Genetic control of the CD4/CD8 T-cell ratio in humans [see comments] NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Genetic control of the CD4/CD8 T-cell ratio in humans [see comments]

Nat Med. 1995 Dec;1(12):1279-83. Unique Identifier : AIDSLINE MED/96083628
Amadori A; Zamarchi R; De Silvestro G; Forza G; Cavatton G; Danieli GA; Clementi M; Chieco-Bianchi L; Institute of Oncology, Interuniversity Center for Research on; Cancer, University of Padova, Italy.

Abstract: We studied the genetic pattern of inheritance of the ratio between circulating CD4+ and CD8+ T lymphocytes in a population of healthy donors. The distribution of the CD4/CD8 ratio in males and females was significantly different and was significantly affected by age. In 46 randomly selected families, the parental CD4/CD8 ratio significantly influenced the ratio in offspring. Complex segregation analysis of the data rejected the non-genetic hypothesis; among the genetic models tested, a major recessive gene with a polygenic component and random environmental effects was the most parsimonious model. These findings indicate that the ratio of CD4+ and CD8+ T cells is genetically controlled in humans.
Keywords: Adult Age Factors *CD4-CD8 Ratio CD4-Positive T-Lymphocytes/*IMMUNOLOGY/ULTRASTRUCTURE CD8-Positive T-Lymphocytes/*IMMUNOLOGY/ULTRASTRUCTURE Female Genes, Recessive Genetics, Population Human Italy Male Models, Genetic *Phenotype Sex Factors Support, Non-U.S. Gov't JOURNAL ARTICLEKWDadultagefactorsKWDcd4-cd8ratiocd4-positivet-lymphocytes/KWDimmunology/ultrastructurecd8-positivet-lymphocytes/KWDimmunology/ultrastructurefemalegenes,recessivegenetics,populationhumanitalymalemodels,geneticKWDphenotypesexfactorssupport,non-uKWDsKWDgov'tjournalarticle
Comment in: Nat Med 1995 Dec;1(12):1240-1
960330
M9630729

Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1996. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1996. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .