Rapid plasma clearance and metabolism in vivo of a phosphorothioate oligodeoxynucleotide with a single, internal phosphodiester bond. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Rapid plasma clearance and metabolism in vivo of a phosphorothioate oligodeoxynucleotide with a single, internal phosphodiester bond.

Drug Metab Dispos. 1995 Nov;23(11):1297-300. Unique Identifier : AIDSLINE MED/96157469
Boado RJ; Kang YS; Wu D; Pardridge WM; Department of Medicine, UCLA School of Medicine 90024, USA.

Keywords: Animal Base Sequence Genes, tat HIV-1/ENZYMOLOGY In Vitro Male Molecular Sequence Data Oligodeoxyribonucleotides/*BLOOD/CHEMISTRY/PHARMACOKINETICS Rats Rats, Sprague-Dawley RNA, Messenger/BIOSYNTHESIS Sulfur Radioisotopes/DIAGNOSTIC USE Support, U.S. Gov't, P.H.S. Thionucleotides/*BLOOD/CHEMISTRY/PHARMACOKINETICS Tissue Distribution JOURNAL ARTICLE

KWDanimalbasesequencegenes,tathiv-1/enzymologyinvitromalemolecularsequencedataoligodeoxyribonucleotides/KWDblood/chemistry/pharmacokineticsratsrats,sprague-dawleyrna,messenger/biosynthesissulfurradioisotopes/diagnosticusesupport,uKWDsKWDgov't,pKWDhKWDsKWDthionucleotides/KWDblood/chemistry/pharmacokineticstissuedistributionjournalarticle
960630
M9660754

Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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