Two-step development of Hashimoto-like thyroiditis in genetically autoimmune prone non-obese diabetic mice: effects of iodine-induced cell necrosis.

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Two-step development of Hashimoto-like thyroiditis in genetically autoimmune prone non-obese diabetic mice: effects of iodine-induced cell necrosis.

J Endocrinol. 1995 Nov;147(2):311-20. Unique Identifier : AIDSLINE MED/96096304
Many MC; Maniratunga S; Varis I; Dardenne M; Drexhage HA; Denef JF; Laboratory of Histology, Catholic University of Louvain, Medical; School, Brussels, Belgium.

Abstract: The administration of a high iodide dose (HID; 10 micrograms/day) to goitrous mice is known to induce thyroid cell necrosis and inflammation, which, in most strains, is transient. In this study, we analyzed the effects of iodide in autoimmune prone non-obese diabetic (NOD) mice. Control NOD mice fed a standard diet (MID; 1 microgram I/day) or HID did not spontaneously develop thyroiditis. In NOD mice previously made goitrous, HID provoked thyroid cell necrosis and diffuse inflammation within 4 days. Inflammatory cells consisted of MHC-class II+ antigen-presenting cells, CD4+ T helper cells and CD8+ T suppressor/cytotoxic cells. After 96 days of treatment with HID, thyroiditis similar to Hashimoto's disease was obtained in 100% of the animals, with destruction of thyroid follicles, large clusters of T and B cells, and antithyroid antibodies in the plasma. When treating goitrous mice with MID, no cell necrosis was observed and no autoimmune thyroiditis was obtained. The early iodide-induced cell necrosis and inflammation may thus be considered as an important factor in the induction and persistence of autoimmune thyroiditis in individuals carrying a genetic susceptibility to autoimmune disease.

Keywords: Animal Antigen-Presenting Cells/IMMUNOLOGY CD4-Positive T-Lymphocytes/IMMUNOLOGY CD8-Positive T-Lymphocytes/IMMUNOLOGY Disease Susceptibility Female Fluorescent Antibody Technique, Indirect Goiter/IMMUNOLOGY Histocompatibility Antigens Class II/IMMUNOLOGY Immunohistochemistry Inflammation Iodides/ADMINISTRATION & DOSAGE/*ADVERSE EFFECTS Mice Mice, Inbred NOD/*IMMUNOLOGY Necrosis Support, Non-U.S. Gov't Thyroid Gland/*DRUG EFFECTS/IMMUNOLOGY/PATHOLOGY Thyroiditis, Autoimmune/*CHEMICALLY INDUCED/GENETICS/PATHOLOGY JOURNAL ARTICLE
960330
M9630681

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