Immunomodulation by pycnogenol in retrovirus-infected or ethanol-fed mice. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Immunomodulation by pycnogenol in retrovirus-infected or ethanol-fed mice.

Life Sci. 1996;58(5):PL 87-96. Unique Identifier : AIDSLINE MED/96173233
Cheshier JE; Ardestani-Kaboudanian S; Liang B; Araghiniknam M; Chung S; Lane L; Castro A; Watson RR; Department of Family and Community Medicine, University of; Arizona, Tucson 85724, USA.

Abstract: Pycnogenol is a commercial mixture of bioflavonoids that exhibits antioxidative activity. The effects of dietary pycnogenol on immune dysfunction in normal mice as well as those fed ethanol or infected with the LP-BM5 murine retrovirus were determined. The ethanol consumption and retrovirus infection caused abnormalities in the function and/or structure of a broad array of cells involved in humoral and cellular immunity. Pycnogenol enhanced in vitro IL-2 production by mitogen-stimulated splenocytes if its production was suppressed in ethanol-fed or retrovirus-infected mice. Mitogenesis of splenocytes did not show a significant change in mice treated with pycnogenol. It reduced the elevated levels of interleukin-6 produced in vitro by cells from retrovirus infected mice and IL-10 secreted by spleen cells from mice consuming ethanol. Natural killer cell cytotoxicity was increased with pycnogenol treatment.
Keywords: Adjuvants, Immunologic/*PHARMACOLOGY Alcohol, Ethyl/*PHARMACOLOGY Alcoholism/IMMUNOLOGY Animal Antibody Formation/DRUG EFFECTS Bioflavonoids/*PHARMACOLOGY Cytokines/ANALYSIS/BIOSYNTHESIS Cytotoxicity, Immunologic/DRUG EFFECTS Enzyme-Linked Immunosorbent Assay Female Immunity, Cellular/DRUG EFFECTS Killer Cells, Natural/DRUG EFFECTS/IMMUNOLOGY Leukemia, Experimental Liver/METABOLISM Lymphocyte Transformation/DRUG EFFECTS Mice Mice, Inbred C57BL Murine Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Spleen/IMMUNOLOGY Support, Non-U.S. Gov't Vitamin E/METABOLISM JOURNAL ARTICLE

KWDadjuvants,immunologic/KWDpharmacologyalcohol,ethyl/KWDpharmacologyalcoholism/immunologyanimalantibodyformation/drugeffectsbioflavonoids/
960630
M9660698

Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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