1996

Tuberculosis today.: Eur Respir J Suppl. 1995 Sep;20:617s-619s. Unique Identifier : AIDSLINE MED/96163830; Chretien J
Epidemiology of tuberculosis in Europe.: Eur Respir J Suppl. 1995 Sep;20:620s-632s. Unique Identifier : AIDSLINE MED/96163831; Rieder HL; International Union Against Tuberculosis and Lung Disease, Paris,; France.; The risk of exposure to tuberculosis depends upon the incidence of infectious cases, the duration of their infectiousness, and the number of personal interactions an infectious case accomplishes per unit of time. The risk of infection, given exposure, depends on the density of infectious particles in the ambient air x
T-cell recognition of mycobacterial antigens.: Eur Respir J Suppl. 1995 Sep;20:657s-667s. Unique Identifier : AIDSLINE MED/96163834; Vordermeier HM; MRC Tuberculosis & Related Infectious Unit, Clinical Sciences; Centre, Hammersmith Hospital, London, UK.; T-cells play a dominant role in the immune response to mycobacterial infections. Most recognized mycobacterial antigens have been identified by monoclonal antibody techniques and, subsequently, sequenced and isolated by molecular cloning. Both CD4+ and CD8+ alpha beta T-cells, as well as gamma delta T-cells have been
Functions of T-cell subsets and cytokines in mycobacterial infections.: Eur Respir J Suppl. 1995 Sep;20:668s-675s. Unique Identifier : AIDSLINE MED/96163835; Munk ME; Emoto M; Dept of Immunology, University of Ulm, Germany.; Phagocytosed M. tuberculosis either multiply inside the endocytic compartment of mononuclear phagocytes or they are destroyed by the host cell. Due to this macrophage-shelter (ab)used by mycobacteria, tuberculosis is controlled by the cellular immune response. Protection against mycobacteria depends on alpha/beta T-ce
Serological diagnosis of tuberculosis.: Eur Respir J Suppl. 1995 Sep;20:676s-688s. Unique Identifier : AIDSLINE MED/96163836; Bothamley GH; Division of Thoracic Medicine, UCL Hospitals, Middlesex Hospital,; London, UK.; The past decade has seen dramatic developments in serological tests for tuberculosis. The long history of serological tests for tuberculosis is a testimony to the need for a sensitive diagnostic test, especially when the sputum smear is unhelpful. New reagents, both purified antigens and monoclonal antibodies, provide
Molecular diagnosis of tuberculosis.: Eur Respir J Suppl. 1995 Sep;20:689s-700s. Unique Identifier : AIDSLINE MED/96163837; Richeldi L; Barnini S; Saltini C; Dipartimento di Scienze Mediche, Oncologiche e Radiologiche,; Universita di Modena, Italy.; Rapid and sensitive tools for the diagnosis of tuberculosis are needed, due to the increased incidence of tuberculosis epidemics and the length of time required by classical diagnostic tests, especially among human immunodeficiency virus (HIV)-infected patients. In this context, the recent advances in cloning and char
Drug resistance in Mycobacterium tuberculosis.: Eur Respir J Suppl. 1995 Sep;20:701s-713s. Unique Identifier : AIDSLINE MED/96163838; Cole ST; Telenti A; Unite de Genetique Moleculaire Bacterienne, Institut; Pasteur, Paris, France.; During the last decade, there has been a marked increase in the number of gravity of tuberculosis cases both in developing countries and in industrialized nations. This is, in part, due to the acquired immune deficiency syndrome (AIDS) pandemic, but global economic depression, increased homelessness and declining cont
Alcohol consumption as a cofactor in the progression of HIV infection and AIDS.: Alcohol. 1995 Nov-Dec;12(6):547-52. Unique Identifier : AIDSLINE MED/96161341; Penkower L; Dew MA; Kingsley L; Zhou SY; Lyketsos CG; Wesch J; Senterfitt JW; Hoover DR; Becker JT; Department of Family Medicine and Clinical Epidemiology, School; of Medicine, University of Pittsburgh, PA 15260, USA.; Alcohol consumption as a cofactor in the progression of HIV infection was examined in 1,446 homosexual and bisexual HIV + men enrolled in the Multicenter AIDS Cohort Study who had a minimum of three visits. Two measures of drinking were employed: initial level, and pattern during the study period. Outcome measures inc
[Theoretical conformational NMR-analysis of RP342 peptide, affiliated with the immunogenic fragment of HIV-1 gp120 protein]: Dokl Akad Nauk. 1995 Oct;344(4):546-8. Unique Identifier : AIDSLINE MED/96097280; Andrianov AM
[Experimental use of a variant of the human immunodeficiency virus (HIV-1) with decreased sensitivity to 3'-azido-2',3'-dideoxythymidine and a study of its properties]: Dokl Akad Nauk. 1995 Oct;344(4):562-4. Unique Identifier : AIDSLINE MED/96097282; Selimova LM; Galegov GA
High-performance liquid chromatographic determination of a potent and selective HIV protease inhibitor (L-735,524) in rat, dog and monkey plasma.: J Chromatogr B Biomed Appl. 1995 Oct 6;672(1):111-7. Unique Identifier : AIDSLINE MED/96128899; Chen IW; Vastag KJ; Lin JH; Department of Drug Metabolism I, Merck Research Laboratories,; West Point, PA 19486, USA.; A high-performance liquid chromatographic method coupled with liquid-liquid sample extraction and ultraviolet detection has been developed for the quantification of L-735,524 (I), a potent, highly selective and orally bioavailable inhibitor of recombinant human immunodeficiency virus (HIV) protease in rat, dog and mon
High-performance liquid chromatographic determination of (-)-beta-D-2,6-diaminopurine dioxolane and its metabolite, dioxolane guanosine, using ultraviolet and on-line radiochemical detection.: J Chromatogr B Biomed Appl. 1995 Oct 6;672(1):119-24. Unique Identifier : AIDSLINE MED/96128900; Rajagopalan P; Gao Z; Chu CK; Schinazi RF; McClure HM; Boudinot FD; Department of Pharmaceutics, College of Pharmacy, University of; Georgia, Athens 30602-2353, USA.; (-)-beta-D-2,6-Diaminopurine dioxolane (DAPD) and its metabolite dioxolane guanosine (DXG) have potent activity against hepatitis B virus and HIV, in vitro. A reversed-phase HPLC analytical method using UV and on-line radiochemical detection for the determination of DAPD and DXG in monkey serum and urine is described
A comparison of nursing intervention classification and current procedural terminology codes for representing nursing interventions in HIV disease.: Medinfo. 1995;8 Pt 1:131-5. Unique Identifier : AIDSLINE MED/96174380; Henry SB; Holzemer WL; Reilly CA; Miller TJ; Randall C; School of Nursing, University of California, San Francisco,; California USA.; The purpose of this study was twofold: 1) to compare the ability of terms from the nursing intervention classification and from the current procedural terminology to represent the clinical terms used by nurses and patients to describe nursing interventions during hospitalization; and 2) to identify the strengths and w
The development of a controlled medical terminology: identification, collaboration, and customization.: Medinfo. 1995;8 Pt 1:148-52. Unique Identifier : AIDSLINE MED/96174384; Miller ET; Wieckert KE; Fagan LM; Musen MA; Section on Medical Informatics, Stanford University, Stanford, CA; 94305-5479 USA.; An increasing focus in health care is the development and use of electronic medical record systems to capture and store patient information. T-HELPER is an electronic medical record system that health care providers use to record ambulatory-care patient progress notes. These data are stored in an on-line database and
Representing HIV clinical terminology with SNOMED.: Medinfo. 1995;8 Pt 1:172. Unique Identifier : AIDSLINE MED/96174389; Cohen PT; Henry SB; University of California San Francisco AIDS Program at San; Francisco General Hospital.; 1. RESEARCH OBJECTIVES AND METHODS. Because of a need for a standard classification and coding system to encode data for HIV infected patients in the AIDS Program clinic at San Francisco General Hospital, we have begun a subset of clinical terms commonly used in the care of patients with HIV disease, and we have sough
Meeting information needs: analysis of clinicians' use of an HIV database through an electronic medical record.: Medinfo. 1995;8 Pt 1:323-6. Unique Identifier : AIDSLINE MED/96174425; Sands DZ; Libman H; Safran C; Center for Clinical Computing, Division of General Medicine and; Beth Israel Hospital, Harvard Medical School, 350 Longwood; Avenue, Boston, MA 02115 USA.; We developed an on-line medical record (OMR) and integrated it into a mature hospital information system. The OMR provides a number of information resources for the care of patients infected with the human immuno-deficiency virus (HIV), including drug information, an on-line version of a newsletter on AIDS, an on-line
A standards-based clinical information system for HIV/AIDS.: Medinfo. 1995;8 Pt 1:402. Unique Identifier : AIDSLINE MED/96174287; Stitt FW; Department of Epidemiology, University of Miami School of; Medicine, FL 33101, USA.; Objective: To create a clinical data repository to interface the Veteran s Administration (VA) Decentralized Hospital Computer Program (DHCP) and a departmental clinical information system for the management of HIV patients. This system supports record-keeping, decision-making, reporting, and analysis. The database de
PROTEGE-II: computer support for development of intelligent systems from libraries of components.: Medinfo. 1995;8 Pt 1:766-70. Unique Identifier : AIDSLINE MED/96174255; Musen MA; Gennari JH; Eriksson H; Tu SW; Puerta AR; Section on Medical Informatics, Stanford University School of; Medicine, Stanford, California 94305-5479, USA.; PROTEGE-II is a suite of tools that facilitates the development of intelligent systems. A tool called MAiTRE allows system builders to create and refine abstract models (ontologies) of application domains. A tool called DASH takes as input a modified domain ontology and generates automatically a knowledge-acquisition
Hierarchical neural networks for survival analysis.: Medinfo. 1995;8 Pt 1:828-32. Unique Identifier : AIDSLINE MED/96174270; Ohno-Machado L; Walker MG; Musen MA; Section on Medical Informatics, Stanford University School of; Medicine, MSOB X-215 Stanford CA 94305-5479, USA.; Neural networks offer the potential of providing more accurate predictions of survival time than do traditional methods. Their use in medical applications has, however, been limited, especially when some data is censored or the frequency of events is low. To reduce the effect of these problems, we have developed a hie
A clinical trial of a knowledge-based medical record.: Medinfo. 1995;8 Pt 2:1076-80. Unique Identifier : AIDSLINE MED/96174193; Safran C; Rind DM; Davis RB; Sands DZ; Caraballo E; Rippel K; Wang Q; Rury C; Makadon HJ; Cotton DJ; et al; Department of Medicine, Beth Israel Hospital, Center for Clinical; Computing, Harvard Medical School, Boston MA, USA.; To meet the needs of primary care physicians caring for patients with HIV infection, we developed a knowledge-based medical record to allow the on-line patient record to play an active role in the care process. These programs integrate the on-line patient record, rule-based decision support, and full-text information
Prevention of AIDS and living together with an HIV-infected patient.: Medinfo. 1995;8 Pt 2:1191. Unique Identifier : AIDSLINE MED/96174065; Fahik FT; Reichert MC; Gabriel R; Marin HF; Nursing Informatics Group, Escola Paulista de Medicina, Sao; Paulo, Brazil.; In Brazil , approximately 45 thousand cases had been reported until the end of 1993, with an estimated 50% underreport. According to the Ministry of Health, until the year 2,000 from 2 to 8 million Brazilians citizens will be infected with HIV. The basic aspect of the educational ca
Life time expectancy of hemophilia patients infected with HIV-1 with the risk of hepatocellular carcinoma after HCV infection.: Medinfo. 1995;8 Pt 2:912. Unique Identifier : AIDSLINE MED/96174148; Tatsunami S; Mimaya J; Nakamura I; Yago N; Meguro T; Yamada K; Radioisotope Research Institute, Department of Hygiene,; Department of Pediatrics and Institute of Medical Science, St.; Marianna University School of Medicine, Kawasaki, JAPAN 216.; 1. INTRODUCTION. The latest statistics how that Japanese hemophilia patients infected with HIV-through clotting factor concentrates may survive more than 10 years after HIV-infection without showing an onset of AIDS [1]. Unfortunately, however, results of the recent surveillance have revealed that about half of hemoph
An integrated system to represent and manage medical knowledge.: Medinfo. 1995;8 Pt 2:931-3. Unique Identifier : AIDSLINE MED/96174154; Fiore M; Sicurello F; Indorato G; National Research Council, Institute of Advanced Biomedical; Technologies, via Ampere 56, 20131, Milano.; This paper describes an integrated system in Prolog that permits the creation of a personal Knowledge Base to express and formalize specialist knowledge in medicine. Formalisms used are production rules and frames. The integrated system is able to manage data and knowledge stored in a database built in M Technology (M
HIV infection in London children--psychosocial complexity and emotional burden.: Child Care Health Dev. 1995 Nov;21(6):405-12. Unique Identifier : AIDSLINE MED/96153073; Melvin D; Sherr L; Department of Paediatrics, St Mary's Hospital, London, UK.
Rapid plasma clearance and metabolism in vivo of a phosphorothioate oligodeoxynucleotide with a single, internal phosphodiester bond.: Drug Metab Dispos. 1995 Nov;23(11):1297-300. Unique Identifier : AIDSLINE MED/96157469; Boado RJ; Kang YS; Wu D; Pardridge WM; Department of Medicine, UCLA School of Medicine 90024, USA.
[Findings in the eyes of serologically FIV (feline immunodeficiency virus) positive cats]: DTW Dtsch Tierarztl Wochenschr. 1995 Sep;102(9):348-51. Unique Identifier : AIDSLINE MED/96005269; Loesenbeck G; Drommer W; Heider HJ; Institut fur Pathologie, Tierarztliche Hochschule Hannover.; The findings in the eyes of 19 serologically FIV-positive cats in the terminal stage of the disease were compared to those in 23 serologically FIV-negative cats. An inflammation of iris and ciliary body was more common in the FIV-group than in the other cats and could be seen in 16 out of 19 serologically FIV-positive
Effect of interferon alfa on the dynamics of hepatitis C virus turnover in vivo.: Hepatology. 1996 Feb;23(2):366-71. Unique Identifier : AIDSLINE MED/96162064; Zeuzem S; Schmidt JM; Lee JH; Ruster B; Roth WK; Medizinische Klinik II, Klinikum der Johann Wolfgang; Goethe-Universitat, Frankfurt am Main, Germany.; In about 30% to 40% of patients with chronic hepatitis C, treatment with recombinant interferon alfa (r-IFN alpha) causes a decrease of serum aminotransferases and hepatitis C virus (HCV) RNA. The antiviral mechanism of interferon alfa (IFN alpha) in vivo is unknown. From serial measurements of serum HCV-RNA concentra
In-vitro activity of terbinafine, atovaquone and co-trimoxazole against Pneumocystis carinii [letter]: J Antimicrob Chemother. 1995 Oct;36(4):740-2. Unique Identifier : AIDSLINE MED/96159652; Cirioni O; Giacometti A; Balducci M; Burzacchini F; Scalise G
The management of mycobacterial infection--a UK survey [letter]: J Antimicrob Chemother. 1995 Oct;36(4):745-7. Unique Identifier : AIDSLINE MED/96159655; Lovering AM; White LO; Acaye C; Reeves DS; MacGowan AP
Elevated levels of the endogenous retrovirus ERV3 in human sebaceous glands.: J Invest Dermatol. 1996 Jan;106(1):125-8. Unique Identifier : AIDSLINE MED/96154069; Andersson AC; Merza M; Venables P; Ponten F; Sundstrom J; Cohen M; Larsson E; Department of Pathology, Uppsala University Hospital, Sweden.; ERV3 (HERV-R) is a complete human endogenous retrovirus located on the long arm of chromosome 7. Long terminal repeat-envelope (env) gene spliced mRNAs of 9 and 3.5 kb are widely expressed in human tissues and cells, but gag-pol mRNAs have not been found. Furthermore, the env gp70 gene contains an open reading frame t
Human immunodeficiency virus load. Quantitative assessment in semen from seropositive individuals and in spiked seminal plasma.: J Reprod Med. 1995 Nov;40(11):747-57. Unique Identifier : AIDSLINE MED/96147047; Rasheed S; Li Z; Xu D; Department of Pathology, University of Southern California School; of Medicine, Los Angeles 90032-3626, USA.; OBJECTIVE: To establish criteria for the quantitation of the human immunodeficiency virus (HIV) in seminal plasma, seminal cells and the whole semen of HIV-infected individuals. The reverse transcription polymerase chain reaction (RT-PCR), DNA-PCR and semen HIV culture assays were standardized by testing seminal plasm
Transient HIV infection in infants [letter]: N Engl J Med. 1996 Mar 21;334(12):801-2. Unique Identifier : AIDSLINE MED/96172884; McMichael A; Koup R; Ammann AJ
Solvent polarity-dependent structural refolding: a CD and NMR study of a 15 residue peptide.: Proteins. 1995 Oct;23(2):196-203. Unique Identifier : AIDSLINE MED/96131681; Graf von Stosch A; Jimenez MA; Kinzel V; Reed J; Department of Pathochemistry, German Cancer Research Center,; Heidelberg, Germany.; A close association between the HIV surface protein gp120 and the CD4 T cell receptor initiates the viral multiplication cycle. A 15 amino acid peptide (LAV) within the CD4 binding domain of gp 120 has been shown to retain receptor binding ability. The structural behavior of the LAV peptide has been studied by CD and
[New advancements in the study of infection (news)]: Pharm Unserer Zeit. 1995 Nov;24(6):339. Unique Identifier : AIDSLINE MED/96141546
Improving the quality of care for persons with HIV infection in sub-Saharan Africa.: Trop Geogr Med. 1995;47(2):78-81. Unique Identifier : AIDSLINE MED/96174536; Colebunders R; Decock R; Mbeba MJ; Department of Microbiology, Institute of Tropical Medicine,; Antwerp, Belgium.; Caring for persons with HIV infection is particularly difficult in resource-poor countries. In order to improve the quality of care we first have to evaluate how such care is presently organized. We need a better assessment of the needs and demands of persons with HIV infection as well as their families. Care for pers
Phenotypic analysis of neoplastic cells from calf, thymic, and intermediate forms of bovine leukosis.: Vet Pathol. 1995 Nov;32(6):683-91. Unique Identifier : AIDSLINE MED/96162833; Asahina M; Kimura K; Murakami K; Ajito T; Wu D; Goryo M; Aida Y; Davis WC; Okada K; Department of Veterinary Pathology, Faculty of Agriculture, Iwate; University, Japan.; Immunohistochemistry and flow cytometric analysis were used with monoclonal antibodies to examine the phenotype of neoplastic cells from cattle with sporadic bovine leukosis (three cases of calf form, two cases of thymic form, and three cases of intermediate form). Three cases of calf form and two cases of intermediat
Localized retroperitoneal fibromatosis causing intestinal obstruction in a cynomolgus monkey (Macaca fascicularis).: Vet Pathol. 1995 Nov;32(6):713-6. Unique Identifier : AIDSLINE MED/96162837; Fikes JD; O'Sullivan MG; Department of Comparative Medicine, Bowman Gray School of; Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1040,; USA.; Gross examination of a 24-month-old, male cynomolgus monkey (Macaca fascicularis) revealed obstruction of the ileum by a mass that entrapped and compressed the ileocecal junction. The mass was well circumscribed, firm, and white on cut surface. Histologically, the mass consisted of spindle-shaped cells arranged in int
Increase of antigen production in BLV-infected cell lines via additional expression of tax.: Zentralbl Veterinarmed [B]. 1995 Nov;42(9):543-50. Unique Identifier : AIDSLINE MED/96092126; Wagner HJ; Blankenstein P; Bondzio A; Ebner D; Risse S; Free University Berlin, Department of Veterinary Medicine,; Germany.; The selection of animals infected with the bovine leukaemia virus (BLV) is performed by the immunological detection of antibodies against the virus, commonly using the antigen gp51. Furthermore, research is being carried out to develop protective vaccines against BLV that have gp51 as their main component. Taking both
The non-drug treatment of asthma.: Acta Paediatr Sin. 1995 Nov-Dec;36(6):401-4. Unique Identifier : AIDSLINE MED/96165944; Liang AY; Pediatrician of Auckland Children's Hospital, New Zealand.; Anti-asthma medication alone cannot be considered a complete treatment for asthma. Drugs have not made an impact on asthma mortality, yet may cause significant side-effects. Minimising exposure to environmental allergens decreases the severity of asthma attacks and therefore decreases the amount of medication required
L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase.: Antimicrob Agents Chemother. 1995 Dec;39(12):2602-5. Unique Identifier : AIDSLINE MED/96161265; Young SD; Britcher SF; Tran LO; Payne LS; Lumma WC; Lyle TA; Huff JR; Anderson PS; Olsen DB; Carroll SS; et al; Department of Medicinal Chemistry, Merck Research Laboratories,; West Point, Pennsylvania 19486, USA.; The clinical benefit of the human immunodeficiency virus type 1 (HIV-1) nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) is limited by the rapid selection of inhibitor-resistant viral variants. However, it may be possible to enhance the clinical utility of this inhibitor class by deriving compounds that ex
Demonstration of synergy with fluconazole and either ibuprofen, sodium salicylate, or propylparaben against Candida albicans in vitro.: Antimicrob Agents Chemother. 1995 Dec;39(12):2610-4. Unique Identifier : AIDSLINE MED/96161267; Scott EM; Tariq VN; McCrory RM; School of Pharmacy, Queen's University of Belfast, Northern; Ireland, United Kingdom.; The combination of fluconazole with either ibuprofen, sodium salicylate, or propylparaben resulted in synergistic activity (fractional inhibitory index,
Genetic basis of macrolide resistance in Mycobacterium avium isolated from patients with disseminated disease.: Antimicrob Agents Chemother. 1995 Dec;39(12):2625-30. Unique Identifier : AIDSLINE GENBANK/X74494; Nash KA; Inderlied CB; Department of Pathology and Laboratory Medicine, Children's; Hospital Los Angeles, CA 90027, USA. kanash@hsc.usc.edu; Clarithromycin (CLM) and azithromycin (AZM) are important agents in the treatment of disseminated Mycobacterium avium complex disease; however, monotherapy with these macrolides often leads to clinically significant resistance. The underlying resistance mechanism was investigated by comparing 23S rRNA gene sequences i
Monitoring of co-trimoxazole concentrations in serum during treatment of pneumocystis carinii pneumonia.: Antimicrob Agents Chemother. 1995 Dec;39(12):2661-6. Unique Identifier : AIDSLINE MED/96161277; Joos B; Blaser J; Opravil M; Chave JP; Luthy R; Division of Infectious Diseases, University Hospital, Zurich,; Switzerland.; The purpose of this prospective randomized open trial was to investigate the impact of monitoring concentrations in serum on the efficacy and side effects of high-dose co-trimoxazole therapy. Forty consecutive patients with microscopically confirmed Pneumocystis carinii pneumonia were enrolled. Therapy was started wit
Structure-activity and cross-resistance evaluations of a series of human immunodeficiency virus type-1-specific compounds related to oxathiin carboxanilide.: Antimicrob Agents Chemother. 1995 Dec;39(12):2718-27. Unique Identifier : AIDSLINE MED/96161287; Buckheit RW Jr; Kinjerski TL; Fliakas-Boltz V; Russell JD; Stup TL; Pallansch LA; Brouwer WG; Dao DC; Harrison WA; Schultz RJ; et al; Virology Research Group, Southern Research Institute-Frederick; Research Center, Maryland 21701, USA.; A series of compounds related to the nonnucleoside reverse transcriptase (RT) inhibitor (NNRTI) oxathiin carboxanilide (UC84) were evaluated for activity against the human immunodeficiency virus (HIV) to determine structural requirements for anti-HIV activity. Twenty-seven compounds representative of the more than 400
Pharmacokinetics and bioavailability of zidovudine and its glucuronidated metabolite in patients with human immunodeficiency virus infection and hepatic disease (AIDS Clinical Trials Group protocol 062).: Antimicrob Agents Chemother. 1995 Dec;39(12):2732-7. Unique Identifier : AIDSLINE MED/96161289; Moore KH; Raasch RH; Brouwer KL; Opheim K; Cheeseman SH; Eyster E; Lemon SM; van der Horst CM; University of North Carolina, Chapel Hill 27599-7360, USA.; The pharmacokinetics of zidovudine (ZDV) are established in patients with various stages of human immunodeficiency virus (HIV) disease. This study was conducted to determine the pharmacokinetic parameters of ZDV in patients with asymptomatic HIV infection and liver disease. HIV-infected volunteers with normal renal fu
Pharmacokinetics of lamivudine and BCH-189 in plasma and cerebrospinal fluid of nonhuman primates.: Antimicrob Agents Chemother. 1995 Dec;39(12):2779-82. Unique Identifier : AIDSLINE MED/96161298; Blaney SM; Daniel MJ; Harker AJ; Godwin K; Balis FM; Pediatric Branch, National Cancer Institute, Bethesda, Maryland; 20892, USA.; 2 -Deoxy-3 -thiacytidine is a dideoxycytidine analog with a sulfur in place of the 3 carbon of the ribose. There are two enantiomeric forms of the compound, both of which inhibit human immunodeficiency virus type 1 and 2 replication in vitro. However, the (-) enantiomer (lamivudine) appears to be significantly less c
Strategies for control of zidovudine concentrations in serum.: Antimicrob Agents Chemother. 1995 Dec;39(12):2792-7. Unique Identifier : AIDSLINE MED/96161301; Noormohamed SE; Henry WK; Rhame FS; Balfour HH Jr; Fletcher CV; Department of Pharmacy Practice, University of Minnesota Health; Sciences Center, Minneapolis 55455, USA.; There are several clinical scenarios in which knowledge of zidovudine disposition may be important. This study evaluated the clinical utility of pharmacokinetic parameters for zidovudine derived from sparse serum concentration data obtained in an outpatient setting. Twelve human immunodeficiency virus-infected partici
Postantibiotic effect of clarithromycin alone and combined with ethambutol against Mycobacterium avium complex.: Antimicrob Agents Chemother. 1995 Dec;39(12):2803-6. Unique Identifier : AIDSLINE MED/96161304; Ellis LC; Benson CA; Koenig GI; Trenholme GM; Department of Medicine, Rush Medical College,; Rush-Presbyterian-St Luke's Medical Center, Chicago, Illinois; 60612, USA.; The postantibiotic effect (PAE) of clarithromycin alone and in combination with ethambutol was determined for two clinical blood isolates of Mycobacterium avium complex. An average PAE, ranging from 5.5 to 18.0 h, was noted for each isolate at each clarithromycin concentration except when isolate B was exposed to clar
Thalidomide inhibits lipoarabinomannan-induced upregulation of human immunodeficiency virus expression.: Antimicrob Agents Chemother. 1995 Dec;39(12):2807-9. Unique Identifier : AIDSLINE MED/96161305; Peterson PK; Gekker G; Bornemann M; Chatterjee D; Chao CC; Department of Medicine, Hennepin County Medical Center,; Minneapolis, MN 55415, USA.; Mycobacterium tuberculosis accelerates the progression of human immunodeficiency virus type 1 (HIV-1) infection. The results of this study, which show that thalidomide inhibits the upregulation of HIV-1 expression in U1 cells stimulated with mycobacterial lipoarabinomannans, support the rationale behind conducting con
Knocking out human immunodeficiency virus through non-nucleoside reverse transcriptase inhibitors used as single agents or in combinations: a paradigm for the cure of AIDS?: Farmaco. 1995 Nov;50(11):735-47. Unique Identifier : AIDSLINE MED/96153903; De Clercq E; Balzarini J; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.; A large variety of compounds have been reported to inhibit the replication of human immunodeficiency virus (HIV). The compounds that have been most intensively pursued for the treatment of HIV infection belong to three classes: nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase i
2-(4-Pyridyl)-delta 2-1,3,4-oxadiazolines from isonicotinoylhydrazones and diazomethane as potential antimycobacterial and anti-HIV agents. V.: Farmaco. 1995 Nov;50(11):783-6. Unique Identifier : AIDSLINE MED/96153906; Vigorita MG; Ottana R; Zappala C; Maccari R; Pizzimenti FC; Gabbrielli G; Dipartimenti Farmaco-chimico, Universita di Messina, Italy.; The 5-aryl-4-methyl-2-(4-pyridyl)-delta 2-1,3,4-oxadiazolines 3, previously synthesized along with isomer 4-aryl-1-methoxy-1-(4-pyridyl)-2,3-diaza-1,3-butadienes 2 from benzaldehyde isonicotinoylhydrazones and diazomethane, were tested for in vitro activity against both M. tuberculosis and some atypical mycobacterial
Preparation and characterization of conjugates of (modified) human serum albumin and liposomes: drug carriers with an intrinsic anti-HIV activity.: Biochim Biophys Acta. 1996 Jan 31;1278(2):183-90. Unique Identifier : AIDSLINE MED/96174859; Kamps JA; Swart PJ; Morselt HW; Pauwels R; De Bethune MP; De Clercq E; Meijer DK; Scherphof GL; Groningen Institute for Drug Studies, Department of Physiological; Chemistry, Groningen University, Groningen, The Netherlands.; Human serum albumin (HSA) derivatized with cis-aconitic anhydride (Aco-HSA) that was earlier shown to inhibit replication of human immunodeficiency virus type 1 (HIV-1), was covalently coupled to conventional liposomes, consisting of phosphatidylcholine, cholesterol and maleimido-4-(p-phenylbutyryl)phosphatidylethanol
Molecular interactions between retroviruses and herpesviruses.: J Vet Med Sci. 1995 Oct;57(5):8O1-11. Unique Identifier : AIDSLINE MED/96155841; Kawaguchi Y; Mikami T; Department of Veterinary Microbiology, Faculty of Agriculture,; University of Tokyo, Japan.; Human and animal herpesviruses are able to stimulate gene expression of various human and animal retroviruses and the activation appears to be a common theme. It is of interest why the retroviruses can be commonly activated by herpesviruses despite clear diversities in each mechanism for retrovirus gene expression. In
Turkey rhinotracheitis virus isolated from broiler chicken with swollen head syndrome in Japan.: J Vet Med Sci. 1995 Oct;57(5):939-41. Unique Identifier : AIDSLINE MED/96155864; Tanaka M; Takuma H; Kokumai N; Oishi E; Obi T; Hiramatsu K; Shimizu Y; Division of Veterinary Microbiology, Kyoto Biken Laboratories,; Japan.; Turkey rhinotracheitis (TRT) virus was first isolated from a commercial broiler chicken with swollen head syndrome (SHS) in Japan . At the same time, Newcastle disease virus (NDV), infectious bronchitis virus (IBV), avian reovirus (ARV), Escherich
The typically 'atypical' radiographic presentation of tuberculosis in advanced HIV disease [editorial]: Tuber Lung Dis. 1995 Dec;76(6):475-6. Unique Identifier : AIDSLINE MED/96167152; Daley CL
[The new face of tuberculosis in the context of the tuberculosis-HIV association in Abidjan, Ivory Coast]: Tuber Lung Dis. 1995 Dec;76(6):505-9. Unique Identifier : AIDSLINE MED/96167157; Domoua K; Coulibaly G; N'Dhatz M; Traore F; Kanga K; Konan JB; Beugre LK; Yapi A; Service de pneumophtisiologie, CHU de Treichville, Abidjan, Cote; d'Ivoire.; This article reviews the main clinical aspects and progression of HIV-related tuberculosis in Abidjan. HIV prevalence in tuberculosis patients is high, estimated at 46.2% in 1992, with a clear predominance of HIV-1 over HIV-2. More than 61% of co-infected tuberculous patients meet the WHO s clinical definition of AIDS
Predictive markers of survival in HIV-seropositive and HIV-seronegative Tanzanian patients with extrapulmonary tuberculosis.: Tuber Lung Dis. 1995 Dec;76(6):510-7. Unique Identifier : AIDSLINE MED/96167158; Richter C; Koelemay MJ; Swai AB; Perenboom R; Mwakyusa DH; Oosting J; Department of Medicine, Muhimbili Medical Centre, Dar es Salaam,; Tanzania.; SETTING: Prediction of survival in Tanzanian patients with extrapulmonary tuberculosis (TB). OBJECTIVE: To evaluate the prognostic value of clinical and laboratory parameters on survival in human immunodeficiency virus (HIV) seropositive and HIV seronegative patients with extrapulmonary TB. DESIGN: Over an 8-month per
Pulmonary tuberculosis in HIV infection: radiographic appearance is related to CD4+ T-lymphocyte count.: Tuber Lung Dis. 1995 Dec;76(6):518-21. Unique Identifier : AIDSLINE MED/96167159; Post FA; Wood R; Pillay GP; Department of Medicine, UCT Medical School, Cape Town, South; Africa.; SETTING: An adult HIV outpatient clinic in Cape Town, South Africa . OBJECTIVE: To investigate the relationship between the radiographic appearance of pulmonary tuberculosis (PTB) in HIV infected patients and CD4+ T-lymphocyte count. DESIGN: Pretreatment radiographs of 150 patients
Epidemiological trends of tuberculosis in Spain from 1988 to 1992. Collaborative Group for the Study of Tuberculosis in Spain.: Tuber Lung Dis. 1995 Dec;76(6):522-8. Unique Identifier : AIDSLINE MED/96167160; SETTING: Spain is one of the few industrialized countries in which reliable official data on the occurrence of tuberculosis are not available. OBJECTIVE: One of the purposes of the Tuberculosis and Respiratory Infection (TRI) working group established by the Spanish Society of Thora
Epidemiology of Mycobacterium bovis infection in animals and humans, with particular reference to Africa.: Rev Sci Tech. 1995 Sep;14(3):733-46. Unique Identifier : AIDSLINE MED/96014322; Cosivi O; Meslin FX; Daborn CJ; Grange JM; Division of Communicable Diseases, World Health Organisation,; Geneva, Switzerland.; The epidemiology of Mycobacterium bovis infection in animals and humans is described, together with a review of available reports on the distribution and prevalence of this mycobacteriosis in Africa. The significance of these reports is considered, with particular emphasis on the potential zoonotic importance of bovin
Percutaneous penetration of fluorescein isothiocyanate-dextrans and the mechanism for enhancement effect of enhancers on the intercellular penetration.: Biol Pharm Bull. 1995 Nov;18(11):1566-71. Unique Identifier : AIDSLINE MED/96161468; Ogiso T; Paku T; Iwaki M; Tanino T; Faculty of Pharmaceutical Sciences, Kinki University, Osaka,; Japan.; To identify the mechanism involved in the enhancement effect of enhancers on the intercellular penetration of large polar molecules, the skin penetration of fluorescein isothiocyanate (FITC)-dextrans (average molecular weight; 4400, 9400, and 69000 Da) and the lipid removal from the intercellular spaces by enhancers w
Testing tissue donors [editorial]: Transfus Med. 1995 Sep;5(3):167-70. Unique Identifier : AIDSLINE MED/96056730; Lumley SP; McClelland DB
Screening for cytomegalovirus retinitis in HIV-positive and AIDS patients.: QJM. 1995 Dec;88(12):899-903. Unique Identifier : AIDSLINE MED/96167124; Sandy CJ; Ferris JD; Bloom PA; Coker RJ; Pinching AJ; Migdal CS; Western Eye Hospital (St Mary's Hospital NHS Trust), London, UK.; The ability of physicians to screen for AIDS-related cytomegalovirus retinitis (CMVR) was studied at a London AIDS centre. Patients had undergone direct ophthalmoscopy as part of their general examination by the physicians and were referred if fundal abnormalities were found, if a
Classic Kaposi's sarcoma with pulmonary involvement in an HIV-negative woman.: Clin Exp Dermatol. 1995 Sep;20(5):410-2. Unique Identifier : AIDSLINE MED/96169716; Coll J; Pedro-Botet J; Pallas JO; Gimenez-Arnau AM; Barranco C; Department of Medicine, Hospital del Mar, Universidad Autonoma; de Barcelona, Spain.; Visceral involvement in HIV-negative patients with classical Kaposi s sarcoma (KS) has been described only rarely. An unusual case of a 75-year-old Jewish woman with the classical form of KS who presented with cutaneous and pulmonary involvement is presented. Results of several tests for HIV antibodies were negative.
Multiple pilomatricomas and myotonic dystrophy in a patient with AIDS.: Clin Exp Dermatol. 1995 Sep;20(5):423-4. Unique Identifier : AIDSLINE MED/96169720; Farrell AM; Ross JS; Barton SE; Bunker CB; Department of Dermatology, Chelsea and Westminister Hospital,; London, UK.; We report a 43-year-old man with myotonic dystrophy who developed multiple pilomatricomas 2 years after being diagnosed as having AIDS. This is the first report of pilomatricomas developing in an HIV-1 seropositive patient.
Handpiece and water line decontamination and HIV transmission: a critique.: Dent Update. 1993 Mar;20(2):53-4, 56. Unique Identifier : AIDSLINE MED/96175762; Samaranayake L; Oral Biology Unit, Faculty of Dentistry, The University of Hong; Kong.; The survival of infective viral particles in disinfected handpieces and the dental unit water systems has become a matter of professional and public concern. This commentary evaluates the evidence, making some practical suggestions on water line decontamination and handpiece sterilization.
Transfer of diabetes in the NOD-scid mouse by CD4 T-cell clones. Differential requirement for CD8 T-cells.: Diabetes. 1996 Mar;45(3):328-36. Unique Identifier : AIDSLINE MED/96173265; Peterson JD; Haskins K; Department of Immunology, University of Colorado Health Sciences; Center, Denver 80262, USA.; Transfer of an interleukin 2/interferon-gamma-secreting islet-specific CD4+ T-cell clone, BDC-6.9, in the immunodeficient NOD-scid mouse induces destruction of pancreatic beta-cells without help from host B-cells, CD4+ T-cells, or CD8+ T-cells. However, a second islet-specific T-cell clone, BDC-2.5, showing the same c
A profile of patients in six dental schools [letter]: J Dent Educ. 1996 Jan;60(1):79-80. Unique Identifier : AIDSLINE MED/96173482; Schneider DA; Hardwick KS; Niemcryk SJ; Duffy RE
PRO_LIGAND: an approach to de novo molecular design. 6. Flexible fitting in the design of peptides.: J Comput Aided Mol Des. 1995 Oct;9(5):381-95. Unique Identifier : AIDSLINE MED/96159750; Murray CW; Clark DE; Byrne DG; Proteus Molecular Design Ltd., Lyme Green Business Park,; Macclesfield, Cheshire, U.K.; This paper describes the further development of the functionality of our in-house de novo design program, PRO_LIGAND. In particular, attention is focused on the implementation and validation of the direct tweak method for the construction of conformationally flexible molecules, such as peptides, from molecular fragm
Levo-alpha-acetylmethadol (LAAM): clinical, research, and policy issues of a new pharmacotherapy for opioid addiction.: J Psychoactive Drugs. 1995 Jul-Sep;27(3):239-47. Unique Identifier : AIDSLINE MED/96116341; Prendergast ML; Grella C; Perry SM; Anglin MD; UCLA Drug Abuse Research Center 90024, USA.; A number of issues are relevant to the development and use of levo-alpha-acetylmethadol (LAAM) as a treatment alternative to methadone. A brief history of methadone maintenance treatment is provided and variants of standard methadone treatment are discussed. The history and current status of LAAm are discussed, as wel
To hang in the 'hood: description and analysis of outreach activities.: J Psychoactive Drugs. 1995 Jul-Sep;27(3):249-59. Unique Identifier : AIDSLINE MED/96116342; Elwood WN; Montoya ID; Richard AJ; Dayton CA; Affiliated Systems Corporation, Houston, Texas 77027, USA.; The unique, influential, and successful characteristics of outreach as a risk behavior reduction intervention among active drug users is examined. The history of outreach is posited as a delineation of roles, and the outreach process as one of communication and role enactment. The premise is that the outreach worker s
New anti-HIV drugs and treatment strategies buoy AIDS researchers [news]: JAMA. 1996 Feb 28;275(8):579-80. Unique Identifier : AIDSLINE MED/96174485; Stephenson J
HIV sexual risk-reduction interventions for African-American women [letter; comment]: JAMA. 1996 Feb 28;275(8):593; discussion 594-5. Unique Identifier : AIDSLINE MED/96174491; Winett RA; Kalichman SC
HIV sexual risk-reduction interventions for African-American women [letter; comment]: JAMA. 1996 Feb 28;275(8):593-4; discussion 594-5. Unique Identifier : AIDSLINE MED/96174492; Branson BM; Moore JS; Byers R
Maintaining low HIV seroprevalence among injecting drug users [letter; comment]: JAMA. 1996 Feb 28;275(8):596; discussion 597-8. Unique Identifier : AIDSLINE MED/96174495; Wong K; Lee S
Maintaining low HIV seroprevalence among injecting drug users [letter; comment]: JAMA. 1996 Feb 28;275(8):596-8. Unique Identifier : AIDSLINE MED/96174496; Morrison CL; Ruben SM
Identification of levels of maternal HIV-1 RNA associated with risk of perinatal transmission. Effect of maternal zidovudine treatment on viral load [see comments]: JAMA. 1996 Feb 28;275(8):599-605. Unique Identifier : AIDSLINE MED/96174498; Dickover RE; Garratty EM; Herman SA; Sim MS; Plaeger S; Boyer PJ; Keller M; Deveikis A; Stiehm ER; Bryson YJ; Department of Pediatrics, UCLA School of Medicine 90024, USA.; OBJECTIVE: To determine if there are levels of human immunodeficiency virus type 1 (HIV-1) associated with a high or low risk of perinatal transmission and to ascertain the mechanism by which zidovudine treatment reduces perinatal transmission. DESIGN: A nonrandomized prospective cohort study. SETTING: University medi
Neonatal characteristics in rapidly progressive perinatally acquired HIV-1 disease. The French Pediatric HIV Infection Study Group.: JAMA. 1996 Feb 28;275(8):606-10. Unique Identifier : AIDSLINE MED/96174499; Mayaux MJ; Burgard M; Teglas JP; Cottalorda J; Krivine A; Simon F; Puel J; Tamalet C; Dormont D; Masquelier B; Doussin A; Rouzioux C; Blanche S; Institut National de la Sante et de la Recherche Medicale,; Hopital Bicetre, Le Kremlin-Bicetre, France.; OBJECTIVE: To identify clinical and laboratory parameters at birth that are associated with the rapidly progressive form of human immunodeficiency virus type 1 (HIV-1) disease in children born to infected mothers. DESIGN: Multicenter, prospective study of infants born to HIV-seropositive mothers. SETTING: A total of 6
Quantifying HIV [editorial; comment]: JAMA. 1996 Feb 28;275(8):640-1. Unique Identifier : AIDSLINE MED/96174505; Landesman SH; Burns D
Update: mortality attributable to HIV infection among persons aged 25-44 years--United States, 1994. From the Centers for Disease Control.: JAMA. 1996 Mar 6;275(9):675-6. Unique Identifier : AIDSLINE MED/96173838
Immunomodulation by pycnogenol in retrovirus-infected or ethanol-fed mice.: Life Sci. 1996;58(5):PL 87-96. Unique Identifier : AIDSLINE MED/96173233; Cheshier JE; Ardestani-Kaboudanian S; Liang B; Araghiniknam M; Chung S; Lane L; Castro A; Watson RR; Department of Family and Community Medicine, University of; Arizona, Tucson 85724, USA.; Pycnogenol is a commercial mixture of bioflavonoids that exhibits antioxidative activity. The effects of dietary pycnogenol on immune dysfunction in normal mice as well as those fed ethanol or infected with the LP-BM5 murine retrovirus were determined. The ethanol consumption and retrovirus infection caused abnormalit
Purification and characterization of human immunodeficiency virus type 1 reverse transcriptase.: Methods Enzymol. 1995;262:130-44. Unique Identifier : AIDSLINE MED/96123638; Le Grice SF; Cameron CE; Benkovic SJ; Division of Infectious Diseases, Case Western Reserve University; School of Medicine, Cleveland, Ohio 44106-4984, USA.
Crystallization of human immunodeficiency virus type 1 reverse transcriptase with and without nucleic acid substrates, inhibitors, and an antibody Fab fragment.: Methods Enzymol. 1995;262:171-85. Unique Identifier : AIDSLINE MED/96123640; Clark AD Jr; Jacobo-Molina A; Clark P; Hughes SH; Arnold E; Center for Advanced Biotechnology and Medicine, Rutgers; University, Piscataway, New Jersey 08854-5638, USA.
Analyzing fidelity of DNA polymerases.: Methods Enzymol. 1995;262:217-32. Unique Identifier : AIDSLINE MED/96123643; Bebenek K; Kunkel TA; Laboratory of Molecular Genetics, National Institute of; Environmental Health Science, Research Triangle Park, North; Carolina 27709, USA.
Rationale for mutagenesis of DNA polymerase active sites: DNA polymerase alpha.: Methods Enzymol. 1995;262:294-303. Unique Identifier : AIDSLINE MED/96123648; Copeland WC; Dong Q; Wang TS; Department of Pathology, Stanford University School of Medicine,; California 94305-5324, USA.
Assays for retroviral reverse transcriptase.: Methods Enzymol. 1995;262:347-62. Unique Identifier : AIDSLINE MED/96123652; Telesnitsky A; Blain S; Goff SP; Department of Microbiology and Immunology, University of Michigan; Medical School, Ann Arbor 48109-0620, USA.
Images in clinical medicine. Histoplasmosis.: N Engl J Med. 1996 Mar 14;334(11):700. Unique Identifier : AIDSLINE MED/96176911; Daoust P; Schapiro B
Physicians' experience with the acquired immunodeficiency syndrome as a factor in patients' survival [see comments]: N Engl J Med. 1996 Mar 14;334(11):701-6. Unique Identifier : AIDSLINE MED/96175166; Kitahata MM; Koepsell TD; Deyo RA; Maxwell CL; Dodge WT; Wagner EH; Department of Medicine, University of Washington, Seattle, WA; 98122, USA.; BACKGROUND. Previous studies have found that patients with the acquired immunodeficiency syndrome (AIDS) who are admitted to hospitals that admit many such patients have lower mortality rates than patients in hospitals with less experience with AIDS. We examined the relation between physicians experience with AIDS an
Improving the outcomes of care for patients with human immunodeficiency virus infection [editorial; comment]: N Engl J Med. 1996 Mar 14;334(11):729-31. Unique Identifier : AIDSLINE MED/96175173; Volberding PA
Reviewing the behavioral science knowledge base on technology transfer. Introduction.: NIDA Res Monogr. 1995;155:1-20. Unique Identifier : AIDSLINE MED/96162681; Backer TE; David SL; Soucy G; Human Interaction Research Institute, Los Angeles, CA 90025-7007,; USA.
Assessing and enhancing readiness for change: implications for technology transfer.: NIDA Res Monogr. 1995;155:21-41. Unique Identifier : AIDSLINE MED/96162682; Backer TE; Human Interaction Research Institute, Los Angeles, CA 90025-7007,; USA.
Physical health problems associated with adolescent substance abuse.: NIDA Res Monogr. 1995;156:112-29. Unique Identifier : AIDSLINE MED/96162701; Kokotailo P; Department of Pediatrics, University of Wisconsin-Madison; 53792-4116, USA.
AIDS, drugs, and the adolescent.: NIDA Res Monogr. 1995;156:130-45. Unique Identifier : AIDSLINE MED/96162702; Steel E; National Institute on Drug Abuse, Rockville, MD 20852, USA.
Age-related effects of ectopic pituitary transplants on the activation of Ames dwarf mouse lymphocytes in vitro.: Proc Soc Exp Biol Med. 1996 Jan;211(1):87-93. Unique Identifier : AIDSLINE MED/96173398; Esquifino AI; Szary A; Brown-Borg HM; Bartke A; Departmento de Bioquimica y Biologia Molecular III, Facultad de; Medicina, Universidad Complutense, Madrid, Spain.; Prolactin (PRL), one of the anterior pituitary hormones, has been implicated in the development and maintenance of immune system function. The following experiments were conducted to evaluate age-related effects of PRL on immune system activity in a PRL-deficient mouse model, the Ames dwarf. Two- and ten-month-old dwa
[Peripheral neuropathies in HIV infection]: Rev Neurol (Paris). 1995 Oct;151(10):532-40. Unique Identifier : AIDSLINE MED/96167131; Gastaut JL; Service de Neurologie, Hopital Sainte-Marguerite, Marseille.
[T cell activation]: Ryumachi. 1995 Oct;35(5):853-61. Unique Identifier : AIDSLINE MED/96111838; Takase K; Saito T
Human immunodeficiency virus infection and human African trypanosomiasis: a case-control study in Cote d'Ivoire.: Trans R Soc Trop Med Hyg. 1995 Nov-Dec;89(6):639-43. Unique Identifier : AIDSLINE MED/96169596; Meda HA; Doua F; Laveissiere C; Miezan TW; Gaens E; Brattegaard K; de Muynck A; De Cock KM; OCCGE-Institut Pierre Richet, Bouake Cote d'Ivoire.; To assess the association between human immunodeficiency virus (HIV) infection and human African trypanosomiasis (HAT) in Cote d Ivoire , West Africa, a cross-sectional case-control study was conducted on 301 HAT patients recruited in the main foci of the country. For each HAT
Diffuse cutaneous infection caused by a presumed monoxenous trypanosomatid in a patient infected with HIV.: Trans R Soc Trop Med Hyg. 1995 Nov-Dec;89(6):644-6. Unique Identifier : AIDSLINE MED/96169597; Dedet JP; Roche B; Pratlong F; Cales-Quist D; Jouannelle J; Benichou JC; Huerre M; Laboratoire d'Ecologie Medicale et Pathologie Parasitaire,; Faculte de Medecine, Montpellier, France.; A patient infected with human immunodeficiency virus developed a diffuse cutaneous nodular syndrome. The parasite isolated from a skin nodule was studied by isoenzymatic characterization and transmission electron microscopy of both culture forms and those in the patient s skin biopsy. The parasite s ultrastructure was
Bovine leukaemia-virus infection in Costa Rica.: Zentralbl Veterinarmed [B]. 1995 Sep;42(7):385-90. Unique Identifier : AIDSLINE MED/96054817; Jimenez C; Bonilla JA; Dolz G; Rodriguez LR; Herrero L; Bolanos E; Cortez MR; Moreno E; Programa de Investigacion en Enfermedades Tropicales (PIET),; Escuela de Medicina Veterinaria, Universidad Nacional, Heredia,; Costa Rica.; The geographical distribution of bovine leukaemia-virus (BLV)-infected herds in Costa Rica and the isolation of BLV from cases of enzootic bovine leukosis are presented. It was found that BLV is prevalent throughout the country, affecting mostly dairy cattle (Bos taurus) located
Managing HIV disease after Delta [editorial]: BMJ. 1996 Mar 2;312(7030):521-2. Unique Identifier : AIDSLINE MED/96172026; Pinching AJ
HIV subtype may explain sexual transmission [news]: BMJ. 1996 Mar 2;312(7030):530-1. Unique Identifier : AIDSLINE MED/96177490; Dillner L
Continuing transmission of sexually transmitted diseases among patients infected with HIV-1 attending genitourinary medicine clinics in England and Wales.: BMJ. 1996 Mar 2;312(7030):539-42. Unique Identifier : AIDSLINE MED/96177495; Catchpole MA; Mercey DE; Nicoll A; Rogers PA; Simms I; Newham J; Mahoney A; Parry JV; Joyce C; Gill ON; Public Health Laboratory Service, Communicable Disease; Surveillance Centre, London.; OBJECTIVE--To determine whether those who are aware of being infected with HIV continue to adopt behaviours that place others at risk of HIV infection. DESIGN--Ongoing survey of current diagnosis of sexually transmitted disease and awareness of HIV infection among patients attending genitourinary medicine clinics. SET
French drug lottery idea causes uproar [news]: BMJ. 1996 Mar 9;312(7031):599-600. Unique Identifier : AIDSLINE MED/96179625; Dorozynski A
Distinct pattern of IL-2 and IFN-gamma gene expression in CD4 and CD8 T cells: cytofluorometric analysis at a single cell level using non-radioactive probes.: Cell Mol Biol (Noisy-le-grand). 1995 Nov;41(7):945-57. Unique Identifier : AIDSLINE MED/96170732; Morvan PY; Picot C; Dejour R; Genetet B; Genetet N; Faculte de Sciences Medicales et Pharmaceutiques, Laboratoire; de Microbiologie-Immunologie Pharmaceutique, Universite de; Rennes, France.; IL-2 and IFN-gamma gene expression was analyzed using an original method for in situ hybridization (ISH) with non-isotopic probes and flow cytometric analysis (FC). This method permits rapid detection of mRNA at a single cell level among in vitro activated human periph
Use of digoxigenin-labelled probes for the detection of B19 parvovirus DNA in batches of blood products.: Cell Mol Biol (Noisy-le-grand). 1995 Nov;41(7):985-8. Unique Identifier : AIDSLINE MED/96170737; Lefr`ere JJ; Mariotti M; Institut National de Transfusion Sanguine, Hopital; Saint-Antoine, Paris, France.; Being thermostable and non lipid-enveloped, the B19 parvovirus cannot be destroyed by the chemical and physical treatments presently used to inactivate lipid-enveloped viruses such as HIV, hepatitis C and B viruses in plasma derivatives. A polymerase chain reaction assay was used to detect B19 parvovirus DNA. Amplifie
Combination Antiretroviral Therapy for HIV Infection. Proceedings of an international symposium. Berlin, Germany, March 25-26, 1995.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;10 Suppl 1:v, S1-82. Unique Identifier : AIDSLINE MED/96179602
AIDS pathogenesis: from models to viral dynamics in patients.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;10 Suppl 1:S1-5. Unique Identifier : AIDSLINE MED/96173457; Nowak MA; Department of Zoology, University of Oxford, England.; The course of HIV infection usually follows a pattern in which the immune system is initially able to limit viral replication, but ultimately fails. It is proposed that disease progression is a consequence of viral replication and evolution within the host, the immune response providing the selection pressure for incr
The role of viral diversity in HIV pathogenesis.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;10 Suppl 1:S15-9. Unique Identifier : AIDSLINE MED/96173459; Goudsmit J; Human Retrovirus Laboratory, Academic Medical Centre, Amsterdam,; The Netherlands.; From the time of seroconversion, patients who retain a high viral load are known to progress more rapidly to AIDS than individuals who have lower levels of HIV. Increased viral load is accompanied by decreasing CD4 cell numbers, and CD4 cell counts are therefore widely used as a diagnostic marker or predictor of progr
HIV pathogenesis and treatment strategies.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;10 Suppl 1:S20-3. Unique Identifier : AIDSLINE MED/96173460; Vella S; Laboratory of Virology, Istituto Superiore di Sanita, Rome,; Italy.; HIV infection is a chronic progressive illness. This virus has a multiplicity of cellular targets and the virus-host relationship changes over time. The high daily rate of virus production is initially controlled by the immune system, but eventually the immune system fails to contain viral replication and individuals
Rapid screening of antiretroviral combinations.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;10 Suppl 1:S24-7. Unique Identifier : AIDSLINE MED/96173461; St Clair M; Pennington KN; Rooney J; Barry DW; Department of Virology, Burroughs Wellcome Co., North Carolina,; USA.; Increasing evidence supports the view that therapy with combinations of antiretroviral drugs provides greater and more sustained benefits in the treatment of HIV infection than either monotherapy or sequential therapy. As the number of licensed and developmental antiretroviral agents grows, in vitro analysis is increa
Viral resistance and the selection of antiretroviral combinations.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;10 Suppl 1:S28-33. Unique Identifier : AIDSLINE MED/96173462; Larder BA; Wellcome Research Laboratories, Beckenham, Kent, England.; Mounting scientific evidence suggests that viral replication and evolution of diversification, with the resulting emergence of variants including drug-resistant strains, is responsible for the gradual destruction of the immune system and is the mechanism of disease progression in HIV-infected patients. Monotherapy doe
Measuring viral load in the clinical setting.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;10 Suppl 1:S34-40. Unique Identifier : AIDSLINE MED/96173463; Harrigan R; Antiviral Therapeutic Research Unit, Wellcome Research; Laboratories, Beckenham, Kent, England.; The traditional approach of assessing new treatments in clinical end-point studies is becoming less viable for ethical and practical reasons. As more antiretroviral options become available and as treatment is commenced at earlier, asymptomatic stages of infection, alternative methods of assessing the efficacy of anti
Individualization of therapy using viral markers.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;10 Suppl 1:S41-6. Unique Identifier : AIDSLINE MED/96173464; Merigan T; Stanford University School of Medicine, California 94305, USA.; Early intervention with a combination of drugs is generally accepted as the way forward in the management of HIV infection. In general, combination therapy should include agents that demonstrate additive or synergistic activity, do not have similar side-effect profiles
Current HIV clinical trial design issues.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;10 Suppl 1:S47-51. Unique Identifier : AIDSLINE MED/96173465; Lange JM; Department of Internal Medicine, Academic Medical Centre,; Amsterdam, The Netherlands.; Aids-free time and survival time of people with HIV infection has gradually increased since the first clinical trial of zidovudine( AZT ) in 1987. This change in pattern of disease course has, however, made it difficult for current clinical trials to re
Studies of zidovudine in combination with didanosine and zalcitabine.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;10 Suppl 1:S52-6. Unique Identifier : AIDSLINE MED/96173468; Jablonowski H; Department of Gastroenterology, Heinrich-Heine Universitat,; Dusseldorf,Germany.; A number of antiviral agents have been developed to treat individuals with HIV infection. Monotherapy treatment with the licensed reverse transcriptase (RT) inhibitors zidovudine ( AZT ), zalcitabine (
Zidovudine and lamivudine: results of phase III studies.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;10 Suppl 1:S57. Unique Identifier : AIDSLINE MED/96173469; Staszewski S; Goethe-Universitat, Frankfurt, Germany.; It has become apparent that the beneficial effects of zidovudine ( AZT ) and other antivirals will not continue indefinitely. However, synergistic activity of lamivudine ( 3TC ) in combin
Rationale and experience with reverse transcriptase inhibitors and protease inhibitors.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;10 Suppl 1:S58-61. Unique Identifier : AIDSLINE MED/96173466; Vella S; Laboratory of Virology, Istituto Superiore di Sanita, Rome Italy.; The majority of antiretroviral agents used in the treatment of HIV are targeted at the HIV reverse transcriptase (RT) enzyme. In a continuing effort to develop more effective antiviral regimens, drugs that target other specific enzymes in the virus replication cycle are under development. A promising new class of drug
Pathogenic insights from studies of lymphoid tissue from HIV-infected individuals.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;10 Suppl 1:S6-14. Unique Identifier : AIDSLINE MED/96173458; Pantaleo G; Cohen OJ; Schwartzentruber DJ; Graziosi C; Vaccarezza M; Fauci AS; National Institute of Allergy and Infectious Diseases, Laboratory; of Immunoregulation, National Institutes of Health, Bethesda, MD; 20892, USA.; Studies of lymphoid tissue from HIV-infected individuals have provided critical insights into the pathogenesis of HIV disease. Systemic dissemination of virus via the lymphatic system occurs at a very early stage after infection. Explosive viral replication within lymphoid tissue ensues, before the development of cell
Combination therapy from a clinician's perspective.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;10 Suppl 1:S62-8. Unique Identifier : AIDSLINE MED/96173470; Goebel FD; Ludwig-Maximilians-Universitat, Munich, Germany.; A number of important scientific questions have been answered in recent years concerning how HIV causes disease and whether combinations of antiretroviral agents might be more effective than monotherapies. However, a considerable number of questions remain unanswered regarding when to start treatment and what regimen
Therapeutic interventions in primary HIV infection.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;10 Suppl 1:S69-76. Unique Identifier : AIDSLINE MED/96173467; Kinloch-de Loes S; Perrin L; Laboratory of Virology, Geneva University Hospital, Switzerland.
Triple combinations: present and future.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;10 Suppl 1:S77-82. Unique Identifier : AIDSLINE MED/96173471; Lange JM; Department of Internal Medicine, Academic Medical Centre,; Amsterdam, the Netherlands.; Three or more therapeutic agents have commonly been used to treat chronic infections and many malignant diseases. It is clear that monotherapy treatment of HIV infection, although effective in the short term, is not a viable long-term management option because of incomplete suppression of viral replication and the sub
Optimal self-cleavage activity of the hepatitis delta virus RNA is dependent on a homopurine base pair in the ribozyme core.: RNA. 1995 Dec;1(10):1061-70. Unique Identifier : AIDSLINE MED/96166714; Been MD; Perrotta AT; Department of Biochemistry, Duke University Medical School,; Durham, North Carolina 27710, USA.; A non-Watson-Crick G.G interaction within the core region of the hepatitis delta virus (HDV) antigenomic ribozyme is required for optimal rates of self-cleavage activity. Base substitutions for either one or both G s revealed that full activity was obtained only when both G s were replaced with A s. At those positions
Rapid automated determination of adenosine deaminase and lysozyme for differentiating tuberculous and nontuberculous pleural effusions.: Clin Chem. 1996 Feb;42(2):218-21. Unique Identifier : AIDSLINE MED/96173893; Villena V; Navarro-Gonzalvez JA; Garcia-Benayas C; Manzanos JA; Echave J; Lopez-Encuentra A; Arenas Barbero J; Servicio de Neumologia, Hospital 12 de Octubre Avda, Madrid,; Spain.; The catalytic concentration of pleural adenosine deaminase (ADA) and the ratio of pleural lysozyme (PL) to serum lysozyme (SL) were measured in consecutive patients (49 tuberculous and 179 nontuberculous) with two automated procedures in a Hitachi 717 analyzer. Using sensitivity and specificity curves, we established
Retroviral transmission in bone allotransplantation. The effects of tissue processing.: Clin Orthop. 1996 Mar;(324):275-82. Unique Identifier : AIDSLINE MED/96175319; Nemzek JA; Arnoczky SP; Swenson CL; Laboratory for Comparative Orthopaedic Research, College of; Veterinary Medicine, Michigan State University, East Lansing, MI; 48824-1314, USA.; The transmission of a retrovirus through transplantation of processed bone allografts was studied using the feline leukemia virus. The long bones of 4 previously infected donor cats were harvested and assigned to 1 of 3 treatment groups: single freeze/thaw cycle, double freeze/thaw cycle, or double freeze/thaw cycle w
Short-term changes in lymphocytes after placement of silver amalgam restorations in healthy subjects.: Dent Mater. 1995 Sep;11(5):323-6. Unique Identifier : AIDSLINE MED/96177064; Osorio E; Toledano M; Bravo M; Osorio R; Area of Dental Materials, School of Dentistry, University of; Granada, Spain.; OBJECTIVES: The purpose of this study was to evaluate the changes in lymphocyte subpopulations that have led to immune system alterations after amalgam restorations were placed. METHODS: A controlled, quasi-experimental pretest-posttest design was used to investigate the immune effects of silver amalgam restorations i
A man with shrub leg.: Hosp Pract (Off Ed). 1996 Jan 15;31(1):58-9. Unique Identifier : AIDSLINE MED/96173884; DeMasi R; Brown M; Medical Service, James A. Haley Veterans Affairs Medical Center,; Tampa, Florida, USA.; A 39-year-old man with confirmed HIV infection of six years duration presented with painful swelling of his right lower leg. Two weeks earlier, he had scratched the leg on a shrub.
CD4low TCRint thymocytes do not belong to the CD8 lineage maturation pathway.: J Immunol. 1996 Mar 1;156(5):1743-47. Unique Identifier : AIDSLINE MED/96173759; Lucas B; Marodon G; Penit C; INSERM Unit 345, Necker Institute, Paris, France.; Thymocytes with a low expression of CD4 and an intermediate density of the TCR (CD4low TCRint) were analyzed for phenotype, MHC dependence, production kinetics, and TCR repertoire to investigate their position in the intrathymic T cell maturation process. Comparison of normal and MHC-deficient mice showed that the CD4
IL-12 produced by antigen-presenting cells induces IL-2-independent proliferation of T helper cell clones.: J Immunol. 1996 Mar 1;156(5):1748-55. Unique Identifier : AIDSLINE MED/96173760; Maruo S; Toyo-oka K; Oh-hora M; Tai XG; Iwata H; Takenaka H; Yamada S; Ono S; Hamaoka T; Kobayashi M; Wysocka M; Trinchieri G; Fujiwara H; Biomedical Research Center, Osaka University Medical School,; Japan.; We investigated the role of IL-12 in proliferation of various Th cell clones (class II-alloreactive (4-86 and 4-55) and keyhole limpet hemocyanin + self I-Ek-reactive (9-16)) following stimulation with Ag on APCs. These clones proliferated in response to stimulation with rIL-2, rIL-12, or Ag/APC. The proliferation ind
Human IL-13 production is negatively influenced by CD3 engagement. Enhancement of IL-13 production by cyclosporin A.: J Immunol. 1996 Mar 1;156(5):1818-23. Unique Identifier : AIDSLINE MED/96173769; van der Pouw Kraan TC; Boeije LC; Troon JT; Rutschmann SK; Wijdenes J; Aarden LA; Department of Autoimmune Diseases, Central Laboratory of the; Netherlands Red Cross Blood Transfusion Service, Amsterdam.; IL-13, a T cell-derived cytokine, shares many of its biologic activities with the Th2 cytokine IL-4, including induction of a class switch to IgE and anti-inflammatory properties. Its potential impact on development of Th2 responses makes it interesting to determine how the production of IL-13 is regulated and which c
TCRV beta 7+ Th2 cells mediate UVB-induced suppression of murine contact photosensitivity by releasing IL-10.: J Immunol. 1996 Mar 1;156(5):1824-31. Unique Identifier : AIDSLINE MED/96173770; Yagi H; Tokura Y; Wakita H; Furukawa F; Takigawa M; Department of Dermatology, Hamamatsu University School of; Medicine, Japan.; In murine contact photosensitivity, a cutaneous delayed-type hypersensitivity reaction, preirradiation of the photosensitization site with UVB induced Ag-specific, afferent limb-acting, CD4+CD8- suppressor T cells (Ts). The present study examined usage of TCR V beta and production of immunosuppressive cytokines in Ts
Characterization of an intronless CD4 minigene expressed in mature CD4 and CD8 T cells, but not expressed in immature thymocytes.: J Immunol. 1996 Mar 1;156(5):1873-9. Unique Identifier : AIDSLINE MED/96173776; Salmon P; Boyer O; Lores P; Jami J; Klatzmann D; Laboratory of Biology and Therapeutics of Immunity Pathology,; Pitie-Salpetriere Hospital, Paris, France.; The expression of the CD4 gene undergoes a complex pattern of regulation during T cell development. Results obtained in transgenic mice suggest that a combination of proximal enhancer and a silencer from the CD4 gene is sufficient to obtain a developmentally controlled expression along T cell maturation. We generated
Interference between human herpesvirus 7 and HIV-1 in mononuclear phagocytes.: J Immunol. 1996 Mar 1;156(5):2004-8. Unique Identifier : AIDSLINE MED/96173793; Crowley RW; Secchiero P; Zella D; Cara A; Gallo RC; Lusso O; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, MD 20894, USA.; Human herpesvirus 7 (HHV-7) uses CD4 as a cellular membrane receptor and thereby interferes with infection of CD4+ T cells by HIV-1. We studied the interactions between HHV-7 and a macrophage-tropic HIV-1 isolate (HIV-1BaL) in terminally differentiated human peripheral blood monocyte-derived macrophages, another criti
Human T-cell leukemia virus type I tax transactivates the interleukin-6 gene in human rheumatoid synovial cells.: J Rheumatol. 1995 Nov;22(11):2049-54. Unique Identifier : AIDSLINE MED/96157783; Mori N; Shirakawa F; Abe M; Kamo Y; Koyama Y; Murakami S; Shimizu H; Yamamoto K; Oda S; Eto S; First Department of Internal Medicine, School of Medicine,; University of Occupational and Environmental Health, Kitakyushu,; Japan.; OBJECTIVE: To determine the effect of the human T cell leukemia virus type I (HTLV-I) tax gene on interleukin-6 (IL-6) production and gene transcription in synovial cells, we established the synovial cell line, E-11, from a patient with rheumatoid arthritis. METHODS: E-11 cells were transfected with tax expression vec
Is HIV infection contraindication to the use of methotrexate in psoriatic arthritis? [letter]: J Rheumatol. 1995 Nov;22(11):2191. Unique Identifier : AIDSLINE MED/96157814; Masson C; Chennebault JM; Leclech C
A man with alcoholism and HIV infection, 1 year later [comment]: JAMA. 1996 Apr 3;275(13):1029. Unique Identifier : AIDSLINE MED/96176717; Delbanco TL; Daley J; Walzer J
Demographic determinants of hepatitis C virus seroprevalence among blood donors.: JAMA. 1996 Apr 3;275(13):995-1000. Unique Identifier : AIDSLINE MED/96176711; Murphy EL; Bryzman S; Williams AE; Co-Chien H; Schreiber GB; Ownby HE; Gilcher RO; Kleinman SH; Matijas L; Thomson RA; Nemo GJ; Department of Laboratory Medicine, University of California, San; Francisco 94143-0884, USA.; OBJECTIVE: To measure demographic determinants of hepatitis C virus (HCV) seroprevalence among blood donors in the United States . DESIGN: Cross-sectional epidemiological study. SETTING: Five blood centers in different regions of the United States. SUBJECTS: A total of 862,398 consecuti
Euthanasia and physician-assisted suicide in homosexual men with AIDS [see comments]: Lancet. 1996 Feb 24;347(9000):499-504. Unique Identifier : AIDSLINE MED/96174707; Bindels PJ; Krol A; van Ameijden E; Mulder-Folkerts DK; van den Hoek JA; van Griensven GP; Coutinho RA; Municipal Health Service, Department of Public Health, Amsterdam,; Netherlands.; BACKGROUND: In the Netherlands a nationwide study has shown that, in 38% of deaths, there have been medical decisions concerning the end of life (MDEL); 2.1% of all deaths were brought about by euthanasia or physician- assisted suicide (PAS). We investigated the incidence of M
HIV subtypes raise vaccine anxieties [news]: Lancet. 1996 Mar 2;347(9001):603. Unique Identifier : AIDSLINE MED/96175020; Rowe PM
South Africa's AIDS play provokes controversy.: Lancet. 1996 Mar 2;347(9001):610. Unique Identifier : AIDSLINE MED/96175023; Lee N
Vertical transmission of hepatitis G [letter] [see comments]: Lancet. 1996 Mar 2;347(9001):615-6. Unique Identifier : AIDSLINE MED/96175032; Feucht HH; Zollner B; Polywka S; Laufs R
Protease inhibitors fly through FDA [news]: Lancet. 1996 Mar 9;347(9002):678. Unique Identifier : AIDSLINE MED/96175909; Barnett AA
Risk of HIV transmission in infected US military personnel [letter; comment]: Lancet. 1996 Mar 9;347(9002):697. Unique Identifier : AIDSLINE MED/96175940; Temoshok LR; Patterson TL
Risk of HIV transmission in infected US military personnel [letter; comment]: Lancet. 1996 Mar 9;347(9002):697-8. Unique Identifier : AIDSLINE MED/96175941; Ruppach H; Knechten H; Jager H; Rubsamen-Waigmann H; Dietrich U
HIV/AIDS education and prevention programs for adults in prisons and jails and juveniles in confinement facilities--United States, 1994.: MMWR Morb Mortal Wkly Rep. 1996 Apr 5;45(13):268-71. Unique Identifier : AIDSLINE MED/96176753; By the end of 1994, at least 4588 adult inmates of U.S. prisons and jails had died as a result of acquired immunodeficiency syndrome (AIDS), and during 1994, at least 5279 adult inmates with AIDS were incarcerated in prisons and jails (1). Periodically conducted national surveys instituted in 1985 (2) and sponsored by
Tuberculosis, AIDS, and death among substance abusers on welfare in New York City [see comments]: N Engl J Med. 1996 Mar 28;334(13):828-33. Unique Identifier : AIDSLINE MED/96176276; Friedman LN; Williams MT; Singh TP; Frieden TR; Pulmonary and Critical Care Section, Yale University School of; Medicine, New Haven, CT, USA.; BACKGROUND. In New York City, the incidence of tuberculosis has more than doubled during the past decade. We examined the incidence of tuberculosis and the acquired immunodeficiency syndrome (AIDS) and the rate of death from all causes in a very-high-risk group--indigent subjects who abuse drugs, alcohol, or both. MET
Social vulnerability and death by infection [editorial; comment]: N Engl J Med. 1996 Mar 28;334(13):859-60. Unique Identifier : AIDSLINE MED/96176283; Fineberg HV; Wilson ME
The risk of HIV transmission by screened blood [letter; comment]: N Engl J Med. 1996 Apr 11;334(15):992; discussion 993. Unique Identifier : AIDSLINE MED/96177536; Kinloch S; Perrin L; Hirschel B
The risk of HIV transmission by screened blood [letter; comment]: N Engl J Med. 1996 Apr 11;334(15):992; discussion 993. Unique Identifier : AIDSLINE MED/96177535; Vyas GN; Rawal BD
The risk of HIV transmission by screened blood [letter; comment]: N Engl J Med. 1996 Apr 11;334(15):993. Unique Identifier : AIDSLINE MED/96177533; Carlson B
NIH agrees to temporary by-pass of AIDS office in allocation of grants [news]: Nature. 1996 Feb 8;379(6565):475. Unique Identifier : AIDSLINE MED/96170018; Wadman M
Legal action 'may end search for truth' in Canada's HIV inquiry [news]: Nature. 1996 Feb 8;379(6565):479. Unique Identifier : AIDSLINE MED/96170021; Spurgeon D
Interleukin 4 (IL-4) and IL-6-producing memory T-cells in peripheral blood and gingival tissue in periodontitis patients with high serum antibody titers to Porphyromonas gingivalis.: Oral Microbiol Immunol. 1995 Oct;10(5):304-10. Unique Identifier : AIDSLINE MED/96179247; Aoyagi T; Sugawara-Aoyagi M; Yamazaki K; Hara K; Department of Periodontalogy, Niigata University School of; Dentistry, Japan.; We assessed cytokine production and proliferation of memory T-cells that were isolated from peripheral blood of adult periodontitis patients with high anti-Porphyromonas gingivalis titer. Memory T-cells were stimulated with P. gingivalis lipopolysaccharide, sonicates and formalin-killed whole cells. Interleukin 4(IL-4
99mTc-trimethyl-BrIDA scintigraphy in HIV-related cholangiopathy.: Nuklearmedizin. 1995 Dec;34(6):252-4. Unique Identifier : AIDSLINE MED/96151003; Bair HJ; Behr T; Rubbert A; Becker W; Wolf F; Department of Nuclear Medicine, University of Erlangen-Nurnberg,; Germany.; A HIV-infected 37-year-old man with diffuse mid-abdominal pain and elevated liver enzymes was sequentially studied by sonography, computed tomography (CT), 99mTc-trimethyl-BrIDA scintigraphy and endoscopic retrograde cholangiopancreatography (ERCP). CT and sonography did not lead to a final diagnosis. Cholescintigraph
[Extracellular matrix proteins as regulators of the immune response]: Pol Arch Med Wewn. 1995 Aug;94(2):173-7. Unique Identifier : AIDSLINE MED/96166484; Matysiak W; Stepien-Sopniewska B; Mrowiec T; Zakladu Immunologii Klinicznej AM w Lublinie.
[Long-term asymptomatic HIV infection--pathogenetic aspects]: Pol Arch Med Wewn. 1995 Sep;94(3):275-82. Unique Identifier : AIDSLINE MED/96166496; Radkowski M; Slusarczyk J; Zaklad Immunopatologii, Instytut Chorob Zakaznych i; Pasozytniczych Akademii Medycznej w Warszawie.
Human immunodeficiency virus infection and multilocular thymic cysts.: Radiology. 1996 Feb;198(2):377-9. Unique Identifier : AIDSLINE MED/96148785; Leonidas JC; Berdon WE; Valderrama E; Neveling U; Schuval S; Weiss SJ; Hilfer C; Godine L; Department of Radiology, Schneider Children's Hospital of Long; Island Jewish Medical Center, Albert Einstein College of; Medicine, New Hyde Park, NY 11040, USA.; PURPOSE: Pathologic changes of the thymus, often seen in children with the human immunodeficiency virus (HIV), reflect direct invasion by the virus, followed by involution of the gland. A previously unknown form of thymic response to HIV infection, that of a multilocular thymic cyst, is reported. MATERIALS AND METHODS
Gallo's institute at the last hurdle [news]: Science. 1996 Mar 8;271(5254):1359. Unique Identifier : AIDSLINE MED/96173941; Marshall E
Induction of TH1 and TH2 immunity in neonatal mice [see comments]: Science. 1996 Mar 22;271(5256):1728-30. Unique Identifier : AIDSLINE MED/96179675; Forsthuber T; Yip HC; Lehmann PV; Department of Pathology, Case Western Reserve University,; Cleveland, OH 44106-4943, USA.; The neonatal period has been thought of as a window in ontogeny, during which the developing immune system is particularly susceptible to tolerization. In the present study, the classic system for induction of neonatal tolerance to protein antigens was reexamined in mice. The presumably tolerogenic protocol was found
Attenuated HIV vaccine: caveats [letter; comment]: Science. 1996 Mar 29;271(5257):1790-2. Unique Identifier : AIDSLINE MED/96175571; Ruprecht RM; Baba TW; Liska V
Inhibition of HIV-1 replication in lymphocytes by mutants of the Rev cofactor eIF-5A.: Science. 1996 Mar 29;271(5257):1858-60. Unique Identifier : AIDSLINE MED/96175583; Bevec D; Jaksche H; Oft M; Wohl T; Himmelspach M; Pacher A; Schebesta M; Koettnitz K; Dobrovnik M; Csonga R; Lottspeich F; Hauber J; Sandoz Research Institute, Department of Immunodermatology,; Vienna, Austria.; Eukaryotic initiation factor 5A(eIF-5A) is a cellular cofactor require d for the function of the human immunodeficiency virus type-1 (HIV-1) Rev trans-activator protein. The majority of a set of eIF-5A mutants did not support growth of yeast cells having an inactivated genomic copy of eIF-5A, indicating that the intro
Antisense phosphorothioates as antivirals against human immunodeficiency virus (HIV) and hepatitis B virus (HBV).: Toxicol Lett. 1995 Dec;82-83:435-8. Unique Identifier : AIDSLINE MED/96170126; Matsukura M; Koike K; Zon G; Department of Child Development, Kumamoto University School of; Medicine, Japan.; For the past 10 years we have focused on the development of antisense treatments against viral infections such as human immunodeficiency virus (HIV) and hepatitis B virus (HBV). We have demonstrated that phosphorothioate oligomers have in vitro anti-HIV activities and in vivo anti-HBV activity. In vitro anti-HIV activ
Health care needs of persons with HIV/AIDS in various settings.: West J Nurs Res. 1995 Dec;17(6):647-71. Unique Identifier : AIDSLINE MED/96166628; Berk RA; Baigis-Smith J; Nanda JP; School of Nursing, Johns Hopkins University, USA.; This study describes the psychosocial and physiological health care needs of persons with HIV/AIDS in hospital, outpatient, home care, and long-term care settings. A cross-sectional descriptive design with 386 patients selected from the four settings was used to test between-setting differences on Healthcare Needs Sca
Molecular modelling of glycoproteins by homology with non-glycosylated protein domains, computer simulated glycosylation and molecular dynamics.: Adv Exp Med Biol. 1995;376:37-45. Unique Identifier : AIDSLINE MED/96167348; Renouf DV; Hounsell EF; University College London, Department of Biochemistry and; Molecular Biology, United Kingdom.; OBJECTIVES: This study aims to visualise glycoproteins by computer graphics molecular modelling in order to research the dynamics of the oligosaccharide chains, determine their affects on protein conformation, antigenicity and function and to characterise oligosaccharide recognition determinants. With respect to the l
Unilateral optic neuritis caused by Histoplasma capsulatum in a patient with the acquired immunodeficiency syndrome.: Am J Ophthalmol. 1996 Mar;121(3):324-6. Unique Identifier : AIDSLINE MED/96176841; Yau TH; Rivera-Velazquez PM; Mark AS; Cytryn AS; Levy CS; Shmookler BM; Kolsky MP; Department of Ophthalmology, Washington Hospital Center, District; of Columbia 20010, USA.; PURPOSE: To evaluate the potential of Histoplasma capsulatum to cause optic neuritis in the setting of the acquired immunodeficiency syndrome (AIDS). METHODS: We examined a 35-year-old man with a history of AIDS and disseminated histoplasmosis who developed a unilateral progressive optic neuritis of enigmatic origin.
Increased plasma rifabutin levels with concomitant fluconazole therapy in HIV-infected patients.: Ann Intern Med. 1996 Mar 15;124(6):573-6. Unique Identifier : AIDSLINE MED/96175656; Trapnell CB; Narang PK; Li R; Lavelle JP; Georgetown University Medical Center, Washington, D.C., USA.; OBJECTIVE: To determine the effect of fluconazole on rifabutin pharmacokinetics. DESIGN: An open-label, crossover, phase 1 trial. SETTING: Outpatient clinical research center at a university medical center in Washington, D.C. PATIENTS: 12 persons with human immunodeficiency virus (HIV) infection whose CD4 lymphocyte c
Induction of adrenal suppression by megestrol acetate [letter]: Ann Intern Med. 1996 Mar 15;124(6):613. Unique Identifier : AIDSLINE MED/96175665; Khoo SH; Wilkins EG; Abbott M
Lymphopoiesis, apoptosis, and immune amnesia.: Ann N Y Acad Sci. 1995 Dec 29;770:213-26. Unique Identifier : AIDSLINE MED/96170308; Donnenberg AD; Margolick JB; Donnenberg VS; University of Pittsburgh School of Medicine, Department of; Medicine, Pennsylvania 15213, USA.; Bone marrow transplant recipients have a functional T-cell deficit long after T-cell counts have returned to normal levels. Early after BMT, T-cell phenotype is predominantly CD45RO+/CD29high/HLA-DR+/CD38high. This profile is associated with activated memory cells in healthy subjects, but also appears on the earliest
Steroid hormone regulation of a polyclonal TH2 immune response.: Ann N Y Acad Sci. 1995 Dec 29;774:323-5. Unique Identifier : AIDSLINE MED/96170359; Padgett DA; Sheridan JF; Loria RM; Department of Medical Microbiology, Ohio State University,; Columbus 43210, USA.
Hyperbaric oxygen therapy as adjunctive therapy for PCP.: AIDS Patient Care. 1995 Dec;9(6):270. Unique Identifier : AIDSLINE AIDS/96156747; Zebley J; Altieri R; Reillo M; Geckler R; Life Force, Inc., Baltimore, MD, USA.
Cosmetic control of parotid gland hypertrophy using radiation therapy.: AIDS Patient Care. 1995 Dec;9(6):271-5. Unique Identifier : AIDSLINE AIDS/96156748; Beitler JJ; Smith RV; Silver CE; Mitnick R; Habib I; Bello JA; Davis LW; Department of Radiation Oncology, Montefiore Medical Center,; Bronx, NY, USA.
A technique for accurate use of CD4+ cell counts.: AIDS Patient Care. 1995 Dec;9(6):276-80. Unique Identifier : AIDSLINE AIDS/96156749; Vedhara K; Nott KH; Richards SM; Bradbeer C; Davidson EA; Ong EL; Snow MH; Department of Medicine, University of Wales College of Medicine,; Cardiff, UK.; Despite uncertainty over their reliability, CD4+ cell counts are used extensively in both clinical and research settings to document progression in HIV infection. We examined, therefore, whether the performance of a simple statistical test would facilitate greater accuracy in the use of this marker. CD4+ cell count da
Rural physicians: a survey analysis of HIV/AIDS patient management.: AIDS Patient Care. 1995 Dec;9(6):281-9. Unique Identifier : AIDSLINE AIDS/96156750; Samuels ME; Shi L; Stoskoph CH; Richter DL; Baker SL; Sy FS; Department of Health Administration, School of Public Health,; University of South Carolina, Columbia, USA.; Primary care physicians in South Carolina were asked about their knowledge, attitudes, beliefs, and services provided to HIV/AIDS patients. The study focused on conditions under which physicians would provide additional services in an effort to develop more effective state policies regarding HIV/AIDS. There was a 66 p
Meal consumption of AIDS patients and home delivered meals.: AIDS Patient Care. 1995 Dec;9(6):290-2. Unique Identifier : AIDSLINE AIDS/96156751; Hannema C; Chan MM; Canty DJ; Gay Men's Health Crisis, New York, NY, USA.
Following the patient's wishes: living wills and powers of attorney.: AIDS Patient Care. 1995 Dec;9(6):293-6. Unique Identifier : AIDSLINE AIDS/96156752; Hacker C; Watson JR; Grimes RM; AIDS Education and Training Center for Texas and Oklahoma,; University of Texas-Houston Health Science Center, School of; Public Health, USA.
Access to health care and geographic mobility of HIV/AIDS patients.: AIDS Patient Care. 1995 Dec;9(6):297-302. Unique Identifier : AIDSLINE AIDS/96156753; Hogg RS; Schechter MT; Schilder A; Le R; Strathdee SA; Goldstone IL; O'Shaughnessy MV; British Columbia Centre for Excellence in HIV/AIDS, St. Paul's; Hospital/University of British Columbia, Vancouver, Canada.; OBJECTIVE. To determine the patterns and determinants of mobility in persons with HIV infection or AIDS on a population basis. DESIGN. Descriptive cross-sectional population health study. TARGET POPULATION. 650 full members (i.e., HIV-positive) of the Vancouver Persons with AIDS Society who were residents of British C
Anti-HIV therapy lowers risk of AIDS, death in patients with intermediate-stage HIV disease [news]: AIDS Patient Care. 1995 Dec;9(6):303. Unique Identifier : AIDSLINE AIDS/96156754
Resistance slow to emerge in combination therapy [news]: AIDS Patient Care. 1995 Dec;9(6):303-4. Unique Identifier : AIDSLINE AIDS/96156755
Stanford study of saquinavir reveals low toxicities [news]: AIDS Patient Care. 1995 Dec;9(6):304-5. Unique Identifier : AIDSLINE AIDS/96156756
Invirase program expands [news]: AIDS Patient Care. 1995 Dec;9(6):305. Unique Identifier : AIDSLINE AIDS/96156758
Phase I/II clinical trial for PRO 2000 begins [news]: AIDS Patient Care. 1995 Dec;9(6):305. Unique Identifier : AIDSLINE AIDS/96156757
DOXIL approved by FDA [news]: AIDS Patient Care. 1995 Dec;9(6):306. Unique Identifier : AIDSLINE AIDS/96156760
Oral cytovene an effective alternative to IV [news]: AIDS Patient Care. 1995 Dec;9(6):306. Unique Identifier : AIDSLINE AIDS/96156759
Cryptosporidium clinical trial started [news]: AIDS Patient Care. 1995 Dec;9(6):306-7. Unique Identifier : AIDSLINE AIDS/96156761
Medi-Cal reimburses for growth hormone [news]: AIDS Patient Care. 1995 Dec;9(6):307. Unique Identifier : AIDSLINE AIDS/96156762
Vaccine can increase growth of HIV [news]: AIDS Patient Care. 1995 Dec;9(6):307-8. Unique Identifier : AIDSLINE AIDS/96156763
Ganciclovir prophylaxis for CMV disease infrequently associated with viral resistance [news]: AIDS Patient Care. 1995 Dec;9(6):308. Unique Identifier : AIDSLINE AIDS/96156764
NIOSH certification of respirators will save health care industry millions [news]: AIDS Patient Care. 1995 Dec;9(6):309. Unique Identifier : AIDSLINE AIDS/96156765; Makulowich GS
OSHA revises booklet on personal protective equipment [news]: AIDS Patient Care. 1995 Dec;9(6):309-10. Unique Identifier : AIDSLINE AIDS/96156766; Makulowich GS
FDA approves latex sensitivity test [news]: AIDS Patient Care. 1995 Dec;9(6):310. Unique Identifier : AIDSLINE AIDS/96156767; Makulowich GS
Study shows differences in double-gloving by general and orthopedic surgeons [news]: AIDS Patient Care. 1995 Dec;9(6):310. Unique Identifier : AIDSLINE AIDS/96156768; Makulowich GS
Clinical information about HIV/AIDS on the Internet [news]: AIDS Patient Care. 1995 Dec;9(6):311-2. Unique Identifier : AIDSLINE AIDS/96156769; Makulowich JS
Shame, gay men, and HIV disease. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: Focus. 1995 Apr;10(5):1-4. Unique Identifier : AIDSLINE AIDS/96700390; Sabar S; Clinishare Home Health, Chatsworth, CA.; Mental health professionals working with people with HIV disease are often confronted by the patients feelings of shame and should be prepared to recognize and treat what can sabotage the openness crucial to the therapeutic process. Shame is unlike guilt in that instead of being a transgression against some moral cod
Abuse and HIV-related risk. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: Unique Identifier : AIDSLINE AIDS/96700391; Benson JD; University of California San Francisco, AIDS Clinic, San; Francisco, CA.; Research has been conducted on the effects of childhood abuse that may lead to HIV risk-taking behaviors in adolescence and adulthood. There is evidence of a higher incidence of childhood abuse among HIV-infected individuals and those at highest risk, but not enough evidence to confirm childhood abuse as a root cause
D4T: new clinical data confirms benefit. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Treat News. 1995 May 5;(no 222):1-3. Unique Identifier : AIDSLINE AIDS/96700430; James JS; The results of a study sponsored by Bristol-Myers Squibb , presented at the Eighth International Conference on Antiviral Research, April 23-8, 1995, show that patients who have been using AZT did significantly better in
Stanford researchers find loss of naive T-cells. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Treat News. 1995 May 5;(no 222):3-5. Unique Identifier : AIDSLINE AIDS/96700431; James JS; Two studies by researchers at Stanford University may force beliefs about the pathogenesis of HIV disease to be reevaluated. The researchers reported a selective loss of naive CD4 and CD8 cells in both HIV-infected adults and children, respectively. Therefore, AIDS may be a disease not of loss of CD4 cells, but of los
ICC trials: new option on laboratory tests. Inter-Company Collaboration for AIDS Drug Development. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Treat News. 1995 May 5;(no 222):5. Unique Identifier : AIDSLINE AIDS/96700432; The Inter-Company Collaboration for AIDS Drug Development (ICC) has recently made several changes for volunteers enrolling in its 001 trial. After several complaints from volunteers who were asked to pay for pre-screening blood tests, the ICC, a consortium of 15 major pharmaceutical companies, is now providing an opti
3TC expanded access program: new requirement for CD4 less than 100. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Treat News. 1995 May 5;(no 222):5. Unique Identifier : AIDSLINE AIDS/96700433; Glaxo, the manufacturer of 3TC , has announced that it is limiting enrollment for its expanded access program. Due to the increased demand for the drug after reports of good results with the combination of 3TC and
Agouron protease inhibitor AG1343: activity reported. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Treat News. 1995 May 5;(no 222):6. Unique Identifier : AIDSLINE AIDS/96700434; James JS; Early study results show that the protease inhibitor AG1343, being developed by Agouron Pharmaceuticals of La Jolla, California, does have biological activity against HIV in people. Eight patients, given 300 mg of AG1343 three times a day for periods ranging from 3 to 28 days, show
Management of HIV infection during pregnancy: new options, new questions. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Clin Care. 1995 Jun;7(6):45-7, 49. Unique Identifier : AIDSLINE AIDS/96700435; Cotton D; Watts H; ACTG 076 demonstrated that the frequency of perinatal HIV transmission can be reduced by administering AZT to HIV-infected pregnant women and their newborns. The rate of vertical transmission in ACTG 076 was approximately eight percent, or one-third o
Abnormal cryptococcal serology in an asymptomatic patient. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Clin Care. 1995 Jun;7(6):48, 52. Unique Identifier : AIDSLINE AIDS/96700436; Zuger A; The case of an asymptomatic HIV-infected patient with abnormal cryptococcal serology is presented. Cryptococcal infection was detected through a routine serum cryptococcal antigen (titer of 1:256). A second examination revealed no overt clinical symptoms. This raises the question of whether HIV-positive patients shoul
New trial proposed for when drugs fail. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Treat News. 1995 May 19;(no 223):1-4. Unique Identifier : AIDSLINE AIDS/96700445; James JS; On May 11, 1995, community AIDS representatives met with members of the Clinical Trials subcommittee of the Inter-Company Collaboration for AIDS Drug Development (ICC) to discuss several proposals. David Barry, M.D., chairman of the Clinical Trials subcommittee, suggested an innovative trial design that would include
Abbott: major protest over lack of access. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Treat News. 1995 May 19;(no 223):7. Unique Identifier : AIDSLINE AIDS/96700446; Abbott Laboratories refusal to provide any compassionate access to ABT-538, the company s experimental protease inhibitor, has caused U.S. AIDS organizations representatives to call for a protest. The first phase of the protest, scheduled from May 16 through May 22, involves representatives of some of the largest U.S
Religious coalition opposes gene patents. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Treat News. 1995 May 19;(no 223):8. Unique Identifier : AIDSLINE AIDS/96700447; James JS; The biotechnology industry is concerned about a coalition of mainstream religious leaders, working with Jeremy Rifkin of the Foundation of Economic Trends, who oppose the patenting of human and animal life forms, body parts, and genes. The coalition called a press conference on May 18 to ask the government to prohibit
California: new drugs added to AIDS drug assistance program. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Treat News. 1995 May 19;(no 223):8. Unique Identifier : AIDSLINE AIDS/96700448; Eighteen new drugs were added to the California AIDS Drug Assistance Program in March, 1995. These drugs, in addition to the 25 drugs already in the program, can be fully or partially reimbursed for people with HIV with moderate incomes. The new drugs include: alpha interferon, bleomycin sulfate, cyclophosphamide, dex
First women's HIV conference hears go-for-broke antiretroviral strategy. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: J Int Assoc Physicians AIDS Care. 1995 Apr;1(3):6-11. Unique Identifier : AIDSLINE AIDS/96700522; Mascolini M; The antiretroviral strategy discussion at the first HIV Infection in Women Conference in 1995 is summarized. Kathleen E. Squires, MD, stated that retroviral therapy should begin as soon as a person tests positive for HIV, whatever the CD4+ count. Others, however, advise that current agents are too toxic to be given co
Herpesvirus infections. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: J Int Assoc Physicians AIDS Care. 1995 Apr;1(3):12-6. Unique Identifier : AIDSLINE AIDS/96700523; Cockerell CJ; University of Texas, Southwestern Medical Center, Dallas, TX.; Some of the more common herpesviruses, human herpesvirus types 1, 2, and 6; varicella zoster virus; Epstein-Barr virus; and cytomegalovirus , are discussed. Discussions include the incidence, pathogenesis, clinical manifestations, histopathology, and differential diagnosis of these
Update on vaccine development in AIDS and cancer. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: J Int Assoc Physicians AIDS Care. 1995 Apr;1(3):18-24. Unique Identifier : AIDSLINE AIDS/96700524; MacDougall DS; Discussions at the Second International Conference on Engineered Vaccines for Cancer and AIDS on the similarities and differences between molecular biology, and the prevention and treatment of cancer and AIDS are summarized. Specific topics included peptide vaccines, the carcinoembryonic antigen as a potential target
The growing shadow of tuberculosis. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: J Int Assoc Physicians AIDS Care. 1995 Apr;1(3):26-7. Unique Identifier : AIDSLINE AIDS/96700525; Nary G; A new global tuberculosis pandemic has arisen that is expected to become the leading cause of death in people with AIDS by the year 2000. The surge in tuberculosis cases has been linked to co-infection with HIV, new epidemics in Eastern Europe, drug-resistant strains, inadequate treatment regimens, lack of compliance
N.C. college to pay $325,000 to coach fired because of AIDS. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Policy Law. 1995 May 5;10(8):1, 11. Unique Identifier : AIDSLINE AIDS/96700526; To settle a discrimination lawsuit, Campbell University agreed to pay $325,000 to a physical education instructor fired in 1993 after the university learned he had AIDS. Officials from the North Carolina university said the instructor, known as John Doe, posed a direct threat to students and himself. The Equal Employm
Bill would require informing mothers of baby's HIV status. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Policy Law. 1995 May 5;10(8):1, 7. Unique Identifier : AIDSLINE AIDS/96700527; Nearly 200 House of Representatives members, mostly Democrats, have sponsored legislation that would require states to tell parents or other legal guardians if their newborn babies test positive for HIV antibodies. Currently, health departments in 45 states, the District of Columbia,
Blood recipient unable to recover damages based on fraud. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Policy Law. 1995 May 5;10(8):2. Unique Identifier : AIDSLINE AIDS/96700528; A court ruled that Elisabeth Monaco is unable to sue for fraud after acquiring HIV through a blood transfusion in 1982. Monaco, who sued the hospital, her cardiologist, and two physicians, claimed she did not learn she had received
Patient who sat on bloody stretcher can't seek damages. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Policy Law. 1995 May 5;10(8):3-4. Unique Identifier : AIDSLINE AIDS/96700529; The Connecticut Supreme Court has refused to allow hospital patient Allen Barrett to recover damages arising from his fear of contracting HIV from sitting on a blood-soaked stretcher. The court said that medical evidence showed no sign that contact with the blood put the patient at risk of HIV infection during his sta
Two pilots seek reinstatement because they had HIV, not AIDS. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Policy Law. 1995 May 5;10(8):5-6. Unique Identifier : AIDSLINE AIDS/96700530; Two pilots, Capts. Paul H. Rafalowski and R. Christopher Prilliman, have sued United Airlines on charges that they were unlawfully grounded because of their HIV disease. The pilots were ordered on medical retirement after United officials learned they are HIV-positive. The pilots denied claims by the airline that thei
Judge upholds closing of theater that was site of high-risk sex. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Policy Law. 1995 May 5;10(8):4. Unique Identifier : AIDSLINE AIDS/96700531; New York City s decision to close a gay movie theater where inspectors found male patrons engaging in unsafe sexual activity with other men was upheld by Justice Marilyn G. Diamond of the Supreme Court in Manhattan. She rejected the theater owner s argument that the city s March 31, 1995 closure of the New David Cinem
Study theorizes that HIV existed centuries ago in African hamlets. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Policy Law. 1995 May 5;10(8):6. Unique Identifier : AIDSLINE AIDS/96700532; David Mindell, a University of Michigan researcher, is disputing the popular theory about the origin of AIDS--that monkeys spread the virus to humans within the last fifty years. Mindell says his research suggests that HIV may actually be a very old virus that originated in humans, infecting small numbers of people in
Pregnancy laws becoming a hot topic in state legislatures. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Policy Law. 1995 May 5;10(8):8-9. Unique Identifier : AIDSLINE AIDS/96700533; Many states are making legislative attempts to modify public policy regarding perinatal transmission of HIV since reports of a study last year indicate that use of the antiviral drug, AZT , during pregnancy, labor and childbirth, could cut by two-third
Appeals court rejects wife's claim against husband for his infidelity. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Policy Law. 1995 May 5;10(8):10. Unique Identifier : AIDSLINE AIDS/96700534; Appeals Court Justice Robert F. Utter denied a woman s claim that she was entitled to recover damages because she feared her husband s infidelity could have exposed her to HIV infection. Utter said state law does not recognize a legal duty to disclose extramarital sexual relations to one s spouse. The woman, known as
Study finds extremely low risk of HIV infection in football. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Policy Law. 1995 May 5;10(8):12. Unique Identifier : AIDSLINE AIDS/96700535; According to researcher Dr. Lawrence S. Brown Jr., of the Addiction Research and Treatment Corp. in New York, the chance of a professional football player becoming infected with HIV on the field is less than 1 in 85 million. The study provides further evidence to those who say there is no medical or public health reas
Appeals court upholds firing of HIV-positive doctor. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Policy Law. 1995 May 19;10(9):1, 8-11. Unique Identifier : AIDSLINE AIDS/96700537; The Fourth U.S. Circuit Court of Appeals in Richmond, Virginia, upheld a lower court ruling that said a Baltimore hospital acted properly in firing an HIV-positive neurosurgical resident because of the chance he might accidentally infect patients during operations. The resident, John Doe, was stuck with a needle while
N.Y. facility fined $75,000 for isolating patient for nine months. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Policy Law. 1995 May 19;10(9):2. Unique Identifier : AIDSLINE AIDS/96700538; The New York State Division of Human Rights has fined Marcus Garvey Nursing Home and its administrator $75,000 after the home placed a stroke patient with HIV in isolation for more than nine months. Anthony Frazier was placed in confinement after being persuaded to be tested for and found to be positive for HIV antibo
Former employee not protected against cap on health benefits. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Policy Law. 1995 May 19;10(9):3. Unique Identifier : AIDSLINE AIDS/96700539; Ruling on a case in Georgia, U.S. District Judge Owen Forrester said the Americans with Disabilities Act (ADA) does not protect former employees from discriminatory treatment in fringe benefits. Timothy Bourgeois charged that Garner Food Services, which owned and operated a chain of Hardee s Restaurants, fired him in
Dallas halts programs that rely on condoms and candor. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Policy Law. 1995 May 19;10(9):4-5. Unique Identifier : AIDSLINE AIDS/96700540; In March 1995, the Dallas County Health Department s commissioners voted 4-1 to bar the health department from handing out condoms, passing out bleach kits to injection drug users, or disseminating brochures that explain candidly how people contract HIV and how its spread can be prevented. The commissioners said the c
David Duke, running for governor, proposes tattooing people with HIV. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Policy Law. 1995 May 19;10(9):7. Unique Identifier : AIDSLINE AIDS/96700541; Former Ku Klux Klan leader, David Duke, planning a second run for governor of Louisiana, said he would curb the AIDS epidemic by tattooing people who are infected with HIV. His suggestion is to put indelible, glow-in-the-dark tattoos on the genitals of people infected with HIV. According to Duke, it may sound very dra
Recap of Federal court rulings in health-care employment. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Policy Law. 1995 May 19;10(9):9. Unique Identifier : AIDSLINE AIDS/96700542; A recap of major Federal court rulings involving health care workers and HIV in the workplace is provided. The list includes court decisions on surgery, reassignment of duties, transmission risk, and job transfer.
Nurse distraught by needle injury cannot be forced to take HIV test. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Policy Law. 1995 May 19;10(9):11. Unique Identifier : AIDSLINE AIDS/96700543; A New York court has refused to order Lillian Brown, a nurse, to be tested for HIV antibodies in order to proceed with her claim that she suffered emotional anguish after puncturing her thumb with a needle at work. The decision was made since she never claimed that her anguish was based on an HIV infection, rather on
First major museum exhibit on the science of AIDS. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: J Int Assoc Physicians AIDS Care. 1995 May;1(4):6-7. Unique Identifier : AIDSLINE AIDS/96700544; Nary G; The Chicago Museum of Science and Industry recently opened its 4,000-square-foot permanent exhibit on the science of AIDS. The exhibit is designed to educate visitors about immunology and virology by presenting AIDS as an example of an immune system breakdown and showing advances made in research and prevention of dis
An interview with Simon Wain-Hobson, PhD. [interview by Mark Mascolini] Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: J Int Assoc Physicians AIDS Care. 1995 May;1(4):8-13. Unique Identifier : AIDSLINE AIDS/96700545; Wain-Hobson S; Institut Pasteur, Paris, Cedex 15, France.; Simon Wain-Hobson, PhD, of the Pasteur Institute in Paris, addresses: 1) HIV research from his viewpoint; 2) three ways of attacking HIV; 3) information on conflicts between researchers and how to avoid them; 4) why the third world cannot wait for a vaccine; 5) the existence of other deadly viruses directly descending
Can immune system small talk be broadcast as anti-HIV therapy? Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: J Int Assoc Physicians AIDS Care. 1995 May;1(4):14-22. Unique Identifier : AIDSLINE AIDS/96700546; Mascolini M; Speakers at the First International Symposium on HIV and Cytokines, held on March 15-17 in Reims, presented their views on topics in immunology and treatment of HIV infection with respect to cytokines. The first topic addressed the double-edged sword of the immune system which aids the spread of HIV infection as follo
A need for clear animal data--and the animal might have to be man. An interview with Robert L. Coffman, PhD. [interview by Mark Mascolini] Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: J Int Assoc Physicians AIDS Care. 1995 May;1(4):23-4. Unique Identifier : AIDSLINE AIDS/96700547; Coffman RL; DNAX Research Institute, Palo Alto, CA.; Robert L. Coffman, PhD, presents his thoughts on the potential for anti-HIV cytokine strategies. The limiting factor for many trials is the availability of background toxicity data from good animal models. It would not be surprising if cytokine-based therapies are ultimately limited by toxicities found. Coffman furthe
Bacterial infections. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: J Int Assoc Physicians AIDS Care. 1995 May;1(4):26-32. Unique Identifier : AIDSLINE AIDS/96700548; Cockerell CJ; University of Texas, Southwestern Medical Center, Dallas, TX.; Bacterial skin infections normally pose no threat to an immunocompetent patient but may threaten a seropositive one. For this reason, skin biopsies and cultures should be performed in any immunocompromised patients where bacterial infections are present. The epidemiology, pathogenesis, clinical manifestations, diagnos
CDC suspends testing of newborns. Centers for Disease Control and Prevention. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Policy Law. 1995 Jun 2;10(10):1, 9. Unique Identifier : AIDSLINE AIDS/96700559; The Centers for Disease Control and Prevention (CDC) has announced the suspension of their anonymous HIV testing program for newborn infants. The announcement came on the heels of legislation introduced by Gary Ackerman, D-N.Y., requiring states to tell parents or other legal guardians if their newborn babies test pos
HIV infection isn't necessarily an impairment under the ADA. Americans with Disabilities Act. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Policy Law. 1995 Jun 2;10(10):1, 10-1. Unique Identifier : AIDSLINE AIDS/96700560; A U.S. Circuit Court of Appeals says that it will not automatically regard asymptomatic HIV as an impairment under the Americans with Disabilities Act (ADA). In a case involving Joan M. Ennis, an employee of the National Association of Business and Educational Radio Inc. (NABER), the court said judges should determine
Bill seeks discharge of all HIV-positive military personnel. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Policy Law. 1995 Jun 2;10(10):2. Unique Identifier : AIDSLINE AIDS/96700561; Legislation, introduced in Congress and sponsored by Rep. Robert Dornan, R-Calif., would give an honorary discharge within six months to any military service member who tests positive for HIV antibodies. Those discharged would be assured access to veterans health services. The existing military policy bars entry to r
Republicans retain HOPWA for now, but seek cuts in Medicaid. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Policy Law. 1995 Jun 2;10(10):3-4. Unique Identifier : AIDSLINE AIDS/96700562; Budget plans for fiscal year 1996 are currently being negotiated, with several AIDS programs, as well as Medicaid, in the hot seat. There are two Republican versions of the proposed budget aimed at eliminating the Federal deficit by the year 2002. The Senate version calls for full funding of AIDS programs, including t
Judge's fear of AIDS insufficient reason for tougher sentencing. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 2714.: AIDS Policy Law. 1995 Jun 2;10(10):4. Unique Identifier : AIDSLINE AIDS/96700563; An appeals court ruled that Walter L. White, convicted of child molestation, cannot receive a harsher sentence based on the trial judge s ungrounded fear that the defendant could transmit HIV to others. The court found no evidence that the defendant had HIV, knew he had the virus, or had been counseled previously abou