Similar serological response to conventional therapy for syphilis among HIV-positive and HIV-negative women.

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Similar serological response to conventional therapy for syphilis among HIV-positive and HIV-negative women.

Genitourin Med. 1995 Oct;71(5):275-9. Unique Identifier : AIDSLINE MED/96096203
Goeman J; Kivuvu M; Nzila N; Behets F; Edidi B; Gnaore E; Van Dyck E; St. Louis M; Piot P; Laga M; Projet SIDA, Ministry of Health, Kinshasa, Zaire.

Abstract: OBJECTIVES--To compare characteristics of syphilis serological reactivity in HIV positive (+) and HIV negative (-) female sex workers, as well as the serological response to therapy after treatment with intramuscular benzathine penicillin, 2.4 million U weekly, for three consecutive weeks. METHODS--Rapid plasma reagin (RPR) and Treponema pallidum haemagglutination assay (TPHA) results of 72 HIV-positive and 121 HIV-negative women reactive in both tests were assessed. The response to therapy was prospectively monitored with quantitative RPR serology in 47 HIV-positive and 73 HIV-negative patients. Cumulative probabilities of becoming nonreactive by RPR were compared at six months, one and two years after therapy. RESULTS--At enrolment, the geometric mean titres of RPR and TPHA were lower in HIV-positive patients (RPR, 1:2.6) than in HIV-negative patients (RPR, 1:3.8; p < 0.01). The evolution over time of RPR titres was similar among HIV-positive patients as compared to HIV-negative patients. Among patients with an initial RPR titre of < 1:8, 53% of HIV-positive and 44% of HIV-negative patients became RPR negative two years after therapy. Among patients with an RPR titre of 1:8 or greater at enrolment, 83% of HIV-positive and 90% of HIV-negative patients had reached at least a fourfold decline of RPR titres two years after therapy. CONCLUSIONS--Syphilis serology findings (both RPR and TPHA) may be altered in the presence of HIV infection, but the serological response to therapy was similar in HIV-positive and HIV-negative patients.

Keywords: Adult Comparative Study Cross-Sectional Studies Female Hemagglutination Tests Human *HIV Seronegativity HIV Seropositivity/*COMPLICATIONS Penicillin G, Benzathine/THERAPEUTIC USE Penicillins/THERAPEUTIC USE Prospective Studies Reagins/BLOOD Support, Non-U.S. Gov't Syphilis/COMPLICATIONS/*DRUG THERAPY/*IMMUNOLOGY Treponema pallidum/IMMUNOLOGY JOURNAL ARTICLE
960330
M9630706

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