1996

Interferon-gamma-induced downregulation of CD4 inhibits the entry of human immunodeficiency virus type-1 in primary monocytes.: Pathobiology. 1995;63(2):93-9. Unique Identifier : AIDSLINE MED/96108566; Dhawan S; Heredia A; Wahl LM; Epstein JS; Meltzer MS; Hewlett IK; Laboratory of Molecular Virology, Food and Drug Administration,; Rockville, Md., USA.; We have previously shown that the treatment of monocytes with interferon-gamma (IFN-gamma) prior to exposure with human immunodeficiency virus type-1 (HIV) results in complete inhibition of HIV infection of monocytes. In the present report, we have extended this study to obtain information on the mechanism(s) underlyi
The accurate diagnosis of oral lesions in human immunodeficiency virus infection. Impact on medical staging.: Arch Otolaryngol Head Neck Surg. 1996 Jan;122(1):68-73. Unique Identifier : AIDSLINE MED/96133394; Cruz GD; Lamster IB; Begg MD; Phelan JA; Gorman JM; el-Sadr W; New York City (NY) Department of Health, USA.; OBJECTIVE: To compare identification of oral candidiasis (OC) and oral hairy leukoplakia (OHL) by medical examiners and oral/dental examiners and to assess the impact of these diagnoses on the medical staging of the human immunodeficiency virus (HIV). DESIGN: Retrospective analysis of data collected by medical and ora
Analysis and localization of cyclophilin A found in the virions of human immunodeficiency virus type 1 MN strain.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1003-6. Unique Identifier : AIDSLINE MED/96089206; Ott DE; Coren LV; Johnson DG; Sowder RC 2nd; Arthur LO; Henderson LE; AIDS Vaccine Program, National Cancer Institute, Frederick Cancer; Research and Development Center, Maryland 21702-1201, USA.; Previous reports have shown that cyclophilin A (CyPA) is found to be specifically associated with human immunodeficiency virus type-1 (HIV-1) virions and is required for infectivity (Franke et al. Nature 372:359; Thali et al. Nature 372:363). We have examined CyPA associated with HIV-1MN virions. Virions from infected
HIV acquires functional adhesion receptors from host cells.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1007-13. Unique Identifier : AIDSLINE MED/96089207; Guo MM; Hildreth JE; Department of Pharmacology and Molecular Sciences, Johns Hopkins; University School of Medicine, Baltimore, Maryland 21205, USA.; CD4 is known to serve as the principal cellular receptor for HIV. However, several observations suggest that other molecules may be involved in infection of cells by HIV. Cell adhesion molecules and their ligands expressed on HIV-susceptible cells have been implicated in the biology of HIV in a number of studies. We h
Enhanced susceptibility to human immunodeficiency virus infection in CD4+ T lymphocytes genetically deficient in CD43.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1015-21. Unique Identifier : AIDSLINE MED/96089208; Srinivas RV; Su T; Trimble LA; Lieberman J; Ardman B; Department of Infectious Diseases, St. Jude Children's Research; Hospital, Memphis, Tennessee 38105, USA.; CD43 is a cell surface sialoglycoprotein expressed by most cells of hematopoietic origin, including all T lymphocytes. Elimination of CD43 expression by gene targeting in the CEM T cell line results in its increased homotypic adhesion and binding to HIV-1 gp120. Here we report that the CD43-negative CEM cells show inc
Kinetics of HIV infection of human placental syncytiotrophoblast cultures: an ultrastructural and immunocytochemical study.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1023-30. Unique Identifier : AIDSLINE MED/96089209; Fazely F; Fry GN; Thirkill TL; Hakim H; King BF; Douglas GC; Department of Medical Pathology, School of Medicine, University; of California, Davis 95616, USA.; We previously demonstrated that syncytiotrophoblast (ST) cells from term human placentas could be infected when cocultured with HIV-infected lymphocytic cells. Here, we have used fluorescence microscopy and transmission electron microscopy to examine the kinetics of this infection process. Molt-4 clone 8 cells infecte
Suppression of HIV replication in human monocyte-derived macrophages induced by granulocyte/macrophage colony-stimulating factor.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1031-8. Unique Identifier : AIDSLINE MED/96089210; Matsuda S; Akagawa K; Honda M; Yokota Y; Takebe Y; Takemori T; AIDS Research Center, National Institute of Health, Tokyo, Japan.; Susceptibility to HIV infection was examined in macrophages differentiated from human monocytes by macrophage colony-stimulating factor (M-CSF) or granulocyte/macrophage colony-stimulating factor (GM-CSF). The replication of macrophage-tropic human immunodeficiency virus type-1 (HIV-1), which was determined by reverse
HIV type 1 extracellular Tat protein stimulates growth and protects cells of BK virus/tat transgenic mice from apoptosis.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1039-48. Unique Identifier : AIDSLINE MED/96089211; Campioni D; Corallini A; Zauli G; Possati L; Altavilla G; Barbanti-Brodano G; Institute of Microbiology, School of Medicine, University of; Ferrara, Italy.; Cells from BKV/tat transgenic mice were characterized for their tumorigenic phenotype in nude and syngeneic BDF mice. The results indicate that the BKV/tat recombinant transgene has a weak tumorigenic potential, mostly predisposing to oncogenesis, and that second events are required for the development of tumorigenici
Iron chelation decreases NF-kappa B and HIV type 1 activation due to oxidative stress.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1049-61. Unique Identifier : AIDSLINE MED/96089212; Sappey C; Boelaert JR; Legrand-Poels S; Forceille C; Favier A; Piette J; Laboratory of Virology, University of Liege, Belgium.; An important aspect of human immunodeficiency virus (HIV-1) infection is the regulation of its expression by nuclear factor kappa B (NF-kappa B) through redox-controlled signal transduction pathways. In this study, we demonstrate that iron chelation by deferoxamine (DFO) protects against the cytotoxic and reactivating
Intracellular trafficking of the human immunodeficiency virus type 1 Rev protein: involvement of continued rRNA synthesis in nuclear retention.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1063-71. Unique Identifier : AIDSLINE MED/96089213; D'Agostino DM; Ciminale V; Pavlakis GN; Chieco-Bianchi L; Institute of Oncology, University of Padova, Italy.; We have explored the mechanism directing the intracellular trafficking and nucleolar accumulation of the human immunodeficiency virus type 1 (HIV-1) Rev protein. Treatment of Rev-expressing cells with mycophenolic acid, an inhibitor of inosine monophosphate dehydrogenase, resulted in a redistribution of Rev from the n
Development of a human thymic organ culture model for the study of HIV pathogenesis.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1073-80. Unique Identifier : AIDSLINE MED/96089214; Bonyhadi ML; Su L; Auten J; McCune JM; Kaneshima H; HIV Group, SyStemix, Inc., Palo Alto, California 94304, USA.; The development of effective therapies for the treatment of AIDS would be facilitated by a better understanding of HIV pathogenesis in vivo. While some aspects of pathogenesis may be assessed by standard tissue culture assays, in vivo animal models may provide clues to other aspects of HIV-mediated progression toward
Rapid molecular epidemiology of human immunodeficiency virus transmission.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1081-93. Unique Identifier : AIDSLINE MED/96089215; Delwart EL; Busch MP; Kalish ML; Mosley JW; Mullins JI; Aaron Diamond AIDS Research Center, New York University School of; Medicine, New York 10016, USA.; Close sequence homology between strains of HIV-1 have been used to corroborate cases of epidemiologically identified transmission. As an alternative to extensive DNA sequence analysis, genetic relateness between pairs of HIV quasispecies was estimated using the reduced electrophoretic mobilities of HIV-1 envelope DNA
Functional activities of 20 human immunodeficiency virus type 1 (HIV-1)-specific human monoclonal antibodies.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1095-9. Unique Identifier : AIDSLINE MED/96089216; Forthal DN; Landucci G; Gorny MK; Zolla-Pazner S; Robinson WE Jr; Department of Medicine, University of California, Irvine College; of Medicine, Orange 92668, USA.; Antibodies that are useful in the treatment of HIV infection should result in virus neutralization or lysis of infected cells but should not enhance infection. In this study, the potential clinical use of 20 HIV-1-specific human monoclonal antibodies (HuMAbs) was determined by measuring their enhancing (C-ADE) activit
Alanine substitution of two arginines in amino terminus of V3 of SIV disrupts CD4 binding whereas a similar replacement of two amino acids, lysine and arginine, in the carboxyl half of V3 prevents binding of a neutralizing monoclonal antibody.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1101-5. Unique Identifier : AIDSLINE MED/96089217; Javaherian K; Zuchowski L; Clark FT; Repligen Corporation, Cambridge, Massachusetts 02139, USA.; A series of amino acid substitutions were carried out in the V3 loop of SIV gp120 to investigate their effects on binding of the envelope to CD4 and neutralizing monoclonal antibodies. Alanine replacement of two adjacent arginines at the amino terminus of V3 resulted in a molecule that bound neither sCD4 nor conformat
Involvement of gag- and env-specific cytotoxic T lymphocytes in protective immunity to feline immunodeficiency virus.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1107-13. Unique Identifier : AIDSLINE MED/96089218; Flynn JN; Beatty JA; Cannon CA; Stephens EB; Hosie MJ; Neil JC; Jarrett O; Department of Veterinary Pathology, University of Glasgow,; Bearsden, Scotland.; Definition of the immunological mechanisms involved in protective immunity against lentiviral infections is crucial to the development of an effective vaccine. The induction of gag- and env-specific cell-mediated immune responses was studied in cats following vaccination with whole inactivated feline immunodeficiency
HTLV-I activates complement leading to increased binding to complement receptor-positive cells.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1115-22. Unique Identifier : AIDSLINE MED/96089219; Saifuddin M; Landay AL; Ghassemi M; Patki C; Spear GT; Department of Immunology/Microbiology, Rush University, Chicago,; Illinois 60612, USA.; This investigation was performed to determine whether HTLV-I can activate complement, since previous studies show that complement activation by some viruses, including HIV-1, can enhance binding to, and infection of complement receptor-positive (CR+) cells. Complement treatment increased binding of HTLV-I to CR+ HPB-A
Characterization of a transcriptional attenuator within the 5' R region of the human T cell leukemia virus type 1.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1123-9. Unique Identifier : AIDSLINE MED/96089220; Montagne J; Jalinot P; Laboratoire de Biologie Moleculaire et Cellulaire, CNRS UMR49,; Ecole Normale Superieure de Lyon, France.; Several regulatory sequences have been characterized in the HTLV-I promoter. We report here identification of a sequence element downstream of the transcriptional start site within the first 52 nucleotides of the 5 R region, which acts negatively on the activity of the HTLV-I promoter. Determination of the half-lives
Does the key to a successful HIV type 1 vaccine lie among the envelope sequences of infected individuals?: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1131-3. Unique Identifier : AIDSLINE +; Rencher SD; Slobod KS; Dawson DH; Lockey TD; Hurwitz JL; Department of Immunology, St. Jude Children's Research Hospital,; Memphis, Tennessee, USA.
Analysis of the V3 loop sequences from 10 HIV type 1-infected AIDS patients from Paraguay.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1135-7. Unique Identifier : AIDSLINE MED/96089222; Cabello A; Cabral M; Vera ME; Kiefer R; Azorero RM; Eberle J; Gurtler L; Von Brunn A; Instituto de Investigaciones en Ciencias de la Salud, Universidad; Nacional de Asuncion, Paraguay.
Highly divergent env sequences of HIV-1 B subtype with two novel V3 loop motifs detected in an AIDS patient in Miami, Florida.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1139-41. Unique Identifier : AIDSLINE MED/96089223; Xin KQ; Shapshak P; Kawamoto S; Nagano I; McCoy CB; Okuda K; Department of Psychiatry, University of Miami Medical School,; Florida 33136, USA.
Sequence and phylogenetic analysis of glycoprotein 120 of an HIV type 1 variant (GWGR) prevalent in Brazil.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1143-5. Unique Identifier : AIDSLINE MED/96089224; da Costa SM; Schechter M; Shindo N; Vicente AC; Oliveira EF; Pinto ME; Tanuri A; Departamento de Genetica, Universidade Federal do Rio de; Janeiro, Brazil.
Molecular characterization of an HIV type 1 isolate from Burundi.: AIDS Res Hum Retroviruses. 1995 Sep;11(9):1146. Unique Identifier : AIDSLINE MED/96089225; Ranjbar
Apparent bypass of negative selection in CD8+ tumours in CD2-myc transgenic mice.: Br J Cancer. 1996 Jan;73(1):13-7. Unique Identifier : AIDSLINE MED/96146594; Cameron ER; Campbell M; Blyth K; Argyle SA; Keanie L; Neil JC; Onions DE; Department of Veterinary Pathology, University of Glasgow; Veterinary School, UK.; A role for antigen stimulation in lymphoid neoplasia has been postulated and is supported by indirect evidence that suggests that the interaction of antigen with both T cells and B cells may constitute an epigenetic event that can contribute to tumour induction or tumour progression. Using myc-bearing transgenic mice
Outreach work in HIV prevention effective [news]: Nurs Stand. 1995 Nov 22-28;10(9):14. Unique Identifier : AIDSLINE MED/96153242; Blakey V; Franklan J
Efficacy of ultraviolet B phototherapy for psoriasis in patients infected with human immunodeficiency virus.: Photodermatol Photoimmunol Photomed. 1995 Jun;11(3):107-11. Unique Identifier : AIDSLINE MED/96139930; Fotiades J; Lim HW; Jiang SB; Soter NA; Sanchez M; Moy J; Ronald O. Perelman Department of Dermatology, New York University; School of Medicine, NY 10016, USA.; To evaluate the efficacy of ultraviolet B (UVB) phototherapy for the treatment of psoriasis in patients infected with human immunodeficiency virus (HIV), the response of 14 patients was compared to that of matched seronegative control individuals. All patients were evaluated prior to treatment (baseline) and after 21
HIV disease and Malassezia yeasts: a quantitative study of patients presenting with seborrhoeic dermatitis.: Br J Dermatol. 1995 Nov;133(5):694-8. Unique Identifier : AIDSLINE MED/96142527; Schechtman RC; Midgley G; Hay RJ; Medical Mycology Department, St John's Institute of Dermatology,; St Thomas' Hospital, London, U.K.; Seborrhoeic dermatitis (SD) is a disease that affects 1-3% of the general population, 3-5% of young adults and 20-83% of patients with AIDS. Malassezia yeasts have been associated with the pathogenesis of this condition. The association between the Malassezia yeasts and HIV-related SD is still a controversial subject.
Pityriasis rubra pilaris and HIV infection: a part of the spectrum of HIV-associated follicular syndrome [letter]: Br J Dermatol. 1995 Nov;133(5):818-9. Unique Identifier : AIDSLINE MED/96142556; Sanchez-Regana M; Fuentes CG; Creus L; Salleras M; Umbert P
Autoimmune mechanisms of depletion of CD4 cells in HIV infection.: Br J Haematol. 1995 Nov;91(3):525-34. Unique Identifier : AIDSLINE MED/96048888; Dalgleish AG; Division of Oncology, St George's Hospital Medical School,; London.
Decreased potency of MDR-modulators under serum conditions determined by a functional assay.: Br J Haematol. 1995 Nov;91(3):652-7. Unique Identifier : AIDSLINE MED/96048907; Ludescher C; Eisterer W; Hilbe W; Hofmann J; Thaler J; Department of Internal Medicine, University of Innsbruck,; Austria.; A variety of agents are capable of overcoming P-glycoprotein-mediated multidrug resistance (MDR) in vitro. However, the clinical potential of these compounds is often limited due to high plasma protein binding. We compared the efficacy of several MDR-reversing compounds in serum-free culture medium and under serum con
Persistent hepatitis C virus RNA replication in haemophiliacs: role of co-infection with human immunodeficiency virus.: Br J Haematol. 1995 Nov;91(3):703-7. Unique Identifier : AIDSLINE MED/96048917; Chambost H; Gerolami V; Halfon P; Thuret I; Michel G; Sicardi F; Rousseau S; Perrimond H; Cartouzou G; Service d'Hematologie Pediatrique, CHU Timone, Marseille,; France.; In order to evaluate the evolution of transfusional hepatitis C in haemophiliacs, we performed a retrospective study of ALT levels and HCV viraemia with a RNA PCR assay in 57 patients. We found that the vast majority of HCV-infected patients remained viraemic (43/57 = 75%) and higher ALT levels correlated with HCV vir
Hepatitis C virus genotypes and severity of chronic liver disease in haemophiliacs.: Br J Haematol. 1995 Nov;91(3):708-13. Unique Identifier : AIDSLINE MED/96048918; Tagariello G; Pontisso P; Davoli PG; Ruvoletto MG; Traldi A; Alberti A; Centre for Blood Diseases, Castelfranco Veneto Hospital, TV,; Italy.; We studied the activity and stage of chronic liver disease in 45 HCV-seropositive/HIV-seronegative patients with severe haemophilia followed for at least 10 years. HCV-RNA was detected in serum in 36 patients (80%) Viraemic cases were further analysed for HCV genotypes: 10 (28%) were infected by type 1a, 10 (28%) by t
Effect of human immunodeficiency virus type 1 (HIV-1) nucleocapsid protein on HIV-1 reverse transcriptase activity in vitro.: Biochemistry. 1996 Jan 9;35(1):132-43. Unique Identifier : AIDSLINE MED/96134828; Ji X; Klarmann GJ; Preston BD; Department of Biochemistry, University of Utah, Salt Lake City; 84112, USA.; Conversion of human immunodeficiency virus type 1 (HIV-1) genomic RNA to viral DNA is a requisite step in the virus life cycle. This conversion is catalyzed by reverse transcriptase (RT) associated with a large nucleoprotein complex composed of several viral proteins including nucleocapsid (NC). To better characterize
Extension of the polarity-dependent switch phenomenon of the gp120 binding domain as a target for antiviral chemotherapy.: Biochemistry. 1996 Jan 16;35(2):411-7. Unique Identifier : AIDSLINE MED/96140213; Graf von Stosch A; Kinzel V; Reed J; Department of Pathochemistry, German Cancer Research Center,; Heidelberg, Germany.; A 15-residue fragment within the major continuous domain of gp120 from HIV-1 that can bind independently to the CD4 receptor has been shown to have the property of behaving as a solvent polarity-dependent conformational switch. The switch behavior (cooperative transition from beta-sheet to helical conformation as a fu
Public policy statement on primary medical care for HIV infected patients in addiction treatment.: J Addict Dis. 1995;14(3):129-30. Unique Identifier : AIDSLINE MED/96127017
Public policy statement on HIV testing of patients in addiction treatment facilities.: J Addict Dis. 1995;14(3):131-3. Unique Identifier : AIDSLINE MED/96127018
Seroprevalence and risk factors associated with HTLV-I/II infection in injection drug users in northern New Jersey.: J Addict Dis. 1995;14(3):51-66. Unique Identifier : AIDSLINE MED/96127013; Freeman RC; Rodriguez GM; French JF; New Jersey State Department of Health, Division of Alcoholism,; Drug Abuse, and Addiction Services, Newark, USA.; Data from an AIDS Demonstration Research project in Paterson, NJ, that enrolled out-of-treatment injection drug users (IDUs) were analyzed to detect demographic patterns and risk factors associated with infection with human immunodeficiency virus (HIV) and human T-lymphotropic virus types I or II (HTLV-I/II). Of 410 I
[Pneumocystis carinii infection in AIDS patients. Current prognosis of the respiratory insufficiency (editorial)]: Enferm Infecc Microbiol Clin. 1995 Oct;13(8):447-9. Unique Identifier : AIDSLINE MED/96079579; Rello J; Villagra A; Cervantes M
[Didanosine]: Enferm Infecc Microbiol Clin. 1995 Oct;13(8):487-90. Unique Identifier : AIDSLINE MED/96079589
[Attempted suicide using massive doses of zidovudine (letter)]: Enferm Infecc Microbiol Clin. 1995 Oct;13(8):494-5. Unique Identifier : AIDSLINE MED/96079592; Perez-Molina JA; Canas P; Casado JL
[Epidemiology of a hospital outbreak of scabies (letter)]: Enferm Infecc Microbiol Clin. 1995 Oct;13(8):495-6. Unique Identifier : AIDSLINE MED/96079593; Ortega L; Sierra M; Cid R; Rodriguez T; Aparicio M
[Ulcer in the urethral meatus and HIV infection (letter)]: Enferm Infecc Microbiol Clin. 1995 Oct;13(8):497-8. Unique Identifier : AIDSLINE MED/96079596; Len O; de Otero J; Ribera E; Ocana I
Infective complications after minor operations in patients infected with HIV: role of CD4 lymphocytes in prognosis.: Eur J Surg. 1995 Oct;161(10):721-3. Unique Identifier : AIDSLINE MED/96136956; Emparan C; Iturburu IM; Portugal V; Apecechea A; Bilbao JE; Mendez JJ; Department of Surgery, Universidad del Pais Vasco, General; Surgery B, Hospital de Basurto, Bilbao, Spain.; OBJECTIVE: To find out the incidence of wound infection in patients with HIV and reduced counts of CD4 lymphocytes. DESIGN: Open study. SETTING: University hospital, Spain . SUBJECTS: 70 patients with HIV infection and enlarged lymph nodes. INTERVENTIONS: Biopsy of lymph nodes and wi
[Fusion of negatively-charged liposomes under the effect of peptides from the N-terminal fragment of the HIV-1 transmembrane protein]: Biokhimiia. 1995 Oct;60(10):1711-9. Unique Identifier : AIDSLINE MED/96098219; Terletskaia IaT; Trikash IO; Serdiuk ES; Andreev SM; The effect of a series of synthetic peptides mimicking the N-terminus of HIV transmembrane glycoprotein (gp41) on fusion of negatively charged liposomes consisting of phosphatidylcholine, phosphatidylethanolamine and cardiolipin at a 2:3:5 molar ratio, respectively, has been studied. Peptides P514 and P385 (residue 51
Complete remission in severe aplastic anemia after high-dose cyclophosphamide without bone marrow transplantation.: Blood. 1996 Jan 15;87(2):491-4. Unique Identifier : AIDSLINE MED/96141068; Brodsky RA; Sensenbrenner LL; Jones RJ; Johns Hopkins Oncology Center, Johns Hopkins Medical; Institutions, Baltimore, MD 21287-8967, USA.; Severe aplastic anemia (SAA) can be successfully treated with allogeneic bone marrow transplantation (BMT) or immunosuppressive therapy. However, the majority of patients with SAA are not eligible for BMT because they lack an HLA-identical sibling. Conventional immunosuppressive therapy also has major limitations; man
Persistent activation of the tumor necrosis factor system in a subgroup of patients with common variable immunodeficiency--possible immunologic and clinical consequences.: Blood. 1996 Jan 15;87(2):674-81. Unique Identifier : AIDSLINE MED/96141088; Aukrust P; Lien E; Kristoffersen AK; Muller F; Haug CJ; Espevik T; Froland SS; Medical Department A, National Hospital, University of Oslo,; Norway.; In patients with common variable immunodeficiency (CVI), we have previously defined a subgroup of patients (CVIHyper) characterized by decreased numbers of CD4+ lymphocytes in peripheral blood, splenomegaly, and persistent immune activation in vivo, particularly of monocytes/macrophages. To further characterize this h
Hepatitis C virus RNA in patients with anti-HCV on hemodialysis. Relationship to transaminase levels.: ASAIO J. 1994 Jul-Sep;40(3):M450-3. Unique Identifier : AIDSLINE MED/96145400; Garcia-Valdecasas J; Bernal C; Cerezo S; Garcia F; Montiel N; Leyva A; Umana WO; Bosch JP; Department of Medicine, Hospital Universitario, University of; Granada, Spain.; This study was performed in patients with hepatitis C virus (HCV) who were treated with hemodialysis to determine the relationships among alanine amino-transferase (ALT) levels, immunoglobulin (Ig) G anti-HCV, IgM anti-HCV core, and HCV RNA. Of 107 patients on hemodialysis, 27 had positive IgG anti-HCV. Eight of the p
Cell cycle inhibition of HTLV-I transformed T cell lines by retinoic acid: the possible therapeutic use of thioredoxin reductase inhibitors.: Oncol Res. 1995;7(3-4):183-9. Unique Identifier : AIDSLINE MED/96170919; U-Taniguchi Y; Furuke K; Masutani H; Nakamura H; Yodoi J; Institute for Virus Research, Kyoto University, Japan.; Adult T cell leukemia derived factor (ADF), which was first reported as a cytokine-like factor produced by human T lymphotropic virus I (HTLV-I)-transformed T cells, is a human homologue of thioredoxin (TRX). ADF/TRX has multiple functions including growth promoting, antiapoptotic and radical scavenging activities, an
Ovine lentivirus infection: an animal model for pediatric HIV infection?: Arch Med Res. 1995 Winter;26(4):345-54. Unique Identifier : AIDSLINE MED/96107853; de la Concha-Bermejillo A; Juste RA; Kretschmer R; Aguilar Setien A; Department of Pathology, Texas A & M University Agricultural; Experiment Station, San Angelo, USA.; While the incidence of the human immunodeficiency virus (HIV) infection has leveled off somewhat in homosexual men, infection in women, children and adolescents is rising. Unless effective preventive measures are introduced, the number of pediatric patients with HIV and related illnesses will continue to increase. Ani
Clinical neurophysiological comparative study on HTLV-1 associated myelopathy/tropical spastic paraparesis.: Arch Med Res. 1995 Winter;26(4):397-403. Unique Identifier : AIDSLINE MED/96107859; Leon FE; Arimura K; Arimura Y; Sonoda Y; Suwazono S; Osame M; Third Department of Internal Medicine, Kagoshima University; School of Medicine, Japan.; In order to determine the neurophysiological characteristics of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) throughout the world, we analyzed and compared the most common clinical neurophysiological studies (CNPS) performed in this entity from those places with a high prevalence and interesting
[The seroprevalence of human immunodeficiency virus infection (HIV) in patients with tuberculosis at the National Hospital of Niamey, Niger (1990-1991)]: Bull Soc Pathol Exot. 1995;88(3):121-3. Unique Identifier : AIDSLINE MED/96150686; Ousseini H; Kim DS; Adamou A; Faculte des Sciences de la Sante, Niamey, Niger.; This study has been planned in order to determinate the frequency of the infection by VIH among the 394 new tuberculous, for a period extended from July 1990 to July 1991 at the section of pneumophtisiology in the National Hospital of Niamey. The number of seropositives is 7.6%. The two types of viruses, i.e. VIH1 and
[The seroprevalence of human immunodeficiency virus infection (HIV) in the Touaregs and Peuls Bororo in Niger]: Bull Soc Pathol Exot. 1995;88(3):124-5. Unique Identifier : AIDSLINE MED/96150687; Ousseini H; Meynard D; Soumana Adamou H; Faculte des Sciences de la Sante, Niamey, Niger.; A seroepidemiological study of endemic treponematosis (bejel) in Niger allows us to realise an anonymous non correlated screening of VIH infection in Nomads: Touaregs of Tchirozerine (Agadez), Peuls Boro of Bermo (Maradi). On the 424 Touaregs screened only one was seropositive to VI
[Seroprevalence of rickettsial infections of the Boutonneuse fever group or its apparent group in Bangui (Central African Republic)]: Bull Soc Pathol Exot. 1995;88(3):126-8. Unique Identifier : AIDSLINE MED/96150688; Ekala MT; Gresenguet G; Belec L; Laboratoire de Virologie, Hopital Broussais, Paris, France.; 115 sera from African individuals, including 66 HIV-1-infected individuals and 49 HIV-seronegative age-matched healthy controls, living in Bangui, Central African Republic , were screened for Rickettsia conorii antibody by indirect immunofluorescent assay; 53 (46%) s
[Intra-family transmission of human T-cell lymphotropic virus-1 (HTLV-1) in a cohort of HTLV-1-positive patients (Benin)]: Bull Soc Pathol Exot. 1995;88(3):79-80. Unique Identifier : AIDSLINE MED/96150674; Houinato D; Verdier M; Josse R; Foundohou J; Preux PM; Avode G; Zohoun T; Denis F; Dumas M; Institut d'Epidemiologie neurologique et de neurologie; tropicale, Limoges.; We are reporting the results of a familial study carried out in Benin in March 1994 within a cohort of HTLV-1 positive subjects. This study aims at appraising the different modes of intra-familial transmission of this retrovirus. The study has included 212 persons: 33 seropositive s
[Pulmonary abscess in Lome. Apropos of 144 cases collected in the Pneumo-Phthisiology Department of the University Hospital Center-Tokoin from 1981-1993]: Bull Soc Pathol Exot. 1995;88(3):95-6. Unique Identifier : AIDSLINE MED/96150678; Tidjani O; Gbadoe AH; Grunitzky-Bekele M; Adjadja K; Lawson-Apetoh A; Djinadou G; Service de Pneumo-phtisiologie et des Maladies Infectieuses,; CHU-Tokoin, Lome, Togo.; The authors report the results of a retrospective study of 144 cases of lung abscess observed in the Pneumo-Phthisiology Department of Tokoin University Teaching Hospital of Lome ( Togo ) between 1981 and 1993 for to determine epidemiological, clinical, therapeutical and evolutive aspe
Science throws light on HIV suppression [news]: BMJ. 1995 Dec 16;311(7020):1591. Unique Identifier : AIDSLINE MED/96111851; Boulton A
Notification of tuberculosis is compatible with venereal diseases regulations [letter]: BMJ. 1995 Dec 16;311(7020):1642. Unique Identifier : AIDSLINE MED/96111886; Metters JS
Incidence of HIV infection decreases because of nature of epidemics [letter]: BMJ. 1996 Jan 13;312(7023):125. Unique Identifier : AIDSLINE MED/96141956; Brody S
HIV prevalence and risk behaviour among intravenous drug users attending HIV counselling and testing centres in Paris.: Addiction. 1995 Dec;90(12):1627-33. Unique Identifier : AIDSLINE MED/96127656; Helal H; Momas I; Pretet S; Marsal L; Poinsard R; Centre d'information et de depistage anonyme et gratuit du VIH,; Paris, France.; This study was designed to analyse sexual and drug use behaviour, to determine whether increased awareness can lead to behaviour change, and to evaluate the association between HIV seropositivity and potential risk factors. A 4-month survey was carried out on 147 IVDUs attending three HIV counselling and testing centr
The role of needle exchanges in modifying sharing behaviour: cross-study comparisons 1989-1993.: Addiction. 1995 Dec;90(12):1635-45. Unique Identifier : AIDSLINE MED/96127657; Klee H; Morris J; Manchester Metropolitan University, Department of Psychology, UK.; In this paper the relationship between sharing behaviour and needle-exchange attendance is examined. Data from three studies of drug misuse carried out consecutively from 1989 to 1993 in the north-west of England are compared. Samples differed in their drug preferences. Analyses of sharing injecting equipment comparin
The need to preserve historical material [letter]: Addiction. 1995 Dec;90(12):1683. Unique Identifier : AIDSLINE MED/96127661; Berridge V
MHC class I-selected CD4-CD8-TCR alpha beta+ T cells: an important source of IL-4.: Braz J Med Biol Res. 1995 Aug;28(8):903-5. Unique Identifier : AIDSLINE MED/96098120; Leite-de-Moraes MC; Dy M; Universite Rene Descartes, Paris, France.; Differentiation of naive CD4+ lymphocytes into either Th1 or Th2 cells is influenced by the cytokine present during initial antigen priming. IL-4 is the critical element in the induction of Th2 response; however, its origin during a primary immune response is not well-defined. Here, a novel source of IL-4, the class I
Differences in the glycosylation of recombinant and native human milk bile salt-stimulated lipase revealed by peptide mapping.: J Chromatogr A. 1995 Dec 1;718(1):53-8. Unique Identifier : AIDSLINE MED/96129766; Stromqvist M; Lindgren K; Hansson L; Juneblad K; ASTRA HASSLE AB, Umea, Sweden.; The milk of some mammals contains a bile salt-stimulated lipase (BSSL). Human milk BSSL is heavily glycosylated (30-40% carbohydrate) and present at a concentration of approximately 100-200 mg/l, thereby being one of the most abundant human whey proteins. BSSL has been shown to have an important role in the uptake of
A randomized, double-blind, placebo-controlled, dose-ranging study of dofetilide in patients with inducible sustained ventricular tachyarrhythmias.: J Cardiovasc Electrophysiol. 1995 Sep;6(9):687-99. Unique Identifier : AIDSLINE MED/96098524; Echt DS; Lee JT; Murray KT; Vorperian V; Borganelli SM; Crawford DM; Friedrich T; Roden DM; Department of Medicine, Vanderbilt University School of Medicine,; Nashville, Tennessee, USA.; INTRODUCTION: Dofetilide is a new antiarrhythmic agent with potent IK blocking properties in vitro. We developed a dose-ranging, placebo-controlled study design to define the range of effective doses and to evaluate the clinical electrophysiology of intravenous dofetilide in patients in whom sustained ventricular tach
Selective effects of DNA damaging agents on HIV long terminal repeat activation and virus replication in vitro.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):109-16. Unique Identifier : AIDSLINE MED/96147310; Manome Y; Yao XJ; Kufe DW; Cohen EA; Fine HA; Division of Cancer Pharmacology, Dana Farber Cancer Institute,; Harvard Medical School, Boston, Massachusetts 02115, USA.; Much attention has recently focused on the observation that UV light can activate the long terminal repeat (LTR) of the human immunodeficiency virus (HIV). Although the mechanism of LTR activation remains obscure, several lines of investigation have suggested that it is a result of activation of the NF-kappa B transcr
Zidovudine kinetics in the pregnant baboon.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):117-27. Unique Identifier : AIDSLINE MED/96147311; Garland M; Szeto HH; Daniel SS; Tropper PJ; Myers MM; Stark RI; College of Physicians and Surgeons, Columbia University, New; York, NY 10032, USA.; The devastating impact of human immunodeficiency virus (HIV) infection during pregnancy has made the pharmacologic evaluation of potentially therapeutic agents of high priority. The results presented here are the maternal pharmacokinetics from a series of experiments to delineate more clearly the complex maternal-feta
CD4+ T-lymphocyte lines developed from HIV-1-seropositive patients recognize different epitopes within the V3 loop.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):128-36. Unique Identifier : AIDSLINE MED/96147312; Ratto S; Sitz KV; Scherer AM; Loomis LD; Cox JH; Redfield RR; Birx DL; Henry M. Jackson Foundation, Rockville, MD 20850, USA.; To define the epitopes present within the V3 loop sequence recognized by five HIV-1 envelope-specific T-cell lines, a panel of V3 LAI peptides bearing sequential truncations from both the N- and C-terminus was synthesized and tested for their ability to induce proliferation. Each individual T-cell line had a different
L-cycloserine, an inhibitor of sphingolipid biosynthesis, inhibits HIV-1 cytopathic effects, replication, and infectivity.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):137-41. Unique Identifier : AIDSLINE MED/96147313; Mizrachi Y; Lev M; Harish Z; Sundaram SK; Rubinstein A; Department of Pediatrics, Microbiology and Immunology, Albert; Einstein College of Medicine, Bronx, NY 10461, USA.; Drugs that reduce viral production or prevent viral spread by interference with the host s cellular components are unlikely to induce resistance, in contrast to treatment modalities that interact with the HIV-1 life cycle. Two features make L-cycloserine (L-CS) a candidate drug of this kind: (a) L-CS is a potent inhib
Long-term follow-up of symptomatic HIV-infected patients originally randomized to early versus later zidovudine treatment; report of a Veterans Affairs Cooperative Study. VA Cooperative Study Group on AIDS Treatment.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):142-50. Unique Identifier : AIDSLINE MED/96147314; Simberkoff MS; Hartigan PM; Hamilton JD; Day PL; Diamond GR; Dickinson GM; Drusano GL; Egorin MJ; George WL; Gordin FM; Hawkes CA; Jensen PC; Kilmas NG; Labriola AM; O'Brien WA; Oster CN; Weinhold KJ; Wray NP; Pazner SB; Department of Veterans Affairs Medical Centers, New York, New; York, Baltimore, Maryland, USA.; Following a 4-year controlled trial comparing early and later zidovudine treatment, we conducted an additional 3-year follow-up. Of the original 338 patients, 275 participated. Clinical outcome measures were AIDS and death. In the early therapy group (n = 170), 67 patients progressed to AIDS compared with 85 in the la
Decisions to get HIV tested and to accept antiretroviral therapies among gay/bisexual men: implications for secondary prevention efforts.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):151-60. Unique Identifier : AIDSLINE MED/96147315; Stall R; Hoff C; Coates TJ; Paul J; Phillips KA; Ekstrand M; Kegeles S; Catania J; Daigle D; Diaz R; Center for AIDS Prevention Studies, University of California, San; Francisco 94143, USA.; The objective of this study was to report prevalence rates of adherence by HIV-seropositive individuals to medical recommendations for the treatment of HIV infection, a behavioral pattern referred to as AIDS secondary prevention. We report cross-sectional data (n = 2,593) from two household-based and two bar-based sam
Response of CD4 lymphocytes and clinical consequences of treatment using ddI or ddC in patients with advanced HIV infection.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):161-9. Unique Identifier : AIDSLINE MED/96147316; Goldman AI; Carlin BP; Crane LR; Launer C; Korvick JA; Deyton L; Abrams DI; Division of Biostatistics, School of Public Health, University of; Minnesota, Minneapolis 55455-0392, USA.; The value of CD4 lymphocyte counts as a surrogate marker in persons with advanced human immunodeficiency virus infection during antiretroviral treatment was assessed using longitudinal models and data from the Terry Beirn Community Programs for Clinical Research on AIDS didanosine/zalcitabine trial of 467 HIV-infected
Liver biopsy findings in 501 patients infected with human immunodeficiency virus (HIV).: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):170-7. Unique Identifier : AIDSLINE MED/96147317; Poles MA; Dieterich DT; Schwarz ED; Weinshel EH; Lew EA; Lew R; Scholes JV; New York University Medical Center, NY 10016, USA.; Patients infected with human immunodeficiency virus (HIV) are at risk for a variety of liver diseases. We undertook a retrospective study of 501 HIV-seropositive patients to assess the yield of percutaneous liver biopsy. The most common indications for liver biopsy were liver test abnormalities (89.5%), fever for 2 we
Marital status in relation to Kaposi's sarcoma, non-Hodgkin's lymphoma, and anal cancer in the pre-AIDS era.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):178-82. Unique Identifier : AIDSLINE MED/96147318; Biggar RJ; Melbye M; Viral Epidemiology Branch, National Cancer Institute, Bethesda,; Maryland, USA.; Persons with human immunodeficiency virus/AIDS are at high risk of Kaposi s sarcoma (KS), non-Hodgkin lymphoma (NHL), and possibly anal cancers. To examine whether this risk preceded the AIDS epidemic, we used pre-AIDS era data from the Surveillance, Epidemiology, and End Results program (excluding Connecticut) from 1
High rates of sexual contact with female sex workers, sexually transmitted diseases, and condom neglect among HIV-infected and uninfected men with tuberculosis in Abidjan, Cote d'Ivoire.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):183-7. Unique Identifier : AIDSLINE MED/96147319; Sassan-Morokro M; Greenberg AE; Coulibaly IM; Coulibaly D; Sidibe K; Ackah A; Tossou O; Gnaore E; Wiktor SZ; De Cock KM; Project RETRO-CI, Abidjan, Cote d'Ivoire.; To characterize human immunodeficiency virus (HIV) risk practices among men with tuberculosis, and to determine what factors are associated with HIV infection in this population, we conducted a case-control analysis of data collected during enrollment in a prospective cohort study in the two large tuberculosis treatme
Changes in membrane enzymes and glycosphingolipids in lymphocytes from HIV-1--infected and noninfected intravenous drug users.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):188-97. Unique Identifier : AIDSLINE MED/96147320; Leoni LM; Losa GA; Laboratory of Cellular Pathology, Institute of Pathology,; Locarno, Switzerland.; The amounts of cell-surface glycosphingolipids and plasma membrane enzymes produced on the peripheral blood mononuclear cells (PBMNCs) isolated from 101 intravenous drug users (IDUs), of whom 91 were HIV-1 seropositive, were examined. Seronegative IDUs and age-matched healthy donors served as controls. The numbers of
Psychological dysfunction and HIV/AIDS risk behavior.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):198-202. Unique Identifier : AIDSLINE MED/96147321; Camacho LM; Brown BS; Simpson DD; Institute of Behavioral Research, Texas Christian University,; Forth Worth 76129, USA.; The relationship between psychological problems and human immunodeficiency virus HIV/AIDS risk-taking behaviors was examined among 834 daily opioid users entering methadone treatment programs. A composite measure of psychological dysfunction was created using depression, anxiety, and hostility scales. This measure was
Role of primary infection in epidemics of HIV in gay cohorts [letter; comment]: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):204. Unique Identifier : AIDSLINE MED/96147323; Ahlgren DJ
p24 antigenemia in African patients during primary HIV infection [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):204-5. Unique Identifier : AIDSLINE MED/96147324; Simon F; Descamps D; Boucheaud O; Lacassin F; Bedos JP; Dussaix E; Brun-Vezinet F
Using HIV/AIDS surveillance to monitor public health efforts to reduce perinatal transmission of HIV [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):205-6. Unique Identifier : AIDSLINE MED/96147325; Wortley PM; Fleming PL; Lindegren ML; Sweeney PA; Davis S
14-year follow-up of HIV-infected homosexual men with lymphadenopathy syndrome [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):206-8. Unique Identifier : AIDSLINE MED/96147326; Kaplan JE; Spira TJ; Fishbein DB; Lyn HS
HIV seroprevalence study among 729 female prostitutes in Italy [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Feb 1;11(2):208-9. Unique Identifier : AIDSLINE MED/96147327; Tirelli U; Spina M; Mancuso S; Traina C; Sinicco A
[Withdrawal in opiate addicts in an internal medicine hospital unit]: Bull Acad Natl Med. 1995 Oct;179(7):1335-51; discussion 1351-4. Unique Identifier : AIDSLINE MED/96151625; Cremer GA; Boissonnas A; Service de Medecine Interne, Groupe hospitalier Cochin, Paris.; Withdrawal of opiates drug addicts in Internal Medicine is unusual in France . Four main preliminary conditions are requested: 1--Drug addict preparation and self motivation, 2--Inter and intra institution team collaboration, 3--Opening the hospital towards community agencies, 4--Ho
Markers of hepatitis C and B virus infections among blood donors in Ho Chi Minh City and Hanoi, Vietnam.: Clin Diagn Lab Immunol. 1994 Jul;1(4):413-8. Unique Identifier : AIDSLINE MED/96050848; Song P; Duc DD; Hien B; Nakata S; Chosa T; Watanabe J; Tsuda F; Murata K; Okamoto H; Institute for Clinical Research in Tropical Medicine, Bach Mai; Hospital, Hanoi, Vietnam.; Blood donors in two cities in Vietnam were tested for markers of hepatitis C virus (HCV) and hepatitis B virus infections. Antibody to HCV was detected by passive hemagglutination with antigens of the second generation in 101 (20.6%) of 491 donors in Ho Chi Minh City; it was detec
Antineurofilament and antiretinal antibodies in AIDS patients with cytomegalovirus retinitis.: Clin Diagn Lab Immunol. 1994 Jul;1(4):445-9. Unique Identifier : AIDSLINE MED/96050853; Rosberger DF; Tshering SL; Polsky B; Heinemann MH; Klein RF; Cunningham-Rundles S; Department of Ophthalmology, Cornell University Medical College,; New York, New York 10021, USA.; Sera obtained from AIDS patients with cytomegalovirus ( CMV ) retinitis before and after treatment with foscarnet, AIDS patients with human immunodeficiency virus (HIV) retinopathy, AIDS patients without retinal disease, and no
Inhibitory effect of 3'-azido-3'-deoxythymidine on proliferative responsiveness of CD8+ lymphocytes to interleukin-2.: Clin Diagn Lab Immunol. 1994 Jul;1(4):482-5. Unique Identifier : AIDSLINE MED/96050859; Mercure L; Lalonde R; Phaneuf D; Brenner B; Wainberg MA; McGill University AIDS Centre, Montreal, Quebec, Canada.; Although several studies have shown that 3 -azido-3 -deoxythymidine ( AZT ) is not toxic for CD4+ lymphocytes, its effect on CD8+ cells has never been studied in a systematic way. We purified CD8+ cells from the peripheral blood mononuclear cells of bot
Monokine-mediated increase in human immunodeficiency virus type 1 expression in chronically infected promonocyte- and T-cell-derived lines.: Clin Diagn Lab Immunol. 1994 Sep;1(5):517-25. Unique Identifier : AIDSLINE MED/96050865; Ho WZ; Tomassini N; Cherukuri R; Shun-D G; Song L; Lee HR; Douglas SD; Department of Pediatrics, Children's Hospital of Philadelphia,; University of Pennsylvania Medical School 19104, USA.; The ACH-2 cell clone derived from a human T-cell line and chronically infected with human immunodeficiency virus 1 (HIV-1) and the U1 cell clone derived from a human promonocyte cell line and also chronically infected with HIV-1 produce HIV-1 in a response to stimulation with monokine-enriched supernatants prepared fr
Blood monocytes from most human immunodeficiency virus type 1-infected patients do not carry proviral DNA.: Clin Diagn Lab Immunol. 1994 Sep;1(5):531-7. Unique Identifier : AIDSLINE MED/96050867; Shen Y; Rudnik J; Cassol S; Drouin J; Cameron W; Izaguirre CA; Filion LG; Department of Microbiology, University of Ottawa General; Hospital, Ontario, Canada.; In blood, the CD4+ T cells of patients with human immunodeficiency virus type 1 (HIV-1) harbor HIV-1; however, whether the CD4+ blood monocytes carry the virus is controversial. Tissue macrophages are known to be infected. To determine in blood monocytes from HIV-1-seropositive patients contain HIV-1, we separated mon
Interleukin-2-inducible natural immune (lymphokine-activated killer cell) responses as a functional correlate of progression to AIDS.: Clin Diagn Lab Immunol. 1994 Sep;1(5):538-44. Unique Identifier : AIDSLINE MED/96050868; Brenner BG; Gornitsky M; Wainberg MA; McGill AIDS Centre, Lady Davis Institute--Jewish General; Hospital, Montreal, Quebec, Canada.; The functions of natural killer (NK) cells and their interleukin-2-deducible counterparts, lymphokine-activated killer (LAK) cells, are often impaired in human immunodeficiency virus (HIV)-infected individuals. A statistical approach was used to establish if changes in LAK activity were associated with antiviral drug
Characterization of circulating CD4+ CD8+ lymphocytes in healthy individuals prompted by identification of a blood donor with a markedly elevated level of CD4+ CD8+ lymphocytes.: Clin Diagn Lab Immunol. 1994 Sep;1(5):597-605. Unique Identifier : AIDSLINE MED/96050877; Prince HE; Golding J; York J; Cellular Immunology Laboratory, American Red Cross Blood and; Tissue Services, Southern California Region, Los Angeles, USA.; During flow cytometric analysis of lymphocytes from healthy donors, we identified a donor (donor A) with 22% CD4+ CD8+ cells (versus values of
Rapid culture and quantitation of human immunodeficiency virus type 1 from patient cells without the use of mitogen-stimulated donor cells.: Clin Diagn Lab Immunol. 1994 Nov;1(6):660-6. Unique Identifier : AIDSLINE MED/96050887; Kim PK; He S; HO JL; Division of International Medicine, Cornell University Medical; College, New York, New York 10021, USA.; We report the development of a rapid, sensitive virus culture method for direct quantitation of human immunodeficiency virus (HIV) in peripheral blood mononuclear cells (PBMCs). This new method involves culturing 10(7) PBMCs from HIV-seropositive persons in 10 ml of medium containing phorbol 12-myristate 13-acetate an
Major antigenic region on the integrase (IN) protein of human immunodeficiency virus type 1 determined by reactivity of human sera and a monoclonal antibody to IN protein.: Clin Diagn Lab Immunol. 1994 Nov;1(6):678-83. Unique Identifier : AIDSLINE MED/96050890; Tachibana Y; Yasuda A; Kurata T; Oka S; Shimada K; Kojima A; Department of Pathology, National Institute of Health, Tokyo,; Japan.; The gene encoding the integrase (IN) protein of human immunodeficiency virus type 1 (HIV-1) was expressed in vaccinia virus and Escherichia coli, and sera from 55 HIV-1-infected individuals were examined for immunoreactivity to the recombinant IN proteins by Western immunoblot. Approximately 98% (54 of 55) of the HIV-
The prevalence of HIV-1 infection among inmates in Ontario, Canada.: Can J Public Health. 1995 Sep-Oct;86(5):335-9. Unique Identifier : AIDSLINE MED/96114373; Calzavara LM; Major C; Myers T; Schlossberg J; Millson M; Wallace E; Rankin J; Fearon M; HIV Social, Behavioural and Epidemiological Studies Unit, Faculty; of Medicine, University of Toronto, ON.
Neuropsychiatric HIV-1 infection study: in Kenya and Zaire cross-sectional phase I and II.: Cent Afr J Med. 1995 Oct;41(10):315-22. Unique Identifier : AIDSLINE MED/96137271; Sebit MB; Department of Psychiatry, University of Zimbabwe, Avondale,; Harare, Zimbabwe.; The objective of the study was to determine the prevalence and natural history of human immunodeficiency virus type 1 (HIV-1) associated psychiatric, neuropsychological and neurological abnormalities. A total of 408 subjects were recruited in Nairobi and Kinshasa. The study consisted of a cross sectional phase and a l
Kaposi's sarcoma in a two week old infant born to a mother with Kaposi's sarcoma/AIDS.: Cent Afr J Med. 1995 Oct;41(10):330-1. Unique Identifier : AIDSLINE MED/96137275; McCarty KA; Bungu Z; Chidamoyo Christian Hospital, Karoi, Zimbabwe.
Measurement of apoptotic cells in peripheral blood.: Cytometry. 1995 Sep 15;22(3):161-7. Unique Identifier : AIDSLINE MED/96106598; Carbonari M; Cibati M; Fiorilli M; Department of Clinical Medicine, University of Rome La Sapienza,; Italy.; The measurement of apoptosis in peripheral blood might represent a useful tool in acquired immunodeficiency syndrome (AIDS) and cancer research. Among the many assays that are currently used to identify apoptotic leukocytes, flow cytometric methods are the most valuable in terms of rapidity, simplicity, and level of a
Standardization of absolute CD4+ lymphocyte counts across laboratories: an evaluation of the Ortho CytoronAbsolute flow cytometry system on normal donors.: Cytometry. 1995 Sep 15;22(3):200-10. Unique Identifier : AIDSLINE MED/96106603; Connelly MC; Knight M; Giorgi JV; Kagan J; Landay AL; Parker JW; Page E; Spino C; Wilkening C; Mercolino TJ; Immunocytometry Research and Development, Ortho Diagnostic; Systems, Raritan, New Jersey 08869, USA.; The Ortho CytoronAbsolute is a flow cytometer designed to provide direct absolute counts of lymphocytes and their subsets from a single instrument. This study was designed to determine the performance of four geographically separated CytoronAbsolute instruments using 24-h-old, shipped, whole blood samples and to compa
Peripheral gamma delta T-cell populations in HIV-infected individuals with mycobacterial infection.: Cytometry. 1995 Sep 15;22(3):211-6. Unique Identifier : AIDSLINE MED/96106604; Ruiz P; Geraldino N; Department of Pathology, University of Miami School of Medicine,; Florida.; Previous studies have suggested that gamma delta T cells can be increased in HIV-1-seropositive individuals, although characterization of gamma delta T cell subtypes and correlation with clinical status of these patients have not been performed. We investigated groups of HIV-seropositive persons to determine the preva
CD43 and CD5 antibodies define four normal and neoplastic B-cell subsets: a three-color flow cytometric study.: Cytometry. 1995 Sep 15;22(3):223-31. Unique Identifier : AIDSLINE MED/96106606; Lynch EF; Jones PA; Swerdlow SH; Department of Pathology, University of Pittsburgh School of; Medicine, Pennsylvania, USA.; CD43 antibodies are best known for identifying normal and neoplastic T cells and a subset of neoplastic B cells in paraffin sections. The frequency of nonneoplastic CD43 + B cells in different reactive settings, the proportion of B-cell neoplasms with small CD43+ populations, and the relationship of CD43+ B cells was
Are there differences between laboratories that use or fail to use the CDC's guidelines to measure CD4+ and CD8+ T cells? [letter]: Cytometry. 1995 Sep 15;22(3):256-7. Unique Identifier : AIDSLINE MED/96106610; Ferbas J; Logar AJ
Patterns of injecting and sharing in a Scottish prison.: Drug Alcohol Depend. 1995 Oct;39(3):237-43. Unique Identifier : AIDSLINE MED/96127545; Shewan D; Macpherson A; Reid MM; Davies JB; Department of Psychology, Glasgow Caledonian University, UK.; Although the potential for prisons to act as the setting for HIV transmission has been recognised, there is an enduring lack of knowledge in this area. Data are presented on patterns of injecting and sharing in Edinburgh prison (Scotland), 1993-1994. There was a relatively low level of injecting in Edinburgh prison du
Inactivation of HIV-1 by chemical disinfectants: sodium hypochlorite.: Epidemiol Infect. 1995 Dec;115(3):567-79. Unique Identifier : AIDSLINE MED/96150221; Van Bueren J; Simpson RA; Salman H; Farrelly HD; Cookson BD; Laboratory of Hospital Infection, Central Public Health; Laboratory, London, UK.; The efficacy of sodium hypochlorite was assessed against human immunodeficiency virus type 1 suspended in low (8% v/v) or high (80% v/v) concentrations of serum or in a high (80%) concentration of blood. In the presence of 8% serum, 100 p.p.m. available chlorine in the disinfectant test mixture inactivated 3.75 log TC
NF-kappa B-mediated chromatin reconfiguration and transcriptional activation of the HIV-1 enhancer in vitro.: Genes Dev. 1996 Jan 1;10(1):37-49. Unique Identifier : AIDSLINE MED/96136707; Pazin MJ; Sheridan PL; Cannon K; Cao Z; Keck JG; Kadonaga JT; Jones KA; Department of Biology, University of California, San Diego; (UCSD), La Jolla 92093-0347, USA.; NF-kappa B is a potent inducible transcription factor that regulates many genes in activated T cells. In this report we examined the ability of different subunits of NF-kappa B to enhance HIV-1 transcription in vitro with chromatin templates. We find that the p65 subunit of NF-kappa B is a strong transcriptional activ
Human papillomavirus is associated with the frequent detection of warty and basaloid high-grade neoplasia of the vulva and cervical neoplasia among immunocompromised women.: Gynecol Oncol. 1996 Jan;60(1):30-4. Unique Identifier : AIDSLINE MED/96139371; Petry KU; Kochel H; Bode U; Schedel I; Niesert S; Glaubitz M; Maschek H; Kuhnle H; Department of Gynecological Oncology, University of Hannover,; Germany.; A total of 158 women who either HIV-infected or under iatrogenic immunosuppression were examined regularly during a 4-year period to evaluate if certain vulvar neoplasms and cervical neoplasia have similar associated risk factors. Patients with CIN were matched prospectively with immunocompetent controls with CIN. For
Multiple host defense defects in failure of C57BL/6 ep/ep (pale ear) mice to resolve visceral Leishmania donovani infection.: Infect Immun. 1996 Jan;64(1):161-6. Unique Identifier : AIDSLINE MED/96110929; Murray HW; Hariprashad J; McDermott DF; Stoeckle MY; Department of Medicine, Cornell University Medical College, New; York, New York 10021, USA.; Euthymic C57BL/L ep/ep (pale ear [PE]) mice halt the visceral replication of intracellular Leishmania donovani but fail to properly resolve infection. A previous study identified an isolated defect in tissue granuloma formation in these mice; CD4+ and CD8+ cell number, gamma interferon (IFN-gamma) production, and macr
Human CD4+ and CD8+ T lymphocytes are both cytotoxic to Toxoplasma gondii-infected cells.: Infect Immun. 1996 Jan;64(1):176-81. Unique Identifier : AIDSLINE MED/96110931; Montoya JG; Lowe KE; Clayberger C; Moody D; Do D; Remington JS; Talib S; Subauste CS; Department of Immunology and Infectious Diseases, Palo Alto; Medical Foundation, California 94301, USA.; Studies to determine if Toxoplasma gondii-specific human T cells lyse parasite-infected cells have yielded conflicting results. Furthermore, attempts to obtain human cytotoxic CD8+ T lymphocytes have been difficult because of the lack of a reproducible system for their generation. By using paraformaldehyde-fixed, T. g
Antigenic differences associated with genetically distinct Pneumocystis carinii from rats.: Infect Immun. 1996 Jan;64(1):290-7. Unique Identifier : AIDSLINE MED/96110946; Vasquez J; Smulian AG; Linke MJ; Cushion MT; Department of Internal Medicine, James Quillen College of; Medicine, Johnson City, Tennessee 37614-0622, USA.; Pneumocystis carinii is a family of organisms found in a wide variety of mammalian lungs. In immunocompromised hosts, the organisms are able to produce an oftentimes fatal pneumonia. The existence of distinct types of Pneumocystis populations is strongly supported by antigenic and genetic evidence. In the present stud
Complete development of Cryptosporidium parvum in bovine fallopian tube epithelial cells.: Infect Immun. 1996 Jan;64(1):349-54. Unique Identifier : AIDSLINE MED/96110955; Yang S; Healey MC; Du C; Zhang J; Department of Animal, Dairy and Veterinary Sciences, Utah State; University, Logan 84322-5600, USA.; Cryptosporidium parvum is a coccidian parasite responsible for causing protracted and life-threatening diarrheal illness in immunocompromised humans, especially patients with AIDS. The lack of medications effective in treating people suffering from cryptosporidiosis has prompted the development of in vivo and in vitro
Reconstitution of B-cell-depleted mice with B cells restores Th2-type immune responses during Plasmodium chabaudi chabaudi infection.: Infect Immun. 1996 Jan;64(1):366-70. Unique Identifier : AIDSLINE MED/96110959; Taylor-Robinson AW; Phillips RS; Wellcome Laboratories for Experimental Parasitology, University; of Glasgow, United Kingdom.; In mice depleted of B cells from birth by treatment with anti-immunoglobulin M(mu) antibodies, progression from a Th1- to a Th2-regulated immune response during primary infection with Plasmodium chabaudi chabaudi fails to occur. While Th1-type immunity limits parasitemia, in the absence of B cells, chronic low-grade i
Predicting in-hospital outcome in HIV-associated Pneumocystis carinii pneumonia.: Infection. 1995 Sep-Oct;23(5):272-7. Unique Identifier : AIDSLINE MED/96128586; Bauer T; Ewig S; Hasper E; Rockstroh JK; Luderitz B; Berufsgenossenschaftliche Kliniken Bergmannsheil, Abt. f.; Pneumologie u. Allergologie, Bochum, Germany.; Pneumocystis carinii pneumonia (PCP) in HIV-infected patients remains a life-threatening complication in the course of HIV infection. Despite effective treatment, mortality may still be as high as 10%. The identification of risk factors associated with a lethal outcome might be helpful as a guide to therapy for patien
Cerebrospinal fluid antiganglioside antibodies in patients with AIDS.: Infection. 1995 Sep-Oct;23(5):288-91. Unique Identifier : AIDSLINE MED/96128589; Sorice M; Griggi T; Circella A; Nicodemo G; Ciardi M; Mastroianni CM; Lenti L; Sorice F; Dip. Malattie Infettive e Tropicali, Universita La Sapienza,; Rome, Italy.; In this study the presence of brain antiganglioside antibodies in the cerebrospinal fluid (CSF) of patients with HIV infection was analysed. CSF samples were collected from 45 patients with AIDS and from 45 anti-HIV negative subjects, 15 of whom presented aseptic meningitis. Nineteen AIDS patients had clinically well-
First case of disseminated Mycobacterium avium infection following chemotherapy for childhood acute myeloid leukemia.: Infection. 1995 Sep-Oct;23(5):301-2. Unique Identifier : AIDSLINE MED/96128592; Claass A; Claviez A; Westphal E; Rusch-Gerdes S; Schneppenheim R; Institut fur Immunologie, Christian-Albrechts-Universitat,; Kiel, Germany.; A 14-year-old girl of Indian origin with acute myeloid leukemia (AML) is presented, who was diagnosed at the age of twelve. Antileukemic chemotherapy had to be discontinued after 6 weeks because of persistent high fever and the emergence of liver and spleen abscesses. Serologic and biopsy findings were consistent with
Bordetella bronchiseptica pneumonia in an AIDS patient: a new opportunistic infection [letter]: Infection. 1995 Sep-Oct;23(5):312-3. Unique Identifier : AIDSLINE MED/96128597; Libanore M; Rossi MR; Pantaleoni M; Bicocchi R; Carradori S; Sighinolfi L; Ghinelli F
Munchhausen's syndrome in an HIV-sero-indeterminate patient [letter]: Infection. 1995 Sep-Oct;23(5):315. Unique Identifier : AIDSLINE MED/96128599; Caron F; Young P; Villeneuve H; Mendel I; Pestel M; Gueit I; Lecomte F; Humbert G
Multicentre study for diagnostic evaluation of an assay for simultaneous detection of antibodies to HIV-1, HIV-2 and HIV-1 subtype 0 (HIV-0).: Infection. 1995 Sep-Oct;23(5):322-33. Unique Identifier : AIDSLINE MED/96128601; Bachmann P; Beyer J; Brust S; Engelhardt W; Gurtler LG; Habermehl KO; Karakassopoulos A; Michl U; Muhlbacher A; Stoffler-Meilicke M; et al; Swiss Red Cross, Central Laboratory, Bern, Switzerland.; The aim of the study was to evaluate a new ELISA for detection of HIV-1, HIV-2 and HIV-1 subtype 0 (HIV-0) antibodies. The assay format is based on the antigen sandwich principle. To enable specific detection of HIV-0 antibodies, in addition to HIV-1 and HIV-2 antigens HIV-0 antigen is used for coating the solid phase
Syringe exchange: HIV prevention, key findings, and future directions.: Int J Addict. 1995;30(12):1647-83. Unique Identifier : AIDSLINE MED/96122207; Paone D; Des Jarlais DC; Gangloff R; Milliken J; Friedman SR; Beth Israel Medical Center, Chemical Dependency Institute, New; York, NY 10003, USA.; HIV among injecting drug users (IDUs) has now been documented in over 60 countries in the world, and there are an additional 40 countries where injecting drug use has been reported including widespread epidemics in Southeast and southern Asia and in Latin America. At present HIV infection is almost always fatal, and t
The effect of human immunodeficiency virus infection on birthweight, and infant and child mortality in urban Malawi.: Int J Epidemiol. 1995 Oct;24(5):1022-9. Unique Identifier : AIDSLINE MED/96128733; Taha TE; Dallabetta GA; Canner JK; Chiphangwi JD; Liomba G; Hoover DR; Miotti PG; Department of Epidemiology, Johns Hopkins University School of; Hygiene and Public Health, Baltimore, MD 21205, USA.; BACKGROUND. Low birthweight, prematurity and intra-uterine growth retardation (IUGR) are major determinants of child survival. Therefore, it is important to assess excess mortality due to human immunodeficiency virus (HIV) infection in populations where low birthweight is common. METHODS. A prospective study was condu
Prevalence of HIV-1 infection in 18 year old men in Tuscany. The Toscana Collaborative Group.: Int J Epidemiol. 1995 Oct;24(5):1030-3. Unique Identifier : AIDSLINE MED/96128734; Mazzotta F; Di Pietro M; Balocchini E; Paci P; Galanti C; Abeni DD; Perucci CA; Divisione di Malattie Infettive, Ospedale S M Annunziata,; Firenze, Italy.; BACKGROUND. The main route of transmission of the human immunodeficiency virus type 1 (HIV-1) is sexual contact. A high proportion of young adults is exposed to this mode of transmission. Therefore it is important to assess the level of HIV-1 prevalence among 18 year olds in Italy .
Dietary determinants of a non-progressive spastic paraparesis (Konzo): a case-referent study in a high incidence area of Zaire.: Int J Epidemiol. 1995 Oct;24(5):949-56. Unique Identifier : AIDSLINE MED/96128723; Tylleskar T; Banea M; Bikangi N; Nahimana G; Persson LA; Rosling H; Department of Pediatrics, University Hospital, Uppsala, Sweden.; BACKGROUND. Konzo is an upper motor neuron disease in Africa, characterized by an abrupt onset of a permanent but non-progressive spastic paraparesis. It is named after the local designation in the first report from Zaire . Konzo has been attributed to a metabolic insult from the c
Effect of phosphodiesterase inhibition on IL-4 and IL-5 production of the murine TH2-type T cell clone D10.G4.1.: Immunopharmacology. 1995 Sep;30(3):191-8. Unique Identifier : AIDSLINE MED/96128551; Schmidt J; Hatzelmann A; Fleissner S; Heimann-Weitschat I; Lindstaedt R; Szelenyi I; ASTA Medica AG, Department of Pharmacology, Frankfurt/Main,; Germany.; The effect of various phosphodiesterase (PDE) inhibitors on anti-CD3 induced interleukin-(IL)-4 and IL-5 production of the murine T helper cell clone of type 2 phenotype D10.G4.1 (D10) has been investigated in vitro. D10 cells were incubated in the presence of drugs and anti-CD3 mAb for 16 h before measurement of cyto
Effects of isoniazid treatment on human lymphocyte proliferative response, lymphocyte subsets and natural killer cell activity.: Immunopharmacology. 1995 Sep;30(3):247-53. Unique Identifier : AIDSLINE MED/96128558; Ravn P; Linnet J; Klokker M; Pedersen BK; Department of Infectious Diseases, Rigshospitalet, Copenhagen,; Denmark.; The effect of isoniazid on proliferative response, natural killer (NK) cell activity and lymphocyte subset distribution of blood mononuclear cells (BMNC) was investigated. To evaluate the effect of treatment with isoniazid in pharmacologic concentrations, twenty healthy HIV-seronegative volunteers were randomized into
PCR in situ: aspects which reduce amplification and generate false-positive results.: Histochem J. 1995 Sep;27(9):660-9. Unique Identifier : AIDSLINE MED/96121506; Teo IA; Shaunak S; Department of Infectious Diseases, Royal Postgraduate Medical; School, London, UK.; PCR in situ promises the ability to amplify and detect very low levels of target nucleic acid in tissues. Despite considerable effort, the technique is still technically difficult and has not yet proved to be reliable or reproducible. We have now identified a number of factors which can contribute to the poor amplific
Reexamination of the paradigm of HIV risk reduction in adolescents.: J Am Osteopath Assoc. 1995 Dec;95(12):725-8. Unique Identifier : AIDSLINE MED/96148238; Earl DT; Department of Family Medicine, East Tennessee State University,; James H. Quillen College of Medicine, Johnson City, TN 37604,; USA.; Infection with the human immunodeficiency virus (HIV) in the adolescent/young adult population of the United States is a serious, growing problem. The current HIV risk-reduction strategies for adolescents have been less than effective in stemming the tide of infection. This ineffective
Eulicin inhibits human immunodeficiency virus infection and replication.: J Antibiot (Tokyo). 1995 Nov;48(11):1362-3. Unique Identifier : AIDSLINE MED/96139408; Nakamura M; Yoshida K; Yoshida M; Kunimoto S; Takeuchi T; Ohno T; Department of Microbiology, Jikei University School of Medicine,; Tokyo, Japan.
Siamycins I and II, new anti-HIV-1 peptides: II. Sequence analysis and structure determination of siamycin I.: J Antibiot (Tokyo). 1995 Dec;48(12):1515-7. Unique Identifier : AIDSLINE MED/96139438; Detlefsen DJ; Hill SE; Volk KJ; Klohr SE; Tsunakawa M; Furumai T; Lin PF; Nishio M; Kawano K; Oki T; et al; Bristol-Myers Squibb Pharmaceutical Research Institute,; Wallingford, CT 06492, USA.
Signal transduction pathway of interleukin-4 and interleukin-13 in human B cells derived from X-linked severe combined immunodeficiency patients.: J Biol Chem. 1996 Jan 12;271(2):619-22. Unique Identifier : AIDSLINE MED/96132783; Izuhara K; Heike T; Otsuka T; Yamaoka K; Mayumi M; Imamura T; Niho Y; Harada N; Department of Human Genetics, National Institute of Genetics,; Shizuoka, Japan.; Interleukin-4 (IL-4) and IL-13 are functionally similar cytokines. The functional IL-4 receptor (IL-4R) consists of the IL-4R alpha chain (IL-4R alpha) and the IL-2R gamma chain (gamma c), which is shared by the IL-2, IL-7, IL-9, and IL-15 receptors. The functional IL-13R is thought to involve the IL-4R alpha but not
Steps toward gene therapy: 1. The initial trials.: Hosp Pract (Off Ed). 1995 Nov 15;30(11):33-40. Unique Identifier : AIDSLINE MED/96110745; Blaese RM; Clinical Gene Therapy Branch, National Center for Human Genome; Research, National Institutes of Health, Bethesda, Md., USA.; Hopes for correcting the instruction tape in patients with genetic disease are being intensively explored. Initial efforts centered on monogenic immunodeficiency states, but in a pattern not wholly expected by researchers, the acquired genetic diseases of cancer and AIDS account for most ongoing clinical trials. Exper
Limited T cell receptor usage by HTLV-I tax-specific, HLA class I restricted cytotoxic T lymphocytes from patients with HTLV-I associated neurological disease.: J Neuroimmunol. 1995 Dec;63(1):47-53. Unique Identifier : AIDSLINE MED/96110770; Elovaara I; Utz U; Smith S; Jacobson S; Department of Neurology, Tampere University Hospital, Finland.; T cell receptor (TCR) V alpha and V beta chain usage of HTLV-I tax-specific, HLA class I restricted CD8+ cytotoxic T cells (CTL) was determined from lymphocytes obtained from peripheral blood of patients with HTLV-I associated neurological disease. To characterize TCR repertoire, CD8+ lymphocytes from peripheral blood
Position of the American Dietetic Association: oral health and nutrition.: J Am Diet Assoc. 1996 Feb;96(2):184-9. Unique Identifier : AIDSLINE MED/96160814
Abnormal thymocyte subset distribution and differential reduction of CD4+ and CD8+ T cell subsets during peripheral maturation in diabetes-prone BioBreeding rats.: J Immunol. 1996 Feb 1;156(3):1269-75. Unique Identifier : AIDSLINE MED/96144354; Groen H; Klatter FA; Brons NH; Mesander G; Nieuwenhuis P; Kampinga J; Department of Histology and Cell Biology, University of; Groningen, The Netherlands.; In this study we quantified CD8+ and CD4+ T cells in T lymphocytopenic BB rats as compared with control rats at given stages along the maturational pathway from immature thymocytes to mature peripheral T cells. Our results show that BB rats exhibit abnormal thymocyte subset distribution. Numbers of mature TCRhigh/CD4-
Adoptively transferred CD8+ T lymphocytes provide protection against TMEV-induced demyelinating disease in BALB/c mice.: J Immunol. 1996 Feb 1;156(3):1276-83. Unique Identifier : AIDSLINE MED/96144355; Nicholson SM; Dal Canto MC; Miller SD; Melvold RW; Department of Microbiology-Immunology, Northwestern University; Medical School, Chicago, IL 60611, USA.; On intracerebral infection with the BeAn strain of Theiler s murine encephalomyelitis virus (TMEV), certain mouse strains develop a chronic demyelinating disease similar both clinically and pathologically to human multiple sclerosis. Other strains remain resistant. We previously established that differential susceptib
Mechanisms for the transendothelial migration of HIV-1-infected monocytes into brain.: J Immunol. 1996 Feb 1;156(3):1284-95. Unique Identifier : AIDSLINE MED/96144356; Nottet HS; Persidsky Y; Sasseville VG; Nukuna AN; Bock P; Zhai QH; Sharer LR; McComb RD; Swindells S; Soderland C; Gendelman HE; Department of Pathology, Eppley Institute for Cancer and Allied; Disease, University of Nebraska Medical Center, Omaha 68198, USA.; HIV-1 penetration of the brain is a pivotal event in the neuropathogenesis of AIDS-associated dementia . The establishment of productive viral replication or up-regulation of adhesion molecule expression on brain microvascular endothelial cells (BMVEC) could permit entry of HIV into
HIV glycoprotein 120 enhances intercellular adhesion molecule-1 gene expression in glial cells. Involvement of Janus kinase/signal transducer and activator of transcription and protein kinase C signaling pathways.: J Immunol. 1996 Feb 1;156(3):1307-14. Unique Identifier : AIDSLINE MED/96144358; Shrikant P; Benos DJ; Tang LP; Benveniste EN; Department of Cell Biology, University of Alabama, Birmingham; 35294, USA.; It is well established that the two major glial cells in the central nervous system (CNS), astrocytes and microglia, are key participants in mediating the neurologic dysfunction associated with HIV infection of the CNS. In this study, we investigated the ability of the major envelope glycoprotein of HIV, glycoprotein
IL-12, as an adjuvant, promotes a T helper 1 cell, but does not suppress a T helper 2 cell recall response.: J Immunol. 1996 Feb 1;156(3):887-94. Unique Identifier : AIDSLINE MED/96144306; Bliss J; Van Cleave V; Murray K; Wiencis A; Ketchum M; Maylor R; Haire T; Resmini C; Abbas AK; Wolf SF; Genetics Institute Inc., Cambridge, MA 02140, USA.; IL-12 is a potent inducer of NK and cytolytic T cell activity, IFN-gamma production, and T cell proliferation, and is necessary for differentiation of naive T cells to the Th1 subset. We have previously shown that IL-12 promotes a primary Th1 response and suppresses a primary Th2 response in lymph nodes of mice primed
The role of BALB/c donor CD8+ lymphocytes in graft-versus-host disease in (BALB/c x A/J)F1 (CAF1) mice.: J Immunol. 1996 Feb 1;156(3):997-1005. Unique Identifier : AIDSLINE MED/96144319; Vidal S; Labrador M; Rodriguez-Sanchez JL; Gelpi C; Department of Immunology, Hospital de Sant Pau, Universitat; Autonoma de Barcelona, Avgda, Spain.; To investigate the role of donor T lymphocyte subsets in the development of chronic graft-vs-host disease (GVHD) induced in (BALB/c x A/J)F1 (CAF1) mice by injecting BALB/c lymphoid cells, we analyzed the effect that CD8+ cell removal from donor inoculum has on the manifestation of the disease. Compared with age- and
Further clinical studies of curdlan sulfate (CRDS)--an anti-HIV agent.: J Med. 1995;26(3-4):97-131. Unique Identifier : AIDSLINE MED/96098544; Gordon M; Guralnik M; Kaneko Y; Mimura T; Goodgame J; Lang W; Aji Pharma USA, Inc., Glenpointe Centre West, Teaneck, NJ 07666,; USA.; Curdlan sulfate (CRDS) is a semi-synthetic sulfated polysaccharide which inhibits the attachment of HIV to T-cells, and also has intracellular anti-HIV activity. In Phase I clinical trials, CRDS was found in 4 hr i.v. infusions, to be well tolerated up to 200 mg/70 kg and unexpectedly to produce marked, dose-related i
Essential role of NF-kappa B in transactivation of the human immunodeficiency virus long terminal repeat by the human cytomegalovirus 1E1 protein.: J Gen Virol. 1996 Jan;77 ( Pt 1):83-91. Unique Identifier : AIDSLINE MED/96145137; Kim S; Yu SS; Kim VN; Institute for Molecular Biology and Genetics, Seoul National; University, Kwan-Ak-Gu, Korea.; The 72 kDa 1E1 protein of human cytomegalovirus (HCMV) is one of a few viral regulatory proteins expressed immediately after infection of a host cell. Although it is now well-established that 1E1 is a potent transcriptional activator of the human immunodeficiency virus (HIV) long t
Comparative study of the cell tropism of feline immunodeficiency virus isolates of subtypes A, B and D classified on the basis of the env gene V3-V5 sequence.: J Gen Virol. 1996 Jan;77 ( Pt 1):93-100. Unique Identifier : AIDSLINE MED/96145138; Hohdatsu T; Hirabayashi H; Motokawa K; Koyama H; Department of Veterinary Infectious Diseases, School of; Veterinary Medicine and Animal Sciences, Kitasato University,; Aomori, Japan.; Feline immunodeficiency virus (FIV) isolates have been classified into subtypes A, B, C and D based on the env gene V3-V5 sequence. The cell tropism of seven new Japanese isolates and a Petaluma (prototype) isolate of FIV, which classified into subtypes A, B and D, for feline lymphoblastoid and feline fibroblastoid ce
Cyclosporin A does not reverse clinical resistance to paclitaxel in patients with relapsed non-Hodgkin's lymphoma.: J Clin Oncol. 1996 Jan;14(1):233-9. Unique Identifier : AIDSLINE MED/96140305; Sarris AH; Younes A; McLaughlin P; Moore D; Hagemeister F; Swan F; Rodriguez MA; Romaguera J; North L; Mansfield P; Callendar D; Mesina O; Cabanillas F; Department of Hematology, University of Texas M.D. Anderson; Cancer Center, Houston 77030, USA.; PURPOSE: Cyclosporin A has been shown to reverse paclitaxel resistance in vitro by inhibiting P-gp function. Therefore, we determined whether addition of cyclosporine to paclitaxel reversed clinical paclitaxel resistance in patients with non-Hodgkin s lymphoma (NHL). PATIENTS AND M
Necrotizing ulcerative gingivitis, periodontitis, and stomatitis: clinical staging and predisposing factors.: J Periodontol. 1995 Nov;66(11):990-8. Unique Identifier : AIDSLINE MED/96162545; Horning GM; Cohen ME; Naval Dental School, Bethesda, MD, USA.; Necrotizing ulcerative gingivitis (NUG), necrotizing ulcerative periodontitis (NUP), and necrotizing stomatitis (NS), collectively termed necrotizing gingivostomatitis (NG), represent a dramatic, but rare oral infection associated with diminished systemic resistance, including HIV infection. Over a 5-year period, 68 c
Cationized hyperimmune immunoglobulins: pharmacokinetics, toxicity evaluation and treatment of human immunodeficiency virus-infected human-peripheral blood lymphocytes-severe combined immune deficiency mice.: J Pharmacol Exp Ther. 1996 Jan;276(1):246-52. Unique Identifier : AIDSLINE MED/96135073; Pardridge WM; Kang YS; Diagne A; Zack JA; Department of Medicine, University of California at Los Angeles; School of Medicine, USA.; The in vivo pharmacokinetics and efficacy of cationized human immunoglobulins in the human-peripheral blood lymphocytes-severe combined immune deficiency mouse model were evaluated in the present studies using the severe combined immunodeficient mouse transplanted with human lymphocytes and infected with human immunod
Biological and biochemical anti-human immunodeficiency virus activity of UC 38, a new non-nucleoside reverse transcriptase inhibitor.: J Pharmacol Exp Ther. 1996 Jan;276(1):298-305. Unique Identifier : AIDSLINE MED/96135081; McMahon JB; Buckheit RW Jr; Gulakowski RJ; Currens MJ; Vistica DT; Shoemaker RH; Stinson SF; Russell JD; Bader JP; Narayanan VL; Schultz RJ; Brouwer WG; Felauer EE; Boyd MR; Laboratory of Drug Discovery Research and Development, National; Cancer Institute, Frederick, Maryland, USA.; UC 38, a simple analog of oxathiin carboxanilide, UC 84, lacking the oxathiin ring, was found to be a potent inhibitor of human immunodeficiency virus (HIV)-1-induced cell killing and HIV replication in a variety of human cell lines, as well as in human peripheral blood lymphocytes and macrophages. UC 38 was active ag
A novel, picomolar inhibitor of human immunodeficiency virus type 1 protease.: J Med Chem. 1996 Jan 19;39(2):392-7. Unique Identifier : AIDSLINE MED/96145172; Sham HL; Zhao C; Stewart KD; Betebenner DA; Lin S; Park CH; Kong XP; Rosenbrook W Jr; Herrin T; Madigan D; Vasavanonda S; Lyons N; Molla A; Saldivar A; Marsh KC; McDonald E; Wideburg NE; Denissen JF; Robins T; Kempf DJ; Plattner JJ; Norbeck DW; Pharmaceutical Products Division, Abbott Laboratories, Abbott; Park, Illinois 60064-3500.; The design, synthesis, and molecular modeling studies of a novel series of azacyclic ureas, which are inhibitors of human immunodeficiency virus type 1 (HIV-1) protease that incorporate different ligands for the S1 , S2, and S2 substrate-binding sites of HIV-1 protease are described. The synthesis of this series is h
Metal-chelating inhibitors of a zinc finger protein HIV-EP1. Remarkable potentiation of inhibitory activity by introduction of SH groups.: J Med Chem. 1996 Jan 19;39(2):503-7. Unique Identifier : AIDSLINE MED/96145184; Fujita M; Otsuka M; Sugiura Y; Institute for Chemical Research, Kyoto University, Japan.; HIV-EP1 is a C2H2 type zinc finger protein which binds to DNA kappa B site present in the long terminal repeat of HIV provirus. Previously we have reported zinc chelators having histidine--pyridine--histidine skeleton and were successful in inhibiting the DNA binding of HIV-EP1 by removing zinc from the zinc finger do
Correlation of anti-HIV potency with lipophilicity in a series of cosalane analogs having normal alkenyl and phosphodiester chains as cholestane replacements.: J Med Chem. 1996 Jan 19;39(2):508-14. Unique Identifier : AIDSLINE MED/96145185; Keyes RF; Golebiewski WM; Cushman M; Department of Medicinal Chemistry and Pharmacognosy, School of; Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA.; In order to define the role of the cholestane moiety in the anti-HIV agent cosalane, a series of cosalane analogs was synthesized in which the cholestane ring system was replaced by normal alkenyl and phosphodiester substituents having varied chain lengths and lipophilicities. The compounds containing simple alkenyl s
2-Sulfonyl-4-chloroanilino moiety: a potent pharmacophore for the anti-human immunodeficiency virus type 1 activity of pyrrolyl aryl sulfones.: J Med Chem. 1996 Jan 19;39(2):522-30. Unique Identifier : AIDSLINE MED/96145187; Artico M; Silvestri R; Massa S; Loi AG; Corrias S; Piras G; La Colla P; Dipartimento di Studi Farmaceutici, Universita di Roma, Italy.; The synthesis and the evaluation of cytotoxicity and anti-HIV-1 activity of new aryl pyrrolyl (8) and aryl indolyl (9) sulfones are reported. Preparation of above sulfones was achieved by reacting arylsulfonyl chlorides with substituted pyrroles and indoles or by condensing sulfonamides with 2,5-dimethoxytetrahydrofur
Synthesis and antiviral activity of 2'-deoxy-4'-thio purine nucleosides.: J Med Chem. 1996 Jan 19;39(2):538-42. Unique Identifier : AIDSLINE MED/96145189; Van Draanen NA; Freeman GA; Short SA; Harvey R; Jansen R; Szczech G; Koszalka GW; Division of Experimental Therapy, Burroughs Wellcome Company,; Research Triangle Park, North Carolina 27709, USA.; A series of 2 -deoxy-4 -thioribo purine nucleosides was prepared by trans-N-deoxyribosylase-catalyzed reaction of 2 -deoxy-4 -thiouridine with a variety of purine bases. This synthetic procedure is an improvement over methods previously used to prepare purine 4 -thio nucleosides. The compounds were tested against hepa
An ethical approach to HIV carriage and AIDS [letter]: J Med Ethics. 1995 Oct;21(5):311-2. Unique Identifier : AIDSLINE MED/96122513; Nores JM
Voiding dysfunction in human immunodeficiency virus infections.: J Urol. 1996 Feb;155(2):523-6. Unique Identifier : AIDSLINE MED/96134288; Kane CJ; Bolton DM; Connolly JA; Tanagho EA; Department of Urology, University of California School of; Medicine, San Francisco 94143-0738, USA.; PURPOSE: We prospectively evaluated the current spectrum of urodynamic pathology in patients infected with human immunodeficiency virus (HIV) who presented with voiding dysfunction. MATERIALS AND METHODS: We obtained a directed genitourinary and neurological history, and performed a physical examination and urodynamic
School health services.: J Sch Health. 1995 Oct;65(8):319-26. Unique Identifier : AIDSLINE MED/96130430; Small ML; Majer LS; Allensworth DD; Farquhar BK; Kann L; Pateman BC; Surveillance Research Section, Centers for Disease Control and; Prevention, Atlanta, GA 30341-3724, USA.
Alcohol-related risk factors associated with HIV infection among patients entering alcoholism treatment: implications for prevention.: J Stud Alcohol. 1995 Nov;56(6):642-53. Unique Identifier : AIDSLINE MED/96130453; Boscarino JA; Avins AL; Woods WJ; Lindan CP; Hudes ES; Clark W; Center for AIDS Prevention Studies, University of California, San; Francisco 94105, USA.; OBJECTIVE: Reports suggest that alcoholics may be at risk for HIV infection. In this article we examine several alcohol-related risk factors for HIV infection among patients entering alcoholism treatment in an AIDS epicenter. Our objective was to identify key factors for HIV prevention and screening among populations
Playing doctors: refiguring the doctor-patient relationship in Herve Guibert's AIDS novels.: Lit Med. 1995 Fall;14(2):237-49. Unique Identifier : AIDSLINE MED/96122859; Caron D
[Granulomatous pneumonitis: a clinical manifestation and atypical pathology of pneumocystosis in AIDS (letter)]: Med Clin (Barc). 1995 Dec 8;105(20):797. Unique Identifier : AIDSLINE MED/96150977; Macias J; Navarro G; Pineda JA; Lissen E
Recent development in the design of antiviral agents.: Med Res Rev. 1995 Nov;15(6):497-531. Unique Identifier : AIDSLINE MED/96130678; Saunders J; Cameron JM; Department of Medicinal Chemistry II, Glaxo Research and; Development Limited, Stevenage, Herts, UK.
TNF and AIDS: two sides of the same coin?: Med Res Rev. 1995 Nov;15(6):533-46. Unique Identifier : AIDSLINE MED/96130679; Pallares-Trujillo J; Lopez-Soriano FJ; Argiles JM; Departament de Bioquimica i Fisiologia, Facultat de Biologia,; Universitat de Barcelona, Spain.
[Relationship between chronic liver diseases and hepatitis C in Burundi adults]: Med Trop (Mars). 1995;55(3):235-7. Unique Identifier : AIDSLINE MED/96141169; Aubry P; Larouze B; Muhirwa G; Henzel D; Ndabaneze E; Nsabimana JM; Departement de Medecine Interne, Centre Hospitalier; Universitaire Kamenge, Bujumbura, Burundi.; A case/control study was conducted in Bujumbura, Burundi , from 1991 to 1992 to assess the relationship between chronic liver disease and hepatitis C virus (HCV). Patients presenting chronic liver disease (n = 80) were selected based on clinical, laboratory, ultrasonographic, and/o
[Kaposi's sarcoma in dermatology consultations at Lome, Togo]: Med Trop (Mars). 1995;55(3):246-8. Unique Identifier : AIDSLINE MED/96141172; Pitche P; Kombate K; Napo-Koura G; Mijiyawa M; Tchangai-Walla K; Service de Dermatologie, Centre Hospitalier Universitaire Tokoin,; Lome, Togo.; The purpose of this retrospective study conducted in a dermatologic out patient clinic in Lome was to assess the epidemiologic, clinical, and prognostic profile of Kaposi s sarcoma in Togo during the 15 years period between 1980 and 1994. Only patients who had undergone serologic tes
[Bilharziasis and human immunodeficiency virus infection in Congo]: Med Trop (Mars). 1995;55(3):249-51. Unique Identifier : AIDSLINE MED/96141173; N'Zoukoudi-N'Doundou MY; Dirat I; Akouala JJ; Penchenier L; Makuwa M; Rey JL; Laboratoire d'Epidemiologie des Grandes Endemies Tropicales,; Brazzaville, Congo.; To assess the relationship between schistosomiasis and human immunodeficiency virus (HIV) infection, a cross-sectional study of HIV seroprevalence was carried out in 1992 in a village in the Bouenza region of the Congo where there is a high incidence of urinary schistosomiasis. No correlation was found between eggs in
[Autopsy findings in 70 AIDS patients who died in a department of pneumology in Ivory Coast: impact of tuberculosis]: Med Trop (Mars). 1995;55(3):252-4. Unique Identifier : AIDSLINE MED/96141174; Domoua K; N'Dhatz M; Coulibaly G; Traore F; Konan JB; Lucas S; Beaumel A; De Cock KM; Dago-Akribi A; Yapi A; Service de Pneumo-phtisiologie, Centre Hospitalier Universitaire; de Treichville, Projet RETRO-CI, Cote d'Ivoire.; Based on autopsy findings in 70 patients infected by human immunodeficiency virus (HIV) who died in the Pulmonology Department of the Treichville University Hospital Center in Abidjan, Ivory Coast . the authors assess the incidence of tuberculosis as the cause of death and anal
[Noma or cancrum oris: etiopathogenic and nosologic aspects]: Med Trop (Mars). 1995;55(3):263-73. Unique Identifier : AIDSLINE MED/96141177; Costini B; Larroque G; Duboscq JC; Montandon D; Service de Chirurgie Maxillo-faciale et Plastique de la Face,; Centre Hospitalier Universitaire Nord, Marseille, France.; Noma is a gangrenous disease that usually begins in the mouth and is characterized by rapid necrotizing destruction of soft tissue and underlying bone. The disease, which is associated with a strong putrid odor suggestive of mixed bacterial infection, develops only in predisposed persons, especially children whose nat
A new wave of treatments for HIV infection is on the horizon.: Mo Med. 1995 Oct;92(10):638-9. Unique Identifier : AIDSLINE MED/96072283; McKinsey D; Kansas City AIDS Research Consortium, USA.
Mycetoma due to Exophiala jeanselmei and Mycobacterium chelonae in a 73-year-old man with idiopathic CD4+ T lymphocytopenia.: Mycoses. 1995 Jul-Aug;38(7-8):271-6. Unique Identifier : AIDSLINE MED/96129847; Neumeister B; Zollner TM; Krieger D; Sterry W; Marre R; Abteilung Medizinische Mikrobiologie und Hygiene, Instituts fur; Medizinische Mikrobiologie und Immunologie, Ulm, Germany.; Exophiala jeanselmei and Mycobacterium chelonae were isolated from cutaneous nodules in a 73-year-old man with mycetoma of the right lower leg. Further evaluation revealed CD4+ lymphocytopenia without evidence of HIV infection. Antibodies to HIV 1/2, p24 antigen and HIV 1/2 (PCR) and reverse transcriptase activity wer
Herpesvirus-like DNA sequence in angiosarcoma in a patient without HIV infection [letter]: N Engl J Med. 1996 Feb 22;334(8):540-1. Unique Identifier : AIDSLINE MED/96157034; Gyulai R; Kemeny L; Kiss M; Adam E; Nagy F; Dobozy A
Tokyo professor accused of perjury over evidence of HIV infection [news]: Nature. 1996 Feb 1;379(6564):388. Unique Identifier : AIDSLINE MED/96158862
[Frequency and mode of use of testing for HIV infection in women hospitalized for childbirth]: Minerva Ginecol. 1995 Oct;47(10):439-45. Unique Identifier : AIDSLINE MED/96158251; Puro V; Romano S; De Santis MT; Aloisi MS; D'Ubaldo C; Girardi E; Ippolito G; Centro di Riferimento AIDS, Ospedale L. Spallanzani, Roma.; OBJECTIVE: To assess the use of HIV testing because of pregnancy. DESIGN: Cross-sectional study. PATIENTS: Parturients admitted to the obstetric divisions of a public hospital located in Rome (February-April 1994). INTERVENTION: Standardized interview during post test counseling. OUT-COMES: Frequency and characteristi
Pregnancy rates among women infected with human immunodeficiency virus. Adult/Adolescent HIV Spectrum of Disease Project Group.: Obstet Gynecol. 1996 Feb;87(2):195-8. Unique Identifier : AIDSLINE MED/96148892; Chu SY; Hanson DL; Jones JL; Division of HIV/AIDS Prevention, Centers for Disease Control and; Prevention, Atlanta, Georgia, USA.; OBJECTIVE: To examine pregnancy rates among women infected with human immunodeficiency virus (HIV). METHODS: We used data from an ongoing survey of medical records of 3915 women who were 15-44 years of age, infected with HIV, and who received care between January 1990 and August 1994 in more than 90 clinics, hospitals
Myelopathy as a presenting sign of acquired immunodeficiency syndrome.: Pediatr Infect Dis J. 1995 Sep;14(9):808-9. Unique Identifier : AIDSLINE MED/96079361; Fiser RT; Hickerson SL; Sharp GB; Schutze GE; University of Arkansas for Medical Science, Little Rock, USA.
How long may perinatally acquired human immunodeficiency virus infection last asymptomatically? [letter]: Pediatr Infect Dis J. 1995 Sep;14(9):821-2. Unique Identifier : AIDSLINE MED/96079370; Manfredi R; Ragazzini I; Zucchini A; Di Fiore MT; Manfredi G
Maddening inaction [news]: Nurs Times. 1995 Dec 13-19;91(50):14-5. Unique Identifier : AIDSLINE MED/96153294; Day M
[Informing a child about his illness in HIV infection: words and meaning]: Psychiatr Enfant. 1995;38(1):109-39. Unique Identifier : AIDSLINE MED/96137090; Funck-Brentano I; Departement de Pediatrie, Hopital Necker-Enfants malades.; The account of the medical and psychological treatment of Pascal over a period of three years shows the complexity and the stakes of the problem that families and the medical core are faced with when confronted to a child infected by the HIV: to talk of his infection or his illness. How do you approach the problem wit
Comments on Alcohol use and risky sex among college students.: Psychol Rep. 1995 Oct;77(2):421-2. Unique Identifier : AIDSLINE MED/96130884; Ridley DR; Greenlee SP; Department of Psychology, Christopher Newport University, Newport; News, VA 23606-2988, USA.
Willingness to work with and sympathy for HIV-positive coworkers: an experimental examination of mode of transmission concern, and knowledge.: Psychol Rep. 1995 Oct;77(2):571-6. Unique Identifier : AIDSLINE MED/96130900; Zagumny MJ; Deckbar R; Tennessee Technological University, Department of School Services; Personnel and Psychology, Cookeville 38505, USA.; This study investigated concern about HIV infection, knowledge about HIV/AIDS, and mode of transmission on willingness to work with and sympathy expressed towards a coworker with AIDS. 120 undergraduate students were randomly assigned to one of 12 groups in a 3 x 4 between-subjects design. Subjects viewed one of three
Gender differences of reported safer sex behaviors within a random sample of college students.: Psychol Rep. 1995 Dec;77(3 Pt 1):963-8. Unique Identifier : AIDSLINE MED/96130949; Hawkins WE; Gray C; Hawkins WE; Catholic University of America, National Catholic School of; Social Service, Washington, DC 20064, USA.; This study investigated the frequency of safer sex behaviors with a random sample of sexually active college students (N = 315) at a university in the Northwest. The most frequent safer sex behaviors were discussion of contraceptives (58.6%), being more selective (46.5%), and reducing the number of sexual partners (43
How many HIV infections are there in Israel? Reconstructing HIV incidence from AIDS case reporting.: Public Health Rev. 1995;23(3):215-35. Unique Identifier : AIDSLINE MED/96137686; Kaplan EH; Slater PE; Soskolne V; Hebrew University-Hadassah Braun School of Public Health and; Community Medicine, Jerusalem, Israel.; BACKGROUND: The reporting of AIDS cases to Israel s Ministry of Health is believed to be accurate, but the completeness of HIV surveillance is unknown. We implement a model that reconstructs HIV incidence in Israel from AIDS case reports excluding Ethiopian immigrants. METHODS: We apply the well-known method of backca
[Parasitic and viral marker detection in pregnant adolescents and their newborn infants at risk]: Rev Chil Obstet Ginecol. 1995;60(2):85-9. Unique Identifier : AIDSLINE MED/96093537; Contreras MC; Escaff V; Salinas P; Saavedra T; Suarez M; Departamento de Parasitologia, Facultad de Medicina, Universidad; de Chile.; We have investigated the prevalence of antibodies against Toxoplasma gondii, Trypanosoma cruzzi, Hepatitis B virus, cytomegalovirus , rubella virus, and human immunodeficiency virus in 139 adolescent pregnant women and in their high risk newborn children. The methods employed were t
[Muscle pain and swelling in a HIV-positive patient]: Rev Clin Esp. 1995 Nov;195(11):811-2. Unique Identifier : AIDSLINE MED/96158300; de la Fuente Aguado J; Moreno Sanjuan JA; Martinez-Vazquez C; Estevez Diz A; Fernandez Villar A; Sopena Perez-Arguelles B; Servicio de Medicina Interna, Unidad de Enfermedades Infecciosas,; Complejo Hospitalario Xeral-Cies, Vigo.
[Ischemic cerebrovascular incident associated with crack consumption (letter)]: Rev Clin Esp. 1995 Nov;195(11):814. Unique Identifier : AIDSLINE MED/96158302; Santamaria A; Ormaechea E; Guardiola J; Domingo P
Probability and characteristics of human immunodeficiency virus infection in male Greek military personnel with tuberculosis.: Respiration. 1995;62(5):280-5. Unique Identifier : AIDSLINE MED/96079419; Bouros D; Panagou P; Tzanakis N; Siafakas N; Department of Thoracic Medicine, Medical School, University of; Crete, Heraklion, Greece.; The probability of an AIDS patient being infected with tuberculosis (TB) has been studied in different populations and found to be increased by as much as 500 times, but the reverse, i.e. the probability of a patient with TB being infected with HIV, has not been studied. The aim of this study was to investigate the hy
[Microsporidiosis in patients with chronic diarrhea and AIDS, in HIV asymptomatic patients and in patients with acute diarrhea]: Rev Med Chil. 1995 Jul;123(7):849-56. Unique Identifier : AIDSLINE MED/96093577; Weitz JC; Botehlo R; Bryan R; Departamento de Medicina, Facultad de Medicina (Campus Oriente),; Universidad de Chile, Santiago de Chile.; Microsporidia are intracellular protozoa that mainly affect AIDS patients and chronic diarrhea, caused by the strains Enterocytozoon bieneusi and Septata intestinalis, is the most common clinical manifestation. The diagnosis is made in intestinal biopsies, however the recently developed trichromic stain with chromotro
[HIV-associated nephropathy]: Rev Hosp Clin Fac Med Sao Paulo. 1995 Jul-Aug;50(4):189-90. Unique Identifier : AIDSLINE MED/96093558; de Menezes MR; de Oliveira IR; Saito O de C; Instituto de Radiologia, Hospital das Clinicas, Faculdade de; Medicina, USP.; AIDS can affect many parenchymal organs but the renal involvement is of vital value for patient s prognosis. Sonography can easily analyse most of all renal insult even in those patients without symptoms.
[Facial and cervical manifestations of AIDS]: Rev Hosp Clin Fac Med Sao Paulo. 1995 Jul-Aug;50(4):222-6. Unique Identifier : AIDSLINE MED/96093564; Gebrim EM; Gomes RL; Bambirra S; Rocha M de S; Setor de Tomografia Computadorizada, Hospital das Clinicas,; Faculdade de Medicina da USP.; The manifestations of the acquired immunodeficiency syndrome (AIDS) are common in the head and neck and include opportunistic infections, malignancies and diffuse reactive adenopathy. This article reviews the usual and unusual manifestation of AIDS affections of the parotid gland, sinonasal and oral cavity, nasopharyn
HLA-B27-restricted cytotoxic T lymphocyte responses to arthritogenic enterobacteria or self-antigens are dominated by closely related TCRBV gene segments. A study in patients with reactive arthritis.: Scand J Immunol. 1996 Jan;43(1):101-8. Unique Identifier : AIDSLINE +; Duchmann R; May E; Ackermann B; Goergen B; Meyer zum Buschenfelde KH; Marker-Hermann E; First Department of Medicine, Johannes Gutenberg University of; Mainz, Germany.; Identification of the T-cell receptors (TCR) used by synovial cytotoxic T lymphocytes (CTL) of patients with reactive arthritis (ReA) may be crucial to better understanding the pathogenetic mechanism underlying the HLA-B27 association of spondylarthropathies. The authors, therefore, sequenced 25 TCRB chains from HLA-B
Chagasic patients lack CD28 expression on many of their circulating T lymphocytes.: Scand J Immunol. 1996 Jan;43(1):88-93. Unique Identifier : AIDSLINE MED/96151206; Dutra WO; Martins-Filho OA; Cancado JR; Pinto-Dias JC; Brener Z; Gazzinelli G; Carvalho JF; Colley DG; Centro de Pesquisas Rene Rachou, FIOCRUZ, Belo Horizonte,; Brazil.; A balanced host-parasite interaction during Trypanosoma cruzi infection allows for the establishment of a chronic infection that can last for many years. T cells are a major element responsible for parasite specific and non-specific immunity during the complex immune response of the host. However, the subpopulations o
IFN-gamma restores HIV- and non-HIV-specific cell mediated immune response in vitro and its activity is neutralized by antibodies from patients with AIDS.: Scand J Immunol. 1996 Jan;43(1):94-100. Unique Identifier : AIDSLINE MED/96151207; De Francesco MA; Caruso A; Dima F; Cantalamessa A; Canaris AD; Folghera S; Fiorentini S; Flamminio G; Licenziati S; Peroni L; Gao J; Garotta G; Turano A; Insitute of Microbiology, University of Brescia, Italy.; The addition of IFN-gamma to cultures of peripheral blood mononuclear cells (PBMCs) obtained from asymptomatic HIV-infected patients increased cell proliferation in response to HIV envelope synthetic peptides (Env), influenza A virus (VIRUS), and allogeneic lymphocytes (ALLO) but not to phytohaemagglutinin (PHA) stimu
AIDS task force fizzles out [news]: Science. 1996 Jan 26;271(5248):438-9. Unique Identifier : AIDSLINE MED/96152354; Cohen J
Can some infants beat HIV? [news]: Science. 1996 Jan 26;271(5248):441. Unique Identifier : AIDSLINE MED/96152356; Thompson C
Reduction of HIV concentration during acute infection: independence from a specific immune response.: Science. 1996 Jan 26;271(5248):497-9. Unique Identifier : AIDSLINE MED/96152367; Phillips AN; Department of Primary Care and Population Sciences, Royal Free; Hospital School of Medicine, London, UK.; After infection with the human immunodeficiency virus (HIV), the concentration of the virus in the person s plasma increases. The subsequent decrease in concentration a few weeks later was though to result from an HIV-specific immune response. This purported causal relation is investigated with a model of the dynamics
Transfusion-dependent thalassemia: viral complications (epidemiology and follow-up).: Semin Hematol. 1995 Oct;32(4):280-7. Unique Identifier : AIDSLINE MED/96124305; de Montalembert M; Girot R; Mattlinger B; Lefrere JJ; Centre de Transfusion, Hopital Necker, Paris, France.
Social interventions in the care of human immunodeficiency virus (HIV)-infected pregnant women.: Semin Perinatol. 1995 Aug;19(4):323-9. Unique Identifier : AIDSLINE MED/96076548; Levine C; Allen MH; Orphan Project: Families and Children in the HIV Epidemic, New; York, NY 10013, USA.; The incidence of infection with the human immunodeficiency virus (HIV) is increasing among women of childbearing age. Women now account for 18% of the total number of cases of the acquired immunodeficiency syndrome (AIDS), compared with 9% a decade ago. The medical care of pregnant HIV-infected women must take into ac
Fear of AIDS and homophobia: implications for direct practice and advocacy.: Soc Work. 1996 Jan;41(1):51-8. Unique Identifier : AIDSLINE MED/96151936; O'Hare T; Williams CL; Ezoviski A; Graduate School of Social Work, Boston College, Chestnut Hill, MA; 02167-3807, USA.; Studies of health care trainees and professionals have demonstrated that their level of empathy and caring is negatively affected by the knowledge that the person being treated is homosexual, in part because of stigma associated with HIV infection and AIDS. The survey discussed in this article examined the relationshi
Understanding the social needs of streetwalking prostitutes.: Soc Work. 1996 Jan;41(1):97-105. Unique Identifier : AIDSLINE MED/96151940; Weiner A; Wurzweiler School of Social Work, Yeshiva University, New York,; NY 10033, USA.; The social dynamics of prostitution render prostitutes unable at times to meet basic human needs, vulnerable to violence, and at risk for sexually transmitted disease. Since April 1989 a mobile van from a private foundation has been contacting prostitutes throughout the five boroughs of New York City to provide HIV te
Primary xanthoma of thoracic spine presenting with myelopathy.: Spine. 1995 Sep 1;20(17):1933-7. Unique Identifier : AIDSLINE MED/96060156; Robertson DP; Langford LA; McCutcheon IE; Department of Neurosurgery, University of Texas M. D. Anderson; Cancer Center, Houston, USA.; STUDY DESIGN. This retrospective case study reports on a patient with an isolated primary xanthoma arising in the second thoracic vertebra with paravertebral and spinal canal extension. OBJECTIVE. The possibility of this lesion s occurrence in the spine is presented with radiologic and pathologic findings appropriate
Occupational stress among AIDS social service providers.: Soc Work Health Care. 1995;21(3):115-31. Unique Identifier : AIDSLINE MED/96131848; Cushman LF; Evans P; Namerow PB; Center for Population and Family Health, Columbia University; School of Public Health, USA.; This survey reveals high levels of job-related stress among social workers, counselors and health educators working with HIV/AIDS patients in five large, urban medical centers. Stress is associated not only with the severity of AIDS as a disease, but also with several organizational characteristics of respondents job
Tuberculosis and AIDS: the impact on the hospital social worker.: Soc Work Health Care. 1995;21(3):29-41. Unique Identifier : AIDSLINE MED/96131844; Wade K; Stein E; Beckerman N; The second decade of the AIDS epidemic is marked by increasing numbers of people being diagnosed with HIV infection as well as mycobacterium infection (pulmonary tuberculosis). The convergence of these two epidemics presents new challenges for social workers. Serious threat of HIV infection from occupational exposure
Psychosocial outcomes of HIV illness in male and female African American clients.: Soc Work Health Care. 1995;21(3):43-60. Unique Identifier : AIDSLINE MED/96131845; Linn JG; Poku KA; Cain VA; Holzapfel KM; Crawford DF; Tennessee State University, Murfreesboro, USA.; With the rapid growth of HIV infection among African Americans, the issue of how medical problems relate to psychological functioning in the black community population has acquired new meaning and urgency for health care policy. To develop effective strategies to meet the mental health needs of infected African Americ
Occupational exposure of health care workers (HCWs) to human immunodeficiency virus (HIV): stress reactions and counseling interventions.: Soc Work Health Care. 1995;21(3):61-80. Unique Identifier : AIDSLINE MED/96131846; Armstrong K; Gorden R; Santorella G; University of California, San Francisco, USA.; As more people become infected with HIV, Health Care Workers (HCWs) have a greater likelihood of being exposed at work. HIV exposure threatens the life of the HCW and can elicit a stress reaction. Although HCWs have reactions similar to those of people who have been exposed to other traumatic events, the nature of thi
Racial minorities and other high-risk groups with HIV and AIDS at increased risk for psychological adjustment problems in association with health locus of control orientation.: Soc Work Health Care. 1995;21(3):81-114. Unique Identifier : AIDSLINE MED/96131847; Spalding AD; SUNY College, Department of Health Sciences, 14420, USA.; This study compared minority subjects (n = 45) with non-minority subjects (n = 49) with HIV and AIDS, examining levels of perceived locus of control over health status, and whether different health locus of control (HLOC) orientations (internal, powerful others, or chance) determined psychological adjustment as measur
Social work with dying and bereaved clients: helping the workers.: Soc Work Health Care. 1995;21(4):1-16. Unique Identifier : AIDSLINE MED/96134620; Davidson KW; Foster Z; Hunter College School of Social Work, New York, NY 10021, USA.; This paper considers the stresses and satisfactions experienced by health care social workers as they help clients with grief and loss at a time of great fiscal restraint. Their clients face life-threatening illnesses such as AIDS and many forms of cancer. There are untimely losses in families and communities whose re
Five-year follow-up of human anti-mouse antibody in multitransfused HIV negative haemophilics treated with a monoclonal purified plasma derived factor VIII concentrate [letter]: Thromb Haemost. 1995 Oct;74(4):1203. Unique Identifier : AIDSLINE MED/96124420; Smid WM; van der Meer J
High prevalence of Enterocytozoon bieneusi infections among HIV-positive individuals with persistent diarrhoea in Harare, Zimbabwe.: Trans R Soc Trop Med Hyg. 1995 Sep-Oct;89(5):478-80. Unique Identifier : AIDSLINE MED/96142781; van Gool T; Luderhoff E; Nathoo KJ; Kiire CF; Dankert J; Mason PR; Department of Medical Microbiology, University of Amsterdam, The; Netherlands.; Infection with the microsporidian parasite Enterocytozoon bieneusi may be a major cause of prolonged diarrhoea in individuals also infected with human immunodeficiency virus (HIV). The parasite has been reported from Europe, Australia and the Americas, with a prevalence of 7-29%
Prevalence of hepatitis C virus and other blood-borne viruses in Pygmies and neighbouring Bantus in southern Cameroon.: Trans R Soc Trop Med Hyg. 1995 Sep-Oct;89(5):484-6. Unique Identifier : AIDSLINE MED/96142783; Kowo MP; Goubau P; Ndam EC; Njoya O; Sasaki S; Seghers V; Kesteloot H; Department of Gastroenterology and Nutrition, University of; Yaounde, Cameroon.; The prevalences of antibodies to hepatitis C virus (anti-HCV), human immunodeficiency virus (anti-HIV), human T lymphotrophic virus (anti-HTLV) and of hepatitis B surface antigen (HbsAg) were determined in 168 subjects aged 12 years and over (108 Pygmies, 60 Bantus) living in south C
Hodgkin's disease after transplantation.: Transplantation. 1996 Jan 15;61(1):71-6. Unique Identifier : AIDSLINE MED/96144871; Garnier JL; Lebranchu Y; Dantal J; Bedrossian J; Cahen R; Assouline D; Jaccard A; Fetissoff F; Moreau A; Martin X; Delsol G; Berger F; Touraine JL; Inserm U80, Service d'Urologie, Departement d' Hematologie,; Hopital Edouard Herriot, Lyon, France.; Hodgkin s disease (HD) has seldom been reported after transplantation. Epstein-Barr virus (EBV) is present in about 50% of Reed-Sternberg cells in HD developing in immunocompetent individuals, but is more frequently found in HD of acquired immune deficiency syndrome patients. We report 7 cases of HD that occurred in t
The role of endogenous glucocorticoids on host T cell populations in the peripheral lymphoid organs of mice with graft-versus-host disease.: Transplantation. 1996 Jan 15;61(1):76-83. Unique Identifier : AIDSLINE MED/96144872; You-Ten KE; Lapp WS; Department of Physiology, McGill University, Montreal, Quebec,; Canada.; Previously, we demonstrated that immature CD4+8+ and mature CD4+ thymocyte populations were selectively eliminated during murine graft-versus-host disease (GVHD) as a consequence of elevated levels of endogenous glucocorticoids. In this report, we investigated whether the marked reduction of CD4+8+ and CD4+ thymocyte
The changing pattern of mortality in an African medical ward.: Trop Geogr Med. 1995;47(4):171-4. Unique Identifier : AIDSLINE MED/96085991; Harries AD; Mvula B; Department of Medicine, Queen Elizabeth Central Hospital,; Blantyre, Malawi.; The pattern of adult medical deaths in Queen Elizabeth Central Hospital, Blantyre, Malawi was documented over a 12 month period between April 1992 and March 1993. Results were compared with mortality data collected from the same wards in the pre-AIDS era in 1973. Tuberculosis and A
N-linked glycans in the CD4-binding domain of human immunodeficiency virus type 1 envelope glycoprotein gp160 are essential for the in vivo priming of T cells recognizing an epitope located in their vicinity.: Virology. 1996 Jan 15;215(2):124-33. Unique Identifier : AIDSLINE MED/96146726; Sjolander S; Bolmstedt A; Akerblom L; Horal P; Olofsson S; Morein B; Sjolander A; Department of Veterinary Microbiology, College of Veterinary; Medicine, Swedish University of Agricultural Sciences, Uppsala,; Sweden.; Deglycosylation of viral glycoproteins has been suggested to influence the number of available T cell determinants and to increase T cell recognition of antigens. In this study, we have investigated whether T cell responses to the HIV-1 envelope glycoprotein gp160 were influenced by deletion of three N-glycans of the
Coexpression of a nonsyncytium inducer HIV-1 glycoprotein inhibits syncytium formation by another HIV-1 Env protein.: Virology. 1996 Jan 15;215(2):197-202. Unique Identifier : AIDSLINE MED/96146734; Li YY; O'Donnell MA; Perez LG; Molecular Biology and Biotechnology Program, Salem-Teikyo; University-Tampa Bay Research Institute, St. Petersburg, Florida; 33716, USA.; The biosynthesis and biological properties of the envelope glycoprotein from a primary isolate of the human immunodeficiency virus type 1, HIV-1 YU2, and the Env product from the laboratory-adapted strain, HIV-1 LAI were compared in the absence of viral replication. We found that the level of expression and proteolyti
Molecular analysis of human T-cell lymphotropic virus type II from Wayuu Indians of Colombia demonstrates two subtypes of HTLV-IIb.: Virus Genes. 1995;10(2):153-62. Unique Identifier : AIDSLINE GENBANK/U12795; Switzer WM; Owen SM; Pieniazek DA; Nerurkar VR; Duenas-Barajas E; Heneine W; Lal RB; Retrovirus Diseases Branch, Centers for Disease Control and; Prevention, Atlanta, Georgia 30333, USA.; Studies of the genetic heterogeneity of human T-cell lympho