Demonstration of synergy with fluconazole and either ibuprofen, sodium salicylate, or propylparaben against Candida albicans in vitro. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Demonstration of synergy with fluconazole and either ibuprofen, sodium salicylate, or propylparaben against Candida albicans in vitro.

Antimicrob Agents Chemother. 1995 Dec;39(12):2610-4. Unique Identifier : AIDSLINE MED/96161267
Scott EM; Tariq VN; McCrory RM; School of Pharmacy, Queen's University of Belfast, Northern; Ireland, United Kingdom.

Abstract: The combination of fluconazole with either ibuprofen, sodium salicylate, or propylparaben resulted in synergistic activity (fractional inhibitory index, < 0.5) against Candida albicans NCYC 620 in a microdilution checkerboard assay. Synergism between miconazole and ibuprofen was also demonstrated. In three or four clinical isolates of C. albicans from AIDS patients, the combination of fluconazole and ibuprofen was synergistic. Preparation of the inoculum and the growth conditions used were those recommended by the National Committee for Clinical Laboratory Standards for susceptibility testing. A visual estimation of total inhibition of growth and determination of an 80% reduction in the optical density at 492 nm compared with those for the control were taken as endpoints for the calculation of synergy, and a good correlation between both estimates was demonstrated.
Keywords: Antifungal Agents/*PHARMACOLOGY AIDS-Related Opportunistic Infections/MICROBIOLOGY Candida albicans/*DRUG EFFECTS Candidiasis/MICROBIOLOGY Densitometry Drug Synergism Fluconazole/*PHARMACOLOGY Human Ibuprofen/*PHARMACOLOGY Microbial Sensitivity Tests Parabens/*PHARMACOLOGY Sodium Salicylate/*PHARMACOLOGY JOURNAL ARTICLE

KWDantifungalagents/KWDpharmacologyaids-relatedopportunisticinfections/microbiologycandidaalbicans/KWDdrugeffectscandidiasis/microbiologydensitometrydrugsynergismfluconazole/KWDpharmacologyhumanibuprofen/KWDpharmacologymicrobialsensitivitytestsparabens/KWDpharmacologysodiumsalicylate/KWDpharmacologyjournalarticle
960630
M9660738

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