Postantibiotic effect of clarithromycin alone and combined with ethambutol against Mycobacterium avium complex. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Postantibiotic effect of clarithromycin alone and combined with ethambutol against Mycobacterium avium complex.

Antimicrob Agents Chemother. 1995 Dec;39(12):2803-6. Unique Identifier : AIDSLINE MED/96161304
Ellis LC; Benson CA; Koenig GI; Trenholme GM; Department of Medicine, Rush Medical College,; Rush-Presbyterian-St Luke's Medical Center, Chicago, Illinois; 60612, USA.

Abstract: The postantibiotic effect (PAE) of clarithromycin alone and in combination with ethambutol was determined for two clinical blood isolates of Mycobacterium avium complex. An average PAE, ranging from 5.5 to 18.0 h, was noted for each isolate at each clarithromycin concentration except when isolate B was exposed to clarithromycin at the MIC. The addition of ethambutol did not enhance the PAE observed with clarithromycin alone. The clinical implications of the PAE of clarithromycin for M. avium complex remain to be determined.
Keywords: Antibiotics, Macrolide/*PHARMACOLOGY Antitubercular Agents/*PHARMACOLOGY AIDS-Related Opportunistic Infections/MICROBIOLOGY Clarithromycin/*PHARMACOLOGY Colony Count, Microbial Drug Interactions Ethambutol/*PHARMACOLOGY Human Mycobacterium avium Complex/*DRUG EFFECTS Mycobacterium avium-intracellulare Infection/MICROBIOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

KWDantibiotics,macrolide/KWDpharmacologyantitubercularagents/KWDpharmacologyaids-relatedopportunisticinfections/microbiologyclarithromycin/KWDpharmacologycolonycount,microbialdruginteractionsethambutol/KWDpharmacologyhumanmycobacteriumaviumcomplex/KWDdrugeffectsmycobacteriumavium-intracellulareinfection/microbiologysupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
960630
M9660731

Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1996. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1996. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .