressed at stages of massive eosinophil infiltration. We describe the identification and cloning of a cDNA that encodes a mouse C-C chemokine with 68% amino acid identity to guinea pig
Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes.: Immunity. 1996 Jan;4(1):25-36. Unique Identifier : AIDSLINE GENBANK/J03590; Guidotti LG; Ishikawa T; Hobbs MV; Matzke B; Schreiber R; Chisari FV; Department of Molecular and Experimental Medicine, Scripps; Research Institute, La Jolla, California 92037, USA.; It is widely believed that viral clearance is mediated principally by the destruction of infected cells by CTLs. In this report, we use a transgenic mouse model of HBV replication to demonstrate that this assumption may not be true for all viruses. We find that adoptively transferred virus-specific CTLs can abolish HB
Single-cell PCR analysis of TCR repertoires selected by antigen in vivo: a high magnitude CD8 response is comprised of very few clones.: Immunity. 1996 Jan;4(1):47-55. Unique Identifier : AIDSLINE MED/96158750; Maryanski JL; Jongeneel CV; Bucher P; Casanova JL; Walker PR; Ludwig Institute for Cancer Research, Swiss Institute for; Experimental Cancer Research, Epalinges, Switzerland.; Taking advantage of a potent MHC class I-restricted response that allows the identification of antigen-selected CD8 T cells directly ex vivo, we characterized the antigen-specific T cell repertoires that develop in individual mice by single-cell PCR analysis. Each of the immune mice displayed distinct yet structurally
The real Kaposi's sarcoma [letter]: Nat Med. 1996 Feb;2(2):131. Unique Identifier : AIDSLINE MED/96160350; Breimer LH
AIDS physicians find support in the trenches [news]: Nat Med. 1996 Feb;2(2):140. Unique Identifier : AIDSLINE MED/96160353; Kedar I
A complement-ary AIDS vaccine.: Nat Med. 1996 Feb;2(2):153-5. Unique Identifier : AIDSLINE MED/96160356; Dierich MP; Stoiber H; Clivio A; Institut fur Hygiene and Ludwig Boltzmann Institut fur; AIDS-Forschung, Innsbruck, Austria.; The human immunodeficiency virus uses the human complement system to its advantage. Is it possible to turn the tables with a vaccine?
A lesson from the HIV patient: the immune response is still the bane (or promise) of gene therapy [comment]: Nat Med. 1996 Feb;2(2):165-7. Unique Identifier : AIDSLINE MED/96160362; Koenig S; MedImmune, Inc, Gaithersburg, Maryland 20878, USA.
T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients [see comments]: Nat Med. 1996 Feb;2(2):216-23. Unique Identifier : AIDSLINE MED/96160371; Riddell SR; Elliott M; Lewinsohn DA; Gilbert MJ; Wilson L; Manley SA; Lupton SD; Overell RW; Reynolds TC; Corey L; Greenberg PD; Fred Hutchinson Cancer Research Center, Seattle, Washington; 98104, USA.; The introduction and expression of genes in somatic cells is an innovative therapy for correcting genetic deficiency diseases and augmenting immune function. A potential obstacle to gene therapy is the elimination of such gene-modified cells by an immune response to novel protein products of the introduced genes. We a
Bovine beta-lactoglobulin modified by 3-hydroxyphthalic anhydride blocks the CD4 cell receptor for HIV.: Nat Med. 1996 Feb;2(2):230-4. Unique Identifier : AIDSLINE MED/96160373; Neurath AR; Jiang S; Strick N; Lin K; Li YY; Debnath AK; Laboratory of Biochemical Virology, Lindsley F. Kimball Research; Institute of the New York Blood Center, New York 10021, USA.; Sexual transmission is the most frequent (86%) route of adult HIV-1 transmission worldwide. In the absence of a prophylactic anti-HIV vaccine, other methods of preventing infection should be implemented. Virucidal spermicides have been considered for this purpose, but their application is contraindicated by adverse ef
[Construction and expression of the gene CD4V1V2-PE40, coding for a molecular targeted protein against AIDS]: Chung Kuo I Hsueh Ko Hsueh Yuan Hsueh Pao. 1995 Aug;17(4):248-52. Unique Identifier : AIDSLINE MED/96147920; Zhao X; Zhang M; Li H; Lu S; Institute of Medicinal Biotechnology, CAMS, Beijing.; We here replaced the cell-binding domain in Pseudomonas exotoxin A (PE) with HIV-binding portion of CD4V1V2 molecule and constructed a chimeric gene CD4V1V2-PE40, which can be expressed in E. coli. The hybrid protein displays targeting toxicity toward cells infected by HIV and thus represents a promising novel therape
CD4+ T-lymphocytopenia without HIV infection: increased prevalence among patients with primary Sjogren's syndrome.: Clin Exp Rheumatol. 1995 Sep-Oct;13(5):609-16. Unique Identifier : AIDSLINE MED/96127306; Kirtava Z; Blomberg J; Bredberg A; Henriksson G; Jacobsson L; Manthorpe R; Sjogren's Syndrome Research Centre, Department of Rheumatology,; Malmo University Hospital, Sweden.; OBJECTIVE. Primary Sjogren s syndrome (1 degree SS) is an autoimmune disease, usually accompanied by manifest immune hyperactivity. In some cases the disease converts to malignant neoplasia. On the other hand, there are clinical similarities to HIV infection. Since the rare phenomenon of persistent depletion of CD4+ T
Screening imperfections [letter]: Cornea. 1995 Nov;14(6):589-90. Unique Identifier : AIDSLINE MED/96155576; Heck EL
Cytomegalovirus keratitis after penetrating keratoplasty.: Cornea. 1995 Nov;14(6):628-33. Unique Identifier : AIDSLINE MED/96155585; Wehrly SR; Manning FJ; Proia AD; Burchette JL; Foulks GN; Department of Ophthalmology, Duke University Medical Center,; Durham, North Carolina 27710, USA.; We report the development of cytomegalovirus ( CMV ) keratitis in the penetrating keratoplasty of a 59-year-old human immunodeficiency virus-negative woman after uncomplicated corneal transplantation. Immunosuppression with top
The CD4 molecule. Roles in T lymphocytes and in HIV disease. Introduction.: Curr Top Microbiol Immunol. 1996;205:v-x. Unique Identifier : AIDSLINE MED/96148081; Littman DR
The structure of CD4.: Curr Top Microbiol Immunol. 1996;205:1-18. Unique Identifier : AIDSLINE SWISSPROT; Brady RL; Barclay AN; Department of Biochemistry, University of Bristol, University; Walk, UK.
Endocytic and exocytic regulation of CD4 expression and function.: Curr Top Microbiol Immunol. 1996;205:107-35. Unique Identifier : AIDSLINE MED/96148087; Marsh M; Pelchen-Matthews A; Medical Research Council Laboratory for Molecular Cell Biology,; University College London, UK.
The receptor for HIV: dissection of CD4 and studies on putative accessory factors.: Curr Top Microbiol Immunol. 1996;205:137-58. Unique Identifier : AIDSLINE MED/96148088; James W; Weiss RA; Simon JH; Sir William Dunn School of Pathology, University of Oxford, UK.
The role of CD4 in HIV envelope-mediated pathogenesis.: Curr Top Microbiol Immunol. 1996;205:159-79. Unique Identifier : AIDSLINE MED/96148089; Siliciano RF; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, MD 21205, USA.; There is now compelling evidence that env-CD4 interactions are central to several complex pathogenic mechanisms in HIV-1 infection. In addition to mediating virus attachment to CD4+ cells, the high affinity interaction of env protein with CD4 is also important in initiating both syncytium formation and syncytium-indep
Anti-dorsalizing morphogenetic protein is a novel TGF-beta homolog expressed in the Spemann organizer.: Development. 1995 Dec;121(12):4293-301. Unique Identifier : AIDSLINE GENBANK/U22155; Moos M Jr; Wang S; Krinks M; Center for Biologics Evaluation and Research, Food and Drug; Administration, Rockville, MD 20852-1448, USA.; We have identified a novel growth factor in Xenopus, which is most closely related to human Bone Morphogenetic Protein-3. Its expression peaks during gastrulation, most prominently in the Spemann organizer, and persists in the posterior neural floor plate and prechordal plate during neurulation. Injection of the corre
Expression and characterization of the reverse transcriptase enzyme from type 1 human immunodeficiency virus using different baculoviral vector systems.: Eur J Biochem. 1995 Dec 15;234(3):811-8. Unique Identifier : AIDSLINE MED/96163464; Pekrun K; Petry H; Jentsch KD; Moosmayer D; Hunsmann G; Luke W; Department for Virology and Immunology, German Primate Centre,; Gottingen, Germany.; To produce the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) in amounts required to study its structure and function, the p66 enzyme subunit was expressed using two different baculovirus vectors in Sf158 insect host cells. Both vectors permitted an efficient HIV-1 RT expression. The resulting
Binding of distamycin and chromomycin to human immunodeficiency type 1 virus DNA: a non-radioactive automated footprinting study.: Eur J Pharmacol. 1995 Jul 18;290(2):85-93. Unique Identifier : AIDSLINE MED/96171855; Feriotto G; Mischiati C; Bianchi N; Passadore M; Gambari R; Biotechnology Centre, Ferrara University, Italy.; Sequence-selectivity of DNA-binding drugs was recently reported in a number of studies employing footprinting and gel retardation approaches. In this paper we studied sequence-selectivity of the binding of chromomycin and distamycin to DNA by performing DNase I footprinting and analysis of the cleaved fragments by the
Clinical characteristics and outcome of Pneumocystis carinii pneumonia in HIV-infected and otherwise immunosuppressed patients.: Eur Respir J. 1995 Sep;8(9):1548-53. Unique Identifier : AIDSLINE MED/96120041; Ewig S; Bauer T; Schneider C; Pickenhain A; Pizzulli L; Loos U; Luderitz B; Department of Internal Medicine, University of Bonn, Germany.; The factors contributing to unequal mortality rates following Pneumocystis carinii pneumonia (PCP) in different groups at risk are poorly understood. We therefore compared the first episodes of PCP without prophylaxis in human immunodeficiency virus infected (HIV) and otherwise immunosuppressed patients in this retros
Cost-analysis of four diagnostic strategies for Pneumocystis carinii pneumonia in HIV-infected subjects.: Eur Respir J. 1995 Sep;8(9):1554-8. Unique Identifier : AIDSLINE MED/96120042; Chouaid C; Housset B; Lebeau B; Service de Pneumologie, Hopital Saint Antoine, Paris, France.; The aim of this study was to analyse the cost-effectiveness ratio of four diagnostic strategies for Pneumocystis carinii pneumonia (PCP) in patients infected with human immunodeficiency virus (HIV). Two hundred and ten HIV-infected patients with suspected PCP underwent induced-sputum (IS) followed, if negative, by bro
[World Health Report shows children as the sad losers. Almost 10 million AIDS orphans can be expected (news)]: Fortschr Med. 1995 Dec 10;113(34):18-9. Unique Identifier : AIDSLINE MED/96141489; Knauer RH
[With interferon and zidovudine against therapy refractory T-cell leukemias (news)]: Fortschr Med. 1995 Dec 10;113(34):8. Unique Identifier : AIDSLINE MED/96141487; Sauer H; Medizinische Klinik III, Klinikum Grosshadern,; Ludwig-Maximilians-Universitat, Munchen.
Histological study of oxalosis in the eye and adnexa of AIDS patients.: Histopathology. 1995 Nov;27(5):431-8. Unique Identifier : AIDSLINE MED/96154642; Pecorella I; McCartney AC; Lucas S; Michaels L; Ciardi A; Di Tondo U; Garner A; Department of Pathology, University College London Medical; School, UK.; Review of a series of 98 eyes removed at autopsy from 86 AIDS patients identified 12 cases (14%) showing varying degrees of microscopic calcium oxalate deposition. The oxalate crystals were birefringent using polarisation microscopy and were stained histochemically by the silver nitrate-rubeanic acid method (Yasue), a
Retrovirus-induced lymphoproliferative disease in mice undergoing graft-versus-host reaction.: Immunol Invest. 1995 Nov;24(6):881-90. Unique Identifier : AIDSLINE MED/96153653; Cunningham RK; Thacore HR; Zhou P; Nakeeb S; Zaleski MB; Ernest Witebsky Center for Immunology, School of Medicine and; Biomedical Sciences, State University of New York, Buffalo; 14214-3078, USA.; The effect of graft-versus-host reaction on the course of concommitant retrovirus-induced lymphoproliferative disease was investigated. The graft-versus-host reaction was elicited by a single i.v. injection of 1.2 x 10(8) parental spleen cells into adult F1 mice. Lymphoproliferative disease was induced by a single tra
CD8+ T cell subsets in aging.: Immunol Invest. 1995 Nov;24(6):891-5. Unique Identifier : AIDSLINE MED/96153654; Ruiz M; Esparza B; Perez C; Barranquero M; Sabino E; Merino F; School of Medicine, Universidad del Pais Vasco, Leioa, Vizcaya,; Spain.; Infections are major cause of illness and death amongst elderly people. Peripheral blood CD8+ T lymphocytes -which play a crucial role in host defence against viral infections-. are divided in subsets based upon the expression of several cell and activation markers. Since in senescence changes in peripheral blood CD8+
Altered in vitro handling of Mycobacterium avium complex by monocytes and serum from HIV(+) patients.: Immunol Invest. 1995 Nov;24(6):987-98. Unique Identifier : AIDSLINE MED/96153662; Swartz RP; Roecklein JA; Pierce PF Jr; Yeager H Jr; Department of Medicine, Georgetown University Medical Center,; Washington, DC 20007, USA.; In patients with acquired immunodeficiency syndrome (AIDS), mycobacterial diseases are leading opportunistic infections. The reasons for the peculiar propensity for disseminated infection with Mycobacterium avium complex (MAC) remain unclear. We have previously examined, in detail, the ability of monocytes from health
ICN task force concerned about HIV/AIDS work risks [news]: Int Nurs Rev. 1995 Sep-Oct;42(5):132. Unique Identifier : AIDSLINE MED/96111314
Long-term HIV survivors in the spotlight [news]: Int Nurs Rev. 1995 Sep-Oct;42(5):140. Unique Identifier : AIDSLINE MED/96171716
A review of patients on methadone maintenance.: Ir Med J. 1995 Nov-Dec;88(6):218-9. Unique Identifier : AIDSLINE MED/96166126; Taj R; Keenan E; O'Connor JJ; Dept. of Psychiatry, Mater Hospital, Dublin.; This study involves a review of 178 patients on a strictly monitored methadone maintenance programme. All patients had a minimum of 9 years of intravenous drug misuse. 35.7% were HIV positive, 55.7% males and 29% females had previous prison sentences. On average patients had undergone 3.26 out-patient and 0.9 in-patie
The metal ion-induced cooperative binding of HIV-1 integrase to DNA exhibits a marked preference for Mn(II) rather than Mg(II).: J Biol Chem. 1996 Jan 19;271(3):1498-506. Unique Identifier : AIDSLINE MED/96139481; Pemberton IK; Buckle M; Buc H; Unite de Physicochimie des Macromolecules Biologiques CNRS URA; 1149, Institut Pasteur, Paris, France.; In this investigation, we examine the interaction between the human immunodeficiency virus type I integrase and oligonucleotides that reflect the sequences of the extreme termini of the viral long terminal repeats (LTRs). The results of gel filtration and a detailed binding density analysis indicate that the integrase
Complete inhibition of human immunodeficiency virus Gag myristoylation is necessary for inhibition of particle budding.: J Biol Chem. 1996 Feb 2;271(5):2868-73. Unique Identifier : AIDSLINE MED/96162038; Morikawa Y; Hinata S; Tomoda H; Goto T; Nakai M; Aizawa C; Tanaka H; Omura S; Kitasato Institute, Tokyo, Japan.; Myristoylation of human immunodeficiency virus (HIV) Gag protein is essential for virus particle budding. Two reactions are involved; activation of free myristate to myristoyl-CoA and transfer of the myristoyl residue to the Gag N-terminal glycine. We have investigated the effects of triacsin C, an inhibitor of long c
Colorimetric microtiter plate hybridization assay using monoclonal antibody for detection of an amplified human immunodeficiency virus target.: J Virol Methods. 1995 Sep;55(1):145-51. Unique Identifier : AIDSLINE MED/96089778; Ferre-Aubineau V; Imbert-Marcille BM; Raffi F; Besse B; Loirat R; Billaudel S; Virology Laboratory, Nantes University Hospital, France.; Since detection of amplified polymerase chain reaction products is a complicated procedure, a colorimetric microtiter plate hybridization assay was developed to automate specific detection of amplified HIV targets. In this assay, hybridization is seen by an antibody reacting selectively with double-stranded DNA. One h
Evaluation of the reliability of 6 current anti-HIV-1/HIV-2 enzyme immunoassays.: J Virol Methods. 1995 Sep;55(1):97-104. Unique Identifier : AIDSLINE MED/96089773; Weber B; Moshtaghi-Boronjeni M; Brunner M; Preiser W; Breiner M; Doerr HW; Institut fur Medizinische Virologie, Universitatskliniken,; Frankfurt/M., Germany.; The sensitivity for early detection of HIV antibodies and specificity of 6 anti-HIV-1/HIV-2 screening enzyme immunoassays (ELISAs) currently on the market were investigated by testing a panel of 249 well-characterized serum samples. The panel included sera from AIDS patients or children with congenital HIV infection,
Inhibitory effect of the immunosuppressant FK506 on apoptotic cell death induced by HIV-1 gp120.: J Clin Immunol. 1995 Nov;15(6):312-7. Unique Identifier : AIDSLINE MED/96159697; Sekigawa I; Koshino K; Hishikawa T; Kaneko H; Takasaki Y; Hashimoto H; Hirose S; Inagaki Y; Yamamoto N; Department of Medicine, Juntendo University, School of Medicine,; Tokyo, Japan.; Human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 may play a central role in inducing immunoregulatory disorders after HIV infection. The apoptotic death of normal human peripheral blood mononuclear cells was induced by priming with gp120 followed by stimulation with an anti-T cell receptor (TCR)
CD4+ Th2 cell response cytokine production in bacterial meningitis.: J Clin Immunol. 1995 Nov;15(6):338-48. Unique Identifier : AIDSLINE MED/96159700; Raziuddin S; el-Awad ME; Telmesani AW; Bilal NE; al-Janadi M; King Faisal Specialist Hospital & Research Center, Riyadh, Saudi; Arabia.; There has been a growing body of evidence suggesting that CD4+ Th1/Th2 cell responses participate in pathologic and immunologic processes in infectious disease. Bacterial meningitis is a fatal disease of children and is associated with a spectrum of clinical syndromes. This study provides evidence of CD4+ enhanced int
Mycobacterium conspicuum sp. nov., a new species isolated from patients with disseminated infections.: J Clin Microbiol. 1995 Nov;33(11):2805-11. Unique Identifier : AIDSLINE GENBANK/X88922; Springer B; Tortoli E; Richter I; Grunewald R; Rusch-Gerdes S; Uschmann K; Suter F; Collins MD; Kroppenstedt RM; Bottger EC; Institut fur Medizinische Mikrobiologie, Medizinische Hochschule; Hannover.; A new type of slowly growing, nonphotochromogenic mycobacterium was recovered from two patients with disseminated disease. The growth characteristics, acid fastness, acids were consistent with those for Mycobacterium species. The results of biochemical investigations, lipid analyses, and comparative 16S rRNA sequencin
Performance of a rapid, on-site human immunodeficiency virus antibody assay in a public health setting.: J Clin Microbiol. 1995 Nov;33(11):2899-902. Unique Identifier : AIDSLINE MED/96121237; Kassler WJ; Haley C; Jones WK; Gerber AR; Kennedy EJ; George JR; Division of STD/HIV Prevention, Centers for Disease Control and; Prevention, Atlanta, Georgia, USA.; Rapid, on-site human immunodeficiency virus (HIV) testing has the potential to improve the delivery of prevention services in publicly funded counseling and testing sites. The Single Use Diagnostic System (SUDS) HIV-1 is the only rapid enzyme immunoassay (EIA) approved for diagnostic use in the
Disseminated Encephalitozoon (Septata) intestinalis infection in a patient with AIDS: novel diagnostic approaches and autopsy-confirmed parasitological cure following treatment with albendazole.: J Clin Microbiol. 1995 Nov;33(11):2948-52. Unique Identifier : AIDSLINE MED/96121246; Sobottka I; Albrecht H; Schafer H; Schottelius J; Visvesvara GS; Laufs R; Schwartz DA; Department of Medicine, University Hospital Eppendorf, Hamburg,; Germany.; Encephalitozoon intestinalis is a recently described microsporidian which causes intestinal and disseminated infections in severely immunocompromised patients with AIDS. Preliminary data suggest that albendazole can be an effective therapy for patients with E. intestinalis infection. However, relapses have been report
Geographical clustering of human T-cell lymphotropic virus type 1 infection in Honduras.: J Clin Microbiol. 1995 Nov;33(11):2999-3003. Unique Identifier : AIDSLINE MED/96121256; de Rivera IL; Amador L; Mourra S; Li Z; Rasheed S; Laboratory of Viral Oncology and AIDS Research, University of; Southern California, School of Medicine, Los Angeles 90032, USA.; Geographical clustering of human T-cell lymphotropic virus type 1 (HTLV-1) infection has been identified in the nonmestizo communities in several cities along the Atlantic coast of Honduras . Of the 2,651 serum samples tested, 122 sa
Comparison of PCR and standard cytological staining for detection of Pneumocystis carinii from respiratory specimens from patients with or at high risk for infection by human immunodeficiency virus.: J Clin Microbiol. 1995 Nov;33(11):3004-7. Unique Identifier : AIDSLINE MED/96121257; Leibovitz E; Pollack H; Moore T; Papellas J; Gallo L; Krasinski K; Borkowsky W; Department of Pediatrics, New York University Medical Center, New; York 10016, USA.; The detection of Pneumocystis carinii DNA by PCR was compared with routine cytologic staining techniques (CYT). A total of 284 clinical respiratory specimens, including 137 bronchoalveolar lavage (BAL), 63 bronchoalveolar washing, 63 sputum, and 21 induced sputum samples, obtained from patients with or at high risk fo
PCR as a confirmatory test for human immunodeficiency virus type 1 infection in individuals with indeterminate western blot (immunoblot) profiles.: J Clin Microbiol. 1995 Nov;33(11):3034-6. Unique Identifier : AIDSLINE MED/96121264; Sethoe SY; Ling AE; Sng EH; Monteiro EH; Chan RK; Department of Pathology, Singapore General Hospital, Republic of; Singapore.; A combination of two PCR systems which amplify human immunodeficiency virus type 1 (HIV-1) gag and pol DNA was used to elucidate the HIV-1 infection status of a group of individuals screening positive for anti-HIV but having indeterminate Western blot (immunoblot) profiles. The results obtained suggest PCR could be us
Intestinal cytomegalovirus disease in immunocompromised patients may be ruled out by search for cytomegalovirus DNA in stool samples.: J Clin Microbiol. 1995 Nov;33(11):3064-7. Unique Identifier : AIDSLINE MED/96121274; Michel D; Marre E; Hampl W; Roczkos J; Muller S; Hertenstein B; Kern P; Heymer B; Salzberger B; Arasteh K; et al; Abteilung Virologie, Universitatsklinik Ulm, Innere Medizin,; Klinikum I, Universitat zu Koln, Germany.; Cytomegalovirus ( CMV ) PCR from stool specimens was adopted as a diagnostic tool for patients with suspected CMV colitis. After being established, the method was evaluated in 17 AIDS patients and 19 other immunocompromised patients by comparison of PCR results wi
Carnitine in human immunodeficiency virus type 1 infection/acquired immune deficiency syndrome.: J Child Neurol. 1995 Nov;10 Suppl 2:S40-4. Unique Identifier : AIDSLINE MED/96155690; Mintz M; University of Medicine and Dentistry of New Jersey-Robert Wood; Johnson Medical School at Camden 08103, USA.; There is an increasing body of evidence that subgroups of patients infected with human immunodeficiency virus type 1 possess carnitine deficiency. Secondary carnitine deficiencies in these individuals may result from nutritional deficiencies, gastrointestinal disturbances, renal losses, or shifts in metabolic pathways
Binding kinetics of an antibody against HIV p24 core protein measured with real-time biomolecular interaction analysis suggest a slow conformational change in antigen p24.: J Immunol Methods. 1996 Jan 16;189(1):1-14. Unique Identifier : AIDSLINE MED/96163539; Glaser RW; Hausdorf G; Department of Medical Immunology, Humboldt University Berlin,; Medical School (Charite), Germany.; The interaction between HIV core protein p24 and the murine monoclonal antibody CB-4/1 or its Fab fragment showed unusual kinetics. Recombinant p24 was immobilised in a hydrophilic carboxymethyldextran matrix. At high concentration of CB-4/1 Fab the association of the antigen-antibody complex proceeds in two phases, w
Production of IL-8 and IL-4 by positively and negatively selected CD4+ and CD8+ human T cells following a four-step cell separation method including magnetic cell sorting (MACS).: J Immunol Methods. 1996 Jan 16;189(1):107-15. Unique Identifier : AIDSLINE MED/96163550; Stanciu LA; Shute J; Holgate ST; Djukanovic R; Immunopharmacology Group, General Hospital, Southampton, UK.; Highly enriched CD4+ and CD8+ human T cells were obtained from peripheral blood using a relatively simple and inexpensive method consisting of four steps: separation of mononuclear cells on Lymphoprep, removal of adherent monocytes by incubation in plastic petri dishes, removal of B cells, NK cells and further depleti
Analysis of alloreactive helper T lymphocyte precursor frequencies. Influence of interleukin-2 produced by the stimulating cells.: J Immunol Methods. 1996 Jan 16;189(1):65-72. Unique Identifier : AIDSLINE MED/96163545; Reisaeter AV; Thorsby E; Brinchmann JE; Institute of Transplantation Immunology, National Hospital, Oslo,; Norway.; In the determination of alloreactive helper T lymphocyte precursor frequencies (HTLpf) by limiting dilution analysis (LDA), peripheral blood mononuclear cells (PBMC) are used as stimulating cells. Interleukin-2 ( IL-2 ) production by stimulating T cells constitute a sour
A therapeutic community for HIV-infected persons: an approach for prevention and control of AIDS.: J Med Assoc Thai. 1995 Oct;78(10):559-64. Unique Identifier : AIDSLINE MED/96108081; Warnnissorn T; Department of Communicable Disease Control, Ministry of Public; Health, Nonthaburi, Thailand.; The Therapeutic Community (TC) for HIV-infected persons is neither a hospital nor a confinement for people with HIV. Actually it is a family of friends who are in the same boat and a place of education to teach them about AIDS and relevant subjects necessary for their life in the future, and to help establish new valu
Seroprevalence of anti-HCV among HIV-infected persons and general population.: J Med Assoc Thai. 1995 Nov;78(11):611-7. Unique Identifier : AIDSLINE MED/96108090; Suwanagool S; Tieangrim S; Ratanasuwan W; Mekanantagosol S; Luengrojanakul P; Kunasol P; Department of Preventive and Social Medicine, Faculty of; Medicine, Siriraj Hospital, Mahidol University, Bangkok,; Thailand.; From November 1993 to December 1994, the seroprevalence of anti-HCV, HBsAg was studied among 346 HIV-infected persons (asymptomatic HIV-infected persons and AIDS patients) and 1,023 subjects from the general population (including 119 cord blood samples). The prevalence of anti-HCV, HBsAg among HIV-infected patients ag
Preliminary survey of anti-HTLV-I in northeastern-Thais.: J Med Assoc Thai. 1995 Nov;78(11):628-30. Unique Identifier : AIDSLINE MED/96108093; Burusrux S; Urwijitaroon Y; Romphruk A; Puapairoj C; Faculty of Associated Medical Sciences, Khon Kaen University,; Thailand.; The anti-HTLV-I prevalence was studied by particle agglutination technique (PA) in 2,609 samples including: 403 antenatal care women from Srinagarind Hospital, Faculty of Medicine, 342 high-risk sexually transmitted disease blood donors and 1,864 randomly selected blood donors from the Blood Transfusion Centre, Facult
Extensive esophageal candidiasis in the absence of oral lesions in pediatric AIDS.: J Pediatr Gastroenterol Nutr. 1995 Jul;21(1):104-6. Unique Identifier : AIDSLINE MED/96171708; Braegger CP; Albisetti M; Nadal D; Gastroenterology Unit, Children's Hospital, University of Zurich,; Switzerland.
An approach to rapid estimation of relative binding affinities of enzyme inhibitors: application to peptidomimetic inhibitors of the human immunodeficiency virus type 1 protease.: J Med Chem. 1996 Feb 2;39(3):705-12. Unique Identifier : AIDSLINE MED/96160895; Viswanadhan VN; Reddy MR; Wlodawer A; Varney MD; Weinstein JN; Laboratory of Molecular Pharmacology, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892, USA.; This report describes a method for rapid assessment of the binding affinities of a series of analogous ligands to an enzyme. This approach is based on two variables (scores), representing (i) the enthalpy of binding and (ii) the strength of hydrophobic interaction. The method is then used to evaluate the binding of 11
Early nutrition support modifies immune function in patients sustaining severe head injury.: JPEN J Parenter Enteral Nutr. 1995 Sep-Oct;19(5):387-92. Unique Identifier : AIDSLINE MED/96105875; Sacks GS; Brown RO; Teague D; Dickerson RN; Tolley EA; Kudsk KA; Department of Clinical Pharmacy, University of Tennessee, Memphis; 38163, USA.; BACKGROUND: Immunosuppression after severe head injury has been characterized by a depressed CD4 (T-helper/inducer)-CD8 (T-suppressor/cytotoxic) ratio and decreased T-lymphocyte responsiveness. Some investigators propose that this immunocompromized state is the result of an injury-associated hypermetabolic response an
Gastrointestinal surface protection and mucosa reconditioning.: JPEN J Parenter Enteral Nutr. 1995 Sep-Oct;19(5):410-5. Unique Identifier : AIDSLINE MED/96105880; Bengmark S; Jeppsson B; Department of Surgery, Lund University, Sweden.; BACKGROUND: There is increasing evidence that preservation of the ecology of the gastrointestinal tract and the surface protection system--surfactants, mucus, and fiber--is important for the outcome in postoperative trauma patients, patients after bone marrow and liver transplantation, and patients with HIV or AIDS. A
[The clinical picture of mycotic complications in HIV-infected patients]: Klin Med (Mosk). 1995;73(3):44-7. Unique Identifier : AIDSLINE MED/96171823; Rakhmanova AG; Giaurgieva OKh; Gorshkov GI; Mycotic complications were registered in 21 out of 37 HIV-infected subjects. Oropharyngeal candidiasis was most common. It occurred prior to or concurrently with esophageal and skin candidiasis, fungemia, meningoencephalitis and disseminated lesions. With immunodeficiency progression, the prevalence and severity of my
Radiotherapy for oral manifestations of Kaposi's sarcoma [letter]: Mayo Clin Proc. 1996 Feb;71(2):213. Unique Identifier : AIDSLINE MED/96165374; Miller RC; Martenson JA; Petersen IA
Radiotherapy for oral manifestations of Kaposi's sarcoma [letter]: Mayo Clin Proc. 1996 Feb;71(2):213. Unique Identifier : AIDSLINE MED/96165375; Narasimhan P; Hitti I
Three antigenic regions in p17 of human immunodeficiency virus type 1 (HIV-1) revealed by mouse monoclonal antibodies and human antibodies in HIV-1 carrier sera.: Microbiol Immunol. 1995;39(10):775-85. Unique Identifier : AIDSLINE MED/96156439; Liu X; Ota A; Watanabe M; Ueda S; Saitoh A; Shinagawa H; Nakata A; Kurimura T; Wang X; Zhao Y; et al; Department of Immunochemistry, Research Institute for Microbial; Diseases, Osaka University, Japan.; We investigated the murine antibody response to recombinant p17 (rp17) of human immunodeficiency virus type 1 (HIV-1) and the human antibody response directed to p17 in HIV-1 infection. Three large peptides covering residues 12-29, 53-87 and 87-115 of p17 were synthesized. The cysteine residues 57 and 87 of peptide 53
Suppression of cytokine production in T helper type 2 cells by nitric oxide in comparison with T helper type 1 cells.: Microbiol Immunol. 1995;39(9):709-14. Unique Identifier : AIDSLINE MED/96123367; Nukaya I; Takagi K; Kawabe T; Suketa Y; Department of Environmental Biochemistry, School of; Pharmaceutical Science, University of Shizuoka, Japan.; We examined the effect of nitric oxide (NO) on cytokine production in T helper (Th) cell subsets, using murine splenic CD4+ T cells and two types of Th clones. Interferon-gamma-treated murine peritoneal exudate cells (IFN-PEC) suppressed DNA synthesis to 60% of the control level in CD4+ T cells stimulated with the ant
A new approach to antiviral therapy.: Med Hypotheses. 1995 Oct;45(4):375-9. Unique Identifier : AIDSLINE MED/96153542; Peuschel KE; A new approach to antiviral therapy is proposed, taking advantage of the recently investigated innervation of immune tissues by the sympathetic nervous system, which establishes a functional connection between the nervous and the immune system, where the sympathetic nervous system exerts a varying tonic inhibitory inf
Follicular dendritic cells productively infected with immunodeficiency viruses transmit infection to T cells.: Med Microbiol Immunol (Berl). 1995 Oct;184(3):129-34. Unique Identifier : AIDSLINE MED/96154932; Sprenger R; Toellner KM; Schmetz C; Luke W; Stahl-Hennig C; Ernst M; Hunsmann G; Schmitz H; Flad HD; Gerdes J; et al; Department of Immunology and Cell Biology, Forschung Institut; Borstel, Germany.; Lymphoid organs have been proposed to function as the major reservoir for the human immunodeficiency virus type 1 (HIV-1). Within lymphatic tissues germinal centers represent foci of rapidly proliferating B cells governed by the interaction between B and T cells and follicular dendritic cells (FDC). Accumulating evide
Clinical significance of resolution of chest X-ray findings in HIV-infected children with lymphocytic interstitial pneumonitis (LIP).: Pediatr Radiol. 1995 Nov;25 Suppl 1:S243-6. Unique Identifier : AIDSLINE MED/96171724; Prosper M; Omene JA; Ledlie; Odita JC; Department of Pediatrics, Woodhull Medical and Mental Health; Center, 760 Broadway, Brooklyn, NY 11206, USA.; Lymphocytic interstitial pneumonitis (LIP) in HIV-infected children is generally associated with better prognosis as compared with children with Pneumocystis carinii pneumonia (PCP). We prospectively studied 12 cases of HIV-infected children with LIP over a 4-year period in an effort to document one aspect of the natu
Trust demands HIV test for pool births [news]: Nurs Times. 1996 Jan 10-6;92(2):9. Unique Identifier : AIDSLINE MED/96161117; Day M
[The worldwide status of tuberculosis today]: Pneumologie. 1995 Dec;49 Suppl 3:633-5. Unique Identifier : AIDSLINE MED/96147388; Billo NE; Internationale Union gegen Tuberkulose und Lungenkrankheiten,; Paris, Frankreich.
[Therapeutic approaches in diseases caused by mycobacteria]: Pneumologie. 1995 Dec;49 Suppl 3:649-52. Unique Identifier : AIDSLINE MED/96147391; Urbanczik R; Med.-diagnostisches Institut der Fatol Arzneimittel GmbH,; Schiffweiler.; Following the historical introduction (the review by Schlossberger, 1928) the evolution of individual chemotherapy phases is briefly discussed. Then after following points are discussed. 1) The usual controlled clinical trials for evaluation of new drugs must be replaced (perhaps by estimates of the early bactericidal
Tuberculosis and HIV infection worldwide.: Pneumologie. 1995 Dec;49 Suppl 3:653-6. Unique Identifier : AIDSLINE MED/96147392; Murray JF; Division of Pulmonary and Critical Care Medicine, San Francisco; General Hospital Medical Center, University of California, USA.; The incidence of HIV-associated tuberculosis is increasing worldwide and will continue to increase during the foreseeable future, especially in developing countries. HIV infection appears to increase the opportunity for M. tuberculosis to succeed in causing infection after inhalation into the lungs. Moreover, there is
[Tuberculosis and radiologic diagnosis 100 years after W. C. Roentgen]: Pneumologie. 1995 Dec;49 Suppl 3:657-62. Unique Identifier : AIDSLINE MED/96147393; Felix R; Bittner RC; Strahlenklinik und Poliklinik, Virchow-Klinikum, Medizinische; Fakultat der Humboldt-Universitat zu Berlin.; The discovery of the x-rays by W. C. Roentgen 100 years ago significantly improved the diagnosis and follow-up of tuberculosis, therapy control became possible, and the basis for prevention was set by early detection. Within few years, the Roentgen rays had been made a triumphant progress around the world, and Roentge
Pentamidine-induced hyperglycemia and ketosis in acquired immunodeficiency syndrome [letter]: Pancreas. 1995 Oct;11(3):315-6. Unique Identifier : AIDSLINE MED/96100580; Lu CP; Wu HP; Chuang LM; Lin BJ; Chuang CY; Tai TY
Acute pancreatitis in an octreotide-treated AIDS patient--suggested alternative mechanisms [letter]: Pancreas. 1995 Oct;11(3):318-9. Unique Identifier : AIDSLINE MED/96100583; Harris AG; Caroli-Bosc FX; Demarquay JF; Hastier P; Delmont J
Empirical free energy calculations of ligand-protein crystallographic complexes. I. Knowledge-based ligand-protein interaction potentials applied to the prediction of human immunodeficiency virus 1 protease binding affinity.: Protein Eng. 1995 Jul;8(7):677-91. Unique Identifier : AIDSLINE MED/96156574; Verkhivker G; Appelt K; Freer ST; Villafranca JE; Agouron Pharmaceuticals Inc., San Diego, CA 92121-1121, USA.; The steadily increasing number of high-resolution human immunodeficiency virus (HIV) 1 protease complexes has been the impetus for the elaboration of knowledge-based mean field ligand-protein interaction potentials. These potentials have been linked with the hydrophobicity and conformational entropy scales developed o
Kruppel-associated box-mediated repression of RNA polymerase II promoters is influenced by the arrangement of basal promoter elements.: Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1015-20. Unique Identifier : AIDSLINE MED/96165510; Pengue G; Lania L; Department of Genetics, Molecular and General Biology, University; of Naples, Federico II, Italy.; The evolutionarily conserved Kruppel-associated box (KRAB) is present in the N-terminal regions of more than one-third of all Kruppel-class zinc finger proteins. Recent experiments have demonstrated that the KRAB-A domain tethered to a promoter DNA by connecting to heterologous DNA-binding protein domain or targeted t
The in vitro ejection of zinc from human immunodeficiency virus (HIV) type 1 nucleocapsid protein by disulfide benzamides with cellular anti-HIV activity.: Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):969-73. Unique Identifier : AIDSLINE MED/96165501; Tummino PJ; Scholten JD; Harvey PJ; Holler TP; Maloney L; Gogliotti R; Domagala J; Hupe D; Department of Biochemistry, Parke-Davis Pharmaceutical Research,; Division of Warner Lambert Co., Ann Arbor, MI 48105, USA.; Several disulfide benzamides have been shown to possess wide-spectrum antiretroviral activity in cell culture at low micromolar to submicromolar concentrations, inhibiting human immunodeficiency virus (HIV) type 1 (HIV-1) clinical and drug-resistant strains along with HIV-2 and simian immunodeficiency virus [Rice, W.
Inhibitors of HIV proteinase.: Prog Med Chem. 1995;32:239-87. Unique Identifier : AIDSLINE MED/96104349; Martin JA; Redshaw S; Thomas GJ; Roche Products Ltd., Welwyn Garden City, Herts, UK.
Possible role of bovine immunodeficiency virus in bovine paraplegic syndrome: evidence from immunochemical, virological and seroprevalence studies.: Res Virol. 1995 Sep-Oct;146(5):313-23. Unique Identifier : AIDSLINE MED/96151048; Walder R; Kalvatchev Z; Tobin GJ; Barrios MN; Garzaro DJ; Gonda MA; Laboratorio Virus Animales, Instituto Venezolano de; Investigaciones Cientificas (IVIC), Caracas.; Bovine paraplegic syndrome (BPS) is a debilitating cattle disease of unknown origin that is characterized by leukocytosis, lymphocytopenia and monocytopenia. The major clinical signs are difficulties in locomotion affecting hind limbs, hypoalgesia in the hind quarters, posterior paralysis and death within 72 to 96 hou
Poorly differentiated non-small cell carcinoma of the lung in acquired immunodeficiency syndrome.: Respiration. 1995;62(4):232-3. Unique Identifier : AIDSLINE MED/96039586; Mady BJ; Department of Medicine, University of Rochester, School of; Medicine and Dentistry, NY., USA.; Case of a 33-year-old female with AIDS who presented with fevers, chills, lower back pain and a large right hilar mass. Biopsy of the right paratracheal nodes revealed poorly differentiated non-small cell carcinoma with extensive necrosis. In patients infected with HIV the incidence of primary lung carcinoma is unknow
Benign lymphadenopathies in children and adolescents.: Semin Diagn Pathol. 1995 Nov;12(4):288-302. Unique Identifier : AIDSLINE MED/96156623; Segal GH; Perkins SL; Kjeldsberg CR; Department of Pathology, University of Utah Health Sciences; Center, Salt Lake City 84132, USA.; This article provides and overview of the benign causes of lymphadenopathy (LA) in the pediatric population. Because of the topics broad nature, this review is a selective one and primarily focuses on benign conditions of lymph nodes that may be confused with malignant disorders or have been described or better defin
Blastocystis hominis in human immunodeficiency virus-related diarrhea.: Scand J Gastroenterol. 1995 Sep;30(9):909-14. Unique Identifier : AIDSLINE MED/96117868; Albrecht H; Stellbrink HJ; Koperski K; Greten H; Medical Outpatient and Inpatient Clinics, Eppendorf University; Hospital, Hamburg, Germany.; BACKGROUND: A wide variety of bacterial, viral, and parasitic pathogens can cause severe diarrhea in patients with advanced human immunodeficiency virus (HIV) infection. Conflicting evidence exists as to whether Blastocystis hominis should also be included among the infectious agents capable of causing HIV-related dia
Intestinal T lymphocytes.: Scand J Gastroenterol Suppl. 1995;212:23-33. Unique Identifier : AIDSLINE MED/96117908; Robijn RJ; Logtenberg T; Wiegman LJ; van Berge Henegouwen GP; Houwen RW; Koningsberger JC; Dept. of Gastroenterology, Immunology, University Hospital; Utrecht, The Netherlands.; The intestine is largely colonized by bacteria and further exposed to an immense array of ingested and shed immunogenic material. Therefore, the gut associated lymphoid tissue plays a major role in the human immune system. It may even constitute a unique immune system of its own, since it has been demonstrated to diff
'The tropics in our bathroom': chronic diarrhoea after return from the tropics.: Scand J Gastroenterol Suppl. 1995;212:43-7. Unique Identifier : AIDSLINE MED/96117911; Overbosch D; Ledeboer M; Dept. of Tropical Medicine, Rode Kruis Ziekenhuis, Gravenhage,; The Netherlands.; Interest in imported tropical diseases has increased with the rising number of travellers to the tropics. This is especially true in the case of tropical gastroenterologic disorders. The causative organisms of chronic diarrhoea are different from those causing acute diarrhoea. Bacteria are relatively unusual; parasite
Voiding problems in patients with HIV infection and AIDS.: Scand J Urol Nephrol. 1995 Sep;29(3):295-8. Unique Identifier : AIDSLINE MED/96117958; Gyrtrup HJ; Kristiansen VB; Zachariae CO; Krogsgaard K; Colstrup H; Jensen KM; Department of Urology D, Rigshospitalet, University of; Copenhagen, Denmark.; The prevalence and type of urinary voiding problems were prospectively investigated in 77 men and four women (median age 36 years) with HIV infection or AIDS consecutively attending an outpatient clinic. Urologic symptoms were registered from replies to a questionnaire and urologic evaluation was made when indicated.
Leydig cell tumour in a man with human immunodeficiency virus.: Scand J Urol Nephrol. 1995 Sep;29(3):357-60. Unique Identifier : AIDSLINE MED/96117971; Sanchez-Chapado M; Angulo JC; Department of Urology, Hospital Principe de Asturias, Universidad; de Alcala de Henares, Madrid, Spain.; We report a case of Leydig-cell testicular tumour in a 32-year-old intravenous drug abuser bearing HIV-infection and pulmonary tuberculosis. The testicular mass was initially interpreted as genital tuberculosis and the diagnosis was made by aspiration cytology. Radical orchiectomy was performed and pathology revealed
Screening for fever in an adult emergency department: oral vs tympanic thermometry.: South Med J. 1996 Feb;89(2):230-4. Unique Identifier : AIDSLINE MED/96165414; Hooker EA; Houston H; Department of Emergency Medicine, University of Louisville School; of Medicine, Ky., USA.; The accuracy of tympanic thermometers in clinical practice continues to be questioned. We evaluated the Genius tympanic thermometer in our adult emergency department. All patients had both tympanic and oral temperature measurements. Patients with an oral or tympanic temperature > or = 100.0 degrees F had a rectal temp
The importance of social histories for assessing sexually transmitted disease risk.: Sex Transm Dis. 1995 Nov-Dec;22(6):348-50. Unique Identifier : AIDSLINE MED/96157998; Briggs LP; Patnaude P; Scavron J; Whelan M; Etkind P; Massachusetts Department of Public Health, Division of STD; Control, Jamaica Plain 02130, USA.; BACKGROUND: Although identifying risk groups for sexually transmitted diseases based on age or race may be useful for targeting screening efforts, clinicians should recognize that even members of most low-risk groups include some individuals at higher risk of infection. GOAL OF THIS STUDY: This case series of generall
The high prevalence of genital herpes among patients with genital ulcer disease in Uganda.: Sex Transm Dis. 1995 Nov-Dec;22(6):351-4. Unique Identifier : AIDSLINE MED/96157999; Kamya MR; Nsubuga P; Grant RM; Hellman N; Department of Medicine, School of Medicine, Makerere University,; Kampala, Uganda.; BACKGROUND: Genital ulcer disease is a risk factor for transmission of human immunodeficiency virus. One-hundred consecutive Ugandan patients (median age, 25 years) with genital ulcer disease were examined to determine the prevalence of genital herpes and its relationship to hum
Human immunodeficiency virus partner notification in a low incidence urban community.: Sex Transm Dis. 1995 Nov-Dec;22(6):377-9. Unique Identifier : AIDSLINE MED/96158003; Wells KD; Hoff GL; Health Department, Division of Communicable Disease Control,; Kansas City, MO 64109, USA.; BACKGROUND: Notification of the partners of a person newly diagnosed with human immunodeficiency virus (HIV) is legally mandated in Missouri. METHODS: In a four-year period, the Kansas City Health Department tested for HIV antibodies in 61,464 of 61,700 (99.6%) eligible persons using the sexually transmitted disease c
Acute gonococcal sepsis in an HIV-infected woman.: Sex Transm Dis. 1995 Nov-Dec;22(6):380-2. Unique Identifier : AIDSLINE MED/96158004; Jacoby HM; Mady BJ; Department of Internal Medicine, University of Rochester Medical; Center, New York, USA.; This is a case report of a 35-year-old woman infected with the human immunodeficiency virus who presented with acute bacterial sepsis that proved to be secondary to Neisseria gonorrhoeae. Typical skin and joint findings developed only after the acute sepsis had resolved. Patients with disseminated gonococcal infection
AIDS and hemophilia--current issues.: Thromb Haemost. 1995 Jul;74(1):36-9. Unique Identifier : AIDSLINE MED/96116761; Evatt BL; Centers for Disease Control and Prevention, Atlanta, Georgia; 30333, USA.
Effects of factor VIII concentrates on the immune system of patients with hemophilia.: Thromb Haemost. 1995 Jul;74(1):437-9. Unique Identifier : AIDSLINE MED/96116829; Mannucci PM; Angelo Bianchi Bonomi Hemophilia and Thrombosis Center,; University of Milan, Italy.; The introduction of high-purity factor VIII (FVIII) concentrates in the treatment of patients with hemophilia A has raised the issue that the use of these products may change on the immune system of the recipients. There is now clear evidence that high-purity concentrates, particularly those produced by immune-affinit
Immunohistologic studies on subpopulations of lymphocytes in cattle with enzootic bovine leukosis.: Vet Pathol. 1995 Sep;32(5):513-20. Unique Identifier : AIDSLINE MED/96090824; Chiba T; Hiraga M; Aida Y; Ajito T; Asahina M; Wu D; Ohshima K; Davis WC; Okada K; Department of Veterinary Pathology, Faculty of Agriculture, Iwate; University, Morioka, Japan.; The distribution of subpopulations of lymphocytes in lymph nodes and tumors from cattle with enzootic bovine leukosis (EBL) was examined by immunohistochemistry using a panel of monclonal antibodies against leukocyte differentiation molecules of EBL. The lesions in lymph nodes could be divided into three types based o
Experimental mucosal disease in cattle: changes of lymphocyte subpopulations in Peyer's patches and in lymphoid nodules of large intestine.: Vet Immunol Immunopathol. 1995 Oct;48(3-4):233-48. Unique Identifier : AIDSLINE MED/96131983; Liebler EM; Kusters C; Pohlenz JF; Department of Veterinary Pathology, Veterinary School Hannover,; Germany.; Changes in the number and distribution of lymphocyte subtypes were investigated in Peyer s patches in the jejunum and ileum, and mucosa-associated lymphoid nodules in the proximal colon and rectum of cattle with end-stage mucosal disease. Mucosal disease had been induced experimentally in seven of 13 animals by inocul
Study of HIV antibody screening for blood donors by a pooling-serum method [letter]: Vox Sang. 1995;69(3):255-6. Unique Identifier : AIDSLINE MED/96124558; Ji Y; Qu D; Jia G; Ren Q; Fang CT; Lam E; Ha BT; Dodd RY; Sullivan MT; Williams AE
Impact of immunosuppression caused by HIV infection on the replication of hepatitis C virus [letter]: Vox Sang. 1995;69(3):259-60. Unique Identifier : AIDSLINE MED/96124560; Soriano V; Bravo R; Mas A; Garcia-Samaniego J; Guierrez M; Gonzalez-Lahoz J
HTLV-I-associated illnesses in Spain. HTLV Spanish Study Group [letter]: Vox Sang. 1995;69(3):261-2. Unique Identifier : AIDSLINE MED/96124561; Soriano V; Gutierrez M; Vallejo A; Aguilera A; Calderon E; Escudero D
Recombinant gp160 vaccination schedule and MHC HLA type as factors influencing cellular responses to HIV-1 envelope glycoprotein. NIAID AIDS Vaccine Clinical Trials Network.: Vaccine. 1995 Sep;13(13):1170-9. Unique Identifier : AIDSLINE MED/96118124; Gorse GJ; Patel GB; Newman FK; Mandava M; Belshe RB; Division of Infectious Diseases, St. Louis University Health; Sciences Center, MO 63110-0250, USA.; This study assessed (1) T-cell responses following vaccination of HIV-1 negative volunteers with HIV-1LAI recombinant gp160 (rgp160) vaccine, and (2) effects of vaccine injection schedule and MHC HLA type on those responses. In one trial, volunteers received rgp160 in two accelerated schedules (Groups 1 and 2). In the
Antigenicity and immunogenicity of recombinant envelope glycoproteins of SIVmac32H with different in vivo passage histories.: Vaccine. 1995 Sep;13(13):1187-97. Unique Identifier : AIDSLINE GENBANK/L35597; Hulskotte EG; Rimmelzwaan GF; Boes J; Bosch ML; Heeney JL; Norley SG; de Vries P; Osterhaus AD; Laboratory of Vaccine Development and Immune Mechanisms, National; Institute of Public Health and Environmental Protection,; Bilthoven, The Netherlands.; Shortly after infection of two rhesus monkeys (Macaca mulatta) either with a SIVmac32H challenge stock or with the same virus that had been passaged in another rhesus monkey for 11 months, SIV-envelope genes were cloned from their peripheral blood mononuclear cells and subsequently expressed by recombinant vaccinia vi
A new epitope presenting system displays a HIV-1 V3 loop sequence and induces neutralizing antibodies.: Vaccine. 1995 Sep;13(13):1233-9. Unique Identifier : AIDSLINE MED/96118133; Scodeller EA; Tisminetzky SG; Porro F; Schiappacassi M; De Rossi A; Chiecco-Bianchi L; Baralle FE; International Centre for Genetic Engineering and Biotechnology,; Trieste, Italy.; The principal neutralizing domain, IGPGRAF sequence, from the V3-loop of HIV-1 was inserted in two positions on the surface of the protein that makes up the capside shell of the insect Flock House Virus. The hybrid proteins were expressed in insect cells via recombinant baculoviruses. Three different hybrids were used
Maintenance of high virus load even after seroconversion in newborn cats acutely infected with feline immunodeficiency virus.: Vaccine. 1995;13(15):1393-8. Unique Identifier : AIDSLINE MED/96145953; Tokunaga K; Shoda K; Nishino Y; Mori S; Zhong Q; Zheng YH; Kishi M; Ishihara C; Kanda M; Ikuta K; Section of Serology, Institute of Immunological Science, Hokkaido; University, Sapporo, Japan.; The viral loads in adult and newborn cats have been compared following injection with feline CD4+ FeL-039 line cells acutely infected with feline immunodeficiency virus (FIV). The level of virus genome in peripheral blood mononuclear cells (PBMC) increased progressively despite seroconversion in the newborn cats, wher
A multistep procedure for the chemical inactivation of human immunodeficiency virus for use as an experimental vaccine.: Vaccine. 1995 Nov;13(16):1567-75. Unique Identifier : AIDSLINE MED/96164473; Race E; Stein CA; Wigg MD; Baksh A; Addawe M; Frezza P; Oxford JS; Department of Academic Virology, London Hospital Medical College,; UK.; The kinetics of inactivation of four different strains of HIV-1 (RF, MN, SF2 and IIIB) by beta-propiolactone (BPL) and binary ethylenimine (BEI) were studied under various conditions. The conditions that would be required for the reduction of virus infectivity by at least 10(20) TCID50 ml-1 were estimated on the basis
Retroviral vector-transduced cells expressing the core polyprotein induce feline immunodeficiency virus-specific cytotoxic T-lymphocytes from infected cats.: Virus Res. 1995 Oct;38(2-3):93-109. Unique Identifier : AIDSLINE MED/96118168; Li J; Brown WC; Song W; Carpino MR; Wolf AM; Grant CK; Elder JH; Collisson EW; Department of Veterinary Pathobiology, Texas A&M University,; College Station 77843, USA.; The core polyprotein of feline immunodeficiency virus (FIV) was expressed in primary feline T-lymphocytes using a retroviral vector. These cells were used as antigen-presenting stimulator cells (APSC) for the in vitro induction of cytotoxic T-lymphocytes (CTL) from feline peripheral blood mononuclear cells (PBMC). CTL
[Virus-associated arthritis (see comments)]: Z Rheumatol. 1995 Nov-Dec;54(6):391-404. Unique Identifier : AIDSLINE MED/96143665; Saal JG; Malteserkrankenhaus St. Franziskushospital, Flensburg.; From the about 400 virus species known to cause illness in man, only a small but growing list of representatives are able to induce arthritis. Although virus-associated arthritides are mostly of acute and short-living type, some patients develop long-lasting or even chronic joint inflammation. The viral or host factor
Mucocutaneous fungal colonization in HIV-infected children.: Acta Derm Venereol. 1995 Jul;75(4):310-11. Unique Identifier : AIDSLINE MED/96112862; Don PC; Shen NN; Koestenblatt EK; Sierra MF; Stone RK; Bamji M; Department of Dermatology, New York Medical College-Metropolitan; Hospital Center, New York, USA.; The prevalence of symptomatic mucocutaneous candidiasis in HIV-infected children is well documented. Information, however, of the carriage rate of potential fungal pathogens is lacking. In this study we determined the fungal colonization rate of multiple mucocutaneous sites from 13 HIV-infected and 12 control children
Unusual course of the hepatitis C virus infection in one patient diagnosed of common variable immunodeficiency.: Allergol Immunopathol (Madr). 1995 Nov-Dec;23(6):263-6. Unique Identifier : AIDSLINE MED/96136350; Munoz FJ; de la Calle A; Gimenez MJ; Gonzalez J; Conde J; Servicio Regional de Alergologia e Inmunologia Clinica,; Hospital Universitario Virgen Macarena, Sevilla, Spain.; Common variable immunodeficiency (CV1) is defined by low serum IgG and IgA levels, and it is the second most frequent primary immunodeficiency. The indication for treatment with human gammaglobulin in patients with this syndrome has been well established. Here we report a case history of a patient diagnosed of common
Severe thrombocytopenia in patients treated with suramin: evidence for an immune mechanism in one.: Am J Hematol. 1996 Feb;51(2):152-7. Unique Identifier : AIDSLINE MED/96160435; Tisdale JF; Figg WD; Reed E; McCall NA; Alkins BR; Horne MK 3rd; Hematology Branch, National Lung and Blood Institute, National; Institutes of Health, Bethesda, MD 20892, USA.; Although suramin has long been used to treat human trypanosomiasis, recent clinical trials have tested its efficacy against the acquired immunodeficiency syndrome (AIDS) and various malignancies. Thromobocytopenia was observed in early trials with suramin in AIDS, but has been uncommon in patients treated for solid tu
AIDS-related pure red cell aplasia [letter]: Am J Hematol. 1996 Feb;51(2):171. Unique Identifier : AIDSLINE MED/96160440; Majluf-Cruz A; Luna-Castanos G; Nieto-Cisneros L
Short course dexamethasone for thrombocytopenia in AIDS.: Am J Med. 1996 Jan;100(1):117-8. Unique Identifier : AIDSLINE MED/96164820; Ramratnam B; Parameswaran J; Elliot B; Newstein M; Schiffman FJ; Rich JD; Flanigan TP; Miriam Hospital, Brown University School of Medicine, Providence,; Rhode Island, USA.
Adoptive transfer of experimental allergic encephalomyelitis after in vitro treatment with recombinant murine interleukin-12. Preferential expansion of interferon-gamma-producing cells and increased expression of macrophage-associated inducible nitric oxide synthase as immunomodulatory mechanisms.: Am J Pathol. 1996 Feb;148(2):375-82. Unique Identifier : AIDSLINE MED/96163272; Waldburger KE; Hastings RC; Schaub RG; Goldman SJ; Leonard JP; Department of Preclinical Research, Genetics Institute, Andover,; Massachusetts 01810, USA.; In an adoptive transfer model of experimental allergic encephalomyelitis, stimulation of lymph node cells with proteolipid protein and recombinant murine interleukin (rmIL)-12 before cell transfer accelerated the onset and exacerbates clinical disease. In vitro stimulation with proteolipid protein in the presence of r
Circulating human dendritic cells differentially express high levels of a 55-kd actin-bundling protein.: Am J Pathol. 1996 Feb;148(2):593-600. Unique Identifier : AIDSLINE MED/96163293; Mosialos G; Birkenbach M; Ayehunie S; Matsumura F; Pinkus GS; Kieff E; Langhoff E; Department of Microbiology and Molecular Genetics and Medicine,; Harvard Medical School, Boston, Massachusetts, USA.; This study was initiated to examine the differential expression of an evolutionary conserved human 55-kd actin-bundling (p55) protein that is induced in B lymphocytes by Epstein-Barr virus infection. Our study demonstrates that p55 is specifically expressed at constitutively high levels in human peripheral blood dendr
Otitis externa: management of the recalcitrant case.: Am J Otol. 1994 May;15(3):408-12. Unique Identifier : AIDSLINE MED/96148958; Selesnick SH; Department of Otolaryngology, Cornell University Medical; College--New York Hospital, NY 10021, USA.; Most cases of otitis externa respond to routine treatment, however, there is a subset of patients who frequently develop otitis externa that is usually severe and recalcitrant to routine therapy. These patients include the immunocompromised, those with AIDS, transplant recipients, severe diabetics, patients treated wi
[Molecular biology of infections caused by HIV and other hepatotropic viruses]: An R Acad Nac Med (Madr). 1995;112(3):585-613; discussion 614-5. Unique Identifier : AIDSLINE MED/96165981; Schuller Perez A
Sexual behaviour of male inmates of a detention facility in Singapore: risks of intraprison human immunodeficiency virus transmission.: Ann Acad Med Singapore. 1995 Sep;24(5):685-90. Unique Identifier : AIDSLINE MED/96161382; Lee JT; Adam Road Hospital, Singapore.; Sexual urges and needs do not cease merely upon the incarceration of an individual. They continue to exist in varying degrees in different individuals. This study looks into the sexual behaviour of all the male inmates of a detention facility in Singapore , both before and during
[Allogeneic transplantation and HIV infection: studies of HIV-infected tissue]: Laryngorhinootologie. 1995 Dec;74(12):761-4. Unique Identifier : AIDSLINE MED/96157858; Bujia J; Kastenbauer E; Wilmes E; Gurtler L; Klinik und Poliklinik fur Hals-Nasen- und Ohrenkranke.; BACKGROUND: Because of the limited availability of autologous tissue, stored allograft is commonly used. Before grafting, bank tissue is subjected to chemical preservation procedures. This procedure is important to diminish antigenicity and to inactivate possible inherent viruses. The aim of this study was to determin
[Infectious diseases from the hygienic viewpoint with special reference to environmental infections--a retrospective and prospective view]: Zentralbl Hyg Umweltmed. 1995 Apr;197(1-3):134-61. Unique Identifier : AIDSLINE MED/96158078; Exner M; Hygiene-Institut, Universitat Bonn.; Infectious diseases showed a considerable change in their epidemiologic significance during this century. Twenty years ago it seemed that infectious diseases would be definity under control. As a result there was a neglect of the efforts for prevention, recognition and controlling of infectious diseases, especially in
[Hygienic aspects with regard to nursing of home care patients with AIDS, chronic diseases and mental handicaps]: Zentralbl Hyg Umweltmed. 1995 Apr;197(1-3):26-44. Unique Identifier : AIDSLINE MED/96158073; Sonntag HG; Flassak H; Throm W; Abteilung Hygiene und Medizinische-Mikrobiologie; Hygiene-Institut, Universitat Heidelberg.; A human handicap is defined as a broad, hard and long lasting restriction of the mental development and the social integration. Groups of handicapped persons can be divided into mentally, psychologically, physically, sensory (blind, deaf) handicapped as well as into multiple disabled and chronically sick persons and t
Fas and FasL in the homeostatic regulation of immune responses.: Immunol Today. 1995 Dec;16(12):569-74. Unique Identifier : AIDSLINE MED/96114390; Lynch DH; Ramsdell F; Alderson MR; Immunex Corporation, Seattle, WA 98101, USA.; Studies of the biological effects of Fas signaling, using transformed cell lines as targets, indicate that ligation of the Fas receptor induces an apoptotic death signal. Chronically activated normal human T cells are also susceptible to Fas-mediated apoptosis. However, interactions between Fas and Fas ligand can also
Th1 and Th2: swinging to a hormonal rhythm [letter]: Immunol Today. 1995 Dec;16(12):605. Unique Identifier : AIDSLINE MED/96114396; Petrovsky N; Harrison LC
High resolution 2D-NMR studies indicating complete assignments and conformational characteristics of the NF-kappa B binding enhancer element of HIV-LTR.: J Biomol Struct Dyn. 1995 Oct;13(2):269-84. Unique Identifier : AIDSLINE MED/96127168; Singh MP; Fregeau NL; Pon RT; Lown JW; Department of Chemistry, University of Alberta, Edmonton, Canada.; The asymmetrical DNA duplex [5 d(AAGGGACTTTCC)].[5 -d(GGAAAGTCCCTT)] has been studied by one- and two-dimensional NMR techniques. The sequence is comprised of the actual 10 base-pair long binding site for the transcription factor NF-kappa B in the enhancer sequence of the long term repeat (LTR) region of HIV and SIV t
Myopathy and HIV infection.: Curr Opin Rheumatol. 1995 Nov;7(6):497-502. Unique Identifier : AIDSLINE MED/96163713; Chariot P; Gherardi R; Groupe de Recherche en Pathologie Neuromusculaire, Hopital Henri; Mondor, Creteil, France.; Skeletal muscle involvement may occur at all stages of HIV infection. The most simple classification of muscular disorders in HIV-infected patients is 1) HIV-associated myopathies, 2) zidovudine myopathy, 3) HIV wasting syndrome, and 4) opportunistic infections and tumoral infiltrations of muscle. Immunohistology for
Overlapping syndromes, undifferentiated connective tissue disease, and other fibrosing conditions.: Curr Opin Rheumatol. 1995 Nov;7(6):568-73. Unique Identifier : AIDSLINE MED/96163724; Kallenberg CG; University Hospital Groningen, Department of Clinical Immunology,; The Netherlands.; Connective tissue diseases (CTDs) frequently present with one or only a few symptoms, which does not allow prompt diagnosis. Raynaud s phenomenon is one of those symptoms. However, only a minority of patients who present with Raynaud s phenomenon develop a CTD. Prognostic factors for the future development of CTD in s
IL-4 producing CD4+ TCR alpha beta int liver lymphocytes: influence of thymus, beta 2-microglobulin and NK1.1 expression.: Int Immunol. 1995 Nov;7(11):1729-39. Unique Identifier : AIDSLINE MED/96162431; Emoto M; Emoto Y; Kaufmann SH; Department of Immunology, University of Ulm, Germany.; The present report describes developmental, phenotypic and functional features of unconventional CD4+ TCR alpha beta lymphocytes. In C57BL/6 mice, the majority of liver lymphocytes expressing intermediate intensity of TCR alpha beta (TCR alpha beta int) are CD4+ NK1.1+ and express a highly restricted TCR V beta repert
Presentation of peptides by cultured monocytes or activated T cells allows specific priming of human cytotoxic T lymphocytes in vitro.: Int Immunol. 1995 Nov;7(11):1741-52. Unique Identifier : AIDSLINE MED/96162432; Gagliardi MC; De Petrillo G; Salemi S; Boffa L; Longobardi MG; Dellabona P; Casorati G; Tanigaki N; Harris R; Lanzavecchia A; et al; Istituto I Clinica Medica, Universita di Roma La Sapienza,; Italy.; The conditions favouring effective specific cytotoxic T lymphocyte (CTL) priming have been exploited to set up a simple and reproducible method to induce a primary CTL response in vitro. We report that cultured monocytes, as well as activated T cells, pulsed with exogenous HLA-A2 binding immunogenic peptides, can indu
CD44 plays a co-stimulatory role in murine T cell activation: ligation of CD44 selectively co-stimulates IL-2 production, but not proliferation in TCR-stimulated murine Th1 cells.: Int Immunol. 1995 Nov;7(11):1779-86. Unique Identifier : AIDSLINE MED/96162436; Sommer F; Huber M; Rollinghoff M; Lohoff M; Institute of Clinical Microbiology, University of; Erlangen-Nurnberg, Germany.; The murine CD44 receptor family is thought to be involved in a variety of lymphocyte functions, including lymphopoesis, lymphocyte homing and cell migration. Herein, we show that murine CD44 also plays a role as a co-stimulatory molecule for the activation of CD4+ T cells. Ligation of CD44 by mAb enhanced
The protein tyrosine kinase Fyn activates transcription from the HIV promoter via activation of NF kappa B-like DNA-binding proteins.: Int Immunol. 1995 Nov;7(11):1851-9. Unique Identifier : AIDSLINE MED/96162443; Hohashi N; Hayashi T; Fusaki N; Takeuchi M; Higurashi M; Okamoto T; Semba K; Yamamoto T; Department of Oncology, University of Tokyo, Japan.; Protein tyrosine kinase p59fyn (Fyn) associates with the TCR-CD3 complex, which suggests that Fyn plays a significant role in the signal transduction involving TCR complex. In addition to cellular genes, viral promoters such as the HIV long terminal repeat (LTR) are also activated upon T cell activation. To elucidate
Migration pathways of CD4 T cell subsets in vivo: the CD45RC- subset enters the thymus via alpha 4 integrin-VCAM-1 interaction.: Int Immunol. 1995 Nov;7(11):1861-71. Unique Identifier : AIDSLINE MED/96162444; Bell EB; Sparshott SM; Ager A; Immunology Research Group, University of Manchester, UK.; The present investigation examines the localization and migration of purified T cell subsets in comparison with B cells, CD8 T cells and CD4+ CD8- single-positive thymocytes. CD4 T cell subsets in the rat are defined by mAb MRC OX22 (anti-CD45RC), which distinguishes resting CD4 T cells (CD45RC+) from those (CD45RC-)
In vitro antiviral activities of sulfated polysaccharides from a marine microalga (Cochlodinium polykrikoides) against human immunodeficiency virus and other enveloped viruses.: Int J Biol Macromol. 1995 Oct;17(5):293-7. Unique Identifier : AIDSLINE MED/96121688; Hasui M; Matsuda M; Okutani K; Shigeta S; Faculty of Agriculture, Kagawa University, Japan.; A marine microalga, Cochlodinium polykrikoides, produces extracellular sulfated polysaccharides. Isolation and purification of the polysaccharides were accomplished by precipitation with ethanol and Cetavlon, followed by DEAE-cellulose column chromatography (polysaccharides A1 and A2). These polysaccharides, which wer
[Diagnostic results of abdominal computerized tomography in HIV-infected patients]: Aktuelle Radiol. 1995 Nov;5(6):351-5. Unique Identifier : AIDSLINE MED/96149787; Knollmann FD; Grunewald T; Maurer J; Schedel H; Schroder R; Pegios W; Vogl TJ; Pohle HD; Felix R; Strahlenklinik und Poliklinik, Freie Universitat Berlin,; Klinikum Rudolf Virchow.; The exact frequency of pathologic findings in abdominal computed tomograms of HIV-infected patients is not yet known. To analyse such findings, CT scans of 339 HIV-infected patients were reviewed. While over four fifths of patients displayed abnormal findings; hepatosplenomegaly, lymphadenopathy, pathologically enlarg
Genome analysis of North American small ruminant lentiviruses by polymerase chain reaction and restriction enzyme analysis.: J Vet Diagn Invest. 1995 Oct;7(4):437-43. Unique Identifier : AIDSLINE MED/96155806; Rosati S; Kwang J; Keen JE; Department of Animal Production, Epidemiology and Ecology,; University of Turin, Italy.; The polymerase chain reaction (PCR) was used to amplify portions of the gag and env structural genes of 8 ovine and 1 caprine lentivirus isolates of North American origin. Three sets of primers were used to amplify p16, p25, and N -gp40 gene fragments, and 1 set, annealing highly conserved portions of long terminal re
Prospective study of fluconazole suspension for the treatment of oesophageal candidiasis in patients with AIDS.: Aliment Pharmacol Ther. 1995 Oct;9(5):553-6. Unique Identifier : AIDSLINE MED/96126225; Laine L; Rabeneck L; University of Southern California School of Medicine, Los Angeles; 90033, USA.; BACKGROUND: Oesophageal candidiasis is the most common cause of oesophageal symptoms in patients with AIDS. Antifungal therapy, given as a suspension, may be better tolerated than capsules or tablets in children or patients with oesophageal symptoms. We performed a prospective study of the safety and efficacy of fluco
Proinflammatory cytokine expression in cervicovaginal secretions of normal and HIV-infected women.: Cytokine. 1995 Aug;7(6):568-74. Unique Identifier : AIDSLINE MED/96100024; Belec L; Gherardi R; Payan C; Prazuck T; Malkin JE; Tevi-Benissan C; Pillot J; Unite d'Immunologie Microbienne, Institut Pasteur, Paris,; France.; Proinflammatory cytokines may stimulate replication and spread of HIV. To evaluate to what extent the female genital tract represents a source of these cytokines, we determined TNF-alpha, IL-1 beta and IL-6 concentrations in paired serum and cervicovaginal washings from 45 HIV-negative and 50 HIV-positive women, and t
[Strongyloides stercoralis hyperinfection syndrome in a patient with human immunodeficiency virus (HIV) infection: report of a case and review of the literature]: Rev Gastroenterol Peru. 1995 Sep-Dec;15(3):290-5. Unique Identifier : AIDSLINE MED/96151769; Del Carpio D; Rodriguez D; Vildosola H; Departamento de Medicina, Hospital Arzobispo Loayza.; A case of a twenty-one year old woman with Strongyloides stercoralis hyperinfection associated with human immunodeficiency virus infection that represents the fifteen case reported in the literature is here presented. Hypothesis for which this association is infrequent and several therapeutic alternatives are reviewed
At risk, infected, and invisible: older gay men and HIV/AIDS.: J Assoc Nurses AIDS Care. 1995 Nov-Dec;6(6):13-9. Unique Identifier : AIDSLINE MED/96164088; Grossman AH; Department of Health Studies, School of Education, New York; University, New York, USA.; Older gay men over the age of 50 have been and continue to be an invisible part of the HIV/AIDS epidemic. The reasons for this phenomenon are many, but among them are societal beliefs, myths, and stereotypes emanating from ageism and homophobia. In addition, HIV/AIDS is sometimes misdiagnosed in older adults because m
Healthcare needs of HIV-infected persons in hospital, outpatient, home, and long-term care settings.: J Assoc Nurses AIDS Care. 1995 Nov-Dec;6(6):21-33. Unique Identifier : AIDSLINE MED/96164089; Baigis-Smith J; Gordon D; McGuire DB; Nanda J; Georgetown University School of Nursing, Washington, DC, USA.; In this descriptive study, healthcare needs reported by 386 HIV-infected persons from all risk categories and their primary nurses from four care settings (hospital, outpatient, long-term care, and home) are identified. Healthcare needs were classified into four domains of nursing practice using a conceptual framework
AIDS nursing care and standardized nursing language: an application of the nursing intervention classification.: J Assoc Nurses AIDS Care. 1995 Nov-Dec;6(6):37-44. Unique Identifier : AIDSLINE MED/96164090; Davis KA; University of Iowa Hospitals and Clinics, Iowa City, USA.; Standardized nursing language is recommended increasingly as a method to describe the work of nursing, adapt to computerized documentation, and establish a place for nursing in national data bases. Nursing diagnosis has become a standard label for assessment data. The Iowa Interventions Project Research Team proposes
Health-illness beliefs and practices of Haitians with HIV disease living in Boston.: J Assoc Nurses AIDS Care. 1995 Nov-Dec;6(6):45-53. Unique Identifier : AIDSLINE MED/96164091; Martin MA; Rissmiller P; Beal JA; Diabetes Program, Boston City Hospital, MA, USA.; The authors of this qualitative study explored the health-illness beliefs and practices of Haitians with HIV disease. The authors obtained a purposive sample of five Haitian men and four Haitian women with symptomatic HIV disease or AIDS living in Boston. Five themes were identified through content analysis of intervi
Perceived barriers to getting published: results of the JANAC survey.: J Assoc Nurses AIDS Care. 1995 Nov-Dec;6(6):57-62. Unique Identifier : AIDSLINE MED/96164092; Meisenhelder JB; Kalinoski J; Saunders JM; MGH Institute of Health Professions, Boston, MA, USA.; In order to identify strategies to promote the publication of ANAC members knowledge and expertise, the authors conducted a survey of JANAC readers. Twenty-four respondents, almost all clinicians, identified 25 areas of interest they want to develop for publication. Barriers to getting published fell into four catego
Characterization of distribution of T lymphocyte subsets and activated T lymphocytes infiltrating into sarcoid lesions [see comments]: Intern Med. 1995 Sep;34(9):847-55. Unique Identifier : AIDSLINE MED/96121647; Kita S; Tsuda T; Sugisaki K; Miyazaki E; Matsumoto T; Third Department of Internal Medicine, Oita Medical University.; We studied the relationship between various T lymphocyte functions and granuloma formation in 5 lung tissue and 4 lymph node tissue samples from patients with sarcoidosis by immunohistological methods. In the lesion of sarcoidosis, T cells were positive for alpha beta TCR, but gamma delta TCR-positive T cells were rar
[Cooperation in public health in the Bodensee district from the viewpoint of Vorarlberg]: Gesundheitswesen. 1995 Nov;57(11):718-21. Unique Identifier : AIDSLINE MED/96147352; Bechter E; Amt der Vorarlberger Landesregierung, Sanitatsabteilung.; Following a brief presentation of a few significant data and specifications in respect of the structure and organisation of the Austrian Public Health administration, general basic rules for across-the-border cooperation in the region of Lake Constance are outlined. The following subjects for such cooperation are list
[What physicians should currently observe in the area of dental health]: Gesundheitswesen. 1995 Nov;57(11):741-3. Unique Identifier : AIDSLINE MED/96147358; Buttner M; Several factors govern the development of human dental caries. The actual caries incidence in children depends greatly on fluoride consumption, reduction of fermentable sugar intake (in favour of the use of sugar substitutes), dental health habits and regular dental check-ups. A significant reduction of dental caries
[Reappearance of tuberculosis, risks and consequences!]: Gesundheitswesen. 1995 Dec;57(12):798-805. Unique Identifier : AIDSLINE MED/96156883; Exner-Freisfeld H; Johann-Wolfgang-Goethe-Universitat, Zentrum der Inneren Medizin,; Infektiologie, Frankfurt/Main.; WHO estimates that worldwide cases of TB will amount to 8.8 million in 1995 and 11.9 million in 2005. Compared with the estimated amount of TB cases of 7.5 million in 1990 there is a rise by 16.3 percent for 1995 and by 57.6 per cent for 2005. Treatment costs for TB are relatively low. If properly administered the tre
[Effects of Shenmai injection on immune function in stomach cancer patients after chemotherapy]: Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1995 Aug;15(8):451-3. Unique Identifier : AIDSLINE MED/96147895; Lin SY; Liu LM; Wu LC; Zhejiang provincial Hospital of TCM, Hangzhou.; Sixty-three cases with stomach cancer were randomized and observed, the results showed that the count of T lymphocytes in chemotherapy combined with Shenmai injection (SMI) group increased, while in control group it decreased, the difference was significant (P
[Effect of Jinshuibao capsule on the immunological function of 36 patients with advanced cancer]: Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1995 Aug;15(8):476-8. Unique Identifier : AIDSLINE MED/96147902; Zhou DH; Lin LZ; First Affiliated Hospital, Guangzhou University of TCM.; Jinshuibao Capsule (JSBC), produced by Jiangxi Jinshuibao pharmaceutical Company Limited, possesses the similar active principles and pharmacological activity with those of Cordyceps sinensis. The effect of JSBC on the immunological function of 36 patients with advanced cancer showed that it could restore cellular imm
HIV interactions with cells of the nervous system.: Curr Opin Neurobiol. 1995 Oct;5(5):647-55. Unique Identifier : AIDSLINE MED/96163703; Dubois-Dalcq M; Altmeyer R; Chiron M; Wilt S; Departement de Virologie, Institut Pasteur, Paris, France.; mdalcq@pasteur.fr; HIV can invade the CNS, where it replicates principally in macrophages. Yet, neurological disease is more often correlated with levels of neurotoxins or tumor necrosis factor alpha than with viral replication or specific viral determinants in brain. In experimental systems, HIV glycoprotein affects functions of uninfe
Immunologic type of thyroid lymphoma in an adult T-cell leukemia endemic area in Japan.: Leuk Lymphoma. 1995 Apr;17(3-4):341-4. Unique Identifier : AIDSLINE MED/96172088; Ohsawa M; Noguchi S; Aozasa K; Department of Pathology, Osaka University School of Medicine,; Suita, Japan.; Our previous study showed that thyroid non-Hodgkin s lymphoma (TL) in an adult T-cell leukemia/lymphoma (ATL) non-endemic area were exclusively B-cell derived. The present study was carried out to examine whether TL in an ATL endemic area are also exclusively of B-cell type. Eight
Deficient antipneumococcal polysaccharide responses in HIV-seropositive patients.: FEMS Immunol Med Microbiol. 1995 Sep;12(1):33-41. Unique Identifier : AIDSLINE MED/96128450; Loeliger AE; Rijkers GT; Aerts P; Been-Tiktak A; Hoepelman AI; van Dijk H; Borleffs JC; University Hospital Utrecht, Department of Internal Medicine, The; Netherlands.; In a prospective study, serological responses and opsonic activity towards Streptococcus pneumoniae were measured in 60 HIV-infected patients and 25 controls after the administration of the 23-valent pneumococcal vaccine (PneumovaxR). Serum samples were collected before vaccination and at weeks 1, 2, 4, and 12 after v
The incidence and prevalence of AIDS and prevalence of other severe HIV disease in England and Wales for 1995 to 1999: projections using data to the end of 1994.: Commun Dis Rep CDR Rev. 1996 Jan 5;6(1):R1-21. Unique Identifier : AIDSLINE MED/96166069; Projections of the future incidence of AIDS cases are needed for planning purposes, to help set research priorities, and to describe the most likely pattern of transmission of HIV infection in the past that underlies the observed and projected incidence of AIDS. Earlier reports of projections for England and Wales wer
Unlinked anonymous monitoring of HIV prevalence in England and Wales: data to the end of 1994.: Commun Dis Rep CDR Wkly. 1995 Dec 29;5(52):299-301. Unique Identifier : AIDSLINE MED/96166070
Isolation of anti-HIV-1 lignans from Larrea tridentata by counter-current chromatography.: J Chromatogr A. 1996 Jan 8;719(2):353-64. Unique Identifier : AIDSLINE MED/96155178; Gnabre JN; Ito Y; Ma Y; Huang RC; Department of Biology, Johns Hopkins University, Baltimore, MD; 21218-2685, USA.; Several lignans, mostly new, were isolated from Larrea tridentata by assay-guided counter-current chromatography (CCC). Using the secreted alkaline phosphatase bioassay of HIV Tat transactivation and the two-phase hexane-ethyl acetate-methanol-water solvent system, two major components (Gr and Lo) were identified as a
[HIV seropositivity in blood donations: prevalence, residual risk and epidemiology. The Retrovirus Work Group of the French Society of Blood Transfusion]: Transfus Clin Biol. 1995;2(5):357-63. Unique Identifier : AIDSLINE MED/96151338; Courouce AM; Institut National de la Transfusion Sanguine, Paris.; As it has been observed since the beginning of anti-HIV screening in blood donations, the rate of seropositive donations has been still decreasing during these 4 last years: 0.090/1000 in 1991 to 0.042/1000 in 1994. This decrease has been observed in blood donations from first-time donors (0.38 to 0.17/1000) and from
[Reevaluation of the sensitivity of screening assays for anti-HIV antibodies. The Retrovirus Work Group of the SFTS. French Society of Blood Transfusion]: Transfus Clin Biol. 1995;2(5):395-408. Unique Identifier : AIDSLINE MED/96151343; Courouce AM; Institut National de la Transfusion Sanguine, Paris.; A comparative evaluation of the sensitivity of anti-HIV screening assays has been recently performed with a selected panel including all the actually known difficulties of HIV serology: Very recent seroconversions (per-seroconversions) and recent HIV1/M seroconversions, HIV1/M seropositive with a subtype different fro
A humanized, bispecific immunoadhesin-antibody that retargets CD3+ effectors to kill HIV-1-infected cells.: J Hematother. 1995 Oct;4(5):439-46. Unique Identifier : AIDSLINE MED/96129480; Chamow SM; Zhang D; Tan XY; Mhatre SM; Marsters SA; Peers DH; Byrn RA; Ashkenazi A; Junghans RP; Department of Recovery Sciences, Genentech, Inc., S. San; Francisco, CA 94080, USA.; We have developed a humanized, bispecific immunoadhesin-antibody (BsIAb) that targets and kills HIV-infected cells. Comprised of CD4-IgG and humanized anti-CD3-IgG, this BsIAb is bifunctional. First, in targeting, it exploits the natural affinity of CD4 for gp120 to target the BsIAb to HIV-infected cells, and second,
An alternate synthesis of the Tat-antagonist 7-chloro-N-methyl-5-(1H-pyrrol-2-yl)-3H-1,4-benzodiazepin-2-amine- .: Bioorg Med Chem. 1995 Apr;3(4):391-5. Unique Identifier : AIDSLINE MED/96172304; Maehr H; Zenchoff G; Coffen DL; Roche Research Center, Hoffmann La Roche Inc., Nutley, NJ 07110,; USA.; An alternative synthesis of 7-chloro-N-methyl-5-(1H-pyrrol-2-yl)-3H-1,4-benzodiazepin-2-amine- , the compound that inhibits gene expression by HIV-1 at the level of transcriptional transactivation by Tat, has been developed. The process is based on ring expansion of 6-chloro-2-chloromethyl-4-(1H-pyrrol-2-yl)quinazolin
Synthesis and conformational analysis of pyrimidine nucleoside analogues with a rigid sugar moiety.: Bioorg Med Chem. 1995 Apr;3(4):397-402. Unique Identifier : AIDSLINE MED/96172305; Bjorsne M; Szabo T; Samuelsson B; Classon B; Department of Organic Chemistry, Stockholm University, Sweden.; In order to obtain rigidity within the sugar moiety of nucleosides, some bicyclic pyrimidine nucleoside analogues were synthesized starting from cyclopentanone. The C-3 is fused to C-4 via a propylene linker in order to obtain a [3.3.0]-bicyclic ring system wherein the sugar moiety should be restricted to mainly the
2-amino-9-(3-azido-2,3-dideoxy-beta-D-erythro-pentofuranosyl)-6-s- ubstituted-9H-purines: synthesis and anti-HIV activity.: Bioorg Med Chem. 1995 Apr;3(4):447-58. Unique Identifier : AIDSLINE MED/96172310; Freeman GA; Shaver SR; Rideout JL; Short SA; Burroughs Wellcome Co., Division of Organic Chemistry, Research; Triangle Park, NC 27709, USA.; A series of 2-amino-9-(3-azido-2,3-dideoxy-beta-D-erythro-pentofuranosyl)-6- substituted-9H-purines was synthesized and tested for the ability to protect MT4 cells from the cytopathic effect of HIV-1IIIB. These compounds were prepared by a combination of chemical and enzymatic reactions. Some of the nucleoside analogs
[Relationship between AIDS and atopy (editorial)]: Rev Alerg Mex. 1995 Nov-Dec;42(6):96-7. Unique Identifier : AIDSLINE MED/96151756; Hernandez Bautista VM; Flores Sandoval G; Gomez Vera J; Orea Solano M
Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase.: Neurodegeneration. 1995 Sep;4(3):315-21. Unique Identifier : AIDSLINE MED/96130874; Corasaniti MT; Melino G; Navarra M; Garaci E; Finazzi-Agro A; Nistico G; Faculty of Pharmacy, University of Reggio Calabria, Cantanzaro,; Italy.; The cytotoxic effects of the human immunodeficiency virus type 1 (HIV-1) coat protein gp120 were studied in human CHP100 neuroblastoma cell cultures. Incubation of neuroblastoma cultures with gp120 (1 pM-10 nM) induces cell death which is not concentration-related. The significant cell death evoked by 10 pM gp120 was
[HIV (human immunodeficiency virus) disease and AIDS (acquired immunodeficiency syndrome)]: Ryoikibetsu Shokogun Shirizu. 1995;(8):255-7. Unique Identifier : AIDSLINE MED/96165851; Fujii T; Fujimura K; Takata N; Kuramoto A; Department of Hematology and Oncology, Hiroshima University.
Rev protein suppression of complex formation between nuclear proteins and rev-responsive element-containing RNA of human immunodeficiency virus-1.: Int J Biochem Cell Biol. 1995 Dec;27(12):1317-29. Unique Identifier : AIDSLINE MED/96116531; Bek A; Muller WE; Seve AP; Kavsan V; Schroder HC; Institut fur Physiologische Chemie, Universitat, Mainz,; Germany.
Selective restimulation of antigen or allergen preactivated T cells using OKT3 F(ab)2 results in the secretion of TH-1 or TH-2-like cytokine patterns.: Clin Exp Allergy. 1995 Nov;25(11):1108-17. Unique Identifier : AIDSLINE MED/96161002; Jutel M; Wyss-Coray T; Carballido JM; Blaser K; Muller UR; Pichler WJ; Zieglerspital, Bern, Switzerland.; BACKGROUND: The synthesis of IgE is regulated by cytokines secreted from T-helper cells. The studies on cytokine secretion by peripheral blood mononuclear cells (PBMC) upon stimulation with antigen or allergen are difficult due to low levels of cytokines, especially of interleukin-4 (IL-4). OBJECTIVE: In this study we
Lymphocyte traffic through lymph nodes and Peyer's patches of the rat: B- and T-cell-specific migration patterns within the tissue, and their dependence on splenic tissue.: Cell Tissue Res. 1995 Dec;282(3):377-86. Unique Identifier : AIDSLINE MED/96065187; Blaschke V; Micheel B; Pabst R; Westermann J; Zentrum Anatomie 4120, Medizinische Hochschule Hannover, D-30623; Hannover, Germany.; The migration routes of lymphocyte subsets through organ compartments are of importance when trying to understand the local events taking place during immune responses. We have therefore studied the traffic of B, T, CD4(+), and CD8(+ )lymphocytes through lymph nodes and Peyer s patches. At various time points after in
Bronchoalveolar lavage for the diagnosis of disseminated toxoplasmosis in AIDS patients.: Diagn Microbiol Infect Dis. 1995 Aug;22(4):339-41. Unique Identifier : AIDSLINE MED/96157445; Gadea I; Cuenca M; Benito N; Pereda JM; Soriano F; Department of Medical Microbiology, Fundacion Jimenez Diaz,; Madrid, Spain.; The usefulness of cell culture of bronchoalveolar lavage fluid for the diagnosis of toxoplasmosis in immunocompromised hosts has not been stressed previously. We report an acquired immunodeficiency syndrome patient with disseminated toxoplasmosis who was diagnosed by isolation of Toxoplasma gondii in cell cultures fro
Flow cytometric detection of human immunodeficiency virus type 1 proviral DNA by the polymerase chain reaction incorporating digoxigenin- or fluorescein-labeled dUTP.: Cytometry. 1995 Oct 1;21(2):197-202. Unique Identifier : AIDSLINE MED/96120901; Yang G; Olson JC; Pu R; Vyas GN; Department of Laboratory Medicine, University of California, San; Francisco 94143, USA.; Serological assays are routinely used in the laboratory diagnosis of human immunodeficiency virus type-1 (HIV-1) infection, but the polymerase chain reaction (PCR) is ultimately the most sensitive and direct method for establishing definitive diagnosis. As an alternative to the conventional radioactive PCR procedure w
Rhodamine 123: a useful probe for monitoring T cell activation.: Cytometry. 1995 Nov 1;21(3):284-93. Unique Identifier : AIDSLINE MED/96139620; Ferlini C; Biselli R; Nisini R; Fattorossi A; Laboratory of Immunology, D.A.S.R.S., Pomezia, Rome.; The T cell activation pathway involves an increase in mitochondrial activity. This can be evaluated in individual cells using the fluorescent probe rhodamine 123 (Rh123) and flow cytometry. Peripheral blood mononuclear cells (PBMC) were stimulated with optimal concentrations of phytohaemagglutinin (PHA), superantigens
Clastogenic factors in plasma of HIV-1 infected patients.: Free Radic Biol Med. 1995 Dec;19(6):843-8. Unique Identifier : AIDSLINE MED/96128480; Fuchs J; Emerit I; Levy A; Cernajvski L; Schofer H; Milbradt R; Department of Dermatology, Frankfurt University Hospital,; Germany.; The objective of this study was to investigate the clastogenic activity of plasma ultrafiltrates from HIV-1 infected patients. Clastogenic factors are chromosome-damaging agents with low molecular weight (
[Nucleic acid vaccines for study in AIDS patients are approved. Vaccines of genetic molecules--humoral and cellular immune response (news)]: Fortschr Med. 1995 Dec 20;113(35-36):12. Unique Identifier : AIDSLINE MED/96156871; Hobom B
[Controversy over tuberculosis therapy in HIV infected patients. Isoniazide therapy--brief chemotherapy (news)]: Fortschr Med. 1995 Dec 20;113(35-36):14-5. Unique Identifier : AIDSLINE MED/96156872; Arnheim K
[Urban & Vogel Workshop. Atrial fibrillation--decision aids for ambulatory therapy]: Herz. 1995 Dec;20 Suppl 3:1-16. Unique Identifier : AIDSLINE MED/96139239
[Bovine protein kinase C isotypes transduced into Molt-4/HIV-1 cells augment the expression of HIV-1 genome]: Hokkaido Igaku Zasshi. 1995 Nov;70(6):861-83. Unique Identifier : AIDSLINE MED/96143485; Izumi T; Department of Microbiology, Hokkaido University School of; Medicine, Sapporo, Japan.; Protein kinase C (PKC) is known to be an ubiquitous enzyme found in a variety of mammalian tissue and has been shown to require Ca2+ and phospholipid, and to be further activated by diacylglycerol, which increased the affinity of the kinase for both Ca2+ and phospholipid. PKC is composed with a family of multiple isot
Immunologic studies in children with idiopathic short stature before and during growth hormone therapy. Dutch Growth Hormone Working Group.: Horm Res. 1995;44(5):203-7. Unique Identifier : AIDSLINE MED/96159558; Rekers-Mombarg LT; Rijkers GT; Massa GG; Wit JM; Department of Paediatrics, University Hospital Leiden, The; Netherlands.; In 34 children with idiopathic short stature (ISS) we studied parameters of humoral and cellular immunity before and during growth hormone (GH) therapy. The patients were treated with recombinant human GH 3.0 or 4.5 IU/m2 body surface/day, 6 times/week. Leucocyte and lymphocyte counts, percentages of neutrophils, eosi
Benefit of oral zinc supplementation as an adjunct to zidovudine (AZT) therapy against opportunistic infections in AIDS.: Int J Immunopharmacol. 1995 Sep;17(9):719-27. Unique Identifier : AIDSLINE MED/96153666; Mocchegiani E; Veccia S; Ancarani F; Scalise G; Fabris N; Gerontology Research Department, Italian National Research; Centres on Ageing (INRCA), Ancona, Italy.; Zinc is perhaps the most important trace element for immune function. Congenital or acquired zinc deficiencies are associated with immune abnormalities and increased susceptibility to infectious diseases. AIDS subjects suffer from reduced zinc bioavailability, more severe in stage IV than in stage III. Such zinc defic
Dose-dependent opposite effect of zinc on apoptosis in mouse thymocytes.: Int J Immunopharmacol. 1995 Sep;17(9):735-44. Unique Identifier : AIDSLINE MED/96153668; Provinciali M; Di Stefano G; Fabris N; Gerontology Research Department, Italian National Research; Centres on Aging (INRCA), Ancona, Italy.; Zinc is a crucial nutritional component required for the normal development and maintenance of immune functions. It has been reported that zinc is a potent inhibitor of DNA fragmentation, the specific marker of apoptosis. The effect of zinc on apoptotic cell death has been previously studied in a narrow range of high
Methyl inosine monophosphate (MIMP) augments T-lymphocyte mitogen responses and reverses various immunosuppressants.: Int J Immunopharmacol. 1995 Sep;17(9):763-70. Unique Identifier : AIDSLINE MED/96153671; Hadden EM; Wang Y; Sosa M; Coffey RG; Giner-Sorolla A; Hadden JW; Immunopharmacology Division, University of South Florida Medical; College, Tampa 33612, USA.; Methyl inosine monophosphate (MIMP) augments preferentially the in vitro responses of human and murine lymphocytes to a T-cell mitogen such as phytohemagglutinin (PHA) and inconsistently to a B-cell mitogen such as pokeweed or lipopolysaccharide (LPS). In a normal interleukin-2-dependent cell line (CTLL), MIMP showed
[Leprosy and vaccine]: Nippon Rai Gakkai Zasshi. 1995 Nov;64(3):163-73. Unique Identifier : AIDSLINE MED/96143964; Matsumoto S; Yamada T; Department of Oral Microbiology, Nagasaki University School of; Dentistry, Japan.
A new HIV/AIDS drug.: J Ark Med Soc. 1996 Jan;92(8):407. Unique Identifier : AIDSLINE MED/96166184
Immunosuppressive mechanisms in semen: implications for contraception.: Hum Reprod. 1995 Jul;10(7):1686-93. Unique Identifier : AIDSLINE MED/96033129; Kelly RW; Medical Research Council Reproductive Biology Unit, University of; Edinburgh Centre for Reproductive Biology, UK.; The immunosuppressive effects of human seminal plasma are mediated by several factors. The prostaglandins (PG) of the E series (PGE and 19-hydroxy PGE) predominate and raise intracellular cAMP in leukocytes. By this mechanism they suppress lymphocyte proliferation, natural killer (NK) cell activity and are likely to m
Assessing the health behaviors of Texas college students.: J Am Coll Health. 1996 Jan;44(4):167-72. Unique Identifier : AIDSLINE MED/96166138; Wiley DC; James G; Jordan-Belver C; Furney S; Calsbeek F; Benjamin J; Kathcart T; Southwest Texas State University, San Marcos, USA.; The authors of this study examined the health behaviors of Texas college students, using a telephone survey to assess 1,408 randomly selected students enrolled in 23 institutions of higher education. Eighty-nine percent of those surveyed had consumed alcohol at least once, and nearly one third considered themselves re
AIDS-associated intussusception in young adults.: J Clin Gastroenterol. 1995 Sep;21(2):158-62. Unique Identifier : AIDSLINE MED/96064188; Wood BJ; Kumar PN; Cooper C; Silverman PM; Zeman RK; Department of Radiology, Georgetown University Medical Center,; Washington, D.C. 20007, USA.; We have examined the changing demographics of adult intussusception and implicate human immunodeficiency virus (HIV)- and acquired immune deficiency syndrome (AIDS)-associated gastrointestinal pathology as risk factors for intussusception in young adults. The clinical index of suspicion for intussusception should be r
Primary gastric T-cell lymphoma with cutaneous involvement. A case report and review of the literature.: J Clin Gastroenterol. 1995 Dec;21(4):312-6. Unique Identifier : AIDSLINE MED/96159679; Naghavi R; Saw D; Brady T; Kaplan M; Tagoe C; Department of Medicine, New York Hospital Medical Center of; Queens, Flushing 11355, USA.; Primary gastric T-cell lymphomas are extremely rare. We report a Ki-1 negative primary gastric T-cell lymphoma of the anaplastic large cell type associated with extensive involvement of the skin, gastrointestinal tract, and other organ involvement in a patient not known to be immunocompromized. Biopsy of the stomach a
The endoscopic appearance of severe intestinal Mycobacterium avium complex infection as a coarsely granular mucosa due to massive infiltration and expansion of intestinal villi without mucosal exudation.: J Clin Gastroenterol. 1995 Dec;21(4):323-6. Unique Identifier : AIDSLINE MED/96159682; Cappell MS; Philogene C; Department of Medicine, Maimonides Medical Center, Brooklyn, New; York 11219, USA.; Although Mycobacterium avium complex (MAC) is the most common opportunistic pathogen at postmortem in patients with AIDS, many cases are not recognized premortem. A patient with advanced AIDS had diarrhea, fecal occult blood, and iron deficiency anemia. Esophagogastroduodenoscopy showed an extensive coarsely granular
Primary lymphoma of the esophagus in a patient with AIDS.: J Clin Gastroenterol. 1995 Dec;21(4):327-8. Unique Identifier : AIDSLINE MED/96159683; Moses AE; Rahav G; Bloom AI; Okon E; Polliack A; Maayan S; Zimmerman J; Department of Clinical Microbiology, Hadassah Medical Center,; Hebrew University Medical School, Jerusalem, Israel.
Characterization of cerebral white matter lesions of HTLV-I-associated myelopathy/tropical spastic paraparesis in comparison with multiple sclerosis and collagen-vasculitis: a semiquantitative MRI study.: J Neurol Sci. 1995 Nov;133(1-2):102-11. Unique Identifier : AIDSLINE MED/96154913; Godoy AJ; Kira J; Hasuo K; Goto I; Department of Neurology, Kyushu University, Fukuoka, Japan.; The brain lesions were studied by magnetic resonance imaging (MRI) in 29 HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), 43 multiple sclerosis (MS) (11 with a primary progressive course: PPMS and 32 with a relapsing-remitting course: RRMS), 23 collagen-vasculitis and 54 HTLV-I-seronegative patient
Myasthenia gravis, acute transverse myelitis, and HTLV-I.: J Neurol Sci. 1995 Nov;133(1-2):194-6. Unique Identifier : AIDSLINE MED/96154926; Ijichi T; Adachi Y; Nishio A; Kanaitsuka T; Ohtomo T; Nakamura M; Department of Internal Medicine, Shakaihoken Kobe Central; Hospital, Japan.; We present the unusual case of a 49-year-old female carrier of HTLV-I with myasthenia gravis who presented with acute transverse myelitis. Laboratory data suggested a recent infection with varicella zoster virus and demyelination by an autoimmune process in the central nervous system. Adult T-cell leukemia-like cells
Application of multivariable optimal discriminant analysis in general internal medicine.: J Gen Intern Med. 1995 Nov;10(11):601-6. Unique Identifier : AIDSLINE MED/96162467; Yarnold PR; Soltysik RC; McCormick WC; Burns R; Lin EH; Bush T; Martin GJ; Department of Medicine, Northwestern University Medical School,; Chicago, Illinois 60611, USA.; OBJECTIVE: To illustrate the use of multivariable optimal discriminant analysis (MultiODA). DESIGN: Data from four previously published studies were reanalyzed using MultiODA. The original analysis was Fisher s linear discriminant analysis (FLDA) for two studies and logistic regression analysis (LRA) for two studies.
Photodynamic inactivation of cell-free HIV strains by a red-absorbing chlorin-type photosensitizer.: J Photochem Photobiol B. 1995 Dec;31(3):171-7. Unique Identifier : AIDSLINE MED/96141459; Grandadam M; Ingrand D; Huraux JM; Aveline B; Delgado O; Vever-Bizet C; Brault D; Laboratoire de Virologie du CERVI, CNRS EP 57, Hopital de la; Pitie-Salpetriere, Paris, France.; We have investigated the photodynamic activity of a new chlorin-type photosensitizer on a reference human immunodeficiency virus type 1 (HIV-1) strain, two wild-type HIV-1 isolates and two drug-resistant HIV-1 isolates. This chlorin was highly effective for the inactivation of free viruses, as assessed by two differen
Natural history of HIV-1 infection and predictors of survival in a cohort of HIV-1 seropositive injecting drug users.: J Natl Med Assoc. 1996 Jan;88(1):37-42. Unique Identifier : AIDSLINE MED/96166230; Brown LS Jr; Siddiqui NS; Chu AF; Division of Medical Services, Evaluation and Research, Addiction; Research and Treatment Corporation, Brooklyn, New York 11201,; USA.; Injecting drug users represent a pivotal and increasing component of acquired immunodeficiency syndrome (AIDS) case reporting in the United States . This article describes the natural history of human immunodeficiency virus (HIV) disease in a New York City cohort of 328 HIV-infected inj
[Ocular microangiopathy syndrome in patients with AIDS is associated with increased plasma levels of the vasoconstrictor endothelin-1]: Klin Monatsbl Augenheilkd. 1995 Dec;207(6):353-60. Unique Identifier : AIDSLINE MED/96150945; Geier SA; Rolinski B; Sadri I; Kronawitter U; Bogner JR; Klauss V; Goebel FD; Augenklinik im Universitatsklinikum Rudolf Virchow, Alexander; von Humboldt Universitat Berlin.; OBJECTIVE: Ocular microangiopathic syndrome is the most frequent ophthalmic finding in patients suffering from the acquired immunodeficiency syndrome (AIDS). Ocular microvascular changes including cotton-wool spots are closely associated with neuroretinal and cognitive deficits in patients infected with the human immu
Multiple interspecies transmissions of human and simian T-cell leukemia/lymphoma virus type I sequences.: Mol Biol Evol. 1996 Jan;13(1):115-31. Unique Identifier : AIDSLINE +; Crandall KA; Department of Zoology, University of Texas at Austin 78712-1064,; USA.; Using two sets of nucleotide sequences of the human and simian T-cell leukemia/lymphoma virus type I (HTLV-I/STLV-I), one consisting of 522 bp of the env gene from 70 viral strains and the other a 140-bp segment from the pol gene of 52 viral strains, I estimated cladograms based on a statistical parsimony procedure th
Hypothesis explaining simultaneous development of acquired immunodeficiency syndrome and malignant tumors.: Med Hypotheses. 1995 May;44(5):307-8. Unique Identifier : AIDSLINE MED/96172196; Gogichadze GK; Dolidze TG; Research Institute of Haematology and Blood Transfusion, Tbilisi,; Republic of Georgia.; A possible mechanism for explanation of the simultaneous development of acquired immunodeficiency syndrome (AIDS) and malignant tumors may be based on the cell-fusion process with the participation of immunocompetent cells. If the fusion proceeds with a high intensity, i.e. a great number of cells (including immunocom
[Toxic shock syndrome in AIDS]: Med Klin. 1995 Dec 15;90(12):725-9. Unique Identifier : AIDSLINE MED/96151742; Klinker H; Langmann P; Richter E; Schwinn A; Medizinische Klinik, Universitat Wurzburg.
Primary central nervous system lymphoma.: Neurol Clin. 1995 Nov;13(4):901-14. Unique Identifier : AIDSLINE MED/96157925; Freilich RJ; DeAngelis LM; Department of Neurology, Memorial Sloan-Kettering Cancer Center,; New York, New York, USA.; The rising incidence of PCNSL has allowed a greater understanding of the clinical features and behavior of this once rare tumor. Factors such as dissemination of tumor within the central nervous system, the presence of tumor behind an intact blood-brain barrier, as well as leptomeningeal and ocular involvement must be
Megaloblastic cytopenia in an AIDS patient treated with trimethoprim-sulfamethoxazole.: N C Med J. 1995 Dec;56(12):602-4. Unique Identifier : AIDSLINE MED/96135584; Shami PJ; Crews J; Department of Medicine, Medical Centers, Durham, USA.
Nebraska physicians and AIDS.: Nebr Med J. 1996 Jan;81(1):10-3. Unique Identifier : AIDSLINE MED/96166437; Swindells S; University of Nebraska Medical Center, Omaha 68198-5400, USA.
Lues-lues: maternal and fetal considerations of syphilis.: Obstet Gynecol Surv. 1995 Dec;50(12):845-50. Unique Identifier : AIDSLINE MED/96164290; Ray JG; Department of Medicine, McMaster University, Hamilton, Ontario,; Canada.; Although syphilis occurs infrequently among Canadian and American women, global antenatal screening is still warranted. The reason is that congenitally acquired syphilis is serious, yet largely preventable. Those women at highest risk for the disease seem to be crack and cocaine users, as well as those without antenat
Predicting perinatal human immunodeficiency virus infection by antibody patterns.: Pediatr Infect Dis J. 1995 Oct;14(10):850-2. Unique Identifier : AIDSLINE MED/96117420; Moodley D; Bobat RA; Coutsoudis A; Coovadia HM; Department of Paediatrics and Child Health, Faculty of Medicine,; University of Natal, Durban, South Africa.; The evolution of human immunodeficiency virus type 1 (HIV-1) antibody titers determined by enzyme-linked immunosorbent assay between birth and 18 months of age was investigated in 118 babies born to HIV-1-seropositive South African mothers. By 18 months 41 (34.7%) children were diagnosed as HIV-1-infected by standard
Comparison of the response to antimicrobial therapy of penicillin-resistant and penicillin-susceptible pneumococcal disease.: Pediatr Infect Dis J. 1995 Oct;14(10):885-90. Unique Identifier : AIDSLINE MED/96117427; Friedland IR; Department of Pediatrics, Baragwanath Hospital, South Africa.; The continued spread of penicillin-resistant pneumococci raises therapeutic concerns. Optimal therapy for resistant infections is unknown and it is not clear whether the efficacy of penicillin or equally active beta-lactam agents is compromised in non-meningeal-resistant infections. A prospective nonintervention study
Detection of IgM antibodies to human herpesvirus 6 in Romanian children with nonprogressive human immunodeficiency virus disease.: Pediatr Infect Dis J. 1995 Oct;14(10):891-4. Unique Identifier : AIDSLINE MED/96117428; Nigro G; Luzi G; Krzysztofiak A; D'Orio F; Aiuti F; Pediatric Institute, La Sapienza University, Rome, Italy.; The prevalence of human herpesvirus 6 (HHV-6) infection and the course of human immunodeficiency virus (HIV) disease were investigated in 25 Romanian children with nosocomial HIV-1 infection. HHV-6 IgM and IgG antibodies were detected by enzyme immunoassay (EIA) and immunofluorescence assay (IFA) at the beginning of t
High efficiency of vertical transmission of hepatitis C virus among babies born to human immunodeficiency virus-negative women [letter]: Pediatr Infect Dis J. 1995 Oct;14(10):921-2. Unique Identifier : AIDSLINE MED/96117443; Maccabruni A; Bossi G; Caselli D; Cividini A; Silini E; Mondelli MU
Toxoplasmosis diagnosis in pregnant women infected with human immunodeficiency virus I [letter]: Pediatr Infect Dis J. 1995 Nov;14(11):1016-7. Unique Identifier : AIDSLINE MED/96147546; Hassl A; Tuma W
Disseminated Penicillium marneffei infection in human immunodeficiency virus-infected children.: Pediatr Infect Dis J. 1995 Nov;14(11):935-40. Unique Identifier : AIDSLINE MED/96147524; Sirisanthana V; Sirisanthana T; Faculty of Medicine, Chiang Mai University, Thailand.; Disseminated infection with the fungus Penicillium marneffei is one of the most common opportunistic infections in human immunodeficiency virus (HIV) disease in northern Thailand . We report the clinical, laboratory and therapeutic features of 21 human immunodeficiency virus-infec
Mother-to-child transmission of human immunodeficiency virus type 1 and type 2 and dual infection: a cohort study in Banfora, Burkina Faso.: Pediatr Infect Dis J. 1995 Nov;14(11):940-7. Unique Identifier : AIDSLINE MED/96147525; Prazuck T; Yameogo JM; Heylinck B; Ouedraogo LT; Rochereau A; Guiard-Schmid JB; Lechuga P; Agranat P; Cot M; Malkin JE; et al; Groupe d'Etudes Epidemiologiques et Prophylactiques (GEEP),; Centre Hospitalier, France.; A prospective cohort study on the mother-to-child transmission of human immunodeficiency virus type 1 (HIV1), type 2 (HIV2) and dual positivity (HIV1 + HIV2) was carried out in Banfora, West Burkina Faso . The study samples consist of 117 newborns of HIV-seropositive women matched
Comparison of a rapid nonisotopic polymerase chain reaction assay with four commonly used methods for the early diagnosis of human immunodeficiency virus type 1 infection in neonates and children.: Pediatr Infect Dis J. 1995 Nov;14(11):948-54. Unique Identifier : AIDSLINE MED/96147526; Kovacs A; Xu J; Rasheed S; Li XL; Kogan T; Lee M; Liu C; Chan L; Comprehensive Maternal-Child HIV Management and Research Center,; Los Angeles County and University of Southern California Medical; Center 90033, USA.; To initiate antiretroviral therapy and prophylaxis for Pneumocystis carinii pneumonia, it is important to identify human immunodeficiency virus (HIV-1)-infected infants as soon after birth as possible. This study was undertaken to evaluate a novel 5-hour nonisotopic (NI) polymerase chain reaction (PCR) assay (Amplicor
Tuberculosis infection in human immunodeficiency virus-positive adolescents and young adults: a New York City cohort.: Pediatrics. 1996 Feb;97(2):198-203. Unique Identifier : AIDSLINE MED/96160384; Hoffman ND; Kelly C; Futterman D; Adolescent AIDS Program, Montefiore Medical Center, Bronx, NY; 10467, USA.; OBJECTIVES: Adolescents with human immunodeficiency virus (HIV) infection are at increased risk for tuberculosis (TB), underscoring the importance of early identification of TB infection. The goals of this study were to assess the factors associated with the completion of evaluations for TB in a cohort of HIV-positive
Condom availability for youth: a high-risk alternative [letter]: Pediatrics. 1996 Feb;97(2):285; discussion 286. Unique Identifier : AIDSLINE MED/96160405; Friedman Z; Trivelli L
Condom availability for youth: a high-risk alternative [letter]: Pediatrics. 1996 Feb;97(2):285-6. Unique Identifier : AIDSLINE MED/96160406; Colliton WF Jr
Characterization of the MN gp120 HIV-1 vaccine: antigen binding to alum.: Pharm Res. 1995 Oct;12(10):1439-46. Unique Identifier : AIDSLINE MED/96117505; Weissburg RP; Berman PW; Cleland JL; Eastman D; Farina F; Frie S; Lim A; Mordenti J; Peterson MR; Yim K; et al; Pharmaceutical R&D, Genentech, Inc, South San Francisco,; California 94080, USA.; PURPOSE. The characterization of recombinant MN gp120/alum vaccine requires the study of the gp120-alum interaction for the successful formulation of an alum-based HIV-1 vaccine. METHODS. Several observations suggest that the gp120-alum interaction is weak, wherein buffer counterions such as phosphate, sulfate, bicarb
The effect of food on pharmacokinetics of zalcitabine in HIV-positive patients.: Pharm Res. 1995 Oct;12(10):1462-5. Unique Identifier : AIDSLINE MED/96117509; Nazareno LA; Holazo AA; Limjuco R; Passe S; Twardy SK; Min B; Massarella JW; Hoffmann-La Roche Inc., Department of Clinical Pharmacology,; Nutley, New Jersey 07110, USA.; PURPOSE. The purpose of this study was to determine the effect of food on the pharmacokinetics of zalcitabine in HIV-positive patients. METHODS. Twenty patients received single oral 1.5 mg doses of zalcitabine with and without a standard breakfast in an open-label, randomized crossover study with at least a one week w
[Diagnostic value of protected bronchoalveolar lavage in HIV-associated pneumonia]: Pneumologie. 1995 Oct;49(10):546-55. Unique Identifier : AIDSLINE MED/96110071; Ewig S; Moter A; Nachtsheim KH; Seuffert HM; Marklein G; Schumacher R; Eis G; Leutner C; Bauer T; Reichel C; et al; Medizinische Universitatsklinik und Poliklinik, Institut fur; Medizinische Mikrobiologie und Immunologie, Bonn.; OBJECTIVE: The concept of the protected bronchoalveolar lavage (PBAL) is to improve the diagnostic yield in bacterial pneumonia by unifying the high sensitivity of bronchoalveolar lavage (BAL) and specificity of the protected specimen brush (PSB). HIV-infected patients have been shown to have a high incidence of bacte
Confidentiality of HIV medical records: the computer age.: Prog Cardiovasc Nurs. 1995 Fall;10(4):39-43, 45. Unique Identifier : AIDSLINE MED/96162778; Byrd CM; Baulch MN; University of San Francisco, CA, USA.
[Diseases relevant to gene therapy]: Tanpakushitsu Kakusan Koso. 1995 Dec;40(17):2496-7. Unique Identifier : AIDSLINE MED/96143769; Niitsu Y; Fourth Department of Internal Medicine, Sappro Medical University; School of Medicine, Japan.
[Gene transfer using recombinant