Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells.

Nat Med. 1995 Dec;1(12):1274-8. Unique Identifier : AIDSLINE MED/96083627
Boshoff C; Schulz TF; Kennedy MM; Graham AK; Fisher C; Thomas A; McGee JO; Weiss RA; O'Leary JJ; Virology Laboratory, Royal Marsden Hospital, London, UK.

Abstract: Kaposi's sarcoma (KS), a vascular tumour that contains characteristic spindle cells forming slit-like spaces, may have an infectious aetiology. Recently, sequences of a new human herpesvirus, KSHV/HHV-8, have been identified in both HIV-associated and classical KS. We sought to identify the target cell of this virus in KS tumour tissue. Using PCR in situ hybridization (PCR-ISH) we show that KSHV/HHV-8 is present in the flat endothelial cells lining vascular spaces of KS lesions as well as in typical KS spindle cells. These findings show that KSHV/HHV-8 is present in the cell types thought to represent neoplastic cells in these lesions.
Keywords: Adolescence Adult Aged Aged, 80 and over AIDS-Related Opportunistic Infections/PATHOLOGY/*VIROLOGY Base Sequence Endothelium Female *Herpesviridae Herpesviridae Infections/*VIROLOGY Human In Situ Hybridization Male Middle Age Molecular Sequence Data Nevus, Spindle Cell/*VIROLOGY Polymerase Chain Reaction Sarcoma, Kaposi's/PATHOLOGY/*VIROLOGY Skin Neoplasms/PATHOLOGY/*VIROLOGY Support, Non-U.S. Gov't JOURNAL ARTICLEKWDadolescenceadultagedaged,80andoveraids-relatedopportunisticinfections/pathology/KWDvirologybasesequenceendotheliumfemaleKWDherpesviridaeherpesviridaeinfections/KWDvirologyhumaninsituhybridizationmalemiddleagemolecularsequencedatanevus,spindlecell/KWDvirologypolymerasechainreactionsarcoma,kaposi's/pathology/KWDvirologyskinneoplasms/pathology/KWDvirologysupport,non-uKWDsKWDgov'tjournalarticle
960330
M9630730

Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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