Thalidomide inhibits lipoarabinomannan-induced upregulation of human immunodeficiency virus expression. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Thalidomide inhibits lipoarabinomannan-induced upregulation of human immunodeficiency virus expression.

Antimicrob Agents Chemother. 1995 Dec;39(12):2807-9. Unique Identifier : AIDSLINE MED/96161305
Peterson PK; Gekker G; Bornemann M; Chatterjee D; Chao CC; Department of Medicine, Hennepin County Medical Center,; Minneapolis, MN 55415, USA.

Abstract: Mycobacterium tuberculosis accelerates the progression of human immunodeficiency virus type 1 (HIV-1) infection. The results of this study, which show that thalidomide inhibits the upregulation of HIV-1 expression in U1 cells stimulated with mycobacterial lipoarabinomannans, support the rationale behind conducting controlled trials of this immunodeficiency agent with patients dually infected with HIV-1 and M. tuberculosis.
Keywords: Clone Cells Human HIV-1/*PHYSIOLOGY Lipopolysaccharides/*ANTAGONISTS & INHIB/CHEMISTRY/PHARMACOLOGY Mycobacterium tuberculosis/*CHEMISTRY Support, U.S. Gov't, P.H.S. Thalidomide/*PHARMACOLOGY Up-Regulation (Physiology)/DRUG EFFECTS Virus Replication JOURNAL ARTICLE

KWDclonecellshumanhiv-1/KWDphysiologylipopolysaccharides/KWDantagonists&inhib/chemistry/pharmacologymycobacteriumtuberculosis/KWDchemistrysupport,uKWDsKWDgov't,pKWDhKWDsKWDthalidomide/KWDpharmacologyup-regulation(physiology)/drugeffectsvirusreplicationjournalarticle
960630
M9660730

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