T-cell recognition of mycobacterial antigens. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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T-cell recognition of mycobacterial antigens.

Eur Respir J Suppl. 1995 Sep;20:657s-667s. Unique Identifier : AIDSLINE MED/96163834
Vordermeier HM; MRC Tuberculosis & Related Infectious Unit, Clinical Sciences; Centre, Hammersmith Hospital, London, UK.

Abstract: T-cells play a dominant role in the immune response to mycobacterial infections. Most recognized mycobacterial antigens have been identified by monoclonal antibody techniques and, subsequently, sequenced and isolated by molecular cloning. Both CD4+ and CD8+ alpha beta T-cells, as well as gamma delta T-cells have been shown to participate in anti-mycobacterial host responses. The antigens recognized by CD4+ T-cells have been studied in most detail, with particular interest on proteins actively secreted by tubercle bacilli, on lipoproteins and on heat shock or stress proteins. Peptide mapping of T-cell epitopes of several mycobacterial proteins has suggested that many of their epitopes are recognized permissively in the context of multiple human and mouse major histocompatibility complex (MHC) class II alleles. This finding is encouraging for the development of subunit vaccines and diagnostic reagents.
Keywords: Animal Antigens, Bacterial/*IMMUNOLOGY CD4-CD8 Ratio Epitopes/IMMUNOLOGY Human Major Histocompatibility Complex/IMMUNOLOGY Mice Mycobacterium/*IMMUNOLOGY Mycobacterium tuberculosis/IMMUNOLOGY Mycobacterium, Atypical/IMMUNOLOGY T-Lymphocyte Subsets/*IMMUNOLOGY Vaccines, Synthetic/IMMUNOLOGY JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL

KWDanimalantigens,bacterial/KWDimmunologycd4-cd8ratioepitopes/immunologyhumanmajorhistocompatibilitycomplex/immunologymicemycobacterium/KWDimmunologymycobacteriumtuberculosis/immunologymycobacterium,atypical/immunologyt-lymphocytesubsets/KWDimmunologyvaccines,synthetic/immunologyjournalarticlereviewreview,tutorial
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Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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