1996

Dermatologic surgery and AIDS. Introduction.: Semin Dermatol. 1995 Sep;14(3):187-90. Unique Identifier : AIDSLINE MED/96053228; Harahap M
The epidemiology of HIV/AIDS.: Semin Dermatol. 1995 Sep;14(3):191-201. Unique Identifier : AIDSLINE MED/96053229; Hughes MJ; Rutherford GW; HIV/AIDS Epidemiology Branch, Office of AIDS, California; Department of Health Services, Sacramento, USA.
Transmission of HIV infection.: Semin Dermatol. 1995 Sep;14(3):202-4. Unique Identifier : AIDSLINE MED/96053230; Cusini M; Institute of Dermatological Science, University of Milan, Italy.
Risk of acquiring AIDS from salivary exchange through cardiopulmonary resuscitation courses and mouth-to-mouth resuscitation.: Semin Dermatol. 1995 Sep;14(3):205-11. Unique Identifier : AIDSLINE MED/96053231; Sun D; Bennett RB; Archibald DW; Department of Oral Pathology, Dental School, University of; Maryland at Baltimore, USA.; In summary, the risk of transmission of HIV and other infectious diseases by saliva during CPR training practice is extremely low because of low infectious virus titers and properties of saliva that inhibit HIV. However, it is necessary to perform decontaminations of mannequins, by application of a suitable disinfecta
HIV infection in healthcare workers: risk for infection and methods of prevention.: Semin Dermatol. 1995 Sep;14(3):212-8. Unique Identifier : AIDSLINE MED/96053232; Beekmann SE; Henderson DK; Hospital Epidemiology Service, National Institutes of Health,; Bethesda, MD 20892.
The potential role of simple dermatologic surgery techniques in transmitting HIV infection.: Semin Dermatol. 1995 Sep;14(3):219-27. Unique Identifier : AIDSLINE MED/96053233; Spencer J; Katz BE; Department of Dermatology and Cutaneous Surgery, University of; Miami, FL, USA.
Management of occupational exposure to HIV.: Semin Dermatol. 1995 Sep;14(3):235-9. Unique Identifier : AIDSLINE MED/96053235; Critchley SE; Castro KG; Hospital Infections Program, HIV Infections Branch, CDC, Atlanta,; GA 30333, USA.
Dermatologic surgery personnel with AIDS.: Semin Dermatol. 1995 Sep;14(3):240-2. Unique Identifier : AIDSLINE MED/96053236; Resnik SS; Resnik BI; Department of Dermatology and Cutaneous Surgery, University of; Miami School of Medicine, FL, USA.
Sterilization and disinfection of instruments and materials in the surgery unit and laboratory areas.: Semin Dermatol. 1995 Sep;14(3):243-6. Unique Identifier : AIDSLINE MED/96053237; Best M; Kennedy ME; Office of Biosafety, Laboratory Centre for Disease Control,; Health Canada, Ottawa, Ontario, Canada.
Patient rights and physician responsibility: four problems in AIDS care.: Semin Dermatol. 1995 Sep;14(3):252-8. Unique Identifier : AIDSLINE MED/96053239; Cooke M; Division of General Internal Medicine, University of California,; San Francisco 94143, USA.
Gene therapy and HIV disease.: AIDS Clin Rev. 1995-96;:1-45. Unique Identifier : AIDSLINE MED/96089196; Poeschla EM; Wong-Staal F; University of California-San Diego, La Jolla, USA.
Bacterial infections in HIV disease.: AIDS Clin Rev. 1995-96;:131-52. Unique Identifier : AIDSLINE MED/96089200; Currier JS; Feinberg J; Los Angeles County and University of Southern California Medical; Center, USA.
Mycobacterium avium complex infection in AIDS.: AIDS Clin Rev. 1995-96;:153-228. Unique Identifier : AIDSLINE MED/96089201; Kemper CA; Deresinski SC; Santa Clara Valley Medical Center, San Jose, California, USA.
Pathophysiology and treatment of the AIDS wasting syndrome.: AIDS Clin Rev. 1995-96;:229-75. Unique Identifier : AIDSLINE MED/96089202; Kotler DP; Grunfeld C; St. Luke's-Roosevelt Hospital Center, New York, New York, USA.
HIV viral load quantification, HIV resistance, and antiretroviral therapy.: AIDS Clin Rev. 1995-96;:277-303. Unique Identifier : AIDSLINE MED/96089203; Katzenstein DA; Holodniy M; Stanford University School of Medicine, California, USA.; We are moving rapidly beyond a black box understanding of the pathogenesis of HIV. The sites of virus replication, the molecular regulation of virus production in the host, and the dynamics between productive virus infection and immunological and clinical events are areas of intense study using powerful new tools. The
New developments in antiretroviral drug therapy for HIV-1 infections.: AIDS Clin Rev. 1995-96;:305-46. Unique Identifier : AIDSLINE MED/96089204; Johnson VA; Center for AIDS Research, University of Alabama, Birmingham; School of Medicine, USA.
Update on epidemiology of AIDS in Asia.: AIDS Clin Rev. 1995-96;:347-86. Unique Identifier : AIDSLINE MED/96089205; Li PC; Yeoh EK; Queen Elizabeth Hospital, Hong Kong.
Multiple opportunistic pathogen prophylaxis for patients with advanced HIV disease: an overview.: AIDS Clin Rev. 1995-96;:47-63. Unique Identifier : AIDSLINE MED/96089197; Jacobson MA; University of California-San Francisco, USA.
Pathogenesis and management of HIV-associated drug hypersensitivity.: AIDS Clin Rev. 1995-96;:65-97. Unique Identifier : AIDSLINE MED/96089198; Carr A; Cooper DA; Centre for Immunology, St. Vincent's Hospital, Sydney, Australia.
Cytomegalovirus retinitis in AIDS: natural history, diagnosis, and treatment.: AIDS Clin Rev. 1995-96;:99-129. Unique Identifier : AIDSLINE MED/96089199; Dunn JP; Jabs DA; Johns Hopkins University School of Medicine, Baltimore, Maryland,; USA.; Cytomegalovirus retinitis is the most common intraocular infection and the leading cause of blindness in patients with AIDS. Diagnosis is made on clinical grounds; a variety of other infectious and neoplastic retinitides should be considered in the differential diagnosis. Treatment with intravenous ganciclovir or fosc
Cytomegalovirus retinitis in an AIDS patient without severe depletion in CD4 cell count [letter]: Br J Ophthalmol. 1995 Oct;79(10):962-3. Unique Identifier : AIDSLINE MED/96096111; Baglivo E; Dosso A; Leuenberger PM; Jelk L
Alterations in lymphocyte subsets as prognosticators of postoperative infections.: Eur J Surg. 1995 Jul;161(7):493-9. Unique Identifier : AIDSLINE MED/96026958; Gennari R; Dominioni L; Imperatori A; Bianchi V; Maroni P; Dionigi R; Department of Surgery, University of Pavia in Varese, Ospedale; Multizonale, Italy.; OBJECTIVE: To evaluate changes in lymphocyte subsets after major abdominal and thoracic operations, and to correlate changes with the development of clinically relevant infections postoperatively. DESIGN: Open study. SETTING: University hospital, Italy . SUBJECTS: 33 patients who wer
Recombinant granulocyte-macrophage colony-stimulating factor in the treatment of HIV-related leucopenia.: Acta Paediatr. 1995 Aug;84(8):943-4. Unique Identifier : AIDSLINE MED/96051001; Manfredi R; Cariani T; Latini F; Chiodo F; Istituto Malattie Infettive, Universita di Bologna, Italy.
Recent advances. Obstetrics.: BMJ. 1995 Nov 4;311(7014):1209-12. Unique Identifier : AIDSLINE MED/96069035; Steer P; Academic Department of Obstetrics and Gynaecology, Charing Cross; and Westminster Medical School, Chelsea and Westminster Hospital,; London.
Is there a moral obligation not to infect others?: BMJ. 1995 Nov 4;311(7014):1215-7. Unique Identifier : AIDSLINE MED/96069038; Harris J; Holm S; Centre for Social Ethics and Policy, University of Manchester.; The emergence of HIV infection and AIDS has refocused concern on the obligations surrounding the carrying and transmission of communicable diseases. This article asks three related questions: Is there a general duty not to spread contagion? Are there special obligations not to communicate disease in the workplace? And
[Detection of HIV virus antibodies in saliva]: Epidemiol Mikrobiol Imunol. 1995 Sep;44(3):127-9. Unique Identifier : AIDSLINE MED/96084472; Bruckova M; Stankova M; Centrum AIDS, Infekcni klinika 1. lekarske fakulty; Univerzity Karlovy, Fakultni nemocnice na Bulovce, Praha.; The authors evaluate the use of saliva as alternative biological material for detection of HIV antibodies. If collected properly and when using the appropriate ELISA methods, HIV antibodies can be assessed in saliva with considerable sensitivity and specificity. Testing in saliva eliminates many disadvantages found wh
Case of bilateral non-Hodgkin's lymphoma after dental extractions in a patient with the human immunodeficiency virus.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Sep;80(3):293-6. Unique Identifier : AIDSLINE MED/96087849; Hartwig A; Lilly J; Sarasin D; Department of Oral and Maxillofacial Surgery, College of; Dentistry, University of Iowa, Iowa City, USA.; It has long been known that immunocompromised patients have an increased risk of getting malignant neoplasms, with lymphomas predominating. This increase in lymphomas is especially notable in the population infected with the human immunodeficiency virus (HIV). Before the outbreak of the human immunodeficiency virus th
The neuropeptide alpha-melanocyte-stimulating hormone: a key component of neuroimmunomodulation.: Neuroimmunomodulation. 1994 Mar-Apr;1(2):93-9. Unique Identifier : AIDSLINE MED/96053018; Catania A; Lipton JM; First Medical Clinic, University of Milan, Italy.; Recent research indicates that the proopiomelanocortin derivative alpha-melanocyte stimulating hormone (alpha-MSH) is a significant modulator of host reactions including fever and inflammation. Although the precise mechanism of action is still unknown, cytokine antagonism is believed to be responsible for at least a p
Alpha-melanocyte-stimulating hormone suppresses antigen-stimulated T cell production of gamma-interferon.: Neuroimmunomodulation. 1994 May-Jun;1(3):188-94. Unique Identifier : AIDSLINE MED/96053032; Taylor AW; Streilein JW; Cousins SW; Schepens Eye Research Institute, Boston, MA 02114, USA.; The neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) is known to suppress cytokine-mediated inflammation. In addition, we previously found that alpha-MSH suppressed the production of the proinflammatory cytokine interferon (IFN)-gamma by antigen-stimulated primed lymph node T cells. This immunosuppressive
Viral load: to treat or not to treat? [news]: Nat Med. 1995 Oct;1(10):980. Unique Identifier : AIDSLINE MED/96071617; Steele FR
India refining simple HIV test [news]: Nat Med. 1995 Oct;1(10):984. Unique Identifier : AIDSLINE MED/96071618; Jayaraman KS
Confusion reigns over compassionate use of AIDS drug [news]: Nat Med. 1995 Oct;1(10):986. Unique Identifier : AIDSLINE MED/96071619; Tastemain C
HIV: the more things change, the more they stay the same.: Nat Med. 1995 Oct;1(10):991-3. Unique Identifier : AIDSLINE MED/96071621; Osborn JE; School of Public Health, University of Michigan, Ann Arbor 48109,; USA.
Sterilizing dental equipment [letter; comment]: Nat Med. 1995 Dec;1(12):1223-5. Unique Identifier : AIDSLINE MED/96083607; Muscarella LF
AIDS summit approaches [news]: Nat Med. 1995 Dec;1(12):1230. Unique Identifier : AIDSLINE MED/96083612; Steele FR
Finding new uses for thalidomide [news]: Nat Med. 1995 Dec;1(12):1230. Unique Identifier : AIDSLINE MED/96083611; Gershon D
The CD4/CD8 ratio: message in a bottle? [comment]: Nat Med. 1995 Dec;1(12):1240-1. Unique Identifier : AIDSLINE MED/96083615; Chakravarti A; Department of Genetics, Case Western Reserve University,; Cleveland, Ohio 44106, USA.
Clarifying the causes of Crohn's.: Nat Med. 1995 Dec;1(12):1241-3. Unique Identifier : AIDSLINE MED/96083616; Targan SR; Murphy LK; Cedars-Sinai Inflammatory Bowel Disease Center, Los Angeles,; California 90048, USA.
Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells.: Nat Med. 1995 Dec;1(12):1274-8. Unique Identifier : AIDSLINE MED/96083627; Boshoff C; Schulz TF; Kennedy MM; Graham AK; Fisher C; Thomas A; McGee JO; Weiss RA; O'Leary JJ; Virology Laboratory, Royal Marsden Hospital, London, UK.; Kaposi s sarcoma (KS), a vascular tumour that contains characteristic spindle cells forming slit-like spaces, may have an infectious aetiology. Recently, sequences of a new human herpesvirus, KSHV/HHV-8, have been identified in both HIV-associated and classical KS. We sought to identify the target cell of this virus i
Genetic control of the CD4/CD8 T-cell ratio in humans [see comments]: Nat Med. 1995 Dec;1(12):1279-83. Unique Identifier : AIDSLINE MED/96083628; Amadori A; Zamarchi R; De Silvestro G; Forza G; Cavatton G; Danieli GA; Clementi M; Chieco-Bianchi L; Institute of Oncology, Interuniversity Center for Research on; Cancer, University of Padova, Italy.; We studied the genetic pattern of inheritance of the ratio between circulating CD4+ and CD8+ T lymphocytes in a population of healthy donors. The distribution of the CD4/CD8 ratio in males and females was significantly different and was significantly affected by age. In 46 randomly selected families, the parental CD4/
In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency.: Nat Med. 1995 Dec;1(12):1284-90. Unique Identifier : AIDSLINE MED/96083629; Chun TW; Finzi D; Margolick J; Chadwick K; Schwartz D; Siliciano RF; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, Maryland 21205, USA.; Although it is presumed that the integration of HIV-1 into the genome of infected CD4+ T lymphocytes allows viral persistence, there has been little direct evidence that CD4+ T cells with integrated provirus function as a latent reservoir for HIV-1 in infected individuals. Using resting CD4+ T-cell populations of extr
Infection of human tonsil histocultures: a model for HIV pathogenesis.: Nat Med. 1995 Dec;1(12):1320-2. Unique Identifier : AIDSLINE MED/96083635; Glushakova S; Baibakov B; Margolis LB; Zimmerberg J; Laboratory of Theoretical and Physical Biology, National; Institute of Child Health and Human Development, National; Institutes of Health, Bethesda, Maryland 20892, USA.
Dissecting protein:protein interactions between transcription factors with an RNA aptamer.: RNA. 1995 May;1(3):317-26. Unique Identifier : AIDSLINE MED/96079963; Tian Y; Adya N; Wagner S; Giam CZ; Green MR; Ellington AD; Department of Chemistry, Indiana University, Bloomington 47405,; USA.; Nucleic acid aptamers isolated from random sequence pools have generally proven useful at inhibiting the interactions of nucleic acid binding proteins with their cognate nucleic acids. In order to develop reagents that could also be used to study protein:protein interactions, we have used in vitro selection to search
Identification of ribozymes within a ribozyme library that efficiently cleave a long substrate RNA.: RNA. 1995 Aug;1(6):598-609. Unique Identifier : AIDSLINE MED/96079988; Campbell TB; Cech TR; Howard Hughes Medical Institute, Department of Chemistry and; Biochemistry, University of Colorado, Boulder 80309-0215, USA.; Positions 2-6 of the substrate-binding internal guide sequence (IGS) of the L-21 Sca I form of the Tetrahymena thermophila intron were mutagenized to produce a GN5 IGS library. Ribozymes within the GN5 library capable of efficient cleavage of an 818-nt human immunodeficiency virus type 1 vif-vpr RNA, at 37 degrees C,
Voluntary anonymous linked study of the prevalence of HIV infection and hepatitis C among inmates in a Canadian federal penitentiary for women.: Can Med Assoc J. 1995 Dec 1;153(11):1605-9. Unique Identifier : AIDSLINE MED/96088804; Ford PM; White C; Kaufmann H; MacTavish J; Pearson M; Ford S; Sankar-Mistry P; Connop P; Department of Medicine, Queen's University, Kingston, ON.; OBJECTIVE: To determine the seroprevalence of HIV infection and hepatitis C among inmates of a federal penitentiary for women. DESIGN: Voluntary, anonymous, linked, point-prevalence study involving testing of blood samples for antibodies to HIV and hepatitis C virus. PARTICIPANTS: All inmates of the multilevel securit
HIV: evolution of a pandemic [editorial]: Can Med Assoc J. 1995 Dec 1;153(11):1613-6. Unique Identifier : AIDSLINE MED/96088805; Hankins C; Although the prevalence of AIDS is still relatively low in many countries in Asia and the Pacific Rim, the rate of HIV transmission in this region continues to rise inexorably and will surpass that of sub-Saharan Africa by 1997. The challenge of mobilizing governments and communities to counter this largely invisible
Cryptococcal pneumonia in patients with the acquired immunodeficiency syndrome.: Clin Radiol. 1995 Nov;50(11):756-60. Unique Identifier : AIDSLINE MED/96080101; Friedman EP; Miller RF; Severn A; Williams IG; Shaw PJ; Department of Imaging, University College London Hospitals (NHS); Trust, UK.; Infection with Cryptococcus neoformans occurs with increased frequency in patients with the human immunodeficiency virus (HIV). Despite the lungs being the portal of entry for the fungus the commonest presentation is with meningitis: Cryptococcal broncho pulmonary infection occurs less commonly. The chest radiographs
A sonographic-pathological correlation of liver biopsies in patients with the acquired immune deficiency syndrome (AIDS).: Clin Radiol. 1995 Nov;50(11):761-4. Unique Identifier : AIDSLINE MED/96080102; Beale TJ; Wetton CW; Crofton ME; Department of Radiology, St Mary's Hospital, London, UK.; The liver is commonly involved in patients with AIDS and a first line investigation for hepatic dysfunction is liver ultrasound (US) which is often abnormal. It is unclear how these US abnormalities correlate with the underlying pathological processes. A retrospective study was performed in 48 patients with HIV diseas
The reduced expression of endogenous duplications (REED) in the maize R gene family is mediated by DNA methylation.: EMBO J. 1995 Nov 1;14(21):5318-28. Unique Identifier : AIDSLINE MED/96080167; Ronchi A; Petroni K; Tonelli C; Dipartimento di Genetica e di Biologia dei microrganismi, Milano,; Italy.; The duplicated R and Sn genes regulate the maize anthocyanin biosynthetic pathway and encode tissue-specific products that are homologous to helix-loop-helix transcriptional activators. As a consequence of their coupling in the genome, Sn is partially silenced. Genomic restriction analysis failed to reveal gross struc
Differences in the interleukin-2 (IL-2) receptor system in human and mouse: alpha chain is required for formation of the functional mouse IL-2 receptor.: Eur J Immunol. 1995 Nov;25(11):3001-5. Unique Identifier : AIDSLINE MED/96085167; Nemoto T; Takeshita T; Ishii N; Kondo M; Higuchi M; Satomi S; Nakamura M; Mori S; Sugamura K; Department of Microbiology, Tohoku University School of Medicine,; Sendai, Japan.; Reconstitution with mouse interleukin-2 ( IL-2 ) receptor subunits demonstrated that the mouse IL-2 receptor complex was different from the human complex in the alpha chain requirement for the functional mouse receptor complex. The heterotrimeric complex of the mouse exo
Major histocompatibility complex class I-restricted CD8+ T cells and class II-restricted CD4+ T cells, respectively, mediate and regulate contact sensitivity to dinitrofluorobenzene.: Eur J Immunol. 1995 Nov;25(11):3006-10. Unique Identifier : AIDSLINE MED/96085168; Bour H; Peyron E; Gaucherand M; Garrigue JL; Desvignes C; Kaiserlian D; Revillard JP; Nicolas JF; INSERM U.80, Universite Claude Bernard Lyon I, Faculte A.; Carrel, France.; Contact sensitivity (CS) is a form of delayed-type hypersensitivity to haptens applied epicutaneously and is thought to be mediated, like classical delayed-type hypersensitivity responses, by CD4+ T helper-1 cells. The aim of this study was to identify the effector T cells involved in CS. We studied CS to the strongly
Modulation of immunity to Borrelia burgdorferi by ultraviolet irradiation: differential effect on Th1 and Th2 immune responses.: Eur J Immunol. 1995 Nov;25(11):3017-22. Unique Identifier : AIDSLINE MED/96085170; Brown EL; Rivas JM; Ullrich SE; Young CR; Norris SJ; Kripke ML; Department of Immunology, University of Texas M.D. Anderson; Cancer Center, Houston 77030, USA.; Ultraviolet B (UVB) radiation suppresses the delayed-type hypersensitivity (DTH) response to alloantigen by a mechanism involving interleukin (IL)-10. It has been hypothesized, based on this result, that UV irradiation shifts the immune response from a Th1 to a Th2 response. We tested this hypothesis using Borrelia bu
Preferential dependence of autoantibody production in murine lupus on CD86 costimulatory molecule.: Eur J Immunol. 1995 Nov;25(11):3060-9. Unique Identifier : AIDSLINE MED/96085177; Nakajima A; Azuma M; Kodera S; Nuriya S; Terashi A; Abe M; Hirose S; Shirai T; Yagita H; Okumura K; Department of Immunology, Juntendo University School of Medicine,; Tokyo, Japan.; Blockade of the interactions between CD28/CTLA-4 and their ligands, CD80 (B7, B7.1)/CD86 (B70, B7.2), seems an attractive means to induce antigen-specific peripheral tolerance in organ transplantation and autoimmune disease. Recently, diversities between CD80 and CD86 in expression, regulation, and function have been
Naive CD4+ T cells confer idiotype-specific tumor resistance in the absence of antibodies.: Eur J Immunol. 1995 Nov;25(11):3079-86. Unique Identifier : AIDSLINE MED/96085179; Bogen B; Munthe L; Sollien A; Hofgaard P; Omholt H; Dagnaes F; Dembic Z; Lauritzsen GF; Institute of Immunology and Rheumatology, University of Oslo,; Norway.; CD4+ T cells can recognize a processed idiotypic peptide derived from the mouse lambda 2(315) immunoglobulin light chain. The idiotypic peptide is presented on the I-E(d) class II major histocompatibility complex molecule. Mice made transgenic for a lambda 2(315)-specific alpha beta T cell receptor have been demonstra
Exacerbated autoimmunity associated with a T helper-1 cytokine profile shift in H-2E-transgenic mice.: Eur J Immunol. 1995 Nov;25(11):3134-41. Unique Identifier : AIDSLINE MED/96085187; Takacs K; Douek DC; Altmann DM; Clinical Sciences Centre, Royal Postgraduate Medical School,; Hammersmith Hospital, London, GB.; Major histocompatibility complex (MHC) class II genes are the strongest susceptibility markers for many human autoimmune diseases. A perplexing aspect of this is that HLA alleles can confer either susceptibility or dominant protection. In nonobese diabetic (NOD) mice, the strongest known diabetes susceptibility locus
AIDS related information, attitudes and behaviours among Italian male young people.: Eur J Epidemiol. 1995 Feb;11(1):23-31. Unique Identifier : AIDSLINE MED/96104931; Carducci A; Frasca M; Grasso A; Terzi I; Avio CM; Department of Experimental, Infective and Public Biomedicine,; University of Pisa, Italy.; In order to evaluate the AIDS related sources of information, knowledge, attitudes and behaviours among male young people it was filled in a multi-choice anonymous questionnaire by 2018 subjects, called for the first medical examination to Italian Navy and by 1348 recruits. The data from the latter group were used to
High prevalence of human T-lymphotropic virus (HTLV) infection in pregnant women in southern France [letter]: Eur J Epidemiol. 1995 Feb;11(1):93-4. Unique Identifier : AIDSLINE MED/96104942; Vignoli C; De Lamballerie X; Zandotti C; De Chesse R; Tamalet C; De Micco P
Prevalence of oral lesions in symptomatic and asymptomatic HIV patients.: Gen Dent. 1994 Sep-Oct;42(5):446-50. Unique Identifier : AIDSLINE MED/96104720; Little JW; Melnick SL; Rhame FS; Balfour HH Jr; Decher L; Rhodus NL; Merry JW; Walker PO; Miller CE; Volberding P; University of Minnesota, School of Dentistry, Minneapolis, MN; 55455, USA.
[DNA polymorphism of the BoLA-DRB3 gene in cattle in connection with resistance and susceptibility to leukemia]: Genetika. 1995 Sep;31(9):1294-9. Unique Identifier : AIDSLINE MED/96067854; Sulimova GE; Udina IG; Shaikhaev GO; Zakharov IA; Polymorphism of exon 2 of the BoLA-DRB3 gene was investigated by the PCR-RFLP method in a sample of healthy and leukemia-afflicted Black Pied cattle. Allele variety was studied and allele frequencies were determined in a total sample and in the two groups. Alleles mediating resistance (BoLA-DRB3.2*11, *23, and *28) an
Loss of CD4 T lymphocytes in patients infected with human immunodeficiency virus type 1 is more pronounced in the duodenal mucosa than in the peripheral blood. Berlin Diarrhea/Wasting Syndrome Study Group.: Gut. 1995 Oct;37(4):524-9. Unique Identifier : AIDSLINE MED/96097882; Schneider T; Jahn HU; Schmidt W; Riecken EO; Zeitz M; Ullrich R; Department of Medicine, Klinikum Benjamin Franklin, Free; University of Berlin.; Although changes in T lymphocyte subset distribution in the peripheral blood of patients infected with human immunodeficiency virus (HIV) are well defined it is not known whether these changes reflect changes in lymphoid compartments clearly involved in HIV related disease like the intestinal mucosa. This study analys
Drug induced acute pancreatitis: incidence and severity.: Gut. 1995 Oct;37(4):565-7. Unique Identifier : AIDSLINE MED/96097888; Lankisch PG; Droge M; Gottesleben F; Department of Internal Medicine, Municipal Hospital of Luneburg,; Germany.; To determine the incidence and severity of drug induced acute pancreatitis, data from 45 German centres of gastroenterology were evaluated. Among 1613 patients treated for acute pancreatitis in 1993, drug induced acute pancreatitis was diagnosed in 22 patients (incidence 1.4%). Drugs held responsible were azathioprine
Efficacy and safety of a monoclonal purified factor VIII concentrate: 5-year follow-up in previously treated HIV-negative haemophiliacs.: Haemostasis. 1995 Sep-Oct;25(5):229-36. Unique Identifier : AIDSLINE MED/96022610; Smid WM; van der Meer J; Halie MR; Department of Haematology, University Hospital Groningen, The; Netherlands.; The efficacy and safety of a monoclonal purified factor VIII concentrate (Hemofil M) were assessed in a historically controlled study in 22 HIV-negative patients with haemophilia A, previously treated with various concentrates. Data from 5 years of follow-up were compared with those from the preceding 6 months. Factor
Similar serological response to conventional therapy for syphilis among HIV-positive and HIV-negative women.: Genitourin Med. 1995 Oct;71(5):275-9. Unique Identifier : AIDSLINE MED/96096203; Goeman J; Kivuvu M; Nzila N; Behets F; Edidi B; Gnaore E; Van Dyck E; St. Louis M; Piot P; Laga M; Projet SIDA, Ministry of Health, Kinshasa, Zaire.; OBJECTIVES--To compare characteristics of syphilis serological reactivity in HIV positive (+) and HIV negative (-) female sex workers, as well as the serological response to therapy after treatment with intramuscular benzathine penicillin, 2.4 million U weekly, for three consecutive weeks. METHODS--Rapid plasma reagin
Open lung biopsy for investigation of acute respiratory episodes in patients with HIV infection and AIDS.: Genitourin Med. 1995 Oct;71(5):280-5. Unique Identifier : AIDSLINE MED/96096204; Miller RF; Pugsley WB; Griffiths MH; Department of Medicine, University College London Medical School,; UK.; BACKGROUND--Open lung biopsy (OLB) is rarely necessary for investigation of HIV positive patients with acute respiratory episodes because of the high yield from fibreoptic bronchoscopy with bronchoalveolar lavage (BAL). METHODS--A retrospective review of OLB in HIV positive patients admitted to a specialist inpatient
Trends in female sexual behaviour and sexually transmitted diseases in London, 1982-1992.: Genitourin Med. 1995 Oct;71(5):286-90. Unique Identifier : AIDSLINE MED/96096205; Evans BA; McCormack SM; Kell PD; Parry JV; Bond RA; MacRae KD; Department of Genitourinary Medicine, Charing Cross Hospital,; London, UK.; OBJECTIVE--To measure changes in female sexual behaviour, including condom use, and their relationship with the incidence of sexually transmitted and other genital diseases in women during the decade 1982-92. DESIGN--A prospective series of cross-sectional surveys of sexual behaviour reported by a standardised self-ad
Disseminated cutaneous Mycobacterium tuberculosis infection in a patient with AIDS.: Genitourin Med. 1995 Oct;71(5):308-10. Unique Identifier : AIDSLINE MED/96096210; Corbett EL; Crossley I; De Cock KM; Miller RF; HIV/AIDS Unit, Camden and Islington Community Health Services NHS; Trust, Middlesex Hospital, London, UK.; Individuals infected with the human immunodeficiency virus (HIV) are at an increased risk of both pulmonary and extrapulmonary tuberculosis. Disseminated cutaneous tuberculosis is rare, but has been reported in four HIV-positive patients, all of whom also had pulmonary infection. In this report we describe an HIV-infe
HIV infection and maternal outcome of pregnancy in Mozambican women: a case-control study [letter]: Genitourin Med. 1995 Oct;71(5):323-4. Unique Identifier : AIDSLINE MED/96096213; Bergstrom S; Sonnerborg A; Osman NB; Libombo A
Antiretroviral monotherapies and serum HIV-1 dynamics [letter]: Genitourin Med. 1995 Oct;71(5):324-5. Unique Identifier : AIDSLINE MED/96096214; Loveday C
Failure of itraconazole to prevent Enterocytozoon bieneusi infection [letter]: Genitourin Med. 1995 Oct;71(5):325-6. Unique Identifier : AIDSLINE MED/96096215; Albrecht H; Stellbrink HJ; Sobottka I
Patients' awareness of changes in the Association of British Insurers' guidelines on HIV testing [letter]: Genitourin Med. 1995 Oct;71(5):332-3. Unique Identifier : AIDSLINE MED/96096222; Newell A; Rogers L; Barton SE
Pneumococcal vaccine and HIV infection [letter; comment]: Genitourin Med. 1995 Oct;71(5):336. Unique Identifier : AIDSLINE MED/96096229; Griffiths M
Pseudomonas aeruginosa infections and HIV [letter; comment]: Genitourin Med. 1995 Oct;71(5):336. Unique Identifier : AIDSLINE MED/96096228; Moore D; Nelson M
Sensitization of MHC class I-restricted T cells to exogenous proteins: evidence for an alternative class I-restricted antigen presentation pathway.: Immunology. 1995 Oct;86(2):287-95. Unique Identifier : AIDSLINE MED/96096250; Martinez-Kinader B; Lipford GB; Wagner H; Heeg K; Institute for Medical Microbiology and Hygiene, Technical; University of Munich, Germany.; Immunization with exogenous proteins usually fails to immunize CD8+ T cells in vivo. Here we report that chicken ovalbumin (OVA) denatured by heat or sodium dodecyl sulphate (SDS) effectively induced CD8+ cytolytic T cells in vivo. The cytolytic T-lymphocyte (CTL) population generated recognized syngeneic target cells
Posterior uveitis in the acquired immunodeficiency syndrome.: Int Ophthalmol Clin. 1995 Spring;35(2):1-14. Unique Identifier : AIDSLINE MED/96037246; McCluskey PJ; Wakefield D; University of New South Wales, Department of Ophthalmology, St.; Vincent's Hospital, Sydney, Australia.
Human T-lymphotropic virus type 1 and its ocular manifestations.: Int Ophthalmol Clin. 1995 Spring;35(2):107-20. Unique Identifier : AIDSLINE MED/96037253; Mochizuki M; Department of Ophthalmology, Kurume University School of; Medicine, Fukuoka, Japan.
Ocular toxoplasmosis: toxoplasmic retinochoroiditis.: Int Ophthalmol Clin. 1995 Spring;35(2):15-29. Unique Identifier : AIDSLINE MED/96037247; Tabbara KF; Department of Ophthalmology, College of Medicine, King Saud; University, King Faisal Specialist Hospital and Research Center,; Riyadh, Saudi Arabia.
Calcium requirement and inhibitor spectrum for intracellular HIV type 1 gp160 processing in cultured HeLa cells and CD4+ lymphocytes: similarity to those of viral envelope glycoprotein maturase.: J Biochem (Tokyo). 1995 Jun;117(6):1244-53. Unique Identifier : AIDSLINE MED/96104996; Kamoshita K; Shiota M; Sasaki M; Koga Y; Okumura Y; Kido H; Division of Enzyme Chemistry, University of Tokushima.; We recently purified the calcium-independent processing protease named viral envelope glycoprotein maturase (VEM), that converts human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein precursor gp160 to gp120 and gp41, from the human CD4+ T cell line, Molt-4 clone 8 [Kido, H., Kamoshita, K., Fukutomi, A., a
Down-regulation of Epstein-Barr virus nuclear antigen 1 in Reed-Sternberg cells of Hodgkin's disease.: J Clin Pathol. 1995 Sep;48(9):845-8. Unique Identifier : AIDSLINE MED/96096274; Khan G; Naase MA; Department of Pathology, Tufts University School of Medicine,; Boston, MA 02111, USA.; AIMS--To demonstrate Epstein-Barr virus (EBV) encoded nuclear antigen 1 (EBNA-1) gene expression in EBV associated disorders using a new monoclonal antibody (1H4-1) on routinely processed tissues. METHODS--The pressure cooker antigen retrieval method was used for the immunohistochemical demonstration of EBNA-1 gene ex
Management of blood donors whose donations are repeatedly falsely positive by the HIV antibody screening test.: J Clin Pathol. 1995 Sep;48(9):865-7. Unique Identifier : AIDSLINE MED/96096278; Atrah HI; Parry JV; Gough D; Tosswill J; Ala FA; West Midlands Regional Blood Transfusion Service, Edgbaston,; Birmingham.; Since 1985, over 1,800,000 donations have been screened by the West Midlands Regional Blood Transfusion Service for antibody to HIV. Twelve regular donors gave three or more donations that were alternatingly positive and negative in the screening test, but not confirmed to be HIV positive by supplementary testing. Ext
Human papillomavirus DNA in nonanogenital keratoacanthoma and squamous cell carcinoma of patients with HIV infection.: J Am Acad Dermatol. 1995 Dec;33(6):1047-9. Unique Identifier : AIDSLINE MED/96095123; Payne D; Newman C; Tyring S; Department of Microbiology and Immunology, University of Texas; Medical Branch, Galveston 77555-1019, USA.
Epidermal expression of 65 and 72 kd heat shock proteins in psoriasis and AIDS-associated psoriasiform dermatitis.: J Am Acad Dermatol. 1995 Dec;33(6):985-9. Unique Identifier : AIDSLINE MED/96095113; Puig L; Fernandez-Figueras MT; Ferrandiz C; Ribera M; de Moragas JM; Department of Dermatology, Hospital de la Santa Creu i Sant Pau,; Barcelona, Spain.; BACKGROUND: Psoriasiform dermatitis is common in patients with AIDS. The expression of heat shock proteins by keratinocytes has been postulated to be a significant factor in the physiopathology of psoriasis and might be subject to modulation in HIV-infected patients. OBJECTIVE: We sought to evaluate the epidermal expr
Dry eye among males infected with the human immunodeficiency virus.: J Am Optom Assoc. 1995 Sep;66(9):533-8. Unique Identifier : AIDSLINE MED/96033481; DeCarlo DK; Penner SL; Schamerloh RJ; Fullard RJ; School of Optometry, University of Alabama at Birmingham 35294,; USA.; BACKGROUND: Keratoconjunctivitis sicca (KCS) has been reported as a potential ocular manifestation of human immunodeficiency virus (HIV) infection. This study was designed to estimate prevalence of dry eye among HIV-infected males and correlate subjective and objective findings with disease severity. METHODS: All subj
The newer macrolides. Azithromycin and clarithromycin.: Infect Dis Clin North Am. 1995 Sep;9(3):731-45. Unique Identifier : AIDSLINE MED/96087611; Zuckerman JM; Kaye KM; Temple University School of Medicine, Philadelphia, Pennsylvania,; USA.; Azithromycin and clarithromycin are structural analogues of erythromycin that have similar mechanisms of action. The newer macrolides have several distinct advantages over erythromycin, including improved oral bioavailability; longer half-life, allowing once or twice daily administration; higher tissue concentrations;
Characterization of mouse nasal lymphocytes isolated by enzymatic extraction with collagenase.: J Immunol Methods. 1995 Nov 16;187(1):41-51. Unique Identifier : AIDSLINE MED/96085237; Asanuma H; Inaba Y; Aizawa C; Kurata T; Tamura S; Department of Pathology, National Institute of Health, Tokyo,; Japan.; A reproducible method for isolation of mouse nasal lymphocytes was developed. The cells were released from tissue fragments of dissected mouse nose by enzyme extraction with collagenase and separated by a stepwise Percoll gradient centrifugation. The partially purified nasal lymphocyte fraction from normal BALB/c mice
Immediate-type hypersensitivity response followed by a late reaction is induced by repeated epicutaneous application of contact sensitizing agents in mice.: J Invest Dermatol. 1995 Dec;105(6):749-55. Unique Identifier : AIDSLINE MED/96086840; Kitagaki H; Fujisawa S; Watanabe K; Hayakawa K; Shiohara T; Department of Dermatology, Kyorin University School of Medicine,; Tokyo, Japan.; Repeated administration of antigen often leads to consequences different from those expected with fewer encounters with the antigen, but little attention has been paid to the effects of repeated epicutaneous application of antigens. To investigate whether repeated epicutaneous application of a contact-sensitizing agen
Th2 cytokine profile in cutaneous T-cell lymphoma [letter; comment]: J Invest Dermatol. 1995 Dec;105(6):855-6. Unique Identifier : AIDSLINE MED/96086856; Lessin SR; Vowels BR; Rook AH
Type I insulin-like growth factor receptor expression in different developmental stages of human thymocytes.: J Endocrinol. 1995 Nov;147(2):203-9. Unique Identifier : AIDSLINE MED/96096292; Kooijman R; Scholtens LE; Rijkers GT; Zegers BJ; Department of Immunology, University Hospital for Children and; Youth Het Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands.; Insulin-like growth factor-I (IGF-I) has been implicated in playing a regulatory role in T cell development and in T cell function. We demonstrate the presence of type I IGF receptors on human thymocytes using radioligand binding assays and flowcytometric analysis. The relative potencies of IGF-I, IGF-II and insulin f
Two-step development of Hashimoto-like thyroiditis in genetically autoimmune prone non-obese diabetic mice: effects of iodine-induced cell necrosis.: J Endocrinol. 1995 Nov;147(2):311-20. Unique Identifier : AIDSLINE MED/96096304; Many MC; Maniratunga S; Varis I; Dardenne M; Drexhage HA; Denef JF; Laboratory of Histology, Catholic University of Louvain, Medical; School, Brussels, Belgium.; The administration of a high iodide dose (HID; 10 micrograms/day) to goitrous mice is known to induce thyroid cell necrosis and inflammation, which, in most strains, is transient. In this study, we analyzed the effects of iodide in autoimmune prone non-obese diabetic (NOD) mice. Control NOD mice fed a standard diet (M
Prolactin receptor expression in lymphocytes from patients with hyperprolactinemia or acromegaly.: J Endocrinol. 1995 Nov;147(2):353-9. Unique Identifier : AIDSLINE MED/96096308; Leite-de-Moraes MC; Touraine P; Kelly PA; Kuttenn F; Dardenne M; Universite Rene Descartes, Paris V, CNRS URA 1461, Hopital; Necker, Paris, France.; Previous reports demonstrated that prolactin receptors (PRL-R) are widely expressed on cells of the immune system. We analyzed a possible regulation of PRL-R expression on human mononucleated blood cells by prolactin (PRL) itself. PRL-R expression was analyzed by immunofluorescence on T and B lymphocytes and monocytes
Prolonged survival of mice with glioma injected intracerebrally with double cytokine-secreting cells.: J Neurosurg. 1995 Dec;83(6):1038-44. Unique Identifier : AIDSLINE MED/96086871; Lichtor T; Glick RP; Kim TS; Hand R; Cohen EP; Division of Neurosurgery, Cook County Hospital, Chicago,; Illinois, USA.; A novel approach toward the treatment of glioma was developed in a murine model. The genes for both interleukin-2 ( IL-2 ) and interferon-gamma (IFN-gamma) were first transfected into a mouse fibroblast cell line that expresses defined major histocompatibility complex (M
A controlled study of anxiety and morbid cognitions at initial screening for human immunodeficiency virus (HIV) in a cohort of people with haemophilia.: J Psychosom Res. 1995 Jul;39(5):597-608. Unique Identifier : AIDSLINE MED/96058809; Jones QJ; Garsia RJ; Wu RT; Job RF; Dunn SM; Medical Psychology Unit, University of Sydney, Australia.; AIM. This study examines the relationship between anxiety, psychological state and Human Immunodeficiency Virus (HIV) stages as defined by the Centers for Disease Control at the time of initial screening for HIV in a cohort of people with haemophilia who were at risk of prior exposure to HIV transmission from blood pr
Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. 4. 2-Substituted dipyridodiazepinones as potent inhibitors of both wild-type and cysteine-181 HIV-1 reverse transcriptase enzymes.: J Med Chem. 1995 Nov 24;38(24):4830-8. Unique Identifier : AIDSLINE MED/96083811; Proudfoot JR; Hargrave KD; Kapadia SR; Patel UR; Grozinger KG; McNeil DW; Cullen E; Cardozo M; Tong L; Kelly TA; et al; Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield,; Connecticut 06877, USA.; The major cause of viral resistance to the potent human immunodeficiency virus type 1 reverse transcriptase (RT) inhibitor nevirapine is the mutation substituting cysteine for tyrosine-181 in RT (Y181C RT). An evaluation, against Y181C RT, of previous
Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase. 5. 4-Substituted and 2,4-disubstituted analogs of nevirapine.: J Med Chem. 1995 Nov 24;38(24):4839-47. Unique Identifier : AIDSLINE MED/96083812; Kelly TA; Proudfoot JR; McNeil DW; Patel UR; David E; Hargrave KD; Grob PM; Cardozo M; Agarwal A; Adams J; Research and Development Center, Boehringer Ingelheim; Pharmaceuticals Inc., Ridgefield, Connecticut 06877, USA.; Molecular modeling analysis of the recently published X-ray crystal structure of nevirapine bound to wild type human immunodeficiency virus type 1 reverse transcriptase (WT-RT) indicated the presence of a lipophilic cavity proximal to the 4-position o
Tat functions to stimulate the elongation properties of transcription complexes paused by the duplicated TAR RNA element of human immunodeficiency virus 2.: J Mol Biol. 1995 Dec 1;254(3):350-63. Unique Identifier : AIDSLINE MED/96095795; Garcia-Martinez LF; Mavankal G; Peters P; Wu-Baer F; Gaynor RB; Department of Medicine, University of Texas Southwestern Medical; Center at Dallas 75235, USA.; In this study we have defined the in vitro requirements for transcriptional regulation of the HIV-2 LTR in response to the HIV-1 and HIV-2 Tat proteins and addressed potential mechanisms of Tat function. HIV-2 contains a duplicated TAR RNA stem-loop structure in contrast to the single stem-loop structure found in HIV-
CDR walking mutagenesis for the affinity maturation of a potent human anti-HIV-1 antibody into the picomolar range.: J Mol Biol. 1995 Dec 1;254(3):392-403. Unique Identifier : AIDSLINE MED/96095799; Yang WP; Green K; Pinz-Sweeney S; Briones AT; Burton DR; Barbas CF 3rd; Department of Molecular Biology, Scripps Research Institute, La; Jolla, CA 92037, USA.; We describe the investigation of methodologies for the creation of very high affinity human antibodies. The high affinity human antibody b4/12 was optimized for its affinity to the human envelope glycoprotein gp120 of human immunodeficiency virus type 1 (HIV-1). Five libraries of b4/12 were constructed by saturation m
Re: Fournier's gangrene as the presenting sign of an undiagnosed human immunodeficiency virus infection [letter; comment]: J Urol. 1996 Jan;155(1):291-2. Unique Identifier : AIDSLINE MED/96094566; Hotter JT
Renal lymphoma and human immunodeficiency virus infection [letter; comment]: Mayo Clin Proc. 1995 Dec;70(12):1224-5. Unique Identifier : AIDSLINE MED/96086926; Navarro JF; Liano F
[the early diagnosis of the vertical transmission of the human immunodeficiency virus type 1. The evaluation of diagnostic tests]: Med Clin (Barc). 1995 Oct 14;105(12):446-9. Unique Identifier : AIDSLINE MED/96077784; Cruz Garcia M; de Jose I; Hawkins F; Bates I; Martinez Zapico R; Ferreira A; Fontan G; Unidad de Inmunologia, Hospital La Paz, Madrid.; BACKGROUND: The early diagnosis of vertically transmitted human immunodeficiency virus infection cannot be based on the presence of specific serum antibodies since those of the maternal IgG class pass the placenta and may be detected in children for up to 18 months. Based on this fact, the aim of this study was to eva
[The risk factors in death from heroin (editorial; comment)]: Med Clin (Barc). 1995 Oct 14;105(12):455-6. Unique Identifier : AIDSLINE MED/96077786; Cami J; Domingo-Salvany A
[A cystic lymphoepithelial lesion of the parotid in HIV-1-infected patients]: Med Clin (Barc). 1995 Oct 14;105(12):461-3. Unique Identifier : AIDSLINE MED/96077788; Calderon-Osuna E; Vinuesa M; Fernandez-Machin P; Mendoza E; Gallardo JA; Pineda JA; Departamento de Medicine Interna, Hospital Universitario Virgen; del Rocio, Sevilla.; Cystic lymphoepithelial lesion is an infrequent disorder involving the saliva glands mainly the parotid gland; however, its frequency has increased coinciding with the epidemics of HIV-1 infection. Three cases of parotid lymphoepithelial lesion in patients with HIV-1 infection, 2 of whom were hemophiliacs and one an e
[The sexual transmission of zidovudine-resistant HIV-1 strains (letter)]: Med Clin (Barc). 1995 Oct 14;105(12):476-7. Unique Identifier : AIDSLINE MED/96077792; Ruiz L; Clotet B
[Apropos the prevention of the vertical transmission of HIV (letter)]: Med Clin (Barc). 1995 Oct 14;105(12):477-8. Unique Identifier : AIDSLINE MED/96077793; Casabona J; Rodes A
An HIV-1-positive child with fever and a scalp nodule.: Lancet. 1995 Dec 2;346(8988):1466. Unique Identifier : AIDSLINE MED/96081993; Malane MS; Laude TA; Chen CK; Fikrig S; Department of Dermatology, State University of New York Health; Science Centre, Brooklyn 11203-2098, USA.
Drug prevents SIV infection [news]: Lancet. 1995 Dec 2;346(8988):1482. Unique Identifier : AIDSLINE MED/96081998; McCarthy M
Impact of treatment and prophylaxis on presentation and survival of patients with AIDS in Milan [letter]: Lancet. 1995 Dec 2;346(8988):1488. Unique Identifier : AIDSLINE MED/96082005; Monforte A; Mainini F; Musicco M; Formenti T; Mena M; Bini T; Moroni M
HIV prevalence among pregnant women in Kigali, Rwanda [letter]: Lancet. 1995 Dec 2;346(8988):1488-9. Unique Identifier : AIDSLINE MED/96082006; Leroy V; Ntawiniga P; Nziyumvira A; Kagubare J; Salamon R
Genetic diversity and HIV detection by PCR [letter; comment]: Lancet. 1995 Dec 2;346(8988):1489. Unique Identifier : AIDSLINE MED/96082007; Clewley JP
Assessing suffering [letter]: Lancet. 1995 Dec 2;346(8988):1492. Unique Identifier : AIDSLINE MED/96082014; Bayes R; Limonero JT; Barreto P; Comas MD
Preventing HIV transmission in prison: a tale of medical disobedience and Swiss pragmatism.: Lancet. 1995 Dec 9;346(8989):1507-8. Unique Identifier : AIDSLINE MED/96094599; Nelles J; Harding T; Psychiatrische Universitatsklinik, Bern, Switzerland.
AIDS education dollars cause upset in Texas [news]: Lancet. 1995 Dec 9;346(8989):1548. Unique Identifier : AIDSLINE MED/96094611; Firshein J
Factors that suppress HIV uncovered [news]: Lancet. 1995 Dec 9;346(8989):1551. Unique Identifier : AIDSLINE MED/96094612; Thompson C
Role of the TATA box in transcription of the mouse mammary tumor virus long terminal repeat.: Mol Endocrinol. 1995 Sep;9(9):1180-92. Unique Identifier : AIDSLINE MED/96064300; Kusk P; Carlson KE; Warren BS; Hager GL; Laboratory of Molecular Virology, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892, USA.; An in vitro transcription system from mammary cells was established to study transcription of the long terminal repeat (LTR) of the mouse mammary tumor virus (MMTV). Experiments with progressive 5 -deletion constructs of the MMTV LTR revealed that a 19-base pair (bp) region from -41 to -23 bp, encompassing the TATA bo
Estimated risk of transmission of the human immunodeficiency virus by screened blood in the United States.: N Engl J Med. 1995 Dec 28;333(26):1721-5. Unique Identifier : AIDSLINE MED/96092302; Lackritz EM; Satten GA; Aberle-Grasse J; Dodd RY; Raimondi VP; Janssen RS; Lewis WF; Notari EP 4th; Petersen LR; HIV Seroepidemiology Branch, Centers for Disease Control and; Prevention, Atlanta, GA 30333, USA.; BACKGROUND. In the United States , transmission of the human immunodeficiency virus (HIV) by blood transfusion occurs almost exclusively when a recently infected blood donor is infectious but before antibodies to HIV become detectable (during the window period). We estimated the risk of
Early treatment of HIV infection [letter; comment]: N Engl J Med. 1995 Dec 28;333(26):1782; discussion 1783. Unique Identifier : AIDSLINE MED/96092321; Fessel WJ
Early treatment of HIV infection [letter; comment]: N Engl J Med. 1995 Dec 28;333(26):1782; discussion 1783. Unique Identifier : AIDSLINE MED/96092322; Schwartz DH
Early treatment of HIV infection [letter; comment]: N Engl J Med. 1995 Dec 28;333(26):1783. Unique Identifier : AIDSLINE MED/96092323; Cates W Jr; Cohen MS
Atypical and equivocal sonographic features of the spinal cord in neonates.: Pediatr Radiol. 1995;25(6):429-32. Unique Identifier : AIDSLINE MED/96071232; Rypens F; Avni EF; Matos C; Pardou A; Struyven J; Department of Radiology, Hospital Erasme, Universite Libre de; Bruxelles, Belgium.; Thanks to the wider use of sonography to examine the spinal content in the neonate, normal anatomy and anomalies may be detected easily. Yet, unusual sonographic patterns are also observed. These must be differentiated from true pathologies. During a prospective study of 103 neurologically asymptomatic neonates, atypi
Annual summary of vital statistics-1994.: Pediatrics. 1995 Dec;96(6):1029-39. Unique Identifier : AIDSLINE MED/96095150; Guyer B; Strobino DM; Ventura SJ; Singh GK; Department of Maternal and Child Health, Johns Hopkins School of; Hygiene and Public Health, Baltimore, MD 21205, USA.; Recent trends in the vital statistics of the United States continued in 1994, including decreases in the number of births, the birth rate, the age-adjusted death rate, and the infant mortality rate. Life expectancy increased slightly to 75.7 years. Only marriages reversed the recent tr
Psychological response to HIV positivity in hemophilia.: Pediatrics. 1995 Dec;96(6):1062-9. Unique Identifier : AIDSLINE MED/96095155; Drotar DD; Agle DP; Eckl CL; Thompson PA; Department of Psychiatry, Case Western Reserve, University School; of Medicine, USA.; OBJECTIVE. To compare the psychological and family adaptation of children and adolescents with hemophilia who were seropositive for human immunodeficiency virus type 1 (HIV-1) with an HIV-negative group of comparable age, demographic characteristics, and disease severity in a multi-site study. DESIGN. Cross-sectional,
Neurological correlates of fetal cocaine exposure: transient hypertonia of infancy and early childhood.: Pediatrics. 1995 Dec;96(6):1070-7. Unique Identifier : AIDSLINE MED/96095156; Chiriboga CA; Vibbert M; Malouf R; Suarez MS; Abrams EJ; Heagarty MC; Brust JC; Hauser WA; Department of Neurology, College of Physicians and Surgeons,; Columbia University, New York, New York 10032, USA.; OBJECTIVE. To assess whether prenatal cocaine exposure has any long-term effects on neurodevelopment. DESIGN. A prospective cohort study with examiners blind to drug exposure and human immunodeficiency virus (HIV) status. SUBJECTS. Of 144 high-risk infants enrolled in a perinatal HIV neurodevelopmental study, 119 (83%
The effects of HIV on cognitive and motor development in children born to HIV-seropositive women with no reported drug use: birth to 24 months.: Pediatrics. 1995 Dec;96(6):1078-82. Unique Identifier : AIDSLINE MED/96095157; Gay CL; Armstrong FD; Cohen D; Lai S; Hardy MD; Swales TP; Morrow CJ; Scott GB; Department of Pediatrics, University of Miami School of Medicine,; FL 33101, USA.; OBJECTIVE. This study documents delays in the mental and motor functioning of infants perinatally infected with human immunodeficiency virus (HIV) while controlling for confounding effects of prenatal drug exposure, ethnicity, socioeconomic status, and maternal separation and death. METHODS. The cognitive and motor de
Failure to identify human immunodeficiency virus-seropositive newborns: epidemiology and enrollment patterns in a predominantly white, nonurban setting.: Pediatrics. 1995 Dec;96(6):1083-9. Unique Identifier : AIDSLINE MED/96095158; Coplan J; Dye TD; Contello KA; Cunningham CK; Kirkwood K; Weiner LB; Department of Pediatrics, State University of New York-Health; Science Center at Syracuse 13210, USA.; OBJECTIVE. To describe the epidemiology of newborn seroprevalence for human immunodeficiency virus (HIV) in a predominantly white, nonurban population, and to determine the factors associated with enrollment at a regional pediatric acquired immunodeficiency syndrome (AIDS) center serving that population. DESIGN. Retro
The prevalence of sexually transmitted diseases in children and adolescents evaluated for sexual abuse in Cincinnati: rationale for limited STD testing in prepubertal girls.: Pediatrics. 1995 Dec;96(6):1090-4. Unique Identifier : AIDSLINE MED/96095159; Siegel RM; Schubert CJ; Myers PA; Shapiro RA; Division of General Pediatrics, Children's Hospital Medical; Center, Cincinnati, OH, USA.; OBJECTIVE. To determine the prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, syphilis, and human immunodeficiency virus (HIV) infection in sexually abused children and to develop selective criteria for sexually transmitted disease (STD) testing in these children in our community. DESI
[Neuropsychological development of children born to HIV-positive mothers]: Pediatr Med Chir. 1995 Jul-Aug;17(4):331-3. Unique Identifier : AIDSLINE MED/96093231; Piazza F; Astori MG; Maccabruni A; Caselli D; Bossi G; Lanzi G; Istituto Neurologico C. Mondino di Pavia, Italia.; 138 children born to HIV infected mothers (58 HIV infected and 80 seroreverted uninfected) were followed up at the Institute of Infectious Diseases of the University of Pavia. All patients had an evaluation of neurological assessment every three months done by a pediatric neurologist (Amiel-Tison and Towen) and an eva
[Prognostic markers in serum of active and passive intravenous drug users infected with human immunodeficiency virus (HIV)]: Pol Arch Med Wewn. 1995 Jun;93(6):469-74. Unique Identifier : AIDSLINE MED/96043344; Rogowska-Szadkowska D; Borzuchowska A; Prokopowicz D; Chodynicka B; Rogowski F; Kramarz P; Klinika Obserwacyjno-Zakazna.; The analyse of neopterin (NPT), beta 2-microglobulin (beta 2-M) and immunoglobulin A (IgA) in active and passive intravenous drug users was made to show the influence of intravenous drug taking on the level of so called prognostic markers in the serum of HIV infected persons. The intravenous drug users remained in the
[Tuberculosis in France: how can the current epidemic be stopped? Conference of Experts on Tuberculosis, 15 December 1994, Paris]: Rev Mal Respir. 1995;12 Suppl 3:R132-57. Unique Identifier : AIDSLINE MED/96053198; Begue P; Carbonnelle B; Cartier F; Chretien J; Delaval P; Dellamonica P; Desenclos JC; Durieux P; Lagrange PH; Leophonte P; et al
[Tuberculosis among AIDS patients in Ullev]l hospital]: Tidsskr Nor Laegeforen. 1995 Nov 10;115(27):3361-4. Unique Identifier : AIDSLINE MED/96097504; Berild D; Infeksjonsavdelingen Medisinsk klinikk, Oslo.; Records of patients with concomitant HIV infection and human tuberculosis were analysed. Nine out of 232 AIDS patients (4%) developed human tuberculosis with a preponderance (6/9) of immigrants from sub-Saharan Africa. In three patients the diagnosis was delayed because of atypical manifestations of the disease and la
Two strong 5' splice sites and competing, suboptimal 3' splice sites involved in alternative splicing of human immunodeficiency virus type 1 RNA.: Virology. 1995 Nov 10;213(2):373-85. Unique Identifier : AIDSLINE MED/96074513; O'Reilly MM; McNally MT; Beemon KL; Department of Biology, Johns Hopkins University, Baltimore,; Maryland 21218, USA.; The human immunodeficiency virus type 1 (HIV-1) genome contains 20 exons that are alternatively spliced from 16 splice sites to generate more than 40 different mRNAs, including incompletely spliced and unspliced mRNAs. In contrast to avian retroviral RNA, which has a cis-acting element in gag that negatively regulates
Characterization of a CD4-expressing macaque cell line that can detect virus after a single replication cycle and can be infected by diverse simian immunodeficiency virus isolates.: Virology. 1995 Nov 10;213(2):386-94. Unique Identifier : AIDSLINE MED/96074514; Chackerian B; Haigwood NL; Overbaugh J; Department of Microbiology, University of Washington, Seattle; 98195, USA.; Primate lentiviruses such as human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) are phenotypically diverse, and virus isolates vary in cytopathicity, replication rate, and cell tropism. While all virus isolates infect primary peripheral blood lymphocytes, only a subset of strains infect establi
HIV-1 Tat directly interacts with the interferon-induced, double-stranded RNA-dependent kinase, PKR.: Virology. 1995 Nov 10;213(2):413-24. Unique Identifier : AIDSLINE MED/96074517; McMillan NA; Chun RF; Siderovski DP; Galabru J; Toone WM; Samuel CE; Mak TW; Hovanessian AG; Jeang KT; Williams BR; Department of Cancer Biology, Cleveland Clinic Foundation, Ohio; 44195, USA.; We present evidence that the HIV-1 Tat protein and the RNA-dependent cellular protein kinase, PKR, interact with each other both in vitro and in vivo. Using GST fusion chromatography, we demonstrate that PKR, interacts directly with the HIV-1 Tat protein. The region in Tat sufficient for binding PKR maps within amino
Analysis of trafficking of Rev and transdominant Rev proteins in living cells using green fluorescent protein fusions: transdominant Rev blocks the export of Rev from the nucleus to the cytoplasm.: Virology. 1995 Nov 10;213(2):439-49. Unique Identifier : AIDSLINE MED/96074519; Stauber R; Gaitanaris GA; Pavlakis GN; Human Retrovirus Section, NCI-FCRDC, Maryland 21702-1201, USA.; Expression of gag/pol and env genes of human immunodeficiency virus requires the viral Rev protein. Mutant Rev proteins, displaying a transdominant phenotype (TDRev), were shown to inhibit Rev function. To investigate the underlying mechanism of this inhibition, the green fluorescent protein (GFP) of Aequorea victoria
HIV-1 mediates rapid apoptosis of lymphocytes from human CD4 transgenic but not normal rabbits.: Virology. 1995 Nov 10;213(2):450-4. Unique Identifier : AIDSLINE MED/96074520; Leno M; Hague BF; Teller R; Kindt TJ; Laboratory of Immunogenetics, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Rockville,; Maryland 20852, USA.; Normal rabbit lymphocytes can be infected with HIV-1 although infection is much less efficient than in human lymphocytes. When peripheral blood mononuclear cells (PBMC) from rabbits transgenic for human CD4 (HuCD4) were exposed to HIV-1, enhanced infection and a rapid depletion of lymphocytes were observed. Cell death
Limited viral spread and rapid immune response in lymph nodes of macaques inoculated with attenuated simian immunodeficiency virus.: Virology. 1995 Nov 10;213(2):535-48. Unique Identifier : AIDSLINE MED/96074529; Chakrabarti L; Baptiste V; Khatissian E; Cumont MC; Aubertin AM; Montagnier L; Hurtrel B; Unite d'Oncologie Virale, Institut Pasteur, Paris, France.; A comparative study was undertaken to characterize the very early events that distinguish attenuated and pathogenic simian immunodeficiency virus (SIV) infections. Three rhesus macaques were inoculated with the attenuated SIVmac 251 delta nef virus, and three others with a virus of intermediate phenotype, SIVmac 239 n
Lymphocyte-tropic simian immunodeficiency virus causes persistent infection in the brains of rhesus monkeys.: Virology. 1995 Nov 10;213(2):600-14. Unique Identifier : AIDSLINE MED/96074535; Stephens EB; Liu ZQ; Zhu GW; Adany I; Joag SV; Foresman L; Berman NE; Narayan O; Department of Microbiology, Molecular Genetics and Immunology,; Marion Merrell Dow Laboratory for Viral Pathogenesis, University; of Kansas Medical Center, Kansas City 66160-7240, USA.; Molecularly cloned SIVmac239 is the prototypical SIVmac lymphocyte-tropic virus that replicates productively in lymphocytes but poorly in macrophages. In macaques, the virus causes activation and productive infection of T lymphocytes which invade the central nervous system (CNS) early after infection in the animal. Ho
The human immunodeficiency virus type 1 Vpu protein: a potential regulator of proteolysis and protein transport in the mammalian secretory pathway.: Virology. 1995 Nov 10;213(2):639-49. Unique Identifier : AIDSLINE MED/96074538; Vincent MJ; Abdul Jabbar M; Department of Molecular Biology, Cleveland Clinic Foundation,; Ohio 44195, USA.; HIV-1 Vpu is a small transmembrane phosphoprotein of 16 kDa which performs critical roles in CD4 proteolysis and virus release. Previous studies have demonstrated that Vpu-induced degradation of CD4 occurs in the endoplasmic reticulum (ER), and that the proteolytic process is sequence specific requiring both the trans
Replication of molluscum contagiosum virus.: Virology. 1995 Nov 10;213(2):655-9. Unique Identifier : AIDSLINE MED/96074540; Buller RM; Burnett J; Chen W; Kreider J; Laboratory of Viral Diseases, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892, USA.; Molluscum contagiosum virus (MCV) infects preadolescent children and sexually active adults, frequently causing a disfiguring cutaneous disease in immunosuppressed HIV-infected individuals. The development of an efficacious treatment regime has been hampered by the failure to replicate the virus in the laboratory. Her
Analysis of human immunodeficiency virus type 1 integrase mutants.: Virology. 1995 Nov 10;213(2):680. Unique Identifier : AIDSLINE MED/96074545; Ansari-Lari MA; Donehower LA; Gibbs RA
Antibody and cytotoxic T-lymphocyte responses to a single liposome-associated peptide antigen.: Vaccine. 1995 Aug;13(12):1111-22. Unique Identifier : AIDSLINE MED/96088067; White WI; Cassatt DR; Madsen J; Burke SJ; Woods RM; Wassef NM; Alving CR; Koenig S; Department of Immunology, MedImmune Incorporated, Gaithersburg,; MD 20878, USA.; The development of peptide-based vaccines that elicit antibody (Ab) and cellular immune responses has been hampered by the lack of highly immunogenic formulations. In this study, we compared the induction of Ab and cytotoxic T-lymphocyte (CTL) responses to a peptide derived from the V3 loop of HIV-1 gp120 (P18 and its
[Partnership and sex behavior of consumers of illegal drugs: a survey of 654 persons in the open drug scene in Zurich]: Soz Praventivmed. 1995;40(5):285-97. Unique Identifier : AIDSLINE MED/96076559; Muller T; Abteilung fur Klinische Immunologie, Universitatsspital; Zurich.; In the spring of 1991, a survey was carried out in the open drug scene in Zurich s Platzspitz area with the objective of studying drug users behaviour with regard to relationships and sexuality, a random sample of 654 users (both male and female) of illegal drugs being interviewed and the data drawn from these interv
[AIDS prevention in European prisons]: Soz Praventivmed. 1995;40(5):298-301. Unique Identifier : AIDSLINE MED/96076560; Schaller G; Harding TW; Institut universitaire de medecine legale, Geneve.; Informations on HIV/AIDS in prisons which include 32 prison-systems in 17 European countries have been collected. The principle of equivalence of preventive measures and health care between prisons and the outside community, prison authorities should strive to prevent HIV transmission in prisons. There have been major
Hepatotoxicity of antibiotics.: Acta Gastroenterol Belg. 1995 May-Aug;58(3-4):290-6. Unique Identifier : AIDSLINE MED/96076758; Hautekeete ML; Department of Hepato-Gastroenterology, Free University of; Brussels (AZ-VUB), Belgium.; Several antibiotics can cause severe hepatic injury. It is the purpose of this paper to review the main antibiotics that can cause hepatic injury and discuss the presentation, pattern, and outcome of hepatic injury. In the case of the penicillins, the combination amoxycillin-clavulanate and the penicillinase-resistant
Long-chain polyunsaturated fatty acids in children with severe protein-energy malnutrition with and without human immunodeficiency virus-1 infection.: Am J Clin Nutr. 1995 Dec;62(6):1283-8. Unique Identifier : AIDSLINE MED/96094678; Decsi T; Zaknun D; Zaknun J; Sperl W; Koletzko B; Kinderpoliklinik, Ludwig-Maximilians-University, Munich, Germany.; Fatty acids in plasma phospholipids were studied in 35 severely malnourished young children with a median age of 29 mo (range: 9-43 mo), who were either seronegative for human immunodeficiency virus-1 (HIV) (n = 16) or suffered from asymptomatic (stage P-1; n = 12) or symptomatic (stage P-2; n = 7) HIV disease. The ma
SDZ PRI 053, an orally bioavailable human immunodeficiency virus type 1 proteinase inhibitor containing the 2-aminobenzylstatine moiety.: Antimicrob Agents Chemother. 1995 Jul;39(7):1406-13. Unique Identifier : AIDSLINE MED/96104872; Billich A; Fricker G; Muller I; Donatsch P; Ettmayer P; Gstach H; Lehr P; Peichl P; Scholz D; Rosenwirth B; Sandoz Research Institute, Vienna, Austria.; A series of inhibitors of human immunodeficiency virus type 1 (HIV-1) proteinase containing the 2-aralkyl-amino-substituted statine moiety as a novel transition-state analog was synthesized, with the aim to obtain compounds which combine anti-HIV potency with oral bioavailability. The reduced-size 2-aminobenzylstatine
Mechanism of inhibition of duck hepatitis B virus polymerase by (-)-beta-L-2',3'-dideoxy-3'-thiacytidine.: Antimicrob Agents Chemother. 1995 Jul;39(7):1430-5. Unique Identifier : AIDSLINE MED/96104876; Severini A; Liu XY; Wilson JS; Tyrrell DL; Glaxo Heritage Research Institute, Department of Medical; Microbiology and Infectious Diseases, University of Alberta,; Edmonton, Canada.; We have used the endogenous reverse transcriptase reaction of viral core particles from duck liver to elucidate the mechanism of inhibition of duck hepatitis B virus (DHBV) replication by the nucleoside analog (-)-beta-L-2 ,3 -dideoxy-3 -thiacytidine ( 3TC
Safety, pharmacokinetics, and antiviral activity of A77003, a C2 symmetry-based human immunodeficiency virus protease inhibitor.: Antimicrob Agents Chemother. 1995 Jul;39(7):1559-64. Unique Identifier : AIDSLINE MED/96104900; Reedijk M; Boucher CA; van Bommel T; Ho DD; Tzeng TB; Sereni D; Veyssier P; Jurriaans S; Granneman R; Hsu A; et al; Department of Internal Medicine (Clinical AIDS Unit), University; of Amsterdam, The Netherlands.; A77003, an inhibitor of the human immunodeficiency virus type 1 (HIV-1) protease, was administered to asymptomatic HIV-1-infected patients in a phase I trial. The drug was given by continuous intravenous infusion at dosages of 0.035, 0.07, 0.14, and 0.28 mg/kg of body weight per h. The drug was given first for 24 h an
Analysis of mutations at position 184 in reverse transcriptase of human immunodeficiency virus type 1.: Antimicrob Agents Chemother. 1995 Jul;39(7):1624-8. Unique Identifier : AIDSLINE MED/96104915; Boyer PL; Hughes SH; Advanced BioScience Laboratories-Basic Research Program, National; Cancer Institute-Frederick Cancer Research and Development; Center, Maryland 21702-1201, USA.; We have analyzed recombinant human immunodeficiency virus type 1 reverse transcriptases that contain mutations at position 184. These variants retain high levels of RNA-dependent DNA polymerase activity and show resistance to ddITP. However, the mutants varied in their ability to polymerize processively. The variants
A penile ulceration in a patient with the acquired immunodeficiency syndrome. Foscarnet-induced penile ulceration.: Arch Dermatol. 1995 Dec;131(12):1449, 1452. Unique Identifier : AIDSLINE MED/96094882; Fitzgerald E; Goldman HM; Miller WG; Purcell SM; Philadelphia College of Osteopathic Medicine, Pa, USA.
Amyopathic dermatomyositis [editorial; comment]: Arch Dermatol. 1995 Dec;131(12):1458-9. Unique Identifier : AIDSLINE MED/96094884; Kagen LJ
Proinflammatory cytokine production and cartilage damage due to rheumatoid synovial T helper-1 activation is inhibited by interleukin-4.: Ann Rheum Dis. 1995 Oct;54(10):836-40. Unique Identifier : AIDSLINE MED/96097726; van Roon JA; van Roy JL; Duits A; Lafeber FP; Bijlsma JW; Department of Rheumatology, University Hospital Utrecht, The; Netherlands.; OBJECTIVES--To investigate the role of T helper-1 cell (Th1) activation in the induction of proinflammatory cytokine production and cartilage damage by rheumatoid arthritis (RA) synovial fluid mononuclear cells (SFMNC) and the subsequent possible beneficial role of the T helper-2 cell (Th2) cytokine interleukin-4 (IL-
Treatment of refractory juvenile chronic arthritis by monoclonal CD4 antibodies: a pilot study in two children.: Ann Rheum Dis. 1995 Oct;54(10):846-9. Unique Identifier : AIDSLINE MED/96097728; Horneff G; Dirksen U; Schulze-Koops H; Emmrich F; Wahn V; Department of Paediatrics, University of Dusseldorf, Germany.; OBJECTIVE--To study the effect of anti-CD4 treatment in patients suffering from refractory systemic onset juvenile chronic arthritis (JCA). METHODS--Two children were treated with the mouse CD4 antibody MAX.16H5. The effects on numbers of circulating CD4 T cells, clinical symptoms and C reactive protein (CRP) level we
Primary vs secondary iliopsoas abscess. Presentation, microbiology, and treatment.: Arch Surg. 1995 Dec;130(12):1309-13. Unique Identifier : AIDSLINE MED/96094963; Santaella RO; Fishman EK; Lipsett PA; Department of Surgery, Johns Hopkins University School of; Medicine, Baltimore, Md, USA.; OBJECTIVE: To review the characteristics of patient presentation, microbiology, and treatment of primary iliopsoas abscess. DESIGN: A case series of patients with iliopsoas abscess diagnosed on computed tomographic scans from 1987 to 1994. SETTING: Tertiary care inner-city university hospital. PATIENTS: Eleven patient
A comparison of cerebral SPECT abnormalities in HIV-positive homosexual men with and without cognitive impairment.: Arch Neurol. 1995 Dec;52(12):1170-3. Unique Identifier : AIDSLINE MED/96094927; Sacktor N; Van Heertum RL; Dooneief G; Gorman J; Khandji A; Marder K; Nour R; Todak G; Stern Y; Mayeux R; Gertrude H. Sergievsky Center, Columbia University College of; Physicians and Surgeons, New York, NY, USA.; OBJECTIVE: To determine whether technetium Tc 99m exametazime (HMPAO) single-photon emission computed tomography (SPECT) can distinguish between human immunodeficiency virus (HIV)-positive homosexual men with normal neuropsychologic test results and HIV-positive homosexual men with abnormal neuropsychologic test resul
Risk of human immunodeficiency virus type 1-related neurologic disease in a cohort of intravenous drug users.: Arch Neurol. 1995 Dec;52(12):1174-82. Unique Identifier : AIDSLINE MED/96094928; Marder K; Liu X; Stern Y; Malouf R; Dooneief G; Bell K; Todak G; Joseph M; Sorrell S; el Sadr W; et al; Gertrude H. Sergievsky Center, New York, NY 10032, USA.; BACKGROUND: Although the proportion of cases of acquired immunodeficiency syndrome related to intravenous drug use has increased dramatically over the past decade, there has been no longitudinal examination of primary neurologic disease in this group. OBJECTIVE: To study the development of neurologic disease in human
2',3'-Dideoxycytidine metabolism in a new drug-resistant cell line.: Biochem J. 1995 Nov 15;312 ( Pt 1):115-23. Unique Identifier : AIDSLINE MED/96077134; Magnani M; Brandi G; Casabianca A; Fraternale A; Schiavano GF; Rossi L; Chiarantini L; Istituto di Chimica Biologica G. Fornaini, Universita degli; Studi di Urbino, Italy.; 2 ,3 -Dideoxycytidine ( ddC ) is a nucleoside analogue that inhibits human immunodeficiency virus type 1 (HIV-1) replication in vitro and is currently used in the therapy of acquired immune deficiency syndrome (AIDS). This compound exerts a delayed cyto
Lycorine alkaloids from Hymenocallis littoralis.: Phytochemistry. 1995 Nov;40(4):1295-8. Unique Identifier : AIDSLINE MED/96038661; Lin LZ; Hu SF; Chai HB; Pengsuparp T; Pezzuto JM; Cordell GA; Ruangrungsi N; Department of Medicinal Chemistry and Pharmacognosy, College of; Pharmacy, University of Illinois at Chicago 60612, USA.; From Hymenocallis littoralis, one new alkaloid, named littoraline, together with 13 known lycorine alkaloids and one lignan, were isolated. The structure and NMR assignments of this new alkaloid were determined by 1D and 2D NMR techniques. Littoraline showed inhibitory activity of HIV reverse transcriptase, and lycori
[An echocardiographic comparison of left ventricular function in HIV-virus carriers and infected patients in different stages of immunosuppression]: Rev Port Cardiol. 1995 Oct;14(10):725-8. Unique Identifier : AIDSLINE MED/96079710; Abreu A; Serrano A; Nunes H; Cardoso O; Oliveira M; Pitta L; Morgado A; Salomao S; Proenca R; Antunes AM; Hospital de Santa Marta.
Ebeltoft project: baseline data from a five-year randomized, controlled, prospective health promotion study in a Danish population.: Br J Gen Pract. 1995 Oct;45(399):542-7. Unique Identifier : AIDSLINE MED/96104321; Lauritzen T; Leboeuf-Yde C; Lunde IM; Nielsen KD; Nordic Institute for Chiropractic and Clinical Biomechanics,; Odense, Denmark.; BACKGROUND. There is increasing political pressure on the medical profession to approach welfare diseases, such as coronary heart disease and diabetes, through prevention. General practitioners are required to offer regular health checks to healthy people, in spite of the lack of scientific evidence for the universal
Acutely infected Langerhans cells are more efficient than T cells in disseminating HIV type 1 to activated T cells following a short cell-cell contact.: AIDS Res Hum Retroviruses. 1995 Aug;11(8):877-84. Unique Identifier : AIDSLINE MED/96020088; Ayehunie S; Groves RW; Bruzzese AM; Ruprecht RM; Kupper TS; Langhoff E; Laboratory of Viral Pathogenesis, Dana-Farber Cancer Institute,; Boston, Massachusetts 02115, USA.; Most human immunodeficiency virus type 1 (HIV-1) infections involve sexual contact and virus passage across mucosal surfaces. While Langerhans cells (LCs) and dendritic cells (DCs) have been implicated in mucosal infection, their role is undefined. Here we demonstrate that acutely HIV-1-infected LCs and DCs effectivel
Costimulation of CD4+ T cells via CD28 modulates human immunodeficiency virus type 1 infection and replication in vitro.: AIDS Res Hum Retroviruses. 1995 Aug;11(8):885-92. Unique Identifier : AIDSLINE MED/96020089; Smithgall MD; Wong JG; Linsley PS; Haffar OK; Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle,; Washington 98121, USA.; Stimulation of human immunodeficiency virus type 1 (HIV-1)-infected donor peripheral blood mononuclear cells (PBMCs) via the TCR-CD3 complex induces HIV-1 production in vitro (Zarling JM, et al.: Nature [London] 1990;347:92; Haffar OK, et al.: J Virol 1992;66:4279; Moran PM, et al.: AIDS Res Hum Retroviruses 1993;9:45
Transmembrane P-glycoprotein (P-gp/P-170) in HIV infection: analysis of lymphocyte surface expression and drug-unrelated function.: AIDS Res Hum Retroviruses. 1995 Aug;11(8):893-901. Unique Identifier : AIDSLINE MED/96020090; Lucia MB; Cauda R; Landay AL; Malorni W; Donelli G; Ortona L; Istituto Clinica delle Malattie Infettive, Universita Cattolica; del Sacro Cuore, Rome, Italy.; P-glycoprotein (P-gp/P-170), a transmembrane efflux pump known to be one of the mechanisms responsible for multidrug resistance in cancer therapy, is constitutively expressed in several solid human tissues as well as in normal peripheral blood lymphocytes and bone marrow cells. In particular, this molecule has been as
Gag-specific cytotoxic responses to HIV type 1 are associated with a decreased risk of progression to AIDS-related complex or AIDS.: AIDS Res Hum Retroviruses. 1995 Aug;11(8):903-7. Unique Identifier : AIDSLINE MED/96020091; Riviere Y; McChesney MB; Porrot F; Tanneau-Salvadori F; Sansonetti P; Lopez O; Pialoux G; Feuillie V; Mollereau M; Chamaret S; et al; URA CNRS 1157 Departement des Retrovirus, Institut Pasteur,; Paris, France.; The duration of human immunodeficiency virus (HIV-1) infection prior to the development of AIDS is variable, and for most patients the exact time of infection is not known. A group of 38 HIV-1-infected subjects was tested while asymptomatic for comparative cytotoxic lymphocyte responses to the Gag and envelope antigen
Highly attenuated HIV type 2 recombinant poxviruses, but not HIV-2 recombinant Salmonella vaccines, induce long-lasting protection in rhesus macaques.: AIDS Res Hum Retroviruses. 1995 Aug;11(8):909-20. Unique Identifier : AIDSLINE GENBANK/J04498; Franchini G; Robert-Guroff M; Tartaglia J; Aggarwal A; Abimiku A; Benson J; Markham P; Limbach K; Hurteau G; Fullen J; et al; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892, USA.; Immunization schemes employing priming with vector-based vaccine candidates followed by subunit booster administrations have been explored and shown to have merit in the human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus systems. In this study, we have assessed the priming capacity of highly
Cytokine-containing liposomes as adjuvants for HIV subunit vaccines.: AIDS Res Hum Retroviruses. 1995 Aug;11(8):921-32. Unique Identifier : AIDSLINE MED/96020093; Lachman LB; Shih LC; Rao XM; Hu X; Bucana CD; Ullrich SE; Cleland JL; Department of Cell Biology, University of Texas M.D. Anderson; Cancer Center, Houston 77030, USA.; Dehydration-rehydration liposome vesicles (DRVs) containing various cytokines were evaluated for their ability to induce delayed-type hypersensitivity (DTH) and humoral immunity to the recombinant envelope protein rgp120 of the MN strain of human immunodeficiency virus type 1 (HIV-1). The DRVs trapped approximately 25
Induction of potent humoral and cell-mediated immune responses following direct injection of DNA encoding the HIV type 1 env and rev gene products.: AIDS Res Hum Retroviruses. 1995 Aug;11(8):933-43. Unique Identifier : AIDSLINE MED/96020094; Okuda K; Bukawa H; Hamajima K; Kawamoto S; Sekigawa K; Yamada Y; Tanaka S; Ishi N; Aoki I; Nakamura M; Department of Bacteriology, Yokohama City University School of; Medicine, Japan.; DNA vaccines have the potential of giving rise to a potent cell-mediated immune response by inducing intracellular synthesis and subsequent antigenic presentation of encoded antigens. We have tested a DNA vaccine specific for human immunodeficiency virus type 1 (HIV-1) by the injection of animals with expression plasm
Expression and purification of the HIV type 1 Rev protein produced in Escherichia coli and its use in the generation of monoclonal antibodies.: AIDS Res Hum Retroviruses. 1995 Aug;11(8):945-53. Unique Identifier : AIDSLINE MED/96020095; Orsini MJ; Thakur AN; Andrews WW; Hammarskjold ML; Rekosh D; Department of Biochemistry, University at Buffalo, New York; 14214, USA.; We have developed a simple and rapid procedure for the purification of large amounts of Rev protein overexpressed in E. coli. The purification method, which does not require denaturation of the protein, takes advantage of the positively charged nature of Rev and the ability of Rev to interact with nucleic acids. The p
Simian immunodeficiency virus infection of macaque primary placental cells.: AIDS Res Hum Retroviruses. 1995 Aug;11(8):955-61. Unique Identifier : AIDSLINE MED/96020096; Bui T; Watanabe R; Kennedy B; Unadkat JD; Morton WR; Ho RJ; Department of Pharmaceutics, University of Washington, Seattle; 98195, USA.; We have characterized the ability of a simian immunodeficiency virus, SIVmne strain E11S, to infect macaque placental trophoblast and Hofbauer cells. These primary placental cells were permissive to SIVmne infection, regardless of gestational age. Virus production by the infected cells was determined as time-dependent
Studies of complement-activating antibodies in the SIV/macaque model of acute primary infection and vaccine protection.: AIDS Res Hum Retroviruses. 1995 Aug;11(8):963-70. Unique Identifier : AIDSLINE MED/96020097; Montefiori DC; Reimann KA; Letvin NL; Zhou J; Hu SL; Department of Surgery, Duke University Medical Center, Durham,; North Carolina 27710, USA.; Questions regarding the potential impact of complement-activating antibodies on lentivirus pathogenesis and vaccine development were addressed in the SIV/macaque model by evaluating sera for activity related to complement-mediated, antibody-dependent enhancement (C -ADE) of SIV infection in vitro. C -ADE activity in s
HIV glycoprotein 41 and complement factor H interact with each other and share functional as well as antigenic homology.: AIDS Res Hum Retroviruses. 1995 Aug;11(8):971-80. Unique Identifier : AIDSLINE MED/96020098; Pinter C; Siccardi AG; Lopalco L; Longhi R; Clivio A; Dipartimento di Biologia e Genetica per le Scienze Mediche,; L.I.T.A. Vialba, Universita degli Studi di Milano, Italy.; We have shown that complement factor H (CFH) interacts with HIV-1 at the level of the sequence Env 105-119, contained in the C1 domain of gp120. CFH interaction with HIV was evident only after dissociation of the Env complex induced by exposure to sCD4. We hypothesized that CFH could act as a gp41 analog in the intera
Molecular characterization of an HIV type 1 isolate from Burundi.: AIDS Res Hum Retroviruses. 1995 Aug;11(8):981-4. Unique Identifier : AIDSLINE GENBANK/L35459; Ranjbar S; Slade A; Jenkins A; Heath A; Kitchin P; Almond N; Osmanov S; Holmes H; National Institute for Biological Standard and Control, AIDS; Collaborating Centre, South Mimms, Potters Bar, UK.
Increased risk for a second retroviral infection (SIV or STLV type I) for wild African green monkeys already infected by one retrovirus in Senegal (West Africa).: AIDS Res Hum Retroviruses. 1995 Aug;11(8):985-8. Unique Identifier : AIDSLINE MED/96020100; Durand JP; Tuppin P; Maison P; Galat G; Galat-Luong A; Jeannel D; De The G; Institut de Medecine Tropicale du Service de Sante des Armees,; Marseille, France.
A new HTLV type II subtype A isolate in an HIV type 1-infected prostitute from Cameroon, Central Africa.: AIDS Res Hum Retroviruses. 1995 Aug;11(8):989-93. Unique Identifier : AIDSLINE GENBANK/Z46837; Mauclere P; Mahieux R; Garcia-Calleja JM; Salla R; Tekaia F; Millan J; De The G; Gessain A; Centre Pasteur du Cameroun, Yaounde.; Among 332 female sex workers in Douala, Cameroon , 113 were HIV-1 seropositive, 3 were HTLV-I seropositive, and only 1 had specific anti-HTLV-II antibodies. By cocultivation with BJAB cells, an HTLV-II was isolated from the peripheral blood mononuclear cells of this 32-year-old wo
Yet another subtype of HIV type 1?: AIDS Res Hum Retroviruses. 1995 Aug;11(8):995-7. Unique Identifier : AIDSLINE GENBANK/L41179; Leitner T; Alaeus A; Marquina S; Lilja E; Lidman K; Albert J; Department of Clinical Virology, Swedish Institute for Infectious; Disease Control/Karolinska Institute, Stockholm, Sweden.
HIV type 1 sequence subtype G transmission from mother to infant: failure of variant sequence species to amplify in the Roche Amplicor Test.: AIDS Res Hum Retroviruses. 1995 Aug;11(8):999-1001. Unique Identifier : AIDSLINE GENBANK/U26307; Arnold C; Barlow KL; Kaye S; Loveday C; Balfe P; Clewley JP; Hepatitis and Retrovirus Laboratory, Central Public Health; Laboratory, London, United Kingdom.
AIDS-related behaviour in adolescents: intervention programme with international application.: Br J Clin Pract. 1995 Sep-Oct;49(5):229-31. Unique Identifier : AIDSLINE MED/96086128; Nikolopoulos TP; Gamatsi IE; Lioumi DE; Apostolopoulos NJ; Department of Pediatrics, Kyriakou Children's Hospital, Athens,; Greece.; Adolescents and young adults compromise one of the fastest-growing categories of AIDS cases. The results of an opinion survey taken of 3242 adolescents raise serious doubts about the prevalent view that high-risk behaviour is attributable to insufficient information and education on AIDS: female adolescents are found
Hepatitis and HIV: interrelationship and interactions.: Br J Clin Pract. 1995 Sep-Oct;49(5):247-51. Unique Identifier : AIDSLINE MED/96086134; Newell A; Francis N; Nelson M; HIV/GUM Unit, Chelsea & Westminster Hospital, London.; Hepatitis in the context of HIV infection is commonplace, but the causative agent is not always readily identifiable. This review highlights the differential diagnosis of hepatitis in that context, examining the interrelationships and interactions between the four main hepatitis viruses and HIV.
C. albicans septic arthritis in a patient with AIDS.: Br J Clin Pract. 1995 Sep-Oct;49(5):270-1. Unique Identifier : AIDSLINE MED/96086140; Smith NA; Keat AC; Barton SE; HIV/Genitourinary Medicine Unit, Chelsea and Westminster; Hospital, London.
Munchausen's syndrome (HIV infection): a trap for the unwary.: Br J Clin Pract. 1995 Sep-Oct;49(5):271-2. Unique Identifier : AIDSLINE MED/96086141; Harry TC; Ong EL; Department of Genito-Urinary Medicine, Sunderland District; General Hospital.
Hydroxyquinones are competitive non-peptide inhibitors of HIV-1 proteinase.: Biochim Biophys Acta. 1995 Nov 15;1253(1):5-8. Unique Identifier : AIDSLINE MED/96085082; Brinkworth RI; Fairlie DP; Centre for Drug Design and Development, University of Queensland,; Brisbane, Australia.; Quinones with one, two and three aromatic rings are a new class of micromolar non-peptidic inhibitors of HIV-1 proteinase, an enzyme essential for replication of Human Immunodeficiency Virus and an important drug target for AIDS. Substituted anthraquinones bearing hydroxyl substituents on one of their three rings were
Effect of administration of serum thymic factor (FTS) in calves and rabbits infected with bovine immunodeficiency-like virus.: J Vet Med Sci. 1995 Apr;57(2):307-10. Unique Identifier : AIDSLINE MED/96114695; Hirai N; Furuyama H; Awaya A; Onuma M; Department of Epizootiology, Faculty of Veterinary Medicine,; Hokkaido University, Japan.; The effect of serum thymic factor (FTS) administration in bovine immunodeficiency-like virus (BIV)-infected calves and rabbits was examined. We previously found that some of the macrophage functions were depressed and humoral immune responses against foreign proteins were delayed in BIV-infected calves compared to uni
Radioimmunotherapy of interleukin-2R alpha-expressing adult T-cell leukemia with Yttrium-90-labeled anti-Tac.: Blood. 1995 Dec 1;86(11):4063-75. Unique Identifier : AIDSLINE MED/96082159; Waldmann TA; White JD; Carrasquillo JA; Reynolds JC; Paik CH; Gansow OA; Brechbiel MW; Jaffe ES; Fleisher TA; Goldman CK; et al; Metabolism Branch, National Cancer Institute, National Institutes; of Health, Bethesda, MD 20892, USA.; Adult T-cell leukemia (ATL) is a malignancy of mature lymphocytes caused by the retrovirus human T-cell lymphotropic virus-I. It is an aggressive leukemia with a median survival time of 9 months; no chemotherapy regimen appears successful in inducing long-term disease-free survival. The scientific basis of the present
Detection of cytomegalovirus DNA in CD34+ cells from blood and bone marrow.: Blood. 1995 Dec 1;86(11):4086-90. Unique Identifier : AIDSLINE MED/96082161; von Laer D; Meyer-Koenig U; Serr A; Finke J; Kanz L; Fauser AA; Neumann-Haefelin D; Brugger W; Hufert FT; Abteilung Virologie, Universitat Freiburg, Germany.; Infection of hematopoietic progenitor cells with the human cytomegalovirus (HCMV) has been proposed as an explanation for the cytopenias associated with HCMV-related disease. To test this hypothesis, CD34+ cells, which include the hematopoietic progenitors, as well as mature leukoc
Spontaneous and glucocorticoid-induced apoptosis in human mature T lymphocytes.: Blood. 1995 Dec 1;86(11):4199-205. Unique Identifier : AIDSLINE MED/96082175; Brunetti M; Martelli N; Colasante A; Piantelli M; Musiani P; Aiello FB; Department of Human Pathology, G. D'Annunzio University, Chieti,; Italy.; Glucocorticoid (GC)-induced apoptosis is a well-recognized physiologic regulator of murine T-cell number and function. We have analyzed its mechanisms in human mature T cells, which have been thought to be insensitive until recently. Peripheral blood T cells showed sensitivity to GC-induced apoptosis soon after the pr
Characterization of T cells immortalized by Tax1 of human T-cell leukemia virus type 1.: Blood. 1995 Dec 1;86(11):4243-9. Unique Identifier : AIDSLINE MED/96082180; Akagi T; Ono H; Shimotohno K; Virology Division, National Cancer Center Research Institute,; Tokyo, Japan.; Peripheral blood T cells were immortalized in vitro by introduction of the Tax1 gene of human T-cell leukemia virus type 1 (HTLV-1) with a retroviral vector and were characterized for transformation-associated markers. Long-term observation showed that these Tax1-immortalized T cells eventually exhibited very similar
CD8-depleted donor lymphocyte infusion as treatment for relapsed chronic myelogenous leukemia after allogeneic bone marrow transplantation.: Blood. 1995 Dec 1;86(11):4337-43. Unique Identifier : AIDSLINE MED/96082192; Giralt S; Hester J; Huh Y; Hirsch-Ginsberg C; Rondon G; Seong D; Lee M; Gajewski J; Van Besien K; Khouri I; et al; Department of Hematology, University of Texas M.D. Anderson; Cancer Center, Houston 77031, USA.; Donor lymphocyte infusions can reinduce complete remission in the majority of patients with chronic myelogenous leukemia (CML) who relapse into chronic phase after allogeneic bone marrow transplantation (BMT). Such infusions are associated with a high incidence of graft-versus-host disease (GVHD) and marrow aplasia. B
Chloroquine treatment affects T-cell priming to minor histocompatibility antigens and graft-versus-host disease.: Blood. 1995 Dec 1;86(11):4344-52. Unique Identifier : AIDSLINE MED/96082193; Schultz KR; Bader S; Paquet J; Li W; Department of Pediatrics, University of British Columbia,; Vancouver, Canada.; Graft-versus-host disease (GVHD) caused by T-cell recognition of minor histocompatibility (MiHC) antigens is a major complication of bone marrow transplantation. GVHD therapy has focused on removal or suppression of donor T cells, but modulation of MiHC antigen presentation to CD4+ T cells may represent an alternative
In utero transfer of adult bone marrow cells into recipients with severe combined immunodeficiency disorder yields lymphoid progeny with T- and B-cell functional capabilities.: Blood. 1995 Dec 1;86(11):4353-66. Unique Identifier : AIDSLINE MED/96082194; Blazar BR; Taylor PA; Vallera DA; Department of Pediatrics, University of Minnesota Hospital,; Minneapolis 55455, USA.; To determine if in utero transplantation could restore the immune system of mice with a severe combined immunodeficiency (SCID) disorder, C57BL/6Sz-scid/scid fetuses were injected on day 14/15 of gestation with adult congenic donor bone marrow (BM) cells. Congenic BM engrafted in one of eight (13%) recipients. Reconst
Safe sex in the era of AIDS.: Trends Health Care Law Ethics. 1995 Summer;10(3):27-33. Unique Identifier : AIDSLINE MED/96088364; Money J; The term masturbation entered the English language in 1776 in the translation of Tissot s Treatise on the Diseases Produced by Onanism. Tissot linked semen conservation theory from antiquity with degeneracy theory and attributed degeneration and death from the social disease (syphilis and gonorrhea) to semen wastage n
Non Hodgkin's lymphoma of the maxilla as a first clinical manifestation of HIV infection. Report of a case.: Bull Group Int Rech Sci Stomatol Odontol. 1995 Sep-Oct;38(3-4):77-80. Unique Identifier : AIDSLINE MED/96045858; Berberi A; Mokhbat J; Nasseh I; Zeinoun T; Section of Oral Pathology, Dental School, Lebanese University,; Beirut, Lebanon.; Non-Hodgkin s lymphoma (NHL) of the oral cavity is rare. When it occurs, one should be suspicious of infection with the human immunodeficiency virus (HIV). NHL is the second most common malignancy associated with the acquired immunodeficiency syndrome (AIDS). This report describes the occurrence of a maxillary NHL as
Role of intralesional vinblastine administration in treatment of intraoral Kaposi's sarcoma in AIDS.: Eur J Cancer B Oral Oncol. 1995 Jul;31B(4):280-5. Unique Identifier : AIDSLINE MED/96103639; Flaitz CM; Nichols CM; Hicks MJ; Department of Stomatology, University of Texas-Houston Health; Science Center, USA.; The purpose of this clinical study was to determine the effect of intralesional vinblastine administration on intraoral Kaposi s sarcoma (KS) in AIDS patients. One hundred and forty-four KS lesions in 50 HIV-positive homosexual males (mean CD4 count 64/mm3) were treated periodically with intralesional vinblastine inje
Human immunodeficiency virus-related microvasculopathy and Kaposi's sarcoma: a case-control study.: Ger J Ophthalmol. 1995 Jul;4(4):239-45. Unique Identifier : AIDSLINE MED/96115075; Baumann S; Geier SA; Thoma-Gerber E; Noehl MA; Klauss V; Goebel FD; University Eye Hospital Munich, Germany.; Ocular microangiopathic syndrome including retinal and conjunctival abnormalities is frequently found in patients with human immunodeficiency virus type 1 (HIV-1) disease. Kaposi s sarcoma (KS) is the most frequent neoplasia found in patients with HIV-1 disease. We have recently reported a significant association betw
HIV/AIDS--no room for complacency [interview]: Aust Nurs J. 1995 Nov;3(5):8. Unique Identifier : AIDSLINE MED/96088189; Lawrence C
[Kaposi's sarcoma with ocular location in Zaire]: Bull Soc Belge Ophtalmol. 1994;254:117-21. Unique Identifier : AIDSLINE MED/96059824; Kaimbo Wa Kaimbo K; Service d'Ophtralmologie, Cliniques Universitaires de Kinshasa,; Zaire.; OBJECTIVE: a clinical study of patients with ocular adnexal Kaposi s sarcoma was undertaken to study its clinical characteristics. METHODS: A review of all patients with biopsy confirmed ocular adnexal Kaposi s sarcoma seen between 1962 and 1991. RESULTS: There were eleven patients during this period with the incidenc
Cost effectiveness and AIDS: science or marketing? Proceedings of a workshop. Washington, D.C., January 28, 1995.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;10 Suppl 4:S1-32. Unique Identifier : AIDSLINE MED/96115223
Evaluating the cost-effectiveness of pharmacologic therapy: where we've been and where we're going.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;10 Suppl 4:S1-5. Unique Identifier : AIDSLINE MED/96075582; Epstein AM; Department of Medicine, Brigham and Women's Hospital, Boston,; Massachusetts, USA.
Cost-effectiveness: from whose perspective?: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;10 Suppl 4:S14-8. Unique Identifier : AIDSLINE MED/96075584; Hillman AL; School of Medicine, University of Pennsylvania, Philadelphia,; USA.; Evaluating the cost-effectiveness of medical interventions, particularly pharmaceuticals, has been the focus of much debate in this country over the past few years. Although the support for efficient utilization of monies is widespread, the delicate balance between optimizing patient outcome with the costs to do so in
Working toward a common currency: is standardization of cost-effectiveness analysis possible?: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;10 Suppl 4:S19-22. Unique Identifier : AIDSLINE MED/96075585; Luce BR; MEDTAP International, Inc., Arlington, Virginia 22201, USA.; The field of cost-effectiveness has been quietly evolving for several decades. However, concerns and controversies have recently surfaced regarding the lack of standardization with which cost-effectiveness analyses are performed. This attention is due to the increasing use of the technique in rationing health care, se
Specific considerations for cost-effectiveness studies in AIDS.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;10 Suppl 4:S23-7. Unique Identifier : AIDSLINE MED/96075586; Bozzette SA; Medical Service, San Diego Veteran's Affairs Medical Center, CA; 92161, USA.; HIV disease is an epidemic with unique features that make it a challenging topic for pharmacoeconomic analysis. Unlike many other illnesses, the lengthy course of HIV disease, its relatively high incidence among young and productive individuals, and management of drug toxicities have an enormous impact on total costs.
Design and assessment of cost-effectiveness studies in AIDS populations.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;10 Suppl 4:S28-32. Unique Identifier : AIDSLINE MED/96075587; Simpson KN; Department of Health Policy and Administration, School of Public; Health, University of North Carolina at Chapel Hill 27599-7400,; USA.; Cost-effectiveness (CE) ratios are indicators of comparative efficiency of competing drugs. Unfortunately, they are subject to variations, depending on factors such as the study population chosen, the comparison treatment selected, and the economic analysis methods employed. CE ratios tend to be unfavorably skewed in
Understanding the essentials of economic evaluation.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;10 Suppl 4:S6-13. Unique Identifier : AIDSLINE MED/96075583; Schmid GP; Program Evaluation and Prevention Health Services Research; Branch, Centers for Disease Control and Prevention, Atlanta,; Georgia 30333, USA.; Economic evaluation (EE) answers the following simple question: From which course of action do we get the most value for our money? We ask this question because resources are always limited, i.e., we never have enough money to do all the things we would like to do. Three types of economic evaluations are used: cost-ef
Methods of transmission of hepatitis C.: J Viral Hepat. 1995;2(3):113-9. Unique Identifier : AIDSLINE MED/96091318; Tibbs CJ; Institute of Liver Studies, Kings College Hospital, London, UK.; The route of transmission of hepatitis C virus is still controversial. Parenteral exposure via blood or blood products leads to infection in the majority of cases, and the majority of intravenous drug users become infected by repetitive exposure to contaminated injection equipment. The risk of infection from a single
Nurses campaign for adolescent health and prevention of HIV infections.: Colo Nurse. 1995 Mar;95(1):16-7. Unique Identifier : AIDSLINE MED/96077888; Igoe JB
[Anatomo-clinical aspects of ganglionic tuberculosis in Senegal: comparative study between the 60's and 80-90's apropos of 139 cases]: Dakar Med. 1994;39(1):31-5. Unique Identifier : AIDSLINE MED/96092174; Woto-Gaye G; Boissy L; Mendes V; Boye IA; Boucal JC; Ndiaye PD; Service d'Anatomie et de Cytologie Pathologiques-Faculte de; Medecine et de Pharmacie de Dakar.; The authors report the results of a retrospective and comparative study of anatomo-clinical aspects of ganglionic tuberculosis carried out over two periods of five years each: first period: 1962-1966; second period: 1988-1992. This study shows a higher prevalence of this disease among children during the first period
[HIV infection: a new concern in dental public health]: Dakar Med. 1994;39(1):47-50. Unique Identifier : AIDSLINE MED/96092177; Faty Ndiaye C; Diallo B; Dia Tine S; Larroque G; Mboup S; Coll Seck AM; Institut d'Odonto-Stomatologie, Universite de Dakar.; The authors report the results of a seroepidemiological study, conducted in Senegal on dental personnel. This study allows them to confirm that professional dental practice is a factor of risk for the HIV infection. This study recommends work methods to the dental profession.
Characterization of the metabolites of the peptidomimetic human immunodeficiency virus type 1 protease inhibitor SK&F 107461 in rats using liquid chromatography/mass spectrometry.: Drug Metab Dispos. 1995 Aug;23(8):799-805. Unique Identifier : AIDSLINE MED/96020207; Potts W; van Horn R; Anderson K; Blake T; Garver E; Joseph G; Dreyer G; Shu A; Heys R; Fong KL; Department of Drug Metabolism and Pharmacokinetics, SmithKline; Beecham Pharmaceuticals, King of Prussia, PA 19406, USA.; The metabolic fate of SK&F 107461 [Cbz-Ala-Ala-Phe psi [CHOHCH2] Gly-Val-Val-OMe], a potent and specific inhibitor of the protease encoded by human immunodeficiency virus type 1, in male Sprague-Dawley rats is described. SK&F 107461 is a hexapeptide analog containing a hydroxyethylene linkage in place of one of
[Differential diagnosis of mononucleosis (letter)]: Dtsch Med Wochenschr. 1995 Dec 1;120(48):1680. Unique Identifier : AIDSLINE MED/96105192; Neifer S; Lass-Braun G
[Long-term survival with HIV infection. Virological-immunological studies of pathogenesis]: Dtsch Med Wochenschr. 1995 Dec 1;120(48):1682-3. Unique Identifier : AIDSLINE MED/96105194; L'age M; Auguste-Viktoria-Krankenhaus, Berlin.
Antibodies anti HTLV-I/II in Sicilian residents, in drug addicts, and in African immigrants [letter]: Eur J Epidemiol. 1995 Jun;11(3):359-60. Unique Identifier : AIDSLINE MED/96022518; Mansueto S; Miceli MD; Di Blasi P; Alleto G; Amico A; Mancuso S; Gentile G
Multiple myeloma associated with Epstein-Barr virus in an AIDS patient: a case report [letter]: Eur J Haematol. 1995 Nov;55(5):332-4. Unique Identifier : AIDSLINE MED/96096769; Ventura G; Lucia MB; Damiano F; Cauda R; Larocca LM
The management of pregnancy and delivery in HIV-infected women in Europe.: Eur J Obstet Gynecol Reprod Biol. 1995 Sep;62(1):7-13. Unique Identifier : AIDSLINE MED/96100098; Scaravelli G; Thorne C; Newell ML; Department of Paediatric Epidemiology, Institute of Child Health,; London, UK.; In view of the increasing heterosexual spread of HIV and reports of interventions which reduce the rate of mother to child transmission, a postal questionnaire survey was performed to determine the strategies for the management of pregnancy and delivery in HIV-infected women in 56 obstetric centres in 21 European coun
Fas-mediated cytotoxicity--a new immunoregulatory and pathogenic function of Th1 CD4+ T cells.: Immunol Rev. 1995 Aug;146:223-39. Unique Identifier : AIDSLINE MED/96037190; Yagita H; Hanabuchi S; Asano Y; Tamura T; Nariuchi H; Okumura K; Department of Immunology, Juntendo University School of Medicine,; Tokyo, Japan.
Mutational analysis of the substrate binding pocket of murine leukemia virus protease and comparison with human immunodeficiency virus proteases.: J Biol Chem. 1995 Dec 8;270(49):29162-8. Unique Identifier : AIDSLINE MED/96094303; Menendez-Arias L; Weber IT; Oroszlan S; Centro de Biologia Molecular Severo Ochoa, Consejo Superior de; Investigaciones Cientificas-Universidad Autonoma de Madrid,; Spain.; The differences in substrate specificity between Moloney murine leukemia virus protease (MuLV PR) and human immunodeficiency virus (HIV) PR were investigated by site-directed mutagenesis. Various amino acids, which are predicted to form the substrate binding site of MuLV PR, were replaced by the equivalent ones in HIV
Detection of microsporidia (Enterocytozoon bieneusi) in intestinal biopsy specimens from human immunodeficiency virus-infected patients by PCR.: J Clin Microbiol. 1995 Sep;33(9):2294-6. Unique Identifier : AIDSLINE MED/96025140; Franzen C; Muller A; Hegener P; Salzberger B; Hartmann P; Fatkenheuer G; Diehl V; Schrappe M; Department of Internal Medicine I, University of Cologne,; Germany.; Intestinal microsporidiosis has been implicated as a major cause of chronic diarrhea in human immunodeficiency virus (HIV)-infected patients. So far diagnosis depends on direct visualization of the parasites by light and transmission electron microscopy. We evaluated t
Detection of human immunodeficiency virus (HIV) type 1 antibodies by new automated microparticle enzyme immunoassay for HIV types 1 and 2.: J Clin Microbiol. 1995 Sep;33(9):2338-41. Unique Identifier : AIDSLINE MED/96025147; Matter L; Germann D; Institute for Medical Microbiology, University of Bern,; Switzerland.; We compared an automated microparticle double-antigen sandwich enzyme immunoassay (EIA) for the IMx test system recently developed by Abbott with two established assays (the automated indirect Vidas IgG EIA and the double-antigen sandwich EIA from Murex/Wellcome) devised for the detection of human immunodeficiency vir
Detection of Toxoplasma gondii by PCR and tissue culture in cerebrospinal fluid and blood of human immunodeficiency virus-seropositive patients.: J Clin Microbiol. 1995 Sep;33(9):2421-6. Unique Identifier : AIDSLINE MED/96025163; Dupon M; Cazenave J; Pellegrin JL; Ragnaud JM; Cheyrou A; Fischer I; Leng B; Lacut JY; Service de Medecine Interne, Hopital Pellegrin, Bordeaux,; France.; To investigate whether both tissue culture and PCR on a sequence from the repetitive rDNA could contribute to the diagnosis of toxoplasmosis, blood samples and, if they were available, cerebrospinal fluid (CSF) and aqueous humor samples from 72 human immunodeficiency virus-seropositive patients with suspected toxoplas
Prior enrichment of human immunodeficiency virus DNA with probe DNA particles for efficient PCR diagnosis.: J Clin Microbiol. 1995 Sep;33(9):2489-91. Unique Identifier : AIDSLINE MED/96025179; Tano H; Fan K; Kitajima MA; Kasai K; Tamatsukuri S; Furuichi Y; Hayashi T; Kondo M; Imai M; Tsukuba Research Laboratory, Japan Synthetic Rubber Co., Ltd.,; Japan.; We report here a novel method by which one can recover human immunodeficiency virus (HIV) DNA in a small volume (approximately 50 microliters) of solution from 8 ml of crude cell lysate which contains as few as several HIV DNA copies. The method uses the specific binding of HIV DNA to HIV probe DNA particles. The HIV
Species-specific Mycobacterium genavense DNA in intestinal tissues of individuals not infected with human immunodeficiency virus.: J Clin Microbiol. 1995 Sep;33(9):2514-5. Unique Identifier : AIDSLINE MED/96025187; Dumonceau JM; Fonteyne PA; Realini L; Van Gossum A; Van Vooren JP; Portaels F; Department of Gastroenterology, Hopital Erasme, Universite; Libre de Bruxelles, Belgium.; Mycobacterium genavense species-specific DNA was detected in intestinal tissues from two of nine individuals not infected with human immunodeficiency virus. This newly described microorganism is well documented as a causative agent of disseminated infections in AIDS patients. Our results suggest that it may colonize t
Anti-AIDS agents, 21. Triterpenoid saponins as anti-HIV principles from fruits of Gleditsia japonica and Gymnocladus chinensis, and a structure-activity correlation.: J Nat Prod. 1995 Sep;58(9):1372-7. Unique Identifier : AIDSLINE MED/96043281; Konoshima T; Yasuda I; Kashiwada Y; Cosentino LM; Lee KH; Kyoto Pharmaceutical University, Japan.; Gleditsia saponin C [1] and gymnocladus saponin G [2] were isolated from Gleditsia japonica and Gymnocladus chinensis, respectively, as anti-HIV principles. Compounds 1 and 2 demonstrated inhibitory effects against HIV replication in H-9 cells with EC50 values of 1.1 and 2.7 microM, respectively. Evaluation of the ant
Immunohistochemical study of linear gingival erythema from HIV-positive patients.: J Periodontal Res. 1995 Sep;30(5):355-9. Unique Identifier : AIDSLINE MED/96098579; Gomez RS; da Costa JE; Loyola AM; de Araujo NS; de Araujo VC; Departamento de Clinica, Patologia e Cirurgia da Faculdade de; Odontologia da Universidade Federal de Minas Gerais, Belo; Horizonte, Brasil.; Severe forms of periodontal disease are frequent in patients with acquired immunodeficiency syndrome (AIDS). Linear gingival erythema (LGE) is a progressive disease described in HIV-positive patients and is considered to be an early stage of necrotizing periodontitis. Although clinical and microbiological differences
Human immunodeficiency virus type 1 infection of SK-N-MC cells: domains of gp120 involved in entry into a CD4-negative, galactosyl ceramide/3' sulfo-galactosyl ceramide-positive cell line.: J Virol. 1995 Dec;69(12):7383-90. Unique Identifier : AIDSLINE MED/96078979; Harouse JM; Collman RG; Gonzalez-Scarano F; Department of Neurology, School of Medicine University of; Pennsylvania, Philadelphia 19104-6146, USA.; The primary receptor for human immunodeficiency virus (HIV) is the CD4 molecule; however, in vitro evidence suggests that a neutral glycolipid, galactosyl ceramide (GalCer) or a derivative molecule, 3 sulfogalactosyl ceramide (GalS), may serve as an alternative receptor for HIV type 1 (HIV-1) in cells of neural and c
High-titer packaging cells producing recombinant retroviruses resistant to human serum.: J Virol. 1995 Dec;69(12):7430-6. Unique Identifier : AIDSLINE GENBANK/X87829; Cosset FL; Takeuchi Y; Battini JL; Weiss RA; Collins MK; Chester Beatty Laboratory, Institute of Cancer Research, London,; United Kingdom.; Novel retroviral protein expression constructs were designed to retain minimal retroviral sequences and to express dominant selectable markers by reinitiation of translation after expression of the viral genes. HT1080 cells were selected as producer cells for their ability to release high-titer viruses that are resist
A Tat-induced auto-up-regulatory loop for superactivation of the human immunodeficiency virus type 1 promoter.: J Virol. 1995 Dec;69(12):7437-44. Unique Identifier : AIDSLINE MED/96078986; Biswas DK; Salas TR; Wang F; Ahlers CM; Dezube BJ; Pardee AB; Division of Cell Growth and Regulation, Dana-Farber Cancer; Institute, Boston, Massachusetts 02115, USA.; The virus-encoded Tat protein strongly activates transcription of human immunodeficiency virus (HIV). A well-recognized mechanism involves interaction of Tat with the nascent RNA transcript of the viral tar gene; mutation of tar greatly decreases activation by Tat. However, Tat still provides a low level of activation
Naturally occurring accessory gene mutations lead to persistent human immunodeficiency virus type 1 infection of CD4-positive T cells.: J Virol. 1995 Dec;69(12):7507-18. Unique Identifier : AIDSLINE MED/96078994; Kishi M; Zheng YH; Bahmani MK; Tokunaga K; Takahashi H; Kakinuma M; Lai PK; Nonoyama M; Luftig RB; Ikuta K; Section of Serology, Hokkaido University, Sapporo, Japan.; Proviral DNA from cells surviving severe but transient cytopathic effects, mediated by infection with recombinant human immunodeficiency virus type 1 (HIV-1) carrying a single gene mutation at vif, vpr, or vpu, was characterized by use of HIV-1-specific primer pairs in a two-step PCR. Deletion mutations were detected
Convergent evolution within the V3 loop domain of human immunodeficiency virus type 1 in association with disease progression.: J Virol. 1995 Dec;69(12):7548-58. Unique Identifier : AIDSLINE +; Strunnikova N; Ray SC; Livingston RA; Rubalcaba E; Viscidi RP; Department of Pediatrics, Johns Hopkins University School of; Medicine, Baltimore, Maryland 21287, USA.; Phylogenetic analysis was used to study in vivo genetic variation of the V3 region of human immunodeficiency virus type 1 in relation to disease progression in six infants with vertically acquired human immunodeficiency virus type 1 infection. Nucleotide sequences from each infant formed a monophyletic group with simi
High-resolution mapping of the human T-cell leukemia virus type 1 Rex-binding element by in vitro selection.: J Virol. 1995 Dec;69(12):7559-69. Unique Identifier : AIDSLINE MED/96078999; Baskerville S; Zapp M; Ellington AD; Department of Chemistry and Microbiology, Indiana University,; Bloomington 47405, USA.; Interactions be