[DNA polymorphism of the BoLA-DRB3 gene in cattle in connection with resistance and susceptibility to leukemia] NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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[DNA polymorphism of the BoLA-DRB3 gene in cattle in connection with resistance and susceptibility to leukemia]

Genetika. 1995 Sep;31(9):1294-9. Unique Identifier : AIDSLINE MED/96067854
Sulimova GE; Udina IG; Shaikhaev GO; Zakharov IA

Abstract: Polymorphism of exon 2 of the BoLA-DRB3 gene was investigated by the PCR-RFLP method in a sample of healthy and leukemia-afflicted Black Pied cattle. Allele variety was studied and allele frequencies were determined in a total sample and in the two groups. Alleles mediating resistance (BoLA-DRB3.2*11, *23, and *28) and susceptibility to leukemia (DRB3.2*22, *24, *16, and *8) were revealed in Black Pied cattle. The dominant type of inheritance of the disease resistance was confirmed. On the basis of original and published data obtained earlier for Holstein-Friesian cattle, a conclusion was made about the universal character of the spectrum of BoLA-DRB3 alleles providing resistance and susceptibility to leukemia.
Keywords: Alleles Animal Base Sequence Cattle/*GENETICS/IMMUNOLOGY Disease Susceptibility/GENETICS DNA DNA Primers English Abstract Enzootic Bovine Leukosis/*GENETICS/IMMUNOLOGY Exons Gene Amplification Gene Frequency Histocompatibility Antigens/*GENETICS Molecular Sequence Data Polymerase Chain Reaction *Polymorphism (Genetics) Restriction Mapping JOURNAL ARTICLEKWDallelesanimalbasesequencecattle/KWDgenetics/immunologydiseasesusceptibility/geneticsdnadnaprimersenglishabstractenzooticbovineleukosis/KWDgenetics/immunologyexonsgeneamplificationgenefrequencyhistocompatibilityantigens/KWDgeneticsmolecularsequencedatapolymerasechainreactionKWDpolymorphism(genetics)restrictionmappingjournalarticle
960330
M9630710

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