Phenotypic analysis of neoplastic cells from calf, thymic, and intermediate forms of bovine leukosis. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Phenotypic analysis of neoplastic cells from calf, thymic, and intermediate forms of bovine leukosis.

Vet Pathol. 1995 Nov;32(6):683-91. Unique Identifier : AIDSLINE MED/96162833
Asahina M; Kimura K; Murakami K; Ajito T; Wu D; Goryo M; Aida Y; Davis WC; Okada K; Department of Veterinary Pathology, Faculty of Agriculture, Iwate; University, Japan.

Abstract: Immunohistochemistry and flow cytometric analysis were used with monoclonal antibodies to examine the phenotype of neoplastic cells from cattle with sporadic bovine leukosis (three cases of calf form, two cases of thymic form, and three cases of intermediate form). Three cases of calf form and two cases of intermediate form were positive for B cell lineage in immunohistologic examination and in flow cytometric analysis for B-B2+, sIgM+, and major histocompatibility class II+. Two cases of thymic form and one case of intermediate form were CD2+, CD5+, CD6+, and CD8+ in immunohistologic examination and in flow cytometric analysis. The results show that neoplastic cells develop from B and T cell lineages in sporadic bovine leukosis.
Keywords: Animal Antigens, CD/ANALYSIS Antigens, CD2/ANALYSIS Antigens, CD5/ANALYSIS Antigens, CD8/ANALYSIS Antigens, Differentiation, T-Lymphocyte/ANALYSIS B-Lymphocytes/IMMUNOLOGY/*PATHOLOGY Base Sequence Cattle DNA Primers/CHEMISTRY Enzootic Bovine Leukosis/*CLASSIFICATION/*PATHOLOGY Female Flow Cytometry/VETERINARY Immunohistochemistry Kidney/IMMUNOLOGY/PATHOLOGY Liver/IMMUNOLOGY/PATHOLOGY Lymph Nodes/IMMUNOLOGY/PATHOLOGY Male Molecular Sequence Data Phenotype Pleura/IMMUNOLOGY/PATHOLOGY Polymerase Chain Reaction/VETERINARY Spleen/IMMUNOLOGY/PATHOLOGY Support, Non-U.S. Gov't T-Lymphocytes/IMMUNOLOGY/*PATHOLOGY Thymus Gland/IMMUNOLOGY/PATHOLOGY JOURNAL ARTICLE

KWDanimalantigens,cd/analysisantigens,cd2/analysisantigens,cd5/analysisantigens,cd8/analysisantigens,differentiation,t-lymphocyte/analysisb-lymphocytes/immunology/KWDpathologybasesequencecattlednaprimers/chemistryenzooticbovineleukosis/KWDclassification/
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M9660743

Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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